PF-562271

For research use only. Not for use in humans.

目录号:S2890

PF-562271 Chemical Structure

CAS No. 717907-75-0

PF-562271是一种有效的,ATP竞争性的,可逆的FAK抑制剂,无细胞试验中IC50为1.5 nM,作用于FAK比作用于Pyk2选择性高10倍左右,比作用于其他蛋白激酶(除了一些CDKs)选择性高100倍以上。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2862.96 现货
RMB 1392.84 现货
RMB 2194.82 现货
RMB 5469.68 现货
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客户使用Selleck生产的PF-562271发表文献87篇:

产品安全说明书

FAK抑制剂选择性比较

生物活性

产品描述 PF-562271是一种有效的,ATP竞争性的,可逆的FAK抑制剂,无细胞试验中IC50为1.5 nM,作用于FAK比作用于Pyk2选择性高10倍左右,比作用于其他蛋白激酶(除了一些CDKs)选择性高100倍以上。
靶点
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
体外研究

PF-562271会结合到ATP与FAK结合的部位,在激酶铰链区形成抑制剂与主链原子之间的两种氢键。PF-562271在测量FAK磷酸化可诱导的基于细胞的分析中效果很好,IC50为5 nM。PF-562271 (3.3 μM)导致PC3-M细胞周期停滞在G1期[1]。在鸡胚绒毛尿囊膜实验中PF-562271 (1nM)阻断bFGF刺激的血管生成。 PF-262271 强有效的阻断血管生长但对血管渗漏没有明显影响[2]。PF-562271 (250 nM)可以完全抑制整体A431 细胞侵入胶原蛋白中[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 NVf0cI5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jjXWlEPTB;MD6yO|Y3KM7:TR?= MYDTRW5ITVJ?
SW982 NHPoV5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPITWM2OD1yLkOyPFIh|ryP MVHTRW5ITVJ?
KM12 NX62eXZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrOWXFKSzVyPUCuN|g2PTdizszN MXXTRW5ITVJ?
COLO-205 NGXnfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDvTWM2OD1yLkS4OlU5KM7:TR?= NUfQ[GhFW0GQR1XS
COLO-829 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGzXHJKSzVyPUCuO|UyPzZizszN MXHTRW5ITVJ?
MG-63 M3PEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHGTWM2OD1yLkiwOlM4KM7:TR?= NHz2T2NUSU6JRWK=
IGROV-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwOEGwN|gh|ryP NVPsbpc{W0GQR1XS
NCI-H650 M4fxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwOEOxOVQh|ryP MVjTRW5ITVJ?
RT-112 M4W5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\SeGlEPTB;MD65PFQ3KM7:TR?= NEjnTHBUSU6JRWK=
BCPAP MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFwMEGyPFgh|ryP MXXTRW5ITVJ?
ALL-PO MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\TbldKSzVyPUGuNFE2QDRizszN NWW5R4FvW0GQR1XS
KYSE-270 M2fSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwMES3NVQh|ryP MVjTRW5ITVJ?
8305C M3\EN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLp[HpKSzVyPUGuNFk6ODRizszN NH\LWplUSU6JRWK=
NCI-H810 NX\EPVNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HDXmlEPTB;MT6xNFc4PiEQvF2= M{e0[XNCVkeHUh?=
CAL-33 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHMSVJiUUN3ME2xMlEzQTN6IN88US=> M{m0R3NCVkeHUh?=
AN3-CA NY\0bZM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwMkG4Olch|ryP NH\McmJUSU6JRWK=
NKM-1 NGPxeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2K0UGlEPTB;MT6yO|UxPiEQvF2= M4eyc3NCVkeHUh?=
BPH-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjsNY5KSzVyPUGuNlg4PjZizszN MVnTRW5ITVJ?
MES-SA MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\4dHBKSzVyPUGuN|A3QDJizszN MYLTRW5ITVJ?
CAL-62 NXztSZVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFwM{G5NFkh|ryP NHjqZ4RUSU6JRWK=
Detroit562 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwM{WyNlIh|ryP M3S4NHNCVkeHUh?=
KYSE-150 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7lTWM2OD1zLkO1NlM3KM7:TR?= NUfSeJV1W0GQR1XS
SK-UT-1 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrzTWM2OD1zLkS0OlQ4KM7:TR?= MVzTRW5ITVJ?
HUTU-80 NUTUcYhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnOUJQ3UUN3ME2xMlQ1QDh4IN88US=> NYHrdGU6W0GQR1XS
SIG-M5 Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rmc2lEPTB;MT60PFM5PyEQvF2= MVXTRW5ITVJ?
AGS M2n2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnMRpdKSzVyPUGuOVIyOjRizszN NH7vSWZUSU6JRWK=
ST486 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFwNUOyO|gh|ryP MkjWV2FPT0WU
HSC-2 M3r4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7XbVJqUUN3ME2xMlU{QTVizszN MWLTRW5ITVJ?
LCLC-103H NEPm[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwNUW4NVgh|ryP M1j5XXNCVkeHUh?=
BC-1 NX7IWoUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPITWM2OD1zLk[xOlY1KM7:TR?= MmL4V2FPT0WU
CGTH-W-1 NI\jbVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLzPI44UUN3ME2xMlYyPjd7IN88US=> M3rPUXNCVkeHUh?=
MZ1-PC NVe2RZk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LoSmlEPTB;MT62NlMyOiEQvF2= NHLP[YNUSU6JRWK=
SW1710 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\OTG9KSzVyPUGuOlI3OjhizszN M3XrdHNCVkeHUh?=
EW-13 NY[wXJc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV72eYM2UUN3ME2xMlY{PDZ4IN88US=> NGD4WZJUSU6JRWK=
TE-11 NVHFSok1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XoRWlEPTB;MT62N|UzOiEQvF2= NVzybJF1W0GQR1XS
BHY MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwNkW2OlMh|ryP NFW3WGxUSU6JRWK=
ML-2 M33WdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTrTWM2OD1zLk[2PFAzKM7:TR?= NX\iSGl5W0GQR1XS
MEL-JUSO M{HPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwN{K4PVEh|ryP MofwV2FPT0WU
U251 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTFwN{SwN|Eh|ryP Mk\TV2FPT0WU
MHH-ES-1 NEL6T29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofZTWM2OD1zLke5OVY5KM7:TR?= M2ezU3NCVkeHUh?=
CAL-85-1 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTFwOEC0PUDPxE1? MUXTRW5ITVJ?
D-336MG NU\0b5RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwOEW2NVQh|ryP M1fmRnNCVkeHUh?=
VA-ES-BJ MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DEUWlEPTB;MT65NFMyPSEQvF2= NE\hZ4hUSU6JRWK=
MDA-MB-468 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXHTWM2OD1zLkmxNlczKM7:TR?= NXfic5hQW0GQR1XS
MEL-HO NH;iRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW4TWM2OD1zLkm3PVk{KM7:TR?= MWrTRW5ITVJ?
SW954 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\UNFhGUUN3ME2yMlAxOTVzIN88US=> MV7TRW5ITVJ?
LB831-BLC MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG4W|NKSzVyPUKuNFA6QDhizszN NXuxZmJHW0GQR1XS
EW-16 NELtU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP6fnM1UUN3ME2yMlA{QTh|IN88US=> MofJV2FPT0WU
NCI-H460 Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJwMES4N|kh|ryP MXPTRW5ITVJ?
CHP-212 NUexR41wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q1OGlEPTB;Mj6wPVU{QSEQvF2= MoLmV2FPT0WU
MHH-NB-11 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL4Tox2UUN3ME2yMlEzQDF6IN88US=> MXHTRW5ITVJ?
DU-4475 NIX0RZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnkUoxlUUN3ME2yMlE1PzV7IN88US=> NHeze|NUSU6JRWK=
ABC-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJwMkWxPVYh|ryP MonwV2FPT0WU
LOUCY NGrnRllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXWTWM2OD1{LkK2NVI5KM7:TR?= MWjTRW5ITVJ?
LC-2-ad MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJwMk[5OlYh|ryP M3e4[HNCVkeHUh?=
ETK-1 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M124T2lEPTB;Mj6yPFQ3KM7:TR?= MWTTRW5ITVJ?
KYSE-180 NIXiNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf5OldPUUN3ME2yMlI5QDd2IN88US=> MXHTRW5ITVJ?
HOP-92 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwM{C2O|Mh|ryP NIfXNJdUSU6JRWK=
RCC10RGB MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTX[ZNKSzVyPUKuN|I2ODdizszN NFHnTm9USU6JRWK=
KASUMI-1 MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJwM{K4PEDPxE1? MUjTRW5ITVJ?
ACN M17FRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX0TWM2OD1{LkO0O|Q2KM7:TR?= NWTjO3NiW0GQR1XS
BxPC-3 NV3VNJhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u4WmlEPTB;Mj6zOVQ{PiEQvF2= MlfVV2FPT0WU
MONO-MAC-6 M1fMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnFPI1wUUN3ME2yMlQyOjR6IN88US=> NVTnUJNMW0GQR1XS
CAL-39 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJwNEG2Nlgh|ryP NIfaV49USU6JRWK=
CMK MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvicoRKSzVyPUKuOFE4QTVizszN MWTTRW5ITVJ?
MFE-296 MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHETWM2OD1{LkS3O|kzKM7:TR?= MmXYV2FPT0WU
DU-145 M2HheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwNEmxNVgh|ryP NES2TIFUSU6JRWK=
MDA-MB-231 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7aR45mUUN3ME2yMlQ6PTd{IN88US=> MnXIV2FPT0WU
EFO-27 MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfSTWM2OD1{LkWxPFg5KM7:TR?= NInTPGlUSU6JRWK=
SNU-387 NUPkbJh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1eybGlEPTB;Mj61NlgzKM7:TR?= NWHSW2loW0GQR1XS
KYSE-410 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJwNU[1NVch|ryP MUjTRW5ITVJ?
NCCIT MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPmTWM2OD1{LkW3NlQh|ryP NVrvOG5zW0GQR1XS
LXF-289 NUGyc2c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzCTJBKSzVyPUKuOVgzPzNizszN M{LjbHNCVkeHUh?=
HMV-II NV[1[VI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fhTWlEPTB;Mj61PFk6PyEQvF2= NUXOW|l4W0GQR1XS
MOLT-4 NUKxWYhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX3cpRKSzVyPUKuOlA4OTJizszN NI\ndplUSU6JRWK=
KOSC-2 NH7nZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHpTWM2OD1{Lk[zPFc6KM7:TR?= MnzlV2FPT0WU
TUR MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV32NpBqUUN3ME2yMlY2OzZ7IN88US=> M37jNXNCVkeHUh?=
NCI-H2087 M1q5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXUTWM2OD1{LkexOlQ3KM7:TR?= MnS3V2FPT0WU
SCC-15 NH7HXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT2eJJKSzVyPUKuO|UzPTJizszN NYDaTGxJW0GQR1XS
HSC-4 NILMZ3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2POc2lEPTB;Mj63PFM5QSEQvF2= MUjTRW5ITVJ?
G-402 NFzLOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHOUJhHUUN3ME2yMlgyPDR5IN88US=> M1;yd3NCVkeHUh?=
GP5d NV\YOXUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli0TWM2OD1{LkizPFI4KM7:TR?= NIDUZ4NUSU6JRWK=
IGR-1 NE\TZVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvhTWM2OD1{LkizPVg4KM7:TR?= MnTkV2FPT0WU
SK-PN-DW M2\3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwOE[yNFQh|ryP M3n4eHNCVkeHUh?=
OPM-2 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3x[JVKSzVyPUKuPFk6PzhizszN M3fyZXNCVkeHUh?=
5637 NIXOPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\UV2lEPTB;Mj65NlQ{QSEQvF2= MUDTRW5ITVJ?
NCI-H2030 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjnRWZKSzVyPUKuPVgxOjlizszN M{CxRXNCVkeHUh?=
SK-LU-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\qeo9KSzVyPUKuPVg{OzRizszN MWDTRW5ITVJ?
EW-18 NIjJO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vqNWlEPTB;Mz6wOVMzKM7:TR?= Mn7MV2FPT0WU
786-0 M2fJdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHTTGlKSzVyPUOuNFU4QDRizszN NILKcVlUSU6JRWK=
NCI-H1963 Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PPOGlEPTB;Mz6wPFgzPSEQvF2= M1fBXXNCVkeHUh?=
A2780 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILyO45KSzVyPUOuNVA{PDFizszN MkniV2FPT0WU
NCI-H526 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX2Z3N{UUN3ME2zMlE{QTZzIN88US=> MYLTRW5ITVJ?
BHT-101 M{LRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\2OXhKSzVyPUOuNVU4QThizszN MWLTRW5ITVJ?
RPMI-7951 Moj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DvW2lEPTB;Mz6yNFE{PyEQvF2= M1Xl[HNCVkeHUh?=
HL-60 MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;OTWhKSzVyPUOuNlEyPCEQvF2= M1\Od3NCVkeHUh?=
CTV-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDNTWM2OD1|LkK1N|c4KM7:TR?= M3XxVnNCVkeHUh?=
IST-SL1 M2nhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmwc5BTUUN3ME2zMlI6PDZ3IN88US=> MVvTRW5ITVJ?
G-401 NGOwd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTNwMkm4NFgh|ryP NHTncYxUSU6JRWK=
OVCAR-5 M32xR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOzfJFKSzVyPUOuN|Y{PTJizszN NVKyOI95W0GQR1XS
EW-1 NYjCcWdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNwNEC1OFQh|ryP MkLGV2FPT0WU
H4 M4n2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3HZYpKSzVyPUOuOFc2PjlizszN NED5Z2dUSU6JRWK=
EM-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DaZmlEPTB;Mz60PFY4PCEQvF2= MlewV2FPT0WU
RS4-11 M1\0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHlPYdKSzVyPUOuOFg4OTVizszN MULTRW5ITVJ?
NOMO-1 MmS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H2NWlEPTB;Mz60PVIxPCEQvF2= NWX5[FNPW0GQR1XS
HCT-116 NV3YUVBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXITWM2OD1|LkWwO|EyKM7:TR?= NXvZV|UzW0GQR1XS
CAL-120 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNwNUezOUDPxE1? MXnTRW5ITVJ?
CAL-51 M{ftb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTVSppxUUN3ME2zMlU4PjF{IN88US=> M{[3OXNCVkeHUh?=
RVH-421 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK0VVhKSzVyPUOuOlA{OTFizszN M12ydXNCVkeHUh?=
NCI-H2081 M4LFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwNkWyPFgh|ryP MU\TRW5ITVJ?
SBC-5 NVjmSFNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXlTWM2OD1|Lk[3PFgzKM7:TR?= M2PCbHNCVkeHUh?=
RL95-2 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq1TWM2OD1|LkexPFY1KM7:TR?= NWrLdI5IW0GQR1XS
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LC4-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjBfJJFUUN3ME21MlM6OzB|IN88US=> NWDnR4NiW0GQR1XS
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LB1047-RCC NVLh[IJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVWweGVLUUN3ME21MlkxOTR6IN88US=> M4jmbHNCVkeHUh?=
HEL MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX24ZlVGUUN3ME22MlAzOTh6IN88US=> NGLE[|ZUSU6JRWK=
KARPAS-45 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\TTWM2OD14LkCzO|g4KM7:TR?= MWLTRW5ITVJ?
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Calu-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn5OpZkUUN3ME22MlE1Pjh7IN88US=> MVPTRW5ITVJ?
NCI-H1648 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTueIRKSzVyPU[uNVUyPiEQvF2= MX7TRW5ITVJ?
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COLO-824 NYjSeIxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzqT2VWUUN3ME22MlI4QDZ6IN88US=> MmHhV2FPT0WU
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HT-1080 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vNU2lEPTB;Nz63PFU2PSEQvF2= M2e5VHNCVkeHUh?=
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BB30-HNC M3HPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7UUHdmUUN3ME23Mlk1PTV|IN88US=> NVzmTpRzW0GQR1XS
CAKI-1 NEWxcVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnERWNzUUN3ME24MlA3PTJzIN88US=> NH;SVpVUSU6JRWK=
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IPC-298 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37DV2lEPTB;OD6yO|cxQSEQvF2= NFKxUIhUSU6JRWK=
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AM-38 Mo\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnMS2xiUUN3ME24MlgxPDN7IN88US=> NVvrTnBPW0GQR1XS
LoVo M{Tabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXENXl4UUN3ME24Mlk2PTZ4IN88US=> MkHHV2FPT0WU
MKN45 MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS3cFRPUUN3ME24Mlk3ODZ|IN88US=> MWHTRW5ITVJ?
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NCI-H716 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnRTIFGUUN3ME25Mlk{OzJ{IN88US=> MWfTRW5ITVJ?
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NCI-H2052 NI[3PHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrZTHBZUUN3ME2xNE42OTB3IN88US=> Mof4V2FPT0WU
NCI-H2452 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTFyLk[xPFEh|ryP NEL5V3NUSU6JRWK=
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COR-L105 M3XWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFzLkOyN|ch|ryP M3LlVXNCVkeHUh?=
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NCI-H69 NHTHdGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L3W2lEPTB;MUKuNFE{QSEQvF2= M4[zfXNCVkeHUh?=
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NCI-H1437 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\yZnFKSzVyPUGyMlE1PDdizszN MlnWV2FPT0WU
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NCI-H1792 NV\MfGZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTF{LkO4OVEh|ryP NFHtZoFUSU6JRWK=
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HAL-01 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;BTWM2OD1zMj62NVc1KM7:TR?= NH;Eco1USU6JRWK=
NCI-H2141 M4rsbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrRTWM2OD1zMj62OVgh|ryP M{LVNHNCVkeHUh?=
HCC1806 NVPPbJd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OxeGlEPTB;MUKuOlk2OiEQvF2= M4LqWHNCVkeHUh?=
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HT MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHlNY9sUUN3ME2xNk46PDN5IN88US=> M1TiUHNCVkeHUh?=
OE33 MnXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jscmlEPTB;MUKuPVQ2PiEQvF2= MlPzV2FPT0WU
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LB2241-RCC NIn3[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PQcGlEPTB;MUOuNVQ3QSEQvF2= NHfFWlJUSU6JRWK=
CCF-STTG1 M1:3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HFXmlEPTB;MUOuOFA{QSEQvF2= M3jlbnNCVkeHUh?=
RPMI-8402 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfpRVc6UUN3ME2xN{42ODNzIN88US=> MVTTRW5ITVJ?
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CAL-72 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zBPWlEPTB;MUSuNVkxPiEQvF2= MUTTRW5ITVJ?
VMRC-RCZ MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rkZ2lEPTB;MUSuNlM3KM7:TR?= NYfrb3FwW0GQR1XS
YAPC NEDZZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF2LkK0NFch|ryP M2TSW3NCVkeHUh?=
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CAL-12T M1PxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF2LkSzN|Yh|ryP NETGSWlUSU6JRWK=
GAMG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDIT|RxUUN3ME2xOE42PTd5IN88US=> NFfp[GxUSU6JRWK=
BT-20 NISwZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPvTWM2OD1zND65N|g1KM7:TR?= NXfDem5jW0GQR1XS
KALS-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rLN2lEPTB;MUWuNFE2QCEQvF2= MXfTRW5ITVJ?
LS-123 Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPTTWM2OD1zNT6wNVY2KM7:TR?= M4rx[3NCVkeHUh?=
LK-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF3LkC4OlIh|ryP NF3sT5NUSU6JRWK=
NCI-H1770 M{jYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXaTWM2OD1zNT6yPFY5KM7:TR?= NID3bnhUSU6JRWK=
MIA-PaCa-2 MlrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3BVGZKSzVyPUG1MlQyPjNizszN MWLTRW5ITVJ?
DB MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTF3Lk[5OFEh|ryP MknsV2FPT0WU
Becker NE\JWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF3Lki5NlYh|ryP MnXZV2FPT0WU
HT-144 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\oRmlEPTB;MUWuPVQ6PyEQvF2= M4jjVXNCVkeHUh?=
NCI-H2405 MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTF4LkKyNVgh|ryP Mn\iV2FPT0WU
TK10 NFXCNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofpTWM2OD1zNj6zO|QzKM7:TR?= M3SwUXNCVkeHUh?=
THP-1 NF\yOGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfwWndjUUN3ME2xOk41PjZ3IN88US=> M1\wdXNCVkeHUh?=
LB373-MEL-D MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7J[pFKSzVyPUG2MlYyOzhizszN MUTTRW5ITVJ?
SJSA-1 MnrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfyWmhpUUN3ME2xOk46OjF7IN88US=> NGjXeYxUSU6JRWK=
EB2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonwTWM2OD1zNz63OFI3KM7:TR?= MUDTRW5ITVJ?
MN-60 M3rWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu0PFNEUUN3ME2xO{44QTN4IN88US=> NVnvTVVIW0GQR1XS
A253 M2e4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHr[XhKSzVyPUG3MlgzPSEQvF2= MofDV2FPT0WU
CESS MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\STWM2OD1zNz65N|I3KM7:TR?= MWjTRW5ITVJ?
EW-11 M4fS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\2SJVKSzVyPUG3Mlk6PThizszN M1L2WHNCVkeHUh?=
TE-8 M3ztdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLxTWM2OD1zOD6wOlY6KM7:TR?= M3zzcnNCVkeHUh?=
UACC-257 NHjk[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILne4tKSzVyPUG4MlIxPjJizszN NEmybWJUSU6JRWK=
NCI-H226 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DVNmlEPTB;MUiuPFI6QSEQvF2= M2ryV3NCVkeHUh?=
NCI-H748 NGnxbWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF6Lki1PFUh|ryP NGP1VXpUSU6JRWK=
NCI-H1299 NFL2VnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;He4lKSzVyPUG4Mlg6OThizszN M{fFSXNCVkeHUh?=
IST-MEL1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3T[3ZKSzVyPUG5MlE4PTRizszN M3vPO3NCVkeHUh?=
HCC1187 M3\QVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXoTWM2OD1zOT6xO|k3KM7:TR?= MV;TRW5ITVJ?
HT-1376 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLpe41[UUN3ME2xPU4zODJ7IN88US=> MW\TRW5ITVJ?
SK-MEL-2 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\5XmpKSzVyPUG5MlIyPTVizszN MXfTRW5ITVJ?
U031 NV3RcZBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF7LkKyNVkh|ryP NV;6dGs6W0GQR1XS
NCI-H524 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLLS5BrUUN3ME2xPU42PzJ3IN88US=> M3jDW3NCVkeHUh?=
KU812 M2Hoe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfD[mpKSzVyPUG5MlU6PDRizszN NWLXPHl7W0GQR1XS
NB10 NVXDW|JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG4R5RKSzVyPUG5MlYzPjhizszN M1jxNnNCVkeHUh?=
NOS-1 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoC1TWM2OD1{MD6xOVc4KM7:TR?= M3XPSXNCVkeHUh?=
EW-7 M2W2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPmWYNHUUN3ME2yNE4yPjJ6IN88US=> MWHTRW5ITVJ?
Raji NHzQWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLnZ3BKSzVyPUKwMlI2PjhizszN M{[0dnNCVkeHUh?=
LB2518-MEL MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjpfJBKSzVyPUKwMlM6PTNizszN MmO1V2FPT0WU
PANC-10-05 NHH5V21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v2e2lEPTB;MkCuOFYyOyEQvF2= MmfwV2FPT0WU
MZ2-MEL Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvSTWM2OD1{MD61PFE1KM7:TR?= MX7TRW5ITVJ?
MFE-280 NHn5NoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknWTWM2OD1{MT6zNVg5KM7:TR?= NWTmWZJWW0GQR1XS
RKO MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnR[mxKSzVyPUKxMlMzODJizszN M{TDUXNCVkeHUh?=
KMOE-2 NVrLTIU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDlZYVKSzVyPUKxMlMzQDhizszN NFfUO4xUSU6JRWK=
K5 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT4W|FJUUN3ME2yNU4{QDl|IN88US=> MoDKV2FPT0WU
NCI-H64 NUXUOGsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rrWGlEPTB;MkGuOFc2PiEQvF2= MmTsV2FPT0WU
K-562 M2O0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzPdGNEUUN3ME2yNU41QTdzIN88US=> MUHTRW5ITVJ?
HCE-T NV3seYI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXGUJVKSzVyPUKxMlUxQTRizszN NGnEWYlUSU6JRWK=
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PFSK-1 M{\NT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJzLk[4N|ch|ryP Mn3vV2FPT0WU
DOK MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCxWVVKSzVyPUKxMlc3QDdizszN MV\TRW5ITVJ?
NCI-H1882 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LwSGlEPTB;MkGuPFU6PiEQvF2= NEjBdmNUSU6JRWK=
KNS-81-FD MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJzLki2N|Eh|ryP NEnMdWpUSU6JRWK=
OCUB-M NEjvTW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTR[JpKSzVyPUKxMlk3QDhizszN NEXkfHlUSU6JRWK=
NCI-H1694 NVLtN|k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJzLkm4OlMh|ryP M1XoNXNCVkeHUh?=
LS-513 NEfMW5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnMRlNKSzVyPUKyMlA{PjdizszN MXTTRW5ITVJ?
NCI-H2122 NF7uephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJ{LkG2O|ch|ryP MXjTRW5ITVJ?
IMR-5 M13oRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrtT2F7UUN3ME2yNk4zQDdizszN NY\mcZF[W0GQR1XS
SNU-C2B MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi2TWM2OD1{Mj62O|Q3KM7:TR?= NUWy[mczW0GQR1XS
A498 NILTTI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nibmlEPTB;MkKuPFE4PyEQvF2= M3i1WnNCVkeHUh?=
NCI-H727 Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfrRZdKSzVyPUKyMlg5OzZizszN NV;aZ25jW0GQR1XS
SW1573 NV7FTJl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ|LkC2OFYh|ryP NGnwSVlUSU6JRWK=
RO82-W-1 M2r0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDVW3gzUUN3ME2yN{4zPTFzIN88US=> M4PoO3NCVkeHUh?=
SKG-IIIa NUj5OGJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGflTpNKSzVyPUKzMlM2PDZizszN NXuwWZRFW0GQR1XS
MC-CAR NI\kRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HqeWlEPTB;MkOuOVE5OyEQvF2= M3TjdHNCVkeHUh?=
NCI-H446 NWi2c|BFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjWfIdKSzVyPUKzMlYxQTNizszN MkX4V2FPT0WU
PC-14 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\vPZJTUUN3ME2yN{43PjJ|IN88US=> Mn\UV2FPT0WU
TGBC1TKB MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYKyXWJDUUN3ME2yN{44PDZzIN88US=> NX\CfZpMW0GQR1XS
EFM-19 NEPndW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\VVGlEPTB;MkSuNVg1PCEQvF2= MYTTRW5ITVJ?
SK-N-DZ MlqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTITWM2OD1{ND60PVc4KM7:TR?= MlPmV2FPT0WU
NCI-H661 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;YS3BKSzVyPUK0MlUzOTdizszN NEPqU|RUSU6JRWK=
SW1990 NHuzNnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJ2LkW4PFMh|ryP NXWwS2psW0GQR1XS
SW684 NFj0c45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXuPHlKSzVyPUK0Mlc3OjRizszN MX;TRW5ITVJ?
Ca-Ski NUTJb5Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nwZWlEPTB;MkSuPVI{PyEQvF2= NGrodVBUSU6JRWK=
TGW MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJ3LkKzN|ch|ryP NV7WeHN1W0GQR1XS
CaR-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf5TWM2OD1{NT6zOVch|ryP NH3FXZJUSU6JRWK=
D-247MG MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\XNmlEPTB;MkWuOFc1OyEQvF2= MVrTRW5ITVJ?
CCRF-CEM MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEH0[pdKSzVyPUK1Mlc1PTlizszN NX;0eZhSW0GQR1XS
CAPAN-1 NYPRdWF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTwTWM2OD1{NT63OVAyKM7:TR?= NWTQTW17W0GQR1XS
CP50-MEL-B NFrQVIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ3Lkm5NFEh|ryP NUPIU2lJW0GQR1XS
FADU MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\HTWM2OD1{Nj61NVUzKM7:TR?= MWjTRW5ITVJ?
Daudi NHHTRWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ4LkWxOVgh|ryP MYLTRW5ITVJ?
U-87-MG M2noPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnMNm5YUUN3ME2yOk42OzB3IN88US=> NIXSTVlUSU6JRWK=
DSH1 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLv[GVnUUN3ME2yOk42PDB4IN88US=> M3OxfnNCVkeHUh?=
KYSE-520 NFHOOotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;v[mFKSzVyPUK2MlU2PTNizszN M{XySHNCVkeHUh?=
HuH-7 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnPe4tjUUN3ME2yOk46ODh4IN88US=> MXTTRW5ITVJ?
U-2-OS MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ5LkCyO|Eh|ryP MV7TRW5ITVJ?
LU-99A NGH2R2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vtNWlEPTB;MkeuNVc2PCEQvF2= NWHNcGE5W0GQR1XS
T98G M4C1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS1U2RMUUN3ME2yO{4yQTd|IN88US=> NV\STYtSW0GQR1XS
MZ7-mel NEflWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn5UmtzUUN3ME2yO{42PTR6IN88US=> NXW0U|l2W0GQR1XS
SNU-C1 NH3CSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPCXIFKSzVyPUK3MlY1QTFizszN MoPXV2FPT0WU
MDA-MB-175-VII M{f5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\pZVE5UUN3ME2yO{43QTd3IN88US=> M{fZcXNCVkeHUh?=
HuP-T3 NIrqeXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnDbHg6UUN3ME2yPE4xPDl3IN88US=> MlTCV2FPT0WU
T-24 M4OyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LlbGlEPTB;MkiuNVkzPSEQvF2= MkLzV2FPT0WU
HDLM-2 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJ6LkK0OVkh|ryP NHHWXHBUSU6JRWK=
NCI-H1651 NX3j[Wl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu2dnNKSzVyPUK4MlI2QTJizszN NUXmWnBxW0GQR1XS
SK-N-AS MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ6LkOxO|Eh|ryP M4XJcXNCVkeHUh?=
NY MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnJNIg1UUN3ME2yPE43PTd7IN88US=> NYq3U5BPW0GQR1XS
D-283MED MmTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHGZ|lSUUN3ME2yPE45PzB6IN88US=> NH;SV4tUSU6JRWK=
KLE NVXaWGU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXztd|ljUUN3ME2yPE46QTB4IN88US=> NWTpR3lXW0GQR1XS
NCI-H28 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJ7LkCxNkDPxE1? MnnPV2FPT0WU
TE-1 NF\uS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LYW2lEPTB;MkmuNlE3PyEQvF2= MXjTRW5ITVJ?
SK-MEL-24 NYrD[5ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJ7LkW0OlYh|ryP MULTRW5ITVJ?
CAL-54 M3O5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7mTWM2OD1{OT62NFQ3KM7:TR?= MmLZV2FPT0WU
A673 NFG0bGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXYbYVqUUN3ME2yPU44OzJizszN M324PHNCVkeHUh?=
HEC-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjINZBNUUN3ME2zNE4xODV|IN88US=> NXX5enJyW0GQR1XS
LS-411N NUDDWWJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLETWM2OD1|MD6xOFc2KM7:TR?= M{TWdnNCVkeHUh?=
SW962 NVfOR401T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTLd5RxUUN3ME2zNE4zPDd5IN88US=> M3PTTXNCVkeHUh?=
OVCAR-8 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHGOItMUUN3ME2zNE43Pzl2IN88US=> Mn3KV2FPT0WU
NCI-H630 NXrxNGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjvTWM2OD1|MD64PVU{KM7:TR?= NVfNeotWW0GQR1XS
D-263MG NGnrSW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrHRYdKSzVyPUOxMlA1OjRizszN NFjQbmxUSU6JRWK=
NCI-H596 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[4TWM2OD1|MT6wOlIyKM7:TR?= NGf1XG5USU6JRWK=
BB49-HNC MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTNzLkGxNkDPxE1? NEHmeIRUSU6JRWK=
KYSE-70 M2TKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTNzLkOwNFgh|ryP NUe5bHZ5W0GQR1XS
LAN-6 M3HrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr4T5pKSzVyPUOxMlQ6QTJizszN M4DzdXNCVkeHUh?=
NCI-H2228 NVW2UoZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTNzLkW2NlUh|ryP MV;TRW5ITVJ?
SW620 M2joZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrvXIVKSzVyPUOxMlYzQDNizszN M1fPNHNCVkeHUh?=
KM-H2 NV;Mco5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNzLkezNFYh|ryP MnTpV2FPT0WU
DJM-1 NH\kUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH76W2FKSzVyPUOyMlE{QDZizszN M37IUnNCVkeHUh?=
SW48 NETsZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jrc2lEPTB;M{KuN|gzPSEQvF2= M2nRXHNCVkeHUh?=
NCI-H1793 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTPTWM2OD1|Mj62NVY{KM7:TR?= M2jaV3NCVkeHUh?=
LU-165 M3TJXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoThTWM2OD1|Mz6wNFgh|ryP MYrTRW5ITVJ?
EHEB NF\5NHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPWdI1KSzVyPUOzMlA1QTRizszN NXnHbG5[W0GQR1XS
NCI-H441 Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTN|LkKyN|Uh|ryP NFjCNWpUSU6JRWK=
LOXIMVI NVq3ZoJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXftTYR7UUN3ME2zN{4{Pjd7IN88US=> MYHTRW5ITVJ?
MC-IXC MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fqWmlEPTB;M{OuOVY2PSEQvF2= MlLVV2FPT0WU
NCI-H522 Mor6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN|Lk[1OEDPxE1? M3rne3NCVkeHUh?=
IA-LM NInMfpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\nTWM2OD1|Mz62O|Q3KM7:TR?= MV\TRW5ITVJ?
NCI-H1417 M3HGPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorHTWM2OD1|Mz65OVg2KM7:TR?= MWDTRW5ITVJ?
HCC2218 M4PLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;BUXpKSzVyPUO1MlIyQDVizszN MXLTRW5ITVJ?
HC-1 M1jPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HDW2lEPTB;M{WuOFAzPCEQvF2= MmfnV2FPT0WU
HH NFHnVGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XYbGlEPTB;M{WuOFE1OSEQvF2= MUHTRW5ITVJ?
EFE-184 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTN3Lk[4Nlkh|ryP Ml3MV2FPT0WU
NCI-H1355 M{Oxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN3Lke3NVgh|ryP NXLsPZVHW0GQR1XS
BV-173 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\OXXRKSzVyPUO1MlgzPjRizszN M4XhU3NCVkeHUh?=
NEC8 M2Xs[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnziTWM2OD1|Nj60PVI1KM7:TR?= MkS5V2FPT0WU
SW1463 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\zOJNKSzVyPUO2MlY2PjZizszN MWLTRW5ITVJ?
KYSE-140 NFnDeJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHDdZR6UUN3ME2zOk44Ojl6IN88US=> NH[w[IdUSU6JRWK=
no-11 MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLpclFKSzVyPUO2Mlg2OzZizszN MW\TRW5ITVJ?
HCC1937 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInZU3JKSzVyPUO3MlAyPTRizszN NVPUWFZFW0GQR1XS
LNCaP-Clone-FGC NVHhXGliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33uOWlEPTB;M{euNVkxOyEQvF2= NV3jfIJRW0GQR1XS
KARPAS-422 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTN5LkS0N|Eh|ryP NYfmNJQ6W0GQR1XS
RCM-1 NGjkT49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrNT3Z[UUN3ME2zO{42OzV6IN88US=> NHnSRplUSU6JRWK=
A375 MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLLTWM2OD1|Nz63OlQ4KM7:TR?= NX\tOYV[W0GQR1XS
TGBC24TKB NXvaSlJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTN6LkCyN|kh|ryP NX3Ico5rW0GQR1XS
MDA-MB-453 NUDhfYhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTN7LkCyNVgh|ryP MV;TRW5ITVJ?
Capan-2 NFv6VndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTN7LkC1NFkh|ryP MlPWV2FPT0WU
SW756 M4rBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;HSmtKSzVyPUO5MlUxQTFizszN M3G4XXNCVkeHUh?=
KU-19-19 NV[zZ|B4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vYW2lEPTB;M{muOlI5OiEQvF2= M37iO3NCVkeHUh?=
NCI-H2170 NYPF[4s2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfWTWNKSzVyPUO5Mlk6PzdizszN NETaVGpUSU6JRWK=
COLO-678 Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq1TWM2OD12MD61PVUh|ryP NX[wToRQW0GQR1XS
PF-382 NY\jRlVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTRyLke0PFch|ryP NEjwRoNUSU6JRWK=
OAW-42 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj0fYJKSzVyPUSyMlI6PDJizszN NV;zZ4hGW0GQR1XS
LB996-RCC M3r6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDMTWM2OD12Mj64NFA5KM7:TR?= NVi4NFFrW0GQR1XS
SAS M2XPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S0cmlEPTB;NEOuOFI5QCEQvF2= NF7r[4tUSU6JRWK=
MRK-nu-1 NFPYb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFqx[GlKSzVyPUS0Mlc1OTRizszN NWHJTph1W0GQR1XS
EoL-1-cell NEPWZ4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPVeopKSzVyPUS0MlkyOzZizszN NIn6VlhUSU6JRWK=
NCI-H2342 NV60SZpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHHVmtKSzVyPUS1MlEyOTdizszN NF72S4ZUSU6JRWK=
NCI-H1703 M1n4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXrXmlKSzVyPUS2MlA2QTJizszN NWrvRphMW0GQR1XS
NCI-H187 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P2e2lEPTB;NE[uNVg3QSEQvF2= MYTTRW5ITVJ?
CP66-MEL NWXCVXpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTR4LkK3PFkh|ryP M2\3TXNCVkeHUh?=
HCC1569 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljkTWM2OD12Nj61PVE4KM7:TR?= MlvhV2FPT0WU
BL-70 NEDRSlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf3TWM2OD12Nj63O|M4KM7:TR?= NHXxUIFUSU6JRWK=
Saos-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTR5LkOxNlMh|ryP Mkn0V2FPT0WU
LC-1F NU\PfWR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzrTWM2OD12Nz62NVA2KM7:TR?= M3Hs[nNCVkeHUh?=
KY821 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTwTWM2OD12Nz62OFM1KM7:TR?= NVPRflZ6W0GQR1XS
PSN1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTR6LkG0NFEh|ryP M2PuR3NCVkeHUh?=
RT4 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe1XoJKSzVyPUS4Mlg{PzdizszN NIXBd5dUSU6JRWK=
LS-1034 M{fUcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX32PZZkUUN3ME20PE45QTV2IN88US=> MorxV2FPT0WU
NCI-H1395 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jGeGlEPTB;NEmuNFQ6OiEQvF2= MWrTRW5ITVJ?
EKVX M2rG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;ieGlEPTB;NEmuOlc{OSEQvF2= MV3TRW5ITVJ?
IST-MES1 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rqT2lEPTB;NEmuPFk1PCEQvF2= NHn5dmlUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-FAK / FAK / p-Talin / Talin ; 

PubMed: 26530902     


Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells.

p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; 

PubMed: 29417941     


MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.

26530902 29417941
Immunofluorescence
p-FAK; 

PubMed: 26530902     


Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).

26530902
Growth inhibition assay
Cell viability; 

PubMed: 28953264     


MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk (*) and p < 0.01 are designated by two asterisks (**).

28953264
体内研究 在携带U87MG的小鼠中PF-562271 (< 33 mg/kg 口服)抑制肿瘤中FAK磷酸化并具有时间和剂量依赖特性。PF-562271 (50 mg/kg, 口服,一天两次)对BxPc3异种移植小鼠中肿瘤生长抑制率为86% ,对PC3-M异种移植小鼠中肿瘤生长抑制率为45%。PF-562271 (25mg/kg, 一天两次)处理的携带H125肺部异种移植肿瘤凋亡率提高2倍[1]。 PF-562271 (33 mg/kg,口服)24小时后抑制小鼠中肿瘤细胞的广泛运动。PF-562271 (33 mg/kg, 口服)导致小鼠中E-cadherin动力学的改变,这与减弱的E-cadherin依赖的整体细胞运动有关 [3]。在皮下局部异种移植PC3M-luc-C6的小鼠模型中 PF-562271 (25 mg/kg, 口服,一天两次)导致肿瘤生长率62%的抑制[4]。在胫骨植入MDA-MB-231细胞的大鼠中PF-562271 (5mg/kg, 口服)导致骨钙素和松质骨参数显著而相似的增加同时导致肿瘤生长速度和骨愈合信号的下降[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[1]
- 合并
  • Animal Models: 携带BxPc3或 PC3-M异种移植的无胸腺雌性小鼠
  • Dosages: 50 mg/kg
  • Administration: 填喂给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
5 mg/ml

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 507.49
化学式

C21H20F3N7O3S

CAS号 717907-75-0
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

FAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID