(+)-JQ1

目录号:S7110

(+)-JQ1 Chemical Structure

Molecular Weight(MW): 456.99

(+)-JQ1是一种BET bromodomain抑制剂,作用于BRD4(1/2),无细胞试验中IC50为77 nM/33 nM,结合到BET家族的所有溴结构域,而不结合到BET家族以外的溴结构域。

规格 价格 库存 购买数量  
RMB 2227.39 现货
RMB 4667.45 现货
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客户使用该产品的9个实验数据:

  • The BET protein inhibitor JQ1 reduces c-Myc expression and attenuates primary MCC cell proliferation. A, decreased c-Myc expression in MCC-3 and MCC-5 treated with JQ1 (800 nmol/L) for 72 hours by qRT-PCR and immunoblotting. The mRNA expression of target genes was normalized to that of MRPS2 and a value of 1.0 was assigned to the mRNA expression of target genes in the control group (means+SEM; **, P < 0.01 vs. control); b-actin was used as a loading control for immunoblotting.

    Cancer Res 2014 74(23), 7090-102. (+)-JQ1 purchased from Selleck.

    Immunohistochemical staining of xenograft tumor tissues. Immunohistochemical staining of xenograft tumor tissues with the indicated antibodies. p21-, p27-, p57-, and Ki67 positive cells (brown staining) were quantified at x400 magnification (meansSEM;**, P < 0.01;***, P < 0.001 vs. control); scale bars, 10 um.

    Cancer Res 2014 74(23), 7090-102. (+)-JQ1 purchased from Selleck.

  • (D) Effect of JQ1 on alterations of actin cytoskeleton in VEGF-induced HUVECs. The cells were pretreated with DMSO or JQ1 (100 nM) for 6 h, and stimulated with VEGF (10 ng/mL) for 12 h. F-actin (red) and nuclei (blue) were stained with phalloidin and DAPI, respectively. Representative images from 3 independent experiments.

    Sci Rep, 2016, 6:23770.. (+)-JQ1 purchased from Selleck.

    Sensitivity of BEZ235-resistant cells to JQ-1 using the MTT assay.

    Oncotarget, 2016, 6(7):5134-46.. (+)-JQ1 purchased from Selleck.

  • B. Repressed MCC-3 xenograft tumor growth upon combined treatment with MLN0128 and JQ1. Tumor bearing mice were treated with MLN0128 or vehicle at 1 mg/kg/day by oral gavage and JQ1 or vehicle at 50 mg/kg/day by i.p. injection for a period of 30 days. C. A more effective reduction of MCC-3 xenograft tumor growth in the group treated with combined therapy. Fold-reduction of tumor growth was calculated as average tumor growth of control group divided by average tumor growth of treatment group. Tumor growth was calculated as final average tumor volume minus initial average tumor volume in each group.

    Oncotarget, 2016, 7(6):6576-92.. (+)-JQ1 purchased from Selleck.

    Int J Stem Cells, 2018, 11(1):131-140. (+)-JQ1 purchased from Selleck.

  • JQ1 induces cell cycle arrest and apoptosis in Cal27 cells. (C) Cal27 cells were treated with JQ1 for 24 h and whole cell lysates were tested by western blot assays for the expression of cleaved-caspase-3. GAPDH was used as a loading control. (D) Apoptosis of Cal27 cells treated with JQ1 at 0 and 0.5 µM JQ1; *P<0.05 vs. control (the DMSO group)

    Oncol Rep, 2016, 36(4):1989-96.. (+)-JQ1 purchased from Selleck.

    immunofluorescence staining of BRD4 in ACC-LM and ACC-83 cells treated with JQ1 at the concentration of 1 µM for 24 h (×200).

    Biol Res, 2017, 50(1):19. (+)-JQ1 purchased from Selleck.

  • Effect of BET domain family inhibition on AMI damage in cardiomyocytes. (A) LDH and (B) CK-MB activity in the serum. #P<0.01 vs. sham group; @P<0.05 and &P<0.01 vs. AMI group. BET, bromodomain and extra-terminal; AMI, acute myocardial infarction; LDH, lactate dehydrogenase; CK-MB, creatine kinase MB isoenzyme.

    Exp Ther Med, 2015, 10(6):2319-2324.. (+)-JQ1 purchased from Selleck.

