Carbonic Anhydrase
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1375 | Dorzolamide HCl | 14 mg/mL | <1 mg/mL | <1 mg/mL |
| S1438 | Topiramate | <1 mg/mL | 68 mg/mL | 68 mg/mL |
| S2866 | U-104 | <1 mg/mL | 62 mg/mL | <1 mg/mL |
| S2603 | Tioxolone | <1 mg/mL | 34 mg/mL | 34 mg/mL |
| S1736 | Methocarbamol | 2 mg/mL | 48 mg/mL | 48 mg/mL |
| S4998 | 2-Aminobenzenesulfonamide | -1 mg/mL | 34 mg/mL | -1 mg/mL |
| S2177 | Dichlorphenamide | <1 mg/mL | 61 mg/mL | 33 mg/mL |
| S3178 | Brinzolamide | <1 mg/mL | 77 mg/mL | <1 mg/mL |
| S4039 | Methazolamide | <1 mg/mL | 47 mg/mL | 3 mg/mL |
| S3697 | Mafenide hydrochloride | 44 mg/mL | 44 mg/mL | 8 mg/mL |
| S3647 | Mafenide Acetate | 49 mg/mL | 49 mg/mL | 3 mg/mL |
| S4506 | Acetazolamide | <1 mg/mL | 44 mg/mL | <1 mg/mL |
| S4725 | Benzenesulfonamide | <1 mg/mL | 31 mg/mL | 31 mg/mL |
特异性亚型抑制剂
- Carbonic Anhydrase抑制剂（13）
- 新Carbonic Anhydrase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1375 |
Dorzolamide HClDorzolamide HCl是一种水溶性的人类carbonic anhydrase II 和 IV抑制剂，其Ki 分别为1.9 nM和31 nM，用于治疗青光眼。 |
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| S1438 |
TopiramateTopiramate是一种多靶点的抑制剂，抑制了sodium channel 和 calcium channel, AMPA/kainate receptor以及carbonic anhydrase的活性，用于治疗癫痫。 |
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| S2866 |
U-104U-104是一种有效的碳酸酐酶(CA)抑制剂，作用于CA IX和CA XII，Ki分别为45.1 nM和4.5 nM，对CA I和CA II抑制活性弱。 |
Regression coefficients from the second-order stepwise linear regression model are provided based on the data obtained from Search 2.1 (B) The results allow the least effective compounds to be eliminated. Red is used to highlighted drug contributions that do not help to inhibit cell viability, orange bars are used to indicate minimal contributions and green highlights synergistic drug interactions. The inset in B shows the linear fit of modelled data with theoretical quartiles versus standardized residuals and the corresponding R2-values for each model. Significance is indicated by asterisks, **p < 0.01 and *p < 0.05.
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| S2603 |
TioxoloneTioxolone是一种金属酶碳酸酐酶I抑制剂，Ki为91 nM。 |
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| S1736 |
MethocarbamolMethocarbamol是碳酸酐酶抑制剂，用于治疗骨骼肌肉痉挛。 |
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| S4998New |
2-Aminobenzenesulfonamide2-Aminobenzenesulfonamide is an inhibitor of carbonic anhydrase IX. |
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| S2177 |
DichlorphenamideDichlorphenamide 是一种磺酰胺类碳酸酐酶抑制剂。 |
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| S3178 |
BrinzolamideBrinzolamide是一种强有效的碳酸酐酶–II抑制剂，IC50为3.19 nM。 |
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| S4039 |
MethazolamideMethazolamide是一种碳酸酐酶抑制剂，靶点有hCA I， hCA II和bCA IV亚型，Ki值分别为50 nM， 14 nM和36 nM。 |
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| S3697 |
Mafenide hydrochlorideMafenide是一种抑制碳酸酐酶的磺胺类药，用于局部抗感染、尤其是烧伤治疗中。 |
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| S3647 |
Mafenide AcetateMafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy. |
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| S4506 |
AcetazolamideAcetazolamide是一种有效的碳酸酐酶（CA）抑制剂。 |
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| S4725 |
BenzenesulfonamideBenzenesulfonamide是碳酸酐酶的抑制剂。 |
