Cyclosporin A

目录号:S2286 别名: Cyclosporine A

Cyclosporin A  Chemical Structure

Molecular Weight(MW): 1202.61

Cyclosporin A是一种免疫抑制剂,与亲环素结合,随后抑制calcineurin,无细胞试验中IC50为7 nM,广泛用于预防器官移植反应中的排斥反应。

规格 价格 库存 购买数量  
In DMSO RMB 1073.15 现货
RMB 786.07 现货
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客户使用Selleck该产品发表文献17篇:

客户使用该产品的3个实验数据:

  • Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • Immunophilins participate in SOCE activation by CN-dependent but also CN-independent signaling pathways. Fura-2 loaded platelets were suspended in HBS, platelets are incubated for 5 min with cyclosporin A (CsA, 50 µM). Once incubation time was over, platelets were stimulated with TG (200 nM) in a calcium free-HBS (EGTA 100 μM was added as indicated the by arrowhead) and 4 min later CaCl2 (300 µM) was added to visualized calcium entry. Changes in fura-2 fluorescence were monitored using the 340/380nm ratio and calibrated in terms of [Ca2+]c . Traces are representative of four to six independent experiments. *,**, *** represents p < 0.05, p < 0.01 and p <0.001, respect control platelets.

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.

    Pharm Res, 2016, 33(2):395-403. Cyclosporin A purchased from Selleck.

产品安全说明书

Immunology & Inflammation related抑制剂选择性比较

生物活性

产品描述 Cyclosporin A是一种免疫抑制剂,与亲环素结合,随后抑制calcineurin,无细胞试验中IC50为7 nM,广泛用于预防器官移植反应中的排斥反应。
靶点
calcineurin [1]
(Cell-free assay)
7 nM
体外研究