产品安全说明书

Epigenetic Reader Domain抑制剂选择性比较

生物活性

产品描述 (+)-JQ1是一种BET bromodomain抑制剂,作用于BRD4(1/2),无细胞试验中IC50为77 nM/33 nM,结合到BET家族的所有溴结构域,而不结合到BET家族以外的溴结构域。
特性 (+)-JQ1比(-)-JQ1更有效。
靶点
BRD4 (2) [1]
(Cell-free assay)
BRD4 (1) [1]
(Cell-free assay)
33 nM 77 nM
体外研究

(+)-JQ1对映体直接结合到BET bromodomain结构域的Kac结合位点。(+)-JQ1(500 nM)与染色质竞争性结合到BRD4,导致NMC细胞分化和生长停滞。通过Ki67染色减少,证明了(+)-JQ1(500 nM)减弱NMC 797和Per403细胞系的快速增殖。(+)-JQ1(500 nM)作用于NMC 797细胞,有效降低BRD4靶基因的表达。(+)-JQ1作用于NMC 11060细胞,抑制细胞活力, IC50为4 nM。[1](+)-JQ1作用于MM细胞系,强抑制MYC表达。(+)-JQ1抑制KMS-34和LR5增殖,IC50分别为 68 nM和98 nM。(+)-JQ1(500 nM)处理MM.1S细胞,导致S期细胞比例明显下降,随之细胞停滞在G0/G1期增多。(+)-JQ1(500 nM)通过β-半乳糖苷酶染色,导致明显的细胞衰老。(+)-JQ1(800 nM)处理CD138+病患衍生的MM样本,显著降低细胞活力。[2] (+)-JQ1抑制LP-1细胞生长,GI50 为98 nM。(+)-JQ1(625 nM)导致LP-1细胞在G0/G1期的百分数增高。(+)-JQ1(500 nM)作用于LP-1细胞,抑制MYC, BRD4 和CDK9表达。[3](+)-JQ1(1 μM)处理潜伏感染的Jurkat T细胞,激活HIV转录。(+)-JQ1(50 μM)作用于Jurkat和HeLa细胞,主要刺激Tat依赖性的HIV转录。(+)-JQ1(5 μM)作用于J-Lat A2细胞,诱导Brd4解离,从而使Tat招募SEC到HIV启动子上,诱导Pol II CTD磷酸化和病毒转录。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K1  NFP5V|dE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYO0fYJjOjVyL{WwNE8yODByIH7N Ml\YNlQwPDhxN{KgbC=> NYrqSY5mTE2VTx?= NWLDcG1ZcW6qaXLpeJMh[2WubDD2bYFjcWyrdImgbY4h[m:2aDDkc5NmNSCjbnSgeIlu\S1iZHXw[Y5l\W62IH3hco5meg>? MYiyOlcxPzh6MR?=
BCPAP NYDuemlsS2WubDDWbYFjcWyrdImgRZN{[Xl? M3fwVVI2OC93MECvNVAxOCCwTR?= MVmyOE81QC95MjDo NXjoTng3TE2VTx?= MX\pcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDic5RpKGSxc3WtJIFv\CC2aX3lMUBl\XCnbnTlcpQhdWGwbnXy NVqyVoNPOjZ5MEe4PFE>
K1  MkDnR4VtdCCFeXPs[UBCe3OjeR?= MlfLNlUxNzVyMD:xNFAxKG6P NULjOYs{PzJiaB?= NY\6UmZRTE2VTx?= M1HudYFzemW|dIOgZ4VtdCCleXPs[UBifCCJMD;HNUBxcGG|ZR?= NVLsdIVbOjZ5MEe4PFE>
BCPAP NGCySIxE\WyuIFP5Z4xmKEG|c3H5 MUKyOVAwPTByL{GwNFAhdk1? MW[3NkBp NVW4SlBbTE2VTx?= MmDRZZJz\XO2czDj[YxtKGO7Y3zlJIF1KEdyL1exJJBp[XOn MYiyOlcxPzh6MR?=
Hep3B M3LPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonUNE0yOCEQvF2= MkGxOUBl NHH3V2RFVVOR MUXJR|UxRTBwMEig{txO NYPOOlhKOjZ3N{WxOlc>
HCCLM3 NUnnVph5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXGwMVExKM7:TR?= NXLJNmdjPSCm NVnZTZZOTE2VTx?= MkL6TWM2OD1yLkG0JO69VQ>? NGHlNHQzPjV5NUG2Oy=>
HuH7 M2HhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfMcot[OC1zMDFOwG0> MoXFOUBl M1;tdGROW09? M4\GUGlEPTB;MD6yNUDPxE1? MW[yOlU4PTF4Nx?=
HepG2 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fw[FAuOTBizszN MkmyOUBl MkHySG1UVw>? NUm4fmN4UUN3ME2wMlM1KM7:TR?= NHfRXpozPjV5NUG2Oy=>
SMMC7721 NVLmVpdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDnTokxNTFyIN88US=> MmPqOUBl NVLhT|Y6TE2VTx?= NHq2cohKSzVyPUCuOFEh|ryP NXrJ[m9EOjZ3N{WxOlc>
BEL7402 NUHGNWZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r1ZVAuOTBizszN M321[FUh\A>? MoqzSG1UVw>? M3Po[mlEPTB;MD60O{DPxE1? MmLoNlY2PzVzNke=
MHCC97H M3vGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq0TmExNTFyIN88US=> M4TNNVUh\A>? NHvVPWVFVVOR Mlv5TWM2OD1yLkSxJO69VQ>? MV:yOlU4PTF4Nx?=
Hep3B M4HBSGNmdGxiQ4njcIUhSXO|YYm= NVr5S2lmOC5zL{CuOU8zNjVizszN MmTEOFghcA>? M4CyUGROW09? NWLtemFndGWjZIOgeI8h[SC|dXLzeIFvfGmjbDDhZ4N2dXWuYYTpc44hd2ZiSFPDJINmdGy|IHnuJJN2[i2JMTDwbIF{\cLi MkHTNlY2PzVzNke=
HCCLM3 MVHD[YxtKEO7Y3zlJGF{e2G7 M33RVFAvOS9yLkWvNk42KM7:TR?= MmDuOFghcA>? Ml:4SG1UVw>? MoO5cIVi\HNidH:gZUB{fWK|dHHueIlidCCjY3P1cZVt[XSrb36gc4YhUEOFIHPlcIx{KGmwIIP1Zk1IOSCyaHHz[eKh MmLTNlY2PzVzNke=
Hep3B Mmr0RZBweHSxc3nzJGF{e2G7 Mk[0NE4yNzBwNT:yMlUh|ryP NWm1fZBsPDhiaB?= M3LPdGROW09? MlPhZYN1cX[jdHXzJINie3Cjc3WtN{BidmRiY3HzdIF{\S17IHX4dJJme3Orb36gZY5lKGmwZIXj[YQhWEGUUDDjcIVifmGpZTDhd{B4\WyuIHHzJIN6fG:laILvcYUh[yC{ZXzlZZNmKGmwdH:geIhmKGO7dH;wcIF{dSCocn;tJI1qfG:laH;u[JJq[Q>? MmDwNlY2PzVzNke=
HCCLM3 NFLienBCeG:ydH;zbZMhSXO|YYm= MnXNNE4yNzBwNT:yMlUh|ryP M3;udFQ5KGh? NEDpdoVFVVOR NECxN3pi[3SrdnH0[ZMh[2G|cHHz[U0{KGGwZDDjZZNx[XOnLUmg[ZhxemW|c3nvckBidmRiaX7keYNm\CCSQWLQJINt\WG4YXflJIF{KHenbHygZZMh[3m2b3Podo9u\SClIILlcIVie2ViaX70c{B1cGViY4n0c5Bt[XOvIH\yc40hdWm2b3Poc45lemmj NX\tcXJrOjZ3N{WxOlc>
A549 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU[wMlEuOTBizszN NYW4WZNPPzJiaB?= MVjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NH;xN|QzPjRzNUKyOS=>
H157 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjSbJMxNjFvMUCg{txO NYjNNHM4PzJiaB?= MWTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M{T0NVI3PDF3MkK1
H1299 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLTdnMxNjFvMUCg{txO MVS3NkBp NHLPTWZqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? M1nxblI3PDF3MkK1
A549 M3;NRmZ2dmO2aX;uJGF{e2G7 MX:xM|IvPS93IN88US=> MYGxNkBp NFTMOILDqHenYXvsfUBl\WO{ZXHz[YQhSmOuLUKgcIV3\Wy| NX22PFVjOjZ2MUWyNlU>
H1299 MoPVSpVv[3Srb36gRZN{[Xl? NXrJdFE1OS9{LkWvOUDPxE1? M1LkfVEzKGh? M4POdeKhf2Wja3z5JIRm[3KnYYPl[EBD[2xvMjDs[ZZmdHN? NI[3cnQzPjRzNUKyOS=>
H157 Mly4SpVv[3Srb36gRZN{[Xl? M1nET|EwOi53L{Wg{txO M4rzRlEzKGh? NHnpOpVl\WO{ZXHz[YQhTFJ2IHX4dJJme3Orb36= MVyyOlQyPTJ{NR?=
H1299 MmrTSpVv[3Srb36gRZN{[Xl? NILsN3YyNzJwNT:1JO69VQ>? MYmxNkBp MWfk[YNz\WG|ZXSgSHI1KGW6cILld5Nqd25? M1m0clI3PDF3MkK1
C8161 M1\iNmNmdGxiVnnhZoltcXS7IFHzd4F6 MV2wMVIh|ryP NEf6dWU1KGR? NGfL[4JFVVOR MnrO[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NEDycm8zPjN7N{KyNy=>
Mel285 NWfiPYZRS2WubDDWbYFjcWyrdImgRZN{[Xl? MoHTNE0zKM7:TR?= NGrMe|M1KGR? MV\EUXNQ M{PrZYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NFT3b2szPjN7N{KyNy=>
Mel290 NYDvSlFrS2WubDDWbYFjcWyrdImgRZN{[Xl? M1HKbVAuOiEQvF2= M3i0Z|Qh\A>? M4PFSGROW09? MWDk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NX3Jc3M2OjZ|OUeyNlM>
92.1 NV21TGR3S2WubDDWbYFjcWyrdImgRZN{[Xl? M4D6[lAuOiEQvF2= MlvCOEBl M{HyUGROW09? NWrYW3Y2\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MlvzNlY{QTd{MkO=
Omm1.3 MXXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NH\mUJUxNTJizszN M4rMNlQh\A>? M1TDc2ROW09? MnTr[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ M3\HW|I3Ozl5MkKz
Mel202 MX\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NFXxNmQxNTJizszN NHjY[FA1KGR? MXvEUXNQ NXvoN4dV\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NUHoZ3lROjZ|OUeyNlM>
Mel270 NXewbFdNS2WubDDWbYFjcWyrdImgRZN{[Xl? NUH6d|RLOC1{IN88US=> NIHyeZc1KGR? M{[wZmROW09? MVPk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MUSyOlM6PzJ{Mx?=
Omm1 NYLqcYxGS2WubDDWbYFjcWyrdImgRZN{[Xl? NWT3NY1VOC1{IN88US=> MmHNOEBl MWXEUXNQ M{DHZoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= MWCyOlM6PzJ{Mx?=
92.1 NGDSXXpCeG:ydH;zbZMhSXO|YYm= M1HMelUxOCCwTR?= M{TZTFQ5KGh? MXrEUXNQ MoLBbY5lfWOnczDhdI9xfG:|aYO= MUGyOlM6PzJ{Mx?=
Omm1.3 NF;SVnpCeG:ydH;zbZMhSXO|YYm= NH\6R5E2ODBibl2= M3\2ZlQ5KGh? NHe2XlVFVVOR M1rFVYlv\HWlZYOgZZBweHSxc3nz MWmyOlM6PzJ{Mx?=
92.1 Mnv4R4VtdCCFeXPs[UBCe3OjeR?= NW\BbldvPTByIH7N NWPUeXFCOjRxNEivO|IhcA>? NY[3ZodVTE2VTx?= M17JU4lv\HWlZYOgeIhmKGOnbHygZYNkfW23bHH0bY9vKGG2IIP1Zk1IOcLi NHvhfJEzPjN7N{KyNy=>
Omm1.3 M3rmRmNmdGxiQ4njcIUhSXO|YYm= MWO1NFAhdk1? MnjxNlQwPDhxN{KgbC=> MnzlSG1UVw>? NVWxPGhlcW6mdXPld{B1cGViY3XscEBi[2O3bYXsZZRqd25iYYSgd5VjNUdzwrC= NYT3NZd6OjZ|OUeyNlM>
A549 NXG4bXJpTnWwY4Tpc44hSXO|YYm= NUnhTlRuOTByL{SwNE8yODByIH7N M2\ZO|I1KGh? NYHpRnE6fXC{ZXf1cIF1\XNiYX7kJIFkfGm4YYTld{BUUVKWMR?= M3WzdlI3OjF{MUm5
MCF-7 M2mwbWZ2dmO2aX;uJGF{e2G7 Mo\mNVAxNzRyMD:xNFAxKG6P NF;rTWQzPCCq NEDTOYp2eHKnZ4XsZZRmeyCjbnSgZYN1cX[jdHXzJHNKWlRz NIfPTFkzPjJzMkG5PS=>
HEK293 Mn7jSpVv[3Srb36gRZN{[Xl? MXSxNFAwPDByL{GwNFAhdk1? MoPPNlQhcA>? MWr1dJJm\3WuYYTld{BidmRiYXP0bZZifGW|IGPJVnQy NHXySpgzPjJzMkG5PS=>
858 MYrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MUmwMVEh|ryP MYe1JIQ> NXL3V41iTE2VTx?= M4\0bYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M371RVI3OjB4M{Oz
DDR2L63V NHPZcI1E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NHT1UnIxNTFizszN MlKwOUBl M4fpc2ROW09? MlzV[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NWK3dIRUOjZ{ME[zN|M>
BE(2)-C NGnNVXNE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3fN[FEh|ryP NXHrUFZvOS12IHS= MW\k[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHlic3nncolncWOjboTsfS=> NHyyVoszPjB4N{S2OC=>
