Pembrolizumab (anti-PD-1)

目录号:A2005 别名: MK-3475, lambrolizumab 中文名称:派姆单抗

For research use only.
Not for use in humans.

Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体,同时也是抑制剂,靶向PD-1,具有潜在的免疫检查点抑制活性和抗肿瘤活性;MW:146.286 KD。

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客户使用Selleck该产品发表文献20篇:

质量管理及产品安全说明书

PD-1/PD-L1抑制剂选择性比较

生物活性

产品描述 Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体,同时也是抑制剂,靶向PD-1,具有潜在的免疫检查点抑制活性和抗肿瘤活性;MW:146.286 KD。
靶点
PD-1 [1]
(Cell-free assay)
体内研究 除了黑素瘤和肺癌,pembrolizumab在其他晚期实体肿瘤和恶性血液病中同样也具有疗效。Pembrolizumab具有在可接受范围的副作用,在具有晚期非小细胞肺癌的患者中,具有抗肿瘤活性[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:
- 合并
  • Objective: To examine the effect of high-dose steroid therapy on lymphocyte proliferation/functionality after stimulation with anti-CD3 in the presence of pembrolizumab
    Cells: Human PBMCs
    Concentrations: 5 µg/mL
    Incubation Time: --
    Method: Isolated PBMCs were pre-treated with prednisone (1 nM - 1 mM) before anti-CD3 stimulation. Anti-CD3-stimulated cells were then incubated with pembrolizumab and their proliferative capacity and IL-2 secretion ability were measured by carboxyfluorescein succinimidyl ester (CFSE) staining and ELISA.
    Reference: http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.e14587

    Pembrolizumab can apply to mice, rat, peripheral blood and other related assays (Only for Reference)

动物实验:
- 合并
  • Objective: To evaluate the pharmacokinetics and biodistribution of 89Zr-labeled Pembrolizumab
    Animal Models: Female ICR (CD-1) mice, Hsd: Sprague-Dawley outbred rats, NSG mice(humanized mice), hu-PBL-SCID mice(humanized mice)
    Formulation: --
    Dosages: --
    Administration: i.v.
    Reference: https://www.ncbi.nlm.nih.gov/pubmed/27493273

    Pembrolizumab can apply to mice, rat, peripheral blood and other related assays (Only for Reference)

抗体信息

CAS No. 1374853-91-4
配制 PBS buffer, pH 7.2
同型 Human IgG4
来源 CHO cells
储存条件 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

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常见问题及建议解决方法

  • 问题1:

    How to store the antibody?

  • 回答:

    Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID