Celecoxib (SC 58635)

For research use only. Not for use in humans.

Pfizer辉瑞授权 目录号:S1261 中文名称:塞来昔布

Celecoxib (SC 58635) Chemical Structure

CAS No. 169590-42-5

Celecoxib (SC 58635) 是一种选择性COX-2抑制剂,在Sf9细胞中IC50为40 nM。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 795.29 现货
RMB 780.67 现货
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客户使用Selleck生产的Celecoxib (SC 58635)发表文献72篇:

产品安全说明书

COX抑制剂选择性比较

生物活性

产品描述 Celecoxib (SC 58635) 是一种选择性COX-2抑制剂,在Sf9细胞中IC50为40 nM。
靶点
COX-2 [1]
(Sf9 cells)
40 nM
体外研究

在体外, Celecoxib有效选择性抑制COX-2,IC50为40 nM, 而作用于COX-1时,IC50为15 μM。[1]Celecoxib 作用于鼻咽癌 (NPC)细胞系,包括 HNE1和CNE1-LMP1,具有抗增殖效果,IC50分别为32.86 μM 和 61.31 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NVHxUY9GTnWwY4Tpc44hSXO|YYm= M3jXUFAvOS1|MDFOwG0> MV[0PEBp M3jiS4lv\HWlZYOgTWNCVS1zIHX4dJJme3Orb36gc44h[m:2aDDwdo91\WmwIHHu[EBuWk6DIHzleoVt MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjVzM{G3Nkc,OjZ3MUOxO|I9N2F-
H460 NVj1ZYs{TnWwY4Tpc44hSXO|YYm= NWPTTG85OC5zLUOwJO69VQ>? NFWx[Wc1QCCq NUjwelgxcW6mdXPld{BKS0GPLUGg[ZhxemW|c3nvckBwdiCkb4ToJJBzd3SnaX6gZY5lKG2UTlGgcIV3\Wx? NXTzW|hLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1NVMyPzJpPkK2OVE{OTd{PD;hQi=>
HKESC-2 M{jo[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[4SnAzOMLizszN NXHGW4pEPDkEoHlCpC=> Mknyd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJGlEPTEEoI\hcJVmeyCxZjDvfIFtcXCuYYTpcuKh NULpPXJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|Q3QTNpPkK2OFc1Pjl|PD;hQi=>
CaES-17 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:yNOKh|ryP NH\OeVk1QMLiaNMg NEXlRVN{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczD0bIUhUUN3MNMgeoFtfWW|IH;mJI95[WyrcHzheIlvyqB? NHy0[|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS3OFY6Oyd-Mk[0O|Q3QTN:L3G+
HKESC-2 MXLBdI9xfG:|aYOgRZN{[Xl? NHyyOlUzOMLizszN NYm0XlBRPDkEoHlCpC=> MlPMdoVlfWOnczDvfIFtcXCuYYTpck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NWnoSms4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|Q3QTNpPkK2OFc1Pjl|PD;hQi=>
CaES-17 NXu4NoFDSXCxcITvd4l{KEG|c3H5 NGnPOmUzOMLizszN NX;NVmRRPDkEoHlCpC=> NGKxU5Fz\WS3Y3XzJI95[WyrcHzheIlvNWmwZIXj[YQh[XCxcITvd4l{ NIPBUWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS3OFY6Oyd-Mk[0O|Q3QTN:L3G+
A549 M4nvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnQUZo2NTF4MDFOwG0> MXK0POKhcMLi NFLZdI9FVVOR NXyxe3RpUUN3ME2xOlMvPCEQvF2= NVvYUFk1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlQ3PDNpPkK2OFY1PjR|PD;hQi=>
HCC827 NU\FWGRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYi1MVE3OCEQvF2= MnvpOFjDqGkEoB?= MXHEUXNQ MknWTWM2OD14OT6yJO69VQ>? M1u4UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NE[0OlQ{Lz5{NkS2OFY1OzxxYU6=
A549 NIfv[I9CeG:ydH;zbZMhSXO|YYm= MUS4NEDDvU1? NGDxcIc1QMLiaNMg Mo\sSG1UVw>? M1TheIlv\HWlZYOgZZBweHSxc3nz NEizWXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2OFY1Oyd-Mk[0OlQ3PDN:L3G+
