Dexamethasone Sodium Phosphate

For research use only. Not for use in humans.

目录号:S4028 别名: Dexamethasone 21-phosphate disodium salt 中文名称:地塞米松磷酸钠

Dexamethasone Sodium Phosphate Chemical Structure

CAS No. 55203-24-2

Dexamethasone (Dexamethasone 21-phosphate disodium salt)是一种白介素受体抑制剂,抑制COX-2

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客户使用Selleck生产的Dexamethasone Sodium Phosphate发表文献22篇:

产品安全说明书

IL Receptor抑制剂选择性比较

生物活性

产品描述 Dexamethasone (Dexamethasone 21-phosphate disodium salt)是一种白介素受体抑制剂,抑制COX-2
特性 对COX-2良好的选择性。
靶点
IL receptor [6] COX-2 [1]
体外研究

Dexamethasone抑制人关节软骨细胞中IL-1诱导的COX-2 mRNA表达。[1]在MC3T3-E1细胞中,Dexamethasone抑制肿瘤坏死因子α (TNFα) 诱导的环氧合酶-2,IC50为1 nM。Dexamethasone与糖皮质激素受体结合,随后与糖皮质激素应答元件结合。[2] Dexamethasone (10 μM)诱导大鼠骨髓基质细胞培养物中成骨细胞的分化,并提高碱性磷酸酶骨钙素,骨涎蛋白,以及骨钙素的mRNA表达。[3] Dexamethasone (5 μM)治疗降低人海马神经前体细胞的分化和SRE驱使的基因表达。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT ; 

PubMed: 29436611     


Dexamethasone (C) promoted Akt phosphorylation in PC3 cells and inhibited Akt phosphorylation in PC3-AR9.

GRP78 / GRP94 / pIREα / IREα / peIF2α / eIF2α CHOP ; 

PubMed: 24691439     


Dexamethasone induced ER stress and activated the UPR in human TM cells. Primary human TM cells obtained from normal human donors were treated with dexamethasone for 48 hours. GRP78, GRP94, CHOP, and phosphorylation of IRE1 and eIF2α were examined by Western blot analysis (n = 3).

BCRP / P-gp / Mrp2 ; 

PubMed: 18524938     


Dexamethasone induced bcrp, p-glycoprotein (p-gp), and mrp2 protein expression in brain endothelial cells. A: representative Western blots demonstrating the concentration-dependent increase in protein expression of bcrp, p-gp, and mrp2 in primary endothelial cells when cultured with dexamethasone for 24 h. Quantitative analysis by densitometry of three different experiments is also shown. B: dexamethasone-induced increase in bcrp, p-gp, and mrp2 expression after incubation of endothelial cells with 250 nM dexamethasone was dependent on the time of exposure. Quantitative analysis by densitometry of three different experiments is also shown. *P < 0.05 vs. untreated cells, **P < 0.01 vs. untreated cells.

29436611 24691439 18524938
Immunofluorescence
GRP78; 

PubMed: 24691439     


Human TM cells were treated with vehicle or dexamethasone for 48 hours and stained with GRP78 and phalloidin (which stains F-actin) (n = 3). Dexamethasone treatment increased actin and GRP78 levels. Scale bars: 50 μm.

24691439
Growth inhibition assay
Cell viability; 

PubMed: 22719835     


(A) Proliferation of MC3T3-E1 cells was measured by CCK8 (colorimetric cell counting kit-8) after cells were treated with 0, 0.001,0.01,0.1, 1.0 and 10.0 µmol/L dexamethasone for 24 hours. treatment with 1 and 10 µmol/L DEX remarkably reduced cell proliferation. B) Cell death was measured by typan blue incorporation after cells were treated with 0, 0.001,0.01,0.1, 1.0 and 10.0 µmol/L dexamethasone for 24 hours. treatment with 1 and 10 µmol/L dexamethasone remarkably increased dead cell population Values are means+SEM (n = 3). *P< 0.05 vs corresponding untreated controls.

22719835
体内研究 在雄性Fischer F344 大鼠体内,Dexamethasone (2毫克/千克)降低80% BrdU标记的肝细胞数量。在雄性Fischer F344 大鼠体内,Dexamethasone (2 毫克/千克)预处理同时抑制部分肝切除术后TNF和IL-6的表达,并显著降低肝细胞的增殖反应。Dexamethasone也会严重减少2-乙酰氨基芴/部分肝切除术(AAF/PH)方案诱导的卵圆细胞的感应和扩张,但是对胆道结扎刺激的胆道细胞增殖没有任何影响。 [4] 在Sprague-Dawley大鼠体内,Dexamethasone (100微克/千克)使BrdU(+)海马祖细胞显著减少59.2%。在Sprague-Dawley大鼠体内,Dexamethasone (100微克/千克)减少颗粒细胞层中ERK的活化。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[5]
- 合并
  • Animal Models: Sprague-Dawley大鼠
  • Dosages: 100微克/千克
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 Water 103 mg/mL (199.45 mM)
DMSO Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 516.4
化学式

C22H30FO8P.2Na

CAS号 55203-24-2
储存条件 粉状
溶于溶剂
别名 Dexamethasone 21-phosphate disodium salt

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04911361 Not yet recruiting Drug: Dexamethasone Dry Eye Research Insight LLC July 26 2021 Phase 4

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