PF-562271

For research use only. Not for use in humans.

目录号：S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，无细胞试验中IC50为1.5 nM，作用于FAK比作用于Pyk2选择性高10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2862.96 现货
RMB 1392.84 现货
RMB 2194.82 现货
RMB 5469.68 现货
RMB 7967.47 现货
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客户使用Selleck生产的PF-562271发表文献78篇：

产品安全说明书

FAK抑制剂选择性比较

生物活性

产品描述 PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，无细胞试验中IC50为1.5 nM，作用于FAK比作用于Pyk2选择性高10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。
靶点
FAK [1]
(Cell-free assay)		 PYK2 [1]
(Cell-free assay)		 CDK2/CyclinE [1]
(Cell-free assay)		 CDK3/CyclinE [1]
(Cell-free assay)		 CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
体外研究

PF-562271会结合到ATP与FAK结合的部位,在激酶铰链区形成抑制剂与主链原子之间的两种氢键。PF-562271在测量FAK磷酸化可诱导的基于细胞的分析中效果很好，IC50为5 nM。PF-562271 (3.3 μM)导致PC3-M细胞周期停滞在G1期[1]。在鸡胚绒毛尿囊膜实验中PF-562271 (1nM)阻断bFGF刺激的血管生成。 PF-262271 强有效的阻断血管生长但对血管渗漏没有明显影响[2]。PF-562271 (250 nM)可以完全抑制整体A431 细胞侵入胶原蛋白中[3]。
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 NFXyV3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW0TWM2OD1yLkK3OlYh|ryP NVPwdGRiW0GQR1XS
SW982 NIWzbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LqWmlEPTB;MD6zNlgzKM7:TR?= MmjyV2FPT0WU
KM12 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTxV2VKSzVyPUCuN|g2PTdizszN NE\ZVI5USU6JRWK=
COLO-205 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P5V2lEPTB;MD60PFY2QCEQvF2= NV3iVpJLW0GQR1XS
COLO-829 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknPTWM2OD1yLke1NVc3KM7:TR?= M3rUe3NCVkeHUh?=
MG-63 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD3TG1ZUUN3ME2wMlgxPjN5IN88US=> M1j4R3NCVkeHUh?=
IGROV-1 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS0bFJKSzVyPUCuPFExOzhizszN M{\CR3NCVkeHUh?=
NCI-H650 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TaeWlEPTB;MD64N|E2PCEQvF2= MXHTRW5ITVJ?
RT-112 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFu1W5BKSzVyPUCuPVg1PiEQvF2= NWnjbm43W0GQR1XS
BCPAP MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwMEGyPFgh|ryP M1\r[XNCVkeHUh?=
ALL-PO NIXabpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK3TWM2OD1zLkCxOVg1KM7:TR?= MXjTRW5ITVJ?
KYSE-270 NGTrTGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIi1[YxKSzVyPUGuNFQ4OTRizszN MoHoV2FPT0WU
8305C NUGxZ2l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLOTWM2OD1zLkC5PVA1KM7:TR?= MWPTRW5ITVJ?
NCI-H810 M3v1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXKbppKSzVyPUGuNVA4PzZizszN NEn5cFZUSU6JRWK=
CAL-33 NF\3fopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFwMUK5N|gh|ryP MkDJV2FPT0WU
AN3-CA NEjrTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLVUG9KSzVyPUGuNlE5PjdizszN NYDBbVhNW0GQR1XS
NKM-1 NWjxbGhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorDTWM2OD1zLkK3OVA3KM7:TR?= M1jFSXNCVkeHUh?=
BPH-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPVcHJKSzVyPUGuNlg4PjZizszN NH:0SGRUSU6JRWK=
MES-SA Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDrUZpKSzVyPUGuN|A3QDJizszN M{OzW3NCVkeHUh?=
CAL-62 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXN[|JUUUN3ME2xMlMyQTB7IN88US=> MVnTRW5ITVJ?
Detroit562 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\jTWM2OD1zLkO1NlIzKM7:TR?= NXnXfIwxW0GQR1XS
KYSE-150 NXvrXmVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFwM{WyN|Yh|ryP MnPEV2FPT0WU
SK-UT-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorDTWM2OD1zLkS0OlQ4KM7:TR?= M{nNZnNCVkeHUh?=
HUTU-80 MnHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuwcohKSzVyPUGuOFQ5QDZizszN MXHTRW5ITVJ?
SIG-M5 NFv0OYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzjOXlKSzVyPUGuOFg{QDdizszN M4nyTnNCVkeHUh?=
AGS NIDKZ|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\kTWM2OD1zLkWyNVI1KM7:TR?= M2njNnNCVkeHUh?=
ST486 MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnLOnZHUUN3ME2xMlU{Ojd6IN88US=> MlXTV2FPT0WU
HSC-2 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu2Z5BwUUN3ME2xMlU{QTVizszN NYrVbJg4W0GQR1XS
LCLC-103H NI\aWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFwNUW4NVgh|ryP M{O5NXNCVkeHUh?=
BC-1 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qyV2lEPTB;MT62NVY3PCEQvF2= NFnp[I9USU6JRWK=
CGTH-W-1 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfmXJJKSzVyPUGuOlE3PzlizszN NHPSe3pUSU6JRWK=
MZ1-PC NFu3ZVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;NTWM2OD1zLk[yN|EzKM7:TR?= NYrvW4xQW0GQR1XS
SW1710 M4LVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\PSmZKSzVyPUGuOlI3OjhizszN Mm\jV2FPT0WU
EW-13 NWLHboo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTFwNkO0OlYh|ryP MVzTRW5ITVJ?
TE-11 Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFwNkO1NlIh|ryP MlzJV2FPT0WU
BHY MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jOcmlEPTB;MT62OVY3OyEQvF2= NYrEU|FrW0GQR1XS
ML-2 MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TzdmlEPTB;MT62OlgxOiEQvF2= M2f4bXNCVkeHUh?=
MEL-JUSO MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfSTJBKSzVyPUGuO|I5QTFizszN MXHTRW5ITVJ?
U251 M2j2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS2bolKSzVyPUGuO|QxOzFizszN NUi5TpA5W0GQR1XS
MHH-ES-1 NGXEbo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrHbYZKSzVyPUGuO|k2PjhizszN MYXTRW5ITVJ?
CAL-85-1 NGO5c2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLofHpKSzVyPUGuPFA1QSEQvF2= NGHyUGxUSU6JRWK=
D-336MG NH7sRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rhSWlEPTB;MT64OVYyPCEQvF2= MXrTRW5ITVJ?
VA-ES-BJ MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\1TWM2OD1zLkmwN|E2KM7:TR?= NGjEUoVUSU6JRWK=
MDA-MB-468 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\mSoJRUUN3ME2xMlkyOjd{IN88US=> M{S1fXNCVkeHUh?=
MEL-HO NUS0R4dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj5WlQ3UUN3ME2xMlk4QTl|IN88US=> NFPDXJNUSU6JRWK=
SW954 M3fW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqxXHpKSzVyPUKuNFAyPTFizszN NIfFcYdUSU6JRWK=
LB831-BLC M1O2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjHTWM2OD1{LkCwPVg5KM7:TR?= M3rERXNCVkeHUh?=
EW-16 M4HlUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vkRmlEPTB;Mj6wN|k5OyEQvF2= MVfTRW5ITVJ?
NCI-H460 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJwMES4N|kh|ryP MnS3V2FPT0WU
CHP-212 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJwMEm1N|kh|ryP NWfESY9uW0GQR1XS
MHH-NB-11 Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfHXotRUUN3ME2yMlEzQDF6IN88US=> MUHTRW5ITVJ?
DU-4475 MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnye4c5UUN3ME2yMlE1PzV7IN88US=> NHXoSYlUSU6JRWK=
ABC-1 MoPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHRTWM2OD1{LkK1NVk3KM7:TR?= MnS5V2FPT0WU
LOUCY NYPlNmYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvQTWM2OD1{LkK2NVI5KM7:TR?= NE\C[lRUSU6JRWK=
LC-2-ad MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrWXWttUUN3ME2yMlI3QTZ4IN88US=> NVfoTG5SW0GQR1XS
ETK-1 MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwMki0OkDPxE1? M17Be3NCVkeHUh?=
KYSE-180 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfXXY1KSzVyPUKuNlg5PzRizszN NX;lW2IyW0GQR1XS
HOP-92 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M322fGlEPTB;Mj6zNFY4OyEQvF2= MVTTRW5ITVJ?
RCC10RGB M1O3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJwM{K1NFch|ryP NIqxTmxUSU6JRWK=
KASUMI-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGyW3JKSzVyPUKuN|I5QCEQvF2= MVTTRW5ITVJ?
ACN NYnBZ2JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXRSZBKSzVyPUKuN|Q4PDVizszN M3HDUnNCVkeHUh?=
BxPC-3 M3LRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHUOIlHUUN3ME2yMlM2PDN4IN88US=> MWHTRW5ITVJ?
MONO-MAC-6 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjaTWM2OD1{LkSxNlQ5KM7:TR?= NHT3N4hUSU6JRWK=
CAL-39 NFfvcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\2TGlEPTB;Mj60NVYzQCEQvF2= NFjnWlZUSU6JRWK=
CMK MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTJwNEG3PVUh|ryP NXTYWFFCW0GQR1XS
MFE-296 M2XC[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvqXVZ{UUN3ME2yMlQ4Pzl{IN88US=> NULRU2x2W0GQR1XS
DU-145 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJwNEmxNVgh|ryP NYT0bFFvW0GQR1XS
MDA-MB-231 M4j1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrmc4ZJUUN3ME2yMlQ6PTd{IN88US=> NFv3Z2NUSU6JRWK=
EFO-27 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DqVGlEPTB;Mj61NVg5QCEQvF2= MVjTRW5ITVJ?
SNU-387 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml72TWM2OD1{LkWyPFIh|ryP M3XnZXNCVkeHUh?=
KYSE-410 NE\QWpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXkcpdKSzVyPUKuOVY2OTdizszN NEDaOWlUSU6JRWK=
NCCIT M{WyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfNSmpKSzVyPUKuOVczPCEQvF2= M{ThXXNCVkeHUh?=
LXF-289 M3LLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HWO2lEPTB;Mj61PFI4OyEQvF2= NFX1OJdUSU6JRWK=
HMV-II NGTHe2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkCzTWM2OD1{LkW4PVk4KM7:TR?= M4XXNXNCVkeHUh?=
MOLT-4 NVrNVGxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDwc21KSzVyPUKuOlA4OTJizszN NVjtdlFtW0GQR1XS
KOSC-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M132UWlEPTB;Mj62N|g4QSEQvF2= Mmq4V2FPT0WU
TUR NWDWWFNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwNkWzOlkh|ryP MlzCV2FPT0WU
NCI-H2087 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HZUWlEPTB;Mj63NVY1PiEQvF2= NFq0S5lUSU6JRWK=
SCC-15 MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnENFJZUUN3ME2yMlc2OjV{IN88US=> M{fORnNCVkeHUh?=
HSC-4 MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;UemlEPTB;Mj63PFM5QSEQvF2= MYrTRW5ITVJ?
G-402 NGHKVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe2N|dKSzVyPUKuPFE1PDdizszN Ml\JV2FPT0WU
GP5d NU\kWYJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzGSZhOUUN3ME2yMlg{QDJ5IN88US=> M2S5W3NCVkeHUh?=
IGR-1 NUWz[oNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJwOEO5PFch|ryP MmP1V2FPT0WU
SK-PN-DW NH7oS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGyfJN7UUN3ME2yMlg3OjB2IN88US=> MVnTRW5ITVJ?
OPM-2 M37lb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXOWXo1UUN3ME2yMlg6QTd6IN88US=> MV;TRW5ITVJ?
5637 NV3GWnViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;tcnVKSzVyPUKuPVI1OzlizszN NViwZnIzW0GQR1XS
NCI-H2030 MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW2TWM2OD1{Lkm4NFI6KM7:TR?= NUP3e|hnW0GQR1XS
SK-LU-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJwOUizN|Qh|ryP MoHWV2FPT0WU
EW-18 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTt[o1TUUN3ME2zMlA2OzJizszN MXPTRW5ITVJ?
786-0 NVHvTXlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHSeJJKSzVyPUOuNFU4QDRizszN M3roRXNCVkeHUh?=
NCI-H1963 NGi1[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q0OWlEPTB;Mz6wPFgzPSEQvF2= Mlu3V2FPT0WU
A2780 NUTIXG9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP5TWM2OD1|LkGwN|QyKM7:TR?= M4HzUXNCVkeHUh?=
NCI-H526 NGi0fYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNwMUO5OlEh|ryP MV3TRW5ITVJ?
BHT-101 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;oTWM2OD1|LkG1O|k5KM7:TR?= NUO5[pl5W0GQR1XS
RPMI-7951 NXrPc|RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\yU4lKSzVyPUOuNlAyOzdizszN NYKwSol{W0GQR1XS
HL-60 NXP2[VFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vY[2lEPTB;Mz6yNVE1KM7:TR?= NEPmPZhUSU6JRWK=
CTV-1 MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC5TWM2OD1|LkK1N|c4KM7:TR?= Mkj4V2FPT0WU
IST-SL1 NVrX[mhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\1OWJKSzVyPUOuNlk1PjVizszN NV;xPYMyW0GQR1XS
G-401 NX7GcWZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;NdmlKSzVyPUOuNlk5ODhizszN MYjTRW5ITVJ?
OVCAR-5 NGHOeWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPVTWM2OD1|LkO2N|UzKM7:TR?= MnLGV2FPT0WU
EW-1 Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTNwNEC1OFQh|ryP NX\PRVJpW0GQR1XS
H4 NH7ad|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37mUGlEPTB;Mz60O|U3QSEQvF2= M4\ifHNCVkeHUh?=
EM-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DqRmlEPTB;Mz60PFY4PCEQvF2= NV7LTYNpW0GQR1XS
RS4-11 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmOxTWM2OD1|LkS4O|E2KM7:TR?= MUTTRW5ITVJ?
NOMO-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m4UmlEPTB;Mz60PVIxPCEQvF2= M3fvT3NCVkeHUh?=
HCT-116 NWXxPWdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTNwNUC3NVEh|ryP M3HmfHNCVkeHUh?=
CAL-120 M{f3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PrbWlEPTB;Mz61O|M2KM7:TR?= M{jhR3NCVkeHUh?=
CAL-51 NWG3VIJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD0TWM2OD1|LkW3OlEzKM7:TR?= NYnQfW1uW0GQR1XS
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NCI-H2081 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjxN2xKSzVyPUOuOlUzQDhizszN MX3TRW5ITVJ?
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ATN-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLyN4ZvUUN3ME20MlExPzd5IN88US=> NX\oTYU5W0GQR1XS
RPMI-2650 M2TicWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDaTWM2OD12LkGyPVc2KM7:TR?= MlzpV2FPT0WU
SIMA NXnXNIF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vRdWlEPTB;ND6xOFQh|ryP MYfTRW5ITVJ?
CA46 MonXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fqTGlEPTB;ND6xOlExPCEQvF2= M3G3OnNCVkeHUh?=
CHL-1 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF72V2lKSzVyPUSuNVg6PjFizszN NELvc29USU6JRWK=
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C8166 MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLXdoJZUUN3ME20MlQ4PzV|IN88US=> NVnDPHhHW0GQR1XS
NCI-H358 NYfHUlI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP3XGlJUUN3ME20MlQ5PTN{IN88US=> M3vQZ3NCVkeHUh?=
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NCI-SNU-1 NWPXZXZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYToTnlrUUN3ME20MlQ6PzBzIN88US=> NIrtbFhUSU6JRWK=
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L-363 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHLboZ[UUN3ME20MlU2QTl4IN88US=> MnXUV2FPT0WU
Calu-1 NIXkTGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvyTXJKSzVyPUSuOVg4ODdizszN NHyxVWNUSU6JRWK=
OE19 M1HWbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTRwNkOxOFUh|ryP NUDvcYNTW0GQR1XS
COR-L23 NVLoSnhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\5OGlEPTB;ND62O|I5KM7:TR?= MVnTRW5ITVJ?
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MKN1 NV25PZdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwN{C2OlUh|ryP MoG5V2FPT0WU
SH-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD12LkeyOlM{KM7:TR?= M4SzNHNCVkeHUh?=
SNB75 MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrtR3ZKSzVyPUSuO|Q3PiEQvF2= M{DC[XNCVkeHUh?=
SW780 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTRwN{[4OFkh|ryP NGjpcHJUSU6JRWK=
GOTO M13m[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfB[3dKSzVyPUSuO|kzQTNizszN NUe0XmR6W0GQR1XS
U-266 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;ufY1KSzVyPUSuPVQ6OTlizszN MkXhV2FPT0WU
KURAMOCHI M3fnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zLNGlEPTB;NT6wNlg{PCEQvF2= MXvTRW5ITVJ?
NMC-G1 NWPVdFN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[zOZBvUUN3ME21MlA6OTN7IN88US=> M4XkN3NCVkeHUh?=
COLO-684 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PyOmlEPTB;NT6yOVM4OSEQvF2= NGHFZnVUSU6JRWK=
NTERA-S-cl-D1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nUdWlEPTB;NT6yPVIyQCEQvF2= M2jiT3NCVkeHUh?=
RD MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr0R4lKSzVyPUWuNlk4PzFizszN NWnzeGY2W0GQR1XS
A2058 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;CTmlEPTB;NT6zNFQ{QCEQvF2= M2\HOHNCVkeHUh?=
NCI-H2009 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3xTWM2OD13LkOwOVM5KM7:TR?= Mn3RV2FPT0WU
8-MG-BA MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTVwM{ewO|ch|ryP NFzHSHpUSU6JRWK=
LC4-1 NYnLSYxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jtb2lEPTB;NT6zPVMxOyEQvF2= NV\mdY51W0GQR1XS
A101D NILDV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Kz[WlEPTB;NT6zPVY5QSEQvF2= NGHZd3NUSU6JRWK=
ES8 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\wO2lEPTB;NT60NVQxQSEQvF2= MV3TRW5ITVJ?
SF126 NFnBXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm1TWM2OD13LkSxOFY2KM7:TR?= NFHJXmRUSU6JRWK=
GDM-1 MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S0WGlEPTB;NT60NVc5OSEQvF2= M4nzZ3NCVkeHUh?=
TE-6 MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTVwNES1Olkh|ryP MlLxV2FPT0WU
SR NUnHZYpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4izT2lEPTB;NT61N|Y1PSEQvF2= M1rXT3NCVkeHUh?=
HOP-62 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12ydmlEPTB;NT61Olg5PyEQvF2= NHfo[WFUSU6JRWK=
HCC2157 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfhTnhKSzVyPUWuOVY5QTZizszN NWTkWmo4W0GQR1XS
TE-15 M1v6b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP2TWM2OD13LkW3O|c6KM7:TR?= MYLTRW5ITVJ?
BFTC-905 M4\zXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTVwNkC0NlEh|ryP M{LhUHNCVkeHUh?=
TE-9 NX\hTIhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:xWWlEPTB;NT62NVc5QCEQvF2= MXPTRW5ITVJ?
647-V MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjYTWM2OD13Lk[yNFQzKM7:TR?= NXzuO3h{W0GQR1XS
KG-1 M1Tjemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTVwN{SwNFUh|ryP MljNV2FPT0WU
KYSE-510 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHDbI5KSzVyPUWuO|k2QDFizszN MoiyV2FPT0WU
SK-MES-1 NGDsWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL0TWM2OD13Lki1PFkyKM7:TR?= MUXTRW5ITVJ?
OVCAR-3 NYXZVYFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTVwOEiyNFYh|ryP Mn;xV2FPT0WU
LB1047-RCC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPXd4I{UUN3ME21MlkxOTR6IN88US=> NIHtfnBUSU6JRWK=
HEL NF7lT25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DsOWlEPTB;Nj6wNlE5QCEQvF2= MoG5V2FPT0WU
KARPAS-45 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLxTWM2OD14LkCzO|g4KM7:TR?= MYfTRW5ITVJ?
NCI-H1304 NHvYV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED6VZVKSzVyPU[uNVI1QTdizszN NGXwXXdUSU6JRWK=
PC-3 MmXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly2TWM2OD14LkGzNFczKM7:TR?= M4rSeHNCVkeHUh?=
Calu-3 NF:yVphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7ZZ3NUUUN3ME22MlE1Pjh7IN88US=> NFjXUo1USU6JRWK=
NCI-H1648 NYPLUINrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTZwMUWxOkDPxE1? M4n5eHNCVkeHUh?=
HSC-3 M4eyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjaeGM1UUN3ME22MlE4Ozl4IN88US=> NF\HZ2NUSU6JRWK=
COLO-824 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmToTWM2OD14LkK3PFY5KM7:TR?= M2HCTXNCVkeHUh?=
COLO-680N MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f0OWlEPTB;Nj6zO|Y{QCEQvF2= NWr3TpY4W0GQR1XS
SK-NEP-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfzbIF6UUN3ME22MlQxOzZizszN NXzXOXRMW0GQR1XS
SCC-25 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTZwNEK0PVMh|ryP Mm\EV2FPT0WU
SF295 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjWNlVZUUN3ME22MlQ1QThizszN NXWzb3JNW0GQR1XS
no-10 MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3weGtGUUN3ME22MlQ4QDRizszN MkLEV2FPT0WU
NCI-H838 M{KwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDPfWhKSzVyPU[uOVE4ODNizszN MnTSV2FPT0WU
M059J M4H6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfIOYZKSzVyPU[uOVU3OjVizszN NI\IO2JUSU6JRWK=
Calu-6 M2DUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\z[GlEPTB;Nj62OVQ{PSEQvF2= M4O0ZXNCVkeHUh?=
TE-12 NF7CXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVThN4NJUUN3ME22MlczOzd5IN88US=> Ml71V2FPT0WU
639-V MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn30TWM2OD14Lke1NVI4KM7:TR?= MojRV2FPT0WU
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C-4-II Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTZwOEOxNVch|ryP NEHDcZdUSU6JRWK=
23132-87 NITBPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[3O2lEPTB;Nj65NFkxOSEQvF2= Ml;KV2FPT0WU
MEG-01 NHrYPG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjYS4tKSzVyPU[uPVM2PDZizszN MUHTRW5ITVJ?
GI-1 M3K3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTZwOUSzOFgh|ryP NHHuPZBUSU6JRWK=
NCI-H2347 NYn1b3hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTh[pRKSzVyPU[uPVQ4OTVizszN MlSyV2FPT0WU
MS-1 MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHTWWdKSzVyPU[uPVUyQTJizszN NFq3V4hUSU6JRWK=
SK-MEL-30 NIHUfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnqTWM2OD14Lkm2N|E2KM7:TR?= NVXlbXh5W0GQR1XS
YKG-1 NYDRdIpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjZOHFKSzVyPUeuNFI3PzhizszN NYC0[48zW0GQR1XS
HT-3 NWD1UoQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ezXWlEPTB;Nz6wN|Q6KM7:TR?= Mn\HV2FPT0WU
NCI-H2126 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;jVphKSzVyPUeuNFk4QTFizszN NW\rVpNyW0GQR1XS
GI-ME-N MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPj[WpTUUN3ME23MlE3QTB4IN88US=> NHnoe5pUSU6JRWK=
LB771-HNC NVzJToNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVWxZlNOUUN3ME23MlE5ODN6IN88US=> NF2zc3BUSU6JRWK=
LCLC-97TM1 M1\YcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mon6TWM2OD15LkKxNlc{KM7:TR?= MVrTRW5ITVJ?
HO-1-N-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjsb2k5UUN3ME23MlI1ODJ2IN88US=> NFPkU2JUSU6JRWK=
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HuO9 M3jRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnzTWM2OD15LkS4O|k1KM7:TR?= MmjVV2FPT0WU
IST-SL2 MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzL[GtKSzVyPUeuOVIzPzJizszN M2\1OHNCVkeHUh?=
MLMA NWTn[49bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnOWox6UUN3ME23MlU1Pjh7IN88US=> M4m4XnNCVkeHUh?=
22RV1 M2G2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C1eWlEPTB;Nz62O|k4PSEQvF2= MYrTRW5ITVJ?
ONS-76 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HoeGlEPTB;Nz62PVQyPiEQvF2= Mn23V2FPT0WU
ECC12 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTdwN{K5NFEh|ryP NHi4dmhUSU6JRWK=
HT-1080 M2T1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\zTWM2OD15Lke4OVU2KM7:TR?= MXTTRW5ITVJ?
SF268 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjUZYRKSzVyPUeuPFM2PiEQvF2= NVjFWGE4W0GQR1XS
COLO-800 NHPmXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj0bYo1UUN3ME23MlkxPjh3IN88US=> MVjTRW5ITVJ?
BB30-HNC NFqyNFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfMdY4zUUN3ME23Mlk1PTV|IN88US=> M{noVnNCVkeHUh?=
CAKI-1 NVzKUFRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mzUWlEPTB;OD6wOlUzOSEQvF2= MnLxV2FPT0WU
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U031 M4XUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF7LkKyNVkh|ryP MWnTRW5ITVJ?
NCI-H524 NGjnNVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO3TWM2OD1zOT61O|I2KM7:TR?= Mln6V2FPT0WU
KU812 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\pNGlEPTB;MUmuOVk1PCEQvF2= M4rifnNCVkeHUh?=
NB10 NGnGXY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTF7Lk[yOlgh|ryP MnyxV2FPT0WU
NOS-1 MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF63XZdKSzVyPUKwMlE2PzdizszN MUjTRW5ITVJ?
EW-7 NFLkXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOy[m9KSzVyPUKwMlE3OjhizszN NHyzeWlUSU6JRWK=
Raji MmDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTETWM2OD1{MD6yOVY5KM7:TR?= NHfBZ4JUSU6JRWK=
LB2518-MEL NHHHbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzBTWM2OD1{MD6zPVU{KM7:TR?= MnnlV2FPT0WU
PANC-10-05 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInCOpNKSzVyPUKwMlQ3OTNizszN NVvFUVBwW0GQR1XS
MZ2-MEL NE\hfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnOd3lUUUN3ME2yNE42QDF2IN88US=> NWLtUmE3W0GQR1XS
MFE-280 NFrOT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjCSJcxUUN3ME2yNU4{OTh6IN88US=> NXewXYpJW0GQR1XS
RKO NHfJWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJzLkOyNFIh|ryP MXTTRW5ITVJ?
KMOE-2 MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofaTWM2OD1{MT6zNlg5KM7:TR?= Mn25V2FPT0WU
K5 NGDWTpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q1UWlEPTB;MkGuN|g6OyEQvF2= M2rOWXNCVkeHUh?=
NCI-H64 MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVewRnFMUUN3ME2yNU41PzV4IN88US=> MkPhV2FPT0WU
K-562 M3HWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnPS|VxUUN3ME2yNU41QTdzIN88US=> NX3ndHJiW0GQR1XS
HCE-T MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vqW2lEPTB;MkGuOVA6PCEQvF2= MY\TRW5ITVJ?
COLO-792 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv5TWM2OD1{MT61PFI4KM7:TR?= NXrrR|ZWW0GQR1XS
PFSK-1 NI[zZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJzLk[4N|ch|ryP NIDXcGRUSU6JRWK=
DOK NIe5SlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJzLke2PFch|ryP Ml\2V2FPT0WU
NCI-H1882 NEHw[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zWZ2lEPTB;MkGuPFU6PiEQvF2= M4rYdXNCVkeHUh?=
KNS-81-FD NFXnWlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLtZVhLUUN3ME2yNU45PjNzIN88US=> NULRdZBHW0GQR1XS
OCUB-M M{TCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPuWmp2UUN3ME2yNU46Pjh6IN88US=> Mlq0V2FPT0WU
NCI-H1694 NH60VndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW5TWM2OD1{MT65PFY{KM7:TR?= Mlu5V2FPT0WU
LS-513 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17uO2lEPTB;MkKuNFM3PyEQvF2= MYTTRW5ITVJ?
NCI-H2122 NEX1OJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonJTWM2OD1{Mj6xOlc4KM7:TR?= NXrmdHRyW0GQR1XS
IMR-5 NYfKeHRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OxemlEPTB;MkKuNlg4KM7:TR?= M4X2dHNCVkeHUh?=
SNU-C2B M4PXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v3[mlEPTB;MkKuOlc1PiEQvF2= MV\TRW5ITVJ?
A498 NEX3ZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;qd2NKSzVyPUKyMlgyPzdizszN MoPaV2FPT0WU
NCI-H727 NHLmU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDZ[ZFnUUN3ME2yNk45QDN4IN88US=> Ml;4V2FPT0WU
SW1573 NEm3dIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLSTWM2OD1{Mz6wOlQ3KM7:TR?= NUTLbJM5W0GQR1XS
RO82-W-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TUfmlEPTB;MkOuNlUyOSEQvF2= NVyyR5Z7W0GQR1XS
SKG-IIIa NWnPcFd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJ|LkO1OFYh|ryP MWrTRW5ITVJ?
MC-CAR MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJ|LkWxPFMh|ryP NWXOVFRIW0GQR1XS
NCI-H446 NYTGNG1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJ|Lk[wPVMh|ryP MoL5V2FPT0WU
PC-14 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DzemlEPTB;MkOuOlYzOyEQvF2= M1nYOXNCVkeHUh?=
TGBC1TKB MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[2eGNKSzVyPUKzMlc1PjFizszN NXPDN|JIW0GQR1XS
EFM-19 NFLTflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi3RmVKSzVyPUK0MlE5PDRizszN Mly2V2FPT0WU
SK-N-DZ M2PmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3OZYxKSzVyPUK0MlQ6PzdizszN MWjTRW5ITVJ?
NCI-H661 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D0UmlEPTB;MkSuOVIyPyEQvF2= M3;leXNCVkeHUh?=
SW1990 NIHleFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfoNVVKSzVyPUK0MlU5QDNizszN NGW4Z5ZUSU6JRWK=
SW684 NG[5c4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJ2Lke2NlQh|ryP MoHVV2FPT0WU
Ca-Ski M4ToeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\mTWM2OD1{ND65NlM4KM7:TR?= NIDJbGZUSU6JRWK=
TGW NFTFPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fWUmlEPTB;MkWuNlM{PyEQvF2= MYnTRW5ITVJ?
CaR-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[5Z2lEPTB;MkWuN|U4KM7:TR?= M3LIV3NCVkeHUh?=
D-247MG NYrFb5dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknLTWM2OD1{NT60O|Q{KM7:TR?= NF6ySG1USU6JRWK=
CCRF-CEM MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTzTWM2OD1{NT63OFU6KM7:TR?= MkHaV2FPT0WU
CAPAN-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[zWFA5UUN3ME2yOU44PTBzIN88US=> M4noWXNCVkeHUh?=
CP50-MEL-B NIGyN3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vESGlEPTB;MkWuPVkxOSEQvF2= M1PafXNCVkeHUh?=
FADU NFTWWGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJ4LkWxOVIh|ryP MVnTRW5ITVJ?
Daudi NGDxXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULwNmlFUUN3ME2yOk42OTV6IN88US=> NYLLc2VIW0GQR1XS
U-87-MG NYDJRWJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3vUGdGUUN3ME2yOk42OzB3IN88US=> M1n1SXNCVkeHUh?=
DSH1 NHjPW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP4XHp7UUN3ME2yOk42PDB4IN88US=> NVrofHY6W0GQR1XS
KYSE-520 M4K0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL1bW1KSzVyPUK2MlU2PTNizszN NX\CdGhEW0GQR1XS
HuH-7 NX[0XoxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJ4LkmwPFYh|ryP M{\hc3NCVkeHUh?=
U-2-OS NFPIcFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7nTWM2OD1{Nz6wNlcyKM7:TR?= NXfkRXNyW0GQR1XS
LU-99A MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJ5LkG3OVQh|ryP Mkm2V2FPT0WU
T98G NU\WWGRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ5LkG5O|Mh|ryP NUfjUVdOW0GQR1XS
MZ7-mel NH7YOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPMVFhWUUN3ME2yO{42PTR6IN88US=> MlLYV2FPT0WU
SNU-C1 NX7Me2dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\jSppKSzVyPUK3MlY1QTFizszN NGqzcmxUSU6JRWK=
MDA-MB-175-VII NI\qOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M124[2lEPTB;MkeuOlk4PSEQvF2= MlzlV2FPT0WU
HuP-T3 NX7CdpVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzyTWM2OD1{OD6wOFk2KM7:TR?= NXHVNIQ2W0GQR1XS
T-24 NIDh[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTa[3RmUUN3ME2yPE4yQTJ3IN88US=> MmmzV2FPT0WU
HDLM-2 M{W3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH71U5pKSzVyPUK4MlI1PTlizszN MkDoV2FPT0WU
NCI-H1651 M4rCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq3bGxKSzVyPUK4MlI2QTJizszN M3XjbHNCVkeHUh?=
SK-N-AS MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJ6LkOxO|Eh|ryP NHTvWIVUSU6JRWK=
NY Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LQXWlEPTB;MkiuOlU4QSEQvF2= NWTDXHBUW0GQR1XS
D-283MED MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJ6Lki3NFgh|ryP NIW5dIJUSU6JRWK=
KLE MmjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJ6Lkm5NFYh|ryP NXmxSIJ5W0GQR1XS
NCI-H28 NYr4V|hiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTETWM2OD1{OT6wNVIh|ryP MnzCV2FPT0WU
TE-1 MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETBS4lKSzVyPUK5MlIyPjdizszN Mn\OV2FPT0WU
SK-MEL-24 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJ7LkW0OlYh|ryP MYTTRW5ITVJ?
CAL-54 MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XLemlEPTB;MkmuOlA1PiEQvF2= NXrx[2RwW0GQR1XS
A673 Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvhbXpKSzVyPUK5Mlc{OiEQvF2= MnjLV2FPT0WU
HEC-1 NUXHPZJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rBW2lEPTB;M{CuNFA2OyEQvF2= M4X2ZXNCVkeHUh?=
LS-411N MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTNyLkG0O|Uh|ryP NHHyfnRUSU6JRWK=
SW962 NHT6[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzRS5hjUUN3ME2zNE4zPDd5IN88US=> MkWyV2FPT0WU
OVCAR-8 M{TpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1KxN2lEPTB;M{CuOlc6PCEQvF2= NFHubY5USU6JRWK=
NCI-H630 M3vUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofBTWM2OD1|MD64PVU{KM7:TR?= MUfTRW5ITVJ?
D-263MG NHKyeoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTpToR1UUN3ME2zNU4xPDJ2IN88US=> NGm3fVVUSU6JRWK=
NCI-H596 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjjWmNKSzVyPUOxMlA3OjFizszN M3q4cnNCVkeHUh?=
BB49-HNC NUCydXRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTETWM2OD1|MT6xNVIh|ryP NVHCdJFlW0GQR1XS
KYSE-70 NEH3dJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XKNWlEPTB;M{GuN|AxQCEQvF2= M1PnR3NCVkeHUh?=
LAN-6 NITIeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\WXGFJUUN3ME2zNU41QTl{IN88US=> NYfxZXJrW0GQR1XS
NCI-H2228 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDzTWM2OD1|MT61OlI2KM7:TR?= MWfTRW5ITVJ?
SW620 M17qVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\nfmlEPTB;M{GuOlI5OyEQvF2= M{HLV3NCVkeHUh?=
KM-H2 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\jbmlEPTB;M{GuO|MxPiEQvF2= NHjJOI9USU6JRWK=
DJM-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn1TWM2OD1|Mj6xN|g3KM7:TR?= NIXncIJUSU6JRWK=
SW48 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fSRWlEPTB;M{KuN|gzPSEQvF2= MWrTRW5ITVJ?
NCI-H1793 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT6TWM2OD1|Mj62NVY{KM7:TR?= MWPTRW5ITVJ?
LU-165 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPFdnlRUUN3ME2zN{4xODhizszN NVTkZlZsW0GQR1XS
EHEB MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPaRYVKSzVyPUOzMlA1QTRizszN NYHGS5ZbW0GQR1XS
NCI-H441 Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN|LkKyN|Uh|ryP NVO3fmlHW0GQR1XS
LOXIMVI NITKTVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TFd2lEPTB;M{OuN|Y4QSEQvF2= NHvXV5BUSU6JRWK=
MC-IXC MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm1RY1KSzVyPUOzMlU3PTVizszN MoK3V2FPT0WU
NCI-H522 M4njfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTN|Lk[1OEDPxE1? NXvZUnNOW0GQR1XS
IA-LM MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTN|Lk[3OFYh|ryP MlfyV2FPT0WU
NCI-H1417 NHS2WJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\ZR5pKSzVyPUOzMlk2QDVizszN NYT4OFdDW0GQR1XS
HCC2218 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W2OmlEPTB;M{WuNlE5PSEQvF2= NEjROlNUSU6JRWK=
HC-1 NFy3V5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\WXmlEPTB;M{WuOFAzPCEQvF2= NUHkPI9JW0GQR1XS
HH NH21bGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuzVWVKSzVyPUO1MlQyPDFizszN MX3TRW5ITVJ?
EFE-184 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW4TWM2OD1|NT62PFI6KM7:TR?= NEnDXoZUSU6JRWK=
NCI-H1355 NXP2[pR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LL[WlEPTB;M{WuO|cyQCEQvF2= M3LucnNCVkeHUh?=
BV-173 NVzrPVlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInEWmRKSzVyPUO1MlgzPjRizszN NVjUSFlyW0GQR1XS
NEC8 NUTm[mhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTN4LkS5NlQh|ryP MlnxV2FPT0WU
SW1463 NWH5OJB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLQSYw{UUN3ME2zOk43PTZ4IN88US=> M3rvVHNCVkeHUh?=
KYSE-140 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\BNGlEPTB;M{[uO|I6QCEQvF2= MkLFV2FPT0WU
no-11 MkXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzjTWM2OD1|Nj64OVM3KM7:TR?= MYXTRW5ITVJ?
HCC1937 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN5LkCxOVQh|ryP MYLTRW5ITVJ?
LNCaP-Clone-FGC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjZXohKSzVyPUO3MlE6ODNizszN MWfTRW5ITVJ?
KARPAS-422 Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO3O4hsUUN3ME2zO{41PDNzIN88US=> MnrkV2FPT0WU
RCM-1 NGn6bW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHZ[VRKSzVyPUO3MlU{PThizszN NVzwbZpCW0GQR1XS
A375 M4j0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXkS5NKSzVyPUO3Mlc3PDdizszN MXnTRW5ITVJ?
TGBC24TKB NFLlfVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;KfotGUUN3ME2zPE4xOjN7IN88US=> M{LS[XNCVkeHUh?=
MDA-MB-453 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T1OmlEPTB;M{muNFIyQCEQvF2= NYO5T5BbW0GQR1XS
Capan-2 NYjMNXVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjsbYZKSzVyPUO5MlA2ODlizszN NYS1XYRWW0GQR1XS
SW756 NFv0[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIi0OnFKSzVyPUO5MlUxQTFizszN NHLvfYtUSU6JRWK=
KU-19-19 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfoV5FNUUN3ME2zPU43Ojh{IN88US=> NHr5UJJUSU6JRWK=
NCI-H2170 NFXSRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTN7Lkm5O|ch|ryP Mk\YV2FPT0WU
COLO-678 NUHZZ4tuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTRyLkW5OUDPxE1? M3zIbnNCVkeHUh?=
PF-382 NISzfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTRyLke0PFch|ryP MXTTRW5ITVJ?
OAW-42 NIjZcmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPwfFdKSzVyPUSyMlI6PDJizszN MlHVV2FPT0WU
LB996-RCC Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTv[28zUUN3ME20Nk45ODB6IN88US=> MkHFV2FPT0WU
SAS Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXLSWNKSzVyPUSzMlQzQDhizszN NVnicFRpW0GQR1XS
MRK-nu-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTR2Lke0NVQh|ryP MXTTRW5ITVJ?
EoL-1-cell NYjydFZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTR2LkmxN|Yh|ryP NGjLdGtUSU6JRWK=
NCI-H2342 M1nmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjxOGU3UUN3ME20OU4yOTF5IN88US=> MVXTRW5ITVJ?
NCI-H1703 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjKTWM2OD12Nj6wOVkzKM7:TR?= M2\ZNXNCVkeHUh?=
NCI-H187 NEC0U3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi1eFFKSzVyPUS2MlE5PjlizszN NWrESFVkW0GQR1XS
CP66-MEL NI\tXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL5RXBJUUN3ME20Ok4zPzh7IN88US=> NELNfYNUSU6JRWK=
HCC1569 NWnw[od2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrXSmttUUN3ME20Ok42QTF5IN88US=> M1nzNXNCVkeHUh?=
BL-70 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTR4Lke3N|ch|ryP NUS2W5BEW0GQR1XS
Saos-2 MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXLW5ZpUUN3ME20O{4{OTJ|IN88US=> NXLScpN5W0GQR1XS
LC-1F M33ncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFOyT|ZKSzVyPUS3MlYyODVizszN NXXGepJMW0GQR1XS
KY821 NUn3T2prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;K[GtKSzVyPUS3MlY1OzRizszN NVnkcYhzW0GQR1XS
PSN1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nvVmlEPTB;NEiuNVQxOSEQvF2= MlfCV2FPT0WU
RT4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHOTWM2OD12OD64N|c4KM7:TR?= NGL4enNUSU6JRWK=
LS-1034 Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnzPHNKSzVyPUS4Mlg6PTRizszN NHPGOpVUSU6JRWK=
NCI-H1395 M4HyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLPWI9GUUN3ME20PU4xPDl{IN88US=> MX3TRW5ITVJ?
EKVX NFO1Ro9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X5bWlEPTB;NEmuOlc{OSEQvF2= Ml\TV2FPT0WU
IST-MES1 NVTwc3BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KzbGlEPTB;NEmuPFk1PCEQvF2= NIC3ZXpUSU6JRWK=

... Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot
p-FAK / FAK / p-Talin / Talin ; 

PubMed: 26530902     


Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells.

p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; 

PubMed: 29417941     


MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.

26530902 29417941
Immunofluorescence
p-FAK; 

PubMed: 26530902     


Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).

26530902
Growth inhibition assay
Cell viability; 

PubMed: 28953264     


MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk (*) and p < 0.01 are designated by two asterisks (**).

28953264
体内研究 在携带U87MG的小鼠中PF-562271 (< 33 mg/kg 口服)抑制肿瘤中FAK磷酸化并具有时间和剂量依赖特性。PF-562271 (50 mg/kg, 口服，一天两次)对BxPc3异种移植小鼠中肿瘤生长抑制率为86% ，对PC3-M异种移植小鼠中肿瘤生长抑制率为45%。PF-562271 (25mg/kg, 一天两次)处理的携带H125肺部异种移植肿瘤凋亡率提高2倍[1]。 PF-562271 (33 mg/kg,口服)24小时后抑制小鼠中肿瘤细胞的广泛运动。PF-562271 (33 mg/kg, 口服)导致小鼠中E-cadherin动力学的改变，这与减弱的E-cadherin依赖的整体细胞运动有关 [3]。在皮下局部异种移植PC3M-luc-C6的小鼠模型中 PF-562271 (25 mg/kg, 口服，一天两次)导致肿瘤生长率62%的抑制[4]。在胫骨植入MDA-MB-231细胞的大鼠中PF-562271 (5mg/kg, 口服)导致骨钙素和松质骨参数显著而相似的增加同时导致肿瘤生长速度和骨愈合信号的下降[5]。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验：[1]
- 合并
  • Animal Models: 携带BxPc3或 PC3-M异种移植的无胸腺雌性小鼠
  • Dosages: 50 mg/kg
  • Administration: 填喂给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
 5 mg/ml

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 507.49
化学式

C21H20F3N7O3S
CAS号 717907-75-0
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量 只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项
Selleck产品目录册

FAK Signaling Pathway Map

相关FAK产品

  • PND-1186 (VS-4718) New

    PND-1186 (VS-4718)是一种可逆的选择性FAK抑制剂，IC50为1.5 nM。PND-1186 可选择性地促进肿瘤细胞的凋亡。Phase 1。

  • PF-431396 New

    PF-431396是双PYK2/FAK抑制剂，IC50分别为11nM和2 nM。

  • Defactinib (VS-6063) New

    Defactinib (VS-6063, PF-04554878)是一种选择性，且口服有效的FAK抑制剂。Phase 2。

  • PF-00562271 Besylate

    PF-00562271 Besylate是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK效果低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。Phase 1。

  • TAE226 (NVP-TAE226)

    TAE226 (NVP-TAE226) 是一种有效的FAK抑制剂，IC50为5.5 nM，最有效作用于Pyk2，对InsR， IGF-1R， ALK和c-Met作用效果比其弱10到100倍左右。TAE226 (NVP-TAE226) 可诱导凋亡。

  • PF-573228

    PF-573228 是一种ATP竞争性的FAK抑制剂，无细胞试验中IC50为4 nM，作用于FAK比作用于Pyk2，CDK1/7 和 GSK-3β选择性高~50到250倍。PF-573228 可诱导凋亡。

  • PF-562271 HCl

    PF-562271 HCl是PF-562271的盐酸盐形式，是一种强效的ATP竞争性的可逆的抑制剂，作用于FAK其IC50为1.5 nM。相比较FAK，对Pyk2的效果少了大约十倍，除了CDKs类的蛋白酶，PF-562271 HCl的选择性相比其他蛋白酶大大约100倍。

  • Ibrutinib (PCI-32765)

    Ibrutinib (PCI-32765)是一种有效的，高选择性的Brutons tyrosine kinase (Btk)抑制剂，无细胞试验中IC50为0.5 nM，对Bmx， CSK， FGR， BRK及HCK适度有效，对EGFR， Yes， ErbB2， JAK3等作用效果较弱。Ibrutinib 可作为Btk配体用于合成包括P13I在内的一系列PROTAC。

  • Dasatinib

    Dasatinib 是一种新型有效的多靶点抑制剂，作用于Abl、Src和 c-Kit，在无细胞试验中IC50分别为 <1 nM、0.8 nM 和 79 nM。Dasatinib 可诱导自噬和凋亡并具有抗肿瘤的活性。

  • Saracatinib (AZD0530)

    Saracatinib (AZD0530)是一种有效的Src抑制剂，无细胞试验中IC50为2.7 nM，对c-Yes， Fyn， Lyn， Blk， Fgr和Lck也具有活性；但对Abl和EGFR (L858R和L861Q)活性较低。Saracatinib可诱导自噬。Phase 2/3。

    Features:Saracatinib是第一个作用于人类肿瘤组织Src通路的抑制剂。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID