Calcium Channel

信号通路图

研究领域

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S1356 Levetiracetam 34 mg/mL 34 mg/mL 34 mg/mL
S1813 Amlodipine Besylate <1 mg/mL 113 mg/mL 14 mg/mL
S1293 Cilnidipine <1 mg/mL 99 mg/mL 15 mg/mL
S1811 Amiloride HCl 6 mg/mL 53 mg/mL 5 mg/mL
S1425 Ranolazine 2HCl 100 mg/mL 100 mg/mL <1 mg/mL
S4977 Efonidipine -1 mg/mL 100 mg/mL 40 mg/mL
S4787 Methyl syringate -1 mg/mL 42 mg/mL -1 mg/mL
S3867 (E)-Cardamoni -1 mg/mL 54 mg/mL -1 mg/mL
S3883 Protopine -1 mg/mL 30 mg/mL -1 mg/mL
S3809 Imperatorin -1 mg/mL 54 mg/mL -1 mg/mL
S3845 Panaxadiol <1 mg/mL <1 mg/mL 22 mg/mL
S3942 Cardamonin <1 mg/mL 54 mg/mL 54 mg/mL
S3682 Ethyl 3-Aminobenzoate methanesulfonate 52 mg/mL 52 mg/mL 52 mg/mL
S3674 Levamlodipine 81 mg/mL 81 mg/mL 81 mg/mL
S3700 DHBP dibromide 100 mg/mL 100 mg/mL 100 mg/mL
S4202 Verapamil HCl 50 mg/mL 98 mg/mL 12 mg/mL
S2482 Manidipine 2HCl <1 mg/mL 21 mg/mL <1 mg/mL
S1799 Ranolazine <1 mg/mL 86 mg/mL 20 mg/mL
S1662 Isradipine <1 mg/mL 74 mg/mL 74 mg/mL
S1905 Amlodipine <1 mg/mL 82 mg/mL 82 mg/mL
S1885 Felodipine <1 mg/mL 77 mg/mL 72 mg/mL
S2481 Manidipine <1 mg/mL 122 mg/mL 3 mg/mL
S1748 Nisoldipine <1 mg/mL 77 mg/mL 60 mg/mL
S1747 Nimodipine <1 mg/mL 84 mg/mL 84 mg/mL
S2535 Econazole nitrate <1 mg/mL 89 mg/mL 5 mg/mL
S2721 Nilvadipine <1 mg/mL 77 mg/mL 33 mg/mL
S1994 Lacidipine <1 mg/mL 91 mg/mL 22 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S2446 Levosimendan <1 mg/mL 56 mg/mL <1 mg/mL
S4181 Nicardipine HCl <1 mg/mL 100 mg/mL <1 mg/mL
S1808 Nifedipine <1 mg/mL 69 mg/mL 15 mg/mL
S2080 Clevidipine Butyrate <1 mg/mL 91 mg/mL 3 mg/mL
S2017 Benidipine HCl <1 mg/mL 8 mg/mL <1 mg/mL
S2918 HC-030031 <1 mg/mL 32 mg/mL <1 mg/mL
S2030 Flunarizine 2HCl <1 mg/mL 5 mg/mL 3 mg/mL
S2491 Nitrendipine <1 mg/mL 72 mg/mL <1 mg/mL
S2050 Strontium Ranelate <1 mg/mL <1 mg/mL <1 mg/mL
S3053 Azelnidipine <1 mg/mL 117 mg/mL 7 mg/mL
S2573 Tetracaine HCl 60 mg/mL 60 mg/mL 30 mg/mL
S1911 Disodium Cromoglycate 2 mg/mL <1 mg/mL <1 mg/mL
S1865 Diltiazem HCl 90 mg/mL 90 mg/mL 4 mg/mL
S7999 SKF96365 80 mg/mL 80 mg/mL 80 mg/mL
S3045 Cinepazide maleate 107 mg/mL 107 mg/mL <1 mg/mL
S8380 YM-58483 (BTP2) <1 mg/mL 84 mg/mL 84 mg/mL
S8073 Optovin <1 mg/mL 63 mg/mL <1 mg/mL
S4626 Ethosuximide 28 mg/mL 28 mg/mL 28 mg/mL
S4597 Lercanidipine hydrochloride <1 mg/mL 66 mg/mL 1 mg/mL
S2403 Tetrandrine <1 mg/mL 1 mg/mL 2 mg/mL
S4084 Lomerizine 2HCl <1 mg/mL 100 mg/mL 52 mg/mL
S4648 Dantrolene sodium hemiheptahydrate <1 mg/mL 14 mg/mL <1 mg/mL
S7924 Bay K 8644 <1 mg/mL 71 mg/mL 71 mg/mL
S2415 Astragaloside A <1 mg/mL 100 mg/mL <1 mg/mL
S4209 Chlorocresol <1 mg/mL 29 mg/mL 29 mg/mL
S4727 Cinnarizine <1 mg/mL 73 mg/mL <1 mg/mL
产品目录 产品描述 文献引用 实验数据
S1356

Levetiracetam

Levetiracetam是一种抗癫痫化合物。

S1813

Amlodipine Besylate

Amlodipine Besylate是一种长效的钙离子通道抑制剂,IC50为1.9 nM。

S1293

Cilnidipine

Cilnidipine是一种L型和N型钙离子通道抑制剂,用来治疗高血压。

S1811

Amiloride HCl

Amiloride是一种选择性的T-type calcium channel阻滞剂,epithelial sodium channel(ENaC)阻滞剂,urokinase plasminogen activator (uPA)抑制剂,Ki=7 μM。

S1425

Ranolazine 2HCl

Ranolazine 2HCl是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。

S4977New

Efonidipine

Efonidipine是一种L型和T型钙离子通道/b>阻滞剂,可引起血管舒张和心脏自律性降低。它还能抑制醛固酮从肾上腺分泌。

S4787New

Methyl syringate

Methyl syringate, a plant phenolic compound, is a specific and selective TRPA1 agonist.

S8691New

ML204

ML204是新型的、有效的、选择性的TRPC4抑制剂。在胞内钙离子荧光分析试验中,IC50为1 μM。在全细胞电压钳实验中,IC50约为3 μM。ML204对TRPC通道的选择性远高于对其他TRP通道和非TRP通道的选择性。

S3867New

(E)-Cardamoni

Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.

S3883New

Protopine

Protopine, an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.

S3809New

Imperatorin

Imperatorin, a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.

S3845New

Panaxadiol

Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

S3942New

Cardamonin

Cardamonin天然存在于良姜属物种的果实中,具有抗炎和抗肿瘤活性。它是一种新型的hTRPA1离子通道拮抗剂,IC50为454 nM,而不与TRPV1和TRPV4相互作用。

S3682New

Ethyl 3-Aminobenzoate methanesulfonate

Ethyl 3-Aminobenzoate可通过voltage-dependent Na+-channels阻止动作电位的产生,常用于鱼类的麻醉、镇静和安乐死。

S3674New

Levamlodipine

Levamlodipine is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.

S3700New

DHBP dibromide

DHBP,一种用于电致色记忆显示剂的紫罗碱,抑制由2 mM咖啡因和2 μg/ml多熔素诱导的钙释放,IC50分别为5 μg/ml和4 μg/ml。

S4202

Verapamil HCl

Verapamil HCl是L-型钙通道抑制剂,是第四类抗心律失常的药剂。

S2482

Manidipine 2HCl

Manidipine 2HCl是Manidipine的盐酸盐形式,是钙通道阻断剂,IC50为2.6 nM,临床上常用于抗高血压。Phase 4。

S1799

Ranolazine

Ranolazine 2HCl是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。

S1662

Isradipine

Isradipine是一种高效选择性的L型压力控式钙离子通道抑制剂,用于治疗高血压。

S1905

Amlodipine

Amlodipine 是一种长效的钙离子通道抑制剂,用于降低血压缓解胸部疼痛。

S1885

Felodipine

Felodipine 是一种选择性L型Ca2+通道阻断剂,IC50为0.15 nM。

S2481

Manidipine

Manidipine是一种二氢吡啶类钙拮抗剂,用于治疗高血压。

S1748

Nisoldipine

Nisoldipine是特定L型CaV1.2钙通道阻断剂,IC50为10 nM。

S1747

Nimodipine

Nimodipine是一种二氢吡啶衍生物,是钙离子通道抑制剂Nifedipine的类似物,具有降压活性。Nimodipine能减少细胞内游离Ca2+,Beclin-1及细胞自噬。

S2535

Econazole nitrate

Econazole nitrate 是一种咪唑类抗真菌药物。

S2721

Nilvadipine

Nilvadipine是一种强效钙通道阻滞剂,IC50为0.03 nM。

S1994

Lacidipine

Lacidipine 是一种L-型钙离子通道抑制剂。

S2114

Dronedarone HCl

Dronedarone HCl 用于治疗阵发性和持续性房颤或房扑的患者。

S2446

Levosimendan

Levosimendan 是一种钙增敏剂,通过与cardiac troponin C (cTnC)结合而发挥作用,这种作用具有钙依赖性。

S4181

Nicardipine HCl

Nicardipine HCl是二氢吡啶的钙通道抑制剂,具有显著的血管扩张作用。

S1808

Nifedipine

Nifedipine 是一种二氢吡啶类钙离子通道阻滞剂,是有效的血管扩张剂,具有钙拮抗作用。

S2080

Clevidipine Butyrate

Clevidipine Butyrate是一种二氢吡啶类钙离子通道抑制剂,用于降血压。

S2017

Benidipine HCl

Benidipine HCl是Benidipine的盐酸盐形式,是一种二氢吡啶类的钙离子通道抑制剂。 

S2918

HC-030031

HC-030031是一种选择性的TRPA1通道阻断剂,可以拮抗AITC和formalin引起的钙流入,IC50分别为6.2μM和5.3μM。

S2030

Flunarizine 2HCl

Flunarizine 2HCl是一种二氢盐酸盐,抑制钙离子通道,Ki为68 nM。

S2491

Nitrendipine

Nitrendipine是一种二氢吡啶类钙离子通道抑制剂,IC50为95 nM。

S2050

Strontium Ranelate

Strontium Ranelate 是Ranelic acid的锶(II)盐,用于(-)-Desmethoxyverapamil结合到钙离子通道,IC50为0.5 mM。

S3053

Azelnidipine

Azelnidipine是一种二氢吡啶类钙通道阻断剂。

S2573

Tetracaine HCl

Tetracaine HCl 是Tetracaine的盐酸盐形式,是一种有效的局部麻醉剂和通道功能变构酶抑制剂。

S1911

Disodium Cromoglycate

Disodium Cromoglycate是一种抗过敏药,IC50为39 μg/mL。

S1865

Diltiazem HCl

Diltiazem HCl 是一种Benzothiazepine衍生物,具有舒张血管的作用,由于其抑制钙离子在膜的功能。

S7999

SKF96365

SKF96365,最初认为是钙通道阻滞剂,目前作为TRPC通道阻滞剂,被广泛用于医疗诊断。

S3045

Cinepazide maleate

Cinepazide maleate是cinepazide的马来酸盐形式,而cinepazide是一种血管舒张药。

S8380

YM-58483 (BTP2)

YM-58483/BTP2是钙池调控钙离子进入(SOCE)的阻滞剂,参与调解不可兴奋细胞如淋巴细胞的激活。

S8073

Optovin

Optovin是一个可逆的光活化的TRPA1活化剂。

S4626

Ethosuximide

Ethosuximide是一种琥珀酰亚胺类的抗痉挛试剂,主要用于失神发作。是钙离子通道阻滞剂。

S4597

Lercanidipine hydrochloride

Lercanidipine是二氢吡啶类的钙离子通道抑制剂。

S2403

Tetrandrine

Tetrandrine是来源于千金藤根部的一种双苯基异喹啉,一种钙离子通道抑制剂。

S4084

Lomerizine 2HCl

Lomerizine dihydrochloride是一种相对较新的L-和T-型钙通道阻滞剂,用于治疗偏头痛。

S4648

Dantrolene sodium hemiheptahydrate

Dantrolene sodium hemiheptahydrate是一种骨骼肌松弛药,通过干扰肌纤维中的兴奋-收缩偶联起作用。

S7924

Bay K 8644

Bay K 6244是一种高选择性的L型钙离子通道激动剂,EC50为17.3 nM。

S2415

Astragaloside A

Astragaloside A是从黄芪中分离的一种纯化的皂苷,广泛应用于治疗心血管疾病。

S4209

Chlorocresol

Chlorocresol 是ryanodine receptor激活剂。

S4727

Cinnarizine

Cinnarizine是piperazine的药物衍生物,是抗组胺剂钙离子通道阻滞剂。