Integrin
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7077 | Cilengitide trifluoroacetate | 8 mg/mL | 100 mg/mL | <1 mg/mL |
| S8008 | RGD (Arg-Gly-Asp) Peptides | 12 mg/mL | <1 mg/mL | <1 mg/mL |
| S2885 | A-205804 | <1 mg/mL | 60 mg/mL | <1 mg/mL |
| S7540 | SB273005 | <1 mg/mL | 90 mg/mL | 16 mg/mL |
| S7834 | Cyclo (-RGDfK) | 84 mg/mL | 100 mg/mL | <1 mg/mL |
| S7844 | Cyclo(RGDyK) | 100 mg/mL | 100 mg/mL | 20 mg/mL |
| S3085 | Tirofiban | <1 mg/mL | 0.005 mg/mL | <1 mg/mL |
| S8594 | Tirofiban Hydrochloride | 95 mg/mL | 95 mg/mL | 95 mg/mL |
| S8454 | ATN-161 (Ac-PHSCN-NH2) | 13 mg/mL | -1 mg/mL | -1 mg/mL |
| S3714 | Lifitegrast | <1 mg/mL | 100 mg/mL | 20 mg/mL |
| S8306 | Leukadherin-1 | <1 mg/mL | 15 mg/mL | <1 mg/mL |
- Integrin抑制剂（11）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7077 |
Cilengitide trifluoroacetateCilengitide是一种有效的integrin抑制剂，作用于αvβ3受体和αvβ5受体，无细胞试验中IC50分别为4.1 nM和79 nM，比作用于gpIIbIIIa选择性高10倍左右。Phase 2。 |
WT mice were subjected to BDL and treated with either vehicle or cilengitide (10 mg/kg) daily for 6 days; adjacent liver sections were immunostained for CK19 or PCNA. Data were quantified and expressed as mean ± SD. (n = 6 per group.) *P < 0.02, **P < 0.004, Student’s t test.
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| S8008 |
RGD (Arg-Gly-Asp) PeptidesRGD (Arg-Gly-Asp) Peptides是一种细胞粘附序列，可以模仿细胞粘附蛋白并与整合素结合。 |
BC, aMPV/B F protein fusogenic activity was determined using syncytium formation and reporter gene assays. RGE peptides (80 μM) were used as the control.
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| S2885 |
A-205804A-205804是一种强有效和选择性E-selectin和ICAM-1表达抑制剂， IC50分别为20 nM和25 nM。 |
MDA-MB-231 cells transfected with ICAM-1-specific siRNAs or treated for 12 h with A-205804 at the indicated concentrations were subjected to immunoblotting with indicated antibodies. Densitometric data (fold) were shown below each group.
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| S7540 |
SB273005SB273005 是一种有效的integrin抑制剂，对αvβ3 受体和αvβ5受体的Ki分别为1.2 nM 和 0.3 nM。 |
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| S7834 |
Cyclo (-RGDfK)Cyclo(-RGDfK)是一种有效的选择性 αvβ3 integrin 抑制剂。 |
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| S7844 |
Cyclo(RGDyK)Cyclo(RGDyK)是一种有效的选择性αVβ3 integrin抑制剂，IC50为20 nM。 |
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| S3085 |
TirofibanTirofiban是一种选择性GPIIb/IIIa拮抗剂，可以抑制血小板聚集，IC50为9nM。 |
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| S8594 |
Tirofiban HydrochlorideTirofiban Hydrochloride是tirofiban的盐酸盐形式，tirofiban是一种选择性的platelet GPIIb/IIIa拮抗剂，抑制血小板凝集。它比游离形式的Tirofiban溶解性更好。 |
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| S8454 |
ATN-161 (Ac-PHSCN-NH2)ATN-161 (Ac-PHSCN-NH2)是integrin α5β1的小肽段拮抗剂。它能够结合好几种整合素，包括α5β1和αvβ3，在血管生成和肿瘤进展中发挥作用。 |
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| S3714 |
LifitegrastLifitegrast是一种新型的integrin拮抗剂，抑制参与DED病理形成中的特定的T细胞介导的炎症途径。 |
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| S8306 |
Leukadherin-1Leukadherin-1 (LA1)是一种能增强CD11b/CD18依赖性的细胞与其配体ICAM-1粘着的小分子化合物，是补体受体3（CD11b/CD18）的激动剂。 |
