GABA Receptor
GABA Receptor产品
产品目录 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂,也会抑制HDAC2的蛋白酶体降解,用于治疗癫痫和躁郁症,并预防偏头痛。 |
![]() ![]() Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
S3018 |
Niflumic acidNiflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。 |
||
S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride是tiagabine的盐酸盐形式,是哌啶甲酸衍生物,具有抗惊厥作用,它是选择性的GABA重吸收抑制剂。 |
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S4675 |
TiagabineTiagabine是一种抗惊厥的药物,是GABA重吸收的抑制剂。 |
||
S1969 |
NefiracetamNefiracetam作用于Ro 5-4864引起的抽搐,是GABAergic,胆碱及单胺类的神经系统增强剂。Phase 2。 |
||
S1332 |
FlumazenilFlumazenil是一种苯二氮卓类拮抗剂。 |
||
S6094New |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。 |
||
S7071 |
(+)-Bicuculline(+)-Bicuculline是一种竞争性GABAA受体拮抗剂,IC50为2 μM,也抑制Ca(2+)激活的钾离子通道。 |
![]() ![]() Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
|
S9249 |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
S2026 |
Ginkgolide AGinkgolide A是银杏的提取物,是γ-氨基丁酸(GABA)拮抗剂,Ki为14.5 μM。 |
||
S4587 |
PentylenetetrazolPentylenetetrazol是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。 |
||
s9065 |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
S4197 |
BemegrideBemegride是一种中枢神经系统兴奋剂,及Barbiturate中毒的解毒剂。 |
||
S5049 |
ThiocolchicosideThiocolchicoside是一种天然存在的配糖体,来源于嘉兰百合的花种中,具有抗炎和止痛活性,同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
||
S9176 |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
||
S1338 |
Gabapentin HClGabapentin HCl是一种GABA类似物。 |
||
S1329 |
EtomidateEtomidate是一种GABAA受体激动剂, 用作短效的麻醉剂或者安定剂。 |
||
S2133 |
GabapentinGabapentin 是一种GABA类似物,用于治疗癫痫及神经痛。 |
||
S5612New |
Isonipecotic acidIsonipecotic acid是杂环化合物,主要是作为GABAA receptor部分激动剂发挥作用。 |
||
S3072 |
(R)-baclofen(R)-baclofen是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。 |
||
S4574 |
PiperazinePiperazine是GABA受体的激动剂,是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。 |
||
S4840 |
BaclofenBaclofen是GABA衍生物,被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors,尤其是GABAB受体。 |
||
S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone是一种天然类黄酮,与GABAA receptors结合,是GABAA receptors的部分激动剂。 |
||
S4892 |
PhenibutPhenibut,作为GABA类似物,是靶向中枢神经系统的镇静剂,具有抗焦虑和镇静效果。 |
||
S2269 |
BaicalinBaicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。 |
||
S3786 |
GlabridinGlabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
||
S2399 |
DihydromyricetinDihydromyricetin 是具有良好性能的天然抗氧化剂。 |
![]() ![]() ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
S3663 |
AfloqualoneAfloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
||
S4270 |
OxiracetamOxiracetam,γ-氨基丁酸的环状衍生物(GABA),作为益智药用以改善记忆力和学习。 |
||
S4700 |
4-Aminobutyric acid (GABA)γ-氨基丁酸(GABA)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。 |
||
S3748 |
Acamprosate CalciumAcamprosate是一种合成化合物,具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。 |
||
S6755New |
NS 11394NS11394是GABAA受体的正向别构调节剂,对α3和α5亚型具有选择性。 |
||
S6611New |
CyclothiazideCyclothiazide是AMPA-type glutamate receptors(AMPA型谷氨酸受体)正向别构调节剂,在神经发育与功能中发挥关键作用。 |
||
S5805New |
AllopregnanoloneAllopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。 |
||
S5131 |
HomotaurineHomotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
产品目录 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂,也会抑制HDAC2的蛋白酶体降解,用于治疗癫痫和躁郁症,并预防偏头痛。 |
![]() ![]() Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
S3018 |
Niflumic acidNiflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。 |
||
S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride是tiagabine的盐酸盐形式,是哌啶甲酸衍生物,具有抗惊厥作用,它是选择性的GABA重吸收抑制剂。 |
||
S4675 |
TiagabineTiagabine是一种抗惊厥的药物,是GABA重吸收的抑制剂。 |
产品目录 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1969 |
NefiracetamNefiracetam作用于Ro 5-4864引起的抽搐,是GABAergic,胆碱及单胺类的神经系统增强剂。Phase 2。 |
产品目录 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1332 |
FlumazenilFlumazenil是一种苯二氮卓类拮抗剂。 |
||
S6094New |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。 |
||
S7071 |
(+)-Bicuculline(+)-Bicuculline是一种竞争性GABAA受体拮抗剂,IC50为2 μM,也抑制Ca(2+)激活的钾离子通道。 |
![]() ![]() Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
|
S9249 |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
S2026 |
Ginkgolide AGinkgolide A是银杏的提取物,是γ-氨基丁酸(GABA)拮抗剂,Ki为14.5 μM。 |
||
S4587 |
PentylenetetrazolPentylenetetrazol是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。 |
||
s9065 |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
S4197 |
BemegrideBemegride是一种中枢神经系统兴奋剂,及Barbiturate中毒的解毒剂。 |
||
S5049 |
ThiocolchicosideThiocolchicoside是一种天然存在的配糖体,来源于嘉兰百合的花种中,具有抗炎和止痛活性,同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
||
S9176 |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
产品目录 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1338 |
Gabapentin HClGabapentin HCl是一种GABA类似物。 |
||
S1329 |
EtomidateEtomidate是一种GABAA受体激动剂, 用作短效的麻醉剂或者安定剂。 |
||
S2133 |
GabapentinGabapentin 是一种GABA类似物,用于治疗癫痫及神经痛。 |
||
S5612New |
Isonipecotic acidIsonipecotic acid是杂环化合物,主要是作为GABAA receptor部分激动剂发挥作用。 |
||
S3072 |
(R)-baclofen(R)-baclofen是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。 |
||
S4574 |
PiperazinePiperazine是GABA受体的激动剂,是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。 |
||
S4840 |
BaclofenBaclofen是GABA衍生物,被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors,尤其是GABAB受体。 |
||
S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone是一种天然类黄酮,与GABAA receptors结合,是GABAA receptors的部分激动剂。 |
||
S4892 |
PhenibutPhenibut,作为GABA类似物,是靶向中枢神经系统的镇静剂,具有抗焦虑和镇静效果。 |
||
S2269 |
BaicalinBaicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。 |
||
S3786 |
GlabridinGlabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
||
S2399 |
DihydromyricetinDihydromyricetin 是具有良好性能的天然抗氧化剂。 |
![]() ![]() ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
S3663 |
AfloqualoneAfloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
||
S4270 |
OxiracetamOxiracetam,γ-氨基丁酸的环状衍生物(GABA),作为益智药用以改善记忆力和学习。 |
||
S4700 |
4-Aminobutyric acid (GABA)γ-氨基丁酸(GABA)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。 |
||
S3748 |
Acamprosate CalciumAcamprosate是一种合成化合物,具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。 |
产品目录 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S6755New |
NS 11394NS11394是GABAA受体的正向别构调节剂,对α3和α5亚型具有选择性。 |
||
S6611New |
CyclothiazideCyclothiazide是AMPA-type glutamate receptors(AMPA型谷氨酸受体)正向别构调节剂,在神经发育与功能中发挥关键作用。 |
||
S5805New |
AllopregnanoloneAllopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。 |
||
S5131 |
HomotaurineHomotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |