Beta Amyloid
Beta Amyloid产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2215 |
DAPT (GSI-IX)DAPT (GSI-IX, LY-374973) 是一种新型γ-secretase抑制剂,抑制 Aβ产生,在HEK 293细胞中IC50为20 nM。DAPT可促进人类舌癌细胞的凋亡并调节自噬。 |
![]() ![]() Western blotting showing increased unconjugated SUMO1 levels in Notch1 ΔE cells treated with 10 uM DAPT for 3 days. Tubulin was used as a loading control.
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S1575 |
RO4929097RO4929097 (RG-4733)是一种γ secretase抑制剂,无细胞试验中IC50为4 nM,抑制Aβ40和Notch的细胞加工,EC50分别为14 nM和5 nM。Phase 2。 |
![]() ![]() |
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S1594 |
Semagacestat (LY450139)Semagacestat (LY450139)是一种γ-分泌酶抑制剂,作用于Aβ42,Aβ40和Aβ38,IC50分别为10.9 nM,12.1 nM和12.0 nM,也抑制Notch信号通路,人神经胶质瘤细胞中IC50为14.1 nM。Phase 3。 |
![]() ![]() HEK/APPswe cells were either left non-treated (-) or exposed to the γ-secretase inhibitor (GSI) semagacestat (+) for 19 h prior to cell harvesting and membrane preparation (Substrate accumulation). Exposure of cells with GSI prior to membrane preparation results in higher Aβ1-42 and Aβx-42 signals as compared to membranes derived from non-GSI treated cells. Direct addition of semagacestat to the membranes in the novo Aβ production assay inhibited Aβ production (Semagacestat (1 µM)). The amount of Aβx-42 is higher than Aβ1-42 suggesting that C83 is the major substrate for the Aβ42 signal detected. |
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S2660 |
MK-0752MK-0752是一种适度有效的γ-secretase(γ-分泌酶)抑制剂,降低Aβ40产量,IC50为5 nM。Phase 1/2。 |
![]() ![]() HES1 expression after treatment with clinically available GSIs R04929097, BMS-708163, LY450139, and MK-0752 as determined by qRT-PCR.
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S1262 |
Avagacestat (BMS-708163)Avagacestat (BMS-708163)是口服生物有效的,选择性的γ-分泌酶抑制剂,作用于Aβ40和Aβ42时,IC50分别为0.3 nM和0.27 nM,比作用于Notch选择性高193倍。Phase 2。 |
![]() ![]() A panel of GICs lines was treated with various concentrations of γ secretase inhibitors BMS-708163. Cells were treated with increasing concentrations of γ secretase inhibitors in triplicate wells for 72 hours, and cell viability was assessed by CellTiter-Blue assay as described in Materials and Methods. The results shown are of a single experiment with three independent replicates cell viability was measured by CellTiter-Blue assay. The graph depicts cell viability at 72 hours. Cell viability in the vehicle control was considered as to be 100%. |
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S1528 |
LY2811376LY2811376是第一个口服有效的,非肽类β-secretase(BACE1)抑制剂,IC50为239 nM-249 nM,可以减少Aβ分泌,EC50为300 nM,作用于BACE1比作用于BACE2选择性高10倍,比作用于其他天冬氨酸蛋白酶(包括Cathepsin D,胃蛋白酶和肾素)抑制效果高50倍以上。Phase 1。 |
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S0529 |
PBD-150PBD-150 是一种有效的人谷氨酰胺酰环化酶 (human glutaminyl cyclase,hQC) Y115E-Y117E 变异抑制剂,Ki 为 60 nM。 |
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S4261 |
EUK 134EUK 134是一种合成的超氧化物歧化酶(SOD)/过氧化氢酶类似物,具有强效的抗氧化活性,且抑制β-amyloid(β-淀粉样蛋白)和相关的淀粉样纤维形成。 |
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S4760 |
(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin), a well-known sugar used in drug delivery, genetic vector, environmental protection and treatment of Niemann-Pick disease type C1 (NPC1), is an inhibitor of amyloid-β aggregation. |
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S8185 |
FPS-ZM1FPS-ZM1是一种能透过血脑障壁、无毒性、三级酰胺化合物。是RAGE的特异性抑制剂,抑制Aβ与RAGE的V区域结合。 |
