Paclitaxel (NSC 125973)

For research use only. Not for use in humans.

目录号:S1150 别名: PTX, Taxol, Onxal, Abraxane 中文名称:紫杉醇

Paclitaxel (NSC 125973) Chemical Structure

CAS No. 33069-62-4

Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane)是一种microtubule聚合物稳定剂,在人内皮细胞中IC50为0.1 pM。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 749.07 现货
RMB 571.49 现货
RMB 2235.46 现货
RMB 3849.3 现货
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客户使用Selleck生产的Paclitaxel (NSC 125973)发表文献320篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane)是一种microtubule聚合物稳定剂,在人内皮细胞中IC50为0.1 pM。
特性 Paclitaxel 是有丝分裂抑制剂。
靶点
Microtubule (human endothelial cells) [1]
0.1 pM
体外研究

Paclitaxel在104到 105倍更高浓度时,抑制非内皮性人类细胞,IC50 为1 nM -10 nM。Paclitaxel选择性抑制细胞增殖,具有种属特异性,在Paclitaxel极低浓度时,小鼠内皮细胞对 Paclitaxel不敏感。 极低浓度Paclitaxel抑制 人类内皮细胞,但是不影响细胞微管结构,且处理的细胞在 G2/M 期没有出现细胞周期停滞和凋亡,说明这是一种新型尚未查明的作用机制。在体外血管生成实验中,在三维纤维蛋白基质中,极低浓度Paclitaxel阻断人类内皮细胞形成芽管。[1] 在SMF存在时, Paclitaxel 作用于 K562 细胞的有效浓度从50 ng/ml降低到 10 ng/ml。在有或无SMF时,Paclitaxel 使K562 细胞周期停滞与DNA损伤相关。[2] Paclitaxel单独处理四种细胞系,包括A549 细胞,H358, H1395 细胞和H1666 细胞,抑制CDK1,这种作用存在时间依赖性。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
TE-15 NIr1ZVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnMemJKSzVyIE2gNE4xODB{OE[5JO69VQ>? M3ToW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
LC-2-ad M1rw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnqTWM2OCB;IECuNFAxOzF4NzFOwG0> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
RL95-2 M{fvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XjWWlEPTBiPTCwMlAxODZ4OEGg{txO NWHLbotZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
MZ1-PC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP2bGtKSzVyIE2gNE4xODB5Mkm0JO69VQ>? M3fTUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
TE-8 M2\PUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1yxS2lEPTBiPTCwMlAxOTF5NDFOwG0> NH;0SVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
SW954 NHHCXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTVe5pKSzVyIE2gNE4xODFzOEeg{txO M2PSRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
TE-11 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxKD1iMD6wNFEzOzFizszN NIPkUm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
PSN1 NGHnPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxKD1iMD6wNFE{ODFizszN M1jvZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
MOLT-4 NGnDTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknTTWM2OCB;IECuNFAyPDl|IN88US=> NEXpbpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
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NTERA-S-cl-D1 NV\qXnUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjDcYxKSzVyIE2gNE4xODJyOEig{txO MlPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
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RKO MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\PS2lEPTBiPTCwMlAxOjl5NzFOwG0> MoftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
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BB30-HNC Mn7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxKD1iMD6wNFMyOzhizszN MnTrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
ACN NWC1WmFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHqTWM2OCB;IECuNFA{OTV5IN88US=> MlK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
TE-9 MkTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSzW2Q4UUN3MDC9JFAvODB|MkW1JO69VQ>? MlLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
SIG-M5 M4\lNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjH[ox[UUN3MDC9JFAvODB|MkeyJO69VQ>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
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SK-LMS-1 NH:5dXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO2VWN5UUN3MDC9JFAvODB2MEC2JO69VQ>? NVjhSIpmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
GT3TKB M{jke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6xTWM2OCB;IECuNFA1OzN7IN88US=> NHLSVpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
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COLO205 M3:4ZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIq3ZpJIUTVyIE2gNE4xODF5NjFOwG0> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
SF539 MoO5R5l1d3SxeHnjbZR6KGG|c3H5 MYXHTVUxKD1iMD6wNFM3PiEQvF2= M2fHSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd7MEi5OVAoRjd7MEi5OVA9N2F-
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DMS114 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NVvBcop1T0l3MDC9JFAvODF{MzFOwG0> NFTJOXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
OVCAR-3 MkDrR5l1d3SxeHnjbZR6KGG|c3H5 M1nwOmdKPTBiPTCwMlAyQTdizszN NX;hZW1yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
NCI-H460 NFrlTW9EgXSxdH;4bYNqfHliYYPzZZk> MYLHTVUxKD1iMD6wNlE6KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
HOP62 NYr4VZNtS3m2b4TvfIlkcXS7IHHzd4F6 NUDKOW5XT0l3MDC9JFAvODZ5MTFOwG0> NXrXZW1xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
mammary carcinoma Mn\YR5l1d3SxeHnjbZR6KGG|c3H5 NHnjUnBKSzVyIE2gNE4zQTlizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85OTh{Nkm4K|45OTh{Nkm4QE9iRg>?
