|S1186||BIBR 1532||<1 mg/mL||66 mg/mL||3 mg/mL|
|S1319||Costunolide||<1 mg/mL||47 mg/mL||1 mg/mL|
|S2250||(-)-Epigallocatechin Gallate||23 mg/mL||72 mg/mL||83 mg/mL|
|S8118||RHPS 4 methosulfate||<1 mg/mL||91 mg/mL||<1 mg/mL|
|S4981||Cyclogalegenol||<1 mg/mL||98 mg/mL||19 mg/mL|
|S3894||Cycloastragenol||-1 mg/mL||98 mg/mL||-1 mg/mL|
BIBR 1532是一种有效的，选择性的，非竞争性telomerase抑制剂，无细胞试验中IC50为100 nM。在远高于此IC50的浓度范围下，BIBR 1532对DNA和RNA聚合酶，包括HIV逆转录酶没有抑制作用。
(E, F)The cells were not treated or treated with BIBR1532 before wounds were made. Relative ratio of wound closure per field was shown. (G, H) KrasG12D and KrasG12V-induced migration ability of lung cancer cells was inhibited by BIBR1532 in Transwell invasion assay. Numbers of invasive cells in 10 fields were counted. Magnification: ×200. Representative pictures were shown. Values were the mean of 3 determinations ± SEM (one-way ANOVA, *p < 0.05, **p < 0.01).
Costunolide是一种天然倍半萜类化合物，具有多种生物活性；抑制FPTase，IC50为20 μM，也抑制telomerase（端粒酶），IC50为65-90 μM。
(-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。
(a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.
Cycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.