P2Y receptor 选择性抑制剂 | 激动剂 | 拮抗剂 | 调节剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S4637 Prasugrel Hydrochloride

Prasugrel hydrochloride是一种哌嗪衍生物,是血小板聚集抑制剂,在急性冠脉综合征患者中阻止血栓形成。

Selective
S3737 Cangrelor Tetrasodium

Cangrelor (AR-C69931MX) is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.

Selective
S4079 Ticagrelor

Ticagrelor是第一个口服的可以可逆结合的P2Y12受体拮抗剂。

Selective P2Y12, Ki: 2 nM
S2855 MRS 2578

MRS 2578是一种有效的P2Y6受体抑制剂,IC50为37 nM,对P2Y1, P2Y2, P2Y4和P2Y11受体的作用活性很弱。

Selective P2Y6, IC50: 37 nM
S1415 Clopidogrel (SR-25990C) Bisulfate

Clopidogrel是一种口服的,噻吩吡啶类抗血小板药物。

Selective
S3216 Uridine 5'-diphosphoglucose disodium salt

Uridine-5'-diphosphoglucose (UDPG, UDP-Glc, UDP-D-Glucose, UDP-α-D-Glucose) activates the P2Y(14) receptor, a neuroimmune system GPCR. Uridine-5'-diphosphoglucose is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms.

Selective
S1258 Prasugrel

Prasugrel是一种噻吩吡啶类的ADP receptor (P2Y12) 拮抗剂,用于降低血栓相关的心血管紊乱。

Selective
S3293 Gardenoside

Gardenoside is a natural compound extracted from Gardenia fruits, with hepatoprotective properties. Gardenoside inhibits TNF-α, IL-1β, IL-6 and NFκB activation. Gardenoside also has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors.

Pan