GABA Receptor

信号通路图

研究领域

抑制剂选择性比较

特异性亚型抑制剂

GABA Receptor产品

目录号 产品描述 文献引用 实验数据
S1168

Valproic acid sodium salt (Sodium valproate)

Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂,也会抑制HDAC2的蛋白酶体降解,用于治疗癫痫和躁郁症,并预防偏头痛。Valproic acid 可在小细胞肺癌细胞系中诱导 Notch1 信号转导。Valproic acid (VPA) 正用于研究治疗HIV和各种癌症的方法。Valproic acid (VPA) 通过上调 BNIP3 诱导自噬和线粒体自噬,并通过上调 PGC-1α 来诱导线粒体的生物合成。

S3018

Niflumic acid

Niflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。

S4661

Tiagabine hydrochloride

Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) 是tiagabine的盐酸盐形式,是哌啶甲酸衍生物,具有抗惊厥作用,它是选择性的GABA重吸收抑制剂。

S4675

Tiagabine

Tiagabine (Gabitril, NO050328, NO328, TGB) 是一种抗惊厥的药物,是GABA重吸收的抑制剂。

S6470

Fluralaner

Fluralaner (A1443, AH252723) 是一种口服的系统性的杀虫剂和杀螨剂。Fluralaner抑制 γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors)L-glutamate-gated chloride channels (GluCls)

S1969

Nefiracetam

Nefiracetam (DZL 221)作用于Ro 5-4864引起的抽搐,是GABAergic,胆碱及单胺类的神经系统增强剂。Phase 2。

S4772

alpha-Asarone

Alpha (α)-asarone is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.

S5319

AWD 131-138

AWD 131-138 is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.

S1332

Flumazenil

Flumazenil (RO 15-1788) 是一种苯二氮卓类拮抗剂。

S0303New

CGP52432

CGP52432 是一种有效的 GABAB autoreceptor 的选择性拮抗剂,其IC50值为0.085 μM。

S7071

(+)-Bicuculline

(+)-Bicuculline是一种竞争性GABAA受体拮抗剂,IC50为2 μM,也抑制Ca(2+)激活的钾离子通道。

S9249

Securinine

Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.

S2026

Ginkgolide A

Ginkgolide A (BN52020) 是银杏的提取物,是γ-氨基丁酸(GABA)拮抗剂,Ki为14.5 μM。

S4587

Pentylenetetrazol

Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ)是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。

S6008

p-Hydroxybenzaldehyde

p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol),存在于兰花Gastrodia elataGaleola faberi和香草中,是一种羟基苯甲醛,可与NAD+和H20反应生成4-hydroxybenzoate、NADH和两质子。

S9065

Songorine

Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.

S4197

Bemegride

Bemegride是一种中枢神经系统兴奋剂,及Barbiturate中毒的解毒剂。

S5049

Thiocolchicoside

Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) 是一种天然存在的配糖体,来源于嘉兰百合的花种中,具有抗炎和止痛活性,同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。

S6094

Imidazole-4(5)-acetic Acid Hydrochloride

Imidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。

S9176

Pimpinellin

Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.

S1338

Gabapentin HCl

Gabapentin HCl是一种GABA类似物。

S1329

Etomidate

Etomidate (R16659)是一种GABAA受体激动剂, 用作短效的麻醉剂或者安定剂。

S2133

Gabapentin

Gabapentin 是一种GABA类似物,用于治疗癫痫及神经痛。

S3072

(R)-baclofen

(R)-baclofen (STX 209)是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。

S4574

Piperazine

Piperazine (1,4-Diazacyclohexane, Diethylenediamine, exahydropyrazine, Piperazidine) 是GABA受体的激动剂,是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。

S4840

Baclofen

Baclofen是GABA衍生物,被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors,尤其是GABAB受体。

S3634

6-Hydroxyflavone (6-HF)

6-Hydroxyflavone是一种天然类黄酮,与GABAA receptors结合,是GABAA receptors的部分激动剂。

S4892

Phenibut

Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA),作为GABA类似物,是靶向中枢神经系统的镇静剂,具有抗焦虑和镇静效果。

S2269

Baicalin

Baicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。

S4961

3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid (TMCA)是Polygalae Radix的成分之一,可能通过作用于GABAA/BZ受体复合体而发挥抗癫痫活性。

S3786

Glabridin

Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.

S2399

Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。

S3663

Afloqualone

Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.

S4270

Oxiracetam

Oxiracetam (ISF 2522),γ-氨基丁酸的环状衍生物(GABA),作为益智药用以改善记忆力和学习。

S4700

4-Aminobutyric acid (GABA)

4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。

S3748

Acamprosate Calcium

Acamprosate是一种合成化合物,具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。

S5612

Isonipecotic acid

Isonipecotic acid是杂环化合物,主要是作为GABAA receptor部分激动剂发挥作用。

S6755New

NS 11394

NS11394是GABAA受体的正向别构调节剂,对α3和α5亚型具有选择性。

S5131

Homotaurine

Homotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.

S3959

(+)-Borneol

(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.

S5596

(1S)-(-)-α-Pinene

α-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity.

S5805

Allopregnanolone

Allopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。

S6611

Cyclothiazide

Cyclothiazide是AMPA-type glutamate receptors(AMPA型谷氨酸受体)正向别构调节剂,在神经发育与功能中发挥关键作用。

S9409

Kavain

Kavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.

S3977

(-)-Borneol

(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor.

目录号 产品描述 文献引用 实验数据
S1168

Valproic acid sodium salt (Sodium valproate)

Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂,也会抑制HDAC2的蛋白酶体降解,用于治疗癫痫和躁郁症,并预防偏头痛。Valproic acid 可在小细胞肺癌细胞系中诱导 Notch1 信号转导。Valproic acid (VPA) 正用于研究治疗HIV和各种癌症的方法。Valproic acid (VPA) 通过上调 BNIP3 诱导自噬和线粒体自噬,并通过上调 PGC-1α 来诱导线粒体的生物合成。

S3018

Niflumic acid

Niflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。

S4661

Tiagabine hydrochloride

Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) 是tiagabine的盐酸盐形式,是哌啶甲酸衍生物,具有抗惊厥作用,它是选择性的GABA重吸收抑制剂。

S4675

Tiagabine

Tiagabine (Gabitril, NO050328, NO328, TGB) 是一种抗惊厥的药物,是GABA重吸收的抑制剂。

S6470

Fluralaner

Fluralaner (A1443, AH252723) 是一种口服的系统性的杀虫剂和杀螨剂。Fluralaner抑制 γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors)L-glutamate-gated chloride channels (GluCls)

目录号 产品描述 文献引用 实验数据
S1969

Nefiracetam

Nefiracetam (DZL 221)作用于Ro 5-4864引起的抽搐,是GABAergic,胆碱及单胺类的神经系统增强剂。Phase 2。

S4772

alpha-Asarone

Alpha (α)-asarone is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.

S5319

AWD 131-138

AWD 131-138 is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.

目录号 产品描述 文献引用 实验数据
S1332

Flumazenil

Flumazenil (RO 15-1788) 是一种苯二氮卓类拮抗剂。

S0303New

CGP52432

CGP52432 是一种有效的 GABAB autoreceptor 的选择性拮抗剂,其IC50值为0.085 μM。

S7071

(+)-Bicuculline

(+)-Bicuculline是一种竞争性GABAA受体拮抗剂,IC50为2 μM,也抑制Ca(2+)激活的钾离子通道。

S9249

Securinine

Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.

S2026

Ginkgolide A

Ginkgolide A (BN52020) 是银杏的提取物,是γ-氨基丁酸(GABA)拮抗剂,Ki为14.5 μM。

S4587

Pentylenetetrazol

Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ)是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。

S6008

p-Hydroxybenzaldehyde

p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol),存在于兰花Gastrodia elataGaleola faberi和香草中,是一种羟基苯甲醛,可与NAD+和H20反应生成4-hydroxybenzoate、NADH和两质子。

S9065

Songorine

Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.

S4197

Bemegride

Bemegride是一种中枢神经系统兴奋剂,及Barbiturate中毒的解毒剂。

S5049

Thiocolchicoside

Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) 是一种天然存在的配糖体,来源于嘉兰百合的花种中,具有抗炎和止痛活性,同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。

S6094

Imidazole-4(5)-acetic Acid Hydrochloride

Imidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。

S9176

Pimpinellin

Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.

目录号 产品描述 文献引用 实验数据
S1338

Gabapentin HCl

Gabapentin HCl是一种GABA类似物。

S1329

Etomidate

Etomidate (R16659)是一种GABAA受体激动剂, 用作短效的麻醉剂或者安定剂。

S2133

Gabapentin

Gabapentin 是一种GABA类似物,用于治疗癫痫及神经痛。

S3072

(R)-baclofen

(R)-baclofen (STX 209)是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。

S4574

Piperazine

Piperazine (1,4-Diazacyclohexane, Diethylenediamine, exahydropyrazine, Piperazidine) 是GABA受体的激动剂,是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。

S4840

Baclofen

Baclofen是GABA衍生物,被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors,尤其是GABAB受体。

S3634

6-Hydroxyflavone (6-HF)

6-Hydroxyflavone是一种天然类黄酮,与GABAA receptors结合,是GABAA receptors的部分激动剂。

S4892

Phenibut

Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA),作为GABA类似物,是靶向中枢神经系统的镇静剂,具有抗焦虑和镇静效果。

S2269

Baicalin

Baicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。

S4961

3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid (TMCA)是Polygalae Radix的成分之一,可能通过作用于GABAA/BZ受体复合体而发挥抗癫痫活性。

S3786

Glabridin

Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.

S2399

Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。

S3663

Afloqualone

Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.

S4270

Oxiracetam

Oxiracetam (ISF 2522),γ-氨基丁酸的环状衍生物(GABA),作为益智药用以改善记忆力和学习。

S4700

4-Aminobutyric acid (GABA)

4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。

S3748

Acamprosate Calcium

Acamprosate是一种合成化合物,具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。

S5612

Isonipecotic acid

Isonipecotic acid是杂环化合物,主要是作为GABAA receptor部分激动剂发挥作用。

目录号 产品描述 文献引用 实验数据
S6755New

NS 11394

NS11394是GABAA受体的正向别构调节剂,对α3和α5亚型具有选择性。

S5131

Homotaurine

Homotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.

S3959

(+)-Borneol

(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.

S5596

(1S)-(-)-α-Pinene

α-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity.

S5805

Allopregnanolone

Allopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。

S6611

Cyclothiazide

Cyclothiazide是AMPA-type glutamate receptors(AMPA型谷氨酸受体)正向别构调节剂,在神经发育与功能中发挥关键作用。

S9409

Kavain

Kavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.

S3977

(-)-Borneol

(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor.

Tags: GABA inhibition | GABA receptor activation | GABA function | GABA drugs | GABA activity | GABA pathway | GABA-A receptor function | GABA receptor function | GABA activation | gamma aminobutyric acid function | GABA cancer | GABA assay | GABA receptor drugs | GABA receptor inhibition | GABA receptor signaling | GABA receptors review | GABA agonists list | GABA antagonist drugs | GABA inhibitor drugs | GABA inhibitor review