HCC827 Moj0RZBweHSxc3nzJGF{e2G7 NIrLWZc5OCEEtV2= MVK0POKhcMLi NHLEUZVFVVOR M1myTolv\HWlZYOgZZBweHSxc3nz MkfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkS2OFMoRjJ4NE[0OlQ{RC:jPh?=
SGC-7901/DDP NV\FRXE5TnWwY4Tpc44hSXO|YYm= Mon6NVDDqML3TR?= NFe5fJczPCCq MmC5bY5pcWKrdIOgZ5lkdG:xeInn[Y5ie2VvMjDhcoQhWC2pbInjc5Bzd3SnaX6g[ZhxemW|c3nvci=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{[1N{c,OjZ2MEe2OVM9N2F-
SGC-7901  MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVqyOOKhcMLi MnHNTWM2OD1zMUWuNFgh|ryP Ml3DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEe2OVMoRjJ4NEC3OlU{RC:jPh?=
SGC-7901/DDP MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXntR2VtOjUEoHlCpC=> NH3wSohKSzVyPUO1MlQ2KM7:TR?= NEfHZ3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|Y2Oyd-Mk[0NFc3PTN:L3G+
SGC-7901/DDP M{fNeGFxd3C2b4Ppd{BCe3OjeR?= M4\xWFExyqEEtV2= M3vzSVI1KGh? M3jIWYlv\HWlZYOgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhid3n0bEBkcXOybHH0bY4> NID3W2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|Y2Oyd-Mk[0NFc3PTN:L3G+
SGC-7901/DDP MoL6SpVv[3Srb36gRZN{[Xl? NFjX[IIyOMLiwsXN MnzkNlQhcA>? MoDIbY5pcWKrdIOgeIhmKGW6cILld5Nqd25ib3[gVE1odHmlb4Dyc5RmcW5idHjyc5VocCCkbH;jb4lv\yCHUEKsJIFv\CCrbnHjeIl3[XSrbnegVGtCKGGwZDDDVmVDyqB? NWTQVW9WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NFc3PTNpPkK2OFA4PjV|PD;hQi=>
SGC-7901/DDP M{i3RWZ2dmO2aX;uJGF{e2G7 M1LzblExyqEEtV2= NGfWUWszPCCq M2XyVoNifXOnczDhJI1iemunZDDk[YNz\WG|ZTDpckB1cGVibHX2[Ywhd2ZiQnPsMVIheHKxdHXpci=> MkD1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEe2OVMoRjJ4NEC3OlU{RC:jPh?=
H357 NEPSSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYi3MlUwOTBizszN NYP5WJdHPDhiaB?= MWDEUXNQ M{PObolvcGmkaYTzJINmdGxiZ4Lve5RpyqClb33ibY5m\CC5aYToJHNi[nW2b3PsZZg> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUi3OEc,OjZyMEm4O|Q9N2F-
TAF NWDJXXFZTnWwY4Tpc44hSXO|YYm= MnTsNVDDqML3TR?= NVzvUHcxPyCm MkHsZYZn\WO2czDURWZ{KGGmaHXzbZZmKHC{b4DldpRq\XN? M4HhT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUi3NVI4Lz5{NUm4O|EzPzxxYU6=
TAF NYH2O|VTTnWwY4Tpc44hSXO|YYm= NE[zOooyOMLiwsXN NILPUno{OC1zMkCgcYlv M1ywZZBwd3KueTDh[oZm[3S|IHTBb5QheGixc4Doc5J6dGG2aX;uJINwdnOncYXlcpQhfG9iRVfGJJNq\26jbHnu[y=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl6N{GyO{c,OjV7OEexNlc9N2F-
TAF NHPIWnJHfW6ldHnvckBCe3OjeR?= NHKwOHEyOMLiwsXN M2HOdlQ5KGh? M2[zRYlv[3KnYYPld{BGT0[UIH3SUmEh[W6mIIDyc5RmcW5iZYjwdoV{e2mxbh?= NH2zT2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm4O|EzPyd-MkW5PFcyOjd:L3G+
PANC-1 MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX2yNE83OC9zMECg{txO MmXvNlQwPDhxN{KgbC=> M1;wWolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZTDhcoQh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ NFTnbY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm3N|A3Oid-MkW5O|MxPjJ:L3G+