NCI60 MmPwR5l1d3SxeHnjbZR6KGG|c3H5 NVX6TlVqT0l3MDC9JFAvODByNkWg{txO NYG3XnBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUS2NVY2Oyd-OUS2NVY2OzxxYU6=
MCF-7 NGnQOGlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoHiS2k2OCB;IECuNFAyOSEQvF2= M1HjdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{O1PVcoRjl6N{O1PVc9N2F-
murine leukemic P388 NFW2W4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXrHTVUxKD1iMD6wNVYh|ryP M3vKPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{O1PVcoRjl6N{O1PVc9N2F-
KB NX;ZT4hvS3m2b4TvfIlkcXS7IHHzd4F6 NHzGOHlKSzVyIE2gNE4xODZizszN M2PzUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOUe4NlAxLz5zMEm3PFIxODxxYU6=
MCF7 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXq0XZN5PzJiaB?= MYXJR|UxKD1iMD6wNFIh|ryP NFr1cms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOyOVIzPid-MUGzNlUzOjZ:L3G+
MCF-7 MnW5R5l1d3SxeHnjbZR6KGG|c3H5 MXXFSFUxKD1iMD6wNFQh|ryP M37qV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY4Lz5zMUOzOFU3PzxxYU6=
uterine sarcoma (MES-SA) MknpR5l1d3SxeHnjbZR6KGG|c3H5 MkjlTWM2OCB;IECuNFAxODRizszN NWi1XYpoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3NlgyQTFpPkGxO|I5OTlzPD;hQi=>
nonsmall cell lung carcinoma (NCI-H460) NFjLdFdEgXSxdH;4bYNqfHliYYPzZZk> NYK1UVR2UUN3MDC9JFAvODByMUSg{txO NF\nV5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUeyPFE6OSd-MUG3NlgyQTF:L3G+
colon adenocarcinoma (HT-29) M{TjSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVrBUXN7UUN3MDC9JFAvODByMU[g{txO Mne4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF5MkixPVEoRjFzN{K4NVkyRC:jPh?=
prostate carcinoma (DU-145) MlnUR5l1d3SxeHnjbZR6KGG|c3H5 M{XtfmlEPTBiPTCwMlAxPDh7IN88US=> NWLjTYdTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3NlgyQTFpPkGxO|I5OTlzPD;hQi=>
SW626 NUL0UYZGS3m2b4TvfIlkcXS7IHHzd4F6 MmrWO|IhcA>? M1ntbWlEPTBiPTCwMlAxODBzIN88US=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
Lu1 MlrqR5l1d3SxeHnjbZR6KGG|c3H5 MYm3NkBp NXr3WmVSUUN3MDC9JFAvODFizszN NHu3TYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
MCF7 MormR5l1d3SxeHnjbZR6KGG|c3H5 Ml7aO|IhcA>? MYHJR|UxKD1iMD6wNkDPxE1? M3m5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
P388 Mlr1R5l1d3SxeHnjbZR6KGG|c3H5 NVPu[WgzPzJiaB?= NEjEOnJKSzVyIE2gNE4xOiEQvF2= NFLVblg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
LNCAP M361NGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHT6WZg4OiCq NFzQeJpKSzVyIE2gNE4xOiEQvF2= NWLu[oduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
KB NHfqcYVEgXSxdH;4bYNqfHliYYPzZZk> M2TDdVczKGh? NHnOc4NKSzVyIE2gNE4xOiEQvF2= NELQ[209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
Col2 NFzSc2NEgXSxdH;4bYNqfHliYYPzZZk> NF\adnI4OiCq M4frRmlEPTBiPTCwMlAzKM7:TR?= NX;lOnltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
BC1 NGLUd2FEgXSxdH;4bYNqfHliYYPzZZk> MkD0O|IhcA>? MVPJR|UxKD1iMD6wNkDPxE1? NXvJbZJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
SK-MEL-2 NHLWRYdEgXSxdH;4bYNqfHliYYPzZZk> MoDwO|IhcA>? NX3LS5AyUUN3MDC9JFAvODdizszN MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
L2987 MknTR5l1d3SxeHnjbZR6KGG|c3H5 M3\DW2lEPTBiPTCwMlIh|ryP NWfsfpJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0OFM4QDNpPkGyOFQ{Pzh|PD;hQi=>
colon adenocarcinoma RKO MV;DfZRwfG:6aXPpeJkh[XO|YYm= MXfJR|UxKD1iMD6wNUDPxE1? NFfhdII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMki1Nlc3QCd-MUK4OVI4Pjh:L3G+
NCI-H460 NWLMdlRsS3m2b4TvfIlkcXS7IHHzd4F6 MYi0PEBp M{fpcmlEPTBiPTCwMlAxQTVizszN Mn3EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR4OUW3PVgoRjF2Nkm1O|k5RC:jPh?=
MCF7 MoXOR5l1d3SxeHnjbZR6KGG|c3H5 M3Pz[VQ5KGh? NGK4[HJKSzVyIE2gNE4xOTF{IN88US=> NIryWok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[5OVc6QCd-MUS2PVU4QTh:L3G+
SF268 NYq5SIhVS3m2b4TvfIlkcXS7IHHzd4F6 MmT4OFghcA>? MYrJR|UxKD1iMD6wNlE4KM7:TR?= MnjYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR4OUW3PVgoRjF2Nkm1O|k5RC:jPh?=
MDA-MB-231 NGOxc2ZEgXSxdH;4bYNqfHliYYPzZZk> MoPxOFghcA>? NIHvbIpKSzVyIE2gNE4xODR3IN88US=> NETrT3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm4O|A2OSd-MUS5PFcxPTF:L3G+
MCF7 NEO1em5EgXSxdH;4bYNqfHliYYPzZZk> MX60PEBp NXXhVWh5UUN3MDC9JFAvODB2OTFOwG0> MkT0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVEoRjF2OUi3NFUyRC:jPh?=
