Fluoxetine (Lilly 110140) HCl

For research use only. Not for use in humans.

目录号:S1333 中文名称:盐酸氟西汀

Fluoxetine (Lilly 110140) HCl Chemical Structure

CAS No. 56296-78-7

Fluoxetine HCl (Lilly110140)是一种抗抑郁剂,选择性抑制5-羟色胺再摄取。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 630.63 现货
RMB 794.43 现货
RMB 1217.77 现货
RMB 2446.52 现货
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客户使用Selleck生产的Fluoxetine (Lilly 110140) HCl发表文献15篇:

客户使用该产品的3个实验数据:

  • The SWIP phenotype in hlh-17(ns204) animals is unaffected by pretreatment with fluoxetine (C). In all panels, n = 30 animals/rep/strain; dark bars = minus inhibitor; and light bars = plus inhibitor. *P< 0.05; **P<0.005; ***P<0.0005.

    G3 (Bethesda), 2014, 4(6):1081-9.. Fluoxetine (Lilly 110140) HCl purchased from Selleck.

  • Representative photomicrographs of PI-positive neural cells in different groups at 24 h after SAH (n = 3/group). Fluorescence colors: DAPI: blue and PI: red. Scale bar = 100 μm.

    J Neuroinflammation, 2017, 14(1):186. Fluoxetine (Lilly 110140) HCl purchased from Selleck.

  • Immunofluorescence test confirmed the activation of microglia with higher level of TNFα expression. Ipt and Flu treatment clearly reversed the all significant changes to normal levels. White arrows indicate TNFα, CD11b and Hoechst co-located.

    Brain Res Bull, 2017, 130:146-155. Fluoxetine (Lilly 110140) HCl purchased from Selleck.

产品安全说明书

5-HT Receptor抑制剂选择性比较

生物活性

产品描述 Fluoxetine HCl (Lilly110140)是一种抗抑郁剂,选择性抑制5-羟色胺再摄取。
靶点
5-HT [1]
体外研究

Fluoxetine阻断细胞增殖的下调,导致海马细胞的不可避免的冲击(IS)。[1] Fluoxetine增加成年大鼠的海马的齿状回的新生细胞的数量。Fluoxetine也增加了前度皮质的增殖细胞的数目。[2] Fluoxetine加速未成熟神经元的成熟。Fluoxetine增强海马齿状回的神经依赖的长时程增强(LTP)。[3] Fluoxetine而不是Citalopram, Fluvoxamine, Paroxetine和Sertraline,增加前额叶皮层中去甲肾上腺素和多巴胺的细胞外水平。在急性全身给药后,Doxazosin产生强劲而持续增加的去甲肾上腺素和多巴胺的胞外浓度。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HEK293 MoT5SpVv[3Srb36gZZN{[Xl? NGLHfHVKdmirYnn0bY9vKG:oIH;mJIh2dWGwIGTSSWsyKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINp[W6wZXygZ5VzemWwdIOsJGlEPTB;MUVOwG0> NUfDeFI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PFgxPDVpPkK2OVg5ODR3PD;hQi=>
tsA201 NGS4WpNHfW6ldHnvckBie3OjeR?= MVrJcohq[mm2aX;uJI9nKG:oIHj1cYFvKFSURVuxJIV5eHKnc4Pl[EBqdiC2c1GyNFEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPoZY5v\WxiY4XydoVvfHNuIFnDOVA:OToQvF2= NHnIRZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW4PFA1PSd-Mk[1PFgxPDV:L3G+
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MG 63 (6-TG R) M3T0VpFJXFNiYYPzZZk> MYnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
RD M17wUGFvfGm4aYLhcEBie3OjeR?= NIPiTIM2KG2rboO= MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDFcpRmem:4aYL1d{BFPjhiVWOvT3kwOTRvMUi5OVMhcW6oZXP0[YQhcW5iaIXtZY4hWkRiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHnuZ5Vj[XSnZDDmc5IhPSCvaX7zJJVv\GW{IIPoZYtqdmdiY3;u[Il1cW:wIHHu[EBu\WG|dYLl[EBi\nSncjCzJIRigXNiYomgcoV2fHKjbDDy[YQh\HmnLXLhd4VlKHCqb4TvcYV1emmlIH3leIgtKEWFNUC9Ne69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODlzMkm0OEc,OzB7MUK5OFQ9N2F-
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Huh7 MmXYRY51cX[rcnHsJIF{e2G7 NFzYb3dCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBFTU6YMjDpcoZm[3SnZDDpckBpfW2jbjDIeYg4KGOnbHzzJIJ6KHGUVD3QR3Ih[W6jbInzbZMtKEmFNUC9NE4{QM7:TR?= NIKxNpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPFQ1Pyd-M{GxNlg1PDd:L3G+

... Click to View More Cell Line Experimental Data

体内研究 在动物成年雄性SD大鼠中,Fluoxetine扭转不可避免的冲击导致的逃避潜伏期。[1] 在动物成年雄性SD大鼠中,Fluoxetine和Olanzapine联用产生稳健,持续的细胞外多巴胺水平([DA](前))和去甲肾上腺素([东北](前))的增加,超过基准达361%和272%,这是显著大于两种药物单独使用。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 69 mg/mL (199.54 mM)
Water 4 mg/mL (11.56 mM)
Ethanol '69 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 345.79
化学式

C17H18F3NO.HCl

CAS号 56296-78-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04676139 Recruiting Drug: Fluoxetine|Drug: Placebo Nocturnal Enuresis Mansoura University July 1 2020 Phase 3
NCT01615055 Withdrawn Drug: Fluoxetine|Other: Placebo Cognitive Dysfunction University of California Los Angeles|City of Hope Medical Center June 2018 Early Phase 1
NCT03390933 Recruiting Drug: Fluoxetine Depression|Hemodialysis-Induced Symptom MetroHealth Medical Center March 1 2018 Phase 4
NCT02767999 Recruiting Drug: Fluoxetine|Drug: Placebo|Radiation: fMRI Stroke University Hospital Toulouse February 27 2017 Phase 4
NCT03476525 Recruiting Drug: Fluoxetine Obesity Morbid Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital November 2 2016 --
NCT02063425 Terminated Drug: Fluoxetine|Drug: Placebo of fluoxetine Cerebral Infarction Centre Hospitalier St Anne February 2014 Not Applicable

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID