Glucocorticoid Receptor

抑制剂选择性比较

Glucocorticoid Receptor产品

所有产品 Glucocorticoid Receptor抑制剂(1) Glucocorticoid Receptor拮抗剂(1) Glucocorticoid Receptor激动剂(30)

目录号	产品描述	文献引用	实验数据
S1322	Dexamethasone Dexamethasone 是一种有效的半合成的糖皮质激素类甾体药物，也是一种interleukin receptor调节剂，具有抗炎和免疫抑制作用。Dexamethasone 可诱导自噬和线粒体自噬。Dexamethasone 被用于COVID-19临床病人测试中，并发现对危重症患者有一定效果。	Int J Biol Sci, 2020, 16(4):543-552 BMC Cancer, 2020, 20(1):269 Cancer Discov, 2019, 9(5):628-645	Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.
S6608^New	AL082D06 AL082D06是非类固醇的糖皮质激素受体拮抗剂，而对与其高度相关受体如盐皮质激素、雄激素、雌激素和孕酮等无显著结合亲和力。
S1696	Hydrocortisone (cortisol) Hydrocortisone (Cortisol)是一种由肾上腺产生的类固醇激素或糖皮质激素。	Biochem Pharmacol, 2020, 175:113865 Biochem Biophys Res Commun, 2020, 21;526(1):267-272 Cell Oncol (Dordr), 2019, 42(4):459-475
S1737	Prednisolone Prednisolone 是一种人工合成的糖皮质激素，具有抗炎和免疫调节特性。	Ther Adv Hematol, 2020, 11:2040620719898373 Elife, 2019, 8 Int J Mol Sci, 2019, 20(23)	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1622	Prednisone Prednisone 是一种人工合成的皮质类固醇剂，是特别有效的免疫抑制剂的化合物。	PLoS One, 2018, 13(8):e0200725
S1669	Loteprednol etabonate Loteprednol etabonate是一种用于眼科的抗炎皮质类固醇。
S1987	Mometasone furoate Mometasone furoate 是一种糖皮质激素，外用，用于降低皮肤炎症。
S1992	Fluticasone propionate Fluticasone propionate 是一种合成的皮质类固醇，是Fluticasone的衍生物，用于治疗哮喘和过敏性鼻炎（花粉症）。	Nat Med, 2017, 23(4):424-428
S1733	Methylprednisolone Methylprednisolone 是一种人工合成的皮质类固醇，具有抗炎和免疫调节特性。	Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S1286	Budesonide Budesonide 是糖皮质激素类固醇，用于治疗哮喘，非传染性鼻炎。	Sci Rep, 2020, 24;10(1):5363
S1628	Triamcinolone Acetonide Triamcinolone Acetonide是一种更有效的Triamcinolone，比Prednisone效果强8倍。	Theranostics, 2020, 10(1):247-264
S1689	Meprednisone Meprednisone是一种糖皮质激素，也是Prednisone的甲基化衍生物。
S1888	Deflazacort Deflazacort 是一种糖皮质激素，是一种抗炎剂和免疫抑制剂。
S2470	Fluocinolone Acetonide Fluocinolone Acetonide是一种皮质类固醇，与胞浆中糖皮质激素受体结合。
S1688	Betamethasone Dipropionate Betamethasone Dipropionate 是糖皮质激素类固醇，具有抗炎和免疫抑制特性。
S1690	Betamethasone Valerate Betamethasone Valerate 是一种中等强效的糖皮质激素类固醇，具有抗炎和免疫抑制特性。
S2570	Prednisolone Acetate Prednisolone Acetate 是一种合成的皮质类固醇药，是一种特别有效的免疫抑制剂。	J Int Med Res, 2019, 47(6):2655-2665
S1500	Betamethasone Betamethasone是一种糖皮质激素类固醇，具有抗炎和免疫抑制特性。
S4088	Flumethasone Flumethasone是一种糖皮质激素受体激动剂，该复合物结合到核中，造成各种基因激活和抑制。
S1701	Desonide Desonide是一种低效的外用皮质类固醇激素。
S2608	Fluocinonide Fluocinonide 是有效的糖皮质激素类固醇，是外用抗炎药，用于治疗皮肤病如湿疹。
S2584	Clobetasol propionate Clobetasol propionate是一种抗炎的皮质类固醇，用于治疗各种皮肤疾病。	Exp Ther Med, 2019, 18(2):1258-1266
S1933	Triamcinolone Triamcinolone是一种糖皮质激素，有游离醇或酯化形式，可以口服，肌肉注射，局部注射，吸入，或外用，用于治疗以皮质类激素表示的各种疾病。
S3078	Beclomethasone dipropionate Beclomethasone dipropionate是一种强有效的糖皮质激素，用于治疗鼻炎和窦炎。
S2559	Cortisone acetate Cortisone acetate 是Cortisone的乙酸盐形式，是甾体类激素，是一种糖皮质激素。	Cancer Cell Int, 2020, 19;20:58
S5685	Desoximetasone Desoximetasone is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
S3617	(20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT)是人参皂苷中具有神经保护活性的代谢物。它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体，可调节内皮细胞功能。
S4752	Corticosterone Corticosterone是主要的压力激素，一种肾上腺皮质类固醇，具有作为盐皮质激素和糖皮质激素的活性。	Neuroscience, 2019, 411:11-22 Xenobiotica, 2016, 46(10):948-52
S4646	Ciclesonide Ciclesonide是一种糖皮质激素，用于治疗阻塞性气道疾病。
S5486	Fluorometholone Fluorometholone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
S4228	Fluorometholone Acetate Fluorometholone Acetate 是一种合成的皮质类固醇, 用于治疗类固醇反应性眼睛炎症。
S4775	Cortodoxone Cortodoxone, also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

目录号	产品描述	文献引用	实验数据
S1322	Dexamethasone Dexamethasone 是一种有效的半合成的糖皮质激素类甾体药物，也是一种interleukin receptor调节剂，具有抗炎和免疫抑制作用。Dexamethasone 可诱导自噬和线粒体自噬。Dexamethasone 被用于COVID-19临床病人测试中，并发现对危重症患者有一定效果。	Int J Biol Sci,2020, 16(4):543-552 BMC Cancer,2020, 20(1):269 Cancer Discov,2019, 9(5):628-645	Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

目录号

产品描述

文献引用

实验数据

S1322

Dexamethasone

Dexamethasone 是一种有效的半合成的糖皮质激素类甾体药物，也是一种interleukin receptor调节剂，具有抗炎和免疫抑制作用。Dexamethasone 可诱导自噬和线粒体自噬。Dexamethasone 被用于COVID-19临床病人测试中，并发现对危重症患者有一定效果。

Int J Biol Sci,2020, 16(4):543-552

BMC Cancer,2020, 20(1):269

Cancer Discov,2019, 9(5):628-645

目录号	产品描述	文献引用	实验数据
S6608^New	AL082D06 AL082D06是非类固醇的糖皮质激素受体拮抗剂，而对与其高度相关受体如盐皮质激素、雄激素、雌激素和孕酮等无显著结合亲和力。

目录号

产品描述

文献引用

实验数据

S6608^New

AL082D06

AL082D06是非类固醇的糖皮质激素受体拮抗剂，而对与其高度相关受体如盐皮质激素、雄激素、雌激素和孕酮等无显著结合亲和力。

目录号	产品描述	文献引用	实验数据
S1696	Hydrocortisone (cortisol) Hydrocortisone (Cortisol)是一种由肾上腺产生的类固醇激素或糖皮质激素。	Biochem Pharmacol, 2020, 175:113865 Biochem Biophys Res Commun, 2020, 21;526(1):267-272 Cell Oncol (Dordr), 2019, 42(4):459-475
S1737	Prednisolone Prednisolone 是一种人工合成的糖皮质激素，具有抗炎和免疫调节特性。	Ther Adv Hematol, 2020, 11:2040620719898373 Elife, 2019, 8 Int J Mol Sci, 2019, 20(23)	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1622	Prednisone Prednisone 是一种人工合成的皮质类固醇剂，是特别有效的免疫抑制剂的化合物。	PLoS One, 2018, 13(8):e0200725
S1669	Loteprednol etabonate Loteprednol etabonate是一种用于眼科的抗炎皮质类固醇。
S1987	Mometasone furoate Mometasone furoate 是一种糖皮质激素，外用，用于降低皮肤炎症。
S1992	Fluticasone propionate Fluticasone propionate 是一种合成的皮质类固醇，是Fluticasone的衍生物，用于治疗哮喘和过敏性鼻炎（花粉症）。	Nat Med, 2017, 23(4):424-428
S1733	Methylprednisolone Methylprednisolone 是一种人工合成的皮质类固醇，具有抗炎和免疫调节特性。	Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S1286	Budesonide Budesonide 是糖皮质激素类固醇，用于治疗哮喘，非传染性鼻炎。	Sci Rep, 2020, 24;10(1):5363
S1628	Triamcinolone Acetonide Triamcinolone Acetonide是一种更有效的Triamcinolone，比Prednisone效果强8倍。	Theranostics, 2020, 10(1):247-264
S1689	Meprednisone Meprednisone是一种糖皮质激素，也是Prednisone的甲基化衍生物。
S1888	Deflazacort Deflazacort 是一种糖皮质激素，是一种抗炎剂和免疫抑制剂。
S2470	Fluocinolone Acetonide Fluocinolone Acetonide是一种皮质类固醇，与胞浆中糖皮质激素受体结合。
S1688	Betamethasone Dipropionate Betamethasone Dipropionate 是糖皮质激素类固醇，具有抗炎和免疫抑制特性。
S1690	Betamethasone Valerate Betamethasone Valerate 是一种中等强效的糖皮质激素类固醇，具有抗炎和免疫抑制特性。
S2570	Prednisolone Acetate Prednisolone Acetate 是一种合成的皮质类固醇药，是一种特别有效的免疫抑制剂。	J Int Med Res, 2019, 47(6):2655-2665
S1500	Betamethasone Betamethasone是一种糖皮质激素类固醇，具有抗炎和免疫抑制特性。
S4088	Flumethasone Flumethasone是一种糖皮质激素受体激动剂，该复合物结合到核中，造成各种基因激活和抑制。
S1701	Desonide Desonide是一种低效的外用皮质类固醇激素。
S2608	Fluocinonide Fluocinonide 是有效的糖皮质激素类固醇，是外用抗炎药，用于治疗皮肤病如湿疹。
S2584	Clobetasol propionate Clobetasol propionate是一种抗炎的皮质类固醇，用于治疗各种皮肤疾病。	Exp Ther Med, 2019, 18(2):1258-1266
S1933	Triamcinolone Triamcinolone是一种糖皮质激素，有游离醇或酯化形式，可以口服，肌肉注射，局部注射，吸入，或外用，用于治疗以皮质类激素表示的各种疾病。
S3078	Beclomethasone dipropionate Beclomethasone dipropionate是一种强有效的糖皮质激素，用于治疗鼻炎和窦炎。
S2559	Cortisone acetate Cortisone acetate 是Cortisone的乙酸盐形式，是甾体类激素，是一种糖皮质激素。	Cancer Cell Int, 2020, 19;20:58
S5685	Desoximetasone Desoximetasone is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
S3617	(20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT)是人参皂苷中具有神经保护活性的代谢物。它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体，可调节内皮细胞功能。
S4752	Corticosterone Corticosterone是主要的压力激素，一种肾上腺皮质类固醇，具有作为盐皮质激素和糖皮质激素的活性。	Neuroscience, 2019, 411:11-22 Xenobiotica, 2016, 46(10):948-52
S4646	Ciclesonide Ciclesonide是一种糖皮质激素，用于治疗阻塞性气道疾病。
S5486	Fluorometholone Fluorometholone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
S4228	Fluorometholone Acetate Fluorometholone Acetate 是一种合成的皮质类固醇, 用于治疗类固醇反应性眼睛炎症。
S4775	Cortodoxone Cortodoxone, also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

研究领域

产品类型

Glucocorticoid Receptor

抑制剂选择性比较

Glucocorticoid Receptor产品