Glucocorticoid Receptor
抑制剂选择性比较
Glucocorticoid Receptor产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1322 |
DexamethasoneDexamethasone 是一种有效的半合成的糖皮质激素类甾体药物,也是一种interleukin receptor调节剂,具有抗炎和免疫抑制作用。Dexamethasone 可诱导自噬和线粒体自噬。Dexamethasone 被用于COVID-19临床病人测试中,并发现对危重症患者有一定效果。 |
![]() ![]() Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments. |
|
S2606 |
MifepristoneMifepristone (RU486, C-1073) 是一种异常活跃的孕激素受体 progesterone receptor 和糖皮质激素受体 glucocorticoid receptor 拮抗剂,IC50分别为0.2 nM和2.6 nM。Mifepristone 可促进细胞自噬和细胞凋亡,降低 Bcl-2 表达水平而增加Beclin1水平,并伴随Bcl-2和Beclin1之间的相互作用减弱。 |
![]() ![]() Myogenic differentiation assay to determine the GR specificity of DEX by using RU-486 (10 uM). Immunofluorescence detection of MyHC (red) and DAPI counterstaining of nuclei (blue) was used to detect myotubes. The scale bar is 50 um.
|
|
S6608 |
AL082D06AL082D06是非类固醇的糖皮质激素受体拮抗剂,而对与其高度相关受体如盐皮质激素、雄激素、雌激素和孕酮等无显著结合亲和力。 |
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S1696 |
Hydrocortisone (cortisol)Hydrocortisone (Cortisol)是一种由肾上腺产生的类固醇激素或糖皮质激素。 |
||
S1737 |
PrednisolonePrednisolone 是一种人工合成的糖皮质激素,具有抗炎和免疫调节特性。 |
![]() ![]() Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from |
|
S1622 |
PrednisonePrednisone 是一种人工合成的皮质类固醇剂,是特别有效的免疫抑制剂的化合物。 |
||
S1669 |
Loteprednol etabonateLoteprednol etabonate是一种用于眼科的抗炎皮质类固醇。 |
||
S1987 |
Mometasone furoateMometasone Furoate (SCH-32088)是一种糖皮质激素,外用,用于降低皮肤炎症。 |
||
S1992 |
Fluticasone propionateFluticasone Propionate (CCI-187881) 是一种合成的皮质类固醇,是Fluticasone的衍生物,用于治疗哮喘和过敏性鼻炎(花粉症)。 |
||
S1733 |
MethylprednisoloneMethylprednisolone (NSC-19987) 是一种人工合成的皮质类固醇,具有抗炎和免疫调节特性。Methylprednisolone 可激活 ACE2 和降低 IL-6 水平,这样来改善严重或危重的 COVID-19。Methylprednisolone 可显著地减少自噬和凋亡。 |
![]() ![]() Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
|
|
S1286 |
BudesonideBudesonide 是糖皮质激素类固醇,用于治疗哮喘,非传染性鼻炎。 |
||
S1628 |
Triamcinolone AcetonideTriamcinolone Acetonide是一种更有效的Triamcinolone,比Prednisone效果强8倍。 |
||
S1689 |
MeprednisoneMeprednisone (NSC 527579, SCH 4358)是一种糖皮质激素,也是Prednisone的甲基化衍生物。 |
||
S1888 |
DeflazacortDeflazacort (MDL 458) 是一种糖皮质激素,是一种抗炎剂和免疫抑制剂。 |
||
S2470 |
Fluocinolone AcetonideFluocinolone Acetonide (Flucort-N) 是一种皮质类固醇,与胞浆中糖皮质激素受体结合。 |
||
S1688 |
Betamethasone DipropionateBetamethasone Dipropionate (SCH 11460) 是糖皮质激素类固醇,具有抗炎和免疫抑制特性。 |
||
S1690 |
Betamethasone ValerateBetamethasone Valerate 是一种中等强效的糖皮质激素类固醇,具有抗炎和免疫抑制特性。 |
||
S2570 |
Prednisolone AcetatePrednisolone Acetate (Omnipred) 是一种合成的皮质类固醇药,是一种特别有效的免疫抑制剂。 |
||
S1500 |
BetamethasoneBetamethasone (NSC-39470, SCH-4831)是一种糖皮质激素类固醇,具有抗炎和免疫抑制特性。 |
||
S4088 |
FlumethasoneFlumethasone (RS-2177, NSC-54702)是一种糖皮质激素受体激动剂,该复合物结合到核中,造成各种基因激活和抑制。 |
||
S1701 |
DesonideDesonide是一种低效的外用皮质类固醇激素。 |
||
S2608 |
FluocinonideFluocinonide 是有效的糖皮质激素类固醇,是外用抗炎药,用于治疗皮肤病如湿疹。 |
||
S2584 |
Clobetasol propionateClobetasol propionate (CGP9555, CCl 4725)是一种抗炎的皮质类固醇,用于治疗各种皮肤疾病。 |
||
S1933 |
TriamcinoloneTriamcinolone是一种糖皮质激素,有游离醇或酯化形式,可以口服,肌肉注射,局部注射,吸入,或外用,用于治疗以皮质类激素表示的各种疾病。 |
||
S3078 |
Beclomethasone dipropionateBeclomethasone dipropionate是一种强有效的糖皮质激素,用于治疗鼻炎和窦炎。 |
||
S2559 |
Cortisone acetateCortisone acetate (Cortone, NSC 49420)是Cortisone的乙酸盐形式,是甾体类激素,是一种糖皮质激素。 |
||
S5685 |
DesoximetasoneDesoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
||
S3617 |
(20S)-Protopanaxatriol(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT)是人参皂苷中具有神经保护活性的代谢物。它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体,可调节内皮细胞功能。 |
||
S4752 |
CorticosteroneCorticosterone (17-deoxycortisol, 11β,21-dihydroxyprogesterone)是主要的压力激素,一种肾上腺皮质类固醇,具有作为盐皮质激素和糖皮质激素的活性。 |
||
S4646 |
CiclesonideCiclesonide (Alvesco, Omnaris, RPR251526, Zetonna)是一种糖皮质激素,用于治疗阻塞性气道疾病。 |
||
S5486 |
FluorometholoneFluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
||
S4228 |
Fluorometholone AcetateFluorometholone Acetate (NSC 47438) 是一种合成的皮质类固醇, 用于治疗类固醇反应性眼睛炎症。 |
||
S4775 |
CortodoxoneCortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1322 |
DexamethasoneDexamethasone 是一种有效的半合成的糖皮质激素类甾体药物,也是一种interleukin receptor调节剂,具有抗炎和免疫抑制作用。Dexamethasone 可诱导自噬和线粒体自噬。Dexamethasone 被用于COVID-19临床病人测试中,并发现对危重症患者有一定效果。 |
![]() ![]() Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2606 |
MifepristoneMifepristone (RU486, C-1073) 是一种异常活跃的孕激素受体 progesterone receptor 和糖皮质激素受体 glucocorticoid receptor 拮抗剂,IC50分别为0.2 nM和2.6 nM。Mifepristone 可促进细胞自噬和细胞凋亡,降低 Bcl-2 表达水平而增加Beclin1水平,并伴随Bcl-2和Beclin1之间的相互作用减弱。 |
![]() ![]() Myogenic differentiation assay to determine the GR specificity of DEX by using RU-486 (10 uM). Immunofluorescence detection of MyHC (red) and DAPI counterstaining of nuclei (blue) was used to detect myotubes. The scale bar is 50 um.
|
|
S6608 |
AL082D06AL082D06是非类固醇的糖皮质激素受体拮抗剂,而对与其高度相关受体如盐皮质激素、雄激素、雌激素和孕酮等无显著结合亲和力。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1696 |
Hydrocortisone (cortisol)Hydrocortisone (Cortisol)是一种由肾上腺产生的类固醇激素或糖皮质激素。 |
||
S1737 |
PrednisolonePrednisolone 是一种人工合成的糖皮质激素,具有抗炎和免疫调节特性。 |
![]() ![]() Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from |
|
S1622 |
PrednisonePrednisone 是一种人工合成的皮质类固醇剂,是特别有效的免疫抑制剂的化合物。 |
||
S1669 |
Loteprednol etabonateLoteprednol etabonate是一种用于眼科的抗炎皮质类固醇。 |
||
S1987 |
Mometasone furoateMometasone Furoate (SCH-32088)是一种糖皮质激素,外用,用于降低皮肤炎症。 |
||
S1992 |
Fluticasone propionateFluticasone Propionate (CCI-187881) 是一种合成的皮质类固醇,是Fluticasone的衍生物,用于治疗哮喘和过敏性鼻炎(花粉症)。 |
||
S1733 |
MethylprednisoloneMethylprednisolone (NSC-19987) 是一种人工合成的皮质类固醇,具有抗炎和免疫调节特性。Methylprednisolone 可激活 ACE2 和降低 IL-6 水平,这样来改善严重或危重的 COVID-19。Methylprednisolone 可显著地减少自噬和凋亡。 |
![]() ![]() Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
|
|
S1286 |
BudesonideBudesonide 是糖皮质激素类固醇,用于治疗哮喘,非传染性鼻炎。 |
||
S1628 |
Triamcinolone AcetonideTriamcinolone Acetonide是一种更有效的Triamcinolone,比Prednisone效果强8倍。 |
||
S1689 |
MeprednisoneMeprednisone (NSC 527579, SCH 4358)是一种糖皮质激素,也是Prednisone的甲基化衍生物。 |
||
S1888 |
DeflazacortDeflazacort (MDL 458) 是一种糖皮质激素,是一种抗炎剂和免疫抑制剂。 |
||
S2470 |
Fluocinolone AcetonideFluocinolone Acetonide (Flucort-N) 是一种皮质类固醇,与胞浆中糖皮质激素受体结合。 |
||
S1688 |
Betamethasone DipropionateBetamethasone Dipropionate (SCH 11460) 是糖皮质激素类固醇,具有抗炎和免疫抑制特性。 |
||
S1690 |
Betamethasone ValerateBetamethasone Valerate 是一种中等强效的糖皮质激素类固醇,具有抗炎和免疫抑制特性。 |
||
S2570 |
Prednisolone AcetatePrednisolone Acetate (Omnipred) 是一种合成的皮质类固醇药,是一种特别有效的免疫抑制剂。 |
||
S1500 |
BetamethasoneBetamethasone (NSC-39470, SCH-4831)是一种糖皮质激素类固醇,具有抗炎和免疫抑制特性。 |
||
S4088 |
FlumethasoneFlumethasone (RS-2177, NSC-54702)是一种糖皮质激素受体激动剂,该复合物结合到核中,造成各种基因激活和抑制。 |
||
S1701 |
DesonideDesonide是一种低效的外用皮质类固醇激素。 |
||
S2608 |
FluocinonideFluocinonide 是有效的糖皮质激素类固醇,是外用抗炎药,用于治疗皮肤病如湿疹。 |
||
S2584 |
Clobetasol propionateClobetasol propionate (CGP9555, CCl 4725)是一种抗炎的皮质类固醇,用于治疗各种皮肤疾病。 |
||
S1933 |
TriamcinoloneTriamcinolone是一种糖皮质激素,有游离醇或酯化形式,可以口服,肌肉注射,局部注射,吸入,或外用,用于治疗以皮质类激素表示的各种疾病。 |
||
S3078 |
Beclomethasone dipropionateBeclomethasone dipropionate是一种强有效的糖皮质激素,用于治疗鼻炎和窦炎。 |
||
S2559 |
Cortisone acetateCortisone acetate (Cortone, NSC 49420)是Cortisone的乙酸盐形式,是甾体类激素,是一种糖皮质激素。 |
||
S5685 |
DesoximetasoneDesoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
||
S3617 |
(20S)-Protopanaxatriol(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT)是人参皂苷中具有神经保护活性的代谢物。它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体,可调节内皮细胞功能。 |
||
S4752 |
CorticosteroneCorticosterone (17-deoxycortisol, 11β,21-dihydroxyprogesterone)是主要的压力激素,一种肾上腺皮质类固醇,具有作为盐皮质激素和糖皮质激素的活性。 |
||
S4646 |
CiclesonideCiclesonide (Alvesco, Omnaris, RPR251526, Zetonna)是一种糖皮质激素,用于治疗阻塞性气道疾病。 |
||
S5486 |
FluorometholoneFluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
||
S4228 |
Fluorometholone AcetateFluorometholone Acetate (NSC 47438) 是一种合成的皮质类固醇, 用于治疗类固醇反应性眼睛炎症。 |
||
S4775 |
CortodoxoneCortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |