Lipase

抑制剂选择性比较

Lipase产品

所有产品(12) Lipase抑制剂(11)

目录号	产品描述	文献引用	实验数据
S1629	Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。	Nat Cell Biol, 2022, 24(3):364-372 Nat Commun, 2021, 12(1):3830 Cell Rep, 2021, 36(12):109742
S4904	JZL184 JZL 184 是第一个选择性的Monoacylglycerol lipase (MAGL)（单酰基甘油脂肪酶）抑制剂，IC50为8 nM。	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Biomed Pharmacother, 2022, 149:112798 Open Biol, 2021, 11(2):200306
S7364	Atglistatin Atglistatin 是一种高度选择性adipose triglyceride lipase (ATGL)抑制剂，其IC50为0.7 μM.	Nat Commun, 2021, 12(1):3493 EMBO Rep, 2020, 21(12):e49634 J Cardiovasc Pharmacol Ther, 2020, 1074248420971113	C, G0s2-null MEFs were transfected with HRAS and the following day treated with either 40 mmol/L of ATGL inhibitor atglistatin or DMSO (Vehicle) every 2 days. Left, representative plates. Right, the average of biologic triplicate determinations. Error bars, SD. The experiment was repeated twice with similar results.
S7457	XEN445 XEN445 是一种有效的选择性 endothelial lipase 抑制剂，IC50为0.237 μM。
S9234	Schaftoside Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
S6609	JZL195 JZL195是有效的FAAH和MAGL抑制剂，IC50分别为2 nM和4 nM。
S6550	URB602 URB602是单酰基甘油脂酶(MGL)抑制剂。
S9404	Pristimerin Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon.	Cell Death Dis, 2020, 14;11(4):232
S8823	ABX-1431 ABX-1431是一种有效的、选择性、能穿透中枢神经系统的单酰基甘油脂酶(MGLL)抑制剂，对人源MGLL和鼠源MGLL的IC50值分别为14 nM和27 nM。
S2365	Tanshinone IIA Tanshinone IIA (Tanshinone B) 是丹参和Salviae miltiorrhizae Radix中最丰富的二萜醌类，用于治疗心血管疾病和炎症性疾病。是天然的monoacylglycerol lipase抑制剂。	Biochem Biophys Res Commun, 2021, 575:1-7 Mol Med Rep, 2021, 23(5)371 Front Pharmacol, 2020, 11:586616	Western blotting analysis of b-catenin, TCF3 and LEF1 levels in HT-29 cells. b-actin is the loading control.
S4930	Cetilistat Cetilistat (ATL962)是一种高度亲脂性苯并恶嗪酮，抑制肠胃和胰脏脂酶（lipases）。在体内，它具有良好的安全性和耐受性。
S4825	Pancreatin Pancreatin (Pancrelipase, Pancreatic enzymes)是淀粉酶、脂肪酶和蛋白酶商品化混合物。它们被用于治疗由于胰腺问题导致的吸收障碍综合征。

目录号	产品描述	文献引用	实验数据
S1629	Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。	Nat Cell Biol,2022, 24(3):364-372 Nat Commun,2021, 12(1):3830 Cell Rep,2021, 36(12):109742
S4904	JZL184 JZL 184 是第一个选择性的Monoacylglycerol lipase (MAGL)（单酰基甘油脂肪酶）抑制剂，IC50为8 nM。	Nat Chem Biol,2022, 10.1038/s41589-022-00996-7 Biomed Pharmacother,2022, 149:112798 Open Biol,2021, 11(2):200306
S7364	Atglistatin Atglistatin 是一种高度选择性adipose triglyceride lipase (ATGL)抑制剂，其IC50为0.7 μM.	Nat Commun,2021, 12(1):3493 EMBO Rep,2020, 21(12):e49634 J Cardiovasc Pharmacol Ther,2020, 1074248420971113	C, G0s2-null MEFs were transfected with HRAS and the following day treated with either 40 mmol/L of ATGL inhibitor atglistatin or DMSO (Vehicle) every 2 days. Left, representative plates. Right, the average of biologic triplicate determinations. Error bars, SD. The experiment was repeated twice with similar results.
S7457	XEN445 XEN445 是一种有效的选择性 endothelial lipase 抑制剂，IC50为0.237 μM。
S9234	Schaftoside Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
S6609	JZL195 JZL195是有效的FAAH和MAGL抑制剂，IC50分别为2 nM和4 nM。
S6550	URB602 URB602是单酰基甘油脂酶(MGL)抑制剂。
S9404	Pristimerin Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon.	Cell Death Dis,2020, 14;11(4):232
S8823	ABX-1431 ABX-1431是一种有效的、选择性、能穿透中枢神经系统的单酰基甘油脂酶(MGLL)抑制剂，对人源MGLL和鼠源MGLL的IC50值分别为14 nM和27 nM。
S2365	Tanshinone IIA Tanshinone IIA (Tanshinone B) 是丹参和Salviae miltiorrhizae Radix中最丰富的二萜醌类，用于治疗心血管疾病和炎症性疾病。是天然的monoacylglycerol lipase抑制剂。	Biochem Biophys Res Commun,2021, 575:1-7 Mol Med Rep,2021, 23(5)371 Front Pharmacol,2020, 11:586616	Western blotting analysis of b-catenin, TCF3 and LEF1 levels in HT-29 cells. b-actin is the loading control.
S4930	Cetilistat Cetilistat (ATL962)是一种高度亲脂性苯并恶嗪酮，抑制肠胃和胰脏脂酶（lipases）。在体内，它具有良好的安全性和耐受性。

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产品描述

文献引用

实验数据

S4825

Pancreatin

Pancreatin (Pancrelipase, Pancreatic enzymes)是淀粉酶、脂肪酶和蛋白酶商品化混合物。它们被用于治疗由于胰腺问题导致的吸收障碍综合征。