Pim抑制剂 | Pim Inhibitor

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PD-1/PD-L1治疗性抗体（Pembrolizumab，Atezolizumab，Nivolumab）重磅上市！

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抑制剂
- 研究领域
- PI3K/Akt/mTOR
  - PI3K
  - mTOR
  - Akt
  - GSK-3
  - ATM/ATR
  - PDK
  - S6 Kinase
  - AMPK
  - DNA-PK
  - MELK
- Epigenetics
- Methylation
  - DNA Methyltransferase
  - LSD1
  - DOT1
  - COMT
  - EZH1/2
  - MLL
  - PPMTase
  - SETD
  - SAM MTase
  - PRMT
  - WDR5
  - G9a/GLP
  - SMYD2
  - JMJD
  - HNMT
- Immunology & Inflammation
  - PD-1/PD-L1
  - COX
  - CCR
  - Histamine Receptor
  - IL Receptor
  - ROS
  - TLR
  - NOS
  - NADPH-oxidase
  - Leukotriene Receptor
  - MALT
  - CXCR
  - gp120/CD4
  - Nrf2
  - Immunology & Inflammation related
- Protein Tyrosine Kinase
  - VEGFR
  - EGFR
  - PDGFR
  - c-Met
  - HER2
  - IGF-1R
  - FLT3
  - FGFR
  - c-Kit
  - Src
  - ALK
  - Tie-2
  - c-RET
  - ACK
  - Axl
  - Trk receptor
  - Ephrin Receptor
  - CSF-1R
  - BTK
- Angiogenesis
  - VEGFR
  - JAK
  - EGFR
  - PDGFR
  - HER2
  - FLT3
  - FGFR
  - HIF
  - VDA
  - Bcr-Abl
  - Src
  - ALK
  - Syk
  - FAK
  - BTK
- Apoptosis
  - PD-1/PD-L1
  - Bcl-2
  - Caspase
  - p53
  - TNF-alpha
  - Mdm2
  - Survivin
  - c-RET
  - IAP
  - PERK
  - ASK
  - Serine/threonin kinase
  - Bcl-6
- Autophagy
  - Autophagy
  - CXCR
  - LRRK2
- ER stress & UPR
  - JNK
  - HSP e.g. HSP90
  - PERK
  - ASK
  - IRE1
  - PDI
- JAK/STAT
  - JAK
  - STAT
  - EGFR
  - Pim
- MAPK
  - MEK
  - Raf
  - p38 MAPK
  - JNK
  - TOPK
  - MNK
  - ERK
- Cytoskeletal Signaling
  - Akt
  - Wnt/beta-catenin
  - Bcr-Abl
  - PKC
  - FAK
  - HSP e.g. HSP90
  - Kinesin
  - Microtubule Associated
  - Integrin
  - PAK
  - Dynamin
- Cell Cycle
  - CDK
  - PD-1/PD-L1
  - Aurora Kinase
  - Chk
  - ROCK
  - PLK
  - APC
  - Wee1
  - Rho
  - c-Myc
  - DYRK
  - BMI-1
- TGF-beta/Smad
  - TGF-beta/Smad
  - Bcr-Abl
  - PKC
  - ROCK
- DNA Damage
  - HDAC
  - ATM/ATR
  - PARP
  - DNA/RNA Synthesis
  - Sirtuin
  - Topoisomerase
  - DNA-PK
  - Telomerase
  - MTH1
  - High-mobility Group
  - DNA alkylator
  - CRISPR/Cas9
  - BMI-1
- Stem Cells & Wnt
- Ubiquitin
  - Proteasome
  - DUB
  - p97
  - SUMO
  - E2 conjugating
  - E1 Activating
  - E3 Ligase
- Neuronal Signaling
  - Beta Amyloid
  - 5-HT Receptor
  - COX
  - Gamma-secretase
  - GluR
  - Adrenergic Receptor
  - AChR
  - Histamine Receptor
  - Dopamine Receptor
  - Opioid Receptor
  - GABA Receptor
  - P-gp
  - P2 Receptor
  - OX Receptor
  - MT Receptor
  - GlyT
  - NMDAR
  - CaMK
  - Substance P
  - BACE
- NF-κB
  - HDAC
  - NF-κB
  - IκB/IKK
  - NOD1
- GPCR & G Protein
- Endocrinology & Hormones
- Transmembrane Transporters
  - Calcium Channel
  - Sodium Channel
  - ATPase
  - Chloride Channel
  - Potassium Channel
  - GABA Receptor
  - P-gp
  - Proton Pump
  - CFTR
  - TRPV
  - CRM1
  - OCT
  - Amino acid transporter
- Metabolism
  - PPAR
  - P450 (e.g. CYP17)
  - HSP e.g. HSP90
  - PDE
  - Hydroxylase
  - Factor Xa
  - DHFR
  - Dehydrogenase
  - Procollagen C Proteinase
  - Phospholipase (e.g. PLA)
  - Carbonic Anhydrase
  - MAO
  - Liver X Receptor
  - FAAH
  - Vitamin
  - IDO
  - PKM
  - Thioredoxin
  - FOX
  - Ferroptosis
  - Lipoxygenase
  - HMG-CoA Reductase
  - Lipase
  - Fatty Acid Synthase
  - NAMPT
  - LDL

研究领域