(+)-JQ1

目录号:S7110

(+)-JQ1 Chemical Structure

Molecular Weight(MW): 456.99

(+)-JQ1是一种BET bromodomain抑制剂,作用于BRD4(1/2),无细胞试验中IC50为77 nM/33 nM,结合到BET家族的所有溴结构域,而不结合到BET家族以外的溴结构域。

规格 价格 库存 购买数量  
RMB 2227.39 现货
RMB 4667.45 现货
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客户使用Selleck该产品发表文献13篇:

客户使用该产品的9个实验数据:

  • The BET protein inhibitor JQ1 reduces c-Myc expression and attenuates primary MCC cell proliferation. A, decreased c-Myc expression in MCC-3 and MCC-5 treated with JQ1 (800 nmol/L) for 72 hours by qRT-PCR and immunoblotting. The mRNA expression of target genes was normalized to that of MRPS2 and a value of 1.0 was assigned to the mRNA expression of target genes in the control group (means+SEM; **, P < 0.01 vs. control); b-actin was used as a loading control for immunoblotting.

    Cancer Res 2014 74(23), 7090-102. (+)-JQ1 purchased from Selleck.

    Immunohistochemical staining of xenograft tumor tissues. Immunohistochemical staining of xenograft tumor tissues with the indicated antibodies. p21-, p27-, p57-, and Ki67 positive cells (brown staining) were quantified at x400 magnification (meansSEM;**, P < 0.01;***, P < 0.001 vs. control); scale bars, 10 um.

    Cancer Res 2014 74(23), 7090-102. (+)-JQ1 purchased from Selleck.

  • (D) Effect of JQ1 on alterations of actin cytoskeleton in VEGF-induced HUVECs. The cells were pretreated with DMSO or JQ1 (100 nM) for 6 h, and stimulated with VEGF (10 ng/mL) for 12 h. F-actin (red) and nuclei (blue) were stained with phalloidin and DAPI, respectively. Representative images from 3 independent experiments.

    Sci Rep, 2016, 6:23770.. (+)-JQ1 purchased from Selleck.

    Sensitivity of BEZ235-resistant cells to JQ-1 using the MTT assay.

    Oncotarget, 2016, 6(7):5134-46.. (+)-JQ1 purchased from Selleck.

  • B. Repressed MCC-3 xenograft tumor growth upon combined treatment with MLN0128 and JQ1. Tumor bearing mice were treated with MLN0128 or vehicle at 1 mg/kg/day by oral gavage and JQ1 or vehicle at 50 mg/kg/day by i.p. injection for a period of 30 days. C. A more effective reduction of MCC-3 xenograft tumor growth in the group treated with combined therapy. Fold-reduction of tumor growth was calculated as average tumor growth of control group divided by average tumor growth of treatment group. Tumor growth was calculated as final average tumor volume minus initial average tumor volume in each group.

    Oncotarget, 2016, 7(6):6576-92.. (+)-JQ1 purchased from Selleck.

    Int J Stem Cells, 2018, 11(1):131-140. (+)-JQ1 purchased from Selleck.

  • JQ1 induces cell cycle arrest and apoptosis in Cal27 cells. (C) Cal27 cells were treated with JQ1 for 24 h and whole cell lysates were tested by western blot assays for the expression of cleaved-caspase-3. GAPDH was used as a loading control. (D) Apoptosis of Cal27 cells treated with JQ1 at 0 and 0.5 µM JQ1; *P<0.05 vs. control (the DMSO group)

    Oncol Rep, 2016, 36(4):1989-96.. (+)-JQ1 purchased from Selleck.

    immunofluorescence staining of BRD4 in ACC-LM and ACC-83 cells treated with JQ1 at the concentration of 1 µM for 24 h (×200).

    Biol Res, 2017, 50(1):19. (+)-JQ1 purchased from Selleck.

  • Effect of BET domain family inhibition on AMI damage in cardiomyocytes. (A) LDH and (B) CK-MB activity in the serum. #P<0.01 vs. sham group; @P<0.05 and &P<0.01 vs. AMI group. BET, bromodomain and extra-terminal; AMI, acute myocardial infarction; LDH, lactate dehydrogenase; CK-MB, creatine kinase MB isoenzyme.

    Exp Ther Med, 2015, 10(6):2319-2324.. (+)-JQ1 purchased from Selleck.

产品安全说明书

Epigenetic Reader Domain抑制剂选择性比较

生物活性

产品描述 (+)-JQ1是一种BET bromodomain抑制剂,作用于BRD4(1/2),无细胞试验中IC50为77 nM/33 nM,结合到BET家族的所有溴结构域,而不结合到BET家族以外的溴结构域。
特性 (+)-JQ1比(-)-JQ1更有效。
靶点
BRD4 (2) [1]
(Cell-free assay)
BRD4 (1) [1]
(Cell-free assay)
33 nM 77 nM
体外研究

(+)-JQ1对映体直接结合到BET bromodomain结构域的Kac结合位点。(+)-JQ1(500 nM)与染色质竞争性结合到BRD4,导致NMC细胞分化和生长停滞。通过Ki67染色减少,证明了(+)-JQ1(500 nM)减弱NMC 797和Per403细胞系的快速增殖。(+)-JQ1(500 nM)作用于NMC 797细胞,有效降低BRD4靶基因的表达。(+)-JQ1作用于NMC 11060细胞,抑制细胞活力, IC50为4 nM。[1](+)-JQ1作用于MM细胞系,强抑制MYC表达。(+)-JQ1抑制KMS-34和LR5增殖,IC50分别为 68 nM和98 nM。(+)-JQ1(500 nM)处理MM.1S细胞,导致S期细胞比例明显下降,随之细胞停滞在G0/G1期增多。(+)-JQ1(500 nM)通过β-半乳糖苷酶染色,导致明显的细胞衰老。(+)-JQ1(800 nM)处理CD138+病患衍生的MM样本,显著降低细胞活力。[2] (+)-JQ1抑制LP-1细胞生长,GI50 为98 nM。(+)-JQ1(625 nM)导致LP-1细胞在G0/G1期的百分数增高。(+)-JQ1(500 nM)作用于LP-1细胞,抑制MYC, BRD4 和CDK9表达。[3](+)-JQ1(1 μM)处理潜伏感染的Jurkat T细胞,激活HIV转录。(+)-JQ1(50 μM)作用于Jurkat和HeLa细胞,主要刺激Tat依赖性的HIV转录。(+)-JQ1(5 μM)作用于J-Lat A2细胞,诱导Brd4解离,从而使Tat招募SEC到HIV启动子上,诱导Pol II CTD磷酸化和病毒转录。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K1  NUfvUGcxS2WubDDWbYFjcWyrdImgRZN{[Xl? NYLGUndwOjVyL{WwNE8yODByIH7N NUPwe2l7OjRxNEivO|IhcA>? MVvEUXNQ NFn1O|dqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDpckBjd3SqIHTvd4UuKGGwZDD0bY1mNSCmZYDlcoRmdnRibXHucoVz NWT4[2xzOjZ5MEe4PFE>
BCPAP M2D0VmNmdGxiVnnhZoltcXS7IFHzd4F6 MoLtNlUxNzVyMD:xNFAxKG6P M2KzO|I1NzR6L{eyJIg> NUToZZNjTE2VTx?= MYnpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDic5RpKGSxc3WtJIFv\CC2aX3lMUBl\XCnbnTlcpQhdWGwbnXy NF3xenUzPjdyN{i4NS=>
K1  Ml7CR4VtdCCFeXPs[UBCe3OjeR?= M2Sxe|I2OC93MECvNVAxOCCwTR?= NUn0TWJ1PzJiaB?= NVXNNZdSTE2VTx?= NV;PToM5[XK{ZYP0d{Bk\WyuIHP5Z4xmKGG2IFewM2cyKHCqYYPl NV;Ke2dvOjZ5MEe4PFE>
BCPAP MlHDR4VtdCCFeXPs[UBCe3OjeR?= MmT4NlUxNzVyMD:xNFAxKG6P MlXTO|IhcA>? MmXqSG1UVw>? NFjONWVienKnc4TzJINmdGxiY4njcIUh[XRiR{CvS|EheGijc3W= NFvKeIIzPjdyN{i4NS=>
Hep3B MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe1PI9bOC1zMDFOwG0> MkLNOUBl NIrhOIxFVVOR NYrRdFNqUUN3ME2wMlA5KM7:TR?= NEm3eIozPjV5NUG2Oy=>
HCCLM3 NXj5Oo5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPZNE0yOCEQvF2= M1nPfVUh\A>? NFr5b41FVVOR MVTJR|UxRTBwMUSg{txO MoTDNlY2PzVzNke=
HuH7 MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jafFAuOTBizszN MX61JIQ> M2\heWROW09? M1zLUGlEPTB;MD6yNUDPxE1? MWOyOlU4PTF4Nx?=
HepG2 M1;RVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHkXFdROC1zMDFOwG0> M1rjXVUh\A>? NEKyb|JFVVOR M1K3SWlEPTB;MD6zOEDPxE1? M4Did|I3PTd3MU[3
SMMC7721 M1G0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrkNXMxNTFyIN88US=> NUi2fJJkPSCm M3jqZ2ROW09? MVzJR|UxRTBwNEGg{txO Mm\GNlY2PzVzNke=
BEL7402 NV;KUHBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUCwMVExKM7:TR?= M4TpRlUh\A>? NUjWW2FvTE2VTx?= M4Lkd2lEPTB;MD60O{DPxE1? MluyNlY2PzVzNke=
MHCC97H NWrXWYxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO2eGtGOC1zMDFOwG0> MnrUOUBl NELSe4dFVVOR MVfJR|UxRTBwNEGg{txO NGTPdVUzPjV5NUG2Oy=>
Hep3B NIXEeZJE\WyuIFP5Z4xmKEG|c3H5 NH7CU48xNjFxMD61M|IvPSEQvF2= NG\aWI01QCCq M1;1SGROW09? NYfhUGJWdGWjZIOgeI8h[SC|dXLzeIFvfGmjbDDhZ4N2dXWuYYTpc44hd2ZiSFPDJINmdGy|IHnuJJN2[i2JMTDwbIF{\cLi NH6yfXozPjV5NUG2Oy=>
HCCLM3 NUi2Wpk4S2WubDDDfYNt\SCDc4PhfS=> MXiwMlEwOC53L{KuOUDPxE1? NUHQ[4ZEPDhiaB?= MXvEUXNQ M362V4xm[WS|IITvJIEhe3Wkc4ThcpRq[WxiYXPjeY12dGG2aX;uJI9nKEiFQzDj[YxteyCrbjDzeYIuTzFicHjhd4XDqA>? NUjaOZhmOjZ3N{WxOlc>
Hep3B MUjBdI9xfG:|aYOgRZN{[Xl? NX2zZm0yOC5zL{CuOU8zNjVizszN MW[0PEBp MUDEUXNQ M4rv[4FkfGm4YYTld{Bk[XOyYYPlMVMh[W6mIHPhd5Bie2VvOTDlfJBz\XO|aX;uJIFv\CCrbnT1Z4VlKFCDUmCgZ4xm[X[jZ3WgZZMhf2WubDDhd{BkgXSxY3jyc41mKGNicnXs[YF{\SCrboTvJJRp\SCleYTvdIxie21iZoLvcUBucXSxY3jvcoRzcWF? NYfwVlh3OjZ3N{WxOlc>
HCCLM3 NInhU2VCeG:ydH;zbZMhSXO|YYm= NYizcXFnOC5zL{CuOU8zNjVizszN MVG0PEBp MnvFSG1UVw>? NU\jeG1m[WO2aY\heIV{KGOjc4Dhd4UuOyCjbnSgZ4F{eGG|ZT25JIV5eHKnc4Ppc44h[W6mIHnu[JVk\WRiUFHSVEBkdGWjdnHn[UBieyC5ZXzsJIF{KGO7dH;jbJJwdWViYzDy[Yxm[XOnIHnueI8hfGinIHP5eI9xdGG|bTDmdo9uKG2rdH;jbI9v\HKrYR?= MYGyOlU4PTF4Nx?=
A549 NV3DWXpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLNNE4yNTFyIN88US=> NGf4dII4OiCq MVLpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NVXRSo1WOjZ2MUWyNlU>
H157 NXnOdXVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoCwNE4yNTFyIN88US=> Ml\yO|IhcA>? M4fWSYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NVXV[FZxOjZ2MUWyNlU>
H1299 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6yT48xNjFvMUCg{txO MoGyO|IhcA>? NHqySopqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? M3;OUlI3PDF3MkK1
A549 NEPoWHBHfW6ldHnvckBCe3OjeR?= M1LSUlEwOi53L{Wg{txO MYmxNkBp NYnqbZdoyqC5ZXHrcJkh\GWlcnXhd4VlKEKlbD2yJIxmfmWucx?= MnLQNlY1OTV{MkW=
H1299 NHzaO25HfW6ldHnvckBCe3OjeR?= NV;XTFdGOS9{LkWvOUDPxE1? NF7NfZYyOiCq MYtCpJdm[WuueTDk[YNz\WG|ZXSgRoNtNTJibHX2[Yx{ NIfJfmkzPjRzNUKyOS=>
H157 MoTuSpVv[3Srb36gRZN{[Xl? NVWxfoM4OS9{LkWvOUDPxE1? MojCNVIhcA>? Ml\I[IVkemWjc3XkJGRTPCCneIDy[ZN{cW:w MoLXNlY1OTV{MkW=
H1299 NU\tclBETnWwY4Tpc44hSXO|YYm= M4XDWlEwOi53L{Wg{txO M1i0eVEzKGh? Mnnu[IVkemWjc3XkJGRTPCCneIDy[ZN{cW:w NWPoWphbOjZ2MUWyNlU>
C8161 MmO4R4VtdCCYaXHibYxqfHliQYPzZZk> M{nGclAuOiEQvF2= MXy0JIQ> MoH3SG1UVw>? NYPBWZVv\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MXOyOlM6PzJ{Mx?=
Mel285 MnmxR4VtdCCYaXHibYxqfHliQYPzZZk> NUnHUVFnOC1{IN88US=> NVvwT4h4PCCm MVXEUXNQ M1;FWoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NVTGXnJ{OjZ|OUeyNlM>
Mel290 MlXRR4VtdCCYaXHibYxqfHliQYPzZZk> MUKwMVIh|ryP NV;ROVRHPCCm M4ixXGROW09? M3uzeYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NIL0W3gzPjN7N{KyNy=>
92.1 NWLUVVdCS2WubDDWbYFjcWyrdImgRZN{[Xl? M4rVOlAuOiEQvF2= NEXmRYU1KGR? MoPHSG1UVw>? M1e1VIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NH3SNFIzPjN7N{KyNy=>
Omm1.3 MVzD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NG\xdpoxNTJizszN MoS5OEBl MlSzSG1UVw>? NF;EPJFl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NGm5dYMzPjN7N{KyNy=>
Mel202 NW\xSWg3S2WubDDWbYFjcWyrdImgRZN{[Xl? MYGwMVIh|ryP NFzMPI01KGR? NWTneXRVTE2VTx?= M37kcIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NWix[JNrOjZ|OUeyNlM>
Mel270 MWPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M4n4PFAuOiEQvF2= NUG5ZnFLPCCm MlrpSG1UVw>? MX3k[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NF3LWWEzPjN7N{KyNy=>
Omm1 NVXwRYh5S2WubDDWbYFjcWyrdImgRZN{[Xl? MVGwMVIh|ryP NELIXWw1KGR? M3rBN2ROW09? NEW3cWFl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MmCwNlY{QTd{MkO=
92.1 MknDRZBweHSxc3nzJGF{e2G7 NXixboYzPTByIH7N MkXaOFghcA>? M2C1cGROW09? MYDpcoR2[2W|IHHwc5B1d3Orcx?= MmH5NlY{QTd{MkO=
Omm1.3 M{P2[GFxd3C2b4Ppd{BCe3OjeR?= Mo[wOVAxKG6P NY\KbIplPDhiaB?= NVHJZWozTE2VTx?= NFq5bYJqdmS3Y3XzJIFxd3C2b4Ppdy=> NHjhW|AzPjN7N{KyNy=>
92.1 NH[0dWxE\WyuIFP5Z4xmKEG|c3H5 MXO1NFAhdk1? MnHwNlQwPDhxN{KgbC=> NIj6bHhFVVOR NUHEb3pocW6mdXPld{B1cGViY3XscEBi[2O3bYXsZZRqd25iYYSgd5VjNUdzwrC= NGLUfoMzPjN7N{KyNy=>
Omm1.3 MWLD[YxtKEO7Y3zlJGF{e2G7 MWK1NFAhdk1? M4DVVlI1NzR6L{eyJIg> MUHEUXNQ MW\pcoR2[2W|IITo[UBk\WyuIHHjZ5VufWyjdHnvckBifCC|dXKtS|HDqA>? MoLnNlY{QTd{MkO=
A549 NXqyPHBCTnWwY4Tpc44hSXO|YYm= NFTSfpEyODBxNECwM|ExODBibl2= MmrMNlQhcA>? NWHifXlbfXC{ZXf1cIF1\XNiYX7kJIFkfGm4YYTld{BUUVKWMR?= MV:yOlIyOjF7OR?=
MCF-7 NWTGSFc4TnWwY4Tpc44hSXO|YYm= MVuxNFAwPDByL{GwNFAhdk1? NY\0O21GOjRiaB?= MXz1dJJm\3WuYYTld{BidmRiYXP0bZZifGW|IGPJVnQy MkexNlYzOTJzOUm=
HEK293 MnPqSpVv[3Srb36gRZN{[Xl? NX7BPWp7OTByL{SwNE8yODByIH7N NFWyeFAzPCCq MnXXeZBz\We3bHH0[ZMh[W6mIHHjeIl3[XSnczDTTXJVOQ>? M3LSNVI3OjF{MUm5
858 MX7D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NVTGdoZYOC1zIN88US=> NV32[IlNPSCm MmXtSG1UVw>? MmTv[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MV[yOlIxPjN|Mx?=
DDR2L63V NF;UTYJE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MmrvNE0yKM7:TR?= MmjjOUBl MVjEUXNQ M1HEdYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= MYCyOlIxPjN|Mx?=
BE(2)-C NWHVV5pVS2WubDDWbYFjcWyrdImgRZN{[Xl? MoLCNUDPxE1? MoXpNU01KGR? MYrk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHlic3nncolncWOjboTsfS=> M1;3dlI3ODZ5NE[0
IMR-32 NGnZU|NE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NEPrSFkyKM7:TR?= NFXtPIwyNTRiZB?= NYLDRXR4\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJNq\26rZnnjZY51dHl? NVfZZlF4OjZyNke0OlQ>
JF M3XoZ2NmdGxiVnnhZoltcXS7IFHzd4F6 MUixJO69VQ>? NF:4fmUyNTRiZB?= M{XXfYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDzbYdvcW[rY3HueIx6 M33pXFI3ODZ5NE[0
BE(2)-M17 MnLBR4VtdCCYaXHibYxqfHliQYPzZZk> NVvSVZdOOSEQvF2= MofWNU01KGR? NH;vcVVl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgd4lodmmoaXPhcpRtgQ>? NVrOV3JzOjZyNke0OlQ>
SK-N-SH NGXofmRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NIHZOnYyKM7:TR?= NV;LPFhCOS12IHS= NF;N[2tl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgd4lodmmoaXPhcpRtgQ>? M{H2W|I3ODZ5NE[0
SK-N-DZ  MkjmR4VtdCCYaXHibYxqfHliQYPzZZk> MnLQNUDPxE1? NEf4S5MyNTRiZB?= M1;6dIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDzbYdvcW[rY3HueIx6 NVHnNGs1OjZyNke0OlQ>
HMC-1.1  MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HPNVUuPTByMDDuUS=> MXy0PEBp MmmzSG1UVw>? M3nnfYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NGTHdFAzPjB3NUOwNy=>
HMC-1.2 NVTI[XU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1KwZlUuPTByMDDuUS=> Mm[xOFghcA>? MljhSG1UVw>? MlqzbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NXP1dJM5OjZyNUWzNFM>
ROSA KIT WT  MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTUOU02ODByIH7N NXe5[2ZRPDhiaB?= NVHSfmlFTE2VTx?= NVWxfW5icW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? M3vW[lI3ODV3M{Cz
ROSA KIT D816V NUWyeGlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;2OU02ODByIH7N MUC0PEBp M2XY[2ROW09? MnjVbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M3r1ZlI3ODV3M{Cz
HMC-1.1  MlrGRZBweHSxc3nzJGF{e2G7 NWnJPYczOjByLUWwNFAhdk1? M4XVdVQ5KGh? MXzEUXNQ Mlm1bY5lfWOnczDj[YxtKGGyb4D0c5NqeyCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? M4LjUFI3ODV3M{Cz
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ROSA KIT D816V M{PrVmFxd3C2b4Ppd{BCe3OjeR?= MWOyNFAuPTByMDDuUS=> NETxNm41QCCq NFLNdZNFVVOR MUfpcoR2[2W|IHPlcIwh[XCxcITvd4l{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NYnZVZhFOjZyNUWzNFM>
494H NX;JXmdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWO3NkBp M4K2dGROW09? M4fvSWlEPTB;MD6xNlLDuTBwMEC0JO69VQ>? NF3HS|gzPTl2NEW2Oi=>
493H NXz2d3VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\5TVczKGh? NGrKTYVFVVOR M3ztfWlEPTB;MD6wOFfDuTBwMEC5JO69VQ>? NGPTXJQzPTl2NEW2Oi=>
716H NWHyfllZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnyS4U4OiCq NIjQeXZFVVOR NH7GNoRKSzVyPUCuNlEzyrFyLkCzOEDPxE1? M1job|I2QTR2NU[2
148I MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK2cXE{PzJiaB?= MUPEUXNQ NED6eJNKSzVyPUCuNlg1yrFyLkCzOUDPxE1? MVOyOVk1PDV4Nh?=
98Sc NF;nb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfLcY8yPzJiaB?= MXXEUXNQ NX3zW3p7UUN3ME2wMlEyPcLzMD6wNFQh|ryP MmnzNlU6PDR3Nk[=
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493L MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLQ[mM6PzJiaB?= Mn34SG1UVw>? MojoTWM2OD1yLkC1NOKyOC5yMUGg{txO MUeyOVk1PDV4Nh?=
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SAOS2 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfYO|IhcA>? NGTIenpFVVOR NHnk[nlKSzVyPUCuNlE4yrFyLkCwN{DPxE1? M33ldlI2QTR2NU[2
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SJSA-1 NG\GdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG3Vog4OiCq MXLEUXNQ NVXUOI1vUUN3ME2wMlExOMLzMD6wNVAh|ryP MVSyOVk1PDV4Nh?=
494H NWXL[ZFLSXCxcITvd4l{KEG|c3H5 MWSwMlI2NzBwNT:xMlAh|ryP MmraNlQhcA>? NUfpW3R4TE2VTx?= M3\abolv[3KnYYPld{Bt\X[nbIOgc4Yh[2ynYY\l[EBk[XOyYYPlMVPDqA>? M{m0XlI2QTR2NU[2
148I NE[xbJdCeG:ydH;zbZMhSXO|YYm= MXmwMlI2NzBwNT:xMlAh|ryP NUi2cnJiOjRiaB?= MVLEUXNQ M37RW4lv[3KnYYPld{Bt\X[nbIOgc4Yh[2ynYY\l[EBk[XOyYYPlMVPDqA>? MVeyOVk1PDV4Nh?=
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494H NFTlOJZCeG:ydH;zbZMhSXO|YYm= NXjnNng2OeLCid88US=> NGXTNnE1QCCq NE\qSJhFVVOR MWjpcoR2[2W|IHPlcIwh[XCxcITvd4l{KHOrZ37p[olk[W62bIm= NFLqb4YzPTl2NEW2Oi=>
148I MWLBdI9xfG:|aYOgRZN{[Xl? NYr4O4R4OeLCid88US=> MWW0PEBp M1HvR2ROW09? NH:zZ2tqdmS3Y3XzJINmdGxiYYDvdJRwe2m|IIPp[45q\mmlYX70cJk> MVWyOVk1PDV4Nh?=
OS17 NV;pW2p3SXCxcITvd4l{KEG|c3H5 M2W4RlHjiIoQvF2= NHXuSoc1QCCq NGfSfZhFVVOR NYPMNnRKcW6mdXPld{Bk\WyuIHHwc5B1d3OrczDzbYdvcW[rY3HueIx6 NYq0W4FSOjV7NES1OlY>
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MV4-11  M2PrRmFxd3C2b4Ppd{BCe3OjeR?= NEfzSZczPTBibl2= MXq0PEBp MV7EUXNQ M3;lTolv\HWlZYOgd4lodmmoaXPhcpRtgSCjcH;weI9{cXNiY3;0doVifG2nboSge4l1cCCzdXn6ZZJ1cW6rYh?= MVGyOVA2Ozh{NR?=
MOLM13 M3\Bc2Z2dmO2aX;uJGF{e2G7 MkPpNlUxKG6P MUOyOEBp MnjoSG1UVw>? MYPlcohidmOnczDxeYl7[XK2aX7pZk1qdmS3Y3XkJI1wemVicEKxMEBDUU1uIHHu[EBkdGWjdnXkJHBCWlB? MXyyOVA2Ozh{NR?=
MV4-11  MYLGeY5kfGmxbjDBd5NigQ>? MmrxNlUxKG6P MnOyNlQhcA>? MmfLSG1UVw>? Mn7w[Y5p[W6lZYOgdZVqgmG{dHnubYIucW6mdXPl[EBud3KnIICyNUwhSkmPLDDhcoQh[2ynYY\l[EBRSVKS NV60WVJJOjVyNUO4NlU>
MOLM13 NH33NJJCeG:ydH;zbZMhSXO|YYm= NX7jR3BFOjVyIH7N MnLYOFghcA>? NUnTdpFHTE2VTx?= NIjwSnFqdmS3Y3XzJJNq\26rZnnjZY51dHliYYDvdJRwe2m|IHPveJJm[XSvZX70JJdqfGhicH;uZZRqdmmk M3T6N|I2ODV|OEK1
MV4-11  Ml[zRZBweHSxc3nzJGF{e2G7 MYCyOVAhdk1? MXq0PEBp M1jpe2ROW09? NETp[5ZqdmS3Y3XzJJNq\26rZnnjZY51dHliYYDvdJRwe2m|IHPveJJm[XSvZX70JJdqfGhicH;uZZRqdmmk Mn7SNlUxPTN6MkW=
Hela NXu4WGY3S2WubDDWbYFjcWyrdImgRZN{[Xl? M3PndVAuPTByIH7N NGW4TZI4OiCq NWfTW5ZqTE2VTx?= NXvWZWVF\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NWLhTVV2OjVyMEmyPVU>
HBL-1 NGnvb2RE\WyuIG\pZYJqdGm2eTDBd5NigQ>? Mn3QNE02ODBibl2= NGXk[FI4OiCq NHewN21FVVOR NGnmT|Jl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NWS3d5hMOjVyMEmyPVU>
HLY-1 M4WxT2NmdGxiVnnhZoltcXS7IFHzd4F6 NVrNTmJ{OC13MECgcm0> NVXvSIlqPzJiaB?= MXfEUXNQ NEnoXppl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M13oO|I2ODB7Mkm1
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SU-DHL-4 M33qOWNmdGxiVnnhZoltcXS7IFHzd4F6 M17VbFAuPTByIH7N NVXx[ZFGPzJiaB?= Ml7LSG1UVw>? NXu4PZJQ\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NHS1N2UzPTByOUK5OS=>
SU-DHL-5 NX;6XVBCS2WubDDWbYFjcWyrdImgRZN{[Xl? MoSwNE02ODBibl2= M3TTZVczKGh? NGi3[3JFVVOR NYTFV3BY\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NVXNdVhFOjVyMEmyPVU>
SU-DHL-6 NGLVc3lE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NG\3fJQxNTVyMDDuUS=> Ml\tO|IhcA>? M4WwemROW09? MUHk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MlHhNlUxODl{OUW=
SU-DHL-10 MWjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MVKwMVUxOCCwTR?= NYXwTI13PzJiaB?= MoDFSG1UVw>? M{LVRoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3XE[VI2ODB7Mkm1
RC-K8 NYPkdZY5S2WubDDWbYFjcWyrdImgRZN{[Xl? M1z5PVAuPTByIH7N NEL4fmg4OiCq MmfuSG1UVw>? NEmwWHBl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NELXT2UzPTByOUK5OS=>
OCI-Ly8 M3TtPWNmdGxiVnnhZoltcXS7IFHzd4F6 Mk[2NE02ODBibl2= MVe3NkBp MmXFSG1UVw>? M3XNUIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NI\YUI8zPTByOUK5OS=>
OCL-Ly18 MVTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MYmwMVUxOCCwTR?= NVnFS28zPzJiaB?= M{HteWROW09? M1\MVYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M2nRZ|I2ODB7Mkm1
OCI-Ly3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXWxO|IwOjVyL{WwNEBvVQ>? MVKyM|ch\A>? MWrEUXNQ NHz6ZZZqdmS3Y3XzJINmdGxvY4njcIUh[XK{ZYP0JIF1KHO3Yj3HNUB4cXSqIH3pcolu[WxiY3XscEBl\WG2aNMg M2K3PVI2ODB7Mkm1
OCI-Ly8 Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17TclE4Oi9{NUCvOVAxKG6P NYfxWnE1Oi95IHS= MYrEUXNQ NF3QUGhqdmS3Y3XzJINmdGxvY4njcIUh[XK{ZYP0JIF1KHO3Yj3HNUB4cXSqIH3pcolu[WxiY3XscEBl\WG2aNMg MkjJNlUxODl{OUW=
SU-DHL-4 Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWxO|IwOjVyL{WwNEBvVQ>? NFjNeW4zNzdiZB?= NV3xZnFbTE2VTx?= MWLpcoR2[2W|IHPlcIwu[3mlbHWgZZJz\XO2IHH0JJN2[i2JMTD3bZRpKG2rbnntZYwh[2WubDDk[YF1cMLi NYDPfnVTOjVyMEmyPVU>
SU-DHL-10 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUCxO|IwOjVyL{WwNEBvVQ>? MXSyM|ch\A>? MnjhSG1UVw>? M{LJUYlv\HWlZYOgZ4VtdC2leXPs[UBienKnc4SgZZQhe3WkLVexJJdqfGhibXnubY1idCClZXzsJIRm[XSqwrC= MmXwNlUxODl{OUW=
OCI-Ly3 NYeyT3hQSXCxcITvd4l{KEG|c3H5 MonUNVczNzJ3MDDuUS=> MkHCO4Q> NG\Se45FVVOR MmXpbY5kemWjc3XzJINie3Cjc3WtN{84KGGldHn2bZR6yqC|aXfubYZq[2GwdHz5 M3[5Z|I2ODB7Mkm1
OCI-Ly8 MmrwRZBweHSxc3nzJGF{e2G7 MW[xO|IwOjVyIH7N NHna[HQ4\A>? M1G3SGROW09? MYLpcoNz\WG|ZYOgZ4F{eGG|ZT2zM|ch[WO2aY\peJnDqHOrZ37p[olk[W62bIm= NIfHUlgzPTByOUK5OS=>
SU-DHL-4 NX3KUZNSSXCxcITvd4l{KEG|c3H5 NVfKSox2OTd{L{K1NEBvVQ>? MYi3[C=> NGr1eIZFVVOR NHHIN3JqdmO{ZXHz[ZMh[2G|cHHz[U0{NzdiYXP0bZZqfHoEoIPp[45q\mmlYX70cJk> MUKyOVAxQTJ7NR?=
SU-DHL-10 MmP4RZBweHSxc3nzJGF{e2G7 M1K3Z|E4Oi9{NUCgcm0> NUO0U4p5P2R? NXTVPHFMTE2VTx?= NIPTUIFqdmO{ZXHz[ZMh[2G|cHHz[U0{NzdiYXP0bZZqfHoEoIPp[45q\mmlYX70cJk> M1TMZ|I2ODB7Mkm1