PANC-1 Ml61SpVv[3Srb36gRZN{[Xl? NYPsR4lYOjBxNkCvNVAxKM7:TR?= M1;QPVI1KGh? MU\heJRmdnWjdIOgZ4VtdCCrbo\hd4lwdiCjbnSgcYloemG2aX;uJIlvKGFiY3;uZ4VvfHKjdHnvck1l\XCnbnTlcpQhdWGwbnXyxsA> NVzTeGdNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5O|MxPjJpPkK1PVc{ODZ{PD;hQi=>
HeLa  NEfWcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLXNlDDqM7:TdMg M2PjUlI1yqCq M2DoS4VvcGGwY3XzJJJi\GmjdHnvck1qdmS3Y3XkJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:w MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5MESyN{c,OjV5N{C0NlM9N2F-
SACC-83 MnTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\pclIxyqEQvF5CpC=> NUPmV44yOjUEoHi= NHS5bXRmdmijbnPld{Bz[WSrYYTpc44ucW6mdXPl[EBqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= M{LYNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{ewOFI{Lz5{NUe3NFQzOzxxYU6=
HeLa  MVzBdI9xfG:|aYOgRZN{[Xl? NHHVUVEzOMLizszNxsA> NF61[oQzPMLiaB?= M{Swd4VvcGGwY3XzJJJi\GmjdHnvck1qdmS3Y3XkJIlvcGmkaYTpc44hd2ZiY3XscEBieG:ydH;zbZM> MlzyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{C0NlMoRjJ3N{ewOFI{RC:jPh?=
SACC-83 NH7oSJZCeG:ydH;zbZMhSXO|YYm= MU[yNOKh|ryPwrC= NXLsdpRlOjUEoHi= Mmnr[Y5p[W6lZYOgdoFlcWG2aX;uMYlv\HWlZXSgbY5pcWKrdHnvckBw\iClZXzsJIFxd3C2b4Ppdy=> NU[0dnZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O|A1OjNpPkK1O|cxPDJ|PD;hQi=>
HeLa  MVvGeY5kfGmxbjDBd5NigQ>? NX;GOm81OjBxNECvPFAh|ryP NEXkTYgzPMLiaB?= M2LKUJVxemWpdXzheJMhWFSHTjDwZZJ1cWGubImgZpkhcW6qaXLpeIlv\yCVcEGsJIFv\CCjY4TpeoF1\XNiUGTFUkBidmRiaX7hZ5RqfmG2ZYOgRWtV M4LxPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{ewOFI{Lz5{NUe3NFQzOzxxYU6=
SACC-83 MknXSpVv[3Srb36gRZN{[Xl? MWqyNE81OC96MDFOwG0> MnvUNlTDqGh? MUf1dJJm\3WuYYTzJHBVTU5icHHyeIlidGy7IHL5JIlvcGmkaYTpcochW3BzLDDhcoQh[WO2aY\heIV{KFCWRV6gZY5lKGmwYXP0bZZifGW|IFHLWC=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5MESyN{c,OjV5N{C0NlM9N2F-
HLCZ01 M4\lUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWqw5qCUPjEEoNM1US=> NXHwXmNkPDhiaB?= NVTWU4U3TE2VTx?= NYnCSYl5cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{NEi5PUc,OjV5MkS4PVk9N2F-
HLCZ01 Ml[2SpVv[3Srb36gRZN{[Xl? MX:0NOKh|ryP MXiyOEBp NUXncmJxTE2VTx?= M1;sNIlv[3KnYYPld{Bi[2O3bYXsZZRqd25ib3[gS|AwTzFvcHjhd4Uh[2WubIOgZ49u[mmwZXSge4l1cCCLRl6t{tE> NWnu[29sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlQ5QTlpPkK1O|I1QDl7PD;hQi=>
HLCZ01 MYLBdI9xfG:|aYOgRZN{[Xl? NEnIPFg1OMLizszN M1\MRlI1KGh? MmX1SG1UVw>? Mm\S[Y5p[W6lZYOgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhiSV\OMe6y MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MkS4PVkoRjJ3N{K0PFk6RC:jPh?=
HLCZ01 NIHQWIFHfW6ldHnvckBCe3OjeR?= MVG0NOKh|ryP MVmyOEBp MXrEUXNQ MnztbY5kemWjc3XzJHRTSUmOIHX4dJJme3Orb36gZ49u[mmwZXSge4l1cCCLboTldoZmem:wLd8x NIiwRoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyOFg6QSd-MkW3NlQ5QTl:L3G+
MGC803 M4nYTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPCNE03OCEQvF2= NH\CfpQ4OiCq Mn\ETWM2OD12Nz6yOgKBkcLz4pEJOk41OyEQvF2= M3LQUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{CxN|c5Lz5{NUewNVM4QDxxYU6=
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MGC803 NUD1RXFOTnWwY4Tpc44hSXO|YYm= NXzIbnhpPDEEoN88US=> M4W4d|gwOTZxMkSgbC=> NEGxR3J2eHKnZ4XsZZR{KEOkbD3iJIV5eHKnc4Ppc44> NV:1fHk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NFE{PzhpPkK1O|AyOzd6PD;hQi=>
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MCF-7  NUPBdGdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYmxM|ExKM7:TR?= M3jUZ|czKGh? MkTiSG1UVw>? MlPE[Y5p[W6lZYOgZ4Ft[2m2cnnvcE1qdmS3Y3XkJINmdGxiZ4Lve5RpKGmwaHnibZRqd25? NELZNZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[2O|UyOCd-MkW2Olc2OTB:L3G+
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SGC-7901 Ml;qRZBweHSxc3nzJGF{e2G7 Mk\yNVAxKM7:TR?= NI\p[2s4OiCq M1jmPYlv\HWlZYOgZZBweHSxc3nz NYPTepZSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2O|Y{QTRpPkK0Olc3Ozl2PD;hQi=>
SGC-7901 M2fFeWZ2dmO2aX;uJGF{e2G7 NX\2PHY6PzVxMUCwM|EzPSEQvF2= NEDjfHozPC92OD:3NkBp M4fXV4lv[3KnYYPld{Bk[XOyYYPlMVgh[W6mID25JI1TVkFiZYjwdoV{e2mxbjDpckBjd3SqIITpcYUh[W6mIHTvd4UhdWGwbnXy NH;vVHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[3OlM6PCd-MkS2O|Y{QTR:L3G+
LMeC  M4rWcmZ2dmO2aX;uJGF{e2G7 NHPHcGEzOC93MDFOwG0> MlLCOFghcA>? M37ub4Rm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDv[kBEV1hvMjDwdo91\Wmw MoPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 NW\QVphjS2WubDDWbYFjcWyrdImgRZN{[Xl? NFSwdYYzOC93MDFOwG0> M{LMN|Q5KGh? MYTpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? M13PO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
LMeC Mn;jR4VtdCCYaXHibYxqfHliQYPzZZk> MnWwNlAwPTBizszN NU\sfGw1PDhiaB?= M2DwTolvcGmkaYTzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ M4HC[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
CMeC-1 NGLoclFHfW6ldHnvckBCe3OjeR?= MUGyNE82OCEQvF2= M3fMS|Q5KGh? M{TMO4lv\HWlZYOgS|EuWyCjcoLld5Q> NVSxWngyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC NGTIR2ZHfW6ldHnvckBCe3OjeR?= NX\IPXZoOjBxNUCg{txO MlroOFghcA>? NGrPVXlqdmS3Y3XzJGcyNVNiYYLy[ZN1 MlPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 NHnESY9HfW6ldHnvckBCe3OjeR?= M4D4VVIxNzVyIN88US=> NETPdGg1QCCq NVTHcHRo\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gZ5lkdGmwIFSxJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NFHibWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
LMeC NVTaRVlsTnWwY4Tpc44hSXO|YYm= NVTIWnhsOjBxNUCg{txO NYPKZYV2PDhiaB?= MUTk[YNz\WG|ZYOgeIhmKGyndnXsd{Bw\iCleXPsbY4hTDFiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NUS3XnNLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
