Ceritinib (LDK378)

目录号:S7083

仅限科研使用

Ceritinib (LDK378)是一种有效的ALK抑制剂,在无细胞试验中IC50为0.2 nM。Ceritinib (LDK378)还可抑制IGF-1RInsRSTK22DFLT3对应的IC50值分别为8 nM、7 nM、23 nM和60 nM。Phase 3。

Ceritinib (LDK378) Chemical Structure

CAS: 1032900-25-6

规格 价格 库存 购买数量
RMB 1182.86 现货
RMB 3868.47 现货
RMB 10720.71 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Ceritinib (LDK378)发表文献88篇:

产品安全说明书

ALK抑制剂选择性比较

相关ALK产品

生物活性

产品描述 Ceritinib (LDK378)是一种有效的ALK抑制剂,在无细胞试验中IC50为0.2 nM。Ceritinib (LDK378)还可抑制IGF-1RInsRSTK22DFLT3对应的IC50值分别为8 nM、7 nM、23 nM和60 nM。Phase 3。
特性 不与c-Met交叉反应,对体内葡萄糖稳态比TAE684效果好,有效作用于 Crizotinib复发的肿瘤。
靶点
ALK [1]
(Cell-free assay)
Insulin Receptor [1]
(Cell-free assay)
IGF-1R [1]
(Cell-free assay)
STK22D [1]
(Cell-free assay)
FLT3 [1]
(Cell-free assay)
0.2 nM 7 nM 8 nM 23 nM 60 nM
体外研究

LDK378作用于Ba/F3-NPM-ALK和Karpas290细胞,具有显著的抗增殖活性,IC50分别为26.0 nM 和 22.8 nM,作用于Ba/F3-Tel-InsR 和Ba/F3-WT细胞,IC50分别为319.5 nM 和 2477 nM。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Parental(+IL3) MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjBT4w4OiCq MoK2SG1UVw>? NEn5V2RKSzVyPUG1PFYhyrFiMUezJI5O NGjqPIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe0PVA{PCd-MkW3OFkxOzR:L3G+
WT 70 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz5XINmPzJiaB?= NH3C[XpFVVOR NVu5UWRKUUN3ME2yNUDDuSB6IH7N M3HCblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{S5NFM1Lz5{NUe0PVA{PDxxYU6=
G1128S 1022 MoDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7rO|IhcA>? M2XNcWROW09? NIGyZnJKSzVyPUGwNkDDuSB|ODDuUS=> NIfjTZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe0PVA{PCd-MkW3OFkxOzR:L3G+
C1156F 1293 Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DzNVczKGh? NE\NZZdFVVOR NVzxSIlJUUN3ME2yNVchyrFiMUG1JI5O NXfQfohoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OFkxOzRpPkK1O|Q6ODN2PD;hQi=>
I1171N 519 M17MS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnMfGw4OiCq MmHoSG1UVw>? NIHNb|dKSzVyPUG4O{DDuSB6NzDuUS=> Mk\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NEmwN|QoRjJ3N{S5NFM1RC:jPh?=
I1171T 445 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVm3NkBp MVHEUXNQ NFK5dmxKSzVyPUiyJOKyKDF{IH7N NYrw[ZdXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OFkxOzRpPkK1O|Q6ODN2PD;hQi=>
F1174I 184 NYDZ[Yt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHqO|IhcA>? NEmxZ|ZFVVOR NI\nTXFKSzVyPUGzJOKyKDBwMTDuUS=> M2LwfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{S5NFM1Lz5{NUe0PVA{PDxxYU6=
N1178H 169 M{DqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlKzO|IhcA>? NVGyRWZXTE2VTx?= MVPJR|UxRTR{INMxJFYhdk1? Mmn2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NEmwN|QoRjJ3N{S5NFM1RC:jPh?=
E1210K 748 NHTCXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUG3NkBp MVnEUXNQ M3Hj[WlEPTB;MUi3JOKyKDh2IH7N MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUCzOEc,OjV5NEmwN|Q9N2F-
C1156F/D1203N 2809 MoTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXq3NkBp NFHPWoZFVVOR MoLxTWM2OD1{NUSgxtEhQTlibl2= NHzudG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe0PVA{PCd-MkW3OFkxOzR:L3G+
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Ba/F3 NA C1156Y NH3OcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T4PVczKGh? NIDjNXNKSzVyPUCuNFcyKM7:TR?= M1rnZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{K3OFAxLz5{NUeyO|QxODxxYU6=
Ba/F3 NA L1196M NYLwWZU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\tdHF3PzJiaB?= Mn;yTWM2OD1yLkC0NkDPxE1? M{n4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{K3OFAxLz5{NUeyO|QxODxxYU6=
Ba/F3 NA L1152R NH76UYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XhOVczKGh? MYrJR|UxRTBwMki4JO69VQ>? M{P5VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{K3OFAxLz5{NUeyO|QxODxxYU6=
Ba/F3 NA G1202R MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHriNIE4OiCq NHHvS2dKSzVyPUCuNlc4KM7:TR?= NFHMclI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyO|QxOCd-MkW3Nlc1ODB:L3G+
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Ba/F3 NA S1206Y MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33RcFczKGh? NXzqWIhvUUN3ME2wMlA{PyEQvF2= Mn3pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5Mke0NFAoRjJ3N{K3OFAxRC:jPh?=
Ba/F3 EA WT MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVe3NkBp NXnXWXFxUUN3ME2wMlAzOSEQvF2= NHrZPYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyO|QxOCd-MkW3Nlc1ODB:L3G+
Ba/F3 EA C1156Y NYnnVFdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkniO|IhcA>? NGHhcYhKSzVyPUCuNFI3KM7:TR?= NW\tcG5RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3Nlc1ODBpPkK1O|I4PDByPD;hQi=>
Ba/F3 EA L1196M NXHlS3pST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDaO|IhcA>? NWnvSoNjUUN3ME2wMlAyQSEQvF2= NVHKSIJuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3Nlc1ODBpPkK1O|I4PDByPD;hQi=>
Ba/F3 EA L1152R M1P3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGflRoQ4OiCq NV3jRXd5UUN3ME2wMlA6QSEQvF2= M2\0WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{K3OFAxLz5{NUeyO|QxODxxYU6=
Ba/F3 EA G1202R MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWi3NkBp MkPETWM2OD1yLkS2O{DPxE1? NGKySJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyO|QxOCd-MkW3Nlc1ODB:L3G+
Ba/F3 EA G1269A NUexe5RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC3NkBp M133dmlEPTB;MD6wN|Mh|ryP Mn;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5Mke0NFAoRjJ3N{K3OFAxRC:jPh?=
Ba/F3 EA S1206Y Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXk[XU4OiCq NVnKO3ZXUUN3ME2wMlA{QCEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{N{SwNEc,OjV5Mke0NFA9N2F-
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NCI-H2228 NWfi[|RXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3j1SVMh\GG7cx?= MVrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ{MkigZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KGy3bXnu[ZNk\W6lZT3iZZNm\CCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR|UxKD1iMD6wNVUh|ryPLh?= NV[3VWI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2Nlc4OjVpPkK5OlI4PzJ3PD;hQi=>
SU-DHL1 M1HQc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\VUlMh\GG7cx?= MYXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTWU1FUExzIHPlcIx{KGGodHXyJFMh\GG7czDifUBtfW2rbnXzZ4Vv[2VvYnHz[YQhS2WubGTpeIVzNUeubzDhd5NigSxiSVO1NEA:KDBwMEG1JO69VS5? NIDaV4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[yO|czPSd-Mkm2Nlc4OjV:L3G+
DFCI114 NFnEOXpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVTrRVRLPzJiaILz NUXRXoo4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDESmNKOTF2IHPlcIx{KGW6cILld5NqdmdiRV3MOE1CVEtiR{GyOllCKG23dHHueEBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCOdX3pcoV{[2WwdDDD[YxtKF[rYXLpcIl1gSCDc4PhfUwhTUN3MDC9JFAvODF6IN88UU4> Mn;XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NkiyPFkoRjJ4NU[4Nlg6RC:jPh?=
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KARPAS299 M3;ncGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2DFTFIhfG9iMzDkZZl{ MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXJRSVN{OUmgZ4VtdHNiYX\0[ZIhOiC2bzCzJIRigXNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwJF0hOC5yMkK4JO69VS5? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd2MkK1Nkc,OjN5NEKyOVI9N2F-
KARPAS299 NH7UT2pEgXSxdH;4bYNqfHliYYPzZZk> M1f2XGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtCWlCDU{K5PUBk\WyuczDlfJBz\XO|aX7nJG5RVS2DTFug[pV{cW:wIHflcoUh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25uIFnDOVAhRSByLkCyNlgh|ryPLh?= NULUNGY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4N|c4QTdpPkKzPFM4Pzl5PD;hQi=>
NCI-H3122 NFu2bXhHfW6ldHnvckBie3OjeR?= Ml7SO|IhcHK| NFywZo5KdmirYnn0bY9vKG:oIFXNUFQh\nW|ZXSgRWxMKGmwIHj1cYFvKE6FST3IN|EzOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGNEPTBiPTCwMlAzPSEQvF2u NHHIbIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mxOVE3QSd-Mke5NVUyPjl:L3G+
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SU-DHL1 MV\GeY5kfGmxbjDhd5NigQ>? NEfxR|IzOCC2bzCyNFAhdk1? MX6xJIhz MmPxTY5pcWKrdHnvckBw\iCDTFugbY4hcHWvYX6gV3UuTEiOMTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hTVKNIIDoc5NxcG:{eXzheIlwdiCjdDDUNlAzNy:\MkC0JJJme2mmdXXzJIF1KDJyIITvJFIxOCCwTTDh[pRmeiBzIHjyJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= MnrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5OFAoRjJ7Mki4PVQxRC:jPh?=
NCI-H3122 NV7QS|F1TnWwY4Tpc44h[XO|YYm= MV:yNEB1dyB{MECgcm0> NIjiXpkyKGi{ M4jwb2lvcGmkaYTpc44hd2ZiQVzLJJBpd3OyaH;yfYxifGmxbjDheEB[OTJ5ODDy[ZNq\HWnIHnuJIh2dWGwIF7DTU1JOzF{MjDj[YxteyCjdDCyNEB1dyB{MECgcm0h[W[2ZYKgNUBpeiCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> M4PofVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQxLz5{OUK4PFk1ODxxYU6=
NCI-H3122 MkP5SpVv[3Srb36gZZN{[Xl? NWDvR|dCOjBidH:gNlAxKG6P NGLp[osyKGi{ NILkOGZKdmirYnn0bY9vKG:oIFHMT{BqdiCqdX3hckBPS0lvSEOxNlIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBifCC\N{C1JJJme2mmdXWgZZQhOjBidH:gNlAxKG6PIHHmeIVzKDFiaIKgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| M4HsPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQxLz5{OUK4PFk1ODxxYU6=
SU-DHL1 MX\GeY5kfGmxbjDhd5NigQ>? MkPHN|Ahdk1? MVuxOkBpenN? MY\Jcohq[mm2aX;uJI9nKEGOSzDheZRweGixc4Doc5J6dGG2aX;uJIF1KFlzNUC3JJJme2mmdXWgbY4hcHWvYX6gV3UuTEiOMTDj[YxteyCjdDCzNEBvVSCjZoTldkAyPiCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NWLrUnpbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2Nlc4OjVpPkK5OlI4PzJ3PD;hQi=>
SU-DHL1 MWrGeY5kfGmxbjDhd5NigQ>? MV:zNEBvVQ>? M4\XXFE3KGi{cx?= NYLRdVZuUW6qaXLpeIlwdiCxZjDBUGshcW5iaIXtZY4hW1VvRFjMNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iU2TBWFMheGixc4Doc5J6dGG2aX;uJIF1KFl5MEWgdoV{cWS3ZTDheEA{OCCwTTDh[pRmeiBzNjDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NWmxVGNYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2Nlc4OjVpPkK5OlI4PzJ3PD;hQi=>
NCI-H3122 NHzIT4xHfW6ldHnvckBie3OjeR?= MV61NEB1dyB{NUCgcm0> M4fkfVE3KGi{cx?= NIfIc|ZKdmS3Y4Tpc44hd2ZiQVzLJIRm\3KjZHH0bY9vKGmwIHj1cYFvKE6FST3IN|EzOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDBUGsheGixc4Doc5J6dGG2aX;uJIF1KFlzNkC0JIF1KDVyIITvJFI2OCCwTTDh[pRmeiBzNjDodpMh[nliaX3teY5w[myxdDDt[ZRpd2R? NYC2UWRFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OlA6QDRpPkK5OlYxQTh2PD;hQi=>
