Mineralocorticoid Receptor

抑制剂选择性比较

Mineralocorticoid Receptor产品

目录号 产品描述 文献引用 实验数据
E0704New

Esaxerenone (CS-3150)

Esaxerenone (CS-3150)是一种选择性非甾体盐皮质受体(nonsteroidal mineralocorticoid receptor, MR)拮抗剂,与盐皮质受体结合,抑制(3)H-醛固酮与盐皮质受体结合,IC50为9.4 nM。Esaxerenone (CS-3150)增加蛋白尿恢复到正常水平的可能性,并减少蛋白尿进展到更高水平。

S1707

Eplerenone (CGP 30083)

Eplerenone (CGP 30083, SC-66110) 是一类mineralocorticoid receptor 拮抗剂,阻断了醛固酮的作用,用于控制高血压。

S5273

Canrenone

Canrenone (Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone), a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nonselective aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.

S9702

Finerenone

Finerenone (FIN, BAY 94-8862) 是一种高度选择性的、口服活性的 mineralocorticoid receptor (MR) 的非甾体拮抗剂,IC50值为18 nM。Finerenone 具有研究诸如2型糖尿病和慢性肾脏病等心肾疾病的潜力。

目录号 产品描述 文献引用 实验数据
E0704New

Esaxerenone (CS-3150)

Esaxerenone (CS-3150)是一种选择性非甾体盐皮质受体(nonsteroidal mineralocorticoid receptor, MR)拮抗剂,与盐皮质受体结合,抑制(3)H-醛固酮与盐皮质受体结合,IC50为9.4 nM。Esaxerenone (CS-3150)增加蛋白尿恢复到正常水平的可能性,并减少蛋白尿进展到更高水平。

目录号 产品描述 文献引用 实验数据
S1707

Eplerenone (CGP 30083)

Eplerenone (CGP 30083, SC-66110) 是一类mineralocorticoid receptor 拮抗剂,阻断了醛固酮的作用,用于控制高血压。

S5273

Canrenone

Canrenone (Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone), a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nonselective aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.

S9702

Finerenone

Finerenone (FIN, BAY 94-8862) 是一种高度选择性的、口服活性的 mineralocorticoid receptor (MR) 的非甾体拮抗剂,IC50值为18 nM。Finerenone 具有研究诸如2型糖尿病和慢性肾脏病等心肾疾病的潜力。