GABA Receptor
GABA Receptor产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂,也会抑制HDAC2的蛋白酶体降解,用于治疗癫痫和躁郁症,并预防偏头痛。Valproic acid 可在小细胞肺癌细胞系中诱导 Notch1 信号转导。Valproic acid (VPA) 正用于研究治疗HIV和各种癌症的方法。Valproic acid (VPA) 通过上调 BNIP3 诱导自噬和线粒体自噬,并通过上调 PGC-1α 来诱导线粒体的生物合成。 |
![]() ![]() Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
S2996New |
L-DAB HBRL-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) 是一种 GABA (Gamma-aminobutyric acid) transaminase 的抑制剂,IC50值大于500 μM。L-DAB HBR 表现出抗肿瘤活性。 |
||
S3018 |
Niflumic acidNiflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。 |
||
S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) 是tiagabine的盐酸盐形式,是哌啶甲酸衍生物,具有抗惊厥作用,它是选择性的GABA重吸收抑制剂。 |
||
S4675 |
TiagabineTiagabine (Gabitril, NO050328, NO328, TGB) 是一种抗惊厥的药物,是GABA重吸收的抑制剂。 |
||
S6470 |
FluralanerFluralaner (A1443, AH252723) 是一种口服的系统性的杀虫剂和杀螨剂。Fluralaner抑制 γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) 和 L-glutamate-gated chloride channels (GluCls)。 |
||
S1969 |
NefiracetamNefiracetam (DZL 221)作用于Ro 5-4864引起的抽搐,是GABAergic,胆碱及单胺类的神经系统增强剂。Phase 2。 |
||
S4772 |
alpha-AsaroneAlpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects. |
||
S5319 |
AWD 131-138AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. |
||
S1332 |
FlumazenilFlumazenil (RO 15-1788) 是一种苯二氮卓类拮抗剂。 |
||
S0303New |
CGP52432CGP52432 是一种有效的 GABAB autoreceptor 的选择性拮抗剂,其IC50值为0.085 μM。 |
||
S7071 |
(+)-Bicuculline(+)-Bicuculline是一种竞争性GABAA受体拮抗剂,IC50为2 μM,也抑制Ca(2+)激活的钾离子通道。 |
![]() ![]() Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
|
S9249 |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
S2026 |
Ginkgolide AGinkgolide A (BN52020) 是银杏的提取物,是γ-氨基丁酸(GABA)拮抗剂,Ki为14.5 μM。 |
||
S4587 |
PentylenetetrazolPentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ)是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。 |
||
S6008 |
p-Hydroxybenzaldehydep-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol),存在于兰花Gastrodia elata、Galeola faberi和香草中,是一种羟基苯甲醛,可与NAD+和H20反应生成4-hydroxybenzoate、NADH和两质子。 |
||
S9065 |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
S4197 |
BemegrideBemegride是一种中枢神经系统兴奋剂,及Barbiturate中毒的解毒剂。 |
||
S5049 |
ThiocolchicosideThiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) 是一种天然存在的配糖体,来源于嘉兰百合的花种中,具有抗炎和止痛活性,同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
||
S6094 |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。 |
||
S9176 |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
||
S1338 |
Gabapentin HClGabapentin HCl是一种GABA类似物。 |
||
S1329 |
EtomidateEtomidate (R16659)是一种GABAA受体激动剂, 用作短效的麻醉剂或者安定剂。 |
||
S2133 |
GabapentinGabapentin 是一种GABA类似物,用于治疗癫痫及神经痛。 |
||
S3072 |
(R)-baclofen(R)-baclofen (STX 209)是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。 |
||
S4574 |
PiperazinePiperazine (1,4-Diazacyclohexane, Diethylenediamine, exahydropyrazine, Piperazidine) 是GABA受体的激动剂,是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。 |
||
S4840 |
BaclofenBaclofen是GABA衍生物,被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors,尤其是GABAB受体。 |
||
S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone是一种天然类黄酮,与GABAA receptors结合,是GABAA receptors的部分激动剂。 |
||
S4892 |
PhenibutPhenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA),作为GABA类似物,是靶向中枢神经系统的镇静剂,具有抗焦虑和镇静效果。 |
||
S2269 |
BaicalinBaicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。 |
||
S4961 |
3,4,5-Trimethoxycinnamic acid3,4,5-Trimethoxycinnamic acid (TMCA)是Polygalae Radix的成分之一,可能通过作用于GABAA/BZ受体复合体而发挥抗癫痫活性。 |
||
S3786 |
GlabridinGlabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
||
S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。 |
![]() ![]() ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
S3663 |
AfloqualoneAfloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
||
S4270 |
OxiracetamOxiracetam (ISF 2522),γ-氨基丁酸的环状衍生物(GABA),作为益智药用以改善记忆力和学习。 |
||
S4700 |
4-Aminobutyric acid (GABA)4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。 |
||
S3748 |
Acamprosate CalciumAcamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate)是一种合成化合物,具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。 |
||
S5612 |
Isonipecotic acidIsonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid)是杂环化合物,主要是作为GABAA receptor部分激动剂发挥作用。 |
||
S5131 |
HomotaurineHomotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
||
S3959 |
(+)-Borneol(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine. |
||
S5596 |
(1S)-(-)-α-Pineneα-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity. |
||
S5805 |
AllopregnanoloneAllopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。 |
||
S6611 |
CyclothiazideCyclothiazide是AMPA-type glutamate receptors(AMPA型谷氨酸受体)正向别构调节剂,在神经发育与功能中发挥关键作用。 |
||
S9409 |
KavainKavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. |
||
S3977 |
(-)-Borneol(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. |
||
S6755 |
NS 11394NS11394是GABAA受体的正向别构调节剂,对α3和α5亚型具有选择性。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂,也会抑制HDAC2的蛋白酶体降解,用于治疗癫痫和躁郁症,并预防偏头痛。Valproic acid 可在小细胞肺癌细胞系中诱导 Notch1 信号转导。Valproic acid (VPA) 正用于研究治疗HIV和各种癌症的方法。Valproic acid (VPA) 通过上调 BNIP3 诱导自噬和线粒体自噬,并通过上调 PGC-1α 来诱导线粒体的生物合成。 |
![]() ![]() Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
S2996New |
L-DAB HBRL-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) 是一种 GABA (Gamma-aminobutyric acid) transaminase 的抑制剂,IC50值大于500 μM。L-DAB HBR 表现出抗肿瘤活性。 |
||
S3018 |
Niflumic acidNiflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。 |
||
S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) 是tiagabine的盐酸盐形式,是哌啶甲酸衍生物,具有抗惊厥作用,它是选择性的GABA重吸收抑制剂。 |
||
S4675 |
TiagabineTiagabine (Gabitril, NO050328, NO328, TGB) 是一种抗惊厥的药物,是GABA重吸收的抑制剂。 |
||
S6470 |
FluralanerFluralaner (A1443, AH252723) 是一种口服的系统性的杀虫剂和杀螨剂。Fluralaner抑制 γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) 和 L-glutamate-gated chloride channels (GluCls)。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1969 |
NefiracetamNefiracetam (DZL 221)作用于Ro 5-4864引起的抽搐,是GABAergic,胆碱及单胺类的神经系统增强剂。Phase 2。 |
||
S4772 |
alpha-AsaroneAlpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects. |
||
S5319 |
AWD 131-138AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1332 |
FlumazenilFlumazenil (RO 15-1788) 是一种苯二氮卓类拮抗剂。 |
||
S0303New |
CGP52432CGP52432 是一种有效的 GABAB autoreceptor 的选择性拮抗剂,其IC50值为0.085 μM。 |
||
S7071 |
(+)-Bicuculline(+)-Bicuculline是一种竞争性GABAA受体拮抗剂,IC50为2 μM,也抑制Ca(2+)激活的钾离子通道。 |
![]() ![]() Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
|
S9249 |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
S2026 |
Ginkgolide AGinkgolide A (BN52020) 是银杏的提取物,是γ-氨基丁酸(GABA)拮抗剂,Ki为14.5 μM。 |
||
S4587 |
PentylenetetrazolPentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ)是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。 |
||
S6008 |
p-Hydroxybenzaldehydep-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol),存在于兰花Gastrodia elata、Galeola faberi和香草中,是一种羟基苯甲醛,可与NAD+和H20反应生成4-hydroxybenzoate、NADH和两质子。 |
||
S9065 |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
S4197 |
BemegrideBemegride是一种中枢神经系统兴奋剂,及Barbiturate中毒的解毒剂。 |
||
S5049 |
ThiocolchicosideThiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) 是一种天然存在的配糖体,来源于嘉兰百合的花种中,具有抗炎和止痛活性,同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
||
S6094 |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride是GABAC receptors竞争性拮抗剂。 |
||
S9176 |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1338 |
Gabapentin HClGabapentin HCl是一种GABA类似物。 |
||
S1329 |
EtomidateEtomidate (R16659)是一种GABAA受体激动剂, 用作短效的麻醉剂或者安定剂。 |
||
S2133 |
GabapentinGabapentin 是一种GABA类似物,用于治疗癫痫及神经痛。 |
||
S3072 |
(R)-baclofen(R)-baclofen (STX 209)是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。 |
||
S4574 |
PiperazinePiperazine (1,4-Diazacyclohexane, Diethylenediamine, exahydropyrazine, Piperazidine) 是GABA受体的激动剂,是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。 |
||
S4840 |
BaclofenBaclofen是GABA衍生物,被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors,尤其是GABAB受体。 |
||
S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone是一种天然类黄酮,与GABAA receptors结合,是GABAA receptors的部分激动剂。 |
||
S4892 |
PhenibutPhenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA),作为GABA类似物,是靶向中枢神经系统的镇静剂,具有抗焦虑和镇静效果。 |
||
S2269 |
BaicalinBaicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。 |
||
S4961 |
3,4,5-Trimethoxycinnamic acid3,4,5-Trimethoxycinnamic acid (TMCA)是Polygalae Radix的成分之一,可能通过作用于GABAA/BZ受体复合体而发挥抗癫痫活性。 |
||
S3786 |
GlabridinGlabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
||
S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。 |
![]() ![]() ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
S3663 |
AfloqualoneAfloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
||
S4270 |
OxiracetamOxiracetam (ISF 2522),γ-氨基丁酸的环状衍生物(GABA),作为益智药用以改善记忆力和学习。 |
||
S4700 |
4-Aminobutyric acid (GABA)4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。 |
||
S3748 |
Acamprosate CalciumAcamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate)是一种合成化合物,具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。 |
||
S5612 |
Isonipecotic acidIsonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid)是杂环化合物,主要是作为GABAA receptor部分激动剂发挥作用。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S5131 |
HomotaurineHomotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
||
S3959 |
(+)-Borneol(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine. |
||
S5596 |
(1S)-(-)-α-Pineneα-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity. |
||
S5805 |
AllopregnanoloneAllopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。 |
||
S6611 |
CyclothiazideCyclothiazide是AMPA-type glutamate receptors(AMPA型谷氨酸受体)正向别构调节剂,在神经发育与功能中发挥关键作用。 |
||
S9409 |
KavainKavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. |
||
S3977 |
(-)-Borneol(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. |
||
S6755 |
NS 11394NS11394是GABAA受体的正向别构调节剂,对α3和α5亚型具有选择性。 |