p97
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7285 | NMS-873 | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S7199 | DBeQ | <1 mg/mL | 68 mg/mL | 5 mg/mL |
| S4921 | MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN) | <1 mg/mL | 39 mg/mL | <1 mg/mL |
- p97抑制剂（3）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7285 |
NMS-873NMS-873是特异性p97的变构抑制剂，IC50=30nM，对VCP/p97的选择性相对于对其他AAA ATPase、Hsp90和其他所检测激酶较高。 |
(E) The mDPC level induced by HN2 in the presence of MG132 or NMS-873. MG132 or NMS-873 were added for 3 h after HN2 exposure and then replaced by normal medium until 24 h. |
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| S7199 |
DBeQDBeQ是一种选择性的，有效的，可逆的，ATP竞争性的p97抑制剂，IC50为1.5 μM。 |
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| S4921 |
MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。 |
WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
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