SGLT
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1548 | Dapagliflozin | <1 mg/mL | 82 mg/mL | 17 mg/mL |
| S2760 | Canagliflozin | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| S8022 | Empagliflozin (BI 10773) | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S5901 | Canagliflozin hemihydrate | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S8103 | Sotagliflozin (LX4211) | <1 mg/mL | 84 mg/mL | 17 mg/mL |
| S5413 | Ertugliflozin | 87 mg/mL | 87 mg/mL | 87 mg/mL |
| S5566 | Dapagliflozin propanediol monohydrate | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S8558 | Tofogliflozin(CSG 452) | 4 mg/mL | 84 mg/mL | 84 mg/mL |
| S8637 | Ipragliflozin (ASP1941) | <1 mg/mL | 80 mg/mL | 80 mg/mL |
| S2342 | Phloretin | <1 mg/mL | 54 mg/mL | 54 mg/mL |
| S2343 | Phlorizin | <1 mg/mL | 87 mg/mL | 9 mg/mL |
特异性亚型抑制剂
SGLT产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozin是一种有效的，选择性的hSGLT2抑制剂，EC50为1.1 nM，比作用于hSGLT1选择性高1200倍。Phase 4。 |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
|
|
| S2760 |
CanagliflozinCanagliflozin是一种高效的，选择性SGLT2抑制剂，作用于hSGLT2，无细胞试验中IC50为2.2 nM，比作用于hSGLT1选择性高413倍。 |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
|
|
| S8022 |
Empagliflozin (BI 10773)Empagliflozin (BI 10773)是一种有效的，选择性SGLT-2抑制剂，IC50为3.1 nM，比作用于SGLT-1， 4， 5和6选择性高300倍以上。Phase 3。 |
Effects of empagliflozin on AMPK/ACC phosphorylation
|
|
| S5901New |
Canagliflozin hemihydrateCanagliflozin hemihydrate是canagliflozin的半水化合物形式。Canagliflozin是SGLT2的抑制剂，对hSGLT2的IC50值为2.2 nM，对hSGLT2的选择性是对hSGLT1的413倍。 |
||
| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211)是一种口服的双重SGLT1/SGLT2抑制剂，IC50分别为 36 nM 和 1.8 nM。Phase 3。 |
||
| S5413New |
ErtugliflozinErtugliflozin is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1. |
||
| S5566New |
Dapagliflozin propanediol monohydrateDapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors. |
||
| S8558 |
Tofogliflozin(CSG 452)Tofogliflozin是一种新型的sodium-glucose co-transporter 2(SGLT2)抑制剂，对hSGLT2和hSGLT1的IC50值分别为2.9 nM和8444 nM。 |
||
| S8637 |
Ipragliflozin (ASP1941)Ipragliflozin (ASP1941)是一种高度选择性的sodium-glucose cotransporter 2 (SGLT2)抑制剂，对hSGLT2的IC50值为7.4 nM，对SGLT2的选择性是对SGLT1的选择性的254倍。 |
||
| S2342 |
PhloretinPhloretin 是一种二氢查尔酮，含有多元酚。 |
Specificity of FDG uptake in BJAB, OCI-LY3 and SU-DHL-6 cells. Cells were incubated without inhibitors or with 2 mM 2-DG, 5 μM cytochalasin B or 10 μM phloretin for 24 h or with 50 μM CoCl2 for 30 min and 100 kBq of FDG for 30 min. Cell-bound radioactivity was normalized to protein concentration determined from a parallel sample and expressed as % of untreated control, mean ± standard deviation from fourfold determinations; Asterisks indicates significant decrease or increase (p < 0.05, Student’s t test)
|
|
| S2343 |
PhlorizinPhlorizin 是有毒的2'-葡萄糖苷根皮素，属于二氢查尔酮，是一种黄酮类化合物。 |
The survival of cells treated with PQ in the presence or absence of STF-31 (d), phlorizin (e), or AA (f) was determined as explained
|
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozin是一种有效的，选择性的hSGLT2抑制剂，EC50为1.1 nM，比作用于hSGLT1选择性高1200倍。Phase 4。 |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
|
|
| S2760 |
CanagliflozinCanagliflozin是一种高效的，选择性SGLT2抑制剂，作用于hSGLT2，无细胞试验中IC50为2.2 nM，比作用于hSGLT1选择性高413倍。 |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
|
|
| S8022 |
Empagliflozin (BI 10773)Empagliflozin (BI 10773)是一种有效的，选择性SGLT-2抑制剂，IC50为3.1 nM，比作用于SGLT-1， 4， 5和6选择性高300倍以上。Phase 3。 |
Effects of empagliflozin on AMPK/ACC phosphorylation
|
|
| S5901New |
Canagliflozin hemihydrateCanagliflozin hemihydrate是canagliflozin的半水化合物形式。Canagliflozin是SGLT2的抑制剂，对hSGLT2的IC50值为2.2 nM，对hSGLT2的选择性是对hSGLT1的413倍。 |
||
| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211)是一种口服的双重SGLT1/SGLT2抑制剂，IC50分别为 36 nM 和 1.8 nM。Phase 3。 |
||
| S5413New |
ErtugliflozinErtugliflozin is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1. |
||
| S5566New |
Dapagliflozin propanediol monohydrateDapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors. |
||
| S8558 |
Tofogliflozin(CSG 452)Tofogliflozin是一种新型的sodium-glucose co-transporter 2(SGLT2)抑制剂，对hSGLT2和hSGLT1的IC50值分别为2.9 nM和8444 nM。 |
||
| S8637 |
Ipragliflozin (ASP1941)Ipragliflozin (ASP1941)是一种高度选择性的sodium-glucose cotransporter 2 (SGLT2)抑制剂，对hSGLT2的IC50值为7.4 nM，对SGLT2的选择性是对SGLT1的选择性的254倍。 |
||
| S2342 |
PhloretinPhloretin 是一种二氢查尔酮，含有多元酚。 |
Specificity of FDG uptake in BJAB, OCI-LY3 and SU-DHL-6 cells. Cells were incubated without inhibitors or with 2 mM 2-DG, 5 μM cytochalasin B or 10 μM phloretin for 24 h or with 50 μM CoCl2 for 30 min and 100 kBq of FDG for 30 min. Cell-bound radioactivity was normalized to protein concentration determined from a parallel sample and expressed as % of untreated control, mean ± standard deviation from fourfold determinations; Asterisks indicates significant decrease or increase (p < 0.05, Student’s t test)
|
|
| S2343 |
PhlorizinPhlorizin 是有毒的2'-葡萄糖苷根皮素，属于二氢查尔酮，是一种黄酮类化合物。 |
The survival of cells treated with PQ in the presence or absence of STF-31 (d), phlorizin (e), or AA (f) was determined as explained
|
