GABA Receptor
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1168 | Valproic acid sodium salt (Sodium valproate) | 33 mg/mL | 33 mg/mL | 33 mg/mL |
| S3018 | Niflumic acid | <1 mg/mL | 56 mg/mL | <1 mg/mL |
| S4661 | Tiagabine hydrochloride | 11 mg/mL | 82 mg/mL | 82 mg/mL |
| S1969 | Nefiracetam | 5 mg/mL | 49 mg/mL | 49 mg/mL |
| S1332 | Flumazenil | <1 mg/mL | 5 mg/mL | <1 mg/mL |
| S9249 | Securinine | -1 mg/mL | 44 mg/mL | -1 mg/mL |
| S9176 | Pimpinellin | -1 mg/mL | 49 mg/mL | -1 mg/mL |
| s9065 | Songorine | -1 mg/mL | 71 mg/mL | -1 mg/mL |
| S5049 | Thiocolchicoside | 100 mg/mL | 100 mg/mL | 2 mg/mL |
| S7071 | (+)-Bicuculline | <1 mg/mL | 21 mg/mL | <1 mg/mL |
| S2026 | Ginkgolide A | <1 mg/mL | 81 mg/mL | 2 mg/mL |
| S4587 | Pentylenetetrazol | 27 mg/mL | 27 mg/mL | 27 mg/mL |
| S4197 | Bemegride | <1 mg/mL | 31 mg/mL | 31 mg/mL |
| S1338 | Gabapentin HCl | 42 mg/mL | <1 mg/mL | <1 mg/mL |
| S1329 | Etomidate | <1 mg/mL | 49 mg/mL | 49 mg/mL |
| S2133 | Gabapentin | 34 mg/mL | <1 mg/mL | <1 mg/mL |
| S4840 | Baclofen | 0.1 mg/mL | <1 mg/mL | <1 mg/mL |
| S4892 | Phenibut | -1 mg/mL | 35 mg/mL | -1 mg/mL |
| S3072 | (R)-baclofen | 8 mg/mL | <1 mg/mL | <1 mg/mL |
| S4574 | Piperazine | 17 mg/mL | 8 mg/mL | 17 mg/mL |
| S3634 | 6-Hydroxyflavone (6-HF) | <1 mg/mL | 47 mg/mL | <1 mg/mL |
| S2269 | Baicalin | <1 mg/mL | 89 mg/mL | <1 mg/mL |
| S3786 | Glabridin | -1 mg/mL | 64 mg/mL | -1 mg/mL |
| S2399 | Dihydromyricetin | <1 mg/mL | 64 mg/mL | 64 mg/mL |
| S3663 | Afloqualone | <1 mg/mL | 56 mg/mL | 28 mg/mL |
| S4270 | Oxiracetam | 31 mg/mL | 31 mg/mL | <1 mg/mL |
| S4700 | 4-Aminobutyric acid (GABA) | 20 mg/mL | <1 mg/mL | <1 mg/mL |
| S3748 | Acamprosate Calcium | 40 mg/mL | <1 mg/mL | <1 mg/mL |
| S5805 | Allopregnanolone | <1 mg/mL | 64 mg/mL | 31 mg/mL |
- GABA Receptor抑制剂（31）
- 新GABA Receptor产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂，也会抑制HDAC2的蛋白酶体降解，用于治疗癫痫和躁郁症，并预防偏头痛。 |
(A,B) Wild-type C57BL/6 male mice were treated with vehicle (saline) or 10 mg/kg of paraquat (PQ) for 3 days, and mice received VPA (3.5 mg/kg) or anacardic acid (5 mg/kg) starting 24 and 1 h before PQ injection. IL-6 mRNA expression was determined by real-time PCR.
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| S3018 |
Niflumic acidNiflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。 |
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| S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride是tiagabine的盐酸盐形式，是哌啶甲酸衍生物，具有抗惊厥作用，它是选择性的GABA重吸收抑制剂。 |
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| S4675 |
TiagabineTiagabine是一种抗惊厥的药物，是GABA重吸收的抑制剂。 |
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| S1969 |
NefiracetamNefiracetam作用于Ro 5-4864引起的抽搐，是GABAergic，胆碱及单胺类的神经系统增强剂。Phase 2。 |
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| S1332 |
FlumazenilFlumazenil是一种苯二氮卓类拮抗剂。 |
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| S9249New |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
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| S9176New |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
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| s9065New |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
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| S5049New |
ThiocolchicosideThiocolchicoside是一种天然存在的配糖体，来源于嘉兰百合的花种中，具有抗炎和止痛活性，同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
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| S7071 |
(+)-Bicuculline(+)-Bicuculline是一种竞争性GABAA受体拮抗剂，IC50为2 μM，也抑制Ca(2+)激活的钾离子通道。 |
-Bicuculline-S707101X0320161109.gif)
-Bicuculline-S707101X0320161109.gif)
Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
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| S2026 |
Ginkgolide AGinkgolide A是银杏的提取物，是γ-氨基丁酸(GABA)拮抗剂，Ki为14.5 μM。 |
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| S4587 |
PentylenetetrazolPentylenetetrazol是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。 |
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| S4197 |
BemegrideBemegride是一种中枢神经系统兴奋剂，及Barbiturate中毒的解毒剂。 |
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| S1338 |
Gabapentin HClGabapentin HCl是一种GABA类似物。 |
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| S1329 |
EtomidateEtomidate是一种GABAA受体激动剂， 用作短效的麻醉剂或者安定剂。 |
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| S2133 |
GabapentinGabapentin 是一种GABA类似物，用于治疗癫痫及神经痛。 |
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| S4840New |
BaclofenBaclofen是GABA衍生物，被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors，尤其是GABAB受体。 |
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| S4892New |
PhenibutPhenibut，作为GABA类似物，是靶向中枢神经系统的镇静剂，具有抗焦虑和镇静效果。 |
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| S3072 |
(R)-baclofen(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。 |
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| S4574 |
PiperazinePiperazine是GABA受体的激动剂，是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。 |
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| S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone是一种天然类黄酮，与GABAA receptors结合，是GABAA receptors的部分激动剂。 |
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| S2269 |
BaicalinBaicalin 是一种脯氨酰肽链内切酶抑制剂，影响GABA受体。 |
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| S3786 |
GlabridinGlabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
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| S2399 |
DihydromyricetinDihydromyricetin 是具有良好性能的天然抗氧化剂。 |
A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm. |
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| S3663 |
AfloqualoneAfloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
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| S4270 |
OxiracetamOxiracetam，γ-氨基丁酸的环状衍生物(GABA)，作为益智药用以改善记忆力和学习。 |
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| S4700 |
4-Aminobutyric acid (GABA)γ-氨基丁酸(GABA)是一种天然存在的神经递质，具有抑制中枢神经系统的活性。 |
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| S3748 |
Acamprosate CalciumAcamprosate是一种合成化合物，具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。 |
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| S5805New |
AllopregnanoloneAllopregnanolone是一种神经类固醇，在脑内由黄体酮合成而来，是高效的GABAA receptor正向别构调节剂。 |
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| S5131New |
HomotaurineHomotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
