IWR-1-endo

For research use only. Not for use in humans.

目录号:S7086 别名: endo-IWR 1

IWR-1-endo Chemical Structure

CAS No. 1127442-82-3

IWR-1-endo (endo-IWR 1)是一种Wnt通路抑制剂,在表达 Wnt3A 的 L-细胞中IC50为180 nM,诱导Axin2蛋白水平,并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 975.58 现货
RMB 900.38 现货
RMB 2050.64 现货
RMB 5151.51 现货
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客户使用Selleck生产的IWR-1-endo发表文献64篇:

产品安全说明书

Wnt/beta-catenin抑制剂选择性比较

生物活性

产品描述 IWR-1-endo (endo-IWR 1)是一种Wnt通路抑制剂,在表达 Wnt3A 的 L-细胞中IC50为180 nM,诱导Axin2蛋白水平,并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。
靶点
Wnt [1]
(L-cells expressing Wnt3A)
180 nM
体外研究

IWR-1 和XAV939作为Wnt通路的可逆抑制剂,在体内外具有相似的药理作用,IWR-1通过与Axin相互作用而发挥效果,而XAV939直接与TNKS结合。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21 (DE3) NV32cm5NTnWwY4Tpc44h[XO|YYm= M2KxPVkxKG2rboO= M3ruV2FkfGm4aYT5JI9nKE5vdHXycYlvfXNiaHX4ZWhqey22YXfn[YQhcHWvYX6gWG5UUzJiZYjwdoV{e2WmIHnuJGV{[2incnnjbIliKGOxbHmgRmwzOSBqRFWzLUBk\WyuczD1d4lv\yCkaX;0bY56dGG2ZXSgUmFFMyCjczDzeYJ{fHKjdHWgZYZ1\XJiOUCgcYlveyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZMtKEWFNUCgQUAxNjJizszNMi=> NETRdFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKzN|MzOCd-MkKyN|M{OjB:L3G+
SW480 M4TTc2Z2dmO2aX;uJIF{e2G7 NETVNYMzPCCqcoO= M4m5UWlvcGmkaYTpc44hd2ZidHHub5lz[XOnIHnuJIh2dWGwIGPXOFgxKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDv[kBigGmwMjDh[pRmeiB{NDDodpMh[nliSH;lZ4h{fCCmeXWtZoF{\WRibXX0bI9lNCCHQ{WwJF0hOi53IN88UU4> NYrYc3JJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3NFE2OTdpPkKzO|AyPTF5PD;hQi=>
HEK293T MonYSpVv[3Srb36gZZN{[Xl? M4Lt[GlvcGmkaYTpc44hd2ZiYnX0ZU1k[XOnaX6t[IVx\W6mZX70JINidm:waXPhcEBYdnR|IIDheIh4[XliaX6gbJVu[W5iSFXLNlk{XCClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlAzPiEQvF2u MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF7MUW1O{c,OjJzOUG1OVc9N2F-
SW480 NGr0cGJHfW6ldHnvckBie3OjeR?= NX;RZW9DPDBidH:gOFghcHK| NF;CTHJKdmirYnn0bY9vKG:oIIThcot6emG|ZTDpckBpfW2jbjDTW|Q5OCClZXzsd{Bie3Onc4Pl[EBieyCmZXfyZYRifGmxbjDv[kBj\XSjIHPheIVvcW5iYX\0[ZIhPDBidH:gOFghcHK|LDDJR|UxKD1iMD6yOUDPxE1w NFTZ[HU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewNVUyPyd-MkO3NFE2OTd:L3G+
L-Wnt-STF NVXwS4h3TnWwY4Tpc44h[XO|YYm= MU[yOEBpenN? NGfWdHlKdmirYnn0bY9vKG:oIGTOT3MuOiCrbjDtc5V{\SCOLWfueE1UXEZiY3XscJMh[XO|ZYPz[YQh[XNiZHnzdpVxfGmxbjDv[kBYdnRic3nncoFtcW6pIHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlA2PiEQvF2u MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{N{e5Nkc,OjR3Mke3PVI9N2F-
L-Wnt-STF NH\JeolHfW6ldHnvckBie3OjeR?= M4XaflI1KGi{cx?= NI[0T4FKdmirYnn0bY9vKG:oIGTOT3MuOSCrbjDtc5V{\SCOLWfueE1UXEZiY3XscJMh[XO|ZYPz[YQh[XNiZHnzdpVxfGmxbjDv[kBYdnRic3nncoFtcW6pIHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlE{OSEQvF2u NFTiVIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyO|c6Oid-MkS1Nlc4QTJ:L3G+
HT29 NULneWZLTnWwY4Tpc44h[XO|YYm= NY\WbZlkOjRiaILz Mk[2TY5pcWKrdHnvckBw\iCZboSgd4lodmGuaX7nJIlvKGi3bXHuJGhVOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBj\XSjLXPheIVvcW5vbXXkbYF1\WRiVHPmM2xm\iC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkh[W[2ZYKgNlQhcHK|IHL5JIR2[WxibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5JJJmdGG2aY\lJJRwKGOxboTyc4wtKEmFNUCgQUAzPC52IN88UU4> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3MES4PUc,OjR7NUC0PFk9N2F-
DLD1 NEPBfphHfW6ldHnvckBie3OjeR?= M1XPTVExKHWP MVHJcoR2[3Srb36gc4YhSXirbkKgbY4hcHWvYX6gSGxFOSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDJW3IuUVNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hX262IIDheIh4[XliYXP0bZZqfHliYYSgNVAhfU1iYomgV3RHKHKncH;yeIVzKGG|c3H5JI1mfGixZB?= NEDFU2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOVE2Pid-MUmxNlUyPTZ:L3G+
HEK293 NYDZNldWTnWwY4Tpc44h[XO|YYm= MmDYSIl{eGyjY3Xt[Y51KG:oIFnXVk1RSiCocn;tJGF5cW5{IHnuJGhGUzJ7MzDj[YxteyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k NEjXeJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOVE2Pid-MUmxNlUyPTZ:L3G+
DLD1 MUfGeY5kfGmxbjDhd5NigQ>? MkDOTY5pcWKrdHnvckBw\iCDeHnuNkBxem:2ZXnuJIRm\3KjZHH0bY9vKGmwIHj1cYFvKESOREGgZ4VtdHNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF{NUG1Okc,OTlzMkWxOVY9N2F-
DLD1 NVLn[ZB{TnWwY4Tpc44h[XO|YYm= NVfRSGJ2UW6mdXP0bY9vKG:oIFH4bY4zKGGlY4XteYxifGmxbjDpckBpfW2jbjDEUGQyKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIGTodlQyKHCqb4PwbI9zgWyjdHXkJIJmfGFvY3Hz[YlvKGyndnXsd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MnHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMkWxOVYoRjF7MUK1NVU3RC:jPh?=
DLD1 NVPhbldFTnWwY4Tpc44h[XO|YYm= MVXJcoR2[3Srb36gc4YhSXirbkKgZYNkfW23bHH0bY9vKGmwIHj1cYFvKESOREGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hW2W{M{egdIhwe3Cqb4L5cIF1\WRiYnX0ZU1k[XOnaX6gcIV3\Wy|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF{NUG1Okc,OTlzMkWxOVY9N2F-
DLD1 Mn2wSpVv[3Srb36gZZN{[Xl? M2DuWGRm[3KnYYPlJIlvKGKndHGtZ4F{\WmwIHHjZ5VufWyjdHnvckBqdiCqdX3hckBFVERzIHPlcIx{KGW6cILld5NqdmdiaX6gRXBEKG23dHHueC=> M{PCeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK1NVU3Lz5zOUGyOVE2PjxxYU6=
DLD1 NIq0WYhHfW6ldHnvckBie3OjeR?= M3zCSlIhcHK| MWnJcoR2[3Srb36gc4YhSXirbkKgd5Ri[mmuaYrheIlwdiCrbjDoeY1idiCGTFSxJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPl[EB1emGwc3PybZB1cW:wIH;mJGF5cW5{IHHmeIVzKDJiaILzJIJ6KFKWLWDDVkBu\XSqb3S= M4\2e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK1NVU3Lz5zOUGyOVE2PjxxYU6=
DLD1 M3P5[2Z2dmO2aX;uJIF{e2G7 NFrlVFBKdmS3Y4Tpc44hd2ZiQYjpclIh[WOldX31cIF1cW:wIHnuJIh2dWGwIFTMSFEh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iZoLl[UBj\XSjLXPhd4VqdiCuZY\lcJMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF{NUG1Okc,OTlzMkWxOVY9N2F-
DLD1 MWDGeY5kfGmxbjDhd5NigQ>? MnfETY5lfWO2aX;uJI9nKEG6aX6yJJN1[WKrbHn6ZZRqd25iaX6gbJVu[W5iRFzENUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGfueE9j\XSjLXPhd4VqdiCyYYToe4F6 NF3IN3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOVE2Pid-MUmxNlUyPTZ:L3G+
DLD1 NW[3c41zTnWwY4Tpc44h[XO|YYm= M{D5NGlv\HWldHnvckBw\iCDeHnuNkBi[2O3bYXsZZRqd25iaX6gbJVu[W5iRFzENUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCVZYKzN{BxcG:|cHjvdplt[XSnZDDi[ZRiNWOjc3XpckBt\X[nbIOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF{NUG1Okc,OTlzMkWxOVY9N2F-
DLD1 NFPV[VZHfW6ldHnvckBie3OjeR?= NWLlNYVUUW6mdXP0bY9vKG:oIFH4bY4zKGGlY4XteYxifGmxbjDpckBpfW2jbjDEUGQyKGOnbHzzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NUCzSGx{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxNlUyPTZpPkG5NVI2OTV4PD;hQi=>
DLD1 MVnGeY5kfGmxbjDhd5NigQ>? MmXDNUB1dyB{MDD1US=> MVOyOEBpenN? NV;YOXViUW6qaXLpeIlwdiCxZjD0ZY5sgXKjc3WgbY4hcHWvYX6gSGxFOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHRETi2mZYDlcoRmdnRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGG2IEGgeI8hOjBidV2gZYZ1\XJiMkSgbJJ{KGK7IHT1ZYwhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 NXKydldpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1Nlc4QTJpPkK0OVI4Pzl{PD;hQi=>
DLD1 NHKxR5dEgXSxdH;4bYNqfHliYYPzZZk> NV3tbI8yOSC2bzCyNEB2VQ>? M1;SUlExKGSjeYO= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEUGQyKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGG2IEGgeI8hOjBidV2gcYVie3W{ZXSgc44h\GG7IEGwJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7n NVrTe5dNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1Nlc4QTJpPkK0OVI4Pzl{PD;hQi=>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
E-cadherin / N-cadherin / Snail / Vimentin; 

PubMed: 26450645     


Western blot analyses showing protein expression patterns of the EMT markers according to IWR-1 dose and exposure time. β-Actin was used as a loading control.

p-Akt / Akt; 

PubMed: 26450645     


Western blot analysis showing that IWR-1 decreased the phosphorylation of Akt in a concentration- and time-dependent manner, respectively.

Survivin; 

PubMed: 26450645     


Western blot analysis showing that IWR-1 decreased the survivin expression in a concentration- and time-dependent manner, respectively.

26450645

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 21 mg/mL (51.28 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 409.44
化学式

C25H19N3O3

CAS号 1127442-82-3
储存条件 粉状
溶于溶剂
别名 endo-IWR 1

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID