JMJD2 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8601 CP2

CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.

Selective KDM4C, IC50: 29 nM; KDM4A, IC50: 42 nM
S7296 ML324

ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂, 其对JMJD2E的IC50为920 nM。

Selective JMJD2, IC50: 920 nM
S0201 Z-JIB-04 (NSC 693627)

Z-JIB-04 (NSC 693627) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

Pan JMJD2D, IC50: 290 nM; JMJD2C, IC50: 1100 nM; JMJD2B, IC50: 435 nM; JMJD2A, IC50: 445 nM; JMJD2E, IC50: 340 nM
S7281 JIB-04

JIB-04是一种广谱的选择性Jumonji histone demethylase抑制剂,无细胞试验中对JARID1A,JMJD2E,JMJD3,JMJD2A,JMJD2B,JMJD2C和JMJD2D的IC50分别是230 nM,340 nM,855 nM,445 nM,435 nM,1100 nM和290 nM。

Pan JMJD2D, IC50: 290 nM; JMJD2B, IC50: 435 nM; JMJD2A, IC50: 445 nM; JMJD2E, IC50: 340 nM
S7234 IOX1

IOX1 是2OG oxygenases强效的广谱抑制剂, 包括JmjC demethylases

Pan KDM4C, IC50: 0.6 μM