Proton Pump

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研究领域

抑制剂选择性比较

Proton Pump产品

所有产品 Proton Pump抑制剂(16)

目录号	产品描述	文献引用	实验数据
S1354	Lansoprazole Lansoprazole (A-65006, AG-1749)是一种质子泵抑制剂（PPI）可共价结合壁细胞的 H(+),K(+)-ATPase，防止胃产生胃酸。	Front Microbiol, 2019, 10:2790
S1389	Omeprazole Omeprazole 是一种可阻滞 H(+)-K(+)-ATPase 的质子泵抑制剂，用于治疗消化不良，消化性溃疡，胃食管逆流，咽喉逆流。	Redox Biol, 2020, 32:101464 Int J Oncol, 2019, 54(3):1061-1070
S1413	Bafilomycin A1(Baf-A1) Bafilomycin A1(Baf-A1)是一种液泡H⁺-ATPase抑制剂，IC50为0.44 nM。研究发现 Bafilomycin A1 可以抑制自噬，但是诱导凋亡。	Nat Commun, 2020, 11(1):5731 Sci Adv, 2020, 29;6(18):eaax7881 Autophagy, 2020, 10.1080/15548627.2020.1740529	Mitochondrial depolarization mediated relocation of mitochondrial RC-TPP into lysosomes and the ensuing lysosomal acidity triggered rhodamine fluorescence. RC-TPP-loaded Tom20-GFP+ HeLa cells were treated without or with CCCP (20 μM) in the presence or absence of BFA (200 nM). Colocalization of Tom20-GFP (in green) and mitochondrial RC-TPP (in blue) is shown in cyan. Scale bar: 10 μm.
S1743	NEXIUM (esomeprazole magnesium) Esomeprazole Magnesium 是一种质子泵 proton pump 抑制剂，在胃壁细胞中通过抑制 H(+)/K(+)-ATPase 减少胃酸分泌。
S4075	Zinc Pyrithione Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物，可以通过阻断质子泵破坏膜转运。	Biol Reprod, 2019, 100(2):468-478 Cell Syst, 2017, 4(6-:600-610
S2222	PF-3716556 PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H⁺，K⁺-ATPase活性，抑制胃酸分泌，对Na⁺，K⁺-ATPas没有作用活性，用于治疗胃食管返流疾病。
S4099	Dexlansoprazole Dexlansoprazole (T 168390, TAK 390)是Lansoprazole的右旋对映体，是质子泵抑制剂（PPI），具有双重缓释性能。Dexlansoprazole 作用于胃壁细胞，通过直接抑制 H(+),K(+)-ATPase 质子泵选择性地抑制胃酸分泌。	Front Microbiol, 2019, 10:2790
S4845	Rabeprazole Rabeprazole is an oral inhibitor of proton pump and blocks the production of acid by the stomach.	Front Microbiol, 2019, 10:2790
S5658	Omeprazole Sodium Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.	Adv Ther (Weinh), 2020, 2000034
S5502	Ilaprazole sodium Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.
S3666	Ilaprazole Ilaprazole是新型的质子泵 (proton pump)抑制剂，用于治疗消化不良、消化性溃疡、胃食管返流疾病和十二指肠溃疡。它能抑制H+/K+-ATPase，IC50为6 μM。
S4212	Tenatoprazole Tenatoprazole (TU-199)是proton pump 抑制剂类前药, 抑制质子的运输，IC50为3.2 μM。Tenatoprazole 仅标记胃部 H(+),K(+)-ATPase 的α-亚基，约2.6 nM/mg 结合于 H(+),K(+)-ATPase。
S4665	Rabeprazole sodium Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole)是一种抗溃疡药物，是质子泵的抑制剂。
S4538	Pantoprazole sodium Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。
S2105	Pantoprazole Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。	Front Microbiol, 2019, 10:2790
S5058	Revaprazan Hydrochloride Revaprazan Hydrochloride (YH1885) 是一种新型可逆的proton pump抑制剂，具有长效抑酸活性。Revaprazan Hydrochloride 通过结合泵上K+结合位点来可逆性地抑制 H(+)/K(+)-ATPase。

目录号	产品描述	文献引用	实验数据
S1354	Lansoprazole Lansoprazole (A-65006, AG-1749)是一种质子泵抑制剂（PPI）可共价结合壁细胞的 H(+),K(+)-ATPase，防止胃产生胃酸。	Front Microbiol,2019, 10:2790
S1389	Omeprazole Omeprazole 是一种可阻滞 H(+)-K(+)-ATPase 的质子泵抑制剂，用于治疗消化不良，消化性溃疡，胃食管逆流，咽喉逆流。	Redox Biol,2020, 32:101464 Int J Oncol,2019, 54(3):1061-1070
S1413	Bafilomycin A1(Baf-A1) Bafilomycin A1(Baf-A1)是一种液泡H⁺-ATPase抑制剂，IC50为0.44 nM。研究发现 Bafilomycin A1 可以抑制自噬，但是诱导凋亡。	Nat Commun,2020, 11(1):5731 Sci Adv,2020, 29;6(18):eaax7881 Autophagy,2020, 10.1080/15548627.2020.1740529	Mitochondrial depolarization mediated relocation of mitochondrial RC-TPP into lysosomes and the ensuing lysosomal acidity triggered rhodamine fluorescence. RC-TPP-loaded Tom20-GFP+ HeLa cells were treated without or with CCCP (20 μM) in the presence or absence of BFA (200 nM). Colocalization of Tom20-GFP (in green) and mitochondrial RC-TPP (in blue) is shown in cyan. Scale bar: 10 μm.
S1743	NEXIUM (esomeprazole magnesium) Esomeprazole Magnesium 是一种质子泵 proton pump 抑制剂，在胃壁细胞中通过抑制 H(+)/K(+)-ATPase 减少胃酸分泌。
S4075	Zinc Pyrithione Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物，可以通过阻断质子泵破坏膜转运。	Biol Reprod,2019, 100(2):468-478 Cell Syst,2017, 4(6-:600-610
S2222	PF-3716556 PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H⁺，K⁺-ATPase活性，抑制胃酸分泌，对Na⁺，K⁺-ATPas没有作用活性，用于治疗胃食管返流疾病。
S4099	Dexlansoprazole Dexlansoprazole (T 168390, TAK 390)是Lansoprazole的右旋对映体，是质子泵抑制剂（PPI），具有双重缓释性能。Dexlansoprazole 作用于胃壁细胞，通过直接抑制 H(+),K(+)-ATPase 质子泵选择性地抑制胃酸分泌。	Front Microbiol,2019, 10:2790
S4845	Rabeprazole Rabeprazole is an oral inhibitor of proton pump and blocks the production of acid by the stomach.	Front Microbiol,2019, 10:2790
S5658	Omeprazole Sodium Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.	Adv Ther (Weinh),2020, 2000034
S5502	Ilaprazole sodium Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.
S3666	Ilaprazole Ilaprazole是新型的质子泵 (proton pump)抑制剂，用于治疗消化不良、消化性溃疡、胃食管返流疾病和十二指肠溃疡。它能抑制H+/K+-ATPase，IC50为6 μM。
S4212	Tenatoprazole Tenatoprazole (TU-199)是proton pump 抑制剂类前药, 抑制质子的运输，IC50为3.2 μM。Tenatoprazole 仅标记胃部 H(+),K(+)-ATPase 的α-亚基，约2.6 nM/mg 结合于 H(+),K(+)-ATPase。
S4665	Rabeprazole sodium Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole)是一种抗溃疡药物，是质子泵的抑制剂。
S4538	Pantoprazole sodium Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。
S2105	Pantoprazole Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。	Front Microbiol,2019, 10:2790
S5058	Revaprazan Hydrochloride Revaprazan Hydrochloride (YH1885) 是一种新型可逆的proton pump抑制剂，具有长效抑酸活性。Revaprazan Hydrochloride 通过结合泵上K+结合位点来可逆性地抑制 H(+)/K(+)-ATPase。

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