Histone Acetyltransferase

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研究领域

抑制剂选择性比较

Histone Acetyltransferase产品

所有产品 Histone Acetyltransferase抑制剂(9) 新Histone Acetyltransferase产品

产品目录	产品描述	文献引用	实验数据
S7152	C646 C646是一种histone acetyltransferase抑制剂，抑制p300，无细胞试验中K_i为400 nM，相比于其它乙酰转移酶，优先作用于p300。	Cell Metab, 2019, 29(4):886-900 Immunity, 2019, 51(6):997-1011 Mol Cell, 2019, 74(6):1250-1263	Phosphorylation of STAT6 in butyrate-treated M2-BMDMs. Western blotting was performed with anti-phospho-STAT6, STAT6, and β-actin. Data are representative of three independent experiments. M2:M2 macrophage; But:butyrate.
S1848	Curcumin Curcumin 是流行的印度香料姜黄的主要姜黄色素，属于姜科（Zingiberaceae）。它是p300 histone acetylatransferase（IC50~25 μM）和Histone deacetylase的抑制剂，能够激活Nrf2 pathway并抑制NF-κB的激活。	Biochim Biophys Acta Gene Regul Mech, 2019, 1862(8):834-845 Int Immunopharmacol, 2019, 69:213-216 Nat Commun, 2018, 9(1):2494
S8740	A-485 A-485是一种有效的、选择性的、具有类药性的p300/CBP催化抑制剂，对p300 HAT的IC50值为0.06 μM。相较于BET溴区蛋白和其他大于150种的非表观遗传学靶点，它对p300/CBP更具有选择性。
S6655^New	WM-8014 WM-8014是组蛋白乙酰基转移酶KAT6A的抑制剂，IC50为8 nM。
S8776	WM-1119 WM-1119是一种有效的、选择性赖氨酸乙酰转移酶KAT6A抑制剂，IC50为0.25 μM。WM-1119对KAT6A的活性分别是对KAT5或KAT7的100倍和250倍。
S7582	Anacardic Acid Anacardic Acid是一个有效的p300及p300/CBP相关因子 histone acetyltranferases的抑制剂，也具有抗细菌和抗微生物活性，抑制前列腺素合成，并抑制酪氨酸酶和脂肪氧合酶。	Pigment Cell Melanoma Res, 2019, 10.1111/pcmr.12849 Vet Res, 2019, 50(1):3 Int J Oncol, 2018, 53(4):1469-1480	Western blot analysis of α-SMA expression in whole-lung lysates. Data are expressed as means ± SEM, *P < 0.05 versus vehicle and #P < 0.05 versus PQ (n = 4-6).
S7641	Remodelin Remodelin是一种有效的acetyl-transferase NAT10抑制剂。	Am J Transl Res, 2018, 10(1):256-264 Int J Mol Sci, 2017, 18(9) Am J Transl Res, 2016, 8(10):4215-4223
S9432	Ginkgolic Acid Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).
S7476	MG149 MG149 是强效的histone acetyltransferase抑制剂，其作用于Tip60和MOF的IC50分别为74 μM 和 47 μM。	Nucleic Acids Res, 2019, 10.1093/nar/gkz1136 Plant Growth Regulation, 2018, 10.1007/s10725-018-0460-y J Biol Chem, 2016, 291(35):18190-8

产品目录	产品描述	文献引用	实验数据
S7152	C646 C646是一种histone acetyltransferase抑制剂，抑制p300，无细胞试验中K_i为400 nM，相比于其它乙酰转移酶，优先作用于p300。	Cell Metab,2019, 29(4):886-900 Immunity,2019, 51(6):997-1011 Mol Cell,2019, 74(6):1250-1263	Phosphorylation of STAT6 in butyrate-treated M2-BMDMs. Western blotting was performed with anti-phospho-STAT6, STAT6, and β-actin. Data are representative of three independent experiments. M2:M2 macrophage; But:butyrate.
S1848	Curcumin Curcumin 是流行的印度香料姜黄的主要姜黄色素，属于姜科（Zingiberaceae）。它是p300 histone acetylatransferase（IC50~25 μM）和Histone deacetylase的抑制剂，能够激活Nrf2 pathway并抑制NF-κB的激活。	Biochim Biophys Acta Gene Regul Mech,2019, 1862(8):834-845 Int Immunopharmacol,2019, 69:213-216 Nat Commun,2018, 9(1):2494
S8740	A-485 A-485是一种有效的、选择性的、具有类药性的p300/CBP催化抑制剂，对p300 HAT的IC50值为0.06 μM。相较于BET溴区蛋白和其他大于150种的非表观遗传学靶点，它对p300/CBP更具有选择性。
S6655^New	WM-8014 WM-8014是组蛋白乙酰基转移酶KAT6A的抑制剂，IC50为8 nM。
S8776	WM-1119 WM-1119是一种有效的、选择性赖氨酸乙酰转移酶KAT6A抑制剂，IC50为0.25 μM。WM-1119对KAT6A的活性分别是对KAT5或KAT7的100倍和250倍。
S7582	Anacardic Acid Anacardic Acid是一个有效的p300及p300/CBP相关因子 histone acetyltranferases的抑制剂，也具有抗细菌和抗微生物活性，抑制前列腺素合成，并抑制酪氨酸酶和脂肪氧合酶。	Pigment Cell Melanoma Res,2019, 10.1111/pcmr.12849 Vet Res,2019, 50(1):3 Int J Oncol,2018, 53(4):1469-1480	Western blot analysis of α-SMA expression in whole-lung lysates. Data are expressed as means ± SEM, *P < 0.05 versus vehicle and #P < 0.05 versus PQ (n = 4-6).
S7641	Remodelin Remodelin是一种有效的acetyl-transferase NAT10抑制剂。	Am J Transl Res,2018, 10(1):256-264 Int J Mol Sci,2017, 18(9) Am J Transl Res,2016, 8(10):4215-4223
S9432	Ginkgolic Acid Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).
S7476	MG149 MG149 是强效的histone acetyltransferase抑制剂，其作用于Tip60和MOF的IC50分别为74 μM 和 47 μM。	Nucleic Acids Res,2019, 10.1093/nar/gkz1136 Plant Growth Regulation,2018, 10.1007/s10725-018-0460-y J Biol Chem,2016, 291(35):18190-8