GABA Receptor
信号通路图
研究领域
抑制剂选择性比较
GABA Receptor产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂，也会抑制HDAC2的蛋白酶体降解，用于治疗癫痫和躁郁症，并预防偏头痛。 |
Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
| S3018 |
Niflumic acidNiflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。 |
||
| S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride是tiagabine的盐酸盐形式，是哌啶甲酸衍生物，具有抗惊厥作用，它是选择性的GABA重吸收抑制剂。 |
||
| S4675 |
TiagabineTiagabine是一种抗惊厥的药物，是GABA重吸收的抑制剂。 |
||
| S1969 |
NefiracetamNefiracetam作用于Ro 5-4864引起的抽搐，是GABAergic，胆碱及单胺类的神经系统增强剂。Phase 2。 |
||
| S1332 |
FlumazenilFlumazenil是一种苯二氮卓类拮抗剂。 |
||
| S6094New |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。 |
||
| S9249New |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
| S9176New |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
||
| s9065New |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
| S7071 |
(+)-Bicuculline(+)-Bicuculline是一种竞争性GABAA受体拮抗剂，IC50为2 μM，也抑制Ca(2+)激活的钾离子通道。 |
-Bicuculline-S707101X0320161109.gif)
-Bicuculline-S707101X0320161109.gif)
Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
|
| S2026 |
Ginkgolide AGinkgolide A是银杏的提取物，是γ-氨基丁酸(GABA)拮抗剂，Ki为14.5 μM。 |
||
| S4587 |
PentylenetetrazolPentylenetetrazol是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。 |
||
| S4197 |
BemegrideBemegride是一种中枢神经系统兴奋剂，及Barbiturate中毒的解毒剂。 |
||
| S5049 |
ThiocolchicosideThiocolchicoside是一种天然存在的配糖体，来源于嘉兰百合的花种中，具有抗炎和止痛活性，同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
||
| S1338 |
Gabapentin HClGabapentin HCl是一种GABA类似物。 |
||
| S1329 |
EtomidateEtomidate是一种GABAA受体激动剂， 用作短效的麻醉剂或者安定剂。 |
||
| S2133 |
GabapentinGabapentin 是一种GABA类似物，用于治疗癫痫及神经痛。 |
||
| S5612New |
Isonipecotic acidIsonipecotic acid是杂环化合物，主要是作为GABAA receptor部分激动剂发挥作用。 |
||
| S3072 |
(R)-baclofen(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。 |
||
| S4574 |
PiperazinePiperazine是GABA受体的激动剂，是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。 |
||
| S4840 |
BaclofenBaclofen是GABA衍生物，被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors，尤其是GABAB受体。 |
||
| S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone是一种天然类黄酮，与GABAA receptors结合，是GABAA receptors的部分激动剂。 |
||
| S4892 |
PhenibutPhenibut，作为GABA类似物，是靶向中枢神经系统的镇静剂，具有抗焦虑和镇静效果。 |
||
| S2269 |
BaicalinBaicalin 是一种脯氨酰肽链内切酶抑制剂，影响GABA受体。 |
||
| S3786 |
GlabridinGlabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
||
| S2399 |
DihydromyricetinDihydromyricetin 是具有良好性能的天然抗氧化剂。 |
ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
| S3663 |
AfloqualoneAfloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
||
| S4270 |
OxiracetamOxiracetam，γ-氨基丁酸的环状衍生物(GABA)，作为益智药用以改善记忆力和学习。 |
||
| S4700 |
4-Aminobutyric acid (GABA)γ-氨基丁酸(GABA)是一种天然存在的神经递质，具有抑制中枢神经系统的活性。 |
||
| S3748 |
Acamprosate CalciumAcamprosate是一种合成化合物，具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。 |
||
| S6611New |
CyclothiazideCyclothiazide是AMPA-type glutamate receptors（AMPA型谷氨酸受体）正向别构调节剂，在神经发育与功能中发挥关键作用。 |
||
| S5805New |
AllopregnanoloneAllopregnanolone是一种神经类固醇，在脑内由黄体酮合成而来，是高效的GABAA receptor正向别构调节剂。 |
||
| S5131 |
HomotaurineHomotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂，也会抑制HDAC2的蛋白酶体降解，用于治疗癫痫和躁郁症，并预防偏头痛。 |
Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
| S3018 |
Niflumic acidNiflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。 |
||
| S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride是tiagabine的盐酸盐形式，是哌啶甲酸衍生物，具有抗惊厥作用，它是选择性的GABA重吸收抑制剂。 |
||
| S4675 |
TiagabineTiagabine是一种抗惊厥的药物，是GABA重吸收的抑制剂。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1969 |
NefiracetamNefiracetam作用于Ro 5-4864引起的抽搐，是GABAergic，胆碱及单胺类的神经系统增强剂。Phase 2。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1332 |
FlumazenilFlumazenil是一种苯二氮卓类拮抗剂。 |
||
| S6094New |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。 |
||
| S9249New |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
| S9176New |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
||
| s9065New |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
| S7071 |
(+)-Bicuculline(+)-Bicuculline是一种竞争性GABAA受体拮抗剂，IC50为2 μM，也抑制Ca(2+)激活的钾离子通道。 |
Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
|
| S2026 |
Ginkgolide AGinkgolide A是银杏的提取物，是γ-氨基丁酸(GABA)拮抗剂，Ki为14.5 μM。 |
||
| S4587 |
PentylenetetrazolPentylenetetrazol是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。 |
||
| S4197 |
BemegrideBemegride是一种中枢神经系统兴奋剂，及Barbiturate中毒的解毒剂。 |
||
| S5049 |
ThiocolchicosideThiocolchicoside是一种天然存在的配糖体，来源于嘉兰百合的花种中，具有抗炎和止痛活性，同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1338 |
Gabapentin HClGabapentin HCl是一种GABA类似物。 |
||
| S1329 |
EtomidateEtomidate是一种GABAA受体激动剂， 用作短效的麻醉剂或者安定剂。 |
||
| S2133 |
GabapentinGabapentin 是一种GABA类似物，用于治疗癫痫及神经痛。 |
||
| S5612New |
Isonipecotic acidIsonipecotic acid是杂环化合物，主要是作为GABAA receptor部分激动剂发挥作用。 |
||
| S3072 |
(R)-baclofen(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。 |
||
| S4574 |
PiperazinePiperazine是GABA受体的激动剂，是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。 |
||
| S4840 |
BaclofenBaclofen是GABA衍生物，被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors，尤其是GABAB受体。 |
||
| S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone是一种天然类黄酮，与GABAA receptors结合，是GABAA receptors的部分激动剂。 |
||
| S4892 |
PhenibutPhenibut，作为GABA类似物，是靶向中枢神经系统的镇静剂，具有抗焦虑和镇静效果。 |
||
| S2269 |
BaicalinBaicalin 是一种脯氨酰肽链内切酶抑制剂，影响GABA受体。 |
||
| S3786 |
GlabridinGlabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
||
| S2399 |
DihydromyricetinDihydromyricetin 是具有良好性能的天然抗氧化剂。 |
ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
| S3663 |
AfloqualoneAfloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
||
| S4270 |
OxiracetamOxiracetam，γ-氨基丁酸的环状衍生物(GABA)，作为益智药用以改善记忆力和学习。 |
||
| S4700 |
4-Aminobutyric acid (GABA)γ-氨基丁酸(GABA)是一种天然存在的神经递质，具有抑制中枢神经系统的活性。 |
||
| S3748 |
Acamprosate CalciumAcamprosate是一种合成化合物，具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S6611New |
CyclothiazideCyclothiazide是AMPA-type glutamate receptors（AMPA型谷氨酸受体）正向别构调节剂，在神经发育与功能中发挥关键作用。 |
||
| S5805New |
AllopregnanoloneAllopregnanolone是一种神经类固醇，在脑内由黄体酮合成而来，是高效的GABAA receptor正向别构调节剂。 |
||
| S5131 |
HomotaurineHomotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
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