IWR-1-endo

For research use only. Not for use in humans.

目录号:S7086 别名: endo-IWR 1

IWR-1-endo Chemical Structure

CAS No. 1127442-82-3

IWR-1-endo (endo-IWR 1)是一种Wnt通路抑制剂,在表达 Wnt3A 的 L-细胞中IC50为180 nM,诱导Axin2蛋白水平,并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 975.58 现货
RMB 900.38 现货
RMB 2050.64 现货
RMB 5151.51 现货
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客户使用Selleck生产的IWR-1-endo发表文献69篇:

产品安全说明书

Wnt/beta-catenin抑制剂选择性比较

生物活性

产品描述 IWR-1-endo (endo-IWR 1)是一种Wnt通路抑制剂,在表达 Wnt3A 的 L-细胞中IC50为180 nM,诱导Axin2蛋白水平,并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。
靶点
Wnt [1]
(L-cells expressing Wnt3A)
180 nM
体外研究

IWR-1 和XAV939作为Wnt通路的可逆抑制剂,在体内外具有相似的药理作用,IWR-1通过与Axin相互作用而发挥效果,而XAV939直接与TNKS结合。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21 (DE3) M13zSGZ2dmO2aX;uJIF{e2G7 M1XCRVkxKG2rboO= NX:yfnpJSWO2aY\peJkhd2ZiTj30[ZJucW63czDo[ZhiUGm|LYTh[4dm\CCqdX3hckBVVlONMjDlfJBz\XO|ZXSgbY4hTXOlaHXybYNpcWFiY3;sbUBDVDJzIDjESVMqKGOnbHzzJJV{cW6pIHLpc5RqdnmuYYTl[EBPSURtIHHzJJN2[nO2cnH0[UBi\nSncjC5NEBucW6|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqeyxiRVO1NEA:KDBwMjFOwG0v MnTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{M{OzNlAoRjJ{MkOzN|IxRC:jPh?=
SW480 NHT6WJdHfW6ldHnvckBie3OjeR?= MWmyOEBpenN? MWjJcohq[mm2aX;uJI9nKHSjbnv5doF{\SCrbjDoeY1idiCVV{S4NEBk\WyuczDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25ib3[gZZhqdjJiYX\0[ZIhOjRiaILzJIJ6KEixZXPod5Qh\HmnLXLhd4VlKG2ndHjv[EwhTUN3MDC9JFIvPSEQvF2u NGfNNpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewNVUyPyd-MkO3NFE2OTd:L3G+
HEK293T NFPkbGZHfW6ldHnvckBie3OjeR?= MojZTY5pcWKrdHnvckBw\iCkZYThMYNie2Wrbj3k[ZBmdmSnboSgZ4Fvd26rY3HsJHdvfDNicHH0bJdigSCrbjDoeY1idiCKRVuyPVNVKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OCB;IECuNFI3KM7:TT6= MmflQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzOUG1OVcoRjJ{MUmxOVU4RC:jPh?=
SW480 MmG5SpVv[3Srb36gZZN{[Xl? MX60NEB1dyB2ODDodpM> NF3MVoJKdmirYnn0bY9vKG:oIIThcot6emG|ZTDpckBpfW2jbjDTW|Q5OCClZXzsd{Bie3Onc4Pl[EBieyCmZXfyZYRifGmxbjDv[kBj\XSjIHPheIVvcW5iYX\0[ZIhPDBidH:gOFghcHK|LDDJR|UxKD1iMD6yOUDPxE1w NUDEO2xuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3NFE2OTdpPkKzO|AyPTF5PD;hQi=>
L-Wnt-STF NUTnTHEzTnWwY4Tpc44h[XO|YYm= Mlr2NlQhcHK| MWTJcohq[mm2aX;uJI9nKFSQS2OtNkBqdiCvb4Xz[UBNNVewdD3TWGYh[2WubIOgZZN{\XO|ZXSgZZMh\Gm|coXweIlwdiCxZjDXcpQhe2mpbnHsbY5oKGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVAhRSByLkC1OkDPxE1w MnPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3Mke3PVIoRjJ2NUK3O|kzRC:jPh?=
L-Wnt-STF NFO4XIxHfW6ldHnvckBie3OjeR?= MUmyOEBpenN? NVflPHF{UW6qaXLpeIlwdiCxZjDUUmtUNTFiaX6gcY92e2ViTD3XcpQuW1SIIHPlcIx{KGG|c3Xzd4VlKGG|IHTpd5J2eHSrb36gc4YhX262IIPp[45idGmwZzDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyIE2gNE4yOzFizszNMi=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{N{e5Nkc,OjR3Mke3PVI9N2F-