![]() ![]() FPS-ZM1 suppresses S100B promoted migration and invasion abilities. *P < 0.05, **P < 0.01 vs “CM” groups; &P < 0.05, &&P < 0.01 vs “S100B+FPS” groups. |
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S5101 |
Tabersonine hydrochlorideTabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity. |
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S9664 |
ColivelinColivelin (CLN) 是一种脑渗透性的神经保护肽,对神经退行性疾病中的 Aβ 沉积,神经元凋亡和突触可塑性缺陷具有有效的长期作用。 Colivelin 是一种 STAT3 的激活剂。 |
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S9087 |
TenuifolinTenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production. |
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S6733 |
Edonerpic maleateEdonerpic maleate (T-817)是一种神经营养性因子,可抑制amyloid-β peptides (Aβ)。 |
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S3811 |
Ginsenoside ReGinsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc)是三七的提取物、人参中的主要人参皂苷,属于20(S)-原人参三醇组 (protopanaxatriol group)。它具有多种体外和体内作用,包括血管舒张作用,抗氧化剂,抗高血脂和血管生成作用。Ginsenoside Re 会降低 β-amyloid protein (Aβ) 并通过抑制 JNK 和 NF-κB 起到抗炎的作用。 |
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S2418 |
FrentizoleFrentizole (Frentizol)是一种新型 amyloid beta peptide (Abeta) 结合 alcohol dehydrogenase (ABAD) 相互作用的抑制剂,IC50为200μM。Frentizole是一种无毒的抗病毒和免疫抑制剂,临床上用于类风湿关节炎和系统性红斑狼疮。 |
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S5742 |
Deferoxamine mesylate (Ba 33112)Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468)是Deferoxamine的甲磺酸盐,它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂,可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。 |
||
S3923 |
Ginsenoside Rg1Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1)是人参的主要活性成分之一,被确定为原人参三醇型,对多种癌症具有药理作用,例如神经保护和抗肿瘤作用。Ginsenoside Rg1 可降低 cerebral Aβ 水平并减少 NF-κB 核转移。 |
||
S0486 |
Hoechst 34580Hoechst 34580 (HOE 34580) 是一种具有细胞渗透性的蓝色荧光染料,用于染色DNA和细胞核。Hoechst 34580 也是一种治疗阿尔茨海默病的良好候选者,通过抑制 amyloid beta (Aβ) 的形成,其IC50值为0.86 μM。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2215 |
DAPT (GSI-IX)DAPT (GSI-IX, LY-374973) 是一种新型γ-secretase抑制剂,抑制 Aβ产生,在HEK 293细胞中IC50为20 nM。DAPT可促进人类舌癌细胞的凋亡并调节自噬。 |
![]() ![]() Western blotting showing increased unconjugated SUMO1 levels in Notch1 ΔE cells treated with 10 uM DAPT for 3 days. Tubulin was used as a loading control.
|
|
S1575 |
RO4929097RO4929097 (RG-4733)是一种γ secretase抑制剂,无细胞试验中IC50为4 nM,抑制Aβ40和Notch的细胞加工,EC50分别为14 nM和5 nM。Phase 2。 |
![]() ![]() |
|
S1594 |
Semagacestat (LY450139)Semagacestat (LY450139)是一种γ-分泌酶抑制剂,作用于Aβ42,Aβ40和Aβ38,IC50分别为10.9 nM,12.1 nM和12.0 nM,也抑制Notch信号通路,人神经胶质瘤细胞中IC50为14.1 nM。Phase 3。 |
![]() ![]() HEK/APPswe cells were either left non-treated (-) or exposed to the γ-secretase inhibitor (GSI) semagacestat (+) for 19 h prior to cell harvesting and membrane preparation (Substrate accumulation). Exposure of cells with GSI prior to membrane preparation results in higher Aβ1-42 and Aβx-42 signals as compared to membranes derived from non-GSI treated cells. Direct addition of semagacestat to the membranes in the novo Aβ production assay inhibited Aβ production (Semagacestat (1 µM)). The amount of Aβx-42 is higher than Aβ1-42 suggesting that C83 is the major substrate for the Aβ42 signal detected. |
|
S2660 |
MK-0752MK-0752是一种适度有效的γ-secretase(γ-分泌酶)抑制剂,降低Aβ40产量,IC50为5 nM。Phase 1/2。 |
![]() ![]() HES1 expression after treatment with clinically available GSIs R04929097, BMS-708163, LY450139, and MK-0752 as determined by qRT-PCR.
|
|
S1262 |
Avagacestat (BMS-708163)Avagacestat (BMS-708163)是口服生物有效的,选择性的γ-分泌酶抑制剂,作用于Aβ40和Aβ42时,IC50分别为0.3 nM和0.27 nM,比作用于Notch选择性高193倍。Phase 2。 |
![]() ![]() A panel of GICs lines was treated with various concentrations of γ secretase inhibitors BMS-708163. Cells were treated with increasing concentrations of γ secretase inhibitors in triplicate wells for 72 hours, and cell viability was assessed by CellTiter-Blue assay as described in Materials and Methods. The results shown are of a single experiment with three independent replicates cell viability was measured by CellTiter-Blue assay. The graph depicts cell viability at 72 hours. Cell viability in the vehicle control was considered as to be 100%. |
|
S1528 |
LY2811376LY2811376是第一个口服有效的,非肽类β-secretase(BACE1)抑制剂,IC50为239 nM-249 nM,可以减少Aβ分泌,EC50为300 nM,作用于BACE1比作用于BACE2选择性高10倍,比作用于其他天冬氨酸蛋白酶(包括Cathepsin D,胃蛋白酶和肾素)抑制效果高50倍以上。Phase 1。 |
![]() ![]() |
|
S0529 |
PBD-150PBD-150 是一种有效的人谷氨酰胺酰环化酶 (human glutaminyl cyclase,hQC) Y115E-Y117E 变异抑制剂,Ki 为 60 nM。 |
||
S4261 |
EUK 134EUK 134是一种合成的超氧化物歧化酶(SOD)/过氧化氢酶类似物,具有强效的抗氧化活性,且抑制β-amyloid(β-淀粉样蛋白)和相关的淀粉样纤维形成。 |
||
S4760 |
(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin), a well-known sugar used in drug delivery, genetic vector, environmental protection and treatment of Niemann-Pick disease type C1 (NPC1), is an inhibitor of amyloid-β aggregation. |
||
S8185 |
FPS-ZM1FPS-ZM1是一种能透过血脑障壁、无毒性、三级酰胺化合物。是RAGE的特异性抑制剂,抑制Aβ与RAGE的V区域结合。 |
![]() ![]() FPS-ZM1 suppresses S100B promoted migration and invasion abilities. *P < 0.05, **P < 0.01 vs “CM” groups; &P < 0.05, &&P < 0.01 vs “S100B+FPS” groups. |
|
S5101 |
Tabersonine hydrochlorideTabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity. |
||
S9664 |
ColivelinColivelin (CLN) 是一种脑渗透性的神经保护肽,对神经退行性疾病中的 Aβ 沉积,神经元凋亡和突触可塑性缺陷具有有效的长期作用。 Colivelin 是一种 STAT3 的激活剂。 |
||
S9087 |
TenuifolinTenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production. |
||
S6733 |
Edonerpic maleateEdonerpic maleate (T-817)是一种神经营养性因子,可抑制amyloid-β peptides (Aβ)。 |
||
S3811 |
Ginsenoside ReGinsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc)是三七的提取物、人参中的主要人参皂苷,属于20(S)-原人参三醇组 (protopanaxatriol group)。它具有多种体外和体内作用,包括血管舒张作用,抗氧化剂,抗高血脂和血管生成作用。Ginsenoside Re 会降低 β-amyloid protein (Aβ) 并通过抑制 JNK 和 NF-κB 起到抗炎的作用。 |
||
S2418 |
FrentizoleFrentizole (Frentizol)是一种新型 amyloid beta peptide (Abeta) 结合 alcohol dehydrogenase (ABAD) 相互作用的抑制剂,IC50为200μM。Frentizole是一种无毒的抗病毒和免疫抑制剂,临床上用于类风湿关节炎和系统性红斑狼疮。 |
||
S5742 |
Deferoxamine mesylate (Ba 33112)Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468)是Deferoxamine的甲磺酸盐,它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂,可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。 |
||
S3923 |
Ginsenoside Rg1Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1)是人参的主要活性成分之一,被确定为原人参三醇型,对多种癌症具有药理作用,例如神经保护和抗肿瘤作用。Ginsenoside Rg1 可降低 cerebral Aβ 水平并减少 NF-κB 核转移。 |
||
S0486 |
Hoechst 34580Hoechst 34580 (HOE 34580) 是一种具有细胞渗透性的蓝色荧光染料,用于染色DNA和细胞核。Hoechst 34580 也是一种治疗阿尔茨海默病的良好候选者,通过抑制 amyloid beta (Aβ) 的形成,其IC50值为0.86 μM。 |