CMeC-1 MX3GeY5kfGmxbjDBd5NigQ>? MljJNlAwPTBizszN M1PnbFQ5KGh? M3y4O4lv\HWlZYOgZ4F{eGG|ZT2zJIFkfGm4YYTpc44> NX3jSFNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC MWLGeY5kfGmxbjDBd5NigQ>? NGPEeWozOC93MDFOwG0> NHrMNZQ1QCCq M1TJc4lv\HWlZYOgZ4F{eGG|ZT2zJIFkfGm4YYTpc44> M3;SWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
OVCAR-3 NVnT[3AyS2WubDDWbYFjcWyrdImgRZN{[Xl? MlPPNVAhyrWP MlzmNUBp NFfYNlhmdmijbnPld{Bx[WOuaYThfIVtNWmwZIXj[YQhd3[jcnnhckBk[W6lZYKgZ4VtdCCmZXH0bOKh MoSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkCyNlcoRjJ2NUKwNlI4RC:jPh?=
OVCAR-3 MlTtRZBweHSxc3nzJGF{e2G7 NGHy[IoyOCEEtV2= M1XYcVEhcA>? M1;BUZBzd22xdHXzJJBi[2yrdHH4[YwucW6mdXPl[EBieG:ydH;zbZPDqA>? M4mz[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
OVCAR-3 M2jV[GZ2dmO2aX;uJGF{e2G7 NGGzV2kyOCEEtV2= NELzWZkyKGh? M1qyV4VvcGGwY3XzJJBi[2yrdHH4[YwucW6mdXPl[EBi[3SrdnH0bY9vKG:oIHPhd5Bie2VvOdMg MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 M{jnNWZ2dmO2aX;uJGF{e2G7 NE\0e2IyOCEEtV2= M3jVUFEhcA>? M1S3bYRwf25vcnXneYxifGW|IF7GMe67SiCjY4TpeoF1cW:wIHnu[JVk\WRiYomgdIFkdGm2YYjlcC=> NUP5Sm1GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlAzOjdpPkK0OVIxOjJ5PD;hQi=>
OVCAR-3 NXTKTGFbTnWwY4Tpc44hSXO|YYm= NHvWe4wyOCEEtV2= MXGxJIg> M1Xu[IlvcGmkaYTzJJBi[2yrdHH4[YwucW6mdXPl[EBCc3RicHjvd5Bpd3K7bHH0bY9v NETpOpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyNFIzPyd-MkS1NlAzOjd:L3G+
CF33 M1fxc2Z2dmO2aX;uJGF{e2G7 MlHhNVAxKM7:TR?= NV7vcVNoOjRiaB?= MkXEbY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDDU3guOiCycn;0[YlvKGW6cILld5Nqd25? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVyM{e4Nkc,OjR3MEO3PFI9N2F-
CF33 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW1NVAuOTByIN88US=> MVSwMVQh\A>? M2PncIlvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NGfGS5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWwN|c5Oid-MkS1NFM4QDJ:L3G+
CF33 MV\GeY5kfGmxbjDBd5NigQ>? NH7SSlAyOC1zMECg{txO M{CwXVQuOjRiaB?= NVe4ZZJM\GWlcnXhd4V{KGOnbHzzJIlvKHSqZTDTJJBp[XOnIHHu[EBqdmO{ZXHz[ZMh[2WubIOgbY4hTzBxR{GgZZJz\XO2 M4jvN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUCzO|gzLz5{NEWwN|c5OjxxYU6=
LNCaP M17wU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKyNk82NzFyIN88US=> MoHlPVYhcA>? MoLMbY5pcWKrdIOgZ4VtdCCpcn;3eIghe2mpbnnmbYNidnSueTDjc41jcW6nZDD3bZRpKGG2b4L2ZZN1[XSrbh?= M2XuVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm2PVc5Lz5{NEK5Olk4QDxxYU6=
LNCaP MoHkRZBweHSxc3nzJGF{e2G7 NXzURYJXOi93L{GwJO69VQ>? MWe5OkBp MXnpcoR2[2W|IHHwc5B1d3OrczDjc41jcW6nZDD3bZRpKGG2b4L2ZZN1[XSrbh?= NUnFdItERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPVY6PzhpPkK0Nlk3QTd6PD;hQi=>
PC-3  NHXIUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWwMVUxKM7:TR?= M4HJd|Q56oDLaB?= NYew[ZB{cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF{N{i4Nkc,OjRzMke4PFI9N2F-
PC-3  MWLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MoDGNE0yODBizszN MV[3NkBp NWrRXpdI\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy NGLaPFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyO|g5Oid-MkSxNlc5QDJ:L3G+
HCA-7 M13HNWZ2dmO2aX;uJIF{e2G7 MX23NkBpenN? M4Czb2lvcGmkaYTpc44hd2ZiSVytNYJmfGFvaX7keYNm\CCSR1WyJJBzd2S3Y4Tpc44hcW5iaIXtZY4hUEODLUegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEWLQTygSWM2OCB;IECuNFAyOTVizszNMi=> MoCzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3MU[yPFIoRjJ{NUG2NlgzRC:jPh?=
CHO MoPaSpVv[3Srb36gZZN{[Xl? NFnvVFBKdiC4aYTyc{BqdmirYnn0c5J6KHCxdHXuZ5kh[WejaX7zeEBpfW2jbjDDU3guOiCrbjDzeIFjdHlidILhcpNn\WO2ZXSgZ4hqdmW|ZTDoZY1{fGW{IH;2ZZJ6KCiFSF:pJINmdGy|LDDJR|UxKD1iMD6wNFIh|ryPLh?= MnKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB3N{[2PFQoRjFyNUe2Olg1RC:jPh?=
CHO MlXqSpVv[3Srb36gZZN{[Xl? MkXRTY5pcWKrdHnvckBw\iCSR1WtNkBxem:mdXP0bY9vKGmwIFPIU{Bk\WyuczDlfJBz\XO|aX7nJIh2dWGwIFPPXE0zNCCLQ{WwJF0hOC5yMEKg{txONg>? NHz1Ong9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEW3OlY5PSd-MUC1O|Y3QDV:L3G+
CHO M17tPWZ2dmO2aX;uJIF{e2G7 NGPONYVKdiC4aYTyc{Bxd3SnbnP5JIFo[Wmwc4SgbJVu[W5iUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMjDpckB1emGwc3\lZ5Rm\CCFSF:gZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w NVfENXE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCxPVc6PzBpPkGwNVk4QTdyPD;hQi=>
CHO M3fW[2Z2dmO2aX;uJIF{e2G7 M4nI[2lvcGmkaYTvdpkhd2ZiaIXtZY4hWHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzMEBKSzVyIE2gNE4xODJizszNMi=> NHjH[WQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[0N|k1Oid-MUK2OFM6PDJ:L3G+
synovial cells M1LPOGZ2dmO2aX;uJIF{e2G7 NVzxO5R[UW6qaXLpeI9zgSCnZn\lZ5Qhd25icILv[JVkfGmxbjDv[kBkgWOub3;4fYdmdmG|ZT2yJEhEV1hvMjmgdJJwe3SjZ3zhcoRqdiCHMjCoVGdGOiliaX6gbJVu[W5iSVyxMYJmfGFic4TpcZVt[XSnZDDzfY5wfmmjbDDj[YxteyxiSVO1NEA:KDBwMEC3PUDPxE1w NFHiTmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEiyNVcyPid-MUC4NlE4OTZ:L3G+
RAW264.7 NVfWcFdjTnWwY4Tpc44h[XO|YYm= M{K0dGlvcGmkaYTpc44hd2ZiQ1;YMVIhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iTGDTMYlv\HWlZXSgVGdGOiCycn;keYN1cW:wIITy[YF1\WRicILpc5IhfG9iTGDTJINp[WyuZX7n[UBjgSCnbor5cYUhcW2vdX7vZZN{[XluIFnDOVAhRSByLkCwPFch|ryPLh?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nk[2Nkc,OjR4NU[2OlI9N2F-
HEK293 MV7GeY5kfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGOub37l[EBUfHmub4Doc5JiKHCrc4TpcIxifGFiYXzwbIEuS0FiZYjwdoV{e2WmIHnuJIh2dWGwIFjFT|I6OyClZXzsd{BjgSC|dH;wdIVlNW[ub4egR28zKGG|c3H5MEBMcSB;IECuNFM1OiEQvF2u MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV{MEW3O{c,OTl3MkC1O|c9N2F-
SF9 NWfxNVRWTnWwY4Tpc44h[XO|YYm= M2HPfmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQdo9{fGGpbHHu[IlvKEdxSDDzfY51cGG|ZTCyJIV5eHKnc4Pl[EBqdiC|Zj25JINmdGy|IHnu[oVkfGWmIIfpeIgh[mGldXzveolzfXNuIFnDOVAhRSByLkCzOkDPxE1w NXfrfGFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS2PVgyQTBpPkG0Olk5OTlyPD;hQi=>
SF9 M1Ltb2Z2dmO2aX;uJIF{e2G7 NHXBc25KdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdoVkd22kaX7hcpQheHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gd4YuQSClZXzsd{Bqdm[nY4Tl[EB4cXSqIHLhZ5Vtd3[rcoXzMEBKSzVyIE2gNE4xOzZizszNMi=> NHf3coU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUCyOlA2OCd-MUWwNlYxPTB:L3G+
CHO NXTsTZFiTnWwY4Tpc44h[XO|YYm= MkTGTY5pcWKrdHnvckBw\iCFT2iyJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjcnHjbIlld26rYzDhZ4llNXO2aX31cIF1\WRiUFfFNkBxem:mdXP0bY9vKGK7IHXufplu\SCrbX31co9ie3OjeTygTWM2OCB;IECuNFM3KM7:TT6= M2LKV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NU[2NlkxLz5zNUW2OlI6ODxxYU6=
insect cells NH\lV3RHfW6ldHnvckBie3OjeR?= M1LL[|EhdWmw M2nWZmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQ1;YNkBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJJV{cW6pIHHyZYNpcWSxbnnjJIFkcWRiYYOgd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiMTDtbY4heHKrb4KgeI8he3Wkc4TyZZRmKGGmZHn0bY9vKG2nYYP1doVlKG[xcjCyOUB{\WO|IHL5JHROWERvYnHz[YQh[2i{b33v[4VvcWNiYYPzZZktKEmFNUCgQUAxNjB2MjFOwG0v NFSyd3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFI4OCd-MkOwNVAzPzB:L3G+
HNSCC 1483 NXLBPJV[TnWwY4Tpc44h[XO|YYm= M1TRT|MxKG2rboO= M4rJW2lvcGmkaYTpc44hd2ZiQ1;YMVIhcW5iaIXtZY4hUE6VQ1OgNVQ5OyClZXzsd{B2e2mwZzDbNVREZSCjcnHjbIlld26rYzDhZ4llKGG|IIP1ZpN1emG2ZTDwdoVqdmO3YnH0[YQh\m:{IEOwJI1qdnNiYnXmc5JmKHO3YoP0doF1\SCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkA{OCCvaX7zMEBKSzVyIE2gNE4xPTRizszNMi=> NF7mSlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK2N|g6PCd-MkKyOlM5QTR:L3G+
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HeLa NX7aRWxYTnWwY4Tpc44h[XO|YYm= MnnPNVAxKHWP NWnjN2lHOjRiaILz NEfQUnlKdmirYnn0bY9vKG:oIH3QS2VUNTFiaX6gbJVu[W5iSHXMZUBk\WyuczD1d4lv\yCSR1iyJIF{KHO3YoP0doF1\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEmOLUHi[ZRiN1SQRnHsdIhiNXO2aX31cIF1\WRiUFfFNkBxem:mdXP0bY9vKGG2IEGwNEB2VSCjZoTldkAzPCCqcoOgZpkhVENvTWOvUXMh[W6jbInzbZM> MojnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOEO3N|koRjJ2MUizO|M6RC:jPh?=
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RAW264.7 NVKzfYVHSW62aXnu[oxidW2jdH;yfUBie3OjeR?= M33hdVIxKHWP MknZNkBpenN? NGe3VI9CdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNiaX7keYNm\CClb4itNkBmgHC{ZYPzbY9vKGG2IEKwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkhVFCVIHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JI1mfGixZB?= NFPBclA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwNFc6QSd-MkmxNFA4QTl:L3G+
RAW264.7 M{K5Z2FvfGmrbn\sZY1u[XSxcomgZZN{[Xl? NHO4c4QzOCC3TR?= MWGyJIhzew>? NIfWRW5CdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNiaX7keYNm\CCrTl;TJIV5eHKnc4Ppc44h[XRiMkCgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBNWFNiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m NYfz[ZJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFA4QTlpPkK5NVAxPzl7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Fibronectin / Vimentin / N-cadherin / E-cadherin ; 

PubMed: 28978083     


(A) Celecoxib treatment reduces the mesenchymal phenotype in SUM149 cells.

COX-2; 

PubMed: 29515134     


L02 cells exposed to PA (200 μM) with different concentrations of celecoxib (Cel, 5-40 μM) for 24 h. Celecoxib decreased protein expression of COX-2 compared with control as indicated by western blot. 

pAKT / AKT / PPARγ / PTEN ; 

PubMed: 24721996     


Immunoblots from N1-S1 cells treated with different dose celecoxib for 48 h. 

28978083 29515134 24721996
Immunofluorescence
PPARγ / PTEN ; 

PubMed: 24721996     


Immunofluorescence analysis in N1-S1 cells treated with 10 μM celecoxib for 48 h.

24721996
Growth inhibition assay
Cell viability; 

PubMed: 28521485     


Celecoxib caused the concentration-dependent inhibition of (A) GBC-SD and (B) NOZ cell growth. 

28521485
体内研究 在体内, Celecoxib 具有有效的口服抗炎活性。Celecoxib 降低卡拉胶水肿检测中的急性炎症,也降低佐剂性关节炎模型中的慢性炎症,ED50分别为7.1 mg/kg和 0.37 mg/kg/day。此外, Celecoxib作用于Hargreaves 痛模型,也具有镇痛活性,ED50为34.5 mg/kg。此外, Celecoxib 按200 mg/kg剂量处理大鼠,不会产生急性GI毒性,每天按600 mg/kg剂量处理大鼠,持续10天以上,不会产生GI毒性。[1]13.5 Gy 局部胸部照射(LTI)142天(范围为 94-155 天)后,Celecoxib 作用于C3Hf/KamLaw 雌性小鼠模型,提高105天的平均寿命 (范围为79-145 天)。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

体外COX酶实验 :

细胞匀浆与COX-1或COX-2杆状病毒温育3天,通过测评PG合成能力,而测定昆虫细胞中COX蛋白表达。搅匀表达COX-1或COX-2的细胞,然后与花生四烯酸 (10 μM)混合。通过监测PG产量,而测定COX活性。在模拟感染的Sf9细胞中检测不出COX活性。Celecoxib与天然1% CHAPS 匀浆(2-10 μg 蛋白)预温育10分钟,然后加入花生四烯酸。温育10分钟后,通过ELISA检测形成的PGE2。
细胞实验:[2]
- 合并
  • Cell lines: HNE1和CNE1-LMP1
  • Concentrations: 0 到75 μM
  • Incubation Time: 48 小时
  • Method: 使用MTT实验测定 Celecoxib 作用于 NPC细胞的抗增殖效果。细胞接种在96孔板上,粘附24小时。使用浓度不断增高的Celecoxib (0 到 75 μM) (溶于 DMSO, 终浓度 ≤0.1%)处理细胞,然后再温育48小时。 温育后,每孔加入 20 μL MTT 染料 (5 mg/mL) ,然后在37oC下温育4小时。移除上清液,晶体溶解在 DMSO 中,然后在490 nm处测定吸光值。使用 Probit回归模型及SPSS 15.0 软件计算IC50值和95%置信区间。每组实验至少重复进行三次。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: 溶于0.9%生理盐水的0.1 mL 1%卡拉胶溶液或溶于50 μL 矿物油的1 mg 乳酸分枝杆菌注射到雄性Sprague−Dawley大鼠右后腿足垫
  • Dosages: ≤200 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 76 mg/mL (199.28 mM)
Water Insoluble
Ethanol '33 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 381.37
化学式

C17H14F3N3O2S

CAS号 169590-42-5
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01344200 Not yet recruiting Drug: Celecoxib|Drug: Placebo Pharmacokinetics of Celecoxib in Children Children''s Hospital of Eastern Ontario January 2022 Phase 2
NCT04526197 Completed Drug: ALXN1840|Drug: Celecoxib Wilson Disease Alexion Pharmaceuticals July 8 2020 Phase 1
NCT04447261 Completed Drug: BI 1356225|Drug: Placebo Obesity Boehringer Ingelheim June 30 2020 Phase 1
NCT03896113 Recruiting Drug: Celecoxib 200mg capsule Endometrium Cancer Cliniques universitaires Saint-Luc- Université Catholique de Louvain November 13 2019 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

  • 回答:

    For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

COX Signaling Pathway Map

COX Inhibitors with Unique Features

相关COX产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID