Obeticholic Acid

For research use only. Not for use in humans.

目录号:S7660 别名: INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid 中文名称:奥贝胆酸

Obeticholic Acid Chemical Structure

CAS No. 459789-99-2

Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid)是一种有效的选择性farnesoid X receptor (FXR)兴奋剂,EC50为99 nM。Obeticholic Acid 可抑制自噬。Phase 3。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1203.93 现货
RMB 809.97 现货
RMB 2851.57 现货
RMB 8001.23 现货
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客户使用Selleck生产的Obeticholic Acid发表文献13篇:

客户使用该产品的3个实验数据:

  • (c) Functional bile canaliculi or lack thereof in PHHs within MPTCs (12 d of drug treatment) as visualized by transport of fluorescent (green) dye into the canaliculi between PHHs. DMSO-treated MPCC control image is shown to the far right. (d) Neutral lipid (Nile red, green) staining of PHHs within MPTCs (12 d of drug treatment). DMSO-treated MPCC control image is shown to the far right. (e) NR1I2 (PXR) gene expression in drug-treated MPTCs relative to DMSOtreated MPTC controls (12 d of treatment). (f) ABCC2 (MRP2) gene expression in drug-treated MPTCs relative to DMSO-treated MPTC controls (12 d of treatment). (g) IL-6 levels in drug-treated MPTC supernatants (6 d of treatment). In all panels, statistical significance is displayed relative to DMSO-treated MPTCs. *p r 0.05, **p r 0.01, ***p r 0.001, and ****p r 0.0001. Scale bars on images represent 80 mm.

    Integr Biol (Camb), 2017, 9(8):662-677. Obeticholic Acid purchased from Selleck.

  • HuCCT1 cells were treated with OCA (1 μM) and control solvent in the presence and absence of IL-6 (20 ng/mL). EMT-related proteins were examined by western blotting. β-actin was used as a control.

    Cell Physiol Biochem, 2018, 48(1):158-172. Obeticholic Acid purchased from Selleck.

  • (D) Expression of hepatic FXR target genes, n = 3. Data are expressed as mean ± SD, ###P < 0.001 versus group 1, *P < 0.05, **P < 0.01, and ***P b 0.001 versus group 2, sP < 0.05, ssP < 0.01, and sssP < 0.001 versus group 3

    Toxicol Appl Pharmacol, 2017, 315:23-34. Obeticholic Acid purchased from Selleck.

质量管理及产品安全说明书

FXR抑制剂选择性比较

生物活性

产品描述 Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid)是一种有效的选择性farnesoid X receptor (FXR)兴奋剂,EC50为99 nM。Obeticholic Acid 可抑制自噬。Phase 3。
靶点
FXR [1]
99 nM(EC50)
体外研究

在HuH7细胞中,Obeticholic Acid是一种有效的FXR激动剂,EC50 为85 nM。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells M2DNcGZ2dmO2aX;uJIF{e2G7 M4nPT|EhcHJ? NWHKcIt6SWexbnnzeEBi[3Srdnn0fUBifCC{ZXPvcYJqdmGwdDDoeY1idiCJU2SteIFo\2WmIF\YVkBtcWejbnSgZolv\GmwZzDkc41icW5iKEG5N{B1dyB2N{KgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIlvfGW{YXP0bY9vKHerdHigZolwfGmwIHzhZoVtdGWmIGPSR{0yKGGodHXyJFEhcHJiYomgTHRTTiCjc4PhfUwhTUN3MDC9JFAvODFizszNMi=> M4foNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS4PFA3Lz5{OUG0PFgxPjxxYU6=
HEK293T NH71bJFHfW6ldHnvckBie3OjeR?= MWqyOEBpenN? MXLB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIF\YVkBmgHC{ZYPz[YQhcW5iSFXLNlk{XCClZXzsd{Bie3Onc4Pl[EBieyCEU1XQJJBzd22xdHXyJIRzcX[nbjDj[YxtfWyjcjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IECuNFQzKM7:TT6= NV\YTZhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxOFg5ODZpPkK5NVQ5QDB4PD;hQi=>
COS1 NFLXXXBHfW6ldHnvckBie3OjeR?= NU\ObFdHSWexbnnzeEBi[3Srdnn0fUBifCCIWGKg[ZhxemW|c3XkJIlvKEORU{GgZ4VtdHNiYomgZ4VtdC2kYYPl[EBjcW:udX3pcoV{[2WwY3WgZZN{[XluIFXDOVAhRSByLkC5PUDPxE1w M1HlXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEG0PFcxLz5{MECxOFg4ODxxYU6=
HeLa M1\temZ2dmO2aX;uJIF{e2G7 NIfIc2gzPCCqcoO= M4Tyd2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6g[pVtdCCuZX7neIghTliUIHX4dJJme3OnZDDpckBJ\UyjIHPlcIx{KGOxdILhcpNn\WO2ZXSge4l1cCCyU1e1MYh2dWGwIGLYVkBi\nSncjCyOEBpenNiYomgSJVidC2JbH:gcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5zNjFOwG0v NYjE[nlKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOjdpPkK1PVM1OjJ5PD;hQi=>
HeLa NEL2colHfW6ldHnvckBie3OjeR?= MmHHRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDGXHIh\XiycnXzd4VlKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVk\XC2b4KgZYN1cX[jdHnvckBjgSCEU1XQJJBzd22xdHXyMYRzcX[nbjDmbZJm\my7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvOTZizszNMi=> NIXLNIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK1OVA{QSd-MkWyOVUxOzl:L3G+
insect cells NVraVIVQTnWwY4Tpc44h[XO|YYm= MkXrNUBpeg>? MUfB[49vcXO2IHHjeIl3cXS7IHH0JJJm[2:vYnnuZY51KGi3bXHuJGdUXC22YXfn[YQhTliUIFzCSEApOTl|IITvJFQ4OiC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{NWmwZnXjeIVlKGmwc3XjeEBk\WyuczDhd5Nme3OnZDDhd{Bz\WO{dXn0cYVvfCCxZjDibY91cW67bHH0[YQhW1KFMTDw[ZB1cWSnIH3lZZN2emWmIHHmeIVzKDFiaIKgZpkhSWyyaHHzZ5Jm\W5iYYPzZZktKEWFNUCgQUAxNjF6IN88UU4> NHToOms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK1PVc1Oid-MkmyOVk4PDJ:L3G+
COS1 MXrGeY5kfGmxbjDhd5NigQ>? NGfHOY42KGi{cx?= M{THT2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gSnhTKGW6cILld5Nm\CCrbjDDU3MyKGOnbHzzJIFnfGW{IEWgbJJ{KGK7IFPSSU1lemm4ZX6gcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5|NkGg{txONg>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ6NU[wN{c,OTd4OEW2NFM9N2F-
CHO MofnSpVv[3Srb36gZZN{[Xl? NYnJfZNsPSCqcoO= MlzjRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDUS3I2KGW6cILld5Nm\CCrbjDDTG8h[2WubIOgZYZ1\XJiNTDodpMh[nliQ2LFMYRzcX[nbjDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjd3NTFOwG0v Moq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OEW2NFMoRjF5Nki1OlA{RC:jPh?=
HEK293 NGTJV2JHfW6ldHnvckBie3OjeR?= MljlNUBpeg>? NFLxdVVC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRIWjViZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IHPBUXAhdGW4ZXygZYZ1\XJiMTDodkBjgSCWUj3GVmVVKGG|c3H5MEBGSzVyIE2gNE45PCEQvF2u MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ3OUe0Nkc,Ojl{NUm3OFI9N2F-
NCI-H716 M1zBdGZ2dmO2aX;uJIF{e2G7 MXLB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGTHVlUhemWlZYD0c5Ih\XiycnXzd4VlKGmwIF7DTU1JPzF4IHPlcIx{KGG|c3Xzd4VlKGG|IHnueJJi[2WubIXsZZIh[0GPUDDs[ZZmdCCkeTDUVk1HWkWWIHHzd4F6NCCHQ{WwJF0hOjBizszNMi=> NILOUng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1PVU5OCd-MkG0OVk2QDB:L3G+
HepG2 NV3qdGhkTnWwY4Tpc44h[XO|YYm= M13WU|IxKHWP NVnVWms1UW6mdXP0bY9vKG:oIF\YVk1u\WSrYYTl[EBUUFBibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFIxKHWPIHL5JHJVNVCFUh?= NF\vWXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1PVU5OCd-MkG0OVk2QDB:L3G+
HepG2 NGize3hHfW6ldHnvckBie3OjeR?= Mle3NUB2VQ>? NX:zc3o2UW6mdXP0bY9vKG:oIF\YVk1u\WSrYYTl[EBUUFBibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFEhfU1iYomgVnQuWEOU NU\1VHRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVk2QDBpPkKxOFU6PThyPD;hQi=>
HepG2 MVzGeY5kfGmxbjDhd5NigQ>? M4HwW|IxKHWP M3n1PGlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSgRnNGWCCvUl7BJIV5eHKnc4Ppc44hcW5iaIXtZY4hUGWyR{KgZ4VtdHNiYYSgNlAhfU1iYomgVnQuWEOU M3fSe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 MVPGeY5kfGmxbjDhd5NigQ>? Mki2NlAhfU1? M4fmSWlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSgU5N1[mW2YTDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOjBidV2gZpkhWlRvUFPS MlnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 M4TqbWZ2dmO2aX;uJIF{e2G7 NVLlVWdbOSC3TR?= M1v5T2lv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSg[I94di2{ZXf1cIF1cW:wIH;mJGN6eDeDMTDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOSC3TTDifUBTXC2SQ2K= MlrqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 M1nT[mZ2dmO2aX;uJIF{e2G7 MnHlNlAhfU1? M1ewPWlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSg[I94di2{ZXf1cIF1cW:wIH;mJGN6eDeDMTDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOjBidV2gZpkhWlRvUFPS NUPXcI13RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVk2QDBpPkKxOFU6PThyPD;hQi=>
HepG2 M1LURmZ2dmO2aX;uJIF{e2G7 NVu2e4F3OjBidV2= MnPURYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDGXHIh\XiycnXzd4VlKGmwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KHKnbnnscIEhdHWlaX\ldoF{\SCjY4Tpeol1gSCjdDCyNEB2VSCkeTDseYNq\mW{YYPlJIJie2WmIITyZY5{[WO2aY\heIlwdiCjc4PhfS=> NHPXd289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1PVU5OCd-MkG0OVk2QDB:L3G+
HepG2 MnLVSpVv[3Srb36gZZN{[Xl? NWrWSpVjOSC3TR?= M1XHSmlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSgRnNGWCCvUl7BJIV5eHKnc4Ppc44hcW5iaIXtZY4hUGWyR{KgZ4VtdHNiYYSgNUB2VSCkeTDSWE1RS1J? M{XaeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 NHLYdmNHfW6ldHnvckBie3OjeR?= M1T0U|EhfU1? NHuwSFNKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJG9{fGKndHGgcXJPSSCneIDy[ZN{cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDFidV2gZpkhWlRvUFPS MoraQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 M{XaNmZ2dmO2aX;uJIF{e2G7 MXGxNEB2VQ>? NEDZSXBVemGwc3HjeIl3[XSrb36gc4YhcHWvYX6gSnhTKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDFyIIXNJIJ6KGKndHGt[4Ft[WO2b4Pp[IF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
HepG2 M{DOSWZ2dmO2aX;uJIF{e2G7 NIfsc3gyOCC3TR?= MoS3NVghcHK| NVHBT2c6SWexbnnzeEBi[3Srdnn0fUBifCCIWGKgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKE:VVD3hcJBp[SCvUl7BJIV5eHKnc4Ppc44h[XRiMUCgeW0h[W[2ZYKgNVghcHK|IHL5JHJVNVCFUjDhcoFtgXOrcx?= MlfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|OEezNlUoRjJ2M{i3N|I2RC:jPh?=
GLUTag NFrScXZHfW6ldHnvckBie3OjeR?= NEC2ZYVC\2:waYP0JIFkfGm4aYT5JIF1KEeSLVLBVlEhcW5ibX;1d4UhT0yXVHHnJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgZ2FOWCCuZY\lcC=> MkXLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|OEezNlUoRjJ2M{i3N|I2RC:jPh?=
HepG2 Mn7oSpVv[3Srb36gZZN{[Xl? MVmxNEB2VQ>? NFLTbG8yQCCqcoO= NUX4S3lNSWexbnnzeEBi[3Srdnn0fUBifCCIWGKgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKFOKUDDtVm5CKGW6cILld5Nqd25iYYSgNVAhfU1iYX\0[ZIhOThiaILzJIJ6KFKWLWDDVkBidmGueYPpdy=> M4mwZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{i3N|I2Lz5{NEO4O|MzPTxxYU6=
HepG2 M1nwe2Z2dmO2aX;uJIF{e2G7 MoPLNVAhfU1? M2TqNFE5KGi{cx?= NWfQOIJ4SWexbnnzeEBi[3Srdnn0fUBifCCIWGKgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKEKHU2CgcXJPSSCneIDy[ZN{cW:wIHH0JFExKHWPIHHmeIVzKDF6IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZM> NILTe409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO4O|MzPSd-MkSzPFc{OjV:L3G+
GLUTag MVTGeY5kfGmxbjDhd5NigQ>? NVPB[m1pSWexbnnzeEBi[3Srdnn0fUBifCCJUD3CRXIyKGmwIH3veZNmKEeOVWTh[{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCJTGCtNUBz\WynYYPl MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
XBP1s; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 6-ECDCA (0-10 μM) or DMSO vehicle for 4 hours. Representative western blot of XBP1s is shown with GAPDH used as a loading control.

p-IRE1α; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 2.5 μM 6-ECDCA or DMSO for 2 hours. Western blotting was performed for phosphorylated-IRE1α (p-IRE1α). Cellular p-IRE1α expression is increased in Huh7-Ntcp cells in response to FXR-agonist treatment.

29377207
体内研究 在大鼠胆汁郁积模型中,Obeticholic Acid促进胆汁流动,并保护肝细胞免受LCA引起的急性坏死。[1] 在WD喂养的DBA 小鼠体内,Obeticholic Acid (p.o.)改善蛋白尿和肾脏结构的改变,并调节肾脏炎症和氧化应激。[2]在硫代乙酰胺(TAA)中毒的和胆小管结扎的(BDL)大鼠体内,Obeticholic Acid (30 mg/kg p.o.) 通过降低总IHVR,恢复FXR下游信号通路,并降低门静脉压力,而不产生有害的全身性低血压。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[1]
- 合并
  • Animal Models: 大鼠胆汁郁积模型
  • Dosages: 生理盐水
  • Administration: 使用 PE-50 聚乙烯管在右颈动脉进行注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 84 mg/mL (199.7 mM)
Water Insoluble
Ethanol ''84 mg/mL warmed

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 420.63
化学式

C26H44O4

CAS号 459789-99-2
储存条件 粉状
溶于溶剂
别名 INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02633956 Completed Drug: Obeticholic Acid|Drug: Atorvastatin|Drug: Placebo Nonalcoholic Steatohepatitis Intercept Pharmaceuticals December 4 2015 Phase 2
NCT02548351 Active not recruiting Drug: Obeticholic Acid|Drug: Placebo Non Alcoholic Steatohepatitis (NASH) Intercept Pharmaceuticals September 22 2015 Phase 3

技术支持

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What formulation can we use to dissolve Obeticholic Acid (Catalog No.S7660) for mice in vivo study?

  • 回答:

    You can use the vehicle of: 1% wt/vol methyl-cellulose as indicated in this paper, http://www.sciencedirect.com/science/article/pii/S0925443911000883 "daily oral gavage with 5 mg/kg/day INT-747 (6-ethyl-chenodeoxycholic acid, Obeticholic acid, Intercept Pharmaceuticals Inc, New York, NY) or vehicle (1% wt/vol methyl-cellulose) from 3 days prior to induction of colitis"

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID