SIK

所有产品 SIK抑制剂(4)

目录号	产品描述	文献引用	实验数据
S7565	WH-4-023 WH-4-023是一种有效的，口服具有活性的Lck/Src抑制剂，无细胞试验中IC50分别为2 nM 和 6 nM。对p38α和KDR的选择性低300倍以上，还能有效抑制SIK（对SIK1、2、3的IC50分别为10、22、60 nM）。	Cell Rep, 2020, 17;30(11):3917-3931 Cancers (Basel), 2020, 27;12(5)pii: E1087 Cell Stem Cell, 2019, 24(5):724-735	(G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.
S0051^New	YKL 06-061 YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.
S8543^New	ARN-3236 ARN-3236 是一种有效的、可口服的、选择性的 salt-inducible kinase 2 (SIK2) 抑制剂，对SIK2、SIK1和SIK3的IC50值分别为 <1 nM、21.63 nM和6.63 nM。ARN-3236 在癌细胞中诱导凋亡。
S8393^New	HG-9-91-01 (SIK inhibitor 1) HG-9-91-01 is a potent and highly selective inhibitor of SIK1, SIK2 and SIK3, with IC50 values of 0.92 nM, 6.6 nM and 9.6 nM, respectively.

目录号	产品描述	文献引用	实验数据
S7565	WH-4-023 WH-4-023是一种有效的，口服具有活性的Lck/Src抑制剂，无细胞试验中IC50分别为2 nM 和 6 nM。对p38α和KDR的选择性低300倍以上，还能有效抑制SIK（对SIK1、2、3的IC50分别为10、22、60 nM）。	Cell Rep,2020, 17;30(11):3917-3931 Cancers (Basel),2020, 27;12(5)pii: E1087 Cell Stem Cell,2019, 24(5):724-735	(G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.
S0051^New	YKL 06-061 YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.
S8543^New	ARN-3236 ARN-3236 是一种有效的、可口服的、选择性的 salt-inducible kinase 2 (SIK2) 抑制剂，对SIK2、SIK1和SIK3的IC50值分别为 <1 nM、21.63 nM和6.63 nM。ARN-3236 在癌细胞中诱导凋亡。
S8393^New	HG-9-91-01 (SIK inhibitor 1) HG-9-91-01 is a potent and highly selective inhibitor of SIK1, SIK2 and SIK3, with IC50 values of 0.92 nM, 6.6 nM and 9.6 nM, respectively.