HMG-CoA Reductase
信号通路图
研究领域
抑制剂选择性比较
HMG-CoA Reductase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1792 |
SimvastatinSimvastatin 是一种HMG-CoA reductase竞争性抑制剂，无细胞试验中Ki为0.1-0.2 nM。 |
Pharmacological inhibition of HMGR by simvastatin (250 nM) for 72 h, atorvastatin (10 μM) for 48 h or pitavastatin (1 μM) for 72 h. ***P<0.001; **P<0.01. Error bars = Mean ± SEM (n=3).
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| S2169 |
Rosuvastatin CalciumRosuvastatin Calcium是一种竞争性HMG-CoA reductase抑制剂，无细胞试验中IC50为11 nM。 |
MDA-MB-231 cells were treated with simvastatin (SIM) or rosuvastatin (ROSU) in combination with ZOL for 48 h. Vitality and apoptosis were measured by using the cell titer blue and the caspase 3/7 Glo assay. Data are shown as mean ± SD of at least three individual experiments (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001). |
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| S1759 |
Pitavastatin CalciumPitavastatin Calcium，一种新型的Statins类药物，是pitavastatin的钙盐形式。Pitavastatin是高效的HMG-CoA reductase抑制剂。 |
Western blotting showed that in U87 cells treated with pitavastatin, the LC3-II isoform dramatically increased after statin treatment and showed at day 2, 3 and 4.
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| S2061 |
LovastatinLovastatin是一种HMG-CoA还原酶抑制剂，无细胞试验中IC50为3.4 nM，用于降胆固醇（降脂药）。 |
To evaluate the role of cell cycle progression in androgen induced DSB formation, LAPC4 cells were either treated with solvent control or 50 μM lovastatin for 36 h prior to stimulation with 100 nM DHT for 6 h. Note that androgen induced γH2A.X foci formation was not different between control and lovastatin pre-treated cells. |
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| S1909 |
Fluvastatin SodiumFluvastatin Sodium抑制HMG-CoA reductase活性，无细胞试验中IC50为8 nM。 |
The concentration of lanosterol slightly increases (f) and that of desmosterol significantly increases (g) in the brains of fluvastatin-treated 129.Mecp2tm1.1Bird/Y mice at P70 (n = 4 mice per group; P = 0.042). *P ≤ 0.05 determined using Dunnett’s post-hoc test to compare statin- with vehicle-treated groups. All error bars represent the s.e.m. |
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| S5715New |
atorvastatinAtorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. |
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| S5713New |
PravastatinPravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. |
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| S5072New |
RosuvastatinRosuvastatin is an inhibitor of HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, with Ki value (inhibition constant) of approximately 0.1 nM. |
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| S2077 |
Atorvastatin CalciumAtorvastatin Calcium 是一种HMG-CoA reductase抑制剂，用作降胆固醇药物，并阻断胆固醇的产生。 |
Micrographs of hematoxylin and eosin-stained liver sections from untreated and atorvastatin-treated TO mouse. Results of representative experiment of liver specimens incubated in vitro at 37癈 with and without 1.0 礛 atorvastatin for 6 hr is shown. A liver specimen at 0 hr is also shown. Liver structure and cytology are preserved in treated and untreated specimens. Inflammation and cholestasis are absent. (Hematoxylin and eosin, 10?and 40?. |
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| S3036 |
Pravastatin sodiumPravastatin sodium是一种HMG-CoA还原酶抑制剂，能抑制甾醇合成，其IC50为5.6 μM。 |
B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated. |
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| S2664 |
ClinofibrateClinofibrate抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM，是一种降脂剂，用于控制血液中的高胆固醇和甘油三酯水平。 |
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| S4223 |
MevastatinMevastatin 是竞争性HMG辅酶A（HMG-COA）还原酶抑制剂，比HMG-CoA底物本身结合亲合力高10,000倍。 |
Sterol-starved HepG2 cells were treated with vehicle or mevastatin for 24 h before exposure to the indicated concentrations of MK-2206 for a further 14 h. Cells were then harvested and subjected to Western blot analysis. Upper panel shows one representative blot from six experiments. Lower panel: the immunoblots data were plotted relative to vehicle-treated cells. Error bars represent SD. One, two and three asterisks indicate p < 0.05, p < 0.01 and p < 0.001, respectively, compared with matched vehicle-treated cells.
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| S8302 |
SR-12813SR-12813是孕烷X受体（PXR）的激动剂。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1792 |
SimvastatinSimvastatin 是一种HMG-CoA reductase竞争性抑制剂，无细胞试验中Ki为0.1-0.2 nM。 |
Pharmacological inhibition of HMGR by simvastatin (250 nM) for 72 h, atorvastatin (10 μM) for 48 h or pitavastatin (1 μM) for 72 h. ***P<0.001; **P<0.01. Error bars = Mean ± SEM (n=3).
|
|
| S2169 |
Rosuvastatin CalciumRosuvastatin Calcium是一种竞争性HMG-CoA reductase抑制剂，无细胞试验中IC50为11 nM。 |
MDA-MB-231 cells were treated with simvastatin (SIM) or rosuvastatin (ROSU) in combination with ZOL for 48 h. Vitality and apoptosis were measured by using the cell titer blue and the caspase 3/7 Glo assay. Data are shown as mean ± SD of at least three individual experiments (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001). |
|
| S1759 |
Pitavastatin CalciumPitavastatin Calcium，一种新型的Statins类药物，是pitavastatin的钙盐形式。Pitavastatin是高效的HMG-CoA reductase抑制剂。 |
Western blotting showed that in U87 cells treated with pitavastatin, the LC3-II isoform dramatically increased after statin treatment and showed at day 2, 3 and 4.
|
|
| S2061 |
LovastatinLovastatin是一种HMG-CoA还原酶抑制剂，无细胞试验中IC50为3.4 nM，用于降胆固醇（降脂药）。 |
To evaluate the role of cell cycle progression in androgen induced DSB formation, LAPC4 cells were either treated with solvent control or 50 μM lovastatin for 36 h prior to stimulation with 100 nM DHT for 6 h. Note that androgen induced γH2A.X foci formation was not different between control and lovastatin pre-treated cells. |
|
| S1909 |
Fluvastatin SodiumFluvastatin Sodium抑制HMG-CoA reductase活性，无细胞试验中IC50为8 nM。 |
The concentration of lanosterol slightly increases (f) and that of desmosterol significantly increases (g) in the brains of fluvastatin-treated 129.Mecp2tm1.1Bird/Y mice at P70 (n = 4 mice per group; P = 0.042). *P ≤ 0.05 determined using Dunnett’s post-hoc test to compare statin- with vehicle-treated groups. All error bars represent the s.e.m. |
|
| S5715New |
atorvastatinAtorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. |
||
| S5713New |
PravastatinPravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. |
||
| S5072New |
RosuvastatinRosuvastatin is an inhibitor of HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, with Ki value (inhibition constant) of approximately 0.1 nM. |
||
| S2077 |
Atorvastatin CalciumAtorvastatin Calcium 是一种HMG-CoA reductase抑制剂，用作降胆固醇药物，并阻断胆固醇的产生。 |
Micrographs of hematoxylin and eosin-stained liver sections from untreated and atorvastatin-treated TO mouse. Results of representative experiment of liver specimens incubated in vitro at 37癈 with and without 1.0 礛 atorvastatin for 6 hr is shown. A liver specimen at 0 hr is also shown. Liver structure and cytology are preserved in treated and untreated specimens. Inflammation and cholestasis are absent. (Hematoxylin and eosin, 10?and 40?. |
|
| S3036 |
Pravastatin sodiumPravastatin sodium是一种HMG-CoA还原酶抑制剂，能抑制甾醇合成，其IC50为5.6 μM。 |
B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated. |
|
| S2664 |
ClinofibrateClinofibrate抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM，是一种降脂剂，用于控制血液中的高胆固醇和甘油三酯水平。 |
||
| S4223 |
MevastatinMevastatin 是竞争性HMG辅酶A（HMG-COA）还原酶抑制剂，比HMG-CoA底物本身结合亲合力高10,000倍。 |
Sterol-starved HepG2 cells were treated with vehicle or mevastatin for 24 h before exposure to the indicated concentrations of MK-2206 for a further 14 h. Cells were then harvested and subjected to Western blot analysis. Upper panel shows one representative blot from six experiments. Lower panel: the immunoblots data were plotted relative to vehicle-treated cells. Error bars represent SD. One, two and three asterisks indicate p < 0.05, p < 0.01 and p < 0.001, respectively, compared with matched vehicle-treated cells.
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| S8302 |
SR-12813SR-12813是孕烷X受体（PXR）的激动剂。 |
