Durvalumab (anti-PD-L1)

目录号:A2013 别名: MEDI4736 中文名称:德瓦鲁单抗

For research use only.
Not for use in humans.

Durvalumab (anti-PD-L1)是一种IgG1κ单抗,抑制PD-L1PD-1/CD80 (B7.1)的相互作用。MW=146.3 kDa。

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客户使用Selleck该产品发表文献6篇:

质量管理及产品安全说明书

PD-1/PD-L1抑制剂选择性比较

生物活性

产品描述 Durvalumab (anti-PD-L1)是一种IgG1κ单抗,抑制PD-L1PD-1/CD80 (B7.1)的相互作用。MW=146.3 kDa。
靶点
PD-L1/CD80 [1]
(HTRF assay)
PD-1/PD-L1 interaction [1]
(HTRF assay)
0.04 nM 0.1 nM
体外研究

Durvalumab (anti-PD-L1) is a potent antagonist of PD-L1 function, blocking interaction with PD-1 and CD80 to overcome inhibition of primary human T-cell activation. It does not trigger antibody-dependent cellular cytotoxicity (ADCC)[2].

体内研究 In vivo MEDI4736 significantly inhibits the growth of human tumors in a novel xenograft model containing coimplanted human T cells[2]. In patients with advanced solid tumors, The linear clearance, volume of distribution and concentration at half maximal elimination (KM) of MEDI4736 are 240 mL/day, 3.6 L and 0.4 μg/mL, respectively. The half-life is ~23 days at doses ≥ 3 mg/kg Q2W. Greater than 99% target saturation (soluble and membrane bound) is expected at ≥40 μg/mL of MEDI4736[3].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:
- 合并

抗体信息

CAS No. 1428935-60-7
配制 PBS buffer, pH 7.2
同型 Human IgG1
来源 CHO cells
储存条件 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

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常见问题及建议解决方法

  • 问题1:

    How to store the antibody?

  • 回答:

    Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID