Telomerase
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1186 | BIBR 1532 | <1 mg/mL | 66 mg/mL | 3 mg/mL |
| S1319 | Costunolide | <1 mg/mL | 47 mg/mL | 1 mg/mL |
| S2250 | (-)-Epigallocatechin Gallate | 23 mg/mL | 72 mg/mL | 83 mg/mL |
| S8118 | RHPS 4 methosulfate | <1 mg/mL | 91 mg/mL | <1 mg/mL |
| S4981 | Cyclogalegenol | <1 mg/mL | 98 mg/mL | 19 mg/mL |
| S3894 | Cycloastragenol | -1 mg/mL | 98 mg/mL | -1 mg/mL |
- Telomerase抑制剂（6）
- 新Telomerase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1186 |
BIBR 1532BIBR 1532是一种有效的，选择性的，非竞争性telomerase抑制剂，无细胞试验中IC50为100 nM。在远高于此IC50的浓度范围下，BIBR 1532对DNA和RNA聚合酶，包括HIV逆转录酶没有抑制作用。 |
(E, F)The cells were not treated or treated with BIBR1532 before wounds were made. Relative ratio of wound closure per field was shown. (G, H) KrasG12D and KrasG12V-induced migration ability of lung cancer cells was inhibited by BIBR1532 in Transwell invasion assay. Numbers of invasive cells in 10 fields were counted. Magnification: ×200. Representative pictures were shown. Values were the mean of 3 determinations ± SEM (one-way ANOVA, *p < 0.05, **p < 0.01).
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| S1319 |
CostunolideCostunolide是一种天然倍半萜类化合物，具有多种生物活性；抑制FPTase，IC50为20 μM，也抑制telomerase（端粒酶），IC50为65-90 μM。 |
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| S2250 |
(-)-Epigallocatechin Gallate(-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。 |
-Epigallocatechin-Gallate-S225001Y0120170210.gif)
-Epigallocatechin-Gallate-S225001Y0120170210.gif)
(a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.
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| S8118 |
RHPS 4 methosulfateRHPS4是一种端粒酶的有效抑制剂。 |
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| S4981New |
CyclogalegenolCyclogalegenol是astragaloside A的糖苷配基衍生物，存在于多种紫云英属物种中，可能可激活端粒酶。 |
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| S3894New |
CycloastragenolCycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells. |
