| S1739 |
Thiabendazole |
Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property, used as an anthelmintic and fungicide agent. It is a potent inhibitor of cytochrome P450 1A2 (CYP1A2). |
Selective |
|
| S0176 |
DMU2139 |
DMU2139 is a potent and specific inhibitor of CYP1B1 with IC50 of 9 nM. |
Selective |
CYP1B1, IC50: 9 nM |
| S0175 |
DMU2105 |
DMU2105 is a potent and specific inhibitor of CYP1B1 with IC50 of 10 nM. |
Selective |
CYP1B1, IC50: 10 nM |
| S5380 |
7-Hydroxyflavone |
7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines. |
Selective |
CYP1A1, Ki: 0.015 μM |
| S9163 |
Rhapontigenin |
Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM). |
Selective |
CYP1A1, IC50: 400 nM |
| S2526 |
Alizarin |
Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
Selective |
CYP1A1, IC50: 6.2 μM; CYP1A2, IC50: 10.0 μM; CYP1B1, IC50: 2.7 μM |
| S0418 |
Ezutromid |
Ezutromid (SMT C1100,BMN 195,VOX-C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM which can be used for the research Duchenne muscular dystrophy (DMD), also inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM. |
Selective |
CYP1A2, IC50: 5.4 μM |
| S2394 |
Naringenin |
Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. |
Selective |
|
| S3291 |
Myristicin |
Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2. |
Selective |
|
| S2380 |
Diosmetin |
Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants. |
Selective |
|
| S2187 |
Avasimibe |
Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively. |
Pan |
CYP1A2, IC50: 13.9 μM |
| S3931 |
Ginsenoside Rd |
Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP |
Pan |
CYP1A2, IC50: 78.4 μM |