A2780 M4D0[GN6fG:2b4jpZ4l1gSCjc4PhfS=> M2HYRlQ5KGh? MX7JR|UxKD1iMD6wNlUh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1NUc,OTR7OEewOVE9N2F-
PC3 NFf6eGFEgXSxdH;4bYNqfHliYYPzZZk> NIPmS4k1QCCq NFXVOYhKSzVyIE2gNE4xPzdizszN MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1NUc,OTR7OEewOVE9N2F-
MCF7 NHHW[FVEgXSxdH;4bYNqfHliYYPzZZk> NYLuNnU3PzJiaB?= MVrJR|UxKD1iMD6wNFE1KM7:TR?= NUXxcFBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTZpPkG0PVg4ODV4PD;hQi=>
multidrug-resistant MCF7 NEH3d4tEgXSxdH;4bYNqfHliYYPzZZk> MWO3NkBp NYn5U4JsUUN3MDC9JFAvOzV2IN88US=> Mom3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVYoRjF2OUi3NFU3RC:jPh?=
PC3 NXi0WnV5S3m2b4TvfIlkcXS7IHHzd4F6 NV3OOopCPDhiaB?= M{[2RmlEPTBiPTCwMlAyPiEQvF2= NEjkVFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxOid-MUWwOFM1ODJ:L3G+
Hep3B MUfDfZRwfG:6aXPpeJkh[XO|YYm= NULPW4ZJPDhiaB?= M1;TN2lEPTBiPTCwMlA{OSEQvF2= M{LmTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFAzLz5zNUC0N|QxOjxxYU6=
NCI-H460 MVzDfZRwfG:6aXPpeJkh[XO|YYm= MV:0PEBp M3LkTGlEPTBiPTCwMlAxQTVizszN MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwOEc,OTVyNEO0NFQ9N2F-
MCF7 M4DrWWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWq0PEBp MVHJR|UxKD1iMD6wNVEzKM7:TR?= NGnLUYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPCd-MUWwOFM1ODR:L3G+
SF268 M1riS2N6fG:2b4jpZ4l1gSCjc4PhfS=> M{HEdVQ5KGh? MYrJR|UxKD1iMD6wNlE4KM7:TR?= MljiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFQoRjF3MESzOFA1RC:jPh?=
KB NXzMXJFIS3m2b4TvfIlkcXS7IHHzd4F6 MnX5SWQ2OCB;IECuNFAxPCEQvF2= NF\VWmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
Lu1 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NYDXcYJnTUR3MDC9JFAvODB{IN88US=> NG\Bd5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
LNCAP NFHZ[XBEgXSxdH;4bYNqfHliYYPzZZk> M3jicmVFPTBiPTCwMlAxPSEQvF2= M{LRZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
RPE1 NYPHVoVkS3m2b4TvfIlkcXS7IHHzd4F6 MWLFSFUxKD1iMD6wNlMh|ryP MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
Col2 NXTEPWd6S3m2b4TvfIlkcXS7IHHzd4F6 MoLVSWQ2OCB;IECuNFQ3KM7:TR?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
T47D MnrvRZBweHSxc3nzJIF{e2G7 MYCyOEBp MX7FR|UxKD1iMD6wN{DPxE1? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkOwNEc,OTV3Nk[zNFA9N2F-
DLD1 NWfT[3M6SXCxcITvd4l{KGG|c3H5 NVfQWHVMOjRiaB?= M3m5XGVEPTBiPTCwMlA4PSEQvF2= NIrpZlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUW2OlMxOCd-MUW1OlY{ODB:L3G+
H1299 M17IbGFxd3C2b4Ppd{Bie3OjeR?= MV:yOEBp MV7FR|UxKD1iMD6xOlMh|ryP NInDN3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUW2OlMxOCd-MUW1OlY{ODB:L3G+
VA13 NH63PFNEgXSxdH;4bYNqfHliYYPzZZk> NInWblQ1QCCq MVjJR|UxKD1iMD6wNFUh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd|MEK0N{c,OTV5M{CyOFM9N2F-
WI 38 NFnVdWxEgXSxdH;4bYNqfHliYYPzZZk> NHrCUFQ1QCCq M1n0SWlEPTBiPTCwMlA1KM7:TR?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd|MEK0N{c,OTV5M{CyOFM9N2F-
Hep G2 NUnwO|hFS3m2b4TvfIlkcXS7IHHzd4F6 M37Yb|Q5KGh? MmrHTWM2OCB;IEiuNUDPxE1? Mk\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5M{CyOFMoRjF3N{OwNlQ{RC:jPh?=
A549 MVfDfZRwfG:6aXPpeJkh[XO|YYm= M{XJS|Q5KGh? M1rhVGlEPTBiPTCxMlI2KM7:TR?= M4j3U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{i3OFYxLz5zNUe4O|Q3ODxxYU6=
SKOV3 NYH5T|l7S3m2b4TvfIlkcXS7IHHzd4F6 MWi0PEBp MXXJR|UxKD1iMT6zOUDPxE1? Mlf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5OEe0OlAoRjF3N{i3OFYxRC:jPh?=
KB MnrrR5l1d3SxeHnjbZR6KGG|c3H5 M1;adFMh\GG7cx?= M2jqOWlEPTBiPTCwMlAxOSEQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjB|OEW0OUc,OTZyM{i1OFU9N2F-
1A9 MkHBR5l1d3SxeHnjbZR6KGG|c3H5 MnrqN{Bl[Xm| NYjBRZRzUUN3MDC9JFAvODB{IN88US=> NHmyN4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkCzPFU1PSd-MU[wN|g2PDV:L3G+
HCT8 NEfNfmVEgXSxdH;4bYNqfHliYYPzZZk> NIi3cWk{KGSjeYO= NHzJcVlKSzVyIE2gNE4xOTNizszN NH7hTI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkCzPFU1PSd-MU[wN|g2PDV:L3G+
A431 MYLD[YxtKGO7Y3zlJIFzemW|dDDhd5NigQ>? MUfFR|UxKD1iMD6wNFkh|ryP NYr0U|hKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zO|cyQDdpPkG2N|c4OTh5PD;hQi=>
VA13 NEC4OplIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEDwbmg1QCCq NWraRXBJUUN3MDC9JFAvODB2MzFOwG0> M3:zVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEm5N|IzLz5zNkS5PVMzOjxxYU6=
WI38 M2POfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3vHT|Q5KGh? M4SxcWlEPTBiPTCwMlA{PCEQvF2= MmniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2OUmzNlIoRjF4NEm5N|IzRC:jPh?=
HepG2 MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFnzSFY1QCCq NHfKfmJKSzVyIE2gOk46KM7:TR?= NYnlTIo5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PVk{OjJpPkG2OFk6OzJ{PD;hQi=>
Aro M1zXSmN6fG:2b4jpZ4l1gSCjc4PhfS=> MoXwTWM2OCB;IECuNFAxOiEQvF2= NEf2VFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
PT45 M3HqPGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4fHTWlEPTBiPTCwMlAxPSEQvF2= NUfwWlc5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
A549 NXzNOIV7S3m2b4TvfIlkcXS7IHHzd4F6 NX[wUmtUUUN3MDC9JFAvODB4IN88US=> NUnNVmxCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
MCF7 Ml7YR5l1d3SxeHnjbZR6KGG|c3H5 NX3GUZc5UUN3MDC9JFAvODB5IN88US=> NFyycGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
HeLa MonuR5l1d3SxeHnjbZR6KGG|c3H5 NVX4PJlQUUN3MDC9JFAvODB6IN88US=> NIDrXI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
Ovcar3 NGrLNFFEgXSxdH;4bYNqfHliYYPzZZk> Mn7TTWM2OCB;IECuNFEh|ryP M2fKPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
HT29 NHHSNWFEgXSxdH;4bYNqfHliYYPzZZk> NEPJN4xKSzVyIE2gNE4xPSEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
H295R NFLic3dEgXSxdH;4bYNqfHliYYPzZZk> MkD2TWM2OCB;IECuNFgh|ryP NF;LRpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
BNL M2TzbmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1j4SWlEPTBiPTCwMlIh|ryP MnztQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
4T1 Mk\nR5l1d3SxeHnjbZR6KGG|c3H5 M4jaRWlEPTBiPTCwMlIh|ryP MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
HepG2 MlPaR5l1d3SxeHnjbZR6KGG|c3H5 M1[3e2lEPTBiPTCwMlMh|ryP MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
U937 GTB MVTDfZRwfG:6aXPpeJkh[XO|YYm= M1W1fFczKGh? M4\ZWGlEPTBiPTCwMlAxPTlizszN NWThXFJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1OlI5PDBpPkG2OVYzQDRyPD;hQi=>
RPMI 8226/s NF64W21EgXSxdH;4bYNqfHliYYPzZZk> MoXnO|IhcA>? NUn6ZWluUUN3MDC9JFAvODB5IN88US=> NGnIZ2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkW2Nlg1OCd-MU[1OlI5PDB:L3G+
CEM/s NImxUY9EgXSxdH;4bYNqfHliYYPzZZk> MkjuO|IhcA>? M{fwOWlEPTBiPTCwMlAxPyEQvF2= M1;ITFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NU[yPFQxLz5zNkW2Nlg1ODxxYU6=
VA13 M13OXGN6fG:2b4jpZ4l1gSCjc4PhfS=> MoPyTWM2OCB;IECuNFA2QSEQvF2= M2[yb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{K0PFQzLz5zNkeyOFg1OjxxYU6=
WI38 Ml3JR5l1d3SxeHnjbZR6KGG|c3H5 NI\aUFdKSzVyIE2gNE4xPDZ6IN88US=> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd{NEi0Nkc,OTZ5MkS4OFI9N2F-
HepG2 NYq1[lJmS3m2b4TvfIlkcXS7IHHzd4F6 NGHFepdKSzVyIE2gPU41QSEQvF2= M3T0SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{K0PFQzLz5zNkeyOFg1OjxxYU6=
HT29 MnO3R5l1d3SxeHnjbZR6KGG|c3H5 NYDsOXNUTUN3MDC9JFAvODB4IN88US=> NVu3OI42RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[4O|A1OjhpPkG2PFcxPDJ6PD;hQi=>
K562 NV\RPJRnS3m2b4TvfIlkcXS7IHHzd4F6 M{P4cGVEPTBiPTCwMlAyPCEQvF2= NVLWTItFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[4O|A1OjhpPkG2PFcxPDJ6PD;hQi=>
MCF7 MlrSR5l1d3SxeHnjbZR6KGG|c3H5 M2P0T2VEPTBiPTCwMlA{PiEQvF2= M4jFblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OEewOFI5Lz5zNki3NFQzQDxxYU6=
VA-13 MlT2R5l1d3SxeHnjbZR6KGG|c3H5 MY\JR|UxKD1iMD6wNFUh|ryP MknpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7M{O4OlgoRjF4OUOzPFY5RC:jPh?=
WI38 MofzR5l1d3SxeHnjbZR6KGG|c3H5 Mn\LTWM2OCB;IECuNFQh|ryP M3;SSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUOzPFY5Lz5zNkmzN|g3QDxxYU6=
VA13 NVjVT4s5S3m2b4TvfIlkcXS7IHHzd4F6 MljjTWM2OCB;IECuNFA2KM7:TR?= Mk\uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
WI38 MkjxR5l1d3SxeHnjbZR6KGG|c3H5 NYTUcWwyUUN3MDC9JFAvODRizszN MmSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
Hep G2 MmDGR5l1d3SxeHnjbZR6KGG|c3H5 MoTyTWM2OCB;IEiuNUDPxE1? NIXnNZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C2O|E2PSd-MUewOlcyPTV:L3G+
TW01 M2ryTGN6fG:2b4jpZ4l1gSCjc4PhfS=> NW\pd4Z{UUN3MDC9JFAvODByMzFOwG0> NXqxZVJFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
MCF7 MYLDfZRwfG:6aXPpeJkh[XO|YYm= MWDJR|UxKD1iMD6wNFA2KM7:TR?= NVzPdm5sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
MKN45 M3nJNmN6fG:2b4jpZ4l1gSCjc4PhfS=> NX\YSFA{UUN3MDC9JFAvODByNTFOwG0> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
MES-SA NYD5UI9jS3m2b4TvfIlkcXS7IHHzd4F6 NV;IR5I2UUN3MDC9JFAvODByNTFOwG0> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
HCT116 MYrDfZRwfG:6aXPpeJkh[XO|YYm= NWWyO|k2UUN3MDC9JFAvODByNjFOwG0> NH6wRpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
RPTEC NHzneYlEgXSxdH;4bYNqfHliYYPzZZk> M3m2eWlEPTBiPTCwMlAxODlizszN NGfSVGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
Hep3B Mlz3R5l1d3SxeHnjbZR6KGG|c3H5 MknTTWM2OCB;IECuNFA2PCEQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
NCI-H226 NUTodFF6S3m2b4TvfIlkcXS7IHHzd4F6 NHfEVmFKSzVyIE2gNE4xODZ6IN88US=> MlLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzMUOyPFgoRjF5MUGzNlg5RC:jPh?=
A498 M2\WNmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVTtXYZVUUN3MDC9JFAvODZzIN88US=> NHfOVVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
MDA435/LCC6 NFfqfppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Ml\YTWM2OCB;IECuNFAzQSEQvF2= NVXSeHdVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVQ2ODVpPkG3NVU1PTB3PD;hQi=>
multidrug resistant MDA435/LCC6 M{XqRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NUG3NGM2UUN3MDC9JFAvODB2ODFOwG0> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
P388 MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Ml:1TWM2OCB;IECuNFIzKM7:TR?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
adriamycin resistant P388 NXfh[4xGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mlr4TWM2OCB;IECuNFMh|ryP NXj5cZFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVQ2ODVpPkG3NVU1PTB3PD;hQi=>
LT12 MnGzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NF7XTms1QCCq MkDmTWM2OCB;IECuNFA3KM7:TR?= NHzoO5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
SKOV3 NF7XfmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NGrV[4E1QCCq NWDueYpxUUN3MDC9JFAvODFizszN MnLHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
NCI-H460 NXXZTYhESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWjveJZyPDhiaB?= Mn\CTWM2OCB;IECuNFEh|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
SF268 M4TXeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NELYdIU1QCCq NHP5e2ZKSzVyIE2gNE4xOSEQvF2= NVXJR2hQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
RKO NGK5SW9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MnvsOFghcA>? NF\DOpdKSzVyIE2gNE4xOSEQvF2= M2LzPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
KB/HeLa MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlPUOFghcA>? MWPJR|UxKD1iMD6wNUDPxE1? M1nZSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
P388 NFPMWGJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NYO1[WozPDhiaB?= NIHCTI5KSzVyIE2gNE4xPCEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
L1210 NVnJN5l5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MlvrOFghcA>? MXfJR|UxKD1iMD6wOkDPxE1? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
LT12 MDR M4nTXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MW[0PEBp MkHxTWM2OCB;IECuOEDPxE1? M2PJclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
A2780 NGW1e2FEgXSxdH;4bYNqfHliYYPzZZk> MnS3TWM2OCB;IECuNFAyKM7:TR?= NVi4cWtnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNFYyOzlpPkG3NlA3OTN7PD;hQi=>
A2780-1A9 NUPWeW9WS3m2b4TvfIlkcXS7IHHzd4F6 NH62TohKSzVyIE2gNE4xODFzIN88US=> Ml;nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
A549 NIXJdHREgXSxdH;4bYNqfHliYYPzZZk> NH\h[4RKSzVyIE2gNE4xODN4IN88US=> M{fzelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
1A9PTX22 NVT3WY9qS3m2b4TvfIlkcXS7IHHzd4F6 MUXJR|UxKD1iMD6wNVkh|ryP M170TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
1A9PTX10 M{fzdWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mlq5TWM2OCB;IECuNFMh|ryP NUWxWJBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNFYyOzlpPkG3NlA3OTN7PD;hQi=>
A2780AD M1exW2N6fG:2b4jpZ4l1gSCjc4PhfS=> NU\kd3N5UUN3MDC9JFAvQSEQvF2= MojDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
KB MnXnRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NF\KTnhKSzVyIE2gNE4xODJ2NTFOwG0> M3TZNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkK4PFc{Lz5zN{KyPFg4OzxxYU6=
COLO205 MYrDfZRwfG:6aXPpeJkh[XO|YYm= MWXJR|UxKD1iMD6wNFM{KM7:TR?= NFnKXng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KyPFg4Oyd-MUeyNlg5PzN:L3G+
KB8.5 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MnvITWM2OCB;IECuNFI3KM7:TR?= NXnGR2lpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNlg5PzNpPkG3NlI5QDd|PD;hQi=>
KBV1 MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MV7JR|UxKD1iMj6wNVMh|ryP M4TXcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkK4PFc{Lz5zN{KyPFg4OzxxYU6=
A2780 NUL6T|FpS3m2b4TvfIlkcXS7IHHzd4F6 MWXJR|UxKD1iMD6wNFA4KM7:TR?= M1TGbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkO5OVk4Lz5zN{KzPVU6PzxxYU6=
2780AD M3LOZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnrvTWM2OCB;IECuOVM2KM7:TR?= MmTjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVcoRjF5MkO5OVk4RC:jPh?=
1A9 MWPDfZRwfG:6aXPpeJkh[XO|YYm= NWPHOoF[TUR3MDC9JFAvODBzIN88US=> M3Xsc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
MCF7 NH;mfYVEgXSxdH;4bYNqfHliYYPzZZk> MXXFSFUxKD1iMD6wNFEyKM7:TR?= Ml60QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
DU145 M1y5e2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1\DNGVFPTBiPTCwMlAxOTNizszN MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
KB NVrCcVNjS3m2b4TvfIlkcXS7IHHzd4F6 M1fmOWVFPTBiPTCwMlAxOThizszN MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
A549 NEDOV3REgXSxdH;4bYNqfHliYYPzZZk> NHv3N3hGTDVyIE2gNE4xODJ|IN88US=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
LNCAP MmLpR5l1d3SxeHnjbZR6KGG|c3H5 NFu3VotGTDVyIE2gNE4xODJ4IN88US=> M2fCXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
PC3 NX3wZnR5S3m2b4TvfIlkcXS7IHHzd4F6 MojkSWQ2OCB;IECuNFU2PSEQvF2= NIjXO5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O1NFg{PCd-MUezOVA5OzR:L3G+
KBVIN MoPmR5l1d3SxeHnjbZR6KGG|c3H5 NXrmeHhJTUR3MDC9JFAvOzFzIN88US=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
A2780 NEG2SYJEgXSxdH;4bYNqfHliYYPzZZk> MXLJR|UxKD1iMD6wNFE3KM7:TR?= M4rkVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{m1OFY2Lz5zN{O5OVQ3PTxxYU6=
A2780/AD M1;rUmN6fG:2b4jpZ4l1gSCjc4PhfS=> MnntTWM2OCB;IECuPVIh|ryP NFzGWlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O5OVQ3PSd-MUezPVU1PjV:L3G+
KB NG\sV2JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NFzLZXZKSzVyIE2gNE4xODJ2NTFOwG0> MkLVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MU[1NlQoRjF5NEG2OVI1RC:jPh?=
COLO205 NIT4TXJEgXSxdH;4bYNqfHliYYPzZZk> NXj0N3NiUUN3MDC9JFAvODB|MzFOwG0> M4i3[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVI1Lz5zN{SxOlUzPDxxYU6=
KB8.5 M3rQU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXzJR|UxKD1iMD6wNlYh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
KBV1 NX;DVVhRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MYXJR|UxKD1iMj6wNVMh|ryP NFq0NIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxOlUzPCd-MUe0NVY2OjR:L3G+
neural precursor MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXG1OZlUTUN3MDC9JFAvODFizszN M3viVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
OVCAR-3 M1LsVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVy2[ol1UUN3MDC9JFAvODByMjFOwG0> NWPJR29mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
MDA-MB-231 MmDER5l1d3SxeHnjbZR6KGG|c3H5 MXLJR|UxKD1iMD6wNFQ2KM7:TR?= NET2UG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxPVA3PSd-MUe0NVkxPjV:L3G+
MCF7 MoD2R5l1d3SxeHnjbZR6KGG|c3H5 MkjmTWM2OCB;IECuNFA1QSEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOUC2OUc,OTd2MUmwOlU9N2F-
NCI-H1299 MW\DfZRwfG:6aXPpeJkh[XO|YYm= NF\xN5E6PiCq MkjQTWM2OCB;IECuNFE2KM7:TR?= M4jGfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG5NFY2Lz5zN{SxPVA3PTxxYU6=
A2780 MnWxR5l1d3SxeHnjbZR6KGG|c3H5 M2\qfGlEPTBiPTCwMlAzPSEQvF2= MnjmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
PC3 NWnFSHBoS3m2b4TvfIlkcXS7IHHzd4F6 MXrJR|UxKD1iMD6wO|ch|ryP MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOUC2OUc,OTd2MUmwOlU9N2F-
LoVo M{H2fWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFnyNYxKSzVyIE2gNE4xQSEQvF2= MnTFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
L2987 NH;mdnZEgXSxdH;4bYNqfHliYYPzZZk> M3rObmlEPTBiPTCwMlIh|ryP NF7JU|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxPVA3PSd-MUe0NVkxPjV:L3G+
cells MYrDfZRwfG:6aXPpeJkh[XO|YYm= NWjaVWR1UUN3MDC9JFAvODB3OTFOwG0> M2P5Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NESyOVc4Lz5zN{S0NlU4PzxxYU6=
cells Mle5R5l1d3SxeHnjbZR6KGG|c3H5 NGCwXZpKSzVyIE2gNE4xOSEQvF2= Mn73QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEWyNFcoRjF5NEi1NlA4RC:jPh?=
A2780 MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGHGN5FKSzVyIE2gNE4xODJ6IN88US=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
VA13 NVK0[ZFkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXnJR|UxKD1iMD6wNFUh|ryP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
WI38 NXLtTINlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2exW2lEPTBiPTCwMlA1KM7:TR?= NWXkRXZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVA5PzhpPkG3OFkxQDd6PD;hQi=>
2780AD NX\mT4lLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIjlV|BKSzVyIE2gNE4yQDNizszN MmW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUC4O|goRjF5NEmwPFc5RC:jPh?=
HepG2 MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFHRNFhKSzVyIE2gPE4yKM7:TR?= M3vtbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEmwPFc5Lz5zN{S5NFg4QDxxYU6=
HT29 NG\5U4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MY[0PEBp M3X2c2dKPTBiPTCwMlAyPSEQvF2= NHHKfoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5PFk3OCd-MUe0PVg6PjB:L3G+
M21 MoLvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUC0PEBp MWXHTVUxKD1iMD6wN|ch|ryP M3rlVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEm4PVYxLz5zN{S5PFk3ODxxYU6=
MCF7 NYfBbIRsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYO0PEBp MnnLS2k2OCB;IECuNFU1KM7:TR?= MofrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUi5OlAoRjF5NEm4PVYxRC:jPh?=
1A9 M{ex[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVHkWJE{PzJiaB?= MoT5S2k2OCB;IECuNFAxPzFizszN MkT0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEK1O|IoRjF5NUSyOVczRC:jPh?=
1A9/Ptx22 NYTDT2NmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXW3NkBp M1[5e2dKPTBiPTCwMlA2OSEQvF2= NULOVHNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OFI2PzJpPkG3OVQzPTd{PD;hQi=>
1A9/Ptx10 NFrrWWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUnhTpRnPzJiaB?= NH3LfVdIUTVyIE2gNE4xPjRizszN MlvVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEK1O|IoRjF5NUSyOVczRC:jPh?=
cells expressing MRP1 MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWSwUmN{UUN3MDC9JFAvODB{NTFOwG0> NInSU4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W2O|EzOSd-MUe1OlcyOjF:L3G+
cells expressing Pgp/MRP1 MoXkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWDpUlJ[UUN3MDC9JFIvPyEQvF2= NYPNUXpGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlcyOjFpPkG3OVY4OTJzPD;hQi=>
VA13 NHfMcWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVnJR|UxKD1iNTFOwG0> NFzWeJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W5OVE{PCd-MUe1PVUyOzR:L3G+
MCF7 NHPwfJZHfW6ldHnvckBie3OjeR?= MnjvTWM2OCB;IECuNFAyQCEQvF2= NEXwRpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wNVc{QSd-MUe2NFE4Ozl:L3G+
adriamycin-resistant MCF7 NVj5fZh5TnWwY4Tpc44h[XO|YYm= MVvJR|UxKD1iOD6yJO69VQ>? MoL1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MEG3N|koRjF5NkCxO|M6RC:jPh?=
RPMI8226 MkLUR5l1d3SxeHnjbZR6KGG|c3H5 NXHWRZY2T0l3MDC9JFAvODB{IN88US=> NUTMTHRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
HT29 NITIS49EgXSxdH;4bYNqfHliYYPzZZk> NWDTepZlT0l3MDC9JFAvODB{IN88US=> M1rqNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
COLO205 NVziWFJXS3m2b4TvfIlkcXS7IHHzd4F6 M17NbWdKPTBiPTCwMlAxOyEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
HCC2998 M1f5OGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUjkU|A5T0l3MDC9JFAvODB|IN88US=> MlPsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
HS578T MWjDfZRwfG:6aXPpeJkh[XO|YYm= MXTHTVUxKD1iMD6wNFMh|ryP NWLYWINQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
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SNB75 MonYR5l1d3SxeHnjbZR6KGG|c3H5 MnjwS2k2OCB;IECuNFA1KM7:TR?= M3jUfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
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KM12 NHTGdVBEgXSxdH;4bYNqfHliYYPzZZk> M1\WUmdKPTBiPTCwMlAxPCEQvF2= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
DU145 NWPFXVlsS3m2b4TvfIlkcXS7IHHzd4F6 NHnvfWJIUTVyIE2gNE4xODVizszN M1;lTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
SK-OV3 NHfDNXlEgXSxdH;4bYNqfHliYYPzZZk> M3r6cWdKPTBiPTCwMlAxQCEQvF2= NULuPIs6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
NCI-H322M NWXYTGRCS3m2b4TvfIlkcXS7IHHzd4F6 NWHjZ48zT0l3MDC9JFAvODF|IN88US=> M3;sfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
UACC257 NVP3Um04S3m2b4TvfIlkcXS7IHHzd4F6 NF7mUldIUTVyIE2gNE4xPCEQvF2= MnnDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
HCT15 NFTZXYdEgXSxdH;4bYNqfHliYYPzZZk> Mo\PS2k2OCB;IECuNVU5KM7:TR?= NXHKNnNkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
ACHN Ml;WR5l1d3SxeHnjbZR6KGG|c3H5 NX7k[G5DT0l3MDC9JFAvOzl6IN88US=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
HeLa MkK3R5l1d3SxeHnjbZR6KGG|c3H5 NYnUVpJ1UUN3MDC9JFAvODB3NjFOwG0> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd4NEG0PEc,OTd5NkSxOFg9N2F-
MCF7 M2KxUWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUnr[IdUUUN3MDC9JFAvODF{NDFOwG0> M4HFflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{[0NVQ5Lz5zN{e2OFE1QDxxYU6=
A549 M{K3fmN6fG:2b4jpZ4l1gSCjc4PhfS=> Mk\3TWM2OCB;IECuNFEzPiEQvF2= NYr6U2txRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3OlQyPDhpPkG3O|Y1OTR6PD;hQi=>
HGC27 MXnDfZRwfG:6aXPpeJkh[XO|YYm= NGnFNZRKSzVyIE2gNE44Pzd6IN88US=> NXTjTlZ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3OlQyPDhpPkG3O|Y1OTR6PD;hQi=>
HL60 NXeyfFBsS3m2b4TvfIlkcXS7IHHzd4F6 NEDSNVg4OiCq NUez[pdpUUN3MDC9JFAvQTNizszN M3O0V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OEm2PFE3Lz5zN{i5OlgyPjxxYU6=
P388 MWfDfZRwfG:6aXPpeJkh[XO|YYm= NWXuPW5GPzJiaB?= M{XJ[mlEPTBiPTCwMlk{KM7:TR?= M1viSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OEm2PFE3Lz5zN{i5OlgyPjxxYU6=
BEL-7402 MUjDfZRwfG:6aXPpeJkh[XO|YYm= Mn61NlQhcA>? MYXJR|UxKD1iMD65N{DPxE1? MlLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OU[4NVYoRjF5OEm2PFE3RC:jPh?=
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HepG2 MWTDfZRwfG:6aXPpeJkh[XO|YYm= M2r3PGlEPTBiPTCwMlgzKM7:TR?= M13YOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUGxNFE4Lz5zN{mxNVAyPzxxYU6=
BGC823 MmO1R5l1d3SxeHnjbZR6KGG|c3H5 NV\OV2xUUUN3MDC9JFEvOTVizszN MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzMUCxO{c,OTd7MUGwNVc9N2F-
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PT45 M{\Ge2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUi3NkBp MVXJR|UxKD1iMD6wNFUh|ryP MlHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
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MCF7 NX7MfpdJS3m2b4TvfIlkcXS7IHHzd4F6 NFu2UJY4OiCq NYq5SlVlUUN3MDC9JFAvODB5IN88US=> NGPBOnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
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Ovcar3 MlHhR5l1d3SxeHnjbZR6KGG|c3H5 MYO3NkBp MXXJR|UxKD1iMD6wNUDPxE1? NXLCOYw4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
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A549T12 M1n6d2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVvheVZ7PzJiaB?= MkTMTWM2OCB;IECuNFYh|ryP M{\iTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
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A549T24 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MUK3NkBp NHHz[WRKSzVyIE2gNE4yODJizszN MkjYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
OE33 NVHxeIlPS3m2b4TvfIlkcXS7IHHzd4F6 Ml74O|IhcA>? NF7veVNKSzVyIE2gNE4zKM7:TR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
HepG2 NVfnW4wxS3m2b4TvfIlkcXS7IHHzd4F6 NXriPHpQPzJiaB?= M3LkfGlEPTBiPTCwMlMh|ryP MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
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L12 NV\OPIRySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NX\ycHhMPDhiaB?= MWrJR|UxKD1iMD6wNFYh|ryP NVXOfY53RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5O|M{PjFpPkG3PVc{OzZzPD;hQi=>
NCI-H460 MWnDfZRwfG:6aXPpeJkh[XO|YYm= M1rTXlQ5KGh? NEjOWYhKSzVyIE2gNE4xOSEQvF2= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
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cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis MW\D[YxtKGO7Y3zlJIFzemW|dDDhd5NigQ>? MUXFR|UxKD1iMD6wOFkh|ryP MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
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cells after 48 hrs by XTT assay M3H5OGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MU\JR|UxKD1iMD60JO69VQ>? M2T5WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
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BGC823 MnHuR5l1d3SxeHnjbZR6KGG|c3H5