PF-562271

目录号：S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，无细胞试验中IC50为1.5 nM，作用于FAK比作用于Pyk2选择性高10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。

规格 价格 库存 购买数量  
RMB 2862.96 现货
RMB 1392.84 现货
RMB 2194.82 现货
RMB 5469.68 现货
RMB 7967.47 现货
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客户购买Selleck的此次产品后发表的文献12篇：

客户使用该产品的6个实验数据：

  • Effect of matrix stiffness on the susceptibility of primary HDFs to apoptosis induced by inhibition of mechanotransduction pathways. HDFs (primary human dermal fibroblasts) were cultured on collagen-coated polyacrylamide hydrogels that recapitulated the stiffness of normal (4 kPa) or densely fibrotic (50 kPa) skin for 24 hours and treated with or without the agents indicated for an additional 48 hours. Apoptosis was assessed by annexin V staining. Data are means ± SD from three independent experiments. P value was determined by Student’s t test.

    Science, 2017, 9(420), doi: 10.1126/scitranslmed.aal3765. PF-562271 purchased from Selleck.

    (F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

    Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.

  • D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

    Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

    Acta Pharmacol Sin, 2018, doi:10.1038/aps.2017.189. PF-562271 purchased from Selleck.

  • VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

    Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

    OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

    PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

产品安全说明书

FAK抑制剂选择性比较

生物活性

产品描述 PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，无细胞试验中IC50为1.5 nM，作用于FAK比作用于Pyk2选择性高10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。
靶点
FAK [1]
(Cell-free assay)		 PYK2 [1]
(Cell-free assay)		 CDK2/CyclinE [1]
(Cell-free assay)		 CDK3/CyclinE [1]
(Cell-free assay)		 CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
体外研究

PF-562271会结合到ATP与FAK结合的部位,在激酶铰链区形成抑制剂与主链原子之间的两种氢键。PF-562271在测量FAK磷酸化可诱导的基于细胞的分析中效果很好，IC50为5 nM。PF-562271 (3.3 μM)导致PC3-M细胞周期停滞在G1期[1]。在鸡胚绒毛尿囊膜实验中PF-562271 (1nM)阻断bFGF刺激的血管生成。 PF-262271 强有效的阻断血管生长但对血管渗漏没有明显影响[2]。PF-562271 (250 nM)可以完全抑制整体A431 细胞侵入胶原蛋白中[3]。
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 NUX1WGdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjIXHRKSzVyPUCuNlc3PiEQvF2= M4e2fHNCVkeHUh?=
SW982 NEnabIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDpTWM2OD1yLkOyPFIh|ryP NV\yPGJ3W0GQR1XS
KM12 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH1PXNKSzVyPUCuN|g2PTdizszN NUS4coxDW0GQR1XS
COLO-205 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\zTWM2OD1yLkS4OlU5KM7:TR?= NILmdI5USU6JRWK=
COLO-829 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S1R2lEPTB;MD63OVE4PiEQvF2= NYP3bnhLW0GQR1XS
MG-63 NImx[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnflTWM2OD1yLkiwOlM4KM7:TR?= MnnIV2FPT0WU
IGROV-1 NGrqXIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;qXmlEPTB;MD64NVA{QCEQvF2= NEfWOIRUSU6JRWK=
NCI-H650 NVzXWpBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwOEOxOVQh|ryP MYDTRW5ITVJ?
RT-112 NVWyT4hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jONWlEPTB;MD65PFQ3KM7:TR?= NWDKTHJNW0GQR1XS
BCPAP M17zbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFwMEGyPFgh|ryP NEC2Z4FUSU6JRWK=
ALL-PO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\JTWM2OD1zLkCxOVg1KM7:TR?= MXPTRW5ITVJ?
KYSE-270 NVvJdJNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFwMES3NVQh|ryP MnH1V2FPT0WU
8305C MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT0TWM2OD1zLkC5PVA1KM7:TR?= M{DnTHNCVkeHUh?=
NCI-H810 NELafW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvXdmZoUUN3ME2xMlExPzd4IN88US=> MWjTRW5ITVJ?
CAL-33 NIH3TINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzvTWJKSzVyPUGuNVI6OzhizszN M1TTUnNCVkeHUh?=
AN3-CA MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLYTWM2OD1zLkKxPFY4KM7:TR?= NYDEUGJVW0GQR1XS
NKM-1 NYC2ZmtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFwMke1NFYh|ryP M1u0U3NCVkeHUh?=
BPH-1 M4rlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq2SZpVUUN3ME2xMlI5PzZ4IN88US=> MUXTRW5ITVJ?
MES-SA MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;PTWM2OD1zLkOwOlgzKM7:TR?= Mn\0V2FPT0WU
CAL-62 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwM{G5NFkh|ryP M{DYTXNCVkeHUh?=
Detroit562 M33MTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFwM{WyNlIh|ryP M{LMT3NCVkeHUh?=
KYSE-150 NW\0Rm13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnTOYN7UUN3ME2xMlM2OjN4IN88US=> NV;VSZZbW0GQR1XS
SK-UT-1 NGHCXFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnkTWM2OD1zLkS0OlQ4KM7:TR?= MUXTRW5ITVJ?
HUTU-80 M2fUfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrzNHlKSzVyPUGuOFQ5QDZizszN MV;TRW5ITVJ?
SIG-M5 NGfkd|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwNEizPFch|ryP M{XJTXNCVkeHUh?=
AGS M1\MSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLuVpN5UUN3ME2xMlUzOTJ2IN88US=> M1;afnNCVkeHUh?=
ST486 NIn3TWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPHbXFIUUN3ME2xMlU{Ojd6IN88US=> M2m0b3NCVkeHUh?=
HSC-2 NU\oNmdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV74RWhFUUN3ME2xMlU{QTVizszN MkKxV2FPT0WU
LCLC-103H M2fWZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:ySoNoUUN3ME2xMlU2QDF6IN88US=> Ml3NV2FPT0WU
BC-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PhdWlEPTB;MT62NVY3PCEQvF2= MmjiV2FPT0WU
CGTH-W-1 M2O3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES5NY9KSzVyPUGuOlE3PzlizszN NFroTmlUSU6JRWK=
MZ1-PC MoCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz0TWM2OD1zLk[yN|EzKM7:TR?= NITaOotUSU6JRWK=
SW1710 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlftTWM2OD1zLk[yOlI5KM7:TR?= MYnTRW5ITVJ?
EW-13 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3xTWM2OD1zLk[zOFY3KM7:TR?= Mlq5V2FPT0WU
TE-11 M4rn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFwNkO1NlIh|ryP MYDTRW5ITVJ?
BHY NEXhdFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnKTWM2OD1zLk[1OlY{KM7:TR?= MX\TRW5ITVJ?
ML-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnVfFNHUUN3ME2xMlY3QDB{IN88US=> M4faWXNCVkeHUh?=
MEL-JUSO MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnRTHBKSzVyPUGuO|I5QTFizszN NInPVXRUSU6JRWK=
U251 NHL3V|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTFwN{SwN|Eh|ryP Mo\6V2FPT0WU
MHH-ES-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXDTWM2OD1zLke5OVY5KM7:TR?= MWrTRW5ITVJ?
CAL-85-1 Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTFwOEC0PUDPxE1? MWHTRW5ITVJ?
D-336MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjLe2FKSzVyPUGuPFU3OTRizszN M{TycHNCVkeHUh?=
VA-ES-BJ M1PsT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfxc3RKSzVyPUGuPVA{OTVizszN MWLTRW5ITVJ?
MDA-MB-468 NITodYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwOUGyO|Ih|ryP NWDiSVkyW0GQR1XS
MEL-HO M3fOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PRNWlEPTB;MT65O|k6OyEQvF2= Mn7rV2FPT0WU
SW954 M1n2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LaVGlEPTB;Mj6wNFE2OSEQvF2= MY\TRW5ITVJ?
LB831-BLC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqxb4dKSzVyPUKuNFA6QDhizszN MXjTRW5ITVJ?
EW-16 NEHvWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3sTWM2OD1{LkCzPVg{KM7:TR?= M1r3V3NCVkeHUh?=
NCI-H460 MlnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1riSmlEPTB;Mj6wOFg{QSEQvF2= MmPIV2FPT0WU
CHP-212 M3HVZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\qTWM2OD1{LkC5OVM6KM7:TR?= MojZV2FPT0WU
MHH-NB-11 NF;BXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2mx[mlEPTB;Mj6xNlgyQCEQvF2= NEDVWJdUSU6JRWK=
DU-4475 M3nNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJwMUS3OVkh|ryP NFO2TFNUSU6JRWK=
ABC-1 NFnzVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljxTWM2OD1{LkK1NVk3KM7:TR?= NEP5dYJUSU6JRWK=
LOUCY NYnSdGs1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzQTWM2OD1{LkK2NVI5KM7:TR?= NEPMPWhUSU6JRWK=
LC-2-ad NWXUV2w3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvoTWM2OD1{LkK2PVY3KM7:TR?= Mmn2V2FPT0WU
ETK-1 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnDeY44UUN3ME2yMlI5PDZizszN NFfR[ZJUSU6JRWK=
KYSE-180 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzWTWM2OD1{LkK4PFc1KM7:TR?= MmLpV2FPT0WU
HOP-92 M{jNWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXTbWZKSzVyPUKuN|A3PzNizszN Mn:0V2FPT0WU
RCC10RGB M2T4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLCTWM2OD1{LkOyOVA4KM7:TR?= NX;5OI15W0GQR1XS
KASUMI-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwM{K4PEDPxE1? MlT4V2FPT0WU
ACN MkfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrVTWM2OD1{LkO0O|Q2KM7:TR?= M1TobnNCVkeHUh?=
BxPC-3 NYXheHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrwbHFFUUN3ME2yMlM2PDN4IN88US=> MnvaV2FPT0WU
MONO-MAC-6 M2PpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzIbFRKSzVyPUKuOFEzPDhizszN MYDTRW5ITVJ?
CAL-39 NWn5e4xYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTITWM2OD1{LkSxOlI5KM7:TR?= NIrITldUSU6JRWK=
CMK NHi4fHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;nWFlKSzVyPUKuOFE4QTVizszN M{DjSXNCVkeHUh?=
MFE-296 NIr1Ro1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwNEe3PVIh|ryP NEfNTWJUSU6JRWK=
DU-145 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfOXWlKSzVyPUKuOFkyOThizszN MWjTRW5ITVJ?
MDA-MB-231 NH7MNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJwNEm1O|Ih|ryP NWnTcmpXW0GQR1XS
EFO-27 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TUSGlEPTB;Mj61NVg5QCEQvF2= NEHnTmlUSU6JRWK=
SNU-387 NFS0OY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33rW2lEPTB;Mj61NlgzKM7:TR?= NV7yN4FJW0GQR1XS
KYSE-410 M{CzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;UfZRKSzVyPUKuOVY2OTdizszN NV3tTXdIW0GQR1XS
NCCIT M1TMcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX3dolKSzVyPUKuOVczPCEQvF2= MkPLV2FPT0WU
LXF-289 M4nsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTnTWM2OD1{LkW4Nlc{KM7:TR?= MUjTRW5ITVJ?
HMV-II MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLZXoNoUUN3ME2yMlU5QTl5IN88US=> MY\TRW5ITVJ?
MOLT-4 NHHsU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvGZWZKSzVyPUKuOlA4OTJizszN MXLTRW5ITVJ?
KOSC-2 M1vid2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37SRWlEPTB;Mj62N|g4QSEQvF2= MV7TRW5ITVJ?
TUR M3Txd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DabWlEPTB;Mj62OVM3QSEQvF2= NW\qZng{W0GQR1XS
NCI-H2087 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfsXGlKSzVyPUKuO|E3PDZizszN Mli5V2FPT0WU
SCC-15 M1XQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTjRVNPUUN3ME2yMlc2OjV{IN88US=> MXjTRW5ITVJ?
HSC-4 M1\HPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTme4ZTUUN3ME2yMlc5Ozh7IN88US=> NY\P[YdZW0GQR1XS
G-402 NXvhR3Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz4d|lGUUN3ME2yMlgyPDR5IN88US=> M1;DR3NCVkeHUh?=
GP5d MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln5TWM2OD1{LkizPFI4KM7:TR?= MnLGV2FPT0WU
IGR-1 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nifmlEPTB;Mj64N|k5PyEQvF2= MWTTRW5ITVJ?
SK-PN-DW MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHJTWM2OD1{Lki2NlA1KM7:TR?= NX\qWoNIW0GQR1XS
OPM-2 M1Hremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37D[mlEPTB;Mj64PVk4QCEQvF2= MlHvV2FPT0WU
5637 NGTjZ5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfkWmpNUUN3ME2yMlkzPDN7IN88US=> NVrM[3MxW0GQR1XS
NCI-H2030 NEfwVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni1TWM2OD1{Lkm4NFI6KM7:TR?= NXvvNZdzW0GQR1XS
SK-LU-1 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G5eWlEPTB;Mj65PFM{PCEQvF2= NGPUcW5USU6JRWK=
EW-18 NIPne5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvUPGJ2UUN3ME2zMlA2OzJizszN NXHtRYFGW0GQR1XS
786-0 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorpTWM2OD1|LkC1O|g1KM7:TR?= MlTEV2FPT0WU
NCI-H1963 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HM[WlEPTB;Mz6wPFgzPSEQvF2= M3nKZnNCVkeHUh?=
A2780 M4rjNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfh[41XUUN3ME2zMlExOzRzIN88US=> MlnmV2FPT0WU
NCI-H526 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PiUWlEPTB;Mz6xN|k3OSEQvF2= M1zndXNCVkeHUh?=
BHT-101 M{PVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLiTWM2OD1|LkG1O|k5KM7:TR?= NVvjdowxW0GQR1XS
RPMI-7951 NVz6OIpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXkTWM2OD1|LkKwNVM4KM7:TR?= Mk[4V2FPT0WU
HL-60 MkC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7Hdoh1UUN3ME2zMlIyOTRizszN M{DkNnNCVkeHUh?=
CTV-1 MnTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXSTWM2OD1|LkK1N|c4KM7:TR?= NGLTSFNUSU6JRWK=
IST-SL1 M4C1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1KxVWlEPTB;Mz6yPVQ3PSEQvF2= M3TSdHNCVkeHUh?=
G-401 NVzJNFh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\6fmlEPTB;Mz6yPVgxQCEQvF2= NIrxUphUSU6JRWK=
OVCAR-5 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNwM{[zOVIh|ryP NWPBdHhsW0GQR1XS
EW-1 M37Femdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTNwNEC1OFQh|ryP NXiydHVjW0GQR1XS
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CESS MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SyOGlEPTB;MUeuPVMzPiEQvF2= MYrTRW5ITVJ?
EW-11 NHPNUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DLOmlEPTB;MUeuPVk2QCEQvF2= M3HXWHNCVkeHUh?=
TE-8 M3vTUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfnTWM2OD1zOD6wOlY6KM7:TR?= MX7TRW5ITVJ?
UACC-257 NEP6bYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTF6LkKwOlIh|ryP MY\TRW5ITVJ?
NCI-H226 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHqTWM2OD1zOD64Nlk6KM7:TR?= NWjBe2pDW0GQR1XS
NCI-H748 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDyTWM2OD1zOD64OVg2KM7:TR?= MXPTRW5ITVJ?
NCI-H1299 M2HVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;aTWM2OD1zOD64PVE5KM7:TR?= MnrYV2FPT0WU
IST-MEL1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LJWWlEPTB;MUmuNVc2PCEQvF2= Ml24V2FPT0WU
HCC1187 NH7nTYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF7LkG3PVYh|ryP MXfTRW5ITVJ?
HT-1376 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3rbolwUUN3ME2xPU4zODJ7IN88US=> M2PZVXNCVkeHUh?=
SK-MEL-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF7LkKxOVUh|ryP M3Ox[HNCVkeHUh?=
U031 MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[3foJKSzVyPUG5MlIzOTlizszN MlniV2FPT0WU
NCI-H524 Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf2e5lbUUN3ME2xPU42PzJ3IN88US=> M1f4W3NCVkeHUh?=
KU812 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX30XVEyUUN3ME2xPU42QTR2IN88US=> MXfTRW5ITVJ?
NB10 NVv6emhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF7Lk[yOlgh|ryP MlqzV2FPT0WU
NOS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\Ob2lEPTB;MkCuNVU4PyEQvF2= M3:2cHNCVkeHUh?=
EW-7 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETvd4VKSzVyPUKwMlE3OjhizszN MojvV2FPT0WU
Raji MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P0cWlEPTB;MkCuNlU3QCEQvF2= MlHHV2FPT0WU
LB2518-MEL M3HzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzMNY03UUN3ME2yNE4{QTV|IN88US=> NH[zV4RUSU6JRWK=
PANC-10-05 NVW3Zm9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJyLkS2NVMh|ryP MkfmV2FPT0WU
MZ2-MEL MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED5dppKSzVyPUKwMlU5OTRizszN M1zTXHNCVkeHUh?=
MFE-280 NIf6VZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPoe49KSzVyPUKxMlMyQDhizszN MnS1V2FPT0WU
RKO NEDJUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJzLkOyNFIh|ryP NInWbZJUSU6JRWK=
KMOE-2 M123W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDOV4RKSzVyPUKxMlMzQDhizszN M3XUO3NCVkeHUh?=
K5 MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjDdnRMUUN3ME2yNU4{QDl|IN88US=> MkT3V2FPT0WU
NCI-H64 Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[4TWM2OD1{MT60O|U3KM7:TR?= MVXTRW5ITVJ?
K-562 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnSVnRKSzVyPUKxMlQ6PzFizszN M4jafnNCVkeHUh?=
HCE-T MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJzLkWwPVQh|ryP MmrPV2FPT0WU
COLO-792 NEfkfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[1TGlEPTB;MkGuOVgzPyEQvF2= Ml7NV2FPT0WU
PFSK-1 NXHENmNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJzLk[4N|ch|ryP NELjTGRUSU6JRWK=
DOK NGfvelZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LW[GlEPTB;MkGuO|Y5PyEQvF2= NXi2RZNrW0GQR1XS
NCI-H1882 NILocmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HheGlEPTB;MkGuPFU6PiEQvF2= NYn5WoFiW0GQR1XS
KNS-81-FD M3X5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fYS2lEPTB;MkGuPFY{OSEQvF2= NFXqNWNUSU6JRWK=
OCUB-M Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HQZ2lEPTB;MkGuPVY5QCEQvF2= M2HvNHNCVkeHUh?=
NCI-H1694 MnK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJzLkm4OlMh|ryP MULTRW5ITVJ?
LS-513 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\sPWlEPTB;MkKuNFM3PyEQvF2= MoPNV2FPT0WU
NCI-H2122 M2qyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzQS|dKSzVyPUKyMlE3PzdizszN MYrTRW5ITVJ?
IMR-5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJ{LkK4O{DPxE1? M3u4O3NCVkeHUh?=
SNU-C2B MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDBUYxKSzVyPUKyMlY4PDZizszN NEH1bZRUSU6JRWK=
A498 NFfqT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\X[I9KSzVyPUKyMlgyPzdizszN MkDNV2FPT0WU
NCI-H727 M{fudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ{Lki4N|Yh|ryP NHHrRnRUSU6JRWK=
SW1573 M2joWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJ|LkC2OFYh|ryP MWHTRW5ITVJ?
RO82-W-1 NXLRN2loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3yTWM2OD1{Mz6yOVEyKM7:TR?= NFXIS3BUSU6JRWK=
SKG-IIIa Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XJdGlEPTB;MkOuN|U1PiEQvF2= MnrzV2FPT0WU
MC-CAR NXeyVWF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrxUG5zUUN3ME2yN{42OTh|IN88US=> MYPTRW5ITVJ?
NCI-H446 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV6wRoROUUN3ME2yN{43ODl|IN88US=> MXXTRW5ITVJ?
PC-14 NH3UNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ|Lk[2NlMh|ryP NULm[41EW0GQR1XS
TGBC1TKB MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj3TWM2OD1{Mz63OFYyKM7:TR?= MljxV2FPT0WU
EFM-19 Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL1WJBDUUN3ME2yOE4yQDR2IN88US=> MmC2V2FPT0WU
SK-N-DZ MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HKU2lEPTB;MkSuOFk4PyEQvF2= M2TqVXNCVkeHUh?=
NCI-H661 NGrXb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M362WGlEPTB;MkSuOVIyPyEQvF2= NHfuOIhUSU6JRWK=
SW1990 NXvFfJBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJ2LkW4PFMh|ryP Mnf5V2FPT0WU
SW684 NETiTYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT2enNKSzVyPUK0Mlc3OjRizszN NVvObVhEW0GQR1XS
Ca-Ski NFnW[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCyTWM2OD1{ND65NlM4KM7:TR?= MUXTRW5ITVJ?
TGW NF\uVIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\GZldqUUN3ME2yOU4zOzN5IN88US=> NU\Ue|g{W0GQR1XS
CaR-1 NVHTenhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TWZ2lEPTB;MkWuN|U4KM7:TR?= NHnNXllUSU6JRWK=
D-247MG NXPzPW4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXOXJF1UUN3ME2yOU41PzR|IN88US=> M2L2N3NCVkeHUh?=
CCRF-CEM Mlu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XVRmlEPTB;MkWuO|Q2QSEQvF2= M3m1eHNCVkeHUh?=
CAPAN-1 NH\UbJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq3R5J4UUN3ME2yOU44PTBzIN88US=> NF2ybFVUSU6JRWK=
CP50-MEL-B MlLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPRTWM2OD1{NT65PVAyKM7:TR?= NV3pfXJWW0GQR1XS
FADU Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\QVGdKSzVyPUK2MlUyPTJizszN M2fqeHNCVkeHUh?=
Daudi NV\JO4lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLYfJZ[UUN3ME2yOk42OTV6IN88US=> M2ezd3NCVkeHUh?=
U-87-MG Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnu[mVKSzVyPUK2MlU{ODVizszN NWLRW20yW0GQR1XS
DSH1 M1z2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjXVHlKSzVyPUK2MlU1ODZizszN MoXDV2FPT0WU
KYSE-520 NWX2dlFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfKTZFJUUN3ME2yOk42PTV|IN88US=> M1jXSnNCVkeHUh?=
HuH-7 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJ4LkmwPFYh|ryP MkPZV2FPT0WU
U-2-OS NGXOZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJ5LkCyO|Eh|ryP MmP5V2FPT0WU
LU-99A M4HXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvKTWM2OD1{Nz6xO|U1KM7:TR?= MojPV2FPT0WU
T98G MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJ5LkG5O|Mh|ryP NYTl[YNrW0GQR1XS
MZ7-mel NH3X[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDsTWM2OD1{Nz61OVQ5KM7:TR?= MlrMV2FPT0WU
SNU-C1 M13S[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnqXZNKSzVyPUK3MlY1QTFizszN NX;sS|hVW0GQR1XS
MDA-MB-175-VII MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXyTWM2OD1{Nz62PVc2KM7:TR?= MYXTRW5ITVJ?
HuP-T3 M1zMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPITWM2OD1{OD6wOFk2KM7:TR?= MlfXV2FPT0WU
T-24 M{H6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjpTWM2OD1{OD6xPVI2KM7:TR?= MVfTRW5ITVJ?
HDLM-2 NGTOdoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfOSFdyUUN3ME2yPE4zPDV7IN88US=> M2XPNXNCVkeHUh?=
NCI-H1651 NF:5cGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJ6LkK1PVIh|ryP NF\3SIhUSU6JRWK=
SK-N-AS NFzPRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nCXmlEPTB;MkiuN|E4OSEQvF2= NYjj[XdqW0GQR1XS
NY MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDCO5VKSzVyPUK4MlY2PzlizszN MnvaV2FPT0WU
D-283MED NVfo[2d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrFd5pTUUN3ME2yPE45PzB6IN88US=> MULTRW5ITVJ?
KLE Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PMfmlEPTB;MkiuPVkxPiEQvF2= NVzQVodbW0GQR1XS
NCI-H28 NUnKNoY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP4TWM2OD1{OT6wNVIh|ryP NWi1U2M{W0GQR1XS
TE-1 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJ7LkKxOlch|ryP MWrTRW5ITVJ?
SK-MEL-24 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTnTWM2OD1{OT61OFY3KM7:TR?= M2rpcXNCVkeHUh?=
CAL-54 M33obGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrH[nhKSzVyPUK5MlYxPDZizszN NWfFPIJmW0GQR1XS
A673 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTnTWM2OD1{OT63N|Ih|ryP NIPwb5pUSU6JRWK=
HEC-1 NGSyVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDuTWM2OD1|MD6wNFU{KM7:TR?= NFHxb3JUSU6JRWK=
LS-411N MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUGyXXNIUUN3ME2zNE4yPDd3IN88US=> NVrufFBiW0GQR1XS
SW962 NYDST5VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPwNZVCUUN3ME2zNE4zPDd5IN88US=> MnnsV2FPT0WU
OVCAR-8 NVi3O4U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHETWM2OD1|MD62O|k1KM7:TR?= MXjTRW5ITVJ?
NCI-H630 NYXNN4VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO1em84UUN3ME2zNE45QTV|IN88US=> NYfYRnFiW0GQR1XS
D-263MG NVnvOJdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTNzLkC0NlQh|ryP MWDTRW5ITVJ?
NCI-H596 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X3emlEPTB;M{GuNFYzOSEQvF2= M2rKVnNCVkeHUh?=
BB49-HNC NIjMXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3XdWlKSzVyPUOxMlEyOiEQvF2= NUe2UnpMW0GQR1XS
KYSE-70 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrNTWM2OD1|MT6zNFA5KM7:TR?= MULTRW5ITVJ?
LAN-6 NVzpZ|dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zXXGlEPTB;M{GuOFk6OiEQvF2= NIXoUmNUSU6JRWK=
NCI-H2228 NUjkU21oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C4PGlEPTB;M{GuOVYzPSEQvF2= NGXJZ3VUSU6JRWK=
SW620 NF;VSJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTNzLk[yPFMh|ryP MYLTRW5ITVJ?
KM-H2 NYHPVmF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTNzLkezNFYh|ryP MWTTRW5ITVJ?
DJM-1 M{jk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moq3TWM2OD1|Mj6xN|g3KM7:TR?= MoLLV2FPT0WU
SW48 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\xTWM2OD1|Mj6zPFI2KM7:TR?= Mn\2V2FPT0WU
NCI-H1793 NFHwfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTN{Lk[xOlMh|ryP MoLNV2FPT0WU
LU-165 MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH2TWM2OD1|Mz6wNFgh|ryP MU\TRW5ITVJ?
EHEB M2Wxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTN|LkC0PVQh|ryP MYrTRW5ITVJ?
NCI-H441 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLRcGFKSzVyPUOzMlIzOzVizszN Ml;xV2FPT0WU
LOXIMVI NUXUcI5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLRNVdzUUN3ME2zN{4{Pjd7IN88US=> MmPqV2FPT0WU
MC-IXC M3Sy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTRTWM2OD1|Mz61OlU2KM7:TR?= NV7afWpEW0GQR1XS
NCI-H522 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPLOWFMUUN3ME2zN{43PTRizszN Mnv6V2FPT0WU
IA-LM MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTN|Lk[3OFYh|ryP MYLTRW5ITVJ?
NCI-H1417 MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\sO2dKSzVyPUOzMlk2QDVizszN M2f3fnNCVkeHUh?=
HCC2218 M4LERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfuZ5NKSzVyPUO1MlIyQDVizszN M{PGdnNCVkeHUh?=
HC-1 M1ruNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DlcWlEPTB;M{WuOFAzPCEQvF2= M4DXb3NCVkeHUh?=
HH MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvnTWM2OD1|NT60NVQyKM7:TR?= NWrPemdXW0GQR1XS
EFE-184 M17uSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO2TWM2OD1|NT62PFI6KM7:TR?= NFTOPWZUSU6JRWK=
NCI-H1355 NH;nZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLWTWM2OD1|NT63O|E5KM7:TR?= NWnNVlFRW0GQR1XS
BV-173 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPETWM2OD1|NT64NlY1KM7:TR?= NFvWeoFUSU6JRWK=
NEC8 M1PLeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\zXpBxUUN3ME2zOk41QTJ2IN88US=> NWfjbXFKW0GQR1XS
SW1463 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLwTWM2OD1|Nj62OVY3KM7:TR?= M4\hNnNCVkeHUh?=
KYSE-140 NF3ZPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDjVm9KSzVyPUO2MlczQThizszN MWfTRW5ITVJ?
no-11 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTRZ4xuUUN3ME2zOk45PTN4IN88US=> MV7TRW5ITVJ?
HCC1937 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LrbGlEPTB;M{euNFE2PCEQvF2= NHzMPXlUSU6JRWK=
LNCaP-Clone-FGC MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDyTWM2OD1|Nz6xPVA{KM7:TR?= NWf2XI5NW0GQR1XS
KARPAS-422 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN5LkS0N|Eh|ryP MkXCV2FPT0WU
RCM-1 MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG0TWM2OD1|Nz61N|U5KM7:TR?= M{TPVnNCVkeHUh?=
A375 NIDKPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTETWM2OD1|Nz63OlQ4KM7:TR?= M2TKUHNCVkeHUh?=
TGBC24TKB NWTQb|lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrnbIxiUUN3ME2zPE4xOjN7IN88US=> NUiwbHJTW0GQR1XS
MDA-MB-453 NHTvfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojOTWM2OD1|OT6wNlE5KM7:TR?= NH61T|JUSU6JRWK=
Capan-2 NF\ONG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HsN2lEPTB;M{muNFUxQSEQvF2= MXnTRW5ITVJ?
SW756 NHzVd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[3N|hKSzVyPUO5MlUxQTFizszN Mo\oV2FPT0WU
KU-19-19 NWHUT4tpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN7Lk[yPFIh|ryP M3jrc3NCVkeHUh?=
NCI-H2170 MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3exbmlEPTB;M{muPVk4PyEQvF2= M1PMNHNCVkeHUh?=
COLO-678 M4HITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTRyLkW5OUDPxE1? NV3yOXduW0GQR1XS
PF-382 M1zlOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTRyLke0PFch|ryP M1K1THNCVkeHUh?=
OAW-42 NHrz[G1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK4Om1KSzVyPUSyMlI6PDJizszN NFXuZlhUSU6JRWK=
LB996-RCC NHfF[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHWVmVrUUN3ME20Nk45ODB6IN88US=> NFvLSINUSU6JRWK=
SAS NGXuSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTR|LkSyPFgh|ryP NI\wSGtUSU6JRWK=
MRK-nu-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH1VIxKSzVyPUS0Mlc1OTRizszN M3njTnNCVkeHUh?=
EoL-1-cell NXvVRphTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIewUXBKSzVyPUS0MlkyOzZizszN M2S0bHNCVkeHUh?=
NCI-H2342 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXYR5dQUUN3ME20OU4yOTF5IN88US=> MlTrV2FPT0WU
NCI-H1703 M3PGSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTR4LkC1PVIh|ryP NHvFNHJUSU6JRWK=
NCI-H187 NFL4NFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTR4LkG4Olkh|ryP M3f6NnNCVkeHUh?=
CP66-MEL NGW1c5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPUTWM2OD12Nj6yO|g6KM7:TR?= MUXTRW5ITVJ?
HCC1569 M2\1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTR4LkW5NVch|ryP MW\TRW5ITVJ?
BL-70 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEmwZZBKSzVyPUS2Mlc4OzdizszN MkKzV2FPT0WU
Saos-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HCNWlEPTB;NEeuN|EzOyEQvF2= MmLpV2FPT0WU
LC-1F M4\BTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR5Lk[xNFUh|ryP MXHTRW5ITVJ?
KY821 NYDUXJhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHOc256UUN3ME20O{43PDN2IN88US=> M4jrfHNCVkeHUh?=
PSN1 MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[2OnA6UUN3ME20PE4yPDBzIN88US=> M1fHbnNCVkeHUh?=
RT4 NWTMNJBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LCcmlEPTB;NEiuPFM4PyEQvF2= NX7n[XB[W0GQR1XS
LS-1034 NWTCNHVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULGRolLUUN3ME20PE45QTV2IN88US=> NWjDUY5TW0GQR1XS
NCI-H1395 NHi0[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR7LkC0PVIh|ryP M2LlXHNCVkeHUh?=
EKVX NFvJZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXjZYt7UUN3ME20PU43PzNzIN88US=> M1fD[HNCVkeHUh?=
IST-MES1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HSdmlEPTB;NEmuPFk1PCEQvF2= NXPSSnpCW0GQR1XS

... Click to View More Cell Line Experimental Data
体内研究 在携带U87MG的小鼠中PF-562271 (< 33 mg/kg 口服)抑制肿瘤中FAK磷酸化并具有时间和剂量依赖特性。PF-562271 (50 mg/kg, 口服，一天两次)对BxPc3异种移植小鼠中肿瘤生长抑制率为86% ，对PC3-M异种移植小鼠中肿瘤生长抑制率为45%。PF-562271 (25mg/kg, 一天两次)处理的携带H125肺部异种移植肿瘤凋亡率提高2倍[1]。 PF-562271 (33 mg/kg,口服)24小时后抑制小鼠中肿瘤细胞的广泛运动。PF-562271 (33 mg/kg, 口服)导致小鼠中E-cadherin动力学的改变，这与减弱的E-cadherin依赖的整体细胞运动有关 [3]。在皮下局部异种移植PC3M-luc-C6的小鼠模型中 PF-562271 (25 mg/kg, 口服，一天两次)导致肿瘤生长率62%的抑制[4]。在胫骨植入MDA-MB-231细胞的大鼠中PF-562271 (5mg/kg, 口服)导致骨钙素和松质骨参数显著而相似的增加同时导致肿瘤生长速度和骨愈合信号的下降[5]。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验：[1]
+ 展开
  • Animal Models: 携带BxPc3或 PC3-M异种移植的无胸腺雌性小鼠
  • Formulation: 5% Gelucire
  • Dosages: 50 mg/kg
  • Administration: 填喂给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
30% PEG400+0.5% Tween80+5% propylene glycol 		30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 507.49
化学式

C21H20F3N7O3S
CAS号 717907-75-0
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项
Selleck产品目录册

FAK Signaling Pathway Map

相关FAK产品

  • PND-1186 (VS-4718) New

    PND-1186 (VS-4718)是一种可逆的选择性FAK抑制剂，IC50为1.5 nM。Phase 1。

  • PF-431396 New

    PF-431396是双PYK2/FAK抑制剂，IC50分别为11nM和2 nM。

  • Defactinib (VS-6063, PF-04554878) New

    Defactinib (VS-6063, PF-04554878)是一种选择性，且口服有效的FAK抑制剂。Phase 2。

  • PF-00562271 Besylate

    PF-00562271 Besylate是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK效果低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。Phase 1。

  • TAE226 (NVP-TAE226)

    TAE226 (NVP-TAE226)是一种有效的FAK抑制剂，IC50为5.5 nM，最有效作用于Pyk2，对InsR， IGF-1R， ALK和c-Met作用效果比其弱10到100倍左右。

  • PF-573228

    PF-573228是一种ATP竞争性的FAK抑制剂，无细胞试验中IC50为4 nM，作用于FAK比作用于Pyk2，CDK1/7 和 GSK-3β选择性高~50到250倍。

  • PF-562271 HCl

    PF-562271 HCl是PF-562271的盐酸盐形式，是一种强效的ATP竞争性的可逆的抑制剂，作用于FAK其IC50为1.5 nM。相比较FAK，对Pyk2的效果少了大约十倍，除了CDKs类的蛋白酶，PF-562271 HCl的选择性相比其他蛋白酶大大约100倍。

  • Ibrutinib (PCI-32765)

    Ibrutinib (PCI-32765)是一种有效的，高选择性的Brutons tyrosine kinase (Btk)抑制剂，无细胞试验中IC50为0.5 nM，对Bmx， CSK， FGR， BRK及HCK适度有效，对EGFR， Yes， ErbB2， JAK3等作用效果较弱。

  • Dasatinib

    Dasatinib是一种新型有效的多靶点抑制剂，作用于Abl，Src和 c-Kit，在无细胞试验中IC50分别为 <1 nM，0.8 nM 和 79 nM。

  • Saracatinib (AZD0530)

    Saracatinib (AZD0530)是一种有效的Src抑制剂，无细胞试验中IC50为2.7 nM，对c-Yes， Fyn， Lyn， Blk， Fgr和Lck也具有活性；但对Abl和EGFR (L858R和L861Q)活性较低。Phase 2/3。

    Features:Saracatinib是第一个作用于人类肿瘤组织Src通路的抑制剂。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID