Sarilumab (anti-IL-6Rα)

目录号:A2011 别名: SAR153191, REGN88 中文名称:西鲁库单抗

For research use only.
Not for use in humans.

Sarilumab (anti-IL-6Rα)是人源anti-IL-6Rα单克隆抗体,与膜结合的和可溶性的IL-6Rα以高亲和力结合。MW: 144.13 KD。

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客户使用Selleck该产品发表文献1篇:

质量管理及产品安全说明书

IL Receptor抑制剂选择性比较

生物活性

产品描述 Sarilumab (anti-IL-6Rα)是人源anti-IL-6Rα单克隆抗体,与膜结合的和可溶性的IL-6Rα以高亲和力结合。MW: 144.13 KD。
靶点
IL-6R (human) [1]
()
IL-6R (monkey) [1]
()
61.9 pM(Kd) 71.9 pM(Kd)
体外研究

Sarilumab (SAR153191/REGN88)是人源anti-IL-6Rα单克隆抗体,与膜结合-和可溶性-人源IL-6Rα以高亲和力结合,阻止顺式和反式IL-6介导的炎症信号通路,没有显著的补体依赖性或抗体依赖性的细胞毒性[1]。Sarilumab对所检测的肿瘤细胞系如DU145、Calu3和A549细胞具有部分生长抑制作用[2]。Sarilumab与重组单体人源和猴源IL-6受体以高亲和力结合,Kd值分别为61.9 pM和71.9 pM。sarilumab与而二聚人源IL-6受体Fc融合蛋白的结合亲和力为12.8 pM。Sarilumab对人源和猴源IL-6受体具有特异性,不与鼠源IL-6R交叉反应[3]

体内研究 在临床前研究中,Sarilumab以剂量依赖性方式抑制IL-6信号[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

抗体信息

CAS No. 1189541-98-7
配制 PBS buffer, pH 7.2
同型 Human IgG1
来源 CHO cells
储存条件 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

技术支持

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常见问题及建议解决方法

  • 问题1:

    How to store the antibody?

  • 回答:

    Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID