Paclitaxel

For research use only. Not for use in humans.

目录号:S1150 别名: NSC 125973, PTX, Taxol, Onxal 中文名称:紫杉醇

Paclitaxel Chemical Structure

CAS No. 33069-62-4

Paclitaxel (NSC 125973, PTX, Taxol, Onxal)是一种microtubule聚合物稳定剂,在人内皮细胞中IC50为0.1 pM。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 749.07 现货
RMB 571.49 现货
RMB 2235.46 现货
RMB 3849.3 现货
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客户使用Selleck生产的Paclitaxel发表文献220篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Paclitaxel (NSC 125973, PTX, Taxol, Onxal)是一种microtubule聚合物稳定剂,在人内皮细胞中IC50为0.1 pM。
特性 Paclitaxel 是有丝分裂抑制剂。
靶点
Microtubule (human endothelial cells) [1]
0.1 pM
体外研究

Paclitaxel在104到 105倍更高浓度时,抑制非内皮性人类细胞,IC50 为1 nM -10 nM。Paclitaxel选择性抑制细胞增殖,具有种属特异性,在Paclitaxel极低浓度时,小鼠内皮细胞对 Paclitaxel不敏感。 极低浓度Paclitaxel抑制 人类内皮细胞,但是不影响细胞微管结构,且处理的细胞在 G2/M 期没有出现细胞周期停滞和凋亡,说明这是一种新型尚未查明的作用机制。在体外血管生成实验中,在三维纤维蛋白基质中,极低浓度Paclitaxel阻断人类内皮细胞形成芽管。[1] 在SMF存在时, Paclitaxel 作用于 K562 细胞的有效浓度从50 ng/ml降低到 10 ng/ml。在有或无SMF时,Paclitaxel 使K562 细胞周期停滞与DNA损伤相关。[2] Paclitaxel单独处理四种细胞系,包括A549 细胞,H358, H1395 细胞和H1666 细胞,抑制CDK1,这种作用存在时间依赖性。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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WSU-NHL M3i4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn5c|dKSzVyIE2gNlUvPzJ4MTFOwG0> NV7M[nlFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
TUR NWXK[IRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxKD1iMk[uOlU{OyEQvF2= NHz0VYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
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KG-1 NV\oNYh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnruTWM2OCB;IEK4MlI5PjVizszN NHzLfHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
P31-FUJ MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxKD1iMkmuNFQ5QSEQvF2= MlnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
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COLO205 MlvUR5l1d3SxeHnjbZR6KGG|c3H5 NUT6PWM{T0l3MDC9JFAvODBzN{[g{txO NXnicI95RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
SF539 NFi2dJFEgXSxdH;4bYNqfHliYYPzZZk> M2ruT2dKPTBiPTCwMlAxOzZ4IN88US=> NUTK[4R6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
SNB75 NUjkdG9rS3m2b4TvfIlkcXS7IHHzd4F6 MU\HTVUxKD1iMD6wNFgxQCEQvF2= NWDhPFc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
DMS114 NEG4ZW9EgXSxdH;4bYNqfHliYYPzZZk> MVXHTVUxKD1iMD6wNVI{KM7:TR?= NWTLRpZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
OVCAR-3 Ml:wR5l1d3SxeHnjbZR6KGG|c3H5 M33WO2dKPTBiPTCwMlAyQTdizszN NE\rWFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
NCI-H460 NYLSdnd{S3m2b4TvfIlkcXS7IHHzd4F6 MV3HTVUxKD1iMD6wNlE6KM7:TR?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
HOP62 NYO1dIpYS3m2b4TvfIlkcXS7IHHzd4F6 M{PCbGdKPTBiPTCwMlA3PzFizszN M3LIRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd7MEi5OVAoRjd7MEi5OVA9N2F-
mammary carcinoma NY\LcFlxS3m2b4TvfIlkcXS7IHHzd4F6 NYrjfG9GUUN3MDC9JFAvOjl7IN88US=> NHrXUlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96MUiyOlk5Lz56MUiyOlk5RC:jPh?=
NCI60 MlPxR5l1d3SxeHnjbZR6KGG|c3H5 M2SyfGdKPTBiPTCwMlAxODZ3IN88US=> NUHiPW5mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUS2NVY2Oyd-OUS2NVY2OzxxYU6=
MCF-7 NXPjbY5QT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1H6VWdKPTBiPTCwMlAxOTFizszN MoXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh5M{W5O{c,QTh5M{W5O|ww[T5?
murine leukemic P388 M2LSUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3TE[WdKPTBiPTCwMlAyPiEQvF2= NVTlUlZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3N|U6Pyd-OUi3N|U6PzxxYU6=
KB NV64PIlQS3m2b4TvfIlkcXS7IHHzd4F6 NVnjcG9YUUN3MDC9JFAvODB4IN88US=> NGWye3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEm3PFIxOCd-MUC5O|gzODB:L3G+
MCF7 Mlm5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4ix[|czKGh? NEDnVodKSzVyIE2gNE4xODJizszN NIfxXIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOyOVIzPid-MUGzNlUzOjZ:L3G+
MCF-7 NHzyUnNEgXSxdH;4bYNqfHliYYPzZZk> NYe1VmpmTUR3MDC9JFAvODB2IN88US=> NWSzc3VuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjdpPkGxN|M1PTZ5PD;hQi=>
uterine sarcoma (MES-SA) NGHVNIZEgXSxdH;4bYNqfHliYYPzZZk> NV3LcWw6UUN3MDC9JFAvODByMESg{txO M{jTUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{K4NVkyLz5zMUeyPFE6OTxxYU6=
nonsmall cell lung carcinoma (NCI-H460) M{GxNWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3zxTGlEPTBiPTCwMlAxODF2IN88US=> M13qW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{K4NVkyLz5zMUeyPFE6OTxxYU6=
colon adenocarcinoma (HT-29) M3nBPWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nYcGlEPTBiPTCwMlAxODF4IN88US=> NHf6XIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUeyPFE6OSd-MUG3NlgyQTF:L3G+
prostate carcinoma (DU-145) Mmr2R5l1d3SxeHnjbZR6KGG|c3H5 M4LXbmlEPTBiPTCwMlAxPDh7IN88US=> M3TyV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{K4NVkyLz5zMUeyPFE6OTxxYU6=
SW626 NF\5UZVEgXSxdH;4bYNqfHliYYPzZZk> NEjNTW04OiCq Ml2wTWM2OCB;IECuNFAxODFizszN Mn;jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
Lu1 MUnDfZRwfG:6aXPpeJkh[XO|YYm= M1X0PVczKGh? M{C5SGlEPTBiPTCwMlAyKM7:TR?= Mn76QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
MCF7 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MkTXO|IhcA>? NF7vO3lKSzVyIE2gNE4xOiEQvF2= M3zrV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
P388 MXHDfZRwfG:6aXPpeJkh[XO|YYm= NFjaWZA4OiCq NUO4[nMzUUN3MDC9JFAvODJizszN NWnXeIEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
LNCAP MW\DfZRwfG:6aXPpeJkh[XO|YYm= MUW3NkBp M17Ve2lEPTBiPTCwMlAzKM7:TR?= NGDkdXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
KB NFTsVZlEgXSxdH;4bYNqfHliYYPzZZk> NYnoem9ZPzJiaB?= NIGxdGtKSzVyIE2gNE4xOiEQvF2= NGO2T3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
Col2 NYHWcoZ3S3m2b4TvfIlkcXS7IHHzd4F6 MYS3NkBp NHvKe4tKSzVyIE2gNE4xOiEQvF2= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
BC1 M2m4WmN6fG:2b4jpZ4l1gSCjc4PhfS=> NF:5bWg4OiCq MULJR|UxKD1iMD6wNkDPxE1? NXLWeFdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
SK-MEL-2 MYPDfZRwfG:6aXPpeJkh[XO|YYm= Mni5O|IhcA>? NFHpZmFKSzVyIE2gNE4xPyEQvF2= NFfsXoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
L2987 NWPZWWlQS3m2b4TvfIlkcXS7IHHzd4F6 NY\V[5hCUUN3MDC9JFAvOiEQvF2= M4DoPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NESzO|g{Lz5zMkS0N|c5OzxxYU6=
colon adenocarcinoma RKO M4q5VGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUnJR|UxKD1iMD6wNUDPxE1? M1HZOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEWyO|Y5Lz5zMki1Nlc3QDxxYU6=
NCI-H460 NX7pfJlFS3m2b4TvfIlkcXS7IHHzd4F6 NUfOR5RPPDhiaB?= NFrRbFJKSzVyIE2gNE4xODl3IN88US=> M4LpSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2Nkm1O|k5Lz5zNE[5OVc6QDxxYU6=
MCF7 NFvMOY9EgXSxdH;4bYNqfHliYYPzZZk> M1\lNVQ5KGh? M4HqcWlEPTBiPTCwMlAyOTJizszN M4DBZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2Nkm1O|k5Lz5zNE[5OVc6QDxxYU6=
SF268 MmnwR5l1d3SxeHnjbZR6KGG|c3H5 MX20PEBp M2jMXWlEPTBiPTCwMlAzOTdizszN NIrEOmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[5OVc6QCd-MUS2PVU4QTh:L3G+
MDA-MB-231 M2rTb2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVTJN3pCPDhiaB?= NILuVolKSzVyIE2gNE4xODR3IN88US=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1NUc,OTR7OEewOVE9N2F-
MCF7 M1rRV2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mn;DOFghcA>? M4PwUmlEPTBiPTCwMlAxPDlizszN NHPBSmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm4O|A2OSd-MUS5PFcxPTF:L3G+
A2780 NVjLO5BrS3m2b4TvfIlkcXS7IHHzd4F6 NYHP[mJ1PDhiaB?= M3LVOWlEPTBiPTCwMlAzPSEQvF2= NYfFNI5oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTFpPkG0PVg4ODVzPD;hQi=>
PC3 NHq3RWNEgXSxdH;4bYNqfHliYYPzZZk> M125[|Q5KGh? NH\ZT41KSzVyIE2gNE4xPzdizszN M{PzXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUi3NFUyLz5zNEm4O|A2OTxxYU6=
MCF7 NGHKc4tEgXSxdH;4bYNqfHliYYPzZZk> NX3WPW04PzJiaB?= NWX6eIlDUUN3MDC9JFAvODBzNDFOwG0> M3v5e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUi3NFU3Lz5zNEm4O|A2PjxxYU6=
multidrug-resistant MCF7 NV;4dFl2S3m2b4TvfIlkcXS7IHHzd4F6 MkfVO|IhcA>? NXf3V5BFUUN3MDC9JFAvOzV2IN88US=> Ml;HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVYoRjF2OUi3NFU3RC:jPh?=
PC3 NFWyWlBEgXSxdH;4bYNqfHliYYPzZZk> MVy0PEBp MlX1TWM2OCB;IECuNFE3KM7:TR?= NE\MeIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxOid-MUWwOFM1ODJ:L3G+
Hep3B NVPOZYI4S3m2b4TvfIlkcXS7IHHzd4F6 NWLxZVVxPDhiaB?= M37MUmlEPTBiPTCwMlA{OSEQvF2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwNkc,OTVyNEO0NFI9N2F-
NCI-H460 NEnDZ41EgXSxdH;4bYNqfHliYYPzZZk> M3Lh[FQ5KGh? NEXFTZhKSzVyIE2gNE4xODl3IN88US=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwOEc,OTVyNEO0NFQ9N2F-
MCF7 MmX5R5l1d3SxeHnjbZR6KGG|c3H5 NYHLNmZRPDhiaB?= NV3Id5ZSUUN3MDC9JFAvODFzMjFOwG0> M2Pld|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA1Lz5zNUC0N|QxPDxxYU6=
SF268 M{n1WGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmfZOFghcA>? MV\JR|UxKD1iMD6wNlE4KM7:TR?= M4PTcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA1Lz5zNUC0N|QxPDxxYU6=
KB NWPlcpo1S3m2b4TvfIlkcXS7IHHzd4F6 M{j5WmVFPTBiPTCwMlAxODRizszN NESzdIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
Lu1 MYrDfZRwfG:6aXPpeJkh[XO|YYm= M{TlWGVFPTBiPTCwMlAxOiEQvF2= NIT1T5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
LNCAP NH7MdXZEgXSxdH;4bYNqfHliYYPzZZk> MXTFSFUxKD1iMD6wNFUh|ryP NX3ncmFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
RPE1 NIXjOWlEgXSxdH;4bYNqfHliYYPzZZk> M17SZWVFPTBiPTCwMlAzOyEQvF2= MmTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
Col2 MlPxR5l1d3SxeHnjbZR6KGG|c3H5 NWn2doJXTUR3MDC9JFAvODR4IN88US=> NXTnVWlXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
T47D MknhRZBweHSxc3nzJIF{e2G7 NI\2SZMzPCCq NUe2SndqTUN3MDC9JFAvODNizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkOwNEc,OTV3Nk[zNFA9N2F-
DLD1 NVrHdYMzSXCxcITvd4l{KGG|c3H5 NFjpZlgzPCCq MV\FR|UxKD1iMD6wO|Uh|ryP M{jDUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NU[2N|AxLz5zNUW2OlMxODxxYU6=
H1299 NWDyTlBPSXCxcITvd4l{KGG|c3H5 M1LoXlI1KGh? M{i4U2VEPTBiPTCwMlE3OyEQvF2= NV\4eYw5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1OlY{ODBpPkG1OVY3OzByPD;hQi=>
VA13 M17xVGN6fG:2b4jpZ4l1gSCjc4PhfS=> MofPOFghcA>? NHXvdVNKSzVyIE2gNE4xODVizszN NHjRWWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUezNFI1Oyd-MUW3N|AzPDN:L3G+
WI 38 NXf3OoE2S3m2b4TvfIlkcXS7IHHzd4F6 MX60PEBp MkLDTWM2OCB;IECuNFQh|ryP NF3tOWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUezNFI1Oyd-MUW3N|AzPDN:L3G+
Hep G2 M{P6UGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn;NOFghcA>? NF7J[3VKSzVyIE2gPE4yKM7:TR?= MkPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5M{CyOFMoRjF3N{OwNlQ{RC:jPh?=
A549 MnL0R5l1d3SxeHnjbZR6KGG|c3H5 NV;tUmxzPDhiaB?= NWH5RZhCUUN3MDC9JFEvOjVizszN MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd6N{S2NEc,OTV5OEe0OlA9N2F-
SKOV3 M2DKV2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVe0PEBp NEjCV5dKSzVyIE2gNU4{PSEQvF2= NVH6flhkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3PFc1PjBpPkG1O|g4PDZyPD;hQi=>
KB M4nxNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYHIbWpVOyCmYYnz MYXJR|UxKD1iMD6wNFEh|ryP NH3ybWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkCzPFU1PSd-MU[wN|g2PDV:L3G+
1A9 NGrXPIZEgXSxdH;4bYNqfHliYYPzZZk> MX[zJIRigXN? MoPFTWM2OCB;IECuNFAzKM7:TR?= NHnEdmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkCzPFU1PSd-MU[wN|g2PDV:L3G+
HCT8 MoPsR5l1d3SxeHnjbZR6KGG|c3H5 MYSzJIRigXN? NH2wOFRKSzVyIE2gNE4xOTNizszN NH;yVok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkCzPFU1PSd-MU[wN|g2PDV:L3G+
A431 M3LXXmNmdGxiY4njcIUh[XK{ZYP0JIF{e2G7 M3TiPGVEPTBiPTCwMlAxQSEQvF2= NUTae5lSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zO|cyQDdpPkG2N|c4OTh5PD;hQi=>
VA13 NUG1eFJ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo[1OFghcA>? NFTlV49KSzVyIE2gNE4xODR|IN88US=> M325TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEm5N|IzLz5zNkS5PVMzOjxxYU6=
WI38 NH\4[mNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml:wOFghcA>? M3vh[WlEPTBiPTCwMlA{PCEQvF2= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjR7OUOyNkc,OTZ2OUmzNlI9N2F-
HepG2 MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYO0PEBp MlrnTWM2OCB;IE[uPUDPxE1? NWH4NYl2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PVk{OjJpPkG2OFk6OzJ{PD;hQi=>
Aro M{m1bWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUmxVpdlUUN3MDC9JFAvODByMjFOwG0> NUfDPWRKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
PT45 NHr6dYxEgXSxdH;4bYNqfHliYYPzZZk> M{W2SWlEPTBiPTCwMlAxPSEQvF2= Mlf5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
A549 NEDsXo9EgXSxdH;4bYNqfHliYYPzZZk> M{nzXmlEPTBiPTCwMlAxPiEQvF2= NGKy[2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
MCF7 MoezR5l1d3SxeHnjbZR6KGG|c3H5 M4C2VGlEPTBiPTCwMlAxPyEQvF2= NE\Denk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
HeLa M2jrfGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4rXV2lEPTBiPTCwMlAxQCEQvF2= Mn3QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
Ovcar3 NWLNc45MS3m2b4TvfIlkcXS7IHHzd4F6 MWLJR|UxKD1iMD6wNUDPxE1? NXTLSGY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
HT29 MXrDfZRwfG:6aXPpeJkh[XO|YYm= NFuxO4RKSzVyIE2gNE4xPSEQvF2= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
H295R NEjDTGZEgXSxdH;4bYNqfHliYYPzZZk> MYLJR|UxKD1iMD6wPEDPxE1? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
BNL NWTnOpZNS3m2b4TvfIlkcXS7IHHzd4F6 NIDWNHZKSzVyIE2gNE4zKM7:TR?= NXTQNZVJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
4T1 NGO4dVlEgXSxdH;4bYNqfHliYYPzZZk> M3fQNmlEPTBiPTCwMlIh|ryP NHr4OXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
HepG2 Mlu3R5l1d3SxeHnjbZR6KGG|c3H5 NInMPHlKSzVyIE2gNE4{KM7:TR?= NXHzephoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
U937 GTB M{LSSWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFjMcHI4OiCq M{WxNWlEPTBiPTCwMlAxPTlizszN NIHHOXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkW2Nlg1OCd-MU[1OlI5PDB:L3G+
RPMI 8226/s M1TUb2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4nURVczKGh? MULJR|UxKD1iMD6wNFch|ryP MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV4Mki0NEc,OTZ3NkK4OFA9N2F-
CEM/s M33WdmN6fG:2b4jpZ4l1gSCjc4PhfS=> M{nwXlczKGh? MXzJR|UxKD1iMD6wNFch|ryP MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV4Mki0NEc,OTZ3NkK4OFA9N2F-
VA13 NY\X[3BUS3m2b4TvfIlkcXS7IHHzd4F6 M4nrcGlEPTBiPTCwMlAxPTlizszN NYmwXVYzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3NlQ5PDJpPkG2O|I1QDR{PD;hQi=>
WI38 Mkf4R5l1d3SxeHnjbZR6KGG|c3H5 M{fTVmlEPTBiPTCwMlA1PjhizszN MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd{NEi0Nkc,OTZ5MkS4OFI9N2F-
HepG2 MU\DfZRwfG:6aXPpeJkh[XO|YYm= NGPiW5RKSzVyIE2gPU41QSEQvF2= NHT3Tmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyOFg1Oid-MU[3NlQ5PDJ:L3G+
HT29 MnPzR5l1d3SxeHnjbZR6KGG|c3H5 Mlj6SWM2OCB;IECuNFA3KM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjh5MESyPEc,OTZ6N{C0Nlg9N2F-
K562 NID4TY9EgXSxdH;4bYNqfHliYYPzZZk> MlPVSWM2OCB;IECuNFE1KM7:TR?= Mo\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ6N{C0NlgoRjF4OEewOFI5RC:jPh?=
MCF7 MWDDfZRwfG:6aXPpeJkh[XO|YYm= NFXXXIVGSzVyIE2gNE4xOzZizszN MkHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ6N{C0NlgoRjF4OEewOFI5RC:jPh?=
VA-13 M1z3bmN6fG:2b4jpZ4l1gSCjc4PhfS=> M13SVWlEPTBiPTCwMlAxPSEQvF2= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl|M{i2PEc,OTZ7M{O4Olg9N2F-
WI38 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MVHJR|UxKD1iMD6wOEDPxE1? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl|M{i2PEc,OTZ7M{O4Olg9N2F-
VA13 MYDDfZRwfG:6aXPpeJkh[XO|YYm= M16yT2lEPTBiPTCwMlAxPSEQvF2= M{PLdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5ME[3NVU2Lz5zN{C2O|E2PTxxYU6=
WI38 NX3sfnltS3m2b4TvfIlkcXS7IHHzd4F6 NWS5WnBkUUN3MDC9JFAvODRizszN M1H6WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5ME[3NVU2Lz5zN{C2O|E2PTxxYU6=
Hep G2 MV3DfZRwfG:6aXPpeJkh[XO|YYm= M3PtXWlEPTBiPTC4MlEh|ryP NYPDS5ZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOlcyPTVpPkG3NFY4OTV3PD;hQi=>
TW01 NGXuTJdEgXSxdH;4bYNqfHliYYPzZZk> MVXJR|UxKD1iMD6wNFA{KM7:TR?= MmrpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzMUOyPFgoRjF5MUGzNlg5RC:jPh?=
MCF7 MnziR5l1d3SxeHnjbZR6KGG|c3H5 MUXJR|UxKD1iMD6wNFA2KM7:TR?= M1f3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MKN45 M3TZbmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYHJR|UxKD1iMD6wNFA2KM7:TR?= NI\jW2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
MES-SA NWTjdXVmS3m2b4TvfIlkcXS7IHHzd4F6 MorHTWM2OCB;IECuNFAxPSEQvF2= NE\xW2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
HCT116 Mnu0R5l1d3SxeHnjbZR6KGG|c3H5 NYnwNWNrUUN3MDC9JFAvODByNjFOwG0> NVrtbmtRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
RPTEC NIP6TmlEgXSxdH;4bYNqfHliYYPzZZk> NHHVRolKSzVyIE2gNE4xODB7IN88US=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
Hep3B M37YWWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3exRWlEPTBiPTCwMlAxPTRizszN MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
NCI-H226 MVPDfZRwfG:6aXPpeJkh[XO|YYm= M4S3e2lEPTBiPTCwMlAxPjhizszN MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
A498 NHLzb|hEgXSxdH;4bYNqfHliYYPzZZk> MVTJR|UxKD1iMD6wOlEh|ryP M1m2W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MDA435/LCC6 MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NVX5fpBxUUN3MDC9JFAvODB{OTFOwG0> NU\oeoJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVQ2ODVpPkG3NVU1PTB3PD;hQi=>
multidrug resistant MDA435/LCC6 M4\ZWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkCzTWM2OCB;IECuNFA1QCEQvF2= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
P388 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXu2d|ZtUUN3MDC9JFAvODJ{IN88US=> NXHQNWc2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVQ2ODVpPkG3NVU1PTB3PD;hQi=>
adriamycin resistant P388 NYr2OnZQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MojvTWM2OCB;IECuNFMh|ryP NHfGNY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1OFUxPSd-MUexOVQ2ODV:L3G+
LT12 NW\aOI9TSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MWC0PEBp MYPJR|UxKD1iMD6wNFYh|ryP M2\RclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
SKOV3 MmPMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MkjZOFghcA>? NXzz[YoyUUN3MDC9JFAvODFizszN M3\MUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
NCI-H460 M3qyPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXe0PEBp M3;GUWlEPTBiPTCwMlAyKM7:TR?= M4L2W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
SF268 M3KweGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGT3[4U1QCCq M3XnVmlEPTBiPTCwMlAyKM7:TR?= MoDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
RKO NWDi[YlrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVz4ZVVzPDhiaB?= NYTHSHd6UUN3MDC9JFAvODFizszN MlH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
KB/HeLa MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWm0PEBp MYDJR|UxKD1iMD6wNUDPxE1? NHKxb5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
P388 Mly3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVnJe5FQPDhiaB?= MXPJR|UxKD1iMD6wOEDPxE1? M37jbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
L1210 NH7yRmZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIqxNnQ1QCCq NX[xR|RMUUN3MDC9JFAvODZizszN M2TQc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
LT12 MDR MoLERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3zvNlQ5KGh? Mm\YTWM2OCB;IECuOEDPxE1? M1jBUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
A2780 NYHUOVM1S3m2b4TvfIlkcXS7IHHzd4F6 MXjJR|UxKD1iMD6wNFEh|ryP NInjNpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KwOlE{QSd-MUeyNFYyOzl:L3G+
A2780-1A9 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MWrJR|UxKD1iMD6wNFEyKM7:TR?= NWLwTpFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNFYyOzlpPkG3NlA3OTN7PD;hQi=>
A549 NGnlfGlEgXSxdH;4bYNqfHliYYPzZZk> MoXxTWM2OCB;IECuNFA{PiEQvF2= MoP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
1A9PTX22 MVnDfZRwfG:6aXPpeJkh[XO|YYm= M3vETmlEPTBiPTCwMlAyQSEQvF2= Moi3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
1A9PTX10 M4LMVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWHvflRrUUN3MDC9JFAvODNizszN NUfxN2ZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNFYyOzlpPkG3NlA3OTN7PD;hQi=>
A2780AD NILh[FREgXSxdH;4bYNqfHliYYPzZZk> MWrJR|UxKD1iMD65JO69VQ>? MkS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
KB MlXlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWi3XFl{UUN3MDC9JFAvODB{NEWg{txO MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ{OEi3N{c,OTd{Mki4O|M9N2F-
COLO205 NIrtTWdEgXSxdH;4bYNqfHliYYPzZZk> Ml73TWM2OCB;IECuNFA{OyEQvF2= M3H5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkK4PFc{Lz5zN{KyPFg4OzxxYU6=
KB8.5 NE\BUHhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmXlTWM2OCB;IECuNFI3KM7:TR?= NXfIfZVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNlg5PzNpPkG3NlI5QDd|PD;hQi=>
KBV1 NIPRO|ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmX4TWM2OCB;IEKuNFE{KM7:TR?= NGXkOlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KyPFg4Oyd-MUeyNlg5PzN:L3G+
A2780 MnXkR5l1d3SxeHnjbZR6KGG|c3H5 NYXpeVN7UUN3MDC9JFAvODByNzFOwG0> M{jKdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkO5OVk4Lz5zN{KzPVU6PzxxYU6=
2780AD MXXDfZRwfG:6aXPpeJkh[XO|YYm= MoizTWM2OCB;IECuOVM2KM7:TR?= M{jiXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkO5OVk4Lz5zN{KzPVU6PzxxYU6=
1A9 M1jYfWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnjjSWQ2OCB;IECuNFAyKM7:TR?= Mn3nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
MCF7 NXK1eoNHS3m2b4TvfIlkcXS7IHHzd4F6 MmHWSWQ2OCB;IECuNFAyOSEQvF2= NEfUW209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O1NFg{PCd-MUezOVA5OzR:L3G+
DU145 Mnf6R5l1d3SxeHnjbZR6KGG|c3H5 MXPFSFUxKD1iMD6wNFE{KM7:TR?= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
KB Ml7NR5l1d3SxeHnjbZR6KGG|c3H5 NFjFN4FGTDVyIE2gNE4xODF6IN88US=> MkS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
A549 M1LkWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYHFSFUxKD1iMD6wNFI{KM7:TR?= M1HIVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
LNCAP M{LLNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NEPNNXlGTDVyIE2gNE4xODJ4IN88US=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
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A2780/AD M4\QfGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUjJR|UxKD1iMD65NkDPxE1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN7NUS2OUc,OTd|OUW0OlU9N2F-
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COLO205 MmX2R5l1d3SxeHnjbZR6KGG|c3H5 M4[5N2lEPTBiPTCwMlAxOzNizszN MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
KB8.5 NH\JeXlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVrJR|UxKD1iMD6wNlYh|ryP M2O4W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVI1Lz5zN{SxOlUzPDxxYU6=
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neural precursor NHP4NIdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NGHmV4dGSzVyIE2gNE4xOSEQvF2= M2TsV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
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MDA-MB-231 NIi5OVhEgXSxdH;4bYNqfHliYYPzZZk> NWLMNYJLUUN3MDC9JFAvODB2NTFOwG0> MlfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
MCF7 MWnDfZRwfG:6aXPpeJkh[XO|YYm= M3\SZmlEPTBiPTCwMlAxPDlizszN M1\DN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG5NFY2Lz5zN{SxPVA3PTxxYU6=
NCI-H1299 NWLjO5M1S3m2b4TvfIlkcXS7IHHzd4F6 MV[5OkBp NXXvcpVXUUN3MDC9JFAvODF3IN88US=> MoDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
A2780 NEXjOpBEgXSxdH;4bYNqfHliYYPzZZk> NXTwV3FFUUN3MDC9JFAvODJ3IN88US=> NYPoWpNLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
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LoVo M1K1S2N6fG:2b4jpZ4l1gSCjc4PhfS=> MU\JR|UxKD1iMD6wPUDPxE1? NX[xS2YyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
L2987 NXfTW5FJS3m2b4TvfIlkcXS7IHHzd4F6 NE\S[XpKSzVyIE2gNE4zKM7:TR?= NXzJdphuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
cells NVXoPGU5S3m2b4TvfIlkcXS7IHHzd4F6 MV3JR|UxKD1iMD6wNFU6KM7:TR?= NFezSFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0NlU4Pyd-MUe0OFI2Pzd:L3G+
cells NXPYZY02S3m2b4TvfIlkcXS7IHHzd4F6 NY\hc5JuUUN3MDC9JFAvODFizszN MnHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEWyNFcoRjF5NEi1NlA4RC:jPh?=
A2780 MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYDJR|UxKD1iMD6wNFI5KM7:TR?= M{LLclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEmwPFc5Lz5zN{S5NFg4QDxxYU6=
VA13 NF62ZW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUe0ZXNwUUN3MDC9JFAvODB3IN88US=> MnTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUC4O|goRjF5NEmwPFc5RC:jPh?=
WI38 NXjiXm1wT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFnZeIVKSzVyIE2gNE4xPCEQvF2= M36wUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEmwPFc5Lz5zN{S5NFg4QDxxYU6=
2780AD NFP0cG1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIjWdWFKSzVyIE2gNE4yQDNizszN NHHZd209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5NFg4QCd-MUe0PVA5Pzh:L3G+
HepG2 Mn\0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYLJR|UxKD1iOD6xJO69VQ>? NVXJPFJ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVA5PzhpPkG3OFkxQDd6PD;hQi=>
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MCF7 M1vQZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoLzOFghcA>? MXnHTVUxKD1iMD6wOVQh|ryP MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7OEm2NEc,OTd2OUi5OlA9N2F-
1A9 MlPZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXi3NkBp NW\jcoNrT0l3MDC9JFAvODByN{Gg{txO M13lR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUSyOVczLz5zN{W0NlU4OjxxYU6=
1A9/Ptx22 MknHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH7wNWs4OiCq MlXmS2k2OCB;IECuNFUyKM7:TR?= M{jvVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUSyOVczLz5zN{W0NlU4OjxxYU6=
1A9/Ptx10 NUD6eFhST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEDwb484OiCq M{fNZmdKPTBiPTCwMlA3PCEQvF2= M2fkXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUSyOVczLz5zN{W0NlU4OjxxYU6=
cells expressing MRP1 NYXuR4hXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmXjTWM2OCB;IECuNFAzPSEQvF2= NVPWWZFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlcyOjFpPkG3OVY4OTJzPD;hQi=>
cells expressing Pgp/MRP1 NH\lTI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4XYbmlEPTBiPTCyMlch|ryP NVXFN29iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlcyOjFpPkG3OVY4OTJzPD;hQi=>
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MCF7 NWHyfHpvTnWwY4Tpc44h[XO|YYm= M1H3ZmlEPTBiPTCwMlAxOThizszN NFW1TYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wNVc{QSd-MUe2NFE4Ozl:L3G+
adriamycin-resistant MCF7 NWXr[2x5TnWwY4Tpc44h[XO|YYm= M2roWWlEPTBiPTC4MlIh|ryP M3fqNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkCxO|M6Lz5zN{[wNVc{QTxxYU6=
RPMI8226 NYWyXnBjS3m2b4TvfIlkcXS7IHHzd4F6 Mon4S2k2OCB;IECuNFAzKM7:TR?= MlfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
HT29 M12zcGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mm\nS2k2OCB;IECuNFAzKM7:TR?= NXfZcWMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
COLO205 NF:1SHNEgXSxdH;4bYNqfHliYYPzZZk> NV;lW|hyT0l3MDC9JFAvODB|IN88US=> NXfDVpVYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
HCC2998 MmLjR5l1d3SxeHnjbZR6KGG|c3H5 NXjLXlc3T0l3MDC9JFAvODB|IN88US=> M1GwNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
HS578T NVzKb5RwS3m2b4TvfIlkcXS7IHHzd4F6 Mkj2S2k2OCB;IECuNFA{KM7:TR?= MnHqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
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SNB75 M1XVe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVnHTVUxKD1iMD6wNFQh|ryP NHzu[Y49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
A549 MkfyR5l1d3SxeHnjbZR6KGG|c3H5 MkjhS2k2OCB;IECuNFA1KM7:TR?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
KM12 MUXDfZRwfG:6aXPpeJkh[XO|YYm= M3jmc2dKPTBiPTCwMlAxPCEQvF2= M{eyb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
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NCI-H322M MVLDfZRwfG:6aXPpeJkh[XO|YYm= NHvKTmpIUTVyIE2gNE4xOTNizszN M131bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
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ACHN M1j3dGN6fG:2b4jpZ4l1gSCjc4PhfS=> NX;QcohOT0l3MDC9JFAvOzl6IN88US=> MoXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
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MCF7 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MkXkTWM2OCB;IECuNFEzPCEQvF2= M3f1flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{[0NVQ5Lz5zN{e2OFE1QDxxYU6=
A549 MlnJR5l1d3SxeHnjbZR6KGG|c3H5 MVfJR|UxKD1iMD6wNVI3KM7:TR?= M13HbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{[0NVQ5Lz5zN{e2OFE1QDxxYU6=
HGC27 NXPHV5RlS3m2b4TvfIlkcXS7IHHzd4F6 Mm\CTWM2OCB;IECuO|c4QCEQvF2= NF;m[FY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{e2OFE1QCd-MUe3OlQyPDh:L3G+
HL60 NXLTbnJlS3m2b4TvfIlkcXS7IHHzd4F6 MXy3NkBp M1TvemlEPTBiPTCwMlk{KM7:TR?= Ml;BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OU[4NVYoRjF5OEm2PFE3RC:jPh?=
P388 MWLDfZRwfG:6aXPpeJkh[XO|YYm= MkjGO|IhcA>? NGizS2dKSzVyIE2gNE46OyEQvF2= Mo\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OU[4NVYoRjF5OEm2PFE3RC:jPh?=
BEL-7402 NITTVZFEgXSxdH;4bYNqfHliYYPzZZk> NEj2TFMzPCCq M4DpV2lEPTBiPTCwMlk{KM7:TR?= M1W4b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OEm2PFE3Lz5zN{i5OlgyPjxxYU6=
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HeLa MoHTR5l1d3SxeHnjbZR6KGG|c3H5 Mly4TWM2OCB;IECuNFIh|ryP MmTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUGwNVcoRjF5OUGxNFE4RC:jPh?=
HepG2 NF3oOmNEgXSxdH;4bYNqfHliYYPzZZk> MnTjTWM2OCB;IECuPFIh|ryP MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzMUCxO{c,OTd7MUGwNVc9N2F-
BGC823 M4q4SWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVXJR|UxKD1iMT6xOUDPxE1? Mn7LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUGwNVcoRjF5OUGxNFE4RC:jPh?=
Aro NX;KU5VrS3m2b4TvfIlkcXS7IHHzd4F6 NULDc2g6PzJiaB?= M1HiN2lEPTBiPTCwMlAxODJizszN M3Ly[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
PT45 MmXSR5l1d3SxeHnjbZR6KGG|c3H5 M{i1WFczKGh? NHnTcnVKSzVyIE2gNE4xODVizszN NGPCUlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
A549 NXPoVG9xS3m2b4TvfIlkcXS7IHHzd4F6 MoC3O|IhcA>? MoHoTWM2OCB;IECuNFA3KM7:TR?= NILoT5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
MCF7 NUTBTVdsS3m2b4TvfIlkcXS7IHHzd4F6 NV61XGpxPzJiaB?= NH3OeZpKSzVyIE2gNE4xODdizszN MnLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
HeLa M4W2VWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2TzfFczKGh? NES2O5FKSzVyIE2gNE4xODhizszN Mn3MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
Ovcar3 Mn7OR5l1d3SxeHnjbZR6KGG|c3H5 NXfYZ41VPzJiaB?= NY[wZXp2UUN3MDC9JFAvODFizszN Moq5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
HT29 Mn:yR5l1d3SxeHnjbZR6KGG|c3H5 MoryO|IhcA>? MYrJR|UxKD1iMD6wOUDPxE1? NHrIZpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
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H295R NGTkOIdEgXSxdH;4bYNqfHliYYPzZZk> MmHnO|IhcA>? MUTJR|UxKD1iMD6wPEDPxE1? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
A549T24 NHHBO5NEgXSxdH;4bYNqfHliYYPzZZk> M33zbVczKGh? NGrObG5KSzVyIE2gNE4yODJizszN MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
OE33 NXLOd2hvS3m2b4TvfIlkcXS7IHHzd4F6 M4WwclczKGh? M13WUmlEPTBiPTCwMlIh|ryP NE[wRZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
HepG2 MWjDfZRwfG:6aXPpeJkh[XO|YYm= NEnwfHU4OiCq MkTmTWM2OCB;IECuN{DPxE1? NGP0TnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
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L12 Mn7JRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2jwZlQ5KGh? M{LqSmlEPTBiPTCwMlAxPiEQvF2= MmTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
NCI-H460 M3rX[WN6fG:2b4jpZ4l1gSCjc4PhfS=> NGnGdFU1QCCq Mn;KTWM2OCB;IECuNFEh|ryP MnXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
SKOV3 Mkf5R5l1d3SxeHnjbZR6KGG|c3H5 MmTYOFghcA>? M2XzU2lEPTBiPTCwMlAyKM7:TR?= NF\k[5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
SF268 M3jyXmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXy0PEBp MmjXTWM2OCB;IECuNFEh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
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P388 M2PnV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlLyOFghcA>? MkH3TWM2OCB;IECuNFQh|ryP M4m0PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis M{fzU2NmdGxiY4njcIUh[XK{ZYP0JIF{e2G7 M4H4emVEPTBiPTCwMlA1QSEQvF2= MlXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
L1210 NUjmWGxCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWntWnFTPDhiaB?= MUjJR|UxKD1iMD6wOkDPxE1? M{facVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
cells after 48 hrs by XTT assay NUHZTZZ7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmmzTWM2OCB;IECuOEDPxE1? MkXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
A2780 MknnR5l1d3SxeHnjbZR6KGG|c3H5 MXXJR|UxKD1iMD6wNFY{KM7:TR?= Ml;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyMEGwPFcoRjF6MECxNFg4RC:jPh?=
BGC823 MmPFR5l1d3SxeHnjbZR6KGG|c3H5 NELMZZNKSzVyIE2gNE4xODdizszN MmO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyMEGwPFcoRjF6MECxNFg4RC:jPh?=
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Bel7402 MoTJR5l1d3SxeHnjbZR6KGG|c3H5 MoXrTWM2OCB;IECuNUDPxE1? NHTtdJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOECwNVA5Pyd-MUiwNFExQDd:L3G+
cells by alamar blue assay NXTzNoFwTnWwY4Tpc44h[XO|YYm= M4D0U2lEPTBiPTCwMlA1KM7:TR?= NFrLPYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEC3NFk3PSd-MUiwO|A6PjV:L3G+
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P388 MlHkR5l1d3SxeHnjbZR6KGG|c3H5 MV[3NkBp NXvtdmN6UUN3MDC9JFAvODFizszN NWLyVlBiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFg2PjZpPkG4N|A5PTZ4PD;hQi=>
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K562 NWDnPYpvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vDflczKGh? MoXiTWM2OCB;IECuNFAxPiEQvF2= NFjjUYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxN|MxPyd-MUizNVM{ODd:L3G+
KB3-1 NIGwZlVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnTrO|IhcA>? MnnVTWM2OCB;IECuNFAzKM7:TR?= Mn7JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MUOzNFcoRjF6M{GzN|A4RC:jPh?=
HepG2 NYHYWIZ[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGDueZY4OiCq MoO3TWM2OCB;IECuNFA4KM7:TR?= Mk\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MUOzNFcoRjF6M{GzN|A4RC:jPh?=
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A549 NX\pbVR[S3m2b4TvfIlkcXS7IHHzd4F6 NULseVBWOyCmYYnz NFL3O3BKSzVyIE2gNE4xODdizszN MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzOUG1OEc,OTh2MUmxOVQ9N2F-
MCF7 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NGDrU|Q{KGSjeYO= MoTPTWM2OCB;IECuNFEyPyEQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzOUG1OEc,OTh2MUmxOVQ9N2F-
HepG2 NEfnRZBEgXSxdH;4bYNqfHliYYPzZZk> Ml3EN{Bl[Xm| MVXJR|UxKD1iMD6wOFY5KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzOUG1OEc,OTh2MUmxOVQ9N2F-
MDA-MB-231 M4fZTGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXOzJIRigXN? MnnPTWM2OCB;IECuNFcxOyEQvF2= NX22elZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NVkyPTRpPkG4OFE6OTV2PD;hQi=>
Hep3B MUDDfZRwfG:6aXPpeJkh[XO|YYm= M1y1R|Mh\GG7cx?= NVr0S4dZUUN3MDC9JFAvOTNizszN NEPqcpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESxPVE2PCd-MUi0NVkyPTR:L3G+
CCRF-CEM MmjwR5l1d3SxeHnjbZR6KGG|c3H5 NUjBUYViPzJiaB?= MoPjTWM2OCB;IECuNFAyOjd2IN88US=> NHXvdos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES1NFQ2Pid-MUi0OVA1PTZ:L3G+
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MX1 M3z0d2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mmj2O|IhcA>? MYTJR|UxKD1iMD6wN|Uh|ryP M17MPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEWwOFU3Lz5zOES1NFQ2PjxxYU6=
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U2OS MkCzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MlvKOFghcA>? NEexVGJKSzVyIE2gNE4xOjRizszN NF7VRWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES2NVk6Pyd-MUi0OlE6QTd:L3G+
A2780 MVjDfZRwfG:6aXPpeJkh[XO|YYm= NUXPO4N1PzJiaB?= NFfKPIZKSzVyIE2gNE4xODF|ODFOwG0> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4NUi0Okc,OTh2NkW4OFY9N2F-
MCF7 MoTiR5l1d3SxeHnjbZR6KGG|c3H5 MY[3NkBp MY\JR|UxKD1iMD6wNFE4KM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4NUi0Okc,OTh2NkW4OFY9N2F-
LCC6 MkLMR5l1d3SxeHnjbZR6KGG|c3H5 NYfoPYxWPzJiaB?= M2LNVWlEPTBiPTCwMlAxOzFizszN NInzbZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES2OVg1Pid-MUi0OlU5PDZ:L3G+
1A9PTX22 MnnwR5l1d3SxeHnjbZR6KGG|c3H5 M3;FfFczKGh? MUfJR|UxKD1iMD6xOlA4KM7:TR?= NVPuc4FtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OlU5PDZpPkG4OFY2QDR4PD;hQi=>
NCI/ADR MYjDfZRwfG:6aXPpeJkh[XO|YYm= NITxfYM4OiCq M2O4[mlEPTBiPTCwMlMh|ryP NUXlNFJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OlU5PDZpPkG4OFY2QDR4PD;hQi=>
1A9PTX10 NYTGOpRuS3m2b4TvfIlkcXS7IHHzd4F6 NGPnfFA4OiCq M3rXNmlEPTBiPTCwMlU{Ojl3IN88US=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4NUi0Okc,OTh2NkW4OFY9N2F-
HT29 M3faXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M13DUWdKPTBiPTCwMlAyPSEQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDVyMk[zPUc,OTh3MEK2N|k9N2F-
M21 MlLzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4DVRmdKPTBiPTCwMlA{PyEQvF2= NUH4VFF7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1NFI3OzlpPkG4OVAzPjN7PD;hQi=>
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HepG2 NILsWFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfjSYN2PzJiaB?= MnTGTWM2OCB;IECuNFA2QSEQvF2= MkTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3MUK5PFQoRjF6NUGyPVg1RC:jPh?=
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KB403 NV[3ZpBQS3m2b4TvfIlkcXS7IHHzd4F6 MWSyOEBp NGW2[XRKSzVyIE2gNE4xODFizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV6NkS5NUc,OTh3OE[0PVE9N2F-
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MCF7 M2\P[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NGTQeIIzPCCq NV;afY9iUUN3MDC9JFAvODB4IN88US=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV6NkS5NUc,OTh3OE[0PVE9N2F-
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HCT116 NVP1bHFxS3m2b4TvfIlkcXS7IHHzd4F6 NU\GdGJMUUN3MDC9JFAvODF|NjFOwG0> M{jzZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkC2OVQxLz5zOE[wOlU1ODxxYU6=
SF268 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NFv4OJRKSzVyIE2gNE4xOTV|IN88US=> NF\3dVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[wOlU1OCd-MUi2NFY2PDB:L3G+
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MDA-MB-435 NHTq[FRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MlH6O|IhcA>? M1PzV2dKPTBiPTCwMlAxPCEQvF2= NHTMSVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[xNFk6PSd-MUi2NVA6QTV:L3G+
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HCT8 M4rNNmN6fG:2b4jpZ4l1gSCjc4PhfS=> NEfQUmpKSzVyIE2gN{4zQSEQvF2= NWW5VZpwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3NFEzQDFpPkG4O|AyOjhzPD;hQi=>
K562 NWTvVFZzS3m2b4TvfIlkcXS7IHHzd4F6 MYjJR|UxKD1iMz62OUDPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDdyMUK4NUc,OTh5MEGyPFE9N2F-
HepG2 NWO1W|VSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXj1c3ExPDhiaB?= MXnJR|UxKD1iMD62NkDPxE1? M3H2OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{CxN|AyLz5zOEewNVMxOTxxYU6=
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HCT116 M3rvXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NInYOIc1QCCq M4qzRWlEPTBiPTC2MlE5KM7:TR?= M{XpUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{CxN|AyLz5zOEewNVMxOTxxYU6=
A549 NUPx[m9MS3m2b4TvfIlkcXS7IHHzd4F6 NXTpWmk3UUN3MDC9JFAvODB{IN88US=> M3WyNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{G1O|gzLz5zOEexOVc5OjxxYU6=
CCRF-CEM M13CVmN6fG:2b4jpZ4l1gSCjc4PhfS=> MV23NkBp NH7SNZlKSzVyIE2gNE4xODFzIN88US=> MonlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh5NUK4OlkoRjF6N{WyPFY6RC:jPh?=
SKOV3 MoruRY51cWOjbnPldkBie3OjeR?= NYLLTmd7PzJiaB?= MV\JR|UxKD1iMD6wNFE{PCEQvF2= NGjV[o89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEe2NlM2QCd-MUi3OlI{PTh:L3G+
MCF7 MorGR5l1d3SxeHnjbZR6KGG|c3H5 NG\UeIJGTDVyIE2gNE4xODN{IN88US=> NX7UZVM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5NlY4ODFpPkG4PVI3PzBzPD;hQi=>
NCI/ADR-RES MnzLR5l1d3SxeHnjbZR6KGG|c3H5 NVjTU3diTUR3MDC9JFEvPSEQvF2= Mo\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7Mk[3NFEoRjF6OUK2O|AyRC:jPh?=
PANC1 NF;JS21EgXSxdH;4bYNqfHliYYPzZZk> MUS3NkBp NEm0ZpdKSzVyIE2gNE4xODl7IN88US=> MlLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7NUG3PFcoRjF6OUWxO|g4RC:jPh?=
DLD1 MX3DfZRwfG:6aXPpeJkh[XO|YYm= NELGfHk4OiCq M4LjNGlEPTBiPTCwMlAzOiEQvF2= M{TlUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUWxO|g4Lz5zOEm1NVc5PzxxYU6=
AsPC1 MWjDfZRwfG:6aXPpeJkh[XO|YYm= M3rmdlczKGh? MUTJR|UxKD1iMD6wPFkh|ryP NEPHUXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEm1NVc5Pyd-MUi5OVE4QDd:L3G+
NCI/ADR-RES MX7DfZRwfG:6aXPpeJkh[XO|YYm= M2TXbVczKGh? NVrN[oIxUUN3MDC9JFEvOyEQvF2= NXLZeoQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5OVE4QDdpPkG4PVUyPzh5PD;hQi=>
MCF7 NXj0SnZyS3m2b4TvfIlkcXS7IHHzd4F6 NH;QWItGTDVyIE2gNE4xODJzIN88US=> MoHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7N{e2OVkoRjF6OUe3OlU6RC:jPh?=
NCI/ADR-RES M4rIb2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoDtSWQ2OCB;IEKg{txO M4T2PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUe3OlU6Lz5zOEm3O|Y2QTxxYU6=
A431 NHO1eJREgXSxdH;4bYNqfHliYYPzZZk> MVu3NkBp M3XjOGlEPTBiPTCwMlAzPTFizszN MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl7MEW3OEc,OTh7OUC1O|Q9N2F-
MCF7 NH7Td3BEgXSxdH;4bYNqfHliYYPzZZk> MVu3NkBp NUTSTZlKUUN3MDC9JFAvODN7IN88US=> Mm\2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7OUC1O|QoRjF6OUmwOVc1RC:jPh?=
MDA-MB-231 Mm\pR5l1d3SxeHnjbZR6KGG|c3H5 MXK3NkBp NFu0dZJKSzVyIE2gNE4xPDdzIN88US=> M3fVPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUmwOVc1Lz5zOEm5NFU4PDxxYU6=
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PANC1 NX\aRVFPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1G2UVczKGh? MUXJR|UxKD1iMD6wNFk6KM7:TR?= NXfwcWlxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNlI3PzlpPkG5NFIzPjd7PD;hQi=>
DLD1 M{j1R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEjlOm84OiCq MYTJR|UxKD1iMD6wNlIh|ryP NHG5O449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCyNlY4QSd-MUmwNlI3Pzl:L3G+
AsPC1 MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGfVO484OiCq M1vRUWlEPTBiPTCwMlA5QSEQvF2= M{P5OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEKyOlc6Lz5zOUCyNlY4QTxxYU6=
NCI/ADR NYXweYdZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3TBOFczKGh? M3PkdWlEPTBiPTCxMlMh|ryP M4naflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEKyOlc6Lz5zOUCyNlY4QTxxYU6=
A2780 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYWyJIRigXN? MoG2TWM2OCB;IECuNFI{PCEQvF2= NHrvdFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCyPFExOid-MUmwNlgyODJ:L3G+
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COLO205 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWqyOEBp Mk\MTWM2OCB;IECuNFA{OyEQvF2= MnLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNEGyOFcoRjF7MESxNlQ4RC:jPh?=
KB 8.5 MmjZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NXW1RZRvOyCmYYnz M{TFbWlEPTBiPTCwMlAzPiEQvF2= NYr6eFFkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOFEzPDdpPkG5NFQyOjR5PD;hQi=>
KBV1 NGK1bYhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NUnzd4p6OyCmYYnz M{fMXWlEPTBiPTCyMlAyOyEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB2MUK0O{c,OTlyNEGyOFc9N2F-
KB NGjiVXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUK5[XhmPzJiaB?= M4r1OGlEPTBiPTCwMlAxOzNizszN NGDyXIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c4Oyd-MUmwOVM4PzN:L3G+
KB-7D NI\uW3FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mkj4O|IhcA>? MoHwTWM2OCB;IECuNFA4QSEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e3N{c,OTlyNUO3O|M9N2F-
Pgp170 overexpressing multidrug resistant-KB-TAX50 MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnUenE6PzJiaB?= MX;JR|UxKD1iMD6yO|Mh|ryP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e3N{c,OTlyNUO3O|M9N2F-
NPC-TW01 M{Xm[mN6fG:2b4jpZ4l1gSCjc4PhfS=> NWD1Wng{PzJiaB?= NXqyPJBTUUN3MDC9JFAvODB4IN88US=> M3rqU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEWzO|gyLz5zOUC1N|c5OTxxYU6=
MES-SA MXXDfZRwfG:6aXPpeJkh[XO|YYm= MVm3NkBp NIPnWZlKSzVyIE2gNE4xODhizszN MlnwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUO3PFEoRjF7MEWzO|gyRC:jPh?=
NCI-H838 MXrDfZRwfG:6aXPpeJkh[XO|YYm= Mk\mO|IhcA>? NYezc|RJUUN3MDC9JFAvODJ4IN88US=> NIC0NWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c5OSd-MUmwOVM4QDF:L3G+
HCT116 NUftfoVOS3m2b4TvfIlkcXS7IHHzd4F6 Mn\JO|IhcA>? MnOwTWM2OCB;IECuNFYyKM7:TR?= M1nmeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEWzO|gyLz5zOUC1N|c5OTxxYU6=
cells after 72 hrs by MTT assay MX;DfZRwfG:6aXPpeJkh[XO|YYm= M133dWlEPTBiPTC1MlE1KM7:TR?= MmLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUO3PFEoRjF7MEWzO|gyRC:jPh?=
Hep3B MWnDfZRwfG:6aXPpeJkh[XO|YYm= NGjmPW44OiCq M{\3cWlEPTBiPTC3MlI3KM7:TR?= M4HOPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEWzO|gyLz5zOUC1N|c5OTxxYU6=
A498 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NYjxUW5GPzJiaB?= NETt[ZZKSzVyIE2gPE45OSEQvF2= NILFflA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c5OSd-MUmwOVM4QDF:L3G+
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HCT116 NXnSZWVsS3m2b4TvfIlkcXS7IHHzd4F6 NIPFZ3Q4OiCq MoWwTWM2OCB;IECuNFAyOSEQvF2= NFH2e489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOFI2OCd-MUmxNlQzPTB:L3G+
CCRF-CEM NEjXfIpEgXSxdH;4bYNqfHliYYPzZZk> NULOZlhIPzJiaB?= M3zXdmlEPTBiPTCwMlAxOzFizszN Mk\SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMkSyOVAoRjF7MUK0NlUxRC:jPh?=
MX1 NXLWRXpIS3m2b4TvfIlkcXS7IHHzd4F6 MXi3NkBp MlHBTWM2OCB;IECuNFQ3KM7:TR?= NVLYSYRvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxNlQzPTBpPkG5NVI1OjVyPD;hQi=>
HCT116 MVjDfZRwfG:6aXPpeJkh[XO|YYm= M1i3N|Qh\GG7cx?= M{XjdmlEPTBiPTCwMlAxOTFizszN NUL0d2xURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxNlgyPTZpPkG5NVI5OTV4PD;hQi=>
HT-29 NWX6V2VxS3m2b4TvfIlkcXS7IHHzd4F6 NWi5WYpHPCCmYYnz M2ixW2lEPTBiPTCwMlAxOzZizszN NEDDOlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyPFE2Pid-MUmxNlgyPTZ:L3G+
A2780 M2fwTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFrlcZg1QCCq M4fFdGlEPTBiPTCwMlAxOTNizszN M{jzU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK4PVczLz5zOUGyPFk4OjxxYU6=
KB NIXoWlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkXwSWQ2OCB;IECuNFI{KM7:TR?= MmrqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzNkGzNVYoRjF7MU[xN|E3RC:jPh?=
HepG2 MXTDfZRwfG:6aXPpeJkh[XO|YYm= M2XVOmdKPTBiPTCwMlAxOSEQvF2= NGji[FA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG5OVkxOSd-MUmxPVU6ODF:L3G+
WI38 NHHReXdEgXSxdH;4bYNqfHliYYPzZZk> NGDSPGNIUTVyIE2gNE4xOTN5IN88US=> NHHIUFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG5OVkxOSd-MUmxPVU6ODF:L3G+
RKO MnnFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYnJR|UxKD1iMD6wNkDPxE1? M{[4OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKwNFE5Lz5zOUKyNFAyQDxxYU6=
KB/HeLa NYftO3BxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MU\JR|UxKD1iMD6wN{DPxE1? NGnsWVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNFAyQCd-MUmyNlAxOTh:L3G+
SKOV3 MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NHrjUGJKSzVyIE2gNE4xPSEQvF2= NVj0ZmEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
SF268 MnnMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGHQb|lKSzVyIE2gNE4xPSEQvF2= M4nPS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKwNFE5Lz5zOUKyNFAyQDxxYU6=
P388 NV;tOYtWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MnLaOFghcA>? MmL4TWM2OCB;IECuNFUh|ryP NUnKeplHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
cells ectopic expression of human NInpXZFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MX20PEBp MVHJR|UxKD1iMD6wOUDPxE1? NHf0RY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNFAyQCd-MUmyNlAxOTh:L3G+
L1210 NVPGPZg1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1HIcFQ5KGh? MXPJR|UxKD1iMD6wOkDPxE1? NXfVcZhTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
NCI-H460 Mo\wRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MkDpTWM2OCB;IECuNFch|ryP MoLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkCwNVgoRjF7MkKwNFE5RC:jPh?=
MkTpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2rWcVQ5KGh? MlfZTWM2OCB;IECuN{DPxE1? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
MCF7 NILaboxEgXSxdH;4bYNqfHliYYPzZZk> NVrDdodtPzJiaB?= MV3JR|UxKD1iMD6wNFEzKM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
A2780 MYPDfZRwfG:6aXPpeJkh[XO|YYm= MoHxO|IhcA>? NUX3WYxXUUN3MDC9JFAvODBzM{ig{txO MojiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
wild type A2780 NGW0Z4xEgXSxdH;4bYNqfHliYYPzZZk> NXzadnZNPzJiaB?= MmLuTWM2OCB;IECuNFAyPyEQvF2= M3TR[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkO5NlQxLz5zOUKzPVI1ODxxYU6=
cisplatin-resistant A2780 MonrR5l1d3SxeHnjbZR6KGG|c3H5 NH62eVk4OiCq NWPte3BRUUN3MDC9JFAvODB{MjFOwG0> MoLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
LCC-6 NIHSeopEgXSxdH;4bYNqfHliYYPzZZk> MoDFO|IhcA>? NWfzRpNUUUN3MDC9JFAvODB{NEWg{txO NYT6XHRTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
HT-29 MYnDfZRwfG:6aXPpeJkh[XO|YYm= NV23UHRmPzJiaB?= M1PESmlEPTBiPTCwMlAxOzZizszN NIPIPHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzPVI1OCd-MUmyN|kzPDB:L3G+
H460 M4L6eGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mm\6O|IhcA>? MXTJR|UxKD1iMD6wNFQ6KM7:TR?= MluwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
topotecan-resistant A2780 NFG5d4ZEgXSxdH;4bYNqfHliYYPzZZk> MmTJO|IhcA>? NG\EVHdKSzVyIE2gNE4xODd{IN88US=> NHTkZYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzPVI1OCd-MUmyN|kzPDB:L3G+
PANC1 NGDGUHlEgXSxdH;4bYNqfHliYYPzZZk> MVW3NkBp MXnJR|UxKD1iMD6wNlU4KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
1A9PTX22 M3O5dGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYHMdWU1PzJiaB?= MmSxTWM2OCB;IECuNVYxPyEQvF2= NX;QTmVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
NCI/ADR NH7QdHpEgXSxdH;4bYNqfHliYYPzZZk> Mn;qO|IhcA>? M1v6[2lEPTBiPTCwMlMh|ryP NF3KNI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzPVI1OCd-MUmyN|kzPDB:L3G+
A2780 Mni1SpVv[3Srb36gZZN{[Xl? M4PjcGlEPTBiPTCwMlM5PiEQvF2= MoXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
1A9PTX10 MVrDfZRwfG:6aXPpeJkh[XO|