p97

p97产品

目录号	产品描述	文献引用	实验数据
S7285	NMS-873 NMS-873是特异性p97的变构抑制剂，IC50=30nM，对VCP/p97的选择性相对于对其他AAA ATPase、Hsp90和其他所检测激酶较高。	Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x Nature, 2020, 578(7794):296-300 Nature, 2020, 578(7794):296-300	(E) The mDPC level induced by HN2 in the presence of MG132 or NMS-873. MG132 or NMS-873 were added for 3 h after HN2 exposure and then replaced by normal medium until 24 h.
S7199	DBeQ DBeQ (JRF 12)是一种选择性的，有效的，可逆的，ATP竞争性的p97抑制剂，IC50为1.5 μM。	Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x J Virol, 2020, JVI.01570-20 Cell, 2019, 177(3):766-781
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。	J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133 Phytomedicine, 2019, 61:152859 Toxicol Res (Camb), 2016, 5(1):188-196	WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
S8101	CB-5083 CB-5083是一种有效的，选择性的，且口服具有生物活性的p97 AAA ATPase抑制剂，IC50为 11 nM。Phase 1。	Nat Commun, 2021, 12(1):713 J Cell Biol, 2021, 220(8)e202009147 EMBO Rep, 2021, 22(3):e52164	LN229 GBM cell lysates were immunoblotted with antibodies recognizing specific focal adhesion proteins. Note the decreased levels of Cas, paxillin, and FAK tyrosine phosphorylation in cells treated with CB-5083. In addition, CB-5083 treatment leads to decreased levels of total PTP-PEST expression, but Vcp protein expression levels are not impacted.
S4453New	NPD8733 NPD8733 是癌细胞增强的成纤维细胞迁移的抑制剂，可特异性地结合 valosin-containing protein (VCP)/p97，这是与多种细胞活性(AAA+)蛋白家族相关的 ATP 酶的成员。

目录号	产品描述	文献引用	实验数据
S7285	NMS-873 NMS-873是特异性p97的变构抑制剂，IC50=30nM，对VCP/p97的选择性相对于对其他AAA ATPase、Hsp90和其他所检测激酶较高。	Nat Chem Biol,2021, 10.1038/s41589-020-00726-x Nature,2020, 578(7794):296-300 Nature,2020, 578(7794):296-300	(E) The mDPC level induced by HN2 in the presence of MG132 or NMS-873. MG132 or NMS-873 were added for 3 h after HN2 exposure and then replaced by normal medium until 24 h.
S7199	DBeQ DBeQ (JRF 12)是一种选择性的，有效的，可逆的，ATP竞争性的p97抑制剂，IC50为1.5 μM。	Nat Chem Biol,2021, 10.1038/s41589-020-00726-x J Virol,2020, JVI.01570-20 Cell,2019, 177(3):766-781
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。	J Biomol Struct Dyn,2019, 10.1080/07391102.2019.1640133 Phytomedicine,2019, 61:152859 Toxicol Res (Camb),2016, 5(1):188-196	WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
S8101	CB-5083 CB-5083是一种有效的，选择性的，且口服具有生物活性的p97 AAA ATPase抑制剂，IC50为 11 nM。Phase 1。	Nat Commun,2021, 12(1):713 J Cell Biol,2021, 220(8)e202009147 EMBO Rep,2021, 22(3):e52164	LN229 GBM cell lysates were immunoblotted with antibodies recognizing specific focal adhesion proteins. Note the decreased levels of Cas, paxillin, and FAK tyrosine phosphorylation in cells treated with CB-5083. In addition, CB-5083 treatment leads to decreased levels of total PTP-PEST expression, but Vcp protein expression levels are not impacted.
S4453New	NPD8733 NPD8733 是癌细胞增强的成纤维细胞迁移的抑制剂，可特异性地结合 valosin-containing protein (VCP)/p97，这是与多种细胞活性(AAA+)蛋白家族相关的 ATP 酶的成员。