Salinomycin (from Streptomyces albus)

For research use only. Not for use in humans.

目录号:S8129 别名: Coxistac, Bio-cox, Procoxacin 中文名称:盐霉素(来自白色链霉菌)

Salinomycin (from Streptomyces albus) Chemical Structure

CAS No. 53003-10-4

Salinomycin (Coxistac, Bio-cox, Procoxacin), 曾经被用作抗球虫药,具有抗癌和抗肿瘤干细胞的效果。

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RMB 1040.98 现货
RMB 3743.72 现货
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客户使用Selleck生产的Salinomycin (from Streptomyces albus)发表文献13篇:

客户使用该产品的2个实验数据:

  • The salinomycin inhibited the growth of CNE-2 in time- and dose-dependent manner. SAL salinomycin

    Tumour Biol, 2016, 305-11. Salinomycin (from Streptomyces albus) purchased from Selleck.

  • Drug sensitivity of KPC tumor cell subpopulations. CD133, Aldefluor, and Sca-1-positive or -negative cells or unsorted KPC cells were cultured in the presence of increasing concentrations of salinomycin. After 72 hours, cell viability was assessed using CellTiter Glo reagent, and percent viability was normalized to vehicle-treated controls. Pair-wise multiple comparisons were performed with one-way ANOVA with Bonferroni adjustment. P values < 0.05 were considered statistically significant.

    Tumor and Stem Cell Biology, 2015, 75(21):4582-4592.. Salinomycin (from Streptomyces albus) purchased from Selleck.

质量管理及产品安全说明书

Wnt/beta-catenin抑制剂选择性比较

生物活性

产品描述 Salinomycin (Coxistac, Bio-cox, Procoxacin), 曾经被用作抗球虫药,具有抗癌和抗肿瘤干细胞的效果。
靶点
Wnt/β-catenin [1]
()
体外研究

Salinomycin是一种从Streptomyces albus中分离的聚醚类离子载体型抗生素,通过干扰药物转运体ABC(ATP结合位点)、Wnt/β-catenin及其他CSC信号通路,在多种不同的人类癌症中,杀死癌症干细胞。Salinomycin对Gram阳性的细菌具有抗菌活性,除此之外,salinomycin在不同的生物膜中发挥作用,包括胞膜、线粒体膜,其作为单价阳离子载体,对碱金属离子有较强的选择性,对K+有偏好性,因此能促进线粒体和胞质中K+外流、并抑制氧化磷酸化。Salinomycin能够诱导不同起源的人类癌细胞系的大量凋亡[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL60 cells NXnjVWtrWHKxbHnm[ZJifGmxbjDhd5NigQ>? M{Pr[VczKGh? MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkK5JO69VQ>? NVK3b4l7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
MV4-11 cells M1y2PHBzd2yrZnXyZZRqd25iYYPzZZk> MYi3NkBp NXy3[mFDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO|IhcHK|LDDJR|UxRTBwM{Og{txO MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4M{G5O{c,OjZzNkOxPVc9N2F-
LoVo cells NWnhOIg2WHKxbHnm[ZJifGmxbjDhd5NigQ>? NYjvc3U3PzJiaB?= NGPQfm1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzvWo8h[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCvZYToc4QtKEmFNUC9NE4{PiEQvF2= NHTEPYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
VCaP cells MV\Qdo9tcW[ncnH0bY9vKGG|c3H5 MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKF[FYWCgZ4VtdHNuIFXDOVA:OC5|ODFOwG0> MmXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkO0NFAoRjJ|ME[zOFAxRC:jPh?=
LS180 cells NULidnVZWHKxbHnm[ZJifGmxbjDhd5NigQ>? M4LYc|czKGh? MkX4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOU{G4NEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3ME2wMlYyKM7:TR?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
HT-29 cells MlzkVJJwdGmoZYLheIlwdiCjc4PhfS=> NF3KeJY4OiCq M{H6bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCvZYToc4QtKEmFNUC9NU4xOyEQvF2= NGDab2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
SW707 cells Mn\WVJJwdGmoZYLheIlwdiCjc4PhfS=> MXy3NkBp NEfpUW9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXO|A4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBUWkJibXX0bI9lNCCLQ{WwQVEvPzNizszN NUH2e5NxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
HL60/Vinc cells MkOyR5l1d3SxeHnjbZR6KGG|c3H5 MXO3NkBp MXXDfZRwfG:6aXPpeJkh[WejaX7zeEB3cW6lcnnzeIlv\S2{ZYPpd5RidnRiaIXtZY4hUEx4MD;WbY5kKGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1|LkS0JO69VQ>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB5OUWyN{c,OjNyN{m1NlM9N2F-
BALB/3T3 cells MUTDfZRwfG:6aXPpeJkh[XO|YYm= MV:3NkBp MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRWxDNzOWMzDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlgvODhizszN MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB5OUWyN{c,OjNyN{m1NlM9N2F-
VCaP NGKydYRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NULFbWdCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDWR4FRKGOnbHzzMEBGSzVyIE2gNE4{QCEQvF2u M2fu[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[zOFAxLz5{M{C2N|QxODxxYU6=
HL60 NWP1fppTS3m2b4TvfIlkcXS7IHHzd4F6 M4DPSlczKGi{cx?= NYD5[Zl6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjR2IN88UU4> NF;vTo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C3PVUzOyd-MkOwO|k2OjN:L3G+
LoVo NVjndZhRS3m2b4TvfIlkcXS7IHHzd4F6 Mnz0O|IhcHK| NFjjNFlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNd1[xIHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvOTFizszNMi=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB5OUWyN{c,OjNyN{m1NlM9N2F-
HL60/Vinc NHnmc5NEgXSxdH;4bYNqfHliYYPzZZk> MV:3NkBpenN? MmK0R5l1d3SxeHnjbZR6KGGpYXnud5QhfmmwY4Lpd5RqdmVvcnXzbZN1[W62IHj1cYFvKEiONkCvWolv[yClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlQ1KM7:TT6= NUHibG9mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwO|k2OjNpPkKzNFc6PTJ|PD;hQi=>
LoVo/DX MmfrR5l1d3SxeHnjbZR6KGG|c3H5 NHzINlA4OiCqcoO= NG\oZ3dEgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgbJVu[W5iTH;Wc{9FYCClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC2MlI{KM7:TT6= Mn;UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyN{m1NlMoRjJ|MEe5OVI{RC:jPh?=
BALB/3T3 NWnXfpVzS3m2b4TvfIlkcXS7IHHzd4F6 NInKOJk4OiCqcoO= NYjI[YFzS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkGOQj:zWFMh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuNFgh|ryPLh?= M1WwflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEe5OVI{Lz5{M{C3PVUzOzxxYU6=
LoVo/DX NHnZfYJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyxVn:vSHgh[2WubIOsJGlEPTBiPTCxJO69VS5? NWT3XIhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N|EyQTBpPkK0OlMyOTlyPD;hQi=>
HL60 M2nBeGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MmD6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|LDDJR|UxKD1iMT6yJO69VS5? NYrOS5NwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N|EyQTBpPkK0OlMyOTlyPD;hQi=>
LoVo MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyxVn:gZ4VtdHNuIFnDOVAhRSBzLkWg{txONg>? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ|MUG5NEc,OjR4M{GxPVA9N2F-
HL60/Vinc MkjIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmLvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wM3ZqdmNiY3XscJMtKEmFNUCgQUA1NjdizszNMi=> NX;0e3JZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N|EyQTBpPkK0OlMyOTlyPD;hQi=>
BALB/3T3 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NETTeJdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBud3W|ZTDCRWxDNzOWMzDj[YxteyxiSVO1NEA:KDJ3Lkig{txONg>? NXjrUFdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N|EyQTBpPkK0OlMyOTlyPD;hQi=>
HL60 NX3xfoQ5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIn2fmk4OiCqcoO= MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNlkh|ryPLh?= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
LoVo NUTPNJNXSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVO3NkBpenN? M{TmSmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFAvOzZizszNMi=> MoXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
LS180 M2TrdGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3fjT|czKGi{cx?= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyVMUiwJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIhdWW2aH;kMEBKSzVyIE2gNE43OSEQvF2u M2Tv[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
LoVo/DX M37PWWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnrnO|IhcHK| M2K0VmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JGxwXm9xRGigZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBu\XSqb3SsJGlEPTBiPTCwMlc3KM7:TT6= NFXm[3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
HT-29 M4\WW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml;qO|IhcHK| MknaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFEvODNizszNMi=> NGnNWY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
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HL60/Vinc M3qzPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MknyO|IhcHK| MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKH[rbnPybZN1cW6nLYLld4l{fGGwdDDIUFYxN1[rbnOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuNFkh|ryPLh?= MoL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
BALB/3T3 NIfxNndCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXS3NkBpenN? M17MUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlHMRk8{XDNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KFOUQjDt[ZRpd2RuIFnDOVAhRSB7LkOzJO69VS5? M4P5NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
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... Click to View More Cell Line Experimental Data

体内研究 Salinomycin能够有效地消除癌症干细胞,从而诱导预处理过的和具有药物抗性的癌症部分临床回归。它还是阳性的离子型和变时型试剂,其处理过后能加大心输出量、左心室收缩压、提高心率、平均动脉压、灌装动脉血管舒张以及血流量、血浆儿茶酚胺的浓度。这些实验结果都是以口服、吸入式注射150 μg/kg salinomycin的交交犬为模型进行的研究。然而,在哺乳动物中如马、猫、猪和羊驼,salinomycin被报导在偶然的口服或吸入摄入的情况下,具有相当大的毒性作用。风险评估数据表明,人类可接受的salinomycin每日可摄入量为5 μg/kg,超过500 μg/kg的每日摄入量会对狗产生神经毒性,如髓鞘损失、轴索变性。静脉注射200-250 μg/kg的salinomycin三周(隔天注射)会导致肿瘤转移的部分消退、仅有非常小的急性、长期副作用,使用传统的化疗药物治疗途径,则没有严重的急性长期副作用[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[2]

- 合并
  • Cell lines: 结肠癌细胞(SW480, SW620, RKO)、乳腺癌细胞系(MCF-7, T47D, MDA-MB-453).
  • Concentrations: 1, 2.5, 5, 10 μM
  • Incubation Time: 26 h
  • Method:

    将细胞以1500/孔(SW480或SW620)或4000/孔(其他细胞系)的密度铺于平底96孔板。16小时后,用salinomycin对细胞进行处理22小时,然后每孔加入溶于PBS中的5 mg/ml MTT,4小时,加入triplex solution裂解细胞。读取562 nm出的吸光值。


    (Only for Reference)
动物实验:

[3]

- 合并
  • Animal Models: NOD/SCID小鼠
  • Dosages: 5 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (133.15 mM)
Water Insoluble
Ethanol '79 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 751.00
化学式

C42H70O11

CAS号 53003-10-4
储存条件 粉状
溶于溶剂
别名 Coxistac, Bio-cox, Procoxacin

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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操作手册

如果有其他问题,请给我们留言。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID