• Cdc42-subclass
  • Rac
  • Rho-subclass

Rac 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S7482 EHT 1864 2HCl EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. Selective Rac1, Kd: 40 nM; Rac2, Kd: 60 nM; Rac1b, Kd: 50 nM; Rac3, Kd: 250 nM
S7319 EHop-016 EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3. Selective Rac1, IC50: 1.1 μM
S8031 NSC 23766 NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. Selective Rac GTPase, IC50: 50 μM
S1721 Azathioprine Azathioprine(BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. Selective
S8749 MBQ-167 MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells. Pan Rac, IC50: 103 nM
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