Immunology & Inflammation related

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S2286 Cyclosporin A <1 mg/mL 100 mg/mL 100 mg/mL
S5004 Pimecrolimus <1 mg/mL 100 mg/mL 100 mg/mL
S1211 Imiquimod <1 mg/mL 1 mg/mL <1 mg/mL
S3032 Bindarit <1 mg/mL 64 mg/mL 64 mg/mL
S1407 Bimatoprost <1 mg/mL 36 mg/mL 83 mg/mL
S3774 Dehydroandrographolide Succinate Potasium Salt -1 mg/mL 10 mg/mL -1 mg/mL
S3775 Ligustrazine hydrochloride -1 mg/mL 34 mg/mL -1 mg/mL
S3758 Sinomenine hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S3932 Astilbin -1 mg/mL 100 mg/mL -1 mg/mL
S3837 Echinocystic acid -1 mg/mL 94 mg/mL -1 mg/mL
S3827 Royal jelly acid -1 mg/mL 37 mg/mL -1 mg/mL
S3841 Eleutheroside B -1 mg/mL 74 mg/mL -1 mg/mL
S3956 Tetramethylpyrazine -1 mg/mL 27 mg/mL -1 mg/mL
S3614 Lupeol <1 mg/mL 1 mg/mL <1 mg/mL
S3685 4-Biphenylacetic acid <1 mg/mL 42 mg/mL 42 mg/mL
S3680 NLRP3 Inflammasome Inhibitor I <1 mg/mL 73 mg/mL <1 mg/mL
S3745 Balsalazide disodium 87 mg/mL 87 mg/mL <1 mg/mL
S3648 Amlexanox <1 mg/mL 59 mg/mL 1 mg/mL
S3726 Selexipag <1 mg/mL 99 mg/mL 49 mg/mL
S3668 Thymopentin 100 mg/mL 100 mg/mL <1 mg/mL
S3622 Diammonium Glycyrrhizinate 100 mg/mL 100 mg/mL <1 mg/mL
S3608 Demethylzeylasteral (T-96) <1 mg/mL 96 mg/mL 33 mg/mL
S4753 Ganoderic acid A <1 mg/mL 100 mg/mL 100 mg/mL
S8522 Compstatin 100 mg/mL -1 mg/mL -1 mg/mL
S8141 Cl-amidine 70 mg/mL 84 mg/mL 84 mg/mL
S8291 Atractylenolide I <1 mg/mL 46 mg/mL 46 mg/mL
S1439 Tranilast <1 mg/mL 66 mg/mL <1 mg/mL
S1737 Prednisolone <1 mg/mL 72 mg/mL 10 mg/mL
S1622 Prednisone <1 mg/mL 71 mg/mL <1 mg/mL
S4169 Teriflunomide <1 mg/mL 32 mg/mL ,1 mg/mL
S2413 Geniposidic acid <1 mg/mL 16 mg/mL 2 mg/mL
S1508 Alprostadil <1 mg/mL 71 mg/mL 71 mg/mL
S1733 Methylprednisolone <1 mg/mL 75 mg/mL 2 mg/mL
S1939 (-)-Tetramisole 48 mg/mL <1 mg/mL <1 mg/mL
S2787 Laquinimod <1 mg/mL 61 mg/mL 1 mg/mL
S1681 Mesalamine <1 mg/mL 31 mg/mL 31 mg/mL
S2910 Tempol 34 mg/mL 34 mg/mL 34 mg/mL
S1679 Flurbiprofen <1 mg/mL 49 mg/mL 49 mg/mL
S1829 Pranlukast <1 mg/mL 11 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S1576 Sulfasalazine <1 mg/mL 80 mg/mL <1 mg/mL
S1654 Phenylbutazone <1 mg/mL 62 mg/mL 62 mg/mL
S2512 Tenoxicam <1 mg/mL 68 mg/mL <1 mg/mL
S3062 Diclofenac Potassium 10 mg/mL 69 mg/mL <1 mg/mL
S7515 VGX-1027 <1 mg/mL 41 mg/mL 41 mg/mL
S4098 Halcinonide <1 mg/mL 90 mg/mL 4 mg/mL
S1823 Fenoprofen Calcium <1 mg/mL 105 mg/mL 10 mg/mL
S8301 AS101 <1 mg/mL 62 mg/mL <1 mg/mL
S4268 Flufenamic acid <1 mg/mL 56 mg/mL 56 mg/mL
S4529 Idramantone 33 mg/mL 33 mg/mL 33 mg/mL
S7211 PF-04418948 <1 mg/mL 81 mg/mL <1 mg/mL
S4152 Ethamsylate 53 mg/mL 53 mg/mL <1 mg/mL
S4165 Benzydamine HCl 69 mg/mL 69 mg/mL 69 mg/mL
S4170 Coumarin <1 mg/mL 29 mg/mL 29 mg/mL
S7809 MCC950(CP-456773) 85 mg/mL <1 mg/mL 40 mg/mL
S2400 Rheic Acid <1 mg/mL <1 mg/mL <1 mg/mL
S4188 Sasapyrine <1 mg/mL 52 mg/mL 52 mg/mL
S7448 CORM-3 <1 mg/mL 38 mg/mL <1 mg/mL
S4682 Loxoprofen <1 mg/mL 49 mg/mL 49 mg/mL
S7516 Y-320 <1 mg/mL 11 mg/mL <1 mg/mL
S3027 Fenoprofen calcium hydrate <1 mg/mL 48 mg/mL 18 mg/mL
S8097 C-DIM12 <1 mg/mL 71 mg/mL 71 mg/mL
S2350 Rutin <1 mg/mL 100 mg/mL 2 mg/mL
S7434 TAPI-1 60 mg/mL 99 mg/mL 99 mg/mL
S4690 Escin <1 mg/mL 66 mg/mL <1 mg/mL
产品目录 产品描述 文献引用 实验数据
S2286

Cyclosporin A

Cyclosporin A是一种免疫抑制剂,与亲环素结合,随后抑制calcineurin,无细胞试验中IC50为7 nM,广泛用于预防器官移植反应中的排斥反应。

S5004

Pimecrolimus

Pimecrolimus是一种抑免蛋白配体, 可以特异地与胞质受体macrophilin-12结合;是钙调蛋白抑制剂。

S1211

Imiquimod

Imiquimod 是新型合成的药剂,具有免疫反应修饰活性。

S3032

Bindarit

Bindarit是天然化合物,具有特定抗炎活性,因为选择性抑制炎症趋化因子亚家族,包括单核细胞趋化蛋白MCP-1/CCL2, MCP-3/CCL7, 和 MCP-2/CCL8。

S1407

Bimatoprost

Bimatoprost是一种前列腺素类似物,局部(眼药水)用药,治疗青光眼和高眼压症。

S3774New

Dehydroandrographolide Succinate Potasium Salt

Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.

S3775New

Ligustrazine hydrochloride

Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

S3758New

Sinomenine hydrochloride

Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.

S3932New

Astilbin

Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

S3871New

Muscone

Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.

S3837New

Echinocystic acid

Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.

S3893New

Bornyl acetate

Bornyl acetate, the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibit anti-inflammatory property and it is used as an analgesic.

S3827New

Royal jelly acid

Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

S3841New

Eleutheroside B

Eleutheroside B (syringin) is a phenylpropanoid glycoside first isolated from A. senticosus that has neuroprotective, tonic, adaptogenic, and immune-modulating properties.

S3956New

Tetramethylpyrazine

Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

S3614New

Lupeol

Lupeol is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.

S3685New

4-Biphenylacetic acid

4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.

S3680New

NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.

S3745New

Balsalazide disodium

Balsalazide Disodium是balsalazide的二钠盐形式,balsalazide是一种口服的对氨水杨酸钠前体药物,在结肠中被酶解、产生抗炎性的美沙拉秦(mesalazine)。

S3648New

Amlexanox

Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.

S3726New

Selexipag

Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).

S3668New

Thymopentin

Thymopentin has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.

A2009New

Rituximab

Rituximab是嵌合的anti-CD20单克隆抗体,与B细胞上的CD20抗原结合,结合亲和力为5 nM。MW: 143.86 KD。

S3622New

Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate (DG)是一种传统的中草药,从甘草中提取纯化而来。它具有抗炎活性,对生物氧化具有抗性、对膜具有保护性。DG通过抑制NF-κB、TNF-α和细胞间黏附分子1来减少炎症损伤。

S3608New

Demethylzeylasteral (T-96)

Demethylzeylasteral (T-96)是从Tripterygium wilfordii Hook F.中分离出的活性成分,能够抑制UDP-glucuronosyltransferase (UGT)的亚型UGT1A6UGT2B7,具有免疫抑制活性。

S8559New

INF39

INF39是NLRP3的无毒性的、不可逆的抑制剂,通过与NLRP3不可逆地直接相互作用以及部分抑制LPS驱动的促炎性基因表达,阻止NLRP3的激活。

A2001New

Ipilimumab

Ipilimumab是一种免疫调节单克隆抗体,靶向细胞表面抗原CTLA-4;也是一种免疫检查点抑制剂;MW:148 KD。

S4753New

Ganoderic acid A

Ganoderic acid A (GAA),是Ganoderma lucidum中具有活性的三萜系化合物,具有镇痛、抗氧化、细胞毒性、保护肝脏和抗肿瘤活性。

S8522New

Compstatin

Compstatin与complement component C3结合,抑制补体激活,IC50为1.2 μM。

S8141New

Cl-amidine

Cl-amidine是一种不可逆地泛peptidylarginine deiminase (PAD)抑制剂,对PAD4、PAD1和PAD3的IC50值分别为5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM。

S8291New

Atractylenolide I

Atractylenolide I 是A. macrocephala根茎的主要类倍半萜烯类化合物。具有广谱的药理活性,如抗炎、促消化、抗氧化作用。

S1439

Tranilast

Tranilast是一种抗过敏化合物。

S1737

Prednisolone

Prednisolone 是一种人工合成的糖皮质激素,具有抗炎和免疫调节特性。

S1622

Prednisone

Prednisone 是一种人工合成的皮质类固醇剂,是特别有效的免疫抑制剂的化合物。

S4169

Teriflunomide

Teriflunomide是Leflunomide的活性代谢物,通过抑制酶二氢乳清酸脱氢酶,从而抑制嘧啶从头合成,作为一种免疫调节剂。

S2413

Geniposidic acid

Geniposidic acid 是一种环烯醚萜类糖苷,用于治疗炎症,黄疸以及肝病。

S1508

Alprostadil

Alprostadil 用于治疗勃起功能障碍,具有血管舒张的特性。它是前列腺素的类似物,是Prostaglandin E1的激动剂。

S1733

Methylprednisolone

Methylprednisolone 是一种人工合成的皮质类固醇,具有抗炎和免疫调节特性。

S1939

(-)-Tetramisole

(-)-Tetramisole是一种驱虫药物,已经尝试用于治疗风湿性疾病通过增加巨噬细胞的趋化性和T-淋巴细胞的功能显著恢复免疫应答。

S2787

Laquinimod

Laquinimod是有效的免疫调节剂。Phase 3。

S1681

Mesalamine

Mesalamine是一种抗炎化合物。

S2910

Tempol

Tempol是一种超氧化物清除剂,具有神经保护,抗炎症和镇痛效果。Phase 2

S1679

Flurbiprofen

Flurbiprofen 是一种苯基烷酸衍生物,是非甾体类抗炎药(NSAIDs)。

S1829

Pranlukast

Pranlukast 是一种选择性白三烯受体拮抗剂。

S1514

Cyclosporine

Cyclosporine 是一种钙调酶抑制剂,用作免疫抑制剂药物来组织器官移植中的免疫排斥。

S1576

Sulfasalazine

Sulfasalazine 是一种磺胺剂,是Mesalazine的衍生物,主要用作抗炎剂。

S1654

Phenylbutazone

Phenylbutazone 是一种非甾体抗炎剂,用于治疗慢性疼痛,包括关节炎的症状。

S2512

Tenoxicam

Tenoxicam是一种有效的自由基清除剂,IC50为56.7 μM。

S3062

Diclofenac Potassium

Diclofenac Potassium是一种非类固醇消炎药,用于减轻炎症和某些状况下的止痛药。

S7515

VGX-1027

VGX-1027 是一种口服有效的免疫调节剂。 Phase 1。

S4098

Halcinonide

Halcinonide是一种高效的皮质类固醇,用作局部制剂,作为抗炎剂。

S1823

Fenoprofen Calcium

Fenoprofen Calcium是一种非甾体类,抗炎,抗关节炎药剂。

S8301

AS101

AS101,一种有效的体内体外免疫调节剂,是新型的IL-1beta转化酶的抑制剂。

S4268

Flufenamic acid

Flufenamic acid 是一种非甾体抗炎药物,离子通道调节剂。

S4529

Idramantone

Idramantone是一种免疫激动剂。

S7211

PF-04418948

PF-04418948 是一种有效的选择性前列腺素 EP₂ receptor 拮抗剂,IC50 为 16 nM。Phase 1.

S4152

Ethamsylate

Ethamsylate是一种止血药,抑制前列腺素的生物合成和功能,提高毛细血管内皮阻力和血小板粘附。

S4165

Benzydamine HCl

Benzydamine HCl 是一种外用的非甾体抗炎药(NSAID),具有抗炎,镇痛,解热和局部麻醉剂的活性。

S4170

Coumarin

Coumarin是植物化学成分,具有肝毒性和致癌性。

S7809

MCC950(CP-456773)

MCC950(CP-456773)是一种有效的、选择性NLRP3抑制剂,在骨髓来源的巨噬细胞中IC50为7.5 nM。对AIM2, NLRC4或NLRP1炎症体没有作用。

S2400

Rheic Acid

Rheic Acid 是Rhubarb的组成部分,是从Rheum coreanum Nakai新鲜根茎分离得到的。

S4188

Sasapyrine

Sasapyrine是一种口服的非甾体类抗炎药。

S7448

CORM-3

CORM-3 是水溶性一氧化碳的释放分子,具有抗炎和保护心脏的作用。

S4682

Loxoprofen

Loxoprofen是非类固醇的消炎药,属于丙酸衍生物。

S7516

Y-320

Y-320 是一种口服有效的 immunomodulator, 它通过 CD4 T 细胞刺激 IL-15 从而抑制IL-17的产生,其IC50为20到60 nM。

S3027

Fenoprofen calcium hydrate

Fenoprofen calcium hydrate是一种非甾类抗炎症药物(NSAID)。

S4706

Eugenol

Eugenol是一种自然存在的香味化合物,发现于丁香油和其他植物中。Eugenol通过增加组胺释放和细胞免疫发挥其生理作用。

S8097

C-DIM12

C-DIM12是Nurr1的激活剂,刺激膀胱癌细胞和肿瘤中Nurr1所介导的细胞凋亡、抑制胶质细胞中对NF-κB依赖的基因表达。

S4709

Latanoprost

Latanoprost是前列腺素F2α的类似物,是前列腺素类选择性FP受体的激动剂。Latanoprost增加葡萄膜巩膜外流,因而减少眼压。

S2350

Rutin

Rutin是在许多植物中发现的一种黄酮苷,包括Buckwheat; Tobacco; Forsythia; Hydrangea; Viola, 等。

S7434

TAPI-1

TAPI-1 是一种ADAM17/TACE抑制剂, 其对细胞因子受体有抑制作用。

S4690

Escin

Escin是在欧洲七叶树中所发现的皂苷混合物,具有抗炎、血管收缩的、血管保护作用。

S4524

2-Ethoxybenzamide

2-Ethoxybenzamide是一种常见的止痛剂和消炎药,用于缓解发热发烧、头痛和其他的轻微疼痛。

产品目录 产品描述 文献引用 实验数据
A5236New

IRF1 Rabbit Recombinant mAb

A5289New

L1CAM Rabbit Recombinant mAb