Wnt 选择性抑制剂 | 调节剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S7981 CCT251545

CCT251545 is a potent, orally bioavailable inhibitor of WNT signaling with IC50 of 5 nM in 7dF3 cells. CCT251545 also act as a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Selective Wnt, IC50: 5 nM
S7085 IWP-2

IWP-2是一种Wnt信号和分泌抑制剂,无细胞试验中IC50为27 nM,选择性阻断Porcn介导的Wnt棕榈酰化,一般不影响Wnt/β-catenin,且对Wnt刺激的细胞反应没有影响。

Selective Wnt, IC50: 27 nM
S7086 IWR-1-endo

IWR-1-endo是一种Wnt通路抑制剂,在表达 Wnt3A 的 L-细胞中IC50为180 nM,诱导Axin2蛋白水平,并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。

Selective Wnt, IC50: 180 nM
S5992 Heparan Sulfate

Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.

S6745 JW55

JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).

S8761 Adavivint (SM04690)

Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.

S7096 KY02111