SH-SY5Y NVruZ2NVSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX2xUGRNPzJiaILz NV\xWm1lSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTTE1UYTW\IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6 MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ4MEm4OEc,Ojl4NkC5PFQ9N2F-
CHLA20 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXG3NkBpenN? M3jMXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1jMRVIxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG|c3H5 MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ4MEm4OEc,Ojl4NkC5PFQ9N2F-
SH-SY5Y M2izTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3vxNFczKGi{cx?= NV7rS|BSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTTE1UYTW\IHPlcIx{KGGodHXyJFczKGi{czDpckBxemW|ZX7j[UBw\iCDQlPCNUBqdmirYnn0c5IhfGG{aYH1bYRieiCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG|c3H5 NU\DOoNzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OlA6QDRpPkK5OlYxQTh2PD;hQi=>
KARPAS299 M2PtNGZ2dmO2aX;uJIF{e2G7 NXG0SY5GPTBidH:gNlUxKG6P M1LwUFE3KGi{cx?= NFPucVBKdmS3Y4Tpc44hd2ZiQVzLJIRm\3KjZHH0bY9vKGmwIHj1cYFvKEuDUmDBV|I6QSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDBUGsheGixc4Doc5J6dGG2aX;uJIF1KFlzNkC0JIF1KDVyIITvJFI2OCCwTTDh[pRmeiBzNjDodpMh[nliaX3teY5w[myxdDDt[ZRpd2R? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ4MEm4OEc,Ojl4NkC5PFQ9N2F-
CHLA20 NIXiR5JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmHKO|IhcHK| Moe0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFSFzBNlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGmwIIDy[ZNmdmOnIH;mJGFDS0JzIHnubIljcXSxcjD0ZZJqeXWrZHHyJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[Xl? NF;2cW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[2NFk5PCd-Mkm2OlA6QDR:L3G+
NCI-H3122 NVXqWVBPSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmT1O|IhcHK| M4XBbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg{OTJ{IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6 NW\USZNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OlA6QDRpPkK5OlYxQTh2PD;hQi=>
KARPAS299 NVmzcWFMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MU[3NkBpenN? NF7V[ZhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvBVnBCWzJ7OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDseY1qdmW|Y3XueEBk\WyuII\pZYJqdGm2eTDhd5NigQ>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ4MEm4OEc,Ojl4NkC5PFQ9N2F-
SU-DHL1 NGrQfmVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYL2WXFpPzJiaILz MmqyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVVT3ETGwyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG|c3H5 NGXrT489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[2NFk5PCd-Mkm2OlA6QDR:L3G+
KARPAS299 NVTUU|JKSXCxcITvd4l{KGG|c3H5 NFrpUFA2OCCwTR?= NFXkWWgzPCCqcoO= MYnJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEuDUmDBV|I6QSClZXzsd{Bie3Onc4Pl[EBieyC3bnPs[YFzKGOnbHygd4hzcW6tYXflJIF1KDVyIH7NJIFnfGW{IEK0JIhzeyCkeTDIc4VkcHO2IEOzNlU5KHO2YXnubY5oKGKjc3XkJIlvfmW{dHXkJIZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3C7 MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ{M{GyNEc,OzB{MkOxNlA9N2F-
KARPAS299 M17vWmFxd3C2b4Ppd{Bie3OjeR?= M{PlNVUxKG6P MVqyOEBpenN? MVLJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEuDUmDBV|I6QSClZXzsd{Bie3Onc4Pl[EBieyCuYYTlJIFxd3C2b4TpZ{Bk\WyuczDheEA2OCCwTTDh[pRmeiB{NDDodpMh[nliQV:vSWIh\G:3YnzlJJN1[WmwaX7nJIJie2WmIHnueoVzfGWmIH\seY9z\XOlZX7j[UBucWO{b4Pjc5B6 MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ{M{GyNEc,OzB{MkOxNlA9N2F-
KARPAS299 M2LOcWFxd3C2b4Ppd{Bie3OjeR?= MnuzOVAhdk1? MYSyOEBpenN? M3nGTGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS1HSVGFUOjl7IHPlcIx{KGG|c3Xzd4VlKGG|IH\yZYdu\W62YYTpc44h[XRiNUCgcm0h[W[2ZYKgNlQhcHK|IHL5JGhw\WOqc4SgN|MzPThic4ThbY5qdmdiYnHz[YQhcW64ZYL0[YQh\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcIm= MlLHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MkOxNlAoRjNyMkKzNVIxRC:jPh?=
Assay
Methods Test Index PMID
Western blot p-ALK / ALK / p-AKT / AKT / p-ERK / ERK pROS1 / ROS1 / pSTAT3 / STAT3 28425916 25351743
Growth inhibition assay Cell viability 29067644
体内研究 LDK378 用于降低形成反应代谢的可能性,在肝微粒体几乎检测不到谷胱甘肽(GSH)加合物的水平(<1%)。LDK378具有相对良好的代谢稳定性,中度抑制CYP3A4(Midazolam底物)和抑制hERG。LDK378处理动物,与肝脏血流量相比,具有低的血浆清除率(小鼠,大鼠,狗和猴),处理小鼠,大鼠,狗和猴的口服生物利用度都在55%以上。LDK378 处理Karpas299 和H2228 大鼠移植瘤模型,抑制肿瘤生长,诱导肿瘤衰退,这种作用具有剂量依赖性,体重没有降低。LDK378处理小鼠,剂量高达100 mg/kg,对胰岛素水平或血浆葡萄糖的利用无影响。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
  • 激酶分析:

    所有激酶使用杆状病毒表达技术表达为组氨酸或GST标签的融合蛋白,除了在大肠杆菌中产生的未标记的ERK2。在LabChip迁移实验中测量激酶活性。实验在30°C下进行60分钟。在有或无LDK378存在时,通过线性进展曲线,获得LDK378对酶活性的作用效果。

细胞实验:[1]
  • Cell lines: Ba/F3-NPM-ALK, Ba/F3-Tel-InsR, Ba/F3-WT, Karpas299 细胞
  • Concentrations: ~100 μM
  • Incubation Time: 2-3 天
  • Method: 表达荧光素酶的细胞与连续稀释的LDK378 或 DMSO 温育2-3天。荧光素酶的表达用来衡量细胞增殖/存活,使用Bright-Glo萤光素酶检测系统来评估。使用 XLFit软件获得 IC50值。
动物实验:[1]
  • Animal Models: 携带 Karpas299/H2228肿瘤的 RNU裸鼠
  • Dosages: ~50 mg/kg
  • Administration: 口服饲喂

溶解度(25°C)

体外

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 558.14
化学式

C28H36ClN5O3S

CAS号 1032900-25-6
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02450903 Completed Drug: LDK378 Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis August 21 2015 Phase 2
NCT02040870 Completed Drug: LDK378 Non-Small Cell Lung Cancer Novartis Pharmaceuticals|Novartis March 7 2014 Phase 1|Phase 2
NCT01950481 Completed Drug: LDK378 Normal Hepatic Function|Impaired Hepatic Function Novartis Pharmaceuticals|Novartis January 2014 Phase 1
NCT01772797 Completed Drug: LDK378|Drug: AUY922 Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01685060 Completed Drug: LDK378 Non-Small Cell Lung Cancer Novartis Pharmaceuticals|Novartis November 26 2012 Phase 2
NCT01634763 Completed Drug: LDK378 Tumors Characterized by Genetic Alterations in Anaplastic Lymphoma Kinase (ALK) Novartis Pharmaceuticals|Novartis June 2012 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技术支持

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操作手册

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常见问题及建议解决方法

问题 1:
how to reconstitute the inhibitor for oral administration to mice?

回答:
You can resuspend LDK378 in 30% PEG400/0.5% Tween 80/5% propylene glycol and use the suspension for oral gavage feeding.

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