HMG-CoA Reductase
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1792 | Simvastatin | <1 mg/mL | 83 mg/mL | 83 mg/mL |
| S2169 | Rosuvastatin Calcium | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S1759 | Pitavastatin Calcium | <1 mg/mL | 51 mg/mL | <1 mg/mL |
| S2061 | Lovastatin | <1 mg/mL | 8 mg/mL | 6 mg/mL |
| S1909 | Fluvastatin Sodium | 1 mg/mL | 87 mg/mL | <1 mg/mL |
| S5072 | Rosuvastatin | 96 mg/mL | 96 mg/mL | 23 mg/mL |
| S2077 | Atorvastatin Calcium | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S3036 | Pravastatin sodium | 89 mg/mL | 89 mg/mL | 12 mg/mL |
| S2664 | Clinofibrate | <1 mg/mL | 94 mg/mL | 94 mg/mL |
| S4223 | Mevastatin | <1 mg/mL | 78 mg/mL | <1 mg/mL |
| S8302 | SR-12813 | <1 mg/mL | 100 mg/mL | 100 mg/mL |
- HMG-CoA Reductase抑制剂（11）
- 新HMG-CoA Reductase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1792 |
SimvastatinSimvastatin 是一种HMG-CoA reductase竞争性抑制剂，无细胞试验中Ki为0.1-0.2 nM。 |
Statin-Related Inhibition of Dehydroepiandrosterone Sulfate (DHEAS) Uptake by SLCO2B1 in Prostate Cancer (PC) Cells. B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated. C, Uptake of DHEAS in PC cells before (scrambled short hairpin RNA) and after (short hairpin RNA 2B1) SLCO2B1 is knocked down when incubated with 2.5 μM DHEAS and 100 μM atorvastatin for 10 and 60 minutes. Statistical analysis was performed by comparing each condition with scrambled short hairpin RNA after 10 minutes with DHEAS except when indicated. P = .02 for the comparison between scrambled short hairpin RNA with 10 vs 60 minutes of DHEAS incubation for LNCaP and .01 for 22RV1. Other P values are indicated in the figure. Bars indicate means and error bars indicate standard deviation. |
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| S2169 |
Rosuvastatin CalciumRosuvastatin Calcium是一种竞争性HMG-CoA reductase抑制剂，无细胞试验中IC50为11 nM。 |
MDA-MB-231 cells were treated with simvastatin (SIM) or rosuvastatin (ROSU) in combination with ZOL for 48 h. Vitality and apoptosis were measured by using the cell titer blue and the caspase 3/7 Glo assay. Data are shown as mean ± SD of at least three individual experiments (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001). |
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| S1759 |
Pitavastatin CalciumPitavastatin Calcium，一种新型的Statins类药物，是pitavastatin的钙盐形式。Pitavastatin是高效的HMG-CoA reductase抑制剂。 |
Western blotting showed that in U87 cells treated with pitavastatin, the LC3-II isoform dramatically increased after statin treatment and showed at day 2, 3 and 4.
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| S2061 |
LovastatinLovastatin是一种HMG-CoA还原酶抑制剂，无细胞试验中IC50为3.4 nM，用于降胆固醇（降脂药）。 |
To evaluate the role of cell cycle progression in androgen induced DSB formation, LAPC4 cells were either treated with solvent control or 50 μM lovastatin for 36 h prior to stimulation with 100 nM DHT for 6 h. Note that androgen induced γH2A.X foci formation was not different between control and lovastatin pre-treated cells. |
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| S1909 |
Fluvastatin SodiumFluvastatin Sodium抑制HMG-CoA reductase活性，无细胞试验中IC50为8 nM。 |
The concentration of lanosterol slightly increases (f) and that of desmosterol significantly increases (g) in the brains of fluvastatin-treated 129.Mecp2tm1.1Bird/Y mice at P70 (n = 4 mice per group; P = 0.042). *P ≤ 0.05 determined using Dunnett’s post-hoc test to compare statin- with vehicle-treated groups. All error bars represent the s.e.m. |
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| S5072New |
RosuvastatinRosuvastatin is an inhibitor of HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, with Ki value (inhibition constant) of approximately 0.1 nM. |
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| S2077 |
Atorvastatin CalciumAtorvastatin Calcium 是一种HMG-CoA reductase抑制剂，用作降胆固醇药物，并阻断胆固醇的产生。 |
Micrographs of hematoxylin and eosin-stained liver sections from untreated and atorvastatin-treated TO mouse. Results of representative experiment of liver specimens incubated in vitro at 37癈 with and without 1.0 礛 atorvastatin for 6 hr is shown. A liver specimen at 0 hr is also shown. Liver structure and cytology are preserved in treated and untreated specimens. Inflammation and cholestasis are absent. (Hematoxylin and eosin, 10?and 40?. |
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| S3036 |
Pravastatin sodiumPravastatin sodium是一种HMG-CoA还原酶抑制剂，能抑制甾醇合成，其IC50为5.6 μM。 |
B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated. |
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| S2664 |
ClinofibrateClinofibrate抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM，是一种降脂剂，用于控制血液中的高胆固醇和甘油三酯水平。 |
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| S4223 |
MevastatinMevastatin 是竞争性HMG辅酶A（HMG-COA）还原酶抑制剂，比HMG-CoA底物本身结合亲合力高10,000倍。 |
SAHA and Statins on the proliferation of TNBC cells. TNBC or MCF-10A cells were treated with (D) Mevastatin, (E) Mevastatin + 0.5 μmol/l SAHA. Except for that a final concentration of 0.5 μmol/l SAHA was used in combination groups, serial 2-fold dilutions of each compound in a final concentration range of 32–0.03 μmol/l were used in experiments. Cell counting was assessed by using CCK8 reagent at 72 h after treatments. Dose-response curves were plotted as concentration (logarithmic scale) versus normalized response-variable slope using non-linear regression by software Prism 5.0 (Graphpad). Experiments were performed in triplicate, and data were presented as the mean±S.E.M.
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| S8302 |
SR-12813SR-12813是孕烷X受体（PXR）的激动剂。 |
