Histone Acetyltransferase
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7152 | C646 | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| S1848 | Curcumin | <1 mg/mL | 73 mg/mL | <1 mg/mL |
| S7582 | Anacardic Acid | <1 mg/mL | 69 mg/mL | 69 mg/mL |
| S7641 | Remodelin | <1 mg/mL | 72 mg/mL | <1 mg/mL |
| S7476 | MG149 | <1 mg/mL | 68 mg/mL | 68 mg/mL |
- Histone Acetyltransferase抑制剂（5）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7152 |
C646C646是一种histone acetyltransferase抑制剂，抑制p300，无细胞试验中Ki为400 nM，相比于其它乙酰转移酶，优先作用于p300。 |
Phosphorylation of STAT6 in butyrate-treated M2-BMDMs. Western blotting was performed with anti-phospho-STAT6, STAT6, and β-actin. Data are representative of three independent experiments. M2:M2 macrophage; But:butyrate.
|
|
| S1848 |
CurcuminCurcumin 是流行的印度香料姜黄的主要姜黄色素，属于姜科（Zingiberaceae）。它是p300 histone acetylatransferase（IC50~25 μM）和Histone deacetylase的抑制剂，能够激活Nrf2 pathway并抑制NF-κB的激活。 |
Effect of NC1, NC1-CUR, NC2 and NC2-CUR on SH-SY5Y cell viability. The cells were treated for 24 h with different dilutions(1:1, 1:2 and 1:4) of empty nanocapsules (NC1 and NC2) and nanocapsules containing curcumin (NC1-CUR and NC2-CUR) followed by measurement of cell viability by MTT reduction assay (panel A) and cell toxicity by LDH release assay (panel B). Data after normalization to vehicle-treated cells (100%, MTT assay) or to total LDH release (TritonX100-treated cells, 100%) are presented as a mean±SEM from 3-8 independent experiments with five replicates. *p < 0.05, **p < 0.01 and ***p<0.001 versus vehicle-treated cells; &&&p<0.001 NC1 versus NC1-CUR.
|
|
| S7582 |
Anacardic AcidAnacardic Acid是一个有效的p300及p300/CBP相关因子 histone acetyltranferases的抑制剂，也具有抗细菌和抗微生物活性，抑制前列腺素合成，并抑制酪氨酸酶和脂肪氧合酶。 |
Western blot analysis of α-SMA expression in whole-lung lysates. Data are expressed as means ± SEM, *P < 0.05 versus vehicle and #P < 0.05 versus PQ (n = 4-6).
|
|
| S7641 |
RemodelinRemodelin是一种有效的acetyl-transferase NAT10抑制剂。 |
||
| S7476 |
MG149MG149 是强效的histone acetyltransferase抑制剂，其作用于Tip60和MOF的IC50分别为74 μM 和 47 μM。 |
