Integrin
信号通路图
研究领域
抑制剂选择性比较
Integrin产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7077 |
Cilengitide trifluoroacetateCilengitide是一种有效的integrin抑制剂，作用于αvβ3受体和αvβ5受体，无细胞试验中IC50分别为4.1 nM和79 nM，比作用于gpIIbIIIa选择性高10倍左右。Phase 2。 |
Cell growth inhibition of non-small cell lung carcinoma (NSCLC) by Cilengitide. Cilengitide is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins. Interestingly, it acts differently on HTB183 and A549 cell lines. Cilengitide was more efficient on A549, lung adenocarcinoma, while in HTB183 it showed moderate inhibitory activity. This may be due to the mestastatic nature of HTB183 cells which have already lost the cell adhesion properties.
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| S8008 |
RGD (Arg-Gly-Asp) PeptidesRGD (Arg-Gly-Asp) Peptides是一种细胞粘附序列，可以模仿细胞粘附蛋白并与整合素结合。 |
Observation of actin cytoskeleton and nucleus of MC3T3-E1 cells cultured in the presence of different inhibitors (Control, EDTA, RGD, MAB1998, IgG and Heparin) after 24 hours of incubation.
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| S2885 |
A-205804A-205804是一种强有效和选择性E-selectin和ICAM-1表达抑制剂， IC50分别为20 nM和25 nM。 |
The effect of rhICAM-1 or inhibitor A-205804 on hepsin or CtsD transfected MCF-7 cells was detected. The level of E-cadherin, claudin-1, N-cadherin, vimentin and Snail1 was analyzed by western blot.
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| S7540 |
SB273005SB273005 是一种有效的integrin抑制剂，对αvβ3 受体和αvβ5受体的Ki分别为1.2 nM 和 0.3 nM。 |
Western blot analysis of levels of p-FAK (Tyr397) and total FAK in SK-N-SH cells treated with SB273005 (3 μM) for 6 h and 24 h. One experiment is shown for each cell line. Control cells (treated with diluent, marked as C, were also included). α-tubulin was used as the reference protein.
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| S7834 |
Cyclo (-RGDfK)Cyclo(-RGDfK)是一种有效的选择性 αvβ3 integrin 抑制剂。 |
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| S7844 |
Cyclo(RGDyK)Cyclo(RGDyK)是一种有效的选择性αVβ3 integrin抑制剂，IC50为20 nM。 |
(E, F) Inhibition of integrin pathway by integrin inhibitor Cyclo(RGDyK) (30 µM) eliminated the enhancement of ZC3H14 depletion on integrin pathway in HepG2 (E) and MHCC-97L (F) cells. NS, non-specific reactive band.
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| S3085 |
TirofibanTirofiban是一种选择性GPIIb/IIIa拮抗剂，可以抑制血小板聚集，IC50为9nM。 |
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| S8594 |
Tirofiban HydrochlorideTirofiban Hydrochloride是tirofiban的盐酸盐形式，tirofiban是一种选择性的platelet GPIIb/IIIa拮抗剂，抑制血小板凝集。它比游离形式的Tirofiban溶解性更好。 |
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| S8454 |
ATN-161 (Ac-PHSCN-NH2)ATN-161 (Ac-PHSCN-NH2)是integrin α5β1的小肽段拮抗剂。它能够结合好几种整合素，包括α5β1和αvβ3，在血管生成和肿瘤进展中发挥作用。 |
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| S3714 |
LifitegrastLifitegrast是一种新型的integrin拮抗剂，抑制参与DED病理形成中的特定的T细胞介导的炎症途径。 |
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| S8306 |
Leukadherin-1Leukadherin-1 (LA1)是一种能增强CD11b/CD18依赖性的细胞与其配体ICAM-1粘着的小分子化合物，是补体受体3（CD11b/CD18）的激动剂。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7077 |
Cilengitide trifluoroacetateCilengitide是一种有效的integrin抑制剂，作用于αvβ3受体和αvβ5受体，无细胞试验中IC50分别为4.1 nM和79 nM，比作用于gpIIbIIIa选择性高10倍左右。Phase 2。 |
Cell growth inhibition of non-small cell lung carcinoma (NSCLC) by Cilengitide. Cilengitide is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins. Interestingly, it acts differently on HTB183 and A549 cell lines. Cilengitide was more efficient on A549, lung adenocarcinoma, while in HTB183 it showed moderate inhibitory activity. This may be due to the mestastatic nature of HTB183 cells which have already lost the cell adhesion properties.
|
|
| S8008 |
RGD (Arg-Gly-Asp) PeptidesRGD (Arg-Gly-Asp) Peptides是一种细胞粘附序列，可以模仿细胞粘附蛋白并与整合素结合。 |
Observation of actin cytoskeleton and nucleus of MC3T3-E1 cells cultured in the presence of different inhibitors (Control, EDTA, RGD, MAB1998, IgG and Heparin) after 24 hours of incubation.
|
|
| S2885 |
A-205804A-205804是一种强有效和选择性E-selectin和ICAM-1表达抑制剂， IC50分别为20 nM和25 nM。 |
The effect of rhICAM-1 or inhibitor A-205804 on hepsin or CtsD transfected MCF-7 cells was detected. The level of E-cadherin, claudin-1, N-cadherin, vimentin and Snail1 was analyzed by western blot.
|
|
| S7540 |
SB273005SB273005 是一种有效的integrin抑制剂，对αvβ3 受体和αvβ5受体的Ki分别为1.2 nM 和 0.3 nM。 |
Western blot analysis of levels of p-FAK (Tyr397) and total FAK in SK-N-SH cells treated with SB273005 (3 μM) for 6 h and 24 h. One experiment is shown for each cell line. Control cells (treated with diluent, marked as C, were also included). α-tubulin was used as the reference protein.
|
|
| S7834 |
Cyclo (-RGDfK)Cyclo(-RGDfK)是一种有效的选择性 αvβ3 integrin 抑制剂。 |
||
| S7844 |
Cyclo(RGDyK)Cyclo(RGDyK)是一种有效的选择性αVβ3 integrin抑制剂，IC50为20 nM。 |
(E, F) Inhibition of integrin pathway by integrin inhibitor Cyclo(RGDyK) (30 µM) eliminated the enhancement of ZC3H14 depletion on integrin pathway in HepG2 (E) and MHCC-97L (F) cells. NS, non-specific reactive band.
|
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S3085 |
TirofibanTirofiban是一种选择性GPIIb/IIIa拮抗剂，可以抑制血小板聚集，IC50为9nM。 |
||
| S8594 |
Tirofiban HydrochlorideTirofiban Hydrochloride是tirofiban的盐酸盐形式，tirofiban是一种选择性的platelet GPIIb/IIIa拮抗剂，抑制血小板凝集。它比游离形式的Tirofiban溶解性更好。 |
||
| S8454 |
ATN-161 (Ac-PHSCN-NH2)ATN-161 (Ac-PHSCN-NH2)是integrin α5β1的小肽段拮抗剂。它能够结合好几种整合素，包括α5β1和αvβ3，在血管生成和肿瘤进展中发挥作用。 |
||
| S3714 |
LifitegrastLifitegrast是一种新型的integrin拮抗剂，抑制参与DED病理形成中的特定的T细胞介导的炎症途径。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S8306 |
Leukadherin-1Leukadherin-1 (LA1)是一种能增强CD11b/CD18依赖性的细胞与其配体ICAM-1粘着的小分子化合物，是补体受体3（CD11b/CD18）的激动剂。 |
