4-Hydroxytamoxifen (Afimoxifene)

For research use only. Not for use in humans.

目录号:S7827 别名: Afimoxifene 中文名称:4-羟基三苯氧胺

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1057.45 现货
RMB 958.6 现货
RMB 4070.46 现货
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客户使用Selleck生产的4-Hydroxytamoxifen (Afimoxifene)发表文献9篇:

客户使用该产品的1个实验数据:

  • CDK4/6 inhibitor resistance promotes diminished ER expression and activity. (a and b) Proliferation of MCF-7 and MR cells in the presence of different concentrations of ICI (a) or 4-hydroxytamoxifen (4-OHT) (b) was measured by the alamarBlue assay and plotted as % inhibition of proliferation against log concentration of inhibitor. Each data point represents the average value±s.d. of six replicates obtained in three independent experiments.

    Oncogene, 2016, 36(16):2255-2264. 4-Hydroxytamoxifen (Afimoxifene) purchased from Selleck.

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

生物活性

产品描述 4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。
体外研究

4-OHT是有效的ER激活剂,相比于tamoxifen,它对雌激素受体有更高的亲和力。4-OHT具有较强的剂量和时间依赖式效应,能改变分离出来的大鼠心肌细胞的收缩功能[1]。4-HT可激活intein-Cas9突变体的靶向修饰效率[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NFTTV5NRem:uaX\ldoF1cW:wIHHzd4F6 M4Gyc2lvcGmkaYTpc44hd2ZiZYP0do9o\W5vc4TpcZVt[XSnZDDNR2YuPyClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC53IH7N MnP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTV2OEixO{c,QTV2OEixO|ww[T5?
MCF7 MlXFSpVv[3Srb36gZZN{[Xl? NXO0cHIxTW[oZXP0bZZmKGSxc3Wg[o9zKFt|SG2tJIV{fHKjZHnvcEBi\2GrboP0JJBzd2yrZnXyZZRqd25ib3[gUWNHNTdiY3XscJMtKEWFNUCgQUAxNjByMECzJO69VS5? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ7NkixK|4zPzZ7NkixQE9iRg>?
MCF7 MYnGeY5kfGmxbjDhd5NigQ>? NVT3TY5zPCCqcoO= MYTJcoR2[3Srb36gc4YhTVKjbIDoZUBl\We{YXTheIlwdiCrbjDoeY1idiCPQ1[3JINmdGy|IHnuJJBp\W6xbDDy[YQh\nKnZTDSVG1KKG2nZHn1cUBkd262YXnubY5oKDVnIHPoZZJkd2GuIHTlfJRz[W5vdILlZZRm\CCIQmOgbY5kfWKjdHXkJIZweiB2IHjyd{BjgSCVUEGgZY5lKGGwdHmtSXIhemGkYnn0JI1wdm:lb3zuZYwh[W62aXLv[Jkh[mG|ZXSgbY4u[2WubDDX[ZN1\XKwIHHzd4F6NCCDY4Tpeol1gSB;IECuNFAxOSEQvF2u NWq1Ro43RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPFY3OjZpPkOwNFg3PjJ4PD;hQi=>
MCF7 MkXWSpVv[3Srb36gZZN{[Xl? MoLtSYZn\WO2aY\lJINwdmOnboTyZZRqd25iYXfhbY5{fCCPQ1[tO{BjemWjc4SgeJVud3JiY3XscJMhfXOrbnegUWNHNTdiYYPzZZktKEWFNUCgQUAxNjByMEGyJO69VS5? M2XleFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEK1PVM2Lz5zMkiyOVk{PTxxYU6=
MCF7 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MkPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wNFA2KM7:TT6= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyNUK4Okc,OjJ2MEWyPFY9N2F-
MCF7 NXHBNJVpSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNuIFnDOVAhRSByLkCwNFU{PyEQvF2u NIP6Tog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|AyOid-Mk[0NFcxOTJ:L3G+
MCF MkPnSpVv[3Srb36gZZN{[Xl? NIXWTYJCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IIDyc4dme3Sncn;u[UBz\WOncITvdkBqdiCqdX3hckBOS0ZiY3XscJMh[XO|ZYPz[YQh[XNiZYP0doFlcW:uLXnu[JVk\WRicnXj[ZB1d3JicnXzdI9ve2VuIFnDOVAhRSByLkCwNFc6PDNizszNMi=> Ml\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEewNVIoRjJ4NEC3NFEzRC:jPh?=
Ishikawa endometrial cells MlvXSpVv[3Srb36gZZN{[Xl? NEnXSnFC\2:waYP0JIFkfGm4aYT5JIF{KGGua3HsbY5mKHCqb4PwbIF1[XOnIHnu[JVkfGmxbjDpckBKe2ira3H3ZUBmdmSxbXX0dolidCClZXzsd{Bkd22yYYLl[EB1dyCHMjygSWM2OCB;IECuNFAxQCEQvF2u M4m0fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3M{iwNlA5Lz5zNUO4NFIxQDxxYU6=
MCF7 M3LlcmZ2dmO2aX;uJIF{e2G7 Mle0TY5pcWKrdHnvckBw\iCnc4Tyc4dmdi2rbnT1Z4VlKHC{b3zp[oVz[XSrb36gbY4hcHWvYX6gUWNHNTdiYoLlZZN1KGOjbnPldkBk\WyuczygTWM2OCB;IECuNFAyOTdizszNMi=> NY\zXVZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUG1OFk3Oyd-OUG1OFk3OzxxYU6=
MCF7 NF3oWGFHfW6ldHnvckBie3OjeR?= M4OwZ|I1KGi{cx?= NV;WN24ySW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoFteGijIHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDld5Rzd2enbj3pcoR2[2WmIITyZY5{[3KrcITpc44heHKnaX7jeYJifGWmIH;2[ZJvcWeqdDDmc4xtd3enZDDifUBme3S{b3flckBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomg[JVidCCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlAxOyEQvF2u NIHGfHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK5OlM6QCd-MkiyPVY{QTh:L3G+
Rosetta 2 DE3 NULreoRvTnWwY4Tpc44h[XO|YYm= NXXPdlhtOSCqch?= M2nWNWRqe3CuYXPlcYVvfCCxZjDbN2heNWW|dILh[IlwdCCocn;tJJJm[2:vYnnuZY51KGi3bXHuJG4ufGW{bXnuZYwhUGm|LYTh[4dm\CCHUnHsdIhiKEyERDDoZZJjd3KrbnegR|M5OVNxQ{SxO3MwSzV|MGOgcZV1[W62IHX4dJJme3OnZDDpckBTd3OndIThJFIhTEV|IHPvcZBmfGWwdDDj[YxteyCjZoTldkAyKGi{IHL5JHNRSSCkaX7kbY5oKGG|c3H5MEBKSzVyIE2gNE4xODRizszNMi=> NXf4SY5qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPVY{QThpPkK4Nlk3Ozl6PD;hQi=>
insect cells Mn\zSpVv[3Srb36gZZN{[Xl? MoLLTY5pcWKrdHnvckBw\iCobIXvdo1wdmViRWOyJIdz\WWwIHLpcoRqdmdidH:gdoVkd22kaX7hcpQh\nWubDDs[Y5ofGhiaIXtZY4hTVKjbIDoZUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIJ6KG[udX;y[ZNk\W6lZTDwc4xiemm8YYTpc44h[XO|YYmsJGlEPTBiPTCwMlAxPjJ7IN88UU4> MmqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5M{WyNVQoRjJ6N{O1NlE1RC:jPh?=
MCF-7-2a M2j3XWZ2dmO2aX;uJIF{e2G7 MXjJcohq[mm2aX;uJI9nKGW|dILh[IlwdCCrbnT1Z4VlKGW|dILv[4VvKHKnY3XweI9zKHS{YX7zZ5JqeHSrb37hcEBi[3SrdnH0bY9vKGmwIF3DSk04NTKjIHPlcIx{NCCLQ{WwJF0hOC5yMEeg{txONg>? MmXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4N{KyOFkoRjF{NkeyNlQ6RC:jPh?=
MCF7 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUL1dlJVOjRiaILz MnfwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSByLkCwPFUh|ryPLh?= M3O0eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkeyNlU3Lz5zOEK3NlI2PjxxYU6=
MCF7 NH64dYdHfW6ldHnvckBie3OjeR?= MVjJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCPQ1[tO{BjemWjc4SgeJVud3JiY3XscJMhfXOrbnegUWNHNTdiYYPzZZktKEmFNUCgQUAxNjByOEWg{txONg>? MnL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
Ishikawa cells NYfjfllvTnWwY4Tpc44h[XO|YYm= NULUNmZJPzJiaILz M1;HPWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiZYP0do9o\W5icnXj[ZB1d3JiYXzwbIEw[mW2YTDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WytYXzpcoUheGixc4DoZZRie2ViYYPzZZktKEmFNUCgQUAxNjBzIN88UU4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{NkmzNUc,Ojh2Mk[5N|E9N2F-
insect cells M4n5OGZ2dmO2aX;uJIF{e2G7 NXXIWVBnTGm|cHzhZ4Vu\W62IH;mJIZtfW:{ZYPj[YlvKGyjYnXs[YQh\XO2cnHkbY9tKG[{b32gbJVu[W5icnXjc41jcW6jboSgSXJj\XSjIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCrboPlZ5Qh[2WubIOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OCB;IECuNFIh|ryPLh?= M2e2flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OEO1NVc3Lz5zOEizOVE4PjxxYU6=
MCF7 NHLNNXVEgXSxdH;4bYNqfHliYYPzZZk> MYq1JIRigXN? NFrVXG1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFUh\GG7czygTWM2OCB;IECuNFI6OSEQvF2u M1;MTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OE[0PVI5Lz5{M{i2OFkzQDxxYU6=
GT1-7 Mlu0SpVv[3Srb36gZZN{[Xl? NIDSNYozOCC2bzCyOEBpenN? NXrYWJZQSW62YXfvcol{fCCjY4Tpeol1gSCjdDDld5Rzd2enbjDy[YNmeHSxcjDpckBud3W|ZTDHWFEuPyClZXzsd{Bp[XKkb4Lpcoch[mW2YT3nZYxi[3Sxc3nkZZNmKHKncH;yeIVzKGenbnWgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIEG3ZoV1[S2nc4TyZYRqd2xiaX7keYNm\CC{ZYPwc45{\SCvZXHzeZJm\CCjZoTldkAzOCC2bzCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwJF0hOC5yM{OyJO69VS5? NXPx[HBiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NFAzOzlpPkK4OFAxOjN7PD;hQi=>
insect cells M{PiTmZ2dmO2aX;uJIF{e2G7 Mkf4SIl{eGyjY3Xt[Y51KG:oIH\seY9z\XOlZXnuJIxi[mWuZXSg[ZN1emGmaX;sJIZzd21iaIXtZY4hemWlb33ibY5idnRiRWLhcJBp[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhcW6|ZXP0JINmdGy|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkC0JO69VS5? M37melxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OEO1NVc3Lz5zOEizOVE4PjxxYU6=
HEK293 NIWyeHZHfW6ldHnvckBie3OjeR?= MnnNN|AhdWmwcx?= MoH4TY5pcWKrdHnvckBw\iCJRmCteIFo\2WmIHj1cYFvKFCOREKg[ZhxemW|c3XkJIlvKGi3bXHuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBxcG:|cHjheIllgWykdYThco9tNVumOW2gdJJw\HWldHnvckBi\nSncjCzNEBucW6|IHL5JI1ie3Nic4DlZ5Rzd22ndILpZ{BidmGueYPpd{whUUN3MDC9JFAvODR2IN88UU4> NHr4TJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGzOlk4PSd-MUmxN|Y6PzV:L3G+
HEK293 MonXSpVv[3Srb36gZZN{[Xl? M{fNe|EhcHJ? NFrFNohCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IILlZ49u[mmwYX70JIh2dWGwIFXSZYxxcGFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILh[IlwdC2rbnT1Z4VlKFmIUD3meZNm\CCVUlOxJINw[WO2aY\heI9zKHKnY4L1bZRu\W62IH3lZZN2emWmIHHmeIVzKDFiaIKgbY4heHKnc3XuZ4Uhd2ZiQ3;lcIVvfGW{YYrpcoUhUCCkeTDCVmVVKGG|c3H5MEBKSzVyIE2gNE4xPyEQvF2u MkPsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NXv4eZl{PzJiaILz MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHXzeJJw\2WwIILlZ4VxfG:{IHTldIVv\GWwdDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkGwO{DPxE1w MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh|NUG3Okc,OTh6M{WxO|Y9N2F-
MCF7 MknZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWHmUHgxPzJiaILz MlzSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSC2conwZY4h[my3ZTDhd5NigSxiR1m1NEA:KDBwMUC3JO69VS5? NFLkcW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ezOVgzQSd-MkO3N|U5Ojl:L3G+
MCF7 M3:5NmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1T3blczKGi{cx?= M37IWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSXIu\GWyZX7k[Y51KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOTFizszNMi=> NUjPeJFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlY6OzFpPkK4OFI3QTNzPD;hQi=>
T47D NX\BXok5S3m2b4TvfIlkcXS7IHHzd4F6 MUi1JIRigXN? MmnxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFQ4TCClZXzsd{Bi\nSncjC1JIRigXNuIFnDOVAhRSByLkKxJO69VS5? NHzSUI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i2OFkzQCd-MkO4OlQ6Ojh:L3G+
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MCF7 NFfsTJlCdnSrY3HuZ4VzKGG|c3H5 NYTNfGgyOjVyIITvJFUxOCCwTR?= NVrOT3RvPSCmYYnz NYrhVmlGSW62aXPhcoNmeiCjZ3HpcpN1KGi3bXHuJGVTNXCxc3n0bZZmKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCnc4TyZYRqd2xvaX7keYNm\CClZXzsJJBzd2yrZnXyZZRqd25iYYSgNlUxKHSxIEWwNEBvVSCjZoTldkA2KGSjeYO= NFra[mM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm0OlE1PSd-MkS5OFYyPDV:L3G+
MCF7 M{SzW2Z2dmO2aX;uJIF{e2G7 NHjqPYU2KHWP MVKyOEBpenN? NH;ITVJCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDNXWMhdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= NIXydoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 M2fhUmZ2dmO2aX;uJIF{e2G7 NYmyVZlUPSC3TR?= MUmyOEBpenN? NHfBZoJCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDUSmYyKG2UTlGg[ZhxemW|c3nvckBifCB3IIXNJIFnfGW{IEK0JIhzeyCkeTDRTWF7d2xicnXh[4VvfCCkYYPl[EBTXC2zUFPSJIFv[Wy7c3nz Ml3CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 NXS1cphnTnWwY4Tpc44h[XO|YYm= MVe1JJVO NGn6NWszPCCqcoO= NWrjdZpFSW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoFteGijIHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhe3WycILld5Nqd25ib3[gS3JGSjFibWLORUBmgHC{ZYPzbY9vKGG2IEWgeW0h[W[2ZYKgNlQhcHK|IHL5JHFKSXqxbDDy[YFo\W62IHLhd4VlKFKWLYHQR3Ih[W6jbInzbZM> M2SxfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 NHe5doNHfW6ldHnvckBie3OjeR?= MmjTOUB2VQ>? M4DvTVI1KGi{cx?= NIW0c2pCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDNXWJNOiCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5OE[wPUc,OzByN{i2NFk9N2F-
MCF7 Mn\wSpVv[3Srb36gZZN{[Xl? MmfBOUB2VQ>? NF3TZpIzPCCqcoO= NFnHUYpCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDDR25FOSCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> M2XFXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 MkToSpVv[3Srb36gZZN{[Xl? M13nRVUhfU1? M2LVe|I1KGi{cx?= MUHBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCFRFO2JI1TVkFiZYjwdoV{e2mxbjDheEA2KHWPIHHmeIVzKDJ2IHjyd{BjgSCTSVH6c4whemWjZ3XueEBj[XOnZDDSWE1yWEOUIHHuZYx6e2m| MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5OE[wPUc,OzByN{i2NFk9N2F-
MCF7 MYjGeY5kfGmxbjDhd5NigQ>? MoPQOUB2VQ>? NFPtW2czPCCqcoO= M2XqeGFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIFWySlEhdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= M1izclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 Ml\RSpVv[3Srb36gZZN{[Xl? M4LBN|UhfU1? MViyOEBpenN? MV7BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCPS1m2O{BuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG|ZXSgVnQueVCFUjDhcoFtgXOrcx?= M3X4clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 ; 

PubMed: 26163823     


LNCaP-Raf:ER cells were treated with increasing doses of 4-hydroxytamoxifen for 2 days. The bottom panel indicates densitometry of MEK1 and MEK2 signals. Data (mean ± standard error) are from two independent experiments. Pearson’s r = 0.823 for MEK1 and −0.673 for MEK2. 

26163823
Growth inhibition assay
Cell viability; 

PubMed: 26014809     


Dose-dependent effect of 4-hydroxytamoxifen on survival of T47D, MCF-7 and BT-474 cell lines after 96 h of treatment. Control samples were treated with appropriate concentrations of DMSO. Viability was assayed by MTT method.

26014809

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

- 合并
  • Cell lines: 成年大鼠和小鼠心肌细胞
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 礛
  • Incubation Time: 15-45 min
  • Method:

    细胞置于含有4OHT的台式液中,孵育温度为36 ± 1°C,以0.2Hz的频率予以刺激,测量其肌节长度。


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: SD大鼠(Sprague-Dawley rats)
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 387.51
化学式

C26H29NO2

CAS号 68392-35-8
储存条件 粉状
溶于溶剂
别名 Afimoxifene

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Estrogen/progestogen Receptor Signaling Pathway Map

相关Estrogen/progestogen Receptor产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID