Casein Kinase Inhibitor | Casein Kinase Inhibitor Review

所有产品 Casein Kinase抑制剂(5) 新Casein Kinase产品

产品目录	产品描述	文献引用	实验数据
S2248	Silmitasertib (CX-4945) Silmitasertib (CX-4945)是有效的，选择性CK2(casein kinase 2)抑制剂，无细胞试验中IC50为1 nM,对 Flt3, Pim1 和 CDK1作用效果稍弱(细胞试验中没有活性)。Phase 1/2。	Nat Commun, 2015, 6:7227 Nat Commun, 2014, 5:3393 Leukemia, 2014, 28(3):543-53
S5265^New	TBB TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.
S7642	D 4476 D 4476 是一种有效的，选择性的，细胞渗透性 CK1 (casein kinase 1) 抑制剂，无细胞测定中对来自粟酒裂殖酵母的 CK1 和 CK1δ，IC50 分别为 200 nM 和 300 nM 。也是一种 ALK5 抑制剂，IC50 为 500 nM。	Mol Oncol, 2016, 10(5):677-92	Western blot of signaling effects. 48 hrs after transfection cells were serum‐starved for 12 h before stimulation with Wnt5a for 30 min or 120 min (200 ng/ml) in the presence or absence of casein kinase inhibitor D4476 (100 μM).
S8237	IC261 IC261是一种新型的CK1抑制剂，IC261对CK1的IC50为16 μM，对Cdk5的IC50为4.5 mM。
S5516^New	Ellagic Acid hydrate Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.

产品目录	产品描述	文献引用	实验数据
S2248	Silmitasertib (CX-4945) Silmitasertib (CX-4945)是有效的，选择性CK2(casein kinase 2)抑制剂，无细胞试验中IC50为1 nM,对 Flt3, Pim1 和 CDK1作用效果稍弱(细胞试验中没有活性)。Phase 1/2。	Nat Commun, 2015, 6:7227 Nat Commun, 2014, 5:3393 Leukemia, 2014, 28(3):543-53
S5265^New	TBB TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.
S7642	D 4476 D 4476 是一种有效的，选择性的，细胞渗透性 CK1 (casein kinase 1) 抑制剂，无细胞测定中对来自粟酒裂殖酵母的 CK1 和 CK1δ，IC50 分别为 200 nM 和 300 nM 。也是一种 ALK5 抑制剂，IC50 为 500 nM。	Mol Oncol, 2016, 10(5):677-92	Western blot of signaling effects. 48 hrs after transfection cells were serum‐starved for 12 h before stimulation with Wnt5a for 30 min or 120 min (200 ng/ml) in the presence or absence of casein kinase inhibitor D4476 (100 μM).
S8237	IC261 IC261是一种新型的CK1抑制剂，IC261对CK1的IC50为16 μM，对Cdk5的IC50为4.5 mM。
S5516^New	Ellagic Acid hydrate Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.

Casein Kinase