IMR-32 NXrJeWJSS2WubDDWbYFjcWyrdImgRZN{[Xl? NYPGeZBJOSEQvF2= NG\XVngyNTRiZB?= NWrOSHNv\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJNq\26rZnnjZY51dHl? MVmyOlA3PzR4NB?=
JF MYfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MnHJNUDPxE1? NEnHRVAyNTRiZB?= MWTk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHlic3nncolncWOjboTsfS=> NUW4elk1OjZyNke0OlQ>
BE(2)-M17 NWnhbZhMS2WubDDWbYFjcWyrdImgRZN{[Xl? M{nRdlEh|ryP NHzXN3oyNTRiZB?= NIL5eoNl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgd4lodmmoaXPhcpRtgQ>? MlW5NlYxPjd2NkS=
SK-N-SH Ml\zR4VtdCCYaXHibYxqfHliQYPzZZk> MkP6NUDPxE1? M4H1TVEuPCCm NV3hVJlL\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJNq\26rZnnjZY51dHl? NFfNN2gzPjB4N{S2OC=>
SK-N-DZ  NHvpdWdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MoDuNUDPxE1? M3XHb|EuPCCm NUXYXmtT\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJNq\26rZnnjZY51dHl? M1nGclI3ODZ5NE[0
HMC-1.1  NHnLVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUG1MVUxODBibl2= M3PyV|Q5KGh? MoDNSG1UVw>? NFXTTWVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NHP2b3kzPjB3NUOwNy=>
HMC-1.2 M4fIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXCPFg2NTVyMECgcm0> NGjHeVU1QCCq Mne2SG1UVw>? MW\pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MUKyOlA2PTNyMx?=
ROSA KIT WT  MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fZSVUuPTByMDDuUS=> MV[0PEBp MlTQSG1UVw>? MmPrbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M2HtPFI3ODV3M{Cz
ROSA KIT D816V Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\ZXJE2NTVyMECgcm0> NF7t[HE1QCCq NI\0fGtFVVOR NGP5N4dqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? M1LB[|I3ODV3M{Cz
HMC-1.1  NWDGcWxYSXCxcITvd4l{KEG|c3H5 MV:yNFAuPTByMDDuUS=> NWjaSGJSPDhiaB?= MmPQSG1UVw>? NHn0VGlqdmS3Y3XzJINmdGxiYYDvdJRwe2m|IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MlvYNlYxPTV|MEO=
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ROSA KIT WT  NXi3[nlHSXCxcITvd4l{KEG|c3H5 MkLLNlAxNTVyMECgcm0> NFHlVnc1QCCq NFG2bnJFVVOR MX3pcoR2[2W|IHPlcIwh[XCxcITvd4l{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NFvaeo0zPjB3NUOwNy=>
ROSA KIT D816V Mn3zRZBweHSxc3nzJGF{e2G7 NV22[2hnOjByLUWwNFAhdk1? NUnPPGc6PDhiaB?= MlTGSG1UVw>? M4TQXYlv\HWlZYOgZ4VtdCCjcH;weI9{cXNiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NFP1UGgzPjB3NUOwNy=>
494H NX;Me3YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULPeIhUPzJiaB?= Mnj2SG1UVw>? M1zvXmlEPTB;MD6xNlLDuTBwMEC0JO69VQ>? Mkm1NlU6PDR3Nk[=
493H MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrBWWZiPzJiaB?= Mmf4SG1UVw>? MoG0TWM2OD1yLkC0O:KyOC5yMEmg{txO NGrqUHIzPTl2NEW2Oi=>
716H MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPxTWZsPzJiaB?= MVrEUXNQ NVHq[JdnUUN3ME2wMlIyOsLzMD6wN|Qh|ryP Mo\rNlU6PDR3Nk[=
148I NFPKZlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfQXXcyPzJiaB?= M4TzVGROW09? NGX0W3dKSzVyPUCuNlg1yrFyLkCzOUDPxE1? NYnWT|BiOjV7NES1OlY>
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493L Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y4dFczKGh? NVHKeGUyTE2VTx?= M1\3NWlEPTB;MD6wOVDDuTBwMEGxJO69VQ>? Mmj2NlU6PDR3Nk[=
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494H MWXBdI9xfG:|aYOgRZN{[Xl? NXTa[3NPOC5{NT:wMlUwOS5yIN88US=> MWKyOEBp Ml\pSG1UVw>? M2TkXolv[3KnYYPld{Bt\X[nbIOgc4Yh[2ynYY\l[EBk[XOyYYPlMVPDqA>? NF7PT3czPTl2NEW2Oi=>
148I MmniRZBweHSxc3nzJGF{e2G7 MX[wMlI2NzBwNT:xMlAh|ryP M2LnZVI1KGh? MXzEUXNQ NVrwcIhrcW6lcnXhd4V{KGyndnXsd{Bw\iClbHXheoVlKGOjc4Dhd4UuO8Li M3[2UFI2QTR2NU[2
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MOLM13 MkH3SpVv[3Srb36gRZN{[Xl? MXiyOVAhdk1? MXWyOEBp MlL5SG1UVw>? MnPX[Y5p[W6lZYOgdZVqgmG{dHnubYIucW6mdXPl[EBud3KnIICyNUwhSkmPLDDhcoQh[2ynYY\l[EBRSVKS MW[yOVA2Ozh{NR?=
MV4-11  NHf1WWJHfW6ldHnvckBCe3OjeR?= NFfFdWszPTBibl2= NHjWbXYzPCCq MmT4SG1UVw>? MXrlcohidmOnczDxeYl7[XK2aX7pZk1qdmS3Y3XkJI1wemVicEKxMEBDUU1uIHHu[EBkdGWjdnXkJHBCWlB? NWCyT3VjOjVyNUO4NlU>
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MV4-11  NX34dYo3SXCxcITvd4l{KEG|c3H5 M2qyOlI2OCCwTR?= NVL0V4drPDhiaB?= Ml3vSG1UVw>? MmjZbY5lfWOnczDzbYdvcW[rY3HueIx6KGGyb4D0c5NqeyClb4Ty[YF1dWWwdDD3bZRpKHCxbnH0bY5q[g>? NVjDc|JTOjVyNUO4NlU>
Hela M2HrbmNmdGxiVnnhZoltcXS7IFHzd4F6 MmTCNE02ODBibl2= Ml3UO|IhcA>? NUjab2U{TE2VTx?= MV7k[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MnvsNlUxODl{OUW=
HBL-1 MWjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MkHLNE02ODBibl2= Mn3NO|IhcA>? MUTEUXNQ MYTk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NHKxOoEzPTByOUK5OS=>
HLY-1 M365eWNmdGxiVnnhZoltcXS7IFHzd4F6 M3zwOlAuPTByIH7N NEizNlM4OiCq MnLLSG1UVw>? M4OxdoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NGjnU2wzPTByOUK5OS=>
OCI-Ly3 MUDD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1rwNVAuPTByIH7N NW\6fFRSPzJiaB?= Mn7MSG1UVw>? MX;k[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NVHFT4l1OjVyMEmyPVU>
OCI-Ly10 NWrTXXlES2WubDDWbYFjcWyrdImgRZN{[Xl? M4TWNlAuPTByIH7N MWO3NkBp MkDtSG1UVw>? MoX5[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NIXoW4EzPTByOUK5OS=>
SU-DHL-4 Mn3MR4VtdCCYaXHibYxqfHliQYPzZZk> MkXxNE02ODBibl2= MWW3NkBp MULEUXNQ M3zXdoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= MlTsNlUxODl{OUW=
SU-DHL-5 M3qwUWNmdGxiVnnhZoltcXS7IFHzd4F6 NH3HPFYxNTVyMDDuUS=> MnKyO|IhcA>? MWfEUXNQ NIfCV2Rl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NYe1WHdqOjVyMEmyPVU>
SU-DHL-6 NUj0NI9tS2WubDDWbYFjcWyrdImgRZN{[Xl? M3[0PFAuPTByIH7N NHn2XpM4OiCq MlTsSG1UVw>? M2O4c4Rm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NF;ib2UzPTByOUK5OS=>
SU-DHL-10 NVm0OXRIS2WubDDWbYFjcWyrdImgRZN{[Xl? MUGwMVUxOCCwTR?= NIDnU3E4OiCq M2e2TmROW09? MVLk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? M3r0eFI2ODB7Mkm1
RC-K8 M4K2fWNmdGxiVnnhZoltcXS7IFHzd4F6 MoHkNE02ODBibl2= M3PQWlczKGh? MkTXSG1UVw>? M37wfIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NIe5bYgzPTByOUK5OS=>
OCI-Ly8 M1nT[WNmdGxiVnnhZoltcXS7IFHzd4F6 MUSwMVUxOCCwTR?= MU[3NkBp MkTQSG1UVw>? MXrk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? M3\qRVI2ODB7Mkm1
OCL-Ly18 M3HQdWNmdGxiVnnhZoltcXS7IFHzd4F6 M3\oXlAuPTByIH7N M17zWVczKGh? MmDqSG1UVw>? NYXVcGFW\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy Ml;DNlUxODl{OUW=
OCI-Ly3 M1v2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvJUXAyPzJxMkWwM|UxOCCwTR?= MnXwNk84KGR? NXTme5V4TE2VTx?= NUixVYxqcW6mdXPld{Bk\WyuLXP5Z4xmKGG{cnXzeEBifCC|dXKtS|Ehf2m2aDDtbY5qdWGuIHPlcIwh\GWjdHlCpC=> NF3BO|czPTByOUK5OS=>
OCI-Ly8 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXlS4FNOTd{L{K1NE82ODBibl2= NYjWVY5ROi95IHS= NUPUT3hxTE2VTx?= NF\GOHVqdmS3Y3XzJINmdGxvY4njcIUh[XK{ZYP0JIF1KHO3Yj3HNUB4cXSqIH3pcolu[WxiY3XscEBl\WG2aNMg NF33NYIzPTByOUK5OS=>
SU-DHL-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqxO|IwOjVyL{WwNEBvVQ>? NIjuTVQzNzdiZB?= NWTreVl1TE2VTx?= NUT1NHNEcW6mdXPld{Bk\WyuLXP5Z4xmKGG{cnXzeEBifCC|dXKtS|Ehf2m2aDDtbY5qdWGuIHPlcIwh\GWjdHlCpC=> NH\JNYczPTByOUK5OS=>
SU-DHL-10 NXzERXNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2xO|IwOjVyL{WwNEBvVQ>? NHOyZnkzNzdiZB?= NHq4fWRFVVOR MYDpcoR2[2W|IHPlcIwu[3mlbHWgZZJz\XO2IHH0JJN2[i2JMTD3bZRpKG2rbnntZYwh[2WubDDk[YF1cMLi M4XZZlI2ODB7Mkm1
OCI-Ly3 MmnsRZBweHSxc3nzJGF{e2G7 M2rUOVE4Oi9{NUCgcm0> NH3zSIE4\A>? NHvvO4FFVVOR MWrpcoNz\WG|ZYOgZ4F{eGG|ZT2zM|ch[WO2aY\peJnDqHOrZ37p[olk[W62bIm= NFS0clUzPTByOUK5OS=>
OCI-Ly8 MXrBdI9xfG:|aYOgRZN{[Xl? Mni5NVczNzJ3MDDuUS=> NF\4SJo4\A>? NIL4eJhFVVOR NULycZZNcW6lcnXhd4V{KGOjc4Dhd4UuOy95IHHjeIl3cXS7wrDzbYdvcW[rY3HueIx6 NEfGNnUzPTByOUK5OS=>
SU-DHL-4 NYroWW5xSXCxcITvd4l{KEG|c3H5 M1jmUVE4Oi9{NUCgcm0> NEPB[Yo4\A>? NIXVSIpFVVOR MlWwbY5kemWjc3XzJINie3Cjc3WtN{84KGGldHn2bZR6yqC|aXfubYZq[2GwdHz5 NUjKfZRCOjVyMEmyPVU>
SU-DHL-10 MkTHRZBweHSxc3nzJGF{e2G7 NXq4V2tzOTd{L{K1NEBvVQ>? M3rxR|dl NHLvdXZFVVOR NELOdZpqdmO{ZXHz[ZMh[2G|cHHz[U0{NzdiYXP0bZZqfHoEoIPp[45q\mmlYX70cJk> NFTveWIzPTByOUK5OS=>

... Click to View More Cell Line Experimental Data

体内研究 (+)-JQ1(50 mg/kg)处理携带NMC 797移植瘤的小鼠,抑制肿瘤生长。(+)-JQ1(50 mg/kg) 抹消掉携带NMC 797移植瘤的小鼠的NUT核斑点, 与竞争性结合到核染色质相一致。(+)-JQ1(50 mg/kg)处理NMC 797移植瘤, 显著诱导(31级)角蛋白表达。(+)-JQ1(50 mg/kg)处理携带NMC移植瘤的小鼠模型,促进分化,肿瘤衰退,延长寿命。[1](+)-JQ1(50 mg/kg)处理静脉注射MM.1S-luc+细胞,携带原位移植瘤的SCID米色小鼠,与对照组动物相比,显著延长小鼠的总生存期。[2](+)-JQ1(50 mg/kg,腹腔注射)处理携带Raji移植瘤的小鼠,显著提高小鼠寿命。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

+ 展开
  • Cell lines: MC 11060细胞
  • Concentrations: ~500 nM
  • Incubation Time: 48小时
  • Method:

    细胞按每孔500个接种在白色, 384孔微孔板,孔中含总体为50 μL的培养基。797, TT和TE10细胞生长在含1% Penicillin/Streptomycin 和 10% FBS的DMEM培养基上。Per403细胞生长在含1 % Penicillin/Streptomycin和20% FBS的DMEM 培养基上。病患衍生的NMC 11060细胞生长在含10% FBS 和1% Penicillin/Streptomycin的RPMI培养基上。通过自动化针转移机将(+)-JQ1置于微量检测板上。使细胞裂解,通过增殖试验测评孔中的总ATP含量。根据剂量,重复测量分析,通过逻辑回归(GraphPad Prism)计算IC50。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带NMC 797移植瘤的小鼠
  • Formulation: 5% DMSO溶于5% 葡萄糖
  • Dosages: 50 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 91 mg/mL warmed (199.12 mM)
Ethanol 91 mg/mL (199.12 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 456.99
化学式

C23H25ClN4O2S

CAS号 1268524-70-4
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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操作手册

如果有其他问题,请给我们留言。

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常见问题及建议解决方法

  • 问题 1:

    How can I reconstitute the compound for in vivo injection?

  • 回答:

    JQ1 does not dissolve in water/PBS. The vehicle we recommend is 2% DMSO+30% PEG 300+5% Tween 80+ddH2O. The compound can be dissolved in the vehicle at 5mg/ml and you can use it for IV injection.

Epigenetic Reader Domain Signaling Pathway Map

Epigenetic Reader Domain Inhibitors with Unique Features

Tags: 购买(+)-JQ1 | (+)-JQ1供应商 | 采购(+)-JQ1 | (+)-JQ1价格 | (+)-JQ1生产 | 订购(+)-JQ1 | (+)-JQ1代理商
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID