Wnt/beta-catenin 选择性抑制剂 | 激活剂 | 激动剂 | 拮抗剂 | 调节剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S3842 Isoquercitrin

Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.

Selective
S8129 Salinomycin (from Streptomyces albus)

Salinomycin, 曾经被用作抗球虫药,具有抗癌和抗肿瘤干细胞的效果。

Selective
S8178 Wnt agonist 1

Wnt agonist 1是具有细胞透性的Wnt信号通路激活剂,诱导依赖于β-catenin-和TCF-的转录活性,EC50为0.7 μM。

Selective
S3630 Methyl Vanillate

Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.

Selective
S8320 SKL2001

SKL2001是一种新型的Wnt/β-catenin信号通路的激动剂,破坏Axin/β-catenin的相互作用。

Selective
S8647 iCRT3

iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.

Selective Wnt/β-catenin, IC50: 8.2 nM
S8429 PNU-74654

PNU-75654通过抑制β-catenin和Tcf4的相互作用(Kd=450 nM),破坏Wnt signaling pathway

Selective Wnt/β-catenin, Kd: 450 nM
S8327 KYA1797K

KYA1797K是一种有效的、高度选择性的Wnt/β-catenin抑制剂,在TOPflash实验中,IC50为0.75 μM。

Selective Wnt/β-catenin, IC50: 0.75 μM
S0458 KY1220

KY1220 destabilises both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.

Selective Wnt/β-catenin, IC50: 2.1 μM
S2788 Capmatinib (INCB28060)

Capmatinib (INCB28060)是一种新型的,ATP竞争性c-MET抑制剂,无细胞试验中IC50为0.13 nM,对RONβ,EGFR和HER-3无活性。Phase 1。

Selective
S7484 FH535

FH535是一种Wnt/β-catenin信号传导抑制剂,同时也是PPARγPPARδ的双重拮抗剂。

Selective
S9416 Triptonide

Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.

Selective
S3223 L-Quebrachitol

L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.

Selective