... Click to View More Cell Line Experimental Data

体内研究 (+)-JQ1(50 mg/kg)处理携带NMC 797移植瘤的小鼠,抑制肿瘤生长。(+)-JQ1(50 mg/kg) 抹消掉携带NMC 797移植瘤的小鼠的NUT核斑点, 与竞争性结合到核染色质相一致。(+)-JQ1(50 mg/kg)处理NMC 797移植瘤, 显著诱导(31级)角蛋白表达。(+)-JQ1(50 mg/kg)处理携带NMC移植瘤的小鼠模型,促进分化,肿瘤衰退,延长寿命。[1](+)-JQ1(50 mg/kg)处理静脉注射MM.1S-luc+细胞,携带原位移植瘤的SCID米色小鼠,与对照组动物相比,显著延长小鼠的总生存期。[2](+)-JQ1(50 mg/kg,腹腔注射)处理携带Raji移植瘤的小鼠,显著提高小鼠寿命。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

+ 展开
  • Cell lines: MC 11060细胞
  • Concentrations: ~500 nM
  • Incubation Time: 48小时
  • Method:

    细胞按每孔500个接种在白色, 384孔微孔板,孔中含总体为50 μL的培养基。797, TT和TE10细胞生长在含1% Penicillin/Streptomycin 和 10% FBS的DMEM培养基上。Per403细胞生长在含1 % Penicillin/Streptomycin和20% FBS的DMEM 培养基上。病患衍生的NMC 11060细胞生长在含10% FBS 和1% Penicillin/Streptomycin的RPMI培养基上。通过自动化针转移机将(+)-JQ1置于微量检测板上。使细胞裂解,通过增殖试验测评孔中的总ATP含量。根据剂量,重复测量分析,通过逻辑回归(GraphPad Prism)计算IC50。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带NMC 797移植瘤的小鼠
  • Formulation: 5% DMSO溶于5% 葡萄糖
  • Dosages: 50 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 91 mg/mL warmed (199.12 mM)
Ethanol 91 mg/mL (199.12 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 456.99
化学式

C23H25ClN4O2S

CAS号 1268524-70-4
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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操作手册

如果有其他问题,请给我们留言。

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常见问题及建议解决方法

  • 问题 1:

    How can I reconstitute the compound for in vivo injection?

  • 回答:

    JQ1 does not dissolve in water/PBS. The vehicle we recommend is 2% DMSO+30% PEG 300+5% Tween 80+ddH2O. The compound can be dissolved in the vehicle at 5mg/ml and you can use it for IV injection.

Epigenetic Reader Domain Signaling Pathway Map

Epigenetic Reader Domain Inhibitors with Unique Features

Tags: 购买(+)-JQ1 | (+)-JQ1供应商 | 采购(+)-JQ1 | (+)-JQ1价格 | (+)-JQ1生产 | 订购(+)-JQ1 | (+)-JQ1代理商
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID