AChE 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S9219 Huperzine B

Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.

S3820 Dehydroevodiamine hydrochloride

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

S5073 Donepezil

Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.

Selective AChE, IC50: 6.7 nM
S2251 (-)-Huperzine A (HupA)

(-)-Huperzine A (HupA)是一种有效的,高度特异性的,可逆acetylcholinesterase (AChE)(乙酰胆碱酯酶)抑制剂,Ki为7 nM,作用于G4 AChE比作用于G1 AChE选择性高200倍。Phase 4。

Selective AChE (G4 form), Ki: 7 nM
S2462 Donepezil HCl

Donepezil HCl 是一种特异性的,有效的AChE抑制剂,作用于bAChEhAChEIC50分别为8.12 nM和11.6 nM。

Selective hAChE, IC50: 11.6 nM; bAChE, IC50: 8.12 nM
S4357 Tacrine HCl

Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist.

Selective AChE, IC50: 31 nM
S3866 Galanthamine

Galanthamine (Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.

Selective AChE, IC50: 0.35 μM
S1339 Galanthamine HBr

Galanthamine HBr是一种AChE抑制剂,IC50为0.35 μM,比作用于丁酰胆碱酯酶选择性高50倍。

Selective AChE, IC50: 0.35 μM
S3769 Palmatine

Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.

Selective AChE, IC50: 0.51 μM
S3884 Jatrorrhizine

Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.

Selective AChE, IC50: 872 nM
S9069 Jatrorrhizine chloride

Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.

Selective AChE, IC50: 872 nM
S4619 Itopride hydrochloride

Itopride hydrochloride是一种AChE抑制剂。其IC50为2.04 +/- 0.27 μM。

Selective AChE, IC50: 2.04 μM
S5075 Acotiamide

Acotiamide (Acofide, Z388) is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.

Selective AChE, IC50: 3 μM
S3835 Loganin

Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.

Selective AChE, IC50: 3.95 μM
S3904 Isoimperatorin

Isoimperatorin, a natural furanocoumarin that can be isolated from a variety of plant parts, has analgesic, antimicrobial, vascular relaxing and anticancer activities. Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.

Selective AChE, IC50: 74.6 μM
S9260 Nodakenin

Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.

Selective AChE, IC50: 84.7 μM
S3245 Nodakenetin

Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.

S3246 Picfeltarraenin IB

Picfeltarraenin IB, a cucurbitacin glycoside isolated from Picriafel-terrae, is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.