Lenalidomide (CC-5013)

目录号:S1029 中文名称:来那度胺

仅限科研使用

Lenalidomide (CC-5013)是一种TNF-α分泌抑制剂,在PBMCs中IC50为13 nM。Lenalidomide (CC-5013) 是 ubiquitin E3 ligase cereblon (CRBN) 的配体,它通过CRBN-CRL4泛素连接酶引起两个淋巴样转录因子IKZF1和IKZF3的选择性泛素化和降解。Lenalidomide 可促进 cleaved caspase-3 的表达、抑制 VEGF 的表达并诱导凋亡。

Lenalidomide (CC-5013) Chemical Structure

CAS: 191732-72-6

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1557.33 现货
RMB 573.3 现货
RMB 1190.39 现货
RMB 4681.34 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Lenalidomide (CC-5013)发表文献136篇:

产品安全说明书

E3 ligase Ligand抑制剂选择性比较

生物活性

产品描述 Lenalidomide (CC-5013)是一种TNF-α分泌抑制剂,在PBMCs中IC50为13 nM。Lenalidomide (CC-5013) 是 ubiquitin E3 ligase cereblon (CRBN) 的配体,它通过CRBN-CRL4泛素连接酶引起两个淋巴样转录因子IKZF1和IKZF3的选择性泛素化和降解。Lenalidomide 可促进 cleaved caspase-3 的表达、抑制 VEGF 的表达并诱导凋亡。
靶点
CRBN [3] VEGF [1] TNF-α [1]
(PBMCs)
13 nM
体外研究

CC-5013强诱导IL-2和sIL-2R产量。CC-5013作用于T细胞,诱导CD28的酪氨酸磷酸化,随后下调NF-κB的激活。[2] Lenalidomide和Pomalidomide作用于表达与Thalidomide结合野生型CRBN的,而不是Thalidomide结合缺陷型CRBN(YW/AA)的HEK293 T细胞,抑制CRBN自体泛素化。KMS12多发性骨髓瘤细胞中,CRBN野生型蛋白而不是CRBN(YW/AA) 突变型蛋白的过表达, 放大Pomalidomide调节的c-myc和IRF4表达降低和p21(WAF-1) 表达增高。H929 多发性骨髓瘤细胞系中长期抗Lenalidomide 的选择性与CRBN降低相关,然而抗Pomalidomide和 Lenalidomide的DF15R多发性骨髓瘤 中, 检测不到CRBN蛋白。[3] Lenalidomide通过下调肿瘤细胞抑制性分子表达而抑制缺陷发生。Lenalidomide防止肿瘤诱导的T细胞裂解功能障碍发生。Lenalidomide 作用于T细胞,抑制慢性淋巴细胞性白血病(CLL)细胞诱导的T细胞肌动蛋白突触功能受损, 且下调CLL抑制配体及其他受体的表达。Lenalidomide 作用于FL, DLBCL, HL, MM, SCC,和 OC,抑制肿瘤诱导的免疫抑制,且作用于所有检测的肿瘤细胞时,下调免疫抑制配体表达。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LB771-HNC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HEUmlEPTB;Mj6xOVA{QCEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
L-363 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrIN|hTUUN3ME2yMlkzOjF{IN88US=> MoDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
JAR M4O4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJwOUewNFEh|ryP NF7ycYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
EoL-1-cell M4Djfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfMTWM2OD12LkGwOVE2KM7:TR?= NF:1V2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
BT-549 NVz5VWVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCySW1tUUN3ME22MlIyQDR7IN88US=> NYf2d5hsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
SK-NEP-1 NWi2SnFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrMOpJsUUN3ME23Mlg6PTF{IN88US=> M3ztb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
BV-173 M{m2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDIdHFWUUN3ME24MlY4PTh3IN88US=> M2fjR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
HMV-II MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTFyLkCxO|Ih|ryP MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
HCC1806 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\ofmVKSzVyPUGxMlQ1PjdizszN NGLETXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
KASUMI-1 M3u4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDle2xKSzVyPUGxMlU4OSEQvF2= NGn2RXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
SK-MEL-28 NYfycmpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD6SJprUUN3ME2xNU46PzZ2IN88US=> NGjPco09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
RPMI-8226 NFTLZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEflUJZKSzVyPUGyMlYzPDFizszN MkDCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
T47D M1H3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHWc3R7UUN3ME2xN{4zODl7IN88US=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
HOP-62 NXXGT|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknXTWM2OD1zMz60PEDPxE1? NVzCTZpCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
A2058 NWrtfJZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OwNWlEPTB;MUOuPFE6QSEQvF2= M1rkblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
SW620 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvvbZhKSzVyPUG0MlI1PzNizszN MkOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
LCLC-103H M{\xNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP1V|RrUUN3ME2xOE41QDl{IN88US=> NYHJdW5tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
HAL-01 NUez[m43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn6TGNKSzVyPUG0MlU4QTZizszN NGTOW5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
PANC-08-13 NI\6PGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrnSW44UUN3ME2xOE46OTB6IN88US=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
COLO-684 NH[4cm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPGWmxwUUN3ME2xOU4{QTd7IN88US=> NI\ZTFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
DEL NHjnUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\YTHFKSzVyPUG1MlQ6QSEQvF2= NEO3fGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
K5 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF4LkG0PFYh|ryP NFjNZ3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
SK-MEL-24 NHW5elRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LVNmlEPTB;MU[uOFY2OiEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
ACN NF\Zd2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF4LkWyPVch|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
H9 NHP1OplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:3TWM2OD1zNj62NlYh|ryP M3K2XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
EM-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PKc2lEPTB;MUeuNVQ{KM7:TR?= NYLx[5BIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
HSC-4 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnaTWM2OD1zNz62OlAyKM7:TR?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
IGROV-1 M4XXT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfNTZJuUUN3ME2xO{44QDNizszN MkjMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
TE-1 NWCzRlFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnWdY9GUUN3ME2xO{46QTZ6IN88US=> NYf2cYx2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
LN-405 M{HaO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvxTWM2OD1zOT65NFc3KM7:TR?= M4HNbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
MSTO-211H M3HZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjxbnRKSzVyPUKwMlM2PzNizszN MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
MOLT-4 NWfhSnpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn0XWJKSzVyPUKwMlU4PTlizszN Mmr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
RS4-11 M3HRZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvQN3dKSzVyPUKyMlE2PjNizszN Ml33QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
ES3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjXeFNKSzVyPUKyMlY6PjNizszN M3rHNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
SBC-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTwTWM2OD1{Mz64Olk3KM7:TR?= NHi0TIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
CTV-1 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MneyTWM2OD1{NT6wNVQ6KM7:TR?= MmDBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
HuP-T3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq1XVRKSzVyPUK1MlQxODlizszN NF7CWWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
HCC2218 NHPjUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfFTWM2OD1{NT61OFA4KM7:TR?= M{P2WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
HDLM-2 M3u5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLhTWM2OD1{OD6yNFI3KM7:TR?= MlvIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
ABC-1 MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jyc2lEPTB;MkmuOlk4PCEQvF2= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
MV-4-11 MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nScmlEPTB;MkmuO|MyPyEQvF2= NGXSe3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
WM-115 NF7tdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO0[HJKSzVyPUOwMlMxQTlizszN NUDxeVRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
SW1990 NFi5[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfkT5pKSzVyPUOwMlM{KM7:TR?= NEnwcZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
HCC70 NV3nN4lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTPTWM2OD1|MD63N|Q3KM7:TR?= NFv5THQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
KYSE-520 NUDMWGdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNyLki4N|kh|ryP NWrzXVExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
JEG-3 NELSSZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTNzLkG2NVQh|ryP NWT1THduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
C8166 NULwS2FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTNzLkKyO|Qh|ryP NEL4TXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
SK-OV-3 M1jJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[5cHlKSzVyPUOxMlY4PTVizszN M1\5S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
NCI-H526 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2W1XGlEPTB;M{KuOlg{KM7:TR?= NVPj[lBSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
NKM-1 MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;qeYhKSzVyPUOyMlk2PjhizszN NIHHU5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
ECC10 NEG0XJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm1TWM2OD1|ND63OFQ{KM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
A2780 M3nHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWyTHlHUUN3ME2zOU4{PjBzIN88US=> NXjLZ4V2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
KY821 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTN3Lke2PFEh|ryP NFjhbIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
MKN1 M4i4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Pq[WlEPTB;M{[uNlE{PyEQvF2= M3KzRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
EKVX NXnIUZR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPTcnBKSzVyPUO3MlQzOTJizszN M3;XUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
EW-16 M{XzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnZTWM2OD1|OD6zPFg2KM7:TR?= MoXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
CTB-1 NY\GS2o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknVTWM2OD1|OT63O|g6KM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
COR-L105 M3nyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmzOFZlUUN3ME20NE41PzR4IN88US=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
NCI-SNU-5 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDC[md6UUN3ME20NU4zODZ7IN88US=> MoDrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
Mewo MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXGN3dKSzVyPUSxMlk5PzFizszN NVfxeZZ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
BCPAP NWjDTGFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX5TWFnUUN3ME20N{44QTF5IN88US=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
KARPAS-45 M1v3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfWTWM2OD12ND6yO|c3KM7:TR?= NVnVb|dKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
NCI-H1693 M13zeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HlVmlEPTB;NE[uOlk5PiEQvF2= NVP5WnBiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
H-EMC-SS NXvXcpo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLTTWM2OD12OD6zNlI1KM7:TR?= NVv2RXI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
697 NIDyW3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIf0ZolKSzVyPUWwMlM2PDVizszN Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
KP-N-YS NFzBZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnuzTWM2OD13Mj6zNVQzKM7:TR?= MoLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
NCI-H1304 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnQeJJKSzVyPUWyMlcxOjRizszN NEnoOGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
NOS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTV{Lki1OVkh|ryP MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
NCI-H2342 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG5TWM2OD13Mz6wOVA5KM7:TR?= NXTkdllzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
KYSE-270 M2jLNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXTfVBKSzVyPUWzMlY{PjRizszN MnHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
LU-135 NIj6ZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnjZ|BKSzVyPUW1MlE5PTNizszN NEHRSGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
OE33 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MontTWM2OD13NT64NVgh|ryP NHXnWZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
ML-2 MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvTVpBKSzVyPUW1Mlk1QDlizszN NWqxe49pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
KMOE-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPMOlNKSzVyPUW2MlI5QTNizszN MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
Daoy MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXUTWM2OD13Nj6zNlA1KM7:TR?= NYPQeFJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
KNS-62 M3fEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTV5LkCxOFIh|ryP NULlUIltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
NBsusSR NFjCcldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT3SGpKSzVyPUW3MlU4ODVizszN M2LRR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
UACC-257 NFG5PHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmwPW1KSzVyPUW4MlYzPjRizszN MnP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
LU-139 NG\HSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HDfGlEPTB;NUiuPFI3KM7:TR?= NGDhR|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
CAL-85-1 NI\hOopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:wdXlLUUN3ME21PE45PjR|IN88US=> M4nJO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
NCI-H720 M3fkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3SN3ZKSzVyPUW4Mlg6PDJizszN NV\qUlRVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
MLMA M{PBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTV7LkC5NUDPxE1? M1XIflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
A3-KAW M1PvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfVWGJKSzVyPUW5MlI5ODlizszN NVTR[YZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
Ramos-2G6-4C10 NHSxRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDQfGdKSzVyPUW5MlYzQDdizszN MoHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
A388 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjYUo9KSzVyPU[wMlQ1QSEQvF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
LAMA-84 NYS2cHlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTZyLkm5NFUh|ryP MonZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
GCT NYrk[|I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n6U2lEPTB;NkGuNFc5PiEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
K-562 Mn[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qzUWlEPTB;NkGuOVM{OyEQvF2= NYGxbY12RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
NCI-H1666 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvhdWhrUUN3ME22NU45PzVizszN MlTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
NCI-H1993 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDQWnptUUN3ME22N{41ODR|IN88US=> MmLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
NCI-H358 NXf6dmZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTZ3LkCxNlEh|ryP NVTWbHo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
NB6 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorvTWM2OD14NT65PFgh|ryP M3rldlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
HCE-T MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XyO2lEPTB;NkeuNFc6QCEQvF2= M3\j[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
DOK Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvWepBwUUN3ME22O{41QTR6IN88US=> NWHlSYN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
HT-1376 M3nxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTZ7LkizNVQh|ryP NYTKT4NNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
NEC8 M3PSfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn75TWM2OD15MD6xNlQ{KM7:TR?= NE\5RVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
G-402 NXza[IVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3pTWM2OD15MD65N|k2KM7:TR?= M4TNSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
GR-ST M2HSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTdzLkG3NkDPxE1? NEHuS4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
QIMR-WIL NX3ifXhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDuNHlKSzVyPUexMlQ1OzRizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
CHP-212 NVW5NHNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXWWpJlUUN3ME23NU46PjVizszN M3PEN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
KU812 NWDFbWxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nV[2lEPTB;N{KuPVcxOiEQvF2= NWXlXVhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
Becker MoTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrxTWVwUUN3ME23N{4yPDh7IN88US=> M{HlSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
ChaGo-K-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\STWM2OD15ND63OFg3KM7:TR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
A498 NULudZBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOxTWM2OD15ND65N|A5KM7:TR?= Mlz4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
NCI-H69 M4O0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDB[mZKSzVyPUe1Mlc3PjNizszN M{jhbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
NCI-H209 M1P0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fUPGlEPTB;N{iuOlE1PyEQvF2= Mn2xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
CAL-33 M3fkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrYNoRKSzVyPUe4Mlk6OzlizszN MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
COLO-680N MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTd7LkGwNFch|ryP MorkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
D-283MED NHXmdoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmwO3JKSzVyPUe5MlgyOiEQvF2= NIfvfm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
ATN-1 NHHyTY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LQcmlEPTB;OEGuNVE5PyEQvF2= NWK3T5NURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
NCI-N87 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf2TWM2OD16MT63Nlk3KM7:TR?= M4Dv[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
MHH-NB-11 NXnnW3NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlWzTWM2OD16MT64PFQ6KM7:TR?= MkX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
HEL NYTsfVR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjEb3RKSzVyPUiyMlQyOzRizszN NInjemU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
NB69 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjiN3hKSzVyPUizMlAxOzNizszN NV7YPYtuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
MPP-89 M3HVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\1NXlKSzVyPUizMlI2PzVizszN NWHheo55RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
COLO-829 NIrlbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjMdJRGUUN3ME24OU41QTF{IN88US=> NFjPT|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
ONS-76 M{[zcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW1W4ZlUUN3ME24OU44QTB6IN88US=> NIS0SYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
EW-3 NHLVd2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;YSWlEPTB;OE[uNlA{OiEQvF2= M{nUfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg1QC9pPmPBUmdGWjxxYU6=
EW-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTh4LkSzN|Yh|ryP NXL5fGNoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
SW900 MlLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor0TWM2OD16Nz6yNFU{KM7:TR?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
MOLT-13 M4fKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2xeFV{UUN3ME24O{4zOjR|IN88US=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
HuP-T4 NGLacZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:y[3dKSzVyPUmxMlA1ODVizszN MkDrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
HCC1419 NEPRWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7H[mtKSzVyPUmxMlY{PzRizszN NUDvVFU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
CAL-72 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInv[GxKSzVyPUmyMlAzOTlizszN NWXrXYhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
Mo-T MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTl{Lke2PVch|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4OFgwLz6VQV7HSXI9N2F-
OC-314 NWLoWo9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfZTWM2OD17Mj64PFIyKM7:TR?= MmniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFQ5Nyd-U1HOS2VTRC:jPh?=
BHT-101 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH0TWM2OD17Mz6xJO69VQ>? NYPBc|VORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
EW-18 NEDTVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvoTWM2OD17Mz64OFYzKM7:TR?= NIG5Tmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5PDhxJ{7TRW5ITVJ:L3G+
TE-12 M3HZNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTl2LkOwOVUh|ryP NX\UeJg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
MDA-MB-361 M{HTbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLSTWM2OD17Nj6wOVE3KM7:TR?= NYTtbpBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDR6Lze+V2FPT0WUPD;hQi=>
DF15 NIHrN4hHfW6ldHnvckBie3OjeR?= MnP5OEBpenN? NE\EOYNKdmS3Y4Tpc44hd2ZiQ2LMOE9EWkKQIIXibZF2cXSrbjDsbYdie2VvbXXkbYF1\WRiYXnvcI9{KGSnZ4Lh[IF1cW:wIHnuJIh2dWGwIFTGNVUh[2WubIOg[ZhxemW|c3nu[{BxVE:FLXXQUE11[WepZXSgZYlwdG:|IHHmeIVzKDRiaILzJIJ6KGy3bXnu[ZNk\W6lZTDiZZNm\CCkZYThMYdidGGldH;zbYRie2ViZX76fY1mKG[{YXft[Y51[XSrb36gZ49ueGynbXXueIF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5yNUOg{txONg>? NYG0V25iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizOVg2ODdpPkK4N|U5PTB5PD;hQi=>
DF15 NXP5ToI6TnWwY4Tpc44h[XO|YYm= NFTV[3g1KGi{cx?= MmX6TY5lfWO2aX;uJI9nKGOncnXicI9vNW2nZHnheIVlKGmtYYLvd{Bl\We{YXTheIlwdiCrbjDoeY1idiCGRkG1JINmdGy|IHX4dJJme3Orbneg[XBNNXSjZ3fl[EBqc2G{b4OgZYZ1\XJiNDDodpMh[nlibIXtbY5wdWW2cnnjJIFv[Wy7c3nzMEBGSzVyIE2gNE4xPjdizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{NUeyNEc,Ojh2MkW3NlA9N2F-
DF15 M2\MbWZ2dmO2aX;uJIF{e2G7 MYS0JIhzew>? M33qfWlv\HWldHnvckBw\iClZYLlZoxwdi2vZXTpZZRm\CCjaX;sc5Mh\GWpcnHkZZRqd25iaX6gbJVu[W5iRF[xOUBk\WyuczDlfJBz\XO|aX7nJIVRVC22YXfn[YQh[WmxbH;zJIFnfGW{IESgbJJ{KGK7IHz1cYlvd22ndILpZ{BidmGueYPpd{whTUN3MDC9JFAvODh5IN88UU4> NGHKbpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESyOVczOCd-Mki0NlU4OjB:L3G+
T-cells MkDXSpVv[3Srb36gZZN{[Xl? NIjMTGwzKHSxIEOg[IF6ew>? MVnJcohq[mm2aX;uJI9nKEmOLUKgdJJw\HWldHnvckBqdiCqdX3hckBVKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEKgeI8hOyCmYYnzJIJ6KEWOSWPBMEBGSzVyIE2gNE4yPSEQvF2u NYXsZXF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOlgxOTlpPkKzNVY5ODF7PD;hQi=>
NAMALWA NUPqeGZLSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUTZ[4FYPzJiaILz NX7EWHR3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDORW1CVFeDIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhYzOKXYTofY1q\GmwZTDpcoNwenCxcnH0bY9vKGGodHXyJFczKGi{czDifUB{[2mwdHnscIF1cW:wIHPveY51cW6pLDDJR|UxKD1iMD6zOkDPxE1w MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF4OECxPUc,OjNzNkiwNVk9N2F-
CD34+ progenitor cells NGPufpdHfW6ldHnvckBie3OjeR?= NUHjWWRMOTRiZHH5dy=> M1XubWRm[3KnYYPlJIlvKGW{eYTodo9q\CCmaX\m[ZJmdnSrYYTpc44hd2ZiQ1SzOEsheHKxZ3XubZRweiClZXzsd{Bnem:vIH35[Yxw\Hm|cHzhd5Rq[yC|eX7kdo9u\SCmZXyoOZEqKHCjdHnlcpQh[XO|ZYPz[YQh[XNiQ1SzOkBmgHC{ZYPzbY9vKGGodHXyJFE1KGSjeYO= NIrhV|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W3OlkzPCd-MUe1O|Y6OjR:L3G+
CD34+ progenitor cells NHLNUoVHfW6ldHnvckBie3OjeR?= M{WyWVE1KGSjeYO= NFjVbmdF\WO{ZXHz[UBqdiCveXXsc4llKGSrZn\ldoVvfGmjdHnvckBw\iCFREO0L{Bxem:pZX7peI9zKGOnbHzzJIZzd21ibYnlcI9lgXOybHHzeIlkKHO7bnTyc41mKGSnbDi1dUkheGG2aXXueEBie3Onc4Pl[EBieyCFREOzJIV5eHKnc4Ppc44h[W[2ZYKgNVQh\GG7cx?= M{SyPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUe2PVI1Lz5zN{W3OlkzPDxxYU6=
CD34+ progenitor cells Mn7SSpVv[3Srb36gZZN{[Xl? MoXQNVQh\GG7cx?= MkW4SIVkemWjc3WgbY4h\XK7dHjyc4llKGSrZn\ldoVvfGmjdHnvckBw\iCFREO0L{Bxem:pZX7peI9zKGOnbHzzJIZzd21ibYnlcI9lgXOybHHzeIlkKHO7bnTyc41mKGSnbDi1dUkheGG2aXXueEBie3Onc4Pl[EBieyCpbInjc5Bpd3KrbjDBJIV5eHKnc4Ppc44h[W[2ZYKgNVQh\GG7cx?= NWLSRZpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1O|Y6OjRpPkG3OVc3QTJ2PD;hQi=>
CD34+ progenitor cells NHLKZ4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1zw[|E1KGSjeYO= MnHFTY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25ib3[gR2Q{PCticILv[4VvcXSxcjDj[YxteyCocn;tJI16\WyxZInzdIxie3SrYzDzfY5lem:vZTDk[YwpPXFrIIDheIlmdnRiYX\0[ZIhOTRiZHH5dy=> M3LvU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUe2PVI1Lz5zN{W3OlkzPDxxYU6=
CD34+ progenitor cells M{PXcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfXNVQh\GG7cx?= MYTHdo94fGhiaX7obYJqfGmxbjDv[kBETDN2KzDwdo9o\W6rdH;yJINmdGy|IH\yc40hdm:wLXTlcEg2eSlibYnlcI9lgXOybHHzeIlkKHO7bnTyc41mKHCjdHnlcpQh[W[2ZYKgNVQh\GG7cx?= NUjhZmhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1O|Y6OjRpPkG3OVc3QTJ2PD;hQi=>
DF15 MYjGeY5kfGmxbjDhd5NigQ>? NIjtc2oxNjFidH:gNVAhfU1? M{DFN|UhcHK| MU\JcoR2[3Srb36gc4Yh[2W{ZXLsc44udWWmaXH0[YQh[WmxbH;zJIRm\3KjZHH0bY9vKGmwIHj1cYFvKESIMUWgZ4VtdHNiYYSgNE4yKHSxIEGwJJVOKGGodHXyJFUhcHK|IHL5JIludXWwb3Lsc5Qh[W6jbInzbZM> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{NUeyNEc,Ojh2MkW3NlA9N2F-
OPM2 NVfyV5ZWTnWwY4Tpc44h[XO|YYm= Mnr0NE4yKHSxIEGwJJVO Mmf1OUBpenN? M4XhXWlv\HWldHnvckBw\iClZYLlZoxwdi2vZXTpZZRm\CCjaX;sc5Mh\GWpcnHkZZRqd25iaX6gbJVu[W5iT2DNNkBk\WyuczDheEAxNjFidH:gNVAhfU1iYX\0[ZIhPSCqcoOgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>? Ml7CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MkW3NlAoRjJ6NEK1O|IxRC:jPh?=
DF15 M{LKbmZ2dmO2aX;uJIF{e2G7 M13mblAvOSC2bzCxNEB2VQ>? NH7mWok2KGi{cx?= M1[3TWlv\HWldHnvckBw\iClZYLlZoxwdi2vZXTpZZRm\CCra3Hyc5Mh\GWpcnHkZZRqd25iaX6gbJVu[W5iRF[xOUBk\WyuczDheEAxNjFidH:gNVAhfU1iYX\0[ZIhPSCqcoOgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>? MkX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MkW3NlAoRjJ6NEK1O|IxRC:jPh?=
OPM2 NGOybnRHfW6ldHnvckBie3OjeR?= M320cVAvOSC2bzCxNEB2VQ>? NUnHOZpXPSCqcoO= NYCzeJh5UW6mdXP0bY9vKG:oIHPldoVjdG:wLX3l[IlifGWmIHnrZZJweyCmZXfyZYRifGmxbjDpckBpfW2jbjDPVG0zKGOnbHzzJIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB3IHjyd{BjgSCrbX31co9jdG:2IHHuZYx6e2m| NYrVfGN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlU4OjBpPkK4OFI2PzJyPD;hQi=>
EC9706 MorCRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MV2xOVAhfWdxbVy= Mn[zOFghcHK| NGHL[ZFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXDPVcxPiClZXzsd{BifCBzNUCgeYcwdUxiYX\0[ZIhPDhiaILzJIJ6KEOFSz24JIF{e2G7 Mor2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NUewOlYoRjJ6N{W3NFY3RC:jPh?=
Assay
Methods Test Index PMID
Western blot phospho-IKKβ / IKKβ MDM2 / p-MDM2 / p-p53 / p53 22698399 22525275
Growth inhibition assay Cell viability 22698399
体内研究 口服处理Lenalidomide,显著抑制bFGF诱导的血管生成,这种作用存在剂量依赖性。Lenalidomide 显著降低血管面积百分数,从对照组的5.16%降低到实验组的2.58(50 mg/kg剂量处理)和 1.69(250 mg/kg 剂量处理)。 Lenalidomide 显著降低全部MVL,从对照组的21.07降低到实验组的8.11(50 mg/kg剂量处理)和1.90(250 mg/kg剂量处理)。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

  • Assay for inhibition of TNF synthesis by human PBMCs:

    Human PBMCs from normal donors are obtained by Ficoll−Hypaque density centrifugation. Cells (106 cells/mL) are cultured in RPMI supplemented with 10 AB+ serum, 2 mM l-glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin. Lenalidomide is dissolved in DMSO at 20 mg/mL; further dilution is done with culture medium. The final DMSO concentration in all assays including the controls is 0.25%. Lenalidomide is added to cells 1 hour prior to the addition of LPS. PBMCs (106 cells/mL) are stimulated with 1 μg/mL of LPS from Salmonella minnesota R595. Cells, in triplicate, are incubated with LPS for 18−20 hours at 37 °C in 5% CO2. Supernatants are then harvested and assayed for cytokine levels. In some experiments, supernatants are kept frozen at −70 °C until use. Cell viability is assayed by Trypan blue exclusion dye method. The concentration of TNFα in the culture supernatants is determined by ELISA. Lenalidomide is assayed in a minimum of three separate experiments. Percent inhibition is determined as 100 × [1 − (cytokine(experimental)/cytokine(control))].

细胞实验: [3]
  • Cell lines: 良性或恶性 B (CLL)细胞, RPMI8226 MM 细胞
  • Concentrations: 1 μM或5 nM
  • Incubation Time: 24小时
  • Method: 使用CellTracker Blue CMAC对良性或恶性B (CLL)细胞(2 × 106)进行染色, 然后使用2 μg/mL金黄色葡萄球菌超抗原(sAg) (SEA 和 SEB) 在37oC下进行脉冲处理30分钟。B细胞和等量T细胞(从原代共培养中纯化的)按200 × g转速离心5分钟,然后与CD8+ T 细胞在37oC下温育10分钟,或者与 CD3+ T细胞温育20分钟。使用细胞收集器使细胞转移到显微镜载玻片上,然后在室温下和3% 溶于PBS的甲醛混合15分钟。在完全培养基中加入终浓度为1 μM的Lenalidomide。对照组则使用DMSO处理细胞。
动物实验:[5]
  • Animal Models: 携带HUVECs细胞的成年雄性Sprague–Dawley大鼠
  • Dosages: 50 mg/kg和250 mg/kg
  • Administration: 腹腔注射

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40%PEG 300+5%Tween80+ddH2O

10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 259.26
化学式

C13H13N3O3

CAS号 191732-72-6
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05344833 Not yet recruiting Drug: Isatuximab|Drug: Lenalidomide Multiple Myeloma University of Illinois at Chicago May 31 2022 Phase 2
NCT05335018 Recruiting Drug: Glofitamab Poseltinib Lenalidomide Relapsed/Refractory Diffuse Large B Cell Lymphoma Seoul National University Hospital May 30 2022 Phase 2
NCT05091372 Not yet recruiting Drug: Belantamab mafodotin|Drug: Lenalidomide Myeloma Multiple M.D. Anderson Cancer Center April 30 2022 Phase 2
NCT04903197 Recruiting Drug: VAY736|Drug: lenalidomide Non-Hodgkin Lymphoma Diffuse Large B Cell Lymphoma Follicular Lymphoma Mantle Cell Lymphoma Marginal Zone Lymphoma Novartis Pharmaceuticals|Novartis January 24 2022 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

* 必填项

请输入您的姓名
请输入您的邮箱地址 请输入一个有效的邮箱地址
请写点东西给我们

常见问题及建议解决方法

问题 1:
What is the formulation for mouse injection(i.p.)?

回答:
This paper has the information you need: http://link.springer.com/article/10.1208/s12248-012-9401-2. Add lenalidomide to the appropriate volume of sterile phosphate-buffered saline (PBS) containing 1% hydrochloric acid (HCl). the pH of this preparation was adjusted to 7.0–7.6 using sodium hydroxide and sterile filtered using a 0.22 μm Steriflip filter.

问题 2:
what is the procedure to resuspend this compound?

回答:
You can resuspend this compund by DMSO, the solubility is about 52 mg/mL (200.57 mM). For in vivo study, you can prepare the working solution with the vehicle of: 30% PEG400/0.5% Tween80/5% propylene glycol for oral administration.