STK 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S0431 ML281

ML281 is a potent and selective inhibitor of STK33 with IC50 of 14 nM.

Selective STK33, IC50: 0.014 μM
S7083 Ceritinib (LDK378)

Ceritinib (LDK378)是一种有效的ALK抑制剂,在无细胞试验中IC50为0.2 nM,与作用于IGF-1R和InsR相比,选择性分别高40和35倍。Phase 3。

Selective STK22D, IC50: 23 nM
S4967 Ceritinib dihydrochloride

Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.

Selective STK22D, IC50: 23 nM
S8864 ZT-12-037-01

ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM.

Selective STK19, IC50: 23.96 nM; STK19 (D89N), IC50: 27.94 nM