DBH 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S2695 Nepicastat (SYN-117) HCl

Nepicastat (SYN-117) HCl是一种有效的,选择性的牛和人类dopamine-β-hydroxylase(多巴胺-β-羟氨)抑制剂,IC50分别为8.5 nM和9 nM,对12种其他酶13种神经递质受体几乎没有亲和力。

Selective Human dopamine-beta-hydroxylase, IC50: 9 nM; Bovine dopamine-beta-hydroxylase, IC50: 8.5 nM
S4926 (R)-Nepicastat HCl

(R)-Nepicastat HCl是Nepicastat HCl的R-对映体,是一种有效的,选择性的抑制剂,作用于牛和人类dopamine-β-hydroxylase(多巴胺-β-羟化酶)IC50分别为25.1 nM和18.3 nM,对12种其他酶和13种神经递质受体具有极其微弱的亲和力。

Selective Human dopamine-beta-hydroxylase, IC50: 18.3 nM; Bovine dopamine-beta-hydroxylase, IC50: 25.1 nM
S3273 Hypericin

Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).

Selective