Salubrinal

Salubrinal是一种选择性eIF2α去磷酸化抑制剂,可以抑制ER应激介导的细胞凋亡,无细胞试验中EC50约为15 μM。

Salubrinal Chemical Structure

Salubrinal Chemical Structure

CAS: 405060-95-9

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 2297.41 现货
5mg RMB 1214.29 现货
25mg RMB 3660.93 现货
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客户使用Selleck的Salubrinal发表文献36

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批次: 纯度: 99.94%
99.33

Salubrinal相关产品

PERK抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
BV-173 Growth inhibition assay Inhibition of human BV-173 cell growth in a cell viability assay, IC50 = 11.5021 μM. SANGER
TE-12 Growth inhibition assay Inhibition of human TE-12 cell growth in a cell viability assay, IC50 = 11.3357 μM. SANGER
MC116 Growth inhibition assay Inhibition of human MC116 cell growth in a cell viability assay, IC50 = 11.2073 μM. SANGER
LXF-289 Growth inhibition assay Inhibition of human LXF-289 cell growth in a cell viability assay, IC50 = 11.1547 μM. SANGER
HC-1 Growth inhibition assay Inhibition of human HC-1 cell growth in a cell viability assay, IC50 = 11.1547 μM. SANGER
K-562 Growth inhibition assay Inhibition of human K-562 cell growth in a cell viability assay, IC50 = 11.0191 μM. SANGER
8-MG-BA Growth inhibition assay Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50 = 10.9999 μM. SANGER
HEL Growth inhibition assay Inhibition of human HEL cell growth in a cell viability assay, IC50 = 10.6252 μM. SANGER
NKM-1 Growth inhibition assay Inhibition of human NKM-1 cell growth in a cell viability assay, IC50 = 10.6196 μM. SANGER
MONO-MAC-6 Growth inhibition assay Inhibition of human MONO-MAC-6 cell growth in a cell viability assay, IC50 = 10.5482 μM. SANGER
DOHH-2 Growth inhibition assay Inhibition of human DOHH-2 cell growth in a cell viability assay, IC50 = 10.2262 μM. SANGER
Ramos-2G6-4C10 Growth inhibition assay Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay, IC50 = 9.90315 μM. SANGER
BL-41 Growth inhibition assay Inhibition of human BL-41 cell growth in a cell viability assay, IC50 = 9.78049 μM. SANGER
EW-1 Growth inhibition assay Inhibition of human EW-1 cell growth in a cell viability assay, IC50 = 9.7124 μM. SANGER
EB-3 Growth inhibition assay Inhibition of human EB-3 cell growth in a cell viability assay, IC50 = 9.62572 μM. SANGER
HAL-01 Growth inhibition assay Inhibition of human HAL-01 cell growth in a cell viability assay, IC50 = 9.31505 μM. SANGER
HT Growth inhibition assay Inhibition of human HT cell growth in a cell viability assay, IC50 = 8.94185 μM. SANGER
ES8 Growth inhibition assay Inhibition of human ES8 cell growth in a cell viability assay, IC50 = 8.64339 μM. SANGER
ST486 Growth inhibition assay Inhibition of human ST486 cell growth in a cell viability assay, IC50 = 8.5368 μM. SANGER
A3-KAW Growth inhibition assay Inhibition of human A3-KAW cell growth in a cell viability assay, IC50 = 8.43289 μM. SANGER
BE-13 Growth inhibition assay Inhibition of human BE-13 cell growth in a cell viability assay, IC50 = 8.2684 μM. SANGER
LB2518-MEL Growth inhibition assay Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50 = 7.97326 μM. SANGER
MRK-nu-1 Growth inhibition assay Inhibition of human MRK-nu-1 cell growth in a cell viability assay, IC50 = 7.75171 μM. SANGER
NCI-H720 Growth inhibition assay Inhibition of human NCI-H720 cell growth in a cell viability assay, IC50 = 7.57268 μM. SANGER
NCI-H510A Growth inhibition assay Inhibition of human NCI-H510A cell growth in a cell viability assay, IC50 = 7.03535 μM. SANGER
MHH-PREB-1 Growth inhibition assay Inhibition of human MHH-PREB-1 cell growth in a cell viability assay, IC50 = 6.78817 μM. SANGER
Daudi Growth inhibition assay Inhibition of human Daudi cell growth in a cell viability assay, IC50 = 6.33699 μM. SANGER
NEC8 Growth inhibition assay Inhibition of human NEC8 cell growth in a cell viability assay, IC50 = 6.05331 μM. SANGER
Becker Growth inhibition assay Inhibition of human Becker cell growth in a cell viability assay, IC50 = 5.79401 μM. SANGER
LB2241-RCC Growth inhibition assay Inhibition of human LB2241-RCC cell growth in a cell viability assay, IC50 = 4.98572 μM. SANGER
ML-2 Growth inhibition assay Inhibition of human ML-2 cell growth in a cell viability assay, IC50 = 4.61833 μM. SANGER
ALL-PO Growth inhibition assay Inhibition of human ALL-PO cell growth in a cell viability assay, IC50 = 4.08655 μM. SANGER
697 Growth inhibition assay Inhibition of human 697 cell growth in a cell viability assay, IC50 = 3.98788 μM. SANGER
LP-1 Growth inhibition assay Inhibition of human LP-1 cell growth in a cell viability assay, IC50 = 3.37112 μM. SANGER
NCCIT Growth inhibition assay Inhibition of human NCCIT cell growth in a cell viability assay, IC50 = 11.6039 μM. SANGER
CESS Growth inhibition assay Inhibition of human CESS cell growth in a cell viability assay, IC50 = 11.6662 μM. SANGER
HUTU-80 Growth inhibition assay Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50 = 11.6704 μM. SANGER
IST-SL2 Growth inhibition assay Inhibition of human IST-SL2 cell growth in a cell viability assay, IC50 = 11.7704 μM. SANGER
ATN-1 Growth inhibition assay Inhibition of human ATN-1 cell growth in a cell viability assay, IC50 = 12.0227 μM. SANGER
HCC1599 Growth inhibition assay Inhibition of human HCC1599 cell growth in a cell viability assay, IC50 = 12.1094 μM. SANGER
NTERA-S-cl-D1 Growth inhibition assay Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay, IC50 = 12.8888 μM. SANGER
EVSA-T Growth inhibition assay Inhibition of human EVSA-T cell growth in a cell viability assay, IC50 = 12.9204 μM. SANGER
NALM-6 Growth inhibition assay Inhibition of human NALM-6 cell growth in a cell viability assay, IC50 = 13.093 μM. SANGER
KMOE-2 Growth inhibition assay Inhibition of human KMOE-2 cell growth in a cell viability assay, IC50 = 13.1092 μM. SANGER
HL-60 Growth inhibition assay Inhibition of human HL-60 cell growth in a cell viability assay, IC50 = 13.3308 μM. SANGER
D-542MG Growth inhibition assay Inhibition of human D-542MG cell growth in a cell viability assay, IC50 = 13.4306 μM. SANGER
L-363 Growth inhibition assay Inhibition of human L-363 cell growth in a cell viability assay, IC50 = 13.5583 μM. SANGER
CMK Growth inhibition assay Inhibition of human CMK cell growth in a cell viability assay, IC50 = 13.7436 μM. SANGER
IMR-5 Growth inhibition assay Inhibition of human IMR-5 cell growth in a cell viability assay, IC50 = 13.7849 μM. SANGER
A101D Growth inhibition assay Inhibition of human A101D cell growth in a cell viability assay, IC50 = 13.8206 μM. SANGER
MOLT-16 Growth inhibition assay Inhibition of human MOLT-16 cell growth in a cell viability assay, IC50 = 13.9665 μM. SANGER
LU-139 Growth inhibition assay Inhibition of human LU-139 cell growth in a cell viability assay, IC50 = 14.0444 μM. SANGER
A4-Fuk Growth inhibition assay Inhibition of human A4-Fuk cell growth in a cell viability assay, IC50 = 14.1299 μM. SANGER
J-RT3-T3-5 Growth inhibition assay Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay, IC50 = 14.6941 μM. SANGER
OVCAR-4 Growth inhibition assay Inhibition of human OVCAR-4 cell growth in a cell viability assay, IC50 = 14.7604 μM. SANGER
BC-3 Growth inhibition assay Inhibition of human BC-3 cell growth in a cell viability assay, IC50 = 14.7982 μM. SANGER
D-336MG Growth inhibition assay Inhibition of human D-336MG cell growth in a cell viability assay, IC50 = 15.1134 μM. SANGER
BC-1 Growth inhibition assay Inhibition of human BC-1 cell growth in a cell viability assay, IC50 = 15.198 μM. SANGER
KE-37 Growth inhibition assay Inhibition of human KE-37 cell growth in a cell viability assay, IC50 = 15.2825 μM. SANGER
LAMA-84 Growth inhibition assay Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50 = 15.7455 μM. SANGER
OCI-AML2 Growth inhibition assay Inhibition of human OCI-AML2 cell growth in a cell viability assay, IC50 = 15.9159 μM. SANGER
L-540 Growth inhibition assay Inhibition of human L-540 cell growth in a cell viability assay, IC50 = 15.9712 μM. SANGER
JiyoyeP-2003 Growth inhibition assay Inhibition of human JiyoyeP-2003 cell growth in a cell viability assay, IC50 = 16.0011 μM. SANGER
MEG-01 Growth inhibition assay Inhibition of human MEG-01 cell growth in a cell viability assay, IC50 = 16.057 μM. SANGER
NOS-1 Growth inhibition assay Inhibition of human NOS-1 cell growth in a cell viability assay, IC50 = 16.0998 μM. SANGER
GI-ME-N Growth inhibition assay Inhibition of human GI-ME-N cell growth in a cell viability assay, IC50 = 17.1098 μM. SANGER
NB1 Growth inhibition assay Inhibition of human NB1 cell growth in a cell viability assay, IC50 = 17.2295 μM. SANGER
KU812 Growth inhibition assay Inhibition of human KU812 cell growth in a cell viability assay, IC50 = 17.2534 μM. SANGER
NCI-H1355 Growth inhibition assay Inhibition of human NCI-H1355 cell growth in a cell viability assay, IC50 = 17.3491 μM. SANGER
JAR Growth inhibition assay Inhibition of human JAR cell growth in a cell viability assay, IC50 = 17.4931 μM. SANGER
RPMI-8226 Growth inhibition assay Inhibition of human RPMI-8226 cell growth in a cell viability assay, IC50 = 18.1636 μM. SANGER
CCRF-CEM Growth inhibition assay Inhibition of human CCRF-CEM cell growth in a cell viability assay, IC50 = 18.6377 μM. SANGER
RS4-11 Growth inhibition assay Inhibition of human RS4-11 cell growth in a cell viability assay, IC50 = 18.9889 μM. SANGER
SIG-M5 Growth inhibition assay Inhibition of human SIG-M5 cell growth in a cell viability assay, IC50 = 19.1579 μM. SANGER
Calu-6 Growth inhibition assay Inhibition of human Calu-6 cell growth in a cell viability assay, IC50 = 19.4402 μM. SANGER
NMC-G1 Growth inhibition assay Inhibition of human NMC-G1 cell growth in a cell viability assay, IC50 = 19.64 μM. SANGER
HD-MY-Z Growth inhibition assay Inhibition of human HD-MY-Z cell growth in a cell viability assay, IC50 = 19.9247 μM. SANGER
KS-1 Growth inhibition assay Inhibition of human KS-1 cell growth in a cell viability assay, IC50 = 19.9385 μM. SANGER
IST-SL1 Growth inhibition assay Inhibition of human IST-SL1 cell growth in a cell viability assay, IC50 = 20.4273 μM. SANGER
EM-2 Growth inhibition assay Inhibition of human EM-2 cell growth in a cell viability assay, IC50 = 20.4831 μM. SANGER
NCI-SNU-16 Growth inhibition assay Inhibition of human NCI-SNU-16 cell growth in a cell viability assay, IC50 = 21.0539 μM. SANGER
CTV-1 Growth inhibition assay Inhibition of human CTV-1 cell growth in a cell viability assay, IC50 = 21.5621 μM. SANGER
CTB-1 Growth inhibition assay Inhibition of human CTB-1 cell growth in a cell viability assay, IC50 = 21.604 μM. SANGER
BL-70 Growth inhibition assay Inhibition of human BL-70 cell growth in a cell viability assay, IC50 = 21.6293 μM. SANGER
ONS-76 Growth inhibition assay Inhibition of human ONS-76 cell growth in a cell viability assay, IC50 = 22.3043 μM. SANGER
MOLT-4 Growth inhibition assay Inhibition of human MOLT-4 cell growth in a cell viability assay, IC50 = 22.3794 μM. SANGER
SCC-3 Growth inhibition assay Inhibition of human SCC-3 cell growth in a cell viability assay, IC50 = 22.5454 μM. SANGER
RCC10RGB Growth inhibition assay Inhibition of human RCC10RGB cell growth in a cell viability assay, IC50 = 22.6146 μM. SANGER
HCC2998 Growth inhibition assay Inhibition of human HCC2998 cell growth in a cell viability assay, IC50 = 23.1268 μM. SANGER
NCI-H82 Growth inhibition assay Inhibition of human NCI-H82 cell growth in a cell viability assay, IC50 = 23.2329 μM. SANGER
MV-4-11 Growth inhibition assay Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50 = 23.3519 μM. SANGER
D-247MG Growth inhibition assay Inhibition of human D-247MG cell growth in a cell viability assay, IC50 = 23.554 μM. SANGER
LB771-HNC Growth inhibition assay Inhibition of human LB771-HNC cell growth in a cell viability assay, IC50 = 23.627 μM. SANGER
COR-L279 Growth inhibition assay Inhibition of human COR-L279 cell growth in a cell viability assay, IC50 = 23.8825 μM. SANGER
NOMO-1 Growth inhibition assay Inhibition of human NOMO-1 cell growth in a cell viability assay, IC50 = 23.8983 μM. SANGER
HCC2218 Growth inhibition assay Inhibition of human HCC2218 cell growth in a cell viability assay, IC50 = 24.5033 μM. SANGER
GT3TKB Growth inhibition assay Inhibition of human GT3TKB cell growth in a cell viability assay, IC50 = 24.545 μM. SANGER
NCI-H1581 Growth inhibition assay Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50 = 24.5661 μM. SANGER
NCI-H69 Growth inhibition assay Inhibition of human NCI-H69 cell growth in a cell viability assay, IC50 = 24.7802 μM. SANGER
OCUB-M Growth inhibition assay Inhibition of human OCUB-M cell growth in a cell viability assay, IC50 = 24.9094 μM. SANGER
DG-75 Growth inhibition assay Inhibition of human DG-75 cell growth in a cell viability assay, IC50 = 25.8203 μM. SANGER
CA46 Growth inhibition assay Inhibition of human CA46 cell growth in a cell viability assay, IC50 = 25.8561 μM. SANGER
TE-9 Growth inhibition assay Inhibition of human TE-9 cell growth in a cell viability assay, IC50 = 26.298 μM. SANGER
MZ2-MEL Growth inhibition assay Inhibition of human MZ2-MEL cell growth in a cell viability assay, IC50 = 26.6189 μM. SANGER
KARPAS-45 Growth inhibition assay Inhibition of human KARPAS-45 cell growth in a cell viability assay, IC50 = 27.3193 μM. SANGER
UACC-257 Growth inhibition assay Inhibition of human UACC-257 cell growth in a cell viability assay, IC50 = 27.5003 μM. SANGER
ES6 Growth inhibition assay Inhibition of human ES6 cell growth in a cell viability assay, IC50 = 28.2266 μM. SANGER
TGW Growth inhibition assay Inhibition of human TGW cell growth in a cell viability assay, IC50 = 28.5191 μM. SANGER
L-428 Growth inhibition assay Inhibition of human L-428 cell growth in a cell viability assay, IC50 = 28.7156 μM. SANGER
COLO-320-HSR Growth inhibition assay Inhibition of human COLO-320-HSR cell growth in a cell viability assay, IC50 = 28.9891 μM. SANGER
TE-10 Growth inhibition assay Inhibition of human TE-10 cell growth in a cell viability assay, IC50 = 29.223 μM. SANGER
COR-L88 Growth inhibition assay Inhibition of human COR-L88 cell growth in a cell viability assay, IC50 = 29.9805 μM. SANGER
LB996-RCC Growth inhibition assay Inhibition of human LB996-RCC cell growth in a cell viability assay, IC50 = 30.0438 μM. SANGER
HCC2157 Growth inhibition assay Inhibition of human HCC2157 cell growth in a cell viability assay, IC50 = 30.1625 μM. SANGER
HT-144 Growth inhibition assay Inhibition of human HT-144 cell growth in a cell viability assay, IC50 = 30.273 μM. SANGER
COLO-684 Growth inhibition assay Inhibition of human COLO-684 cell growth in a cell viability assay, IC50 = 30.4113 μM. SANGER
CP66-MEL Growth inhibition assay Inhibition of human CP66-MEL cell growth in a cell viability assay, IC50 = 30.4775 μM. SANGER
COLO-824 Growth inhibition assay Inhibition of human COLO-824 cell growth in a cell viability assay, IC50 = 30.9352 μM. SANGER
NCI-H209 Growth inhibition assay Inhibition of human NCI-H209 cell growth in a cell viability assay, IC50 = 31.7266 μM. SANGER
RPMI-6666 Growth inhibition assay Inhibition of human RPMI-6666 cell growth in a cell viability assay, IC50 = 32.0896 μM. SANGER
NCI-SNU-5 Growth inhibition assay Inhibition of human NCI-SNU-5 cell growth in a cell viability assay, IC50 = 32.1346 μM. SANGER
NCI-H1963 Growth inhibition assay Inhibition of human NCI-H1963 cell growth in a cell viability assay, IC50 = 32.1673 μM. SANGER
ES1 Growth inhibition assay Inhibition of human ES1 cell growth in a cell viability assay, IC50 = 32.6132 μM. SANGER
SIMA Growth inhibition assay Inhibition of human SIMA cell growth in a cell viability assay, IC50 = 32.64 μM. SANGER
K052 Growth inhibition assay Inhibition of human K052 cell growth in a cell viability assay, IC50 = 32.6965 μM. SANGER
DB Growth inhibition assay Inhibition of human DB cell growth in a cell viability assay, IC50 = 33.1128 μM. SANGER
LAN-6 Growth inhibition assay Inhibition of human LAN-6 cell growth in a cell viability assay, IC50 = 33.1613 μM. SANGER
TE-1 Growth inhibition assay Inhibition of human TE-1 cell growth in a cell viability assay, IC50 = 33.2542 μM. SANGER
PF-382 Growth inhibition assay Inhibition of human PF-382 cell growth in a cell viability assay, IC50 = 34.3366 μM. SANGER
LS-411N Growth inhibition assay Inhibition of human LS-411N cell growth in a cell viability assay, IC50 = 34.6261 μM. SANGER
KNS-81-FD Growth inhibition assay Inhibition of human KNS-81-FD cell growth in a cell viability assay, IC50 = 34.8848 μM. SANGER
DJM-1 Growth inhibition assay Inhibition of human DJM-1 cell growth in a cell viability assay, IC50 = 35.3674 μM. SANGER
MC-CAR Growth inhibition assay Inhibition of human MC-CAR cell growth in a cell viability assay, IC50 = 35.5256 μM. SANGER
GI-1 Growth inhibition assay Inhibition of human GI-1 cell growth in a cell viability assay, IC50 = 35.5327 μM. SANGER
MOLT-13 Growth inhibition assay Inhibition of human MOLT-13 cell growth in a cell viability assay, IC50 = 35.6624 μM. SANGER
KM12 Growth inhibition assay Inhibition of human KM12 cell growth in a cell viability assay, IC50 = 35.7371 μM. SANGER
NCI-H64 Growth inhibition assay Inhibition of human NCI-H64 cell growth in a cell viability assay, IC50 = 35.7738 μM. SANGER
MPP-89 Growth inhibition assay Inhibition of human MPP-89 cell growth in a cell viability assay, IC50 = 36.9055 μM. SANGER
PSN1 Growth inhibition assay Inhibition of human PSN1 cell growth in a cell viability assay, IC50 = 37.1904 μM. SANGER
NCI-H2126 Growth inhibition assay Inhibition of human NCI-H2126 cell growth in a cell viability assay, IC50 = 37.6544 μM. SANGER
EKVX Growth inhibition assay Inhibition of human EKVX cell growth in a cell viability assay, IC50 = 38.3242 μM. SANGER
SHP-77 Growth inhibition assay Inhibition of human SHP-77 cell growth in a cell viability assay, IC50 = 39.3648 μM. SANGER
KMS-12-PE Growth inhibition assay Inhibition of human KMS-12-PE cell growth in a cell viability assay, IC50 = 39.5152 μM. SANGER
RKO Growth inhibition assay Inhibition of human RKO cell growth in a cell viability assay, IC50 = 39.6481 μM. SANGER
SK-LMS-1 Growth inhibition assay Inhibition of human SK-LMS-1 cell growth in a cell viability assay, IC50 = 40.7279 μM. SANGER
DMS-153 Growth inhibition assay Inhibition of human DMS-153 cell growth in a cell viability assay, IC50 = 42.3528 μM. SANGER
GCIY Growth inhibition assay Inhibition of human GCIY cell growth in a cell viability assay, IC50 = 43.1088 μM. SANGER
MFH-ino Growth inhibition assay Inhibition of human MFH-ino cell growth in a cell viability assay, IC50 = 43.6888 μM. SANGER
RXF393 Growth inhibition assay Inhibition of human RXF393 cell growth in a cell viability assay, IC50 = 44.458 μM. SANGER
NB13 Growth inhibition assay Inhibition of human NB13 cell growth in a cell viability assay, IC50 = 44.8691 μM. SANGER
D-392MG Growth inhibition assay Inhibition of human D-392MG cell growth in a cell viability assay, IC50 = 45.4383 μM. SANGER
KNS-42 Growth inhibition assay Inhibition of human KNS-42 cell growth in a cell viability assay, IC50 = 45.5753 μM. SANGER
HOP-62 Growth inhibition assay Inhibition of human HOP-62 cell growth in a cell viability assay, IC50 = 47.6626 μM. SANGER
HCE-T Growth inhibition assay Inhibition of human HCE-T cell growth in a cell viability assay, IC50 = 47.9693 μM. SANGER
MLMA Growth inhibition assay Inhibition of human MLMA cell growth in a cell viability assay, IC50 = 48.8336 μM. SANGER
ECC12 Growth inhibition assay Inhibition of human ECC12 cell growth in a cell viability assay, IC50 = 48.9803 μM. SANGER
no-11 Growth inhibition assay Inhibition of human no-11 cell growth in a cell viability assay, IC50 = 48.9923 μM. SANGER
NCI-H1648 Growth inhibition assay Inhibition of human NCI-H1648 cell growth in a cell viability assay, IC50 = 49.2167 μM. SANGER
点击查看更多细胞系数据

生物活性

产品描述 Salubrinal是一种选择性eIF2α去磷酸化抑制剂,可以抑制ER应激介导的细胞凋亡,无细胞试验中EC50约为15 μM。
靶点
eIF2α [1]
(Cell-free assay)
体外研究(In Vitro)
体外研究活性

Salubrinal是一种选择性细胞复合体抑制剂,抑制真核翻译起始因子2亚基α(eIF2α)去磷酸化。Salubrinal抑制蛋白糖基化抑制剂Tunicamycin(TM)诱导的ER应激介导的细胞凋亡,这种作用具有剂量依赖性,半数有效浓度(EC50)为15 μM。Salubrinal在caspase-7加工过程中,也抑制TM诱导的DNA断裂,ER应激激活caspase-7。然而,Salubrinal不是一般的凋亡抑制剂。Salubrinal作用于PC12细胞,快速且强效诱导eIF2α磷酸化及其下游效应,包括下调cyclin D1和上调GADD34和CHOP,eIF2α磷酸化诱导GADD34和CHOP这两种蛋白质的表达。Salubrinal通过抑制PP1/GADD34复合体,而抑制eIF2α去磷酸化。Salubrinal通过抑制eIF2α去磷酸化,而抑制HSV复制,IC50为3μM。[1]Salubrinal增强非快速眼动(NREM)睡眠。[2]

细胞实验 细胞系 PC12
浓度 0-100 μM
孵育时间 48 小时
方法

PC12细胞按每孔5000个接种在383孔板中,孔中为含3μg/ml TM 的40μL无酚红培养基,诱导ER应激。通过自动化针转移将100 nL DiverSet E (5 mg/mlin DMSO) 或美国国家癌症研究所(NCI) 结构多样性设置和开放性收集 (10 mM,溶于DMSO) (NCI)加入到孔中。48小时后,通过发光ATP实验测定细胞活力。每组实验板上DMSO和zVAD.fmk处理的孔分别作为阴性和阳性对照,缓解ER应激诱导的ATP损耗。

实验图片 检测方法 检测指标 实验图片 PMID
Western blot ATF4 HSF1 / p-HSF1 / ATF3 / c-fos / NFATc1 / RelA GRP78 / p-eIF2α / CHOP 27729194
体内研究(In Vivo)
体内研究活性

Salubrinal处理小鼠角膜感染的模型,抑制HSV复制。与对照组比,Salubrinal局部处理,显著降低感染动物眼拭子中恢复的病毒滴度。[1]Salubrinal脑室内给药处理,显著改变稳态睡眠响应。[3]

动物实验 Animal Models 8周大的雄性CD-1远交系小鼠
Dosages 75μM
Administration 角膜上滴定

化学信息&溶解度

分子量 479.81 分子式

C21H17Cl3N4OS

CAS号 405060-95-9 SDF Download Salubrinal SDF
Smiles C1=CC=C(C=C1)C=CC(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 96 mg/mL ( 200.07 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Ethanol : 2 mg/mL

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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