5-HT Receptor

信号通路图

研究领域

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S1333 Fluoxetine HCl 4 mg/mL 69 mg/mL 69 mg/mL
s9039 Albiflorin 96 mg/mL
S5655 Venlafaxine <1 mg/mL 55 mg/mL <1 mg/mL
S5239 Paroxetine mesylate -1 mg/mL 85 mg/mL -1 mg/mL
S5485 Desipramine Hydrochloride -1 mg/mL 60 mg/mL -1 mg/mL
S1441 Venlafaxine HCl 55.5 mg/mL 55.5 mg/mL 55.5 mg/mL
S1869 Dapoxetine HCl 68 mg/mL 68 mg/mL 68 mg/mL
S1483 Iloperidone <1 mg/mL 27 mg/mL 4 mg/mL
S8021 Vortioxetine (Lu AA21004) HBr <1 mg/mL 76 mg/mL 17 mg/mL
S1336 Fluvoxamine maleate <1 mg/mL 87 mg/mL 87 mg/mL
S4053 Sertraline HCl <1 mg/mL 69 mg/mL 15 mg/mL
S3024 Lamotrigine <1 mg/mL 10 mg/mL 3 mg/mL
S2541 Clomipramine HCl 70 mg/mL 70 mg/mL 70 mg/mL
S4113 Desvenlafaxine <1 mg/mL 37 mg/mL 3 mg/mL
S4064 Escitalopram Oxalate 25 mg/mL 83 mg/mL <1 mg/mL
S2084 Duloxetine HCl <1 mg/mL 67 mg/mL <1 mg/mL
S3140 Milnacipran HCl 57 mg/mL 57 mg/mL 57 mg/mL
S3183 Amitriptyline HCl 15 mg/mL 63 mg/mL 63 mg/mL
S1642 Methyldopa <1 mg/mL 2 mg/mL <1 mg/mL
S4749 Citalopram HBr 81 mg/mL 81 mg/mL 81 mg/mL
S8183 Pimavanserin 100 mg/mL 100 mg/mL 100 mg/mL
S4112 Desvenlafaxine Succinate <1 mg/mL 80 mg/mL <1 mg/mL
S2582 Trazodone HCl <1 mg/mL 4 mg/mL <1 mg/mL
S3175 Atomoxetine HCl 2 mg/mL 58 mg/mL 37 mg/mL
S2459 Clozapine <1 mg/mL 65 mg/mL 32 mg/mL
S2493 Olanzapine <1 mg/mL 62 mg/mL 9 mg/mL
S2232 Ketanserin <1 mg/mL 2 mg/mL <1 mg/mL
S1245 Latrepirdine 2HCl <1 mg/mL 24 mg/mL 13 mg/mL
S5714 lurasidone <1 mg/mL 7 mg/mL <1 mg/mL
S5326 Dolasetron <1 mg/mL 64 mg/mL <1 mg/mL
S5153 Tetrahydroberberine -1 mg/mL 6 mg/mL -1 mg/mL
S5538 Tropisetron 56 mg/mL 10 mg/mL -1 mg/mL
S5472 Nafronyl oxalate salt 94 mg/mL 94 mg/mL 94 mg/mL
S5428 Promazine hydrochloride -1 mg/mL 64 mg/mL -1 mg/mL
S4889 Perospirone hydrochloride -1 mg/mL 92 mg/mL -1 mg/mL
S5052 Granisetron -1 mg/mL 11 mg/mL -1 mg/mL
S3706 Sarpogrelate hydrochloride 93 mg/mL 93 mg/mL 30 mg/mL
S3723 Ramosetron Hydrochloride 63 mg/mL 63 mg/mL 1 mg/mL
S2698 RS-127445 <1 mg/mL 56 mg/mL 8 mg/mL
S1243 Agomelatine <1 mg/mL 48 mg/mL 48 mg/mL
S1283 Asenapine maleate <1 mg/mL 80 mg/mL <1 mg/mL
S3005 Paroxetine HCl 1 mg/mL 73 mg/mL 35 mg/mL
S1615 Risperidone <1 mg/mL 4 mg/mL 4 mg/mL
S1444 Ziprasidone HCl <1 mg/mL 90 mg/mL <1 mg/mL
S2663 WAY-100635 Maleate <1 mg/mL 85 mg/mL 85 mg/mL
S2112 Blonanserin <1 mg/mL <1 mg/mL <1 mg/mL
S2849 SB269970 HCl <1 mg/mL 11 mg/mL <1 mg/mL
S1345 Granisetron HCl 69 mg/mL 1 mg/mL 1 mg/mL
S2016 Mirtazapine <1 mg/mL 53 mg/mL 53 mg/mL
S2894 SB742457 <1 mg/mL 78 mg/mL 2 mg/mL
S2677 BRL-15572(dihydrochloride) <1 mg/mL 96 mg/mL 40 mg/mL
S8010 PRX-08066 Maleic acid 104 mg/mL 104 mg/mL 98 mg/mL
S1390 Ondansetron HCl 24 mg/mL 66 mg/mL 10 mg/mL
S1898 Tropisetron HCl 46 mg/mL 35 mg/mL <1 mg/mL
S1394 Pizotifen Malate <1 mg/mL 21 mg/mL <1 mg/mL
S2106 Azasetron HCl 3 mg/mL <1 mg/mL <1 mg/mL
S4249 Flopropione <1 mg/mL 36 mg/mL 36 mg/mL
S4086 Loxapine Succinate <1 mg/mL 89 mg/mL 2 mg/mL
S1996 Ondansetron <1 mg/mL 0.1 mg/mL <1 mg/mL
S2856 SB 271046 hydrochloride <1 mg/mL 40 mg/mL <1 mg/mL
S3050 Palonosetron HCl 67 mg/mL <1 mg/mL <1 mg/mL
S2865 VUF 10166 <1 mg/mL 21 mg/mL 61 mg/mL
S4635 Cyproheptadine hydrochloride <1 mg/mL 70 mg/mL 13 mg/mL
S4748 Ondansetron Hydrochloride Dihydrate 73 mg/mL 73 mg/mL 40 mg/mL
S4694 Alosetron Hydrochloride 1 mg/mL <1 mg/mL <1 mg/mL
S2346 Puerarin <1 mg/mL 86 mg/mL <1 mg/mL
S4283 Cyclobenzaprine HCl 62 mg/mL 62 mg/mL 62 mg/mL
S2669 LY310762 HCl <1 mg/mL 0.4 mg/mL <1 mg/mL
S5401 Tegaserod Maleate <1 mg/mL 83 mg/mL 8 mg/mL
S5253 Cisapride <1 mg/mL 93 mg/mL <1 mg/mL
S4839 Mosapride -1 mg/mL 84 mg/mL -1 mg/mL
S1436 Tianeptine sodium 91 mg/mL 91 mg/mL 91 mg/mL
S1432 Sumatriptan Succinate 83 mg/mL 83 mg/mL <1 mg/mL
S2875 Prucalopride <1 mg/mL 60 mg/mL 38 mg/mL
S1975 Aripiprazole <1 mg/mL 90 mg/mL <1 mg/mL
S1488 Naratriptan HCl 22 mg/mL 74 mg/mL <1 mg/mL
S1607 Rizatriptan Benzoate 46 mg/mL 20 mg/mL <1 mg/mL
S1649 Zolmitriptan <1 mg/mL 58 mg/mL 58 mg/mL
S1385 Mosapride Citrate <1 mg/mL 90 mg/mL <1 mg/mL
S3180 Eletriptan HBr <1 mg/mL 93 mg/mL <1 mg/mL
S4247 Prucalopride Succinate 97 mg/mL 97 mg/mL <1 mg/mL
S4259 Vilazodone HCl <1 mg/mL 96 mg/mL <1 mg/mL
S2096 Almotriptan Malate <1 mg/mL 94 mg/mL 53 mg/mL
S2852 BRL-54443 <1 mg/mL 46 mg/mL 2 mg/mL
S8447 8-OH-DPAT (8-Hydroxy-DPAT) <1 mg/mL 49 mg/mL 49 mg/mL
S4256 Buspirone HCl 84 mg/mL 84 mg/mL 36 mg/mL
S4639 Brexpiprazole <1 mg/mL 24 mg/mL <1 mg/mL
S4751 Cisapride hydrate <1 mg/mL 96 mg/mL <1 mg/mL
S2025 Urapidil HCl 85 mg/mL 24 mg/mL 1 mg/mL
S4244 Serotonin HCl 42 mg/mL 42 mg/mL 2 mg/mL
S1333 Fluoxetine HCl 4 mg/mL 69 mg/mL 69 mg/mL
s9039 Albiflorin 96 mg/mL
S5655 Venlafaxine <1 mg/mL 55 mg/mL <1 mg/mL
S5239 Paroxetine mesylate -1 mg/mL 85 mg/mL -1 mg/mL
S5485 Desipramine Hydrochloride -1 mg/mL 60 mg/mL -1 mg/mL
S1441 Venlafaxine HCl 55.5 mg/mL 55.5 mg/mL 55.5 mg/mL
S1869 Dapoxetine HCl 68 mg/mL 68 mg/mL 68 mg/mL
S1483 Iloperidone <1 mg/mL 27 mg/mL 4 mg/mL
S8021 Vortioxetine (Lu AA21004) HBr <1 mg/mL 76 mg/mL 17 mg/mL
S1336 Fluvoxamine maleate <1 mg/mL 87 mg/mL 87 mg/mL
S4053 Sertraline HCl <1 mg/mL 69 mg/mL 15 mg/mL
S3024 Lamotrigine <1 mg/mL 10 mg/mL 3 mg/mL
S2541 Clomipramine HCl 70 mg/mL 70 mg/mL 70 mg/mL
S4113 Desvenlafaxine <1 mg/mL 37 mg/mL 3 mg/mL
S4064 Escitalopram Oxalate 25 mg/mL 83 mg/mL <1 mg/mL
S2084 Duloxetine HCl <1 mg/mL 67 mg/mL <1 mg/mL
S3140 Milnacipran HCl 57 mg/mL 57 mg/mL 57 mg/mL
S3183 Amitriptyline HCl 15 mg/mL 63 mg/mL 63 mg/mL
S1642 Methyldopa <1 mg/mL 2 mg/mL <1 mg/mL
S4749 Citalopram HBr 81 mg/mL 81 mg/mL 81 mg/mL
S8183 Pimavanserin 100 mg/mL 100 mg/mL 100 mg/mL
S4112 Desvenlafaxine Succinate <1 mg/mL 80 mg/mL <1 mg/mL
S2582 Trazodone HCl <1 mg/mL 4 mg/mL <1 mg/mL
S3175 Atomoxetine HCl 2 mg/mL 58 mg/mL 37 mg/mL
S3196 Azacyclonol 2 mg/mL 53 mg/mL 53 mg/mL

特异性亚型抑制剂

产品目录 产品描述 文献引用 实验数据
S1333

Fluoxetine HCl

Fluoxetine HCl是一种抗抑郁剂,选择性抑制5-羟色胺再摄取。

s9039New

Albiflorin

Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.

S5655New

Venlafaxine

Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

S5239New

Paroxetine mesylate

Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.

S5485New

Desipramine Hydrochloride

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.

S5071New

Duloxetine

Duloxetine(LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.

S1441

Venlafaxine HCl

Venlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI),用于治疗重度抑郁症,泛焦虑症,急性焦虑症以及社交恐惧症。

S1869

Dapoxetine HCl

Dapoxetine HCl 是一种短效的,新型选择性5-羟色胺再摄取抑制剂。

S1483

Iloperidone

Iloperidone是一种dopamine (D2)/serotonin (5-HT2) receptor抑制剂,用于治疗精神分裂症。

S8021

Vortioxetine (Lu AA21004) HBr

Vortioxetine (Lu AA21004) HBr是一种5-羟色胺抑制剂,抑制5-HT1A5-HT1B5-HT3A5-HT7受体和SERTIC50分别为15 nM, 33 nM, 3.7 nM, 19 nM和1.6 nM。

S1336

Fluvoxamine maleate

Fluvoxamine maleate是一种选择性5-羟色胺再摄取抑制剂(SSRI)。

S4053

Sertraline HCl

Sertraline HCl是一种5-HT抑制剂, Ki值为13 nM.

S3024

Lamotrigine

Lamotrigine是一种新型抗惊厥药剂,作用于人类血小板和大鼠脑突触体,抑制5-羟色胺(5-HT)吸收,IC50分别为240 μM和474 μM。

S2541

Clomipramine HCl

Clomipramine HCl 是Clomipramine的盐酸盐,抑制5-羟色胺转运蛋白(SERT),去甲肾上腺素转运体(NET)和多巴胺转运蛋白(DAT),Ki分别为0.14, 54和3 nM。

S4113

Desvenlafaxine

Desvenlafaxine是一种5-羟色胺(5-HT)去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。

S4064

Escitalopram Oxalate

Escitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI),Ki值为0.89 nM.

S2084

Duloxetine HCl

Duloxetine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂,Ki为4.6 nM,用于治疗重度抑郁症和广泛性焦虑症(GAD)。

S3140

Milnacipran HCl

Milnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT),其IC50分别是77 nM和420 Nm

S3183

Amitriptyline HCl

Amitriptyline HCl 是一种三环抗抑郁药,抑制5-羟色胺受体,去甲肾上腺素受体, 5-HT4, 5-HT2和sigma 1受体, IC50分别为3.45 nM, 13.3 nM, 7.31 nM, 235 nM和287 nM。

S1642

Methyldopa

Methyldopa 是DOPA 脱羧酶竞争性抑制剂,ED50为21.8 mg/kg。

S4749

Citalopram HBr

Citalopram HBr是一种抗抑郁剂,是一种常用于口服途径的选择性serotonin reuptake抑制剂,IC50为1.8 nM。

S8183

Pimavanserin

Pimavanserin是一种高效选择性的5-HT2A反向激动剂,其pIC50 为8.73,用于治疗帕金森病相关的精神错乱。

S4112

Desvenlafaxine Succinate

Desvenlafaxine Succinate是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM

S2582

Trazodone HCl

Trazodone HCl 是一种抗抑郁药,属于5-羟色胺受体拮抗剂和再摄取抑制剂,用于治疗焦虑症。

S3175

Atomoxetine HCl

Atomoxetine HCl是一种选择性的去甲肾上腺素(NE)转运体抑制剂,Ki为5 nM,作用于人体5-HT和DA转运体亲和力比其低15和290倍。

S2459

Clozapine

Clozapine 是一种有效的5-HT1C受体拮抗剂,作用于5-HT刺激的磷酸肌醇水解,IC50为110 nM。

S2493

Olanzapine

Olanzapine是一种高亲和力的5-HT2 5-羟色胺和多巴胺D2受体拮抗剂。

S2232

Ketanserin

Ketanserin 是一种特异性的5-HT2A 5-羟色胺受体拮抗剂,作用于大鼠和人5-HT2A,Ki为2.5 nM。

S1245

Latrepirdine 2HCl

Latrepirdine具有口服活性及神经活性,可以作为包括histamine receptors, GluR, 和5-HT receptors在内的多个药物靶点的拮抗剂,用作抗组织胺的药物。

S5714New

lurasidone

Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.

S5326New

Dolasetron

Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. It has minimal activity at other known serotonin receptors, and has low affinity for dopamine receptors.

S5153New

Tetrahydroberberine

Tetrahydroberberine is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.

S5538New

Tropisetron

Tropisetron is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

S5472New

Nafronyl oxalate salt

S5428New

Promazine hydrochloride

Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.

S4889New

Perospirone hydrochloride

Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.

S5052New

Granisetron

Granisetron是serotonin receptor (5HT-3 selective)的拮抗剂,在癌症化疗过程中,被用作止吐剂和止恶心药。

S3706New

Sarpogrelate hydrochloride

Sarpogrelate是一种选择性的5-HT2A拮抗剂,对5-HT2A, 5-HT2C和5-HT2B受体的pKi值分别为8.52、7.43和6.57。

S3723New

Ramosetron Hydrochloride

Ramosetron Hydrochloride是ramosetron的盐酸盐形式,ramosetron是选择性的serotonin (5-HT) receptor拮抗剂,具有潜在的止吐作用。

S2698

RS-127445

RS-127445是一种选择性5-HT2B受体拮抗剂,pKi为9.5,pIC50为10.4,比作用于其他5-HT受体选择性高1000倍以上。

S1243

Agomelatine

Agomelatine对5-HT2C受体具有拮抗作用,因而是一种去甲肾上腺素-多巴胺抑制解除剂(NDDI)。

S1283

Asenapine maleate

Asenapine maleate是一种高亲和性的包括 serotonin, norepinephrine, dopaminehistamine receptors在内的多种受体的拮抗剂,用于治疗神经分裂症以及抑郁狂躁型忧郁症。

S3005

Paroxetine HCl

Paroxetine是SSRI类抗抑郁药。

S1615

Risperidone

Risperidone 是一种多靶点的拮抗剂,作用于dopamine, serotonin, adrenergic and histamine receptors,用于治疗精神分裂症以及抑郁狂躁型忧郁症。

S1444

Ziprasidone HCl

Ziprasidone HCl 是一类有效的dopamineserotonin (5-HT) receptor的拮抗剂,用于精神分裂症以及双向性障碍的治疗。

S2663

WAY-100635 Maleate

WAY-100635 Maleate是一种有效的,选择性的5-HT1A受体拮抗剂,IC50为0.95 nM。

S2112

Blonanserin

Blonanserin 是一种新型的非典型抗精神病药物,是有效的多巴胺D2(Ki为14.8 nM)和5-羟色胺5-HT2(Ki为3.98 nM)受体拮抗剂。

S2849

SB269970 HCl

SB269970 HCl是SB-269970的盐酸盐形式,是一种5-HT7受体拮抗剂,pKi为8.3,比作用于其他受体选择性高50倍以上。

S1345

Granisetron HCl

Granisetron HCl是一种5-HT3受体拮抗剂。

S2016

Mirtazapine

Mirtazapine 是一种adrenergicseroton receptor拮抗剂,用于治疗抑郁症。

S2894

SB742457

SB742457是一种高选择性5-HT6受体拮抗剂,pKi为9.63,比作用于其他受体选择性高100倍以上。Phase 2。

S2677

BRL-15572(dihydrochloride)

BRL-15572是一种5-HT1D受体拮抗剂,pKi为7.9,对5-HT1A和5-HT2B受体具有强的亲和力,比作用于5-HT1B受体选择性高60倍。

S8010

PRX-08066 Maleic acid

PRX-08066 Maleic acid是一种选择性的5-HT2B受体拮抗剂,IC50为3.4 nM,作用于MCT大鼠模型,防止肺动脉高压的严重性。Phase 2。

S1390

Ondansetron HCl

Ondansetron HCl是5-羟色胺5-HT3受体拮抗剂。

S1898

Tropisetron HCl

Tropisetron HCl是一种选择性5-HT3受体拮抗剂和α7-烟碱受体激动剂,作用于5-HT3受体,IC50为70.1±0.9 nM。

S1394

Pizotifen Malate

Pizotifen Malate用于治疗经常性偏头痛。

S2106

Azasetron HCl

Azasetron HCl是一种选择性5-HT3受体拮抗剂,IC50为0.33 nM,用于癌症化疗引起的恶心和呕吐。

S4249

Flopropione

Flopropione是一种解痉药或止痉挛剂,作为5-HT1A受体拮抗剂。

S4086

Loxapine Succinate

Loxapine Succinate是D2DR和D4DR抑制剂,5-羟色胺受体拮抗剂,也是Dibenzoxazepine类的抗精神病试剂。

S1996

Ondansetron

Ondansetron是一种5-羟色胺5-HT3受体拮抗剂,主要用于止吐。

S2856

SB 271046 hydrochloride

SB271046是一种口服生物有效的,选择性的5-HT6受体拮抗剂,pKi为8.9,比作用于其他5-HT受体亚型选择性高200倍。

S3050

Palonosetron HCl

Palonosetron HCl是一种5-HT3受体拮抗剂,用于预防和治疗化疗引起的恶心呕吐。

S2865

VUF 10166

VUF 10166是一种新型有效的,竞争性5-HT3A受体拮抗剂,Ki为0.04 nM,对5-HT3AB受体的亲和力显著下降。

S4635

Cyproheptadine hydrochloride

Cyproheptadine hydrochloride是非选择性的5HT2拮抗剂,其IC50为0.6 nM。它同时还是一个SETD7/9的抑制剂。

S4748

Ondansetron Hydrochloride Dihydrate

Ondansetron是一种高度特异的、选择性血清素5-HT3 receptor拮抗剂(Ki=6.16 nM),对多巴胺受体具有较低的亲和力。

S4694

Alosetron Hydrochloride

Alosetron Hydrochloride是alosetron的盐酸盐形式,alosetron是一种有效的、选择性的5-HT3受体拮抗剂。

S2346

Puerarin

Puerarin 是一种5-HT2C受体和苯二氮位点拮抗剂。

S4283

Cyclobenzaprine HCl

Cyclobenzaprine HCl 是一种通过抑制痛觉发挥作用的肌肉松弛剂, 用于治疗肌肉痉挛。是5-HT2 receptor拮抗剂。

S2669

LY310762 HCl

LY310762是一种5-HT1D受体拮抗剂,Ki为249 nM,对5-HT1B受体具有较低的亲和力。

S5401New

Tegaserod Maleate

Tegaserod Maleate is a hydrogen maleate salt form of tegaserod, which is a 5-HT4 receptor partial agonist and binds with high affinity to 5-HT4 receptors. It has limited affinity for 5-HT1 receptors and no appreciable affinity for other 5-HT receptors, muscarinic, adrenergic, dopaminergic or opiate receptors.

S5253New

Cisapride

Cisapride is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.

S4839New

Mosapride

Mosapride是胃动力药,是选择性的5HT4激动剂。

S1436

Tianeptine sodium

Tianeptine sodium是一种选择性5-羟色胺再摄取增强剂(SSRE),用于治疗重度抑郁发作。

S1432

Sumatriptan Succinate

Sumatriptan Succinate是一种含有磺酰胺基团的曲坦类磺胺类药物,用于治疗偏头痛。

S2875

Prucalopride

Prucalopride是一种选择性,高亲和力的5-HT受体激动剂,作用于5-HT4A5-HT4B受体,Ki分别为2.5 nM和8 nM,比作用于5-HT受体亚型选择性高290倍以上。

S1975

Aripiprazole

Aripiprazole is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.

S1488

Naratriptan HCl

Naratriptan 是一种曲坦类治疗偏头痛的药物。

S1607

Rizatriptan Benzoate

Rizatriptan Benzoate 是5-HT1激动剂,是一种曲坦类治疗偏头痛的药物。

S1649

Zolmitriptan

Zolmitriptan 是一种选择性5-羟色胺受体激动剂。

S1385

Mosapride Citrate

Mosapride Citrate是一种促胃肠动力药,是选择性5HT4激动剂。

S3180

Eletriptan HBr

Eletriptan HBr 是一种选择性的5-羟色胺1B和1D受体激动剂,Ki值分别为0.92 nM和3.14 nM。

S4247

Prucalopride Succinate

Prucalopride是一种选择性的,高亲和力5-HT4受体激动剂,作用于与慢性便秘相关的受损的肠胃运动,从而使排便正常。

S4259

Vilazodone HCl

Vilazodone是一个组合的五羟色胺再摄取特定抑制剂(SSRI)和5-HT1A受体的部分激动剂,目前正在临床评估抑郁症的治疗。

S2096

Almotriptan Malate

Almotriptan Malate是一种选择性5-羟色胺1B/1D(5-HT1B/1D)受体激动剂,用于治疗成人偏头痛发作。

S2852

BRL-54443

BRL-54443是一种5-HT1E5-HT1F受体激动剂,pKi分别为8.7和9.25,对5-HT1A, 5-HT1B, 5-HT1D受体具有弱的结合亲和力。

S8447

8-OH-DPAT (8-Hydroxy-DPAT)

8-OH-DPAT (8-Hydroxy-DPAT)是一种经典的5-HT1A激动剂,pIC50为8.19。对5-HT1结合位点亚型具有近1000倍选择性,其半衰期为1.5小时。

S4256

Buspirone HCl

Buspirone是一种血清素类(5HT(1A)受体激动剂)抗焦虑药,有D(2)多巴胺能作用。

S4639

Brexpiprazole

Brexpiprazole是一种新型的多巴胺受体D25-羟色胺1A受体的部分激动剂,同时也是5-羟色胺2A受体去甲肾上腺素alpha1B、alpha2C受体的拮抗剂。其对D2L, 5-HT1A, 5-HT2A, α1B受体和 α2C受体的Ki值分别为 0.3, 0.12, 0.47, 0.17 和 0.59 nM。

S4751

Cisapride hydrate

Cisapride是直接的、选择性5-HT4 receptor激动剂,IC50为0.483 μM。也是间接的拟副交感神经药。

S2025

Urapidil HCl

Urapidil HCl是Urapidil的盐酸盐形式,是α1-肾上腺素能受体拮抗剂和5-HT1A受体激动剂,pIC50分别为6.13和6.4。

S4244

Serotonin HCl

Serotonin HCl是一种单胺类神经递质和内源性5-HT受体激动剂。

S1333

Fluoxetine HCl

Fluoxetine HCl是一种抗抑郁剂,选择性抑制5-羟色胺再摄取。

s9039New

Albiflorin

Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.

S5655New

Venlafaxine

Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

S5239New

Paroxetine mesylate

Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.

S5485New

Desipramine Hydrochloride

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.

S5071New

Duloxetine

Duloxetine(LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.

S1441

Venlafaxine HCl

Venlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI),用于治疗重度抑郁症,泛焦虑症,急性焦虑症以及社交恐惧症。

S1869

Dapoxetine HCl

Dapoxetine HCl 是一种短效的,新型选择性5-羟色胺再摄取抑制剂。

S1483

Iloperidone

Iloperidone是一种dopamine (D2)/serotonin (5-HT2) receptor抑制剂,用于治疗精神分裂症。

S8021

Vortioxetine (Lu AA21004) HBr

Vortioxetine (Lu AA21004) HBr是一种5-羟色胺抑制剂,抑制5-HT1A5-HT1B5-HT3A5-HT7受体和SERTIC50分别为15 nM, 33 nM, 3.7 nM, 19 nM和1.6 nM。

S1336

Fluvoxamine maleate

Fluvoxamine maleate是一种选择性5-羟色胺再摄取抑制剂(SSRI)。

S4053

Sertraline HCl

Sertraline HCl是一种5-HT抑制剂, Ki值为13 nM.

S3024

Lamotrigine

Lamotrigine是一种新型抗惊厥药剂,作用于人类血小板和大鼠脑突触体,抑制5-羟色胺(5-HT)吸收,IC50分别为240 μM和474 μM。

S2541

Clomipramine HCl

Clomipramine HCl 是Clomipramine的盐酸盐,抑制5-羟色胺转运蛋白(SERT),去甲肾上腺素转运体(NET)和多巴胺转运蛋白(DAT),Ki分别为0.14, 54和3 nM。

S4113

Desvenlafaxine

Desvenlafaxine是一种5-羟色胺(5-HT)去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。

S4064

Escitalopram Oxalate

Escitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI),Ki值为0.89 nM.

S2084

Duloxetine HCl

Duloxetine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂,Ki为4.6 nM,用于治疗重度抑郁症和广泛性焦虑症(GAD)。

S3140

Milnacipran HCl

Milnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT),其IC50分别是77 nM和420 Nm

S3183

Amitriptyline HCl

Amitriptyline HCl 是一种三环抗抑郁药,抑制5-羟色胺受体,去甲肾上腺素受体, 5-HT4, 5-HT2和sigma 1受体, IC50分别为3.45 nM, 13.3 nM, 7.31 nM, 235 nM和287 nM。

S1642

Methyldopa

Methyldopa 是DOPA 脱羧酶竞争性抑制剂,ED50为21.8 mg/kg。

S4749

Citalopram HBr

Citalopram HBr是一种抗抑郁剂,是一种常用于口服途径的选择性serotonin reuptake抑制剂,IC50为1.8 nM。

S8183

Pimavanserin

Pimavanserin是一种高效选择性的5-HT2A反向激动剂,其pIC50 为8.73,用于治疗帕金森病相关的精神错乱。

S4112

Desvenlafaxine Succinate

Desvenlafaxine Succinate是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM

S2582

Trazodone HCl

Trazodone HCl 是一种抗抑郁药,属于5-羟色胺受体拮抗剂和再摄取抑制剂,用于治疗焦虑症。

S3175

Atomoxetine HCl

Atomoxetine HCl是一种选择性的去甲肾上腺素(NE)转运体抑制剂,Ki为5 nM,作用于人体5-HT和DA转运体亲和力比其低15和290倍。

S3196

Azacyclonol

Azacyclonol,也称为γ-pipradol,是一种用于减少精神病患者幻觉的药物。

Tags: 5-HT receptor drugs | Serotonin receptor drugs | 5-HT receptor agonist and antagonist drugs | Serotonin receptor antagonist drugs | Serotonin receptor agonist drugs | 5-HT3 receptor antagonist drugs | 5-HT receptor agonist and antagonist clinical trial | 5-HT receptor agonist and antagonist ic50 | 5-HT receptor agonist and antagonist review