在T细胞中,Cyclosporin A与亲环蛋白(免疫亲和素)结合[1],形成亲环蛋白-Cyclosporin A复合体,其结合并抑制钙调磷酸酶。[2]Cyclosporin A 抑制钙调磷酸酶,IC50 是7 nM[3],随后阻断NF-AT核转运。 [4]Cyclosporin A通过抑制MTP(线粒体通透性转换孔)的开放而影响线粒体,IC50 是39 nM。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells MlzRSpVv[3Srb36gZZN{[Xl? NF7SPGVKdmirYnn0bY9vKG:oIHzpeoVzKHO2YXflJHBt[XOvb3TpeY0h[mW{Z3jlbUBqdm[nY4Tpc44hcW5iSHXwS|Ih[2WubIOsJGlEPTB;MT62OUBvVQ>? NUfS[IF7OjJ3OE[xNlQ>
Jurkat cells NFjQNmFHfW6ldHnvckBie3OjeR?= NYLUXnk1UW2vdX7vd5VxeHKnc4PpeoUh[WO2aY\peJkhf2G|IH3lZZN2emWmIHL5JIlvcGmkaYTpc44hd2ZidHjlJGlNNTJicILv[JVkfGmxbjDpckBLfXKtYYSgZ4VtdHNuIFnDOVA:OiCwTR?= Mlj3NVQ3PDN|M{e=
human PBMC M{\BT2Z2dmO2aX;uJIF{e2G7 NVy2bYpXOSCq M4PRNGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gVGJOSyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGGwdHmtR2Q{N0OGMkigZY51cWKxZImtbY5lfWOnZDDJUE0zKHC{b3T1Z5Rqd25idILlZZRm\CCob4KgNUBpeiCkZX\vdoUh[W62aT3DSFMwS0R{ODDhcpRq[m:meTDjbIFtdGWwZ3WgcYVie3W{ZXSgZYZ1\XJiNjDodpMh[nliaX3teY5we3WycILld5Nqd25iYYPzZZktKEWFNUC9N{4yKG6P MmfaNVk6OzN5OUW=
human Jurkat cells NXnNSIRQTnWwY4Tpc44h[XO|YYm= NGns[3kyKGh? NIjOSmVCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJGp2emujdDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGGwdHmtR2Q{N0OGMkigZY51cWKxZImtbY5lfWOnZDDJUE0zKHC{b3T1Z5Rqd25idILlZZRm\CCob4KgNUBpeiCkZX\vdoUh[W62aT3DSFMwS0R{ODDhcpRq[m:meTDjbIFtdGWwZ3WgcYVie3W{ZXSgZYZ1\XJiNjDodpMh[nliaX3teY5we3WycILld5Nqd25iYYPzZZktKEWFNUC9OUBvVQ>? MUSxPVk{Ozd7NR?=
human T-cell NW\oeo1pTnWwY4Tpc44h[XO|YYm= NIX3W2ZKdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gWE1k\WyuIIDyc4R2[3Srb36gc4YhdHmvcHjvb4lv\SCLTD2yMEBKSzVyPUiuNUBvVQ>? MofJO|U{PzN|MR?=
human splenocytes MnnNSpVv[3Srb36gZZN{[Xl? NHrzWJg1KGSjeYO= MknlTY1ufW6xc4XwdJJme3OrdnWgZYN1cX[rdImgbY4hcHWvYX6gd5Bt\W6xY4n0[ZMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBcO0ifdHj5cYllcW6nIHnuZ49zeG:{YYTpc44h[W[2ZYKgOEBl[Xm|IHL5JIFtdG:pZX7pZ{BucXinZDDsfY1xcG:leYTlJJJm[WO2aX;uJIF{e2G7LDDJR|UxRTFyIH7N NXXxNVY2OTl6Mke4N|E>
mouse T cells NXjYSXh5TnWwY4Tpc44h[XO|YYm= NIfpV5U1KGSjeYO= MoLaTY1ufW6xc4XwdJJme3OrdnWgZYN1cX[rdImgbY4hdW:3c3WgWEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT3c{B4[XlibXn4[YQhdHmvcHjvZ5l1\SC{ZXHjeIlwdiCjZoTldkA1KGSjeYOgZpkhVVSWIHHzd4F6NCCrY{WwQVEyKG6P MWWyNlk5PDl6Nx?=
human PBMC Mo[xVJJwdGmoZYLheIlwdiCjc4PhfS=> M3rtRmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFLNR{whUUN3ME2xNkBvVQ>? MXOxOVY4QTNyOR?=
human MDA435/LCC6MDR cells MkXQSpVv[3Srb36gZZN{[Xl? MoPJOUBl[Xm| NEfieFZOd2S3bHH0bY9vKG:oIGCt[5AhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCPRFG0N|UwVEOFNl3EVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPpcocheGGlbHn0ZZhmdCC{ZYPpd5RidmOnIH3lZZN2emWmIHHzJINmdGxic4Xyeol3[WxiYX\0[ZIhPSCmYYnzJIJ6KE2WUzDhd5NigSxiRVO1NF0xNjB|MjFOwG0v NEnYXWkzPTl6NUG5OS=>
HEK293 cells NHj4Ro9HfW6ldHnvckBie3OjeR?= M{XpOmlvcGmkaYTpc44hd2ZiT1HUVFFDOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNicILveIVqdi2vZXTpZZRm\CCyaYTheoF{fGG2aX6geZB1[Wun78{MJGtqRTBwMjFOwG0> MoHFNlI2QDd7OE[=
CK1 cells MnP0SpVv[3Srb36gZZN{[Xl? M2XDVGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhRXi1|MzDpcoZm[3SnZDDpckBEUzFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjC3JIRigXNuIGTDOVA:OC5|IN88US=> MVyxPFIyOjFyMB?=
mouse mammary carcinoma cell line EMT6/AR 1.0 NFXlcFRHfW6ldHnvckBie3OjeR?= MlHrVoV3\XK|YXyg[YZn\WO2IH;uJJRp\SCjY3P1cZVt[XSrb36gc4YhYzOKXT2g[IF2dm:{dXLpZ4lvKGmwIH3veZNmKG2jbX3hdpkh[2G{Y3nuc41iKGOnbHygcIlv\SCHTWS2M2FTKDFwMDygTWM2OD1yLkS0JO69VQ>? MYKxNFA6QDZ5MR?=
KB cell NXLLc4VzTnWwY4Tpc44h[XO|YYm= NILi[GlKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhU0JiY3XscEBtcW6nIHHmeIVzKDd{IHigc4Yh\HK3ZzDlfJBwe3W{ZTygTWM2OD1yLk[g{txO NXHqN3MyOTV2OEG5PVE>
mouse L5178 cells NITNRpVHfW6ldHnvckBie3OjeR?= NV74NIJMOjBibXnudy=> M{njfmlvcGmkaYTpc44hd2ZiaIXtZY4hSUKFQkGtcYVlcWG2ZXSgdohw\GGvaX7lJFEzOyCnZn\seZghcW5ibX;1d4UhVDVzN{igZ4VtdHNiZYjwdoV{e2mwZzDoeY1idiCPRGKxJIFnfGW{IEKwJI1qdnNiYomgSmFEWyCjbnHsfZNqeyxiSVO1NF0xNjZ3IN88US=> M{SzbFIyOzRzN{S1
LLC-PK1 epithelial cells M2nxPWZ2dmO2aX;uJIF{e2G7 M{n3R2lvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4tKG2xdYPlJGwudWS{MXKg[ZhxemW|c3XkJIlvKEyOQz3QT|Eh\XCrdHjlcIlidCClZXzsd{B2e2mwZzDjZYxk\WmwLVHNJJBwdGG{aYPheIlwdiCjc4Phfg+9lCCLQ{WwQVAvPyEQvF2= NEXG[G4yOjZ7OUO4PS=>
human K562/R7 cells NX:0Wm5{TnWwY4Tpc44h[XO|YYm= M3TBbVEh|ryP MVq3NkBp M2DZW3BwfGWwdHnheIlwdiCxZjDkc5hwenWkaXPpck1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLYLld4l{fGGwdDDoeY1idiCNNU[yM3I4KGOnbHzzJIF{e2W|c3XkJIF{KGSxeH;yeYJq[2mwIFnDOVAh[XRiMTD1UUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuO{DPxE1? M{HqTFI2PjN2MESx
A2780/ADR cells MojiSpVv[3Srb36gZZN{[Xl? NXO2UVlHUW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdiCneIDy[ZN{\WRiaX6gRVI4QDBxQVTSJINmdGy|IHL5JINidGOnaX6gRW0h[XO|YYpvwKwhUUN3ME2xMlQyOjV2IN88US=> MWSxO|g6ODB7NB?=
KB/MDR cell MoDlSpVv[3Srb36gZZN{[Xl? Mlf2O|IhcA>? M3LN[mlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBMSi:PRGKgZ4VtdCCuaX7lJIFnfGW{IEeyJIhzKG:oIHTyeYch\Xiyb4P1doUtKEmFNUC9NU42KM7:TR?= NGPtbpcyPTR6MUm5NS=>
guinea pig ventricular myocytes M3rkU2Z2dmO2aX;uJIF{e2G7 MX7Jcohq[mm2aX;uJI9nKExvdInw[UBk[WylaYXtJINp[W6wZXygcYVie3W{ZXSgeZNqdmdid3jvcIUu[2WubDDwZZRkcCClbHHtdEBqdiCpdXnu[YEheGmpII\lcpRzcWO3bHHyJI16d2O7dHXzMEBKSzVyPUKg{txO NXHSUoF7OjJ5NkGwNFA>
human MDA435/LCC6MDR cells MoPHR5l1d3SxeHnjxsBie3OjeR?= MoDiO|Jp MljLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCPDN3L1zDR|ZOTFJiY3XscJMh\XiycnXzd4lv\yCPRGKgZYZ1\XJiN{KgbJJ{97zOIFnDOVA:Oi56IN88US=> NVnVUYRJOjJ|MkC0NFI>
human Caco2 cells MUnGeY5kfGmxbjDhd5NigQ>? MnHYcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gR4FkdzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIRq\2:6aX6g[YZndHW6LDDJR|UxRTJwOTFOwG0> NH7ZcZIzOzN6MkS1PC=>
leukemia CEM cells MorwSpVv[3Srb36gZZN{[Xl? MkDCTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIF3EVlEhWC2JbInjc5Bzd3SnaX6gRWJEKFS{YX7zdI9zfGW{IIXzbY5oKGyndXvlcYliKEOHTTDj[YxteyxiSVO1NF0{NjRizszN NGnFeVEyOjN4MUO4Oy=>
human HeLa cells MVrGeY5kfGmxbjDhd5NigQ>? MXzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIVHYuOThiaX7m[YN1\WRiaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDdiZHH5d-+9lCCWQ{WwQVQvPiEQvF2= NVLMcJB7OTh{MUKxNFA>
human 2008 cells NGj6fHNHfW6ldHnvckBie3OjeR?= NGTBcGhKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEGgbY4hcHWvYX6gNlAxQCClZXzsd{whUUN3ME20Mlc5KM7:TR?= M3rVVlE5PzB5OEi0
human HuH7 cells M4j6bGN6fG:2b4jpZ:Kh[XO|YYm= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeWg4KGOnbHzzJIF{e2W|c3XkJIF{KHKnbHXhd4Uhd2ZibHHjeIF1\SCmZXj5[JJw\2WwYYPlMEBKSzVyPUWuPFEh|ryP NIXU[oMzODl2M{O5NC=>
human Huh5-2 cells M13oRmN6fG:2b4jpZ:Kh[XO|YYm= MoPMN{Bl[Xm| MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYg2NTJiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUAtKEOFNUC9OkDPxE1? MU[xPFYzPTd4Nh?=
human HuH6 cells M1K4TGN6fG:2b4jpZ:Kh[XO|YYm= M4fZSlMh\GG7cx?= Mm\aR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPiClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBESzVyPUeg{txO MWSxPFYzPTd4Nh?=
human Huh-9-13 cells NELMNoNEgXSxdH;4bYPDqGG|c3H5 Mo\hN{Bl[Xm| MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYguQS1zMzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F697zOIFPDOVA:PyEQvF2= MWexPFYzPTd4Nh?=
african green monkey Vero cells NXm2ZnRWTnWwY4Tpc44h[XO|YYm= M2PaZVI1KGh? MX3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDX[ZN1KE6rbHWgeolzfXNiaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDDSUmEhe3mwdHjld4l{KGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:QCEQvF2= MmH0NVk1PTF{OE[=
human HeLa cells MlLyR5l1d3SxeHnjxsBie3OjeR?= NVTBPGo3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyxiVFO1NF05NjNizszN M{eycFE5OjF{MUCw
human LCC-6 cells MonYR5l1d3SxeHnjxsBie3OjeR?= M2PMTlczKGh? NIXj[FJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNS0NvNjDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;OD6zJO69VQ>? MVuyNlMzODRyMh?=
MDCK cells M1[xUGN6fG:2b4jpZ:Kh[XO|YYm= MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEONIHPlcIx{NCCWQ{WwQVkvQSEQvF2= MXyxPFIyOjFyMB?=
human Huh-Mono cells MoSyR5l1d3SxeHnjxsBie3OjeR?= NGXocHM{KGSjeYO= NF\sU3VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfWhvTX;uc{Bk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G778{MJGNEPTB;MkSg{txO NIXOXYMyQDZ{NUe2Oi=>
mouse L929 cells NXW5fFdXS3m2b4TvfIlkyqCjc4PhfS=> NG\oTHI{KGSjeYO= MmrwR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUFkzQSClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRUKGG|c3H5MEBKSzVyPUOwJO69VQ>? NX3mbnhROjV7OEWxPVU>
rat H42E cells MYjDfZRwfG:6aXRCpIF{e2G7 NGD6SolEgXSxdH;4bYNqfHliYXfhbY5{fCC{YYSgTFQzTSClZXzsd{Bie3Onc4Pl[EBieyCrboTyZYNmdGy3bHHyJGFVWCCuZY\lcEwhXEN3ME20NkDPxE1? NVv5cmU4OTl3MEKwOVg>

... Click to View More Cell Line Experimental Data

体内研究 Cyclosporin A是一种免疫抑制剂,小鼠,大鼠,和荷兰猪经非肠道给药或者口服给药都有效[6],临床上用于器官移植中预防免疫排斥。[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
- 合并

磷酸酶试验:

纯化的牛脑钙调磷酸酶和钙调蛋白是购买的。含纯化酶的反应混合物包含100 nM 钙调磷酸酶,100 nM 钙调蛋白,以及5 μM 32P-标记磷酸化多肽,60 μl (总体积) 试验缓冲液包含20 mM Tris (pH 8),100 mM NaCI,6 mM MgCl2,0.5 mM 二硫苏糖醇, 每毫升0.1毫克牛血清白蛋白,以及0.1 mM CaCl2或5 mM EGTA。含细胞裂解物的反应混合物包含20 μl of未稀释裂解物, 5 μM 32P-标记的磷酸肽,和40 μl 试验缓冲液。反应混合物包含50 μM 多肽412或413和/或 500 nM冈田酸,一种磷酸酶1和2A的特异性抑制剂; 500 nM 冈田酸足以抑制Ca2+-不依赖性磷酸酶,而更高浓度时也会部分抑制Ca2+-依赖性的活性。30°C下培育15分钟,加入0.5 ml包含5% 三氯乙酸的100 mM 磷酸钾缓冲液(pH 7.0)终止反应。Dowex阳离子交换色谱分离无机磷酸盐,用闪烁计数测定数量。
细胞实验:[3]
- 合并
  • Cell lines: Jurkat细胞(无性繁殖J77)
  • Concentrations: ~100 nM
  • Incubation Time: 1小时
  • Method: 免疫抑制剂以细胞治疗浓度的1000倍溶于乙醇。细胞(106)悬浮于微量离心管1ml完全培养基中;1 μl乙醇或者Cyclosporin A乙醇溶液加入反应液中,细胞在37°C下培育1小时。细胞在冰浴下用1ml PBS洗两次,在50μl低渗缓冲液中裂解,缓冲液每毫升包含50 mM Tris (pH 7.5); 0.1 mM EGTA; 1 mM EDTA; 0.5 mM二硫苏糖醇; 以及50 微克苯甲基磺酰氯,50 微克胰蛋白酶抑制剂,5微克亮抑酶肽,和5 微克抑肽酶。裂解液用液氮冷冻,再在30°C下融化,循环3次,随后在 4°C下以12,000×g离心10分钟。
    (Only for Reference)
动物实验:[6]
- 合并
  • Animal Models: 大鼠
  • Formulation: 0.5% 黄芪胶溶液
  • Dosages: 45毫克/千克
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL warmed (83.15 mM)
Ethanol 100 mg/mL warmed (83.15 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 1202.61
化学式

C62H111N11O12

CAS号 59865-13-3
储存条件 粉状
溶于溶剂
别名 Cyclosporine A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04023760 Recruiting Drug: Apixaban Pharmacokinetics|Kidney Transplant|Lung Transplant University of Saskatchewan|Saskatchewan Health Research Foundation|Lung Association of Saskatchewan June 26 2019 Phase 4
NCT03865888 Completed Drug: Cyclosporins|Drug: Tacrolimus Dry Eye|Sjogren Syndrome Pavly Moawd|Cairo University October 30 2018 Phase 3
NCT01762657 Withdrawn Drug: Oral Cyclosporine and Oral Lansoprazole|Drug: Placebos Type 1 Diabetes Perle Bioscience Inc. September 2014 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What is the difference between S2286 (cyclosporin A) and S1514 (cyclosporin)?

  • 回答:

    Cyclosporine is a mixture of Cyclosporine A, derivatives of Cyclosporine A, salts of Cyclosporine A. Cyclosporine A is an especially useful Cyclosporine component.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID