目录号：A2013 别名: MEDI4736 中文名称：德瓦鲁单抗
For research use only.
Not for use in humans.
Durvalumab (anti-PD-L1)是一种IgG1κ单抗，抑制PD-L1与PD-1/CD80 (B7.1)的相互作用。MW=146.3 kDa。
|产品描述||Durvalumab (anti-PD-L1)是一种IgG1κ单抗，抑制PD-L1与PD-1/CD80 (B7.1)的相互作用。MW=146.3 kDa。|
Durvalumab (anti-PD-L1) is a potent antagonist of PD-L1 function, blocking interaction with PD-1 and CD80 to overcome inhibition of primary human T-cell activation. It does not trigger antibody-dependent cellular cytotoxicity (ADCC).
|体内研究||In vivo MEDI4736 significantly inhibits the growth of human tumors in a novel xenograft model containing coimplanted human T cells. In patients with advanced solid tumors, The linear clearance, volume of distribution and concentration at half maximal elimination (KM) of MEDI4736 are 240 mL/day, 3.6 L and 0.4 μg/mL, respectively. The half-life is ~23 days at doses ≥ 3 mg/kg Q2W. Greater than 99% target saturation (soluble and membrane bound) is expected at ≥40 μg/mL of MEDI4736.|
|配制||PBS buffer, pH 7.2|
|储存条件||Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles|
How to store the antibody?
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.