• PTP family
  • DUSP
  • PPP family
  • CaN
  • ALP

PPP-family 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S7573 GSK2830371 GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM. Selective Wip1 phosphatase, IC50: 6 nM
S0744 Raphin1 acetate Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM. Selective R15B-PP1c, Kd: 0.033 μM
S0528 Raphin1 Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM. Selective R15B-PP1c, Kd: 33 nM
S5452 Sanguinarine chloride Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. Selective PP2C, Ki: 0.68 μM
S7485 CCT007093 CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. Selective PPM1D, IC50: 8.4 μM
S7437 Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. Selective
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