GW4064

目录号:S2782

仅限科研使用

GW4064是一种farnesoid X receptor (FXR)激动剂,CV1细胞系中EC50为65 nM。浓度达到1 μM时,对其他核受体没有活性。GW4064在MCF-7细胞中可刺激自噬。

GW4064 Chemical Structure

CAS: 278779-30-9

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1219.39 现货
RMB 571.57 现货
RMB 2220.65 现货
大包装 有超大折扣
大剂量询单有大折扣!

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的GW4064发表文献21篇:

产品安全说明书

FXR抑制剂选择性比较

相关FXR产品

生物活性

产品描述 GW4064是一种farnesoid X receptor (FXR)激动剂,CV1细胞系中EC50为65 nM。浓度达到1 μM时,对其他核受体没有活性。GW4064在MCF-7细胞中可刺激自噬。
靶点
FXR [1]
(CV1)
65 nM(EC50)
体外研究

GW 4064是一种完全激动剂,在转染有鼠源和人源FXR表达载体以及确定的报告基因的CV-1细胞中, EC50分别为80和90。GW 4064直到1 μM浓度对其它核受体也没有活性,包括维甲酸受体。因此, GW 4064是一种强有效和选择性的非类固醇FXR激动剂[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NYjiXVFNTnWwY4Tpc44h[XO|YYm= NELXOlVC\2:waYP0bYMh[WO2aY\peJkh[XRiRmjSJIlvKEiHS{K5N{Bk\WyuczDifUBISUx2IITyZY5{[WO2aY\heIlwdiCjY4Tpeol1gSxiRVO1NEA:KDBwMEeg{txONg>? M{jx[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkmyOlExLz5zN{K5NlYyODxxYU6=
CV1 MWfGeY5kfGmxbjDhd5NigQ>? NIXHWmhC\2:waYP0JIFkfGm4aYT5JIF1KE[[UjDlfJBz\XO|ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliQ2[xJINmdGy|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIhfHKjboPp[Y51KHS{YX7z[oVkfGmxbjDhd5NigSxiRVO1NEA:KDBwME[1JO69VS5? M4j1VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkKxOVI{Lz5zOE[yNVUzOzxxYU6=
CV1 MY\GeY5kfGmxbjDhd5NigQ>? MWDB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIF\YVkB1emGwc3\lZ5Rm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEXjFiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKHS{YX7zbYVvfCC2cnHud4Zm[3Srb36gZZN{[XluIFXDOVAhRSByLkC2OUDPxE1w MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTRzMES2NEc,OTl2MUC0OlA9N2F-
CV1 NYnCTGpETnWwY4Tpc44h[XO|YYm= M4nIdmlv[3KnYYPlJIlvKGi3bXHuJGZZWi2vZXTpZZRm\CC2cnHud4lmdnRidILhcpNkemmydHnvckBw\iCudXPp[oVz[XOnIILldI9zfGW{IHflcoUhfHKjboPm[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhS1ZzIHPlcIx{NCCHQ{WwJF0hOC5yNkWg{txONg>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV6Nke2PUc,OTl3OE[3Olk9N2F-
HEK293 MkX6SpVv[3Srb36gZZN{[Xl? MVPB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIH\1cIwhdGWwZ4ToJGZZWiC2cnHud4Zm[3SnZDDpckBJTUt{OUOgZ4VtdHNiY3;lfJBz\XO|aX7nJJBVWmW6RHXzeE9xT0x{cILvcY91d3JiYYPz[ZN{\WRiYYOgcJVkcW[ncnHz[UBi[3Srdnn0fUBjgSCmaYLlZ5QhemWyb4L0[ZIh[2WubIXsZZIh[XO|YYmsJGVEPTBiPTCwMlA{KM7:TT6= NFLkXYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[zPFI4QCd-MkC2N|gzPzh:L3G+
HEK293 M2H2dmZ2dmO2aX;uJIF{e2G7 MWrB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFfTWE1nfXOnZDDGXHIhVEKGIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiY3;lfJBz\XO|aX7nJGdCVDRvRF7BJIJqdmSrZzDkc41icW5iYX7kJJBHWmy3YzDifUBu[W2vYXzpZY4hd26nLXj5ZpJq\CCjc4PhfUwhTUN3MDC9JFAvODN3IN88UU4> M{ntNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkO4Nlc5Lz5{ME[zPFI4QDxxYU6=
CV-1 MkDKSpVv[3Srb36gZZN{[Xl? M2XXcGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gSnhTKEyERDDp[ZhxemW|c3XkJIlvKG2xbnvlfUBEXi1zIHPlcIx{KGG|c3Xzd4VlKGG|IITyZY5{[WO2aY\heIlwdiCxZjDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViZYjwdoV{e2mxbjygSWM2OCB;IECuNFY2KM7:TT6= Ml;QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{NU[wNFUoRjJzMkW2NFA2RC:jPh?=
CV1 MXHGeY5kfGmxbjDhd5NigQ>? NHHqclJC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGZZWiCOQlSgeJJidnOoZXP0[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR3YyKGOnbHzzJIFnfGW{IH;2[ZJvcWeqdDDpcoN2[mG2aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IECuNFY2KM7:TT6= M1fGVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEmwN|U3Lz5{MUi5NFM2PjxxYU6=
HEK293 MVvGeY5kfGmxbjDhd5NigQ>? MoDDRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDy[YNwdWKrbnHueEBHYFJiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyClb3X4dJJme3OrbnegR21ZNUeDTETOJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IECuNFch|ryPLh?= NYjnZ|BmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1PFM3OTdpPkKyOVg{PjF5PD;hQi=>
HEK293 NFW3fo9HfW6ldHnvckBie3OjeR?= M2rF[2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gSnhTKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gNE4xOjZizszNMi=> NETZRXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVY5QCd-MkWzNFU3QDh:L3G+
CV1 NVPzN3B2TnWwY4Tpc44h[XO|YYm= MVXB[49vcXO2IHHjeIl3cXS7IHH0JGZZWiBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnueI8h[W[{aXPhckBoemWnbjDtc45s\XliQ2[xJINmdGy|IHHzd4V{e2WmIHHzJIxq\2GwZD3t[YRq[XSnZDD0doFve2O{aYD0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKvJJRz[W6|aXXueEB1emGwc3\lZ5Rqd25iYYPzZZktKEWFNUCgQUAxNjB4NTFOwG0v MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7OUi4N{c,OjV2OUm4PFM9N2F-
HeLa MX\GeY5kfGmxbjDhd5NigQ>? MkX5NlQhcHK| MYHB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIH\1cIwhdGWwZ4ToJGZZWiCneIDy[ZN{\WRiaX6gTIVN[SClZXzsd{Bkd3S{YX7z[oVkfGWmIIfpeIgheFOJNT3oeY1idiCUWGKgZYZ1\XJiMkSgbJJ{KGK7IFT1ZYwuT2yxIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvPTFizszNMi=> NF;JbGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFIzPyd-MkW5N|QzOjd:L3G+
HEK293 MV3GeY5kfGmxbjDhd5NigQ>? NVH6NXdqSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBHYFJidILhcpNn\WO2ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJJRz[W6|Y4LpdJRqd26jbDDhZ5Rqfmm2eTDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkO3N{DPxE1w Mm\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NkixOFQoRjJ4NU[4NVQ1RC:jPh?=
HEK-293 NXHZXZVHTnWwY4Tpc44h[XO|YYm= Ml3DRYdwdmm|dDDhZ5Rqfmm2eTDheEBENXSncn3pcoFtKEejbESteIFo\2WmIHj1cYFvKE[[UjCoNVg4KHSxIES3NkBz\XOrZIXld{kh\XiycnXzd4VlKGmwIFjFT{0zQTNiY3XscJMh[29vZYjwdoV{e2mwZzDwSnJtfWNiYomgcYFudWGuaXHuJI9v\SCqeXLybYQh[XO|YYmsJGVEPTBiPTCwMlA{PSEQvF2u M2nhOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Mk[4Olk3Lz5{N{K2PFY6PjxxYU6=
insect cells M4rnSWZ2dmO2aX;uJIF{e2G7 NVWzSpkxOSCqch?= M2[3dGFod26rc4SgZYN1cX[rdImgZZQhemWlb33ibY5idnRiaIXtZY4hT1OWLYTh[4dm\CCIWGKgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKChzOUOgeI8hPDd{IILld4llfWW|KTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiaX7z[YN1KGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDpcpRmemGldHnvckB4cXSqIHLpc5RqdiCuYXLlcIxm\CCVUlOtNUBi\nSncjCxJIhzKGK7IFjUVmYh[XO|YYmsJGVEPTBiPTCwMlAyQSEQvF2u M2\ib|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS4PFA3Lz5{OUG0PFgxPjxxYU6=
HEK293T M4H0fGZ2dmO2aX;uJIF{e2G7 MnPuNlQhcHK| MUHB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIF\YVkBmgHC{ZYPz[YQhcW5iSFXLNlk{XCClZXzsd{Bie3Onc4Pl[EBieyCEU1XQJJBzd22xdHXyJIRzcX[nbjDj[YxtfWyjcjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IECuNFk2KM7:TT6= M3;wPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS4PFA3Lz5{OUG0PFgxPjxxYU6=
HepG2 NUiwS3NtTnWwY4Tpc44h[XO|YYm= Mn62NUB2VQ>? MVuxPEBpenN? MX3E[YNz\WG|ZTDpckBEYVB5QUGg[4Vv\SCneIDy[ZN{cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDFidV2gZYZ1\XJiMUigbJJ{KGK7IGLUMXBEWg>? M17kZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OU[zN|cyLz5zN{m2N|M4OTxxYU6=
Caco-2 NIrTdJFHfW6ldHnvckBie3OjeR?= M2LweFEhfU1? NUmxfo8xPiCmYYnz NHzYUmRC[3SrdnH0bY9vKG:oIFnCRWJRKGenbnWg[ZhxemW|c3nvckBqdiCqdX3hckBE[WOxLUKgZ4VtdHNiYYSgNUB2VSCjZoTldkA3KGSjeYOgZpkhWlRvUFPS NIDEdYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2N|M4OSd-MUe5OlM{PzF:L3G+
HepG2 MYjGeY5kfGmxbjDhd5NigQ>? MnvhNUB2VQ>? MmfpNVghcHK| M2ThSmFkfGm4YYTpc44hd2ZiQmPFVEBo\W6nIHX4dJJme3Orb36gbY4hcHWvYX6gTIVxTzJiY3XscJMh[XRiMTD1UUBi\nSncjCxPEBpenNiYomgVnQuWEOU MmK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7NkOzO|EoRjF5OU[zN|cyRC:jPh?=
Huh7 M2Pme2Z2dmO2aX;uJIF{e2G7 M2LCVFEhfU1? MkXuNVghcHK| NIWzZ|NC[3SrdnH0bY9vKG:oIGPIVEBo\W6nIHX4dJJme3Orb36gbY4hcHWvYX6gTJVpPyClZXzsd{BifCBzIIXNJIFnfGW{IEG4JIhzeyCkeTDSWE1RS1J? M1m5N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OU[zN|cyLz5zN{m2N|M4OTxxYU6=
Huh7 M{\jXGZ2dmO2aX;uJIF{e2G7 MUCxJJVO Mlm2NVghcHK| NWC2dpJySWO2aY\heIlwdiCxZjDCV2VRKGenbnWg[ZhxemW|c3nvckBqdiCqdX3hckBJfWh5IHPlcIx{KGG2IEGgeW0h[W[2ZYKgNVghcHK|IHL5JHJVNVCFUh?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4M{O3NUc,OTd7NkOzO|E9N2F-
HepG2 NGTF[4hHfW6ldHnvckBie3OjeR?= NXfHe2R{OTBidV2= NIj3RldKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJHNJWCCvUl7BJIV5eHKnc4Ppc44hcW5ic3XyeY0ue3Sjco\l[EBpfW2jbjDI[ZBIOiClZXzsd{BifCBzMDD1UUBu\WG|dYLl[EBi\nSncjDveoVzdmmpaISgbY5kfWKjdHnvckBjgSCzUFPSJIFv[Wy7c3nz MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzN5Mki0NEc,Ojd|N{K4OFA9N2F-
HepG2 MljCSpVv[3Srb36gZZN{[Xl? M2r5bVExKHWP MU[xNEBucW6| MnXLTY5lfWO2aX;uJI9nKE[[Uj3t[YRq[XSnZDDBb5QueGixc4Doc5J6dGG2aX;uJIF1KFN2N{Ogd4l1\SCrbjDz[ZJ2dS2|dHHyeoVlKGi3bXHuJGhmeEd{IHPlcIx{KGG2IEGwJJVOKG2nYYP1doVlKGGodHXyJFExKG2rboOgZpkhf2W|dHXyckBjdG:2IHHuZYx6e2m| NIrqPIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{O3Nlg1OCd-MkezO|I5PDB:L3G+
HepG2 NHyzOG1HfW6ldHnvckBie3OjeR?= M4LpcVExKHWP MmTuNVAhdWmwcx?= NYDhZ5k3UW6mdXP0bY9vKG:oIF\YVk1u\WSrYYTl[EBCc3RvcHjvd5Bpd3K7bHH0bY9vKGmwIIPldpVuNXO2YYL2[YQhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gS3NMNTOkZYThMZBpd3OyaH;yfYxifGmxbjDheEAyOCC3TTDt[YF{fXKnZDDh[pRmeiBzMDDtbY5{KGK7IIfld5Rmem5iYnzveEBidmGueYPpdy=> M2XqRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5M{eyPFQxLz5{N{O3Nlg1ODxxYU6=
HepG2 NWLPc3RnTnWwY4Tpc44h[XO|YYm= MUixNEB2VQ>? M1vLOWFkfGm4YYTpc44hd2ZiRmjSJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCVSGCgcXJPSSCneIDy[ZN{cW:wIHH0JFExKHWPIHL5JHJVNVCFUjDt[ZRpd2R? MlPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByM{G2NVgoRjNyMEOxOlE5RC:jPh?=
HepG2 M4TBXGZ2dmO2aX;uJIF{e2G7 NFPHe5AyOCC3TR?= MWjBZ5RqfmG2aX;uJI9nKE[[UjDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YhTliUIH3SUmEh\XiycnXzd4lwdiCjdDCxNEB2VSCkeTDSWE1RS1JibXX0bI9l MlvCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByM{G2NVgoRjNyMEOxOlE5RC:jPh?=
HepG2 M1\iU2Z2dmO2aX;uJIF{e2G7 MoLTNVAhfU1? MlzkRYN1cX[jdHnvckBw\iCIWGKgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZH;3cpJm\3WuYYTpc44hd2ZiU2LFRnAuOWNibWLORUBmgHC{ZYPzbY9vKGG2IEGwJJVOKGK7IGLUMXBEWiCvZYToc4Q> M2m3U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEOxOlE5Lz5|MECzNVYyQDxxYU6=
3T3L1 MUXGeY5kfGmxbjDhd5NigQ>? NUjVWWRTOTBidV2= NWi3cG9HWmWmdXP0bY9vKGmwIHzpdIllKGGlY4XteYxifGmxbjDpckBud3W|ZTCzWFNNOSClZXzsd{BifCBzMDD1UUBjgSCRaXygVoVlKE9ic4ThbY5qdmdvYnHz[YQh[WK|b4LiZY5k\SCvZYToc4QhemWuYYTpeoUhfG9iY3;ueJJwdA>? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN2Mkm1O{c,OzB|NEK5OVc9N2F-
Assay
Methods Test Index PMID
Western blot PTEN / p-AKT / AKT p-EGFR / EGFR / p-ERK / ERK / p-Src / Src SOCS3 / p21 / p-STAT3 / STAT3 25187826 23119029 26416445
Growth inhibition assay Cell proliferation 25187826
体内研究 大鼠体内药代动力学实验显示GW 4064口服生物利用度为10%,t1/2 = 3.5小时。 Fisher大鼠按剂量填喂给药。7天之后, GW 4064处理的大鼠血清甘油三酯下降并具有剂量依赖特性,ED50 = 20 mg/kg[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:

[2]

  • Animal Models: Fisher大鼠
  • Dosages: 0-100 mg/kg
  • Administration: 口服, 一天两次

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
0.5% methylcellulose

11 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 542.84
化学式

C28H22Cl3NO4

CAS号 278779-30-9
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

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