AChR

信号通路图

研究领域

抑制剂选择性比较

特异性亚型抑制剂

AChR产品

新AChR产品
产品目录 产品描述 文献引用 实验数据
S2462

Donepezil HCl

Donepezil HCl 是一种特异性的,有效的AChE抑制剂,作用于bAChEhAChEIC50分别为8.12 nM和11.6 nM。

S2251

(-)-Huperzine A (HupA)

(-)-Huperzine A (HupA)是一种有效的,高度特异性的,可逆acetylcholinesterase (AChE)(乙酰胆碱酯酶)抑制剂,Ki为7 nM,作用于G4 AChE比作用于G1 AChE选择性高200倍。Phase 4。

S5886New

Hodostin

Hodostin是acetylcholinesterase (AChE)的可逆性抑制剂,不能穿透血脑屏障,用于治疗重症肌无力。

S5900New

Edrophonium chloride

Edrophonium chloride是edrophonium的氯盐形式。Edrophonium是一种快速起效、短效、易可逆的acetylcholinesterase (乙酰胆碱酯酶)抑制剂。

S9252New

Corydaline

Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.

S9260New

Nodakenin

Nodakenin, a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.

S9219New

Huperzine B

Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.

s9138New

Picfeltarraenin IA

Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.

S9154New

Chelidonine

Chelidonine, a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity.

s9087New

Tenuifolin

Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.

s9069New

Jatrorrhizine chloride

Jatrorrhizine chloride is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.

S2452

Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl是一种选择性去甲肾上腺素-多巴胺再摄取的抑制剂,IC50分别为6.5和3.4μM。

S1339

Galanthamine HBr

Galanthamine HBr是一种AChE抑制剂,IC50为0.35 μM,比作用于丁酰胆碱酯酶选择性高50倍。

S4031

Aclidinium Bromide

Aclidinium Bromide与人源毒蕈碱受体AChR M1, M2, M3, M4和M5结合,Ki值分别为0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM和0.16 nM。

S1397

Rocuronium Bromide

Rocuronium Bromide是一种氨基甾体类非去极化的神经肌肉受体抑制剂或肌肉松弛剂。

S3047

Otilonium Bromide

Otilonium Bromide是一种抗毒蕈碱药物.

S2471

Gallamine Triethiodide

Gallamine Triethiodide 是一种胆碱能受体抑制剂,IC50为68.0±8.4 μM。

S1608

Pyridostigmine Bromide

Pyridostigmine Bromide 是一种拟副交感神经的和可逆的胆碱酯酶抑制剂。

S2087

Rivastigmine Tartrate

Rivastigmine Tartrate是一种胆碱酯酶抑制剂,IC50为5.5 μM,作为副交感神经或胆碱能剂,用于治疗轻度至中度阿尔茨海默病。

S1929

Irsogladine

Irsogladine是一种抗胃溃疡剂,通过M1 muscarininc乙酰胆碱受体结合,有利于细胞间隙连接通讯。

S2490

Neostigmine Bromide

Neostigmine Bromide 是一种可逆的胆碱酯酶抑制剂。

S3202

Catharanthine

Catharanthine是一种从长春花中分离出来的生物碱,可以抑制烟碱受体介导的隔膜收缩,IC50为59.6µM。

S5073

Donepezil

Donepezil是一种有效的、可逆的、特异的和非竞争性acetylcholinesterase (AChE)抑制剂,用于治疗轻度至中度痴呆。

S4014

Hyoscyamine

Hyoscyamine是一种AChR抑制剂,IC50为7.5nM。

S4023

Procaine HCl

Procaine HCl是一种钠离子通道的,NMDA受体以及乙酰胆碱受体抑制剂, IC50分别为60 μM, 0.296 mM何45.5 μM,也是一种,5-HT3抑制剂,KD为1.7 μM。

S3820

Dehydroevodiamine hydrochloride

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

S1832

Atracurium Besylate

Atracurium Besylate是一种神经肌肉抑制剂,ED95为0.2 mg/kg。

S3835

Loganin

Loganin is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.

S4619

Itopride hydrochloride

Itopride hydrochloride是一种AChE抑制剂。其IC50为2.04 +/- 0.27 μM。

S4162

Benzethonium Chloride

Benzethonium chloride 是有效的neuronal nicotinic acetylcholine receptors (nAChRs)(神经元烟碱型乙酰胆碱受体)抑制剂,抑制α4β2 nAChRsα7 nAChRsIC50分别为49 nM 和 122 nM。

S3639

Tacrine hydrochloride hydrate

Tacrine是胆碱酯酶(cholinesterase)抑制剂,可对抗骨骼肌松弛药的作用,可作为呼吸兴奋剂并用于治疗阿兹海默病和其他中枢神经系统障碍。它也是组胺N-甲基转移酶(histamine N-methyltransferase)抑制剂。

S3662

Pirenzepine dihydrochloride

Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.

S3769

Palmatine

Palmatine, an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.

S3884

Jatrorrhizine

Jatrorrhizine, one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.

S4505

Vinblastine sulfate

Vinblastine sulfate抑制微管形成nAChR活性,在无细胞实验的测定中,IC50为8.9 μM。

S5075

Acotiamide

Acotiamide是一种新型的乙酰胆碱酯酶(AChE)抑制剂,具有促胃动力和眼底松弛的效果。

S4687

Rivastigmine

Rivastigmine是一种胆碱酯酶的抑制剂,IC50为5.5 μM。它抑制乙酰胆碱酯酶(IC50=4.15 µM)和丁酰胆碱酯酶(IC50=37 nM)。

S4776

Harmaline

Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase.

S3903

Lycorine

Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.

S4542

Trihexyphenidyl hydrochloride

Trihexyphenidyl hydrochloride是一种抗毒蕈碱类的抗帕金森病药物。

S5511

Ethyl (triphenylphosphoranylidene) acetate

Ethyl (triphenylphosphoranylidene) acetate may act as an inhibitor of cholinesterase that inhibits AChE and BChE.

S2082

Adiphenine HCl

Adiphenine HCl 是一种烟碱受体抑制剂,IC50为15 µM,用作解痉药。

S3866

Galanthamine

Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.

S4838

Acotiamide hydrochloride

Acotiamide Hydrochloride是acotiamide的盐酸形式,acotiamide是一种肠蠕动促进剂。它是一种新型的、具有口服活性的、选择性的AChE抑制剂。

S5493

Atropine sulfate

Atropine Sulfate is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.

S4575

Pralidoxime chloride

Pralidoxime是有机磷农药和一些化学制品的解毒剂。是AChE的重新激活剂。

S5100

Pralidoxime Iodide

Pralidoxime Iodide (2-PAM)是一种解毒剂,有机磷中毒后可重新激活被抑制的AChE。

S2547

Tiotropium Bromide hydrate

Tiotropium Bromide hydrate是Tiotropium bromide (Spiriva; Tiova; BA 679BR; Tiopropium)的一水合物,是抗胆碱药,支气管扩张剂及毒蕈碱受体拮抗剂。

S2497

Pancuronium dibromide

Pancuronium dibromide是一种竞争性的乙酰胆碱受体拮抗剂,用作肌肉松弛剂。

S2550

Tolterodine tartrate

Tolterodine tartrate是Tolterodine的酒石酸盐形式,是一种竞争性的毒蕈碱型乙酰胆碱受体拮抗剂。

S5921New

Cyclopentolate Hydrochloride

Cyclopentolate是毒蝇碱型乙酰胆碱受体拮抗剂,对M1、M2和M3受体的Ki值分别为1.62, 27.5和2.63 nM。

S6469New

Thonzylamine

Thonzylamine是抗组胺剂和抗胆碱能药。

S5873New

Scopolamine HBr trihydrate

S5699New

Scopolamine N-Oxide HydrobroMide Monohydrate

Scopolamine N-Oxide是毒蕈碱拮抗剂,用于研究m型胆碱能受体的结合特性。

S5238New

Solifenacin (YM905)

Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

S2240

Fesoterodine Fumarate

Fesoterodine Fumarate 是毒蕈碱受体拮抗剂5-羟甲基托特罗定的前药,用来治疗膀胱过度活动症。

S1754

Oxybutynin

Oxybutynin 是一种竞争性的muscarinic acetylcholine receptorM1,M2,和M3拮抗剂,用于减少尿量,减轻膀胱负担。

S3048

Solifenacin succinate

Solifenacin succinate是一种抗毒蕈碱类泌尿解痉药。

S1683

Ipratropium Bromide

Ipratropium bromide是毒蕈碱拮抗剂,支气管扩张剂,是AtropineN的异丙基盐。

S2549

Trospium chloride

Trospium chloride 是一种竞争性的毒蕈碱型乙酰胆碱受体拮抗剂。

S2130

Atropine sulfate monohydrate

Atropine sulfate monohydrate是一种竞争性毒蕈碱型乙酰胆碱受体拮抗剂,IC50为2.5 nM。

S1978

Methscopolamine

Methscopolamine是一种毒蕈碱型乙酰胆碱受体抑制剂。

S2508

Scopolamine HBr

Scopolamine HBr是一种竞争性的毒蕈碱型乙酰胆碱受体拮抗剂,IC50为55.3 ± 4.3 nM。

S2659

5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)

5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)是一种新的蕈毒碱受体拮抗剂,Kb为0.84 nM.

S3144

Darifenacin HBr

Darifenacin HBr是一种选择性的M3 muscarinic(M3蕈毒碱)受体拮抗剂,pKi为8.9。

S5480

Clidinium Bromide

Clidinium Bromide is an anticholinergic drug.

S4024

Homatropine Methylbromide

Homatropine Methylbromide是一种毒蕈碱受体AChR拮抗剂,抑制WKY-E和SHR-E , IC50分别为162.5 nM和170.3 nM。

S4025

Homatropine Bromide

Homatropine Bromide是一种毒蕈碱受体AChR拮抗剂,抑制WKY-E和SHR-E , IC50分别为162.5 nM和170.3 nM。

S4027

Flavoxate HCl

Flavoxate HCl是一种毒蕈碱受体AChR拮抗剂, IC50为12.2 μM.

S5258

Revefenacin

Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.

S2054

Orphenadrine Citrate

Orphenadrine citrate 是一种骨骼肌松弛剂,作用于中枢神经系统,产生肌肉松弛作用。

S4034

Diphemanil Methylsulfate

Diphemanil Methylsulfate是一种季铵抗胆碱能药剂,可以结合毒蕈碱型乙酰胆碱受体(mAchR)。

S4143

Pentoxyverine Citrate

Pentoxyverine Citrate 是antitussive(止咳药),通常用于治疗咳嗽相关的疾病,如感冒。

S3701

Benactyzine hydrochloride

Benactyzine hydrochloride是中枢性毒蕈碱受体拮抗剂。在抑郁症和相关焦虑的治疗中,它被用作抗抑郁剂。

S4623

Methylbenactyzine Bromide

Methylbenactyzine Bromide是一种毒蕈硷胆碱能受体拮抗剂,具有解痉活性。

S4069

Hexamethonium Dibromide

Hexamethonium Dibromide是一种神经中枢中选择性的神经元烟碱型AChR选择性拮抗剂。

S4660

Glycopyrrolate

Glycopyrrolate是毒蕈碱拮抗剂。在胃肠道疾病中,被用作止痉挛药。

S3735

Umeclidinium bromide

Umeclidinium bromide是一种长效毒蕈碱拮抗剂,对治疗慢性阻塞性肺疾病具有持续性疗效。

S5538

Tropisetron

Tropisetron is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

S3117

Oxybutynin hydrochloride

Oxybutynin chloride是一种抗胆碱药,用于缓解尿和膀胱负担。

S4834

Propantheline bromide

Propantheline bromide是一种毒蕈碱拮抗剂,用于治疗和肠痉挛相关的胃肠道疾病、在麻醉过程中减少分泌。

S4992

Nanofin

Nanofin is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.

S4292

Diphenidol HCl

Diphenidol HCl是一种有效的muscarinic M2 and M3 receptor拮抗剂,pKb分别为6.72和7.02,用于呕吐和晕眩的治疗。

S1913

Tropicamide

Tropicamide是一种抗胆碱,毒蕈碱受体M4亚型的选择性拮抗剂,IC50为8.0 nM。

S6432New

Cevimeline

Cevimeline是一种拟副交感神经药,是毒蕈碱样乙酰胆碱受体M1和M3的激动剂。

S5930New

PNU 282987

PNU 282987是一种有效的含α7的神经元烟碱受体(α7-containing neuronal nicotinic acetylcholine receptors)激动剂,对大鼠受体的Ki值为26 nM。

S1805New

Acetylcholine Chloride

化合物Acetylcholine Chloride是一种神经递质,作用于包括人类在内的许多生物的周围神经系统(PNS)和中枢神经系统(CNS)。

S1440

Varenicline Tartrate

Varenicline Tartrate是一种烟碱类AChR激动剂,用于治疗吸烟成瘾。

S2455

Bethanechol chloride

Bethanechol chloride是一种选择性毒蕈碱受体激动剂,对烟碱受体没有任何效果。

S2614

Arecoline HBr

Arecoline是一种毒蕈碱型乙酰胆碱受体激动剂。

S4231

Pilocarpine HCl

Pilocarpine HCl 是非选择性毒蕈碱型乙酰胆碱受体激动剂,用于产生癫痫的实验模型。

S4121

Succinylcholine Chloride Dihydrate

Succinylcholine Chloride Dihydrate是一种烟碱AChR激动剂,同时也是一种去极化神经肌肉阻断剂。

S4422

Nitenpyram

Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂,用于兽医对家畜和宠物寄生虫的治疗。

S7366

LY2119620

LY2119620是一种人类M2 and M4 muscarinic acetylcholine receptors的特异变构激动剂。

S2287

Cytisine

Cytisine是一种烟碱型乙酰胆碱受体激动剂。

S4171

Choline Chloride

Choline chloride是一种季铵盐,作为动物饲料添加剂。它是acetylcholine的前体化合物,在多种代谢过程、脂质代谢中作为甲基供体。

S4072

Decamethonium Bromide

Decamethonium Bromide是一种烟碱AChR部分激动剂和神经肌肉阻断剂。

S3684

Methacholine chloride

Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.

S4718

Acetylcholine iodide

Acetylcholine iodide是一种存在于肌肉神经接点、自主神经节、副交感效应连接处以及中枢神经系统很多地方的神经递质。

S5844New

Lobelin sulphate

Lobelin sulphate对烟碱性胆碱能受体具有与尼古丁类似的作用。它应用于多种疾病的治疗,如呼吸道疾病、周围性血管疾病、失眠症以及戒烟过程。

S5931New

BQCA

BQCA是一种高选择性M1 muscarinic acetylcholine receptor (mAChR)正向别构调节剂。

S5747New

Morantel tartrate

Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs).

S2629

PNU-120596

PNU-120596是一种有效的α7 nAChR变构调节剂,EC50为216 nM。

S3972

Lobeline hydrochloride

Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.

S9560New

Anisodamine Hydrobromide

Anisodamine是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptorsmAChRs

S1405

Vecuronium Bromide

Vecuronium Bromide 是一种肌肉松弛剂,属于非去极化抑制剂。

S4617

Dextromethorphan hydrobromide hydrate

Dextromethorphan是一种吗啡喃类的止咳药,在高浓度下具有镇静、解离、兴奋特性。

产品目录 产品描述 文献引用 实验数据
S2462

Donepezil HCl

Donepezil HCl 是一种特异性的,有效的AChE抑制剂,作用于bAChEhAChEIC50分别为8.12 nM和11.6 nM。

S2251

(-)-Huperzine A (HupA)

(-)-Huperzine A (HupA)是一种有效的,高度特异性的,可逆acetylcholinesterase (AChE)(乙酰胆碱酯酶)抑制剂,Ki为7 nM,作用于G4 AChE比作用于G1 AChE选择性高200倍。Phase 4。

S5886New

Hodostin

Hodostin是acetylcholinesterase (AChE)的可逆性抑制剂,不能穿透血脑屏障,用于治疗重症肌无力。

S5900New

Edrophonium chloride

Edrophonium chloride是edrophonium的氯盐形式。Edrophonium是一种快速起效、短效、易可逆的acetylcholinesterase (乙酰胆碱酯酶)抑制剂。

S9252New

Corydaline

Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.

S9260New

Nodakenin

Nodakenin, a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.

S9219New

Huperzine B

Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.

s9138New

Picfeltarraenin IA

Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.

S9154New

Chelidonine

Chelidonine, a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity.

s9087New

Tenuifolin

Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.

s9069New

Jatrorrhizine chloride

Jatrorrhizine chloride is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.

S2452

Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl是一种选择性去甲肾上腺素-多巴胺再摄取的抑制剂,IC50分别为6.5和3.4μM。

S1339

Galanthamine HBr

Galanthamine HBr是一种AChE抑制剂,IC50为0.35 μM,比作用于丁酰胆碱酯酶选择性高50倍。

S4031

Aclidinium Bromide

Aclidinium Bromide与人源毒蕈碱受体AChR M1, M2, M3, M4和M5结合,Ki值分别为0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM和0.16 nM。

S1397

Rocuronium Bromide

Rocuronium Bromide是一种氨基甾体类非去极化的神经肌肉受体抑制剂或肌肉松弛剂。

S3047

Otilonium Bromide

Otilonium Bromide是一种抗毒蕈碱药物.

S2471

Gallamine Triethiodide

Gallamine Triethiodide 是一种胆碱能受体抑制剂,IC50为68.0±8.4 μM。

S1608

Pyridostigmine Bromide

Pyridostigmine Bromide 是一种拟副交感神经的和可逆的胆碱酯酶抑制剂。

S2087

Rivastigmine Tartrate

Rivastigmine Tartrate是一种胆碱酯酶抑制剂,IC50为5.5 μM,作为副交感神经或胆碱能剂,用于治疗轻度至中度阿尔茨海默病。

S1929

Irsogladine

Irsogladine是一种抗胃溃疡剂,通过M1 muscarininc乙酰胆碱受体结合,有利于细胞间隙连接通讯。

S2490

Neostigmine Bromide

Neostigmine Bromide 是一种可逆的胆碱酯酶抑制剂。

S3202

Catharanthine

Catharanthine是一种从长春花中分离出来的生物碱,可以抑制烟碱受体介导的隔膜收缩,IC50为59.6µM。

S5073

Donepezil

Donepezil是一种有效的、可逆的、特异的和非竞争性acetylcholinesterase (AChE)抑制剂,用于治疗轻度至中度痴呆。

S4014

Hyoscyamine

Hyoscyamine是一种AChR抑制剂,IC50为7.5nM。

S4023

Procaine HCl

Procaine HCl是一种钠离子通道的,NMDA受体以及乙酰胆碱受体抑制剂, IC50分别为60 μM, 0.296 mM何45.5 μM,也是一种,5-HT3抑制剂,KD为1.7 μM。

S3820

Dehydroevodiamine hydrochloride

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

S1832

Atracurium Besylate

Atracurium Besylate是一种神经肌肉抑制剂,ED95为0.2 mg/kg。

S3835

Loganin

Loganin is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.

S4619

Itopride hydrochloride

Itopride hydrochloride是一种AChE抑制剂。其IC50为2.04 +/- 0.27 μM。

S4162

Benzethonium Chloride

Benzethonium chloride 是有效的neuronal nicotinic acetylcholine receptors (nAChRs)(神经元烟碱型乙酰胆碱受体)抑制剂,抑制α4β2 nAChRsα7 nAChRsIC50分别为49 nM 和 122 nM。

S3639

Tacrine hydrochloride hydrate

Tacrine是胆碱酯酶(cholinesterase)抑制剂,可对抗骨骼肌松弛药的作用,可作为呼吸兴奋剂并用于治疗阿兹海默病和其他中枢神经系统障碍。它也是组胺N-甲基转移酶(histamine N-methyltransferase)抑制剂。

S3662

Pirenzepine dihydrochloride

Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.

S3769

Palmatine

Palmatine, an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.

S3884

Jatrorrhizine

Jatrorrhizine, one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.

S4505

Vinblastine sulfate

Vinblastine sulfate抑制微管形成nAChR活性,在无细胞实验的测定中,IC50为8.9 μM。

S5075

Acotiamide

Acotiamide是一种新型的乙酰胆碱酯酶(AChE)抑制剂,具有促胃动力和眼底松弛的效果。

S4687

Rivastigmine

Rivastigmine是一种胆碱酯酶的抑制剂,IC50为5.5 μM。它抑制乙酰胆碱酯酶(IC50=4.15 µM)和丁酰胆碱酯酶(IC50=37 nM)。

S4776

Harmaline

Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase.

S3903

Lycorine

Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.

S4542

Trihexyphenidyl hydrochloride

Trihexyphenidyl hydrochloride是一种抗毒蕈碱类的抗帕金森病药物。

S5511

Ethyl (triphenylphosphoranylidene) acetate

Ethyl (triphenylphosphoranylidene) acetate may act as an inhibitor of cholinesterase that inhibits AChE and BChE.

S2082

Adiphenine HCl

Adiphenine HCl 是一种烟碱受体抑制剂,IC50为15 µM,用作解痉药。

S3866

Galanthamine

Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.

S4838

Acotiamide hydrochloride

Acotiamide Hydrochloride是acotiamide的盐酸形式,acotiamide是一种肠蠕动促进剂。它是一种新型的、具有口服活性的、选择性的AChE抑制剂。

S5493

Atropine sulfate

Atropine Sulfate is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.

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S4575

Pralidoxime chloride

Pralidoxime是有机磷农药和一些化学制品的解毒剂。是AChE的重新激活剂。

S5100

Pralidoxime Iodide

Pralidoxime Iodide (2-PAM)是一种解毒剂,有机磷中毒后可重新激活被抑制的AChE。

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S2547

Tiotropium Bromide hydrate

Tiotropium Bromide hydrate是Tiotropium bromide (Spiriva; Tiova; BA 679BR; Tiopropium)的一水合物,是抗胆碱药,支气管扩张剂及毒蕈碱受体拮抗剂。

S2497

Pancuronium dibromide

Pancuronium dibromide是一种竞争性的乙酰胆碱受体拮抗剂,用作肌肉松弛剂。

S2550

Tolterodine tartrate

Tolterodine tartrate是Tolterodine的酒石酸盐形式,是一种竞争性的毒蕈碱型乙酰胆碱受体拮抗剂。

S5921New

Cyclopentolate Hydrochloride

Cyclopentolate是毒蝇碱型乙酰胆碱受体拮抗剂,对M1、M2和M3受体的Ki值分别为1.62, 27.5和2.63 nM。

S6469New

Thonzylamine

Thonzylamine是抗组胺剂和抗胆碱能药。

S5873New

Scopolamine HBr trihydrate

S5699New

Scopolamine N-Oxide HydrobroMide Monohydrate

Scopolamine N-Oxide是毒蕈碱拮抗剂,用于研究m型胆碱能受体的结合特性。

S5238New

Solifenacin (YM905)

Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

S2240

Fesoterodine Fumarate

Fesoterodine Fumarate 是毒蕈碱受体拮抗剂5-羟甲基托特罗定的前药,用来治疗膀胱过度活动症。

S1754

Oxybutynin

Oxybutynin 是一种竞争性的muscarinic acetylcholine receptorM1,M2,和M3拮抗剂,用于减少尿量,减轻膀胱负担。

S3048

Solifenacin succinate

Solifenacin succinate是一种抗毒蕈碱类泌尿解痉药。

S1683

Ipratropium Bromide

Ipratropium bromide是毒蕈碱拮抗剂,支气管扩张剂,是AtropineN的异丙基盐。

S2549

Trospium chloride

Trospium chloride 是一种竞争性的毒蕈碱型乙酰胆碱受体拮抗剂。

S2130

Atropine sulfate monohydrate

Atropine sulfate monohydrate是一种竞争性毒蕈碱型乙酰胆碱受体拮抗剂,IC50为2.5 nM。

S1978

Methscopolamine

Methscopolamine是一种毒蕈碱型乙酰胆碱受体抑制剂。

S2508

Scopolamine HBr

Scopolamine HBr是一种竞争性的毒蕈碱型乙酰胆碱受体拮抗剂,IC50为55.3 ± 4.3 nM。

S2659

5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)

5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)是一种新的蕈毒碱受体拮抗剂,Kb为0.84 nM.

S3144

Darifenacin HBr

Darifenacin HBr是一种选择性的M3 muscarinic(M3蕈毒碱)受体拮抗剂,pKi为8.9。

S5480

Clidinium Bromide

Clidinium Bromide is an anticholinergic drug.

S4024

Homatropine Methylbromide

Homatropine Methylbromide是一种毒蕈碱受体AChR拮抗剂,抑制WKY-E和SHR-E , IC50分别为162.5 nM和170.3 nM。

S4025

Homatropine Bromide

Homatropine Bromide是一种毒蕈碱受体AChR拮抗剂,抑制WKY-E和SHR-E , IC50分别为162.5 nM和170.3 nM。

S4027

Flavoxate HCl

Flavoxate HCl是一种毒蕈碱受体AChR拮抗剂, IC50为12.2 μM.

S5258

Revefenacin

Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.

S2054

Orphenadrine Citrate

Orphenadrine citrate 是一种骨骼肌松弛剂,作用于中枢神经系统,产生肌肉松弛作用。

S4034

Diphemanil Methylsulfate

Diphemanil Methylsulfate是一种季铵抗胆碱能药剂,可以结合毒蕈碱型乙酰胆碱受体(mAchR)。

S4143

Pentoxyverine Citrate

Pentoxyverine Citrate 是antitussive(止咳药),通常用于治疗咳嗽相关的疾病,如感冒。

S3701

Benactyzine hydrochloride

Benactyzine hydrochloride是中枢性毒蕈碱受体拮抗剂。在抑郁症和相关焦虑的治疗中,它被用作抗抑郁剂。

S4623

Methylbenactyzine Bromide

Methylbenactyzine Bromide是一种毒蕈硷胆碱能受体拮抗剂,具有解痉活性。

S4069

Hexamethonium Dibromide

Hexamethonium Dibromide是一种神经中枢中选择性的神经元烟碱型AChR选择性拮抗剂。

S4660

Glycopyrrolate

Glycopyrrolate是毒蕈碱拮抗剂。在胃肠道疾病中,被用作止痉挛药。

S3735

Umeclidinium bromide

Umeclidinium bromide是一种长效毒蕈碱拮抗剂,对治疗慢性阻塞性肺疾病具有持续性疗效。

S5538

Tropisetron

Tropisetron is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

S3117

Oxybutynin hydrochloride

Oxybutynin chloride是一种抗胆碱药,用于缓解尿和膀胱负担。

S4834

Propantheline bromide

Propantheline bromide是一种毒蕈碱拮抗剂,用于治疗和肠痉挛相关的胃肠道疾病、在麻醉过程中减少分泌。

S4992

Nanofin

Nanofin is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.

S4292

Diphenidol HCl

Diphenidol HCl是一种有效的muscarinic M2 and M3 receptor拮抗剂,pKb分别为6.72和7.02,用于呕吐和晕眩的治疗。

S1913

Tropicamide

Tropicamide是一种抗胆碱,毒蕈碱受体M4亚型的选择性拮抗剂,IC50为8.0 nM。

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S6432New

Cevimeline

Cevimeline是一种拟副交感神经药,是毒蕈碱样乙酰胆碱受体M1和M3的激动剂。

S5930New

PNU 282987

PNU 282987是一种有效的含α7的神经元烟碱受体(α7-containing neuronal nicotinic acetylcholine receptors)激动剂,对大鼠受体的Ki值为26 nM。

S1805New

Acetylcholine Chloride

化合物Acetylcholine Chloride是一种神经递质,作用于包括人类在内的许多生物的周围神经系统(PNS)和中枢神经系统(CNS)。

S1440

Varenicline Tartrate

Varenicline Tartrate是一种烟碱类AChR激动剂,用于治疗吸烟成瘾。

S2455

Bethanechol chloride

Bethanechol chloride是一种选择性毒蕈碱受体激动剂,对烟碱受体没有任何效果。

S2614

Arecoline HBr

Arecoline是一种毒蕈碱型乙酰胆碱受体激动剂。

S4231

Pilocarpine HCl

Pilocarpine HCl 是非选择性毒蕈碱型乙酰胆碱受体激动剂,用于产生癫痫的实验模型。

S4121

Succinylcholine Chloride Dihydrate

Succinylcholine Chloride Dihydrate是一种烟碱AChR激动剂,同时也是一种去极化神经肌肉阻断剂。

S4422

Nitenpyram

Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂,用于兽医对家畜和宠物寄生虫的治疗。

S7366

LY2119620

LY2119620是一种人类M2 and M4 muscarinic acetylcholine receptors的特异变构激动剂。

S2287

Cytisine

Cytisine是一种烟碱型乙酰胆碱受体激动剂。

S4171

Choline Chloride

Choline chloride是一种季铵盐,作为动物饲料添加剂。它是acetylcholine的前体化合物,在多种代谢过程、脂质代谢中作为甲基供体。

S4072

Decamethonium Bromide

Decamethonium Bromide是一种烟碱AChR部分激动剂和神经肌肉阻断剂。

S3684

Methacholine chloride

Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.

S4718

Acetylcholine iodide

Acetylcholine iodide是一种存在于肌肉神经接点、自主神经节、副交感效应连接处以及中枢神经系统很多地方的神经递质。

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S5844New

Lobelin sulphate

Lobelin sulphate对烟碱性胆碱能受体具有与尼古丁类似的作用。它应用于多种疾病的治疗,如呼吸道疾病、周围性血管疾病、失眠症以及戒烟过程。

S5931New

BQCA

BQCA是一种高选择性M1 muscarinic acetylcholine receptor (mAChR)正向别构调节剂。

S5747New

Morantel tartrate

Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs).

S2629

PNU-120596

PNU-120596是一种有效的α7 nAChR变构调节剂,EC50为216 nM。

S3972

Lobeline hydrochloride

Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.

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S9560New

Anisodamine Hydrobromide

Anisodamine是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptorsmAChRs

S1405

Vecuronium Bromide

Vecuronium Bromide 是一种肌肉松弛剂,属于非去极化抑制剂。

S4617

Dextromethorphan hydrobromide hydrate

Dextromethorphan是一种吗啡喃类的止咳药,在高浓度下具有镇静、解离、兴奋特性。