HT29 MWDGeY5kfGmxbjDhd5NigQ>? M1nWclI1KGi{cx?= MUXJcohq[mm2aX;uJI9nKFewdDDzbYdv[WyrbnegbY4hcHWvYX6gTHQzQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIJmfGFvY3H0[Y5qdi2vZXTpZZRm\CCWY3[vUIVnKHS{YX7zZ5JqeHSrb37hcEBi[3Srdnn0fUBi\nSncjCyOEBpenNiYomg[JVidCCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmgdoVt[XSrdnWgeI8h[2:wdILvcEwhUUN3MDC9JFI1NjRizszNMi=> NXvEVppkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVA1QDlpPkK0PVUxPDh7PD;hQi=>
DLD1 MWHGeY5kfGmxbjDhd5NigQ>? NEOwbpMyOCC3TR?= MlPJTY5lfWO2aX;uJI9nKEG6aX6yJIlvKGi3bXHuJGRNTDFiY3XscJMhd3[ncnX4dJJme3OrbnegTXdTNUmVIHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFewdDDwZZRpf2G7IHHjeIl3cXS7IHH0JFExKHWPIHL5JHNVTiC{ZYDvdpRmeiCjc4PhfUBu\XSqb3S= NF\pRpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOVE2Pid-MUmxNlUyPTZ:L3G+
HEK293 NW[2ZnEzTnWwY4Tpc44h[XO|YYm= NH\NWpRFcXOybHHj[Y1mdnRib3[gTXdTNVCEIH\yc40hSXirbkKgbY4hUEWNMkmzJINmdGy|IHL5JHdme3Sncn6gZoxwfCCvZYToc4Q> MoD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMkWxOVYoRjF7MUK1NVU3RC:jPh?=
DLD1 MVHGeY5kfGmxbjDhd5NigQ>? M1rBWWlvcGmkaYTpc44hd2ZiQYjpclIheHKxdHXpckBl\We{YXTheIlwdiCrbjDoeY1idiCGTFSxJINmdGy|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NIXMfXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOVE2Pid-MUmxNlUyPTZ:L3G+
DLD1 NXXFSXcxTnWwY4Tpc44h[XO|YYm= NV;IVmlTUW6mdXP0bY9vKG:oIFH4bY4zKGGlY4XteYxifGmxbjDpckBpfW2jbjDEUGQyKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIGTodlQyKHCqb4PwbI9zgWyjdHXkJIJmfGFvY3Hz[YlvKGyndnXsd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= NYfxWmpCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxNlUyPTZpPkG5NVI2OTV4PD;hQi=>
DLD1 NHvRNWFHfW6ldHnvckBie3OjeR?= MlLtTY5lfWO2aX;uJI9nKEG6aX6yJIFk[3WvdXzheIlwdiCrbjDoeY1idiCGTFSxJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFOnckO3JJBpd3OyaH;yfYxifGWmIHLleIEu[2G|ZXnuJIxmfmWuczDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF{NUG1Okc,OTlzMkWxOVY9N2F-
DLD1 NYXoPIV1TnWwY4Tpc44h[XO|YYm= MoKxSIVkemWjc3WgbY4h[mW2YT3jZZNmcW5iYXPjeY12dGG2aX;uJIlvKGi3bXHuJGRNTDFiY3XscJMh\XiycnXzd4lv\yCrbjDBVGMhdXW2YX70 M1iwSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK1NVU3Lz5zOUGyOVE2PjxxYU6=
DLD1 NF2wSXZHfW6ldHnvckBie3OjeR?= NG\2UZczKGi{cx?= M1XESWlv\HWldHnvckBw\iCDeHnuNkB{fGGkaXzpfoF1cW:wIHnuJIh2dWGwIFTMSFEh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4VlKHS{YX7zZ5JqeHSrb36gc4YhSXirbkKgZYZ1\XJiMjDodpMh[nliUmStVGNTKG2ndHjv[C=> M3q5c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK1NVU3Lz5zOUGyOVE2PjxxYU6=
DLD1 NHfHd3JHfW6ldHnvckBie3OjeR?= MnfVTY5lfWO2aX;uJI9nKEG6aX6yJIFk[3WvdXzheIlwdiCrbjDoeY1idiCGTFSxJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKG[{ZXWgZoV1[S2lYYPlbY4hdGW4ZXzzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NHTqOpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOVE2Pid-MUmxNlUyPTZ:L3G+
DLD1 NGDnd|hHfW6ldHnvckBie3OjeR?= MmGwTY5lfWO2aX;uJI9nKEG6aX6yJJN1[WKrbHn6ZZRqd25iaX6gbJVu[W5iRFzENUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGfueE9j\XSjLXPhd4VqdiCyYYToe4F6 MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF{NUG1Okc,OTlzMkWxOVY9N2F-
DLD1 NHPZTZZHfW6ldHnvckBie3OjeR?= MkHoTY5lfWO2aX;uJI9nKEG6aX6yJIFk[3WvdXzheIlwdiCrbjDoeY1idiCGTFSxJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFOnckOzJJBpd3OyaH;yfYxifGWmIHLleIEu[2G|ZXnuJIxmfmWuczDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? NH;U[ZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOVE2Pid-MUmxNlUyPTZ:L3G+
DLD1 NEH5bnpHfW6ldHnvckBie3OjeR?= NHHiVFVKdmS3Y4Tpc44hd2ZiQYjpclIh[WOldX31cIF1cW:wIHnuJIh2dWGwIFTMSFEh[2WubIOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| M2HQVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK1NVU3Lz5zOUGyOVE2PjxxYU6=
DLD1 M4fyS2Z2dmO2aX;uJIF{e2G7 MWexJJRwKDJyIIXN NV7nUllTOjRiaILz NX;zO3pIUW6qaXLpeIlwdiCxZjD0ZY5sgXKjc3WgbY4hcHWvYX6gSGxFOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHRETi2mZYDlcoRmdnRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGG2IEGgeI8hOjBidV2gZYZ1\XJiMkSgbJJ{KGK7IHT1ZYwhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 NE\ucZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyO|c6Oid-MkS1Nlc4QTJ:L3G+
DLD1 MXTDfZRwfG:6aXPpeJkh[XO|YYm= M4rlW|EhfG9iMkCgeW0> MXexNEBl[Xm| M{S4VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRNTDFiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYYSgNUB1dyB{MDD1UUBu\WG|dYLl[EBwdiCmYYmgNVAh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoc> NIT6Zmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyO|c6Oid-MkS1Nlc4QTJ:L3G+
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
E-cadherin / N-cadherin / Snail / Vimentin; 

PubMed: 26450645     


Western blot analyses showing protein expression patterns of the EMT markers according to IWR-1 dose and exposure time. β-Actin was used as a loading control.

p-Akt / Akt; 

PubMed: 26450645     


Western blot analysis showing that IWR-1 decreased the phosphorylation of Akt in a concentration- and time-dependent manner, respectively.

Survivin; 

PubMed: 26450645     


Western blot analysis showing that IWR-1 decreased the survivin expression in a concentration- and time-dependent manner, respectively.

26450645

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 21 mg/mL (51.28 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 409.44
化学式

C25H19N3O3

CAS号 1127442-82-3
储存条件 粉状
溶于溶剂
别名 endo-IWR 1

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID