Pembrolizumab (anti-PD-1)

目录号:A2005 别名: MK-3475, lambrolizumab 适用于人源及非人源化小鼠

For research use only. Not for use in humans.

Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体,同时也是抑制剂,靶向PD-1,具有潜在的免疫检查点抑制活性和抗肿瘤活性;MW:146.286 KD。

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客户使用Selleck该产品发表文献3篇:

质量管理及产品安全说明书

PD-1/PD-L1抑制剂选择性比较

生物活性

产品描述 Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体,同时也是抑制剂,靶向PD-1,具有潜在的免疫检查点抑制活性和抗肿瘤活性;MW:146.286 KD。
靶点
PD-1 [1]
(Cell-free assay)
体内研究 除了黑素瘤和肺癌,pembrolizumab在其他晚期实体肿瘤和恶性血液病中同样也具有疗效。Pembrolizumab具有在可接受范围的副作用,在具有晚期非小细胞肺癌的患者中,具有抗肿瘤活性[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:
- 合并
  • Objective: To examine the effect of high-dose steroid therapy on lymphocyte proliferation/functionality after stimulation with anti-CD3 in the presence of pembrolizumab
    Cells: Human PBMCs
    Concentrations: 5 µg/mL
    Incubation Time: --
    Method: Isolated PBMCs were pre-treated with prednisone (1 nM - 1 mM) before anti-CD3 stimulation. Anti-CD3-stimulated cells were then incubated with pembrolizumab and their proliferative capacity and IL-2 secretion ability were measured by carboxyfluorescein succinimidyl ester (CFSE) staining and ELISA.
    Reference: http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.e14587

    Pembrolizumab can apply to mice, rat, peripheral blood and other related assays (Only for Reference)

动物实验:
- 合并
  • Objective: To evaluate the pharmacokinetics and biodistribution of 89Zr-labeled Pembrolizumab
    Animal Models: Female ICR (CD-1) mice, Hsd: Sprague-Dawley outbred rats, NSG mice(humanized mice), hu-PBL-SCID mice(humanized mice)
    Formulation: --
    Dosages: --
    Administration: i.v.
    Reference: https://www.ncbi.nlm.nih.gov/pubmed/27493273

    Pembrolizumab can apply to mice, rat, peripheral blood and other related assays (Only for Reference)

抗体信息

Formulation PBS buffer, pH 7.2
Isotype Human IgG4
Source CHO cells
Storage Store the undiluted solution at 4 °C in the dark and avoid freezing

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常见问题及建议解决方法

  • 问题1:

    How to store the antibody?

  • 回答:

    Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID