4-Hydroxytamoxifen (Afimoxifene)

For research use only. Not for use in humans.

目录号:S7827 别名: Afimoxifene 中文名称:4-羟基三苯氧胺

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1057.45 现货
RMB 958.6 现货
RMB 4070.46 现货
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客户使用Selleck生产的4-Hydroxytamoxifen (Afimoxifene)发表文献11篇:

客户使用该产品的1个实验数据:

  • CDK4/6 inhibitor resistance promotes diminished ER expression and activity. (a and b) Proliferation of MCF-7 and MR cells in the presence of different concentrations of ICI (a) or 4-hydroxytamoxifen (4-OHT) (b) was measured by the alamarBlue assay and plotted as % inhibition of proliferation against log concentration of inhibitor. Each data point represents the average value±s.d. of six replicates obtained in three independent experiments.

    Oncogene, 2016, 36(16):2255-2264. 4-Hydroxytamoxifen (Afimoxifene) purchased from Selleck.

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

生物活性

产品描述 4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。
体外研究

4-OHT是有效的ER激活剂,相比于tamoxifen,它对雌激素受体有更高的亲和力。4-OHT具有较强的剂量和时间依赖式效应,能改变分离出来的大鼠心肌细胞的收缩功能[1]。4-HT可激活intein-Cas9突变体的靶向修饰效率[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells M3XOSHBzd2yrZnXyZZRqd25iYYPzZZk> NH7wSoxKdmirYnn0bY9vKG:oIHXzeJJw\2WwLYP0bY12dGG2ZXSgUWNHNTdiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwNTDuUS=> NV3vVXM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUW0PFgyPyd-OUW0PFgyPzxxYU6=
MCF7 MYDGeY5kfGmxbjDhd5NigQ>? NIfyPIZG\m[nY4TpeoUh\G:|ZTDmc5IhYzOKXT2g[ZN1emGmaX;sJIFo[Wmwc4SgdJJwdGmoZYLheIlwdiCxZjDNR2YuPyClZXzsd{whTUN3MDC9JFAvODByMEOg{txONg>? NEHqVWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[5OlgyLz5{N{[5OlgyRC:jPh?=
MCF7 MUnGeY5kfGmxbjDhd5NigQ>? M3nnUVQhcHK| M2HHXmlv\HWldHnvckBw\iCHUnHsdIhiKGSnZ4Lh[IF1cW:wIHnuJIh2dWGwIF3DSlch[2WubIOgbY4heGinbn;sJJJm\CCocnXlJHJRVUlibXXkbZVuKGOxboThbY5qdmdiNTWgZ4hiemOxYXyg[IV5fHKjbj30doVifGWmIF\CV{BqdmO3YnH0[YQh\m:{IESgbJJ{KGK7IGPQNUBidmRiYX70bU1GWiC{YXLibZQhdW:wb3PvcI5idCCjboTpZo9lgSCkYYPl[EBqdi2lZXzsJHdme3Sncn6gZZN{[XluIFHjeIl3cXS7IE2gNE4xODBzIN88UU4> NUTmVmFmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPFY3OjZpPkOwNFg3PjJ4PD;hQi=>
MCF7 NFOxVJZHfW6ldHnvckBie3OjeR?= NH\GSWNG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NEA:KDBwMECwNVIh|ryPLh?= Mm\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
MCF7 NIT6eFhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFTJe|NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOsJGlEPTBiPTCwMlAxODVizszNMi=> M2jpW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEC1Nlg3Lz5{MkSwOVI5PjxxYU6=
MCF7 NHu1SVNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1fJVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczygTWM2OCB;IECuNFAxPTN5IN88UU4> M{TUd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3NFEzLz5{NkSwO|AyOjxxYU6=
MCF NIfONYlHfW6ldHnvckBie3OjeR?= MXTBcpRi\2:waYP0JIFkfGm4aYT5JIF1KHC{b3fld5Rmem:wZTDy[YNmeHSxcjDpckBpfW2jbjDNR2Yh[2WubIOgZZN{\XO|ZXSgZZMh\XO2cnHkbY9tNWmwZIXj[YQhemWlZYD0c5IhemW|cH;ud4UtKEmFNUCgQUAxNjByMEe5OFMh|ryPLh?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{CxNkc,OjZ2MEewNVI9N2F-
Ishikawa endometrial cells M3jnWmZ2dmO2aX;uJIF{e2G7 MYjB[49vcXO2IHHjeIl3cXS7IHHzJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGmwZIXjeIlwdiCrbjDJd4hqc2G5YTDlcoRwdWW2cnnhcEBk\WyuczDjc41x[XKnZDD0c{BGOixiRVO1NEA:KDBwMECwPEDPxE1w M1r2T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3M{iwNlA5Lz5zNUO4NFIxQDxxYU6=
MCF7 M3jSOGZ2dmO2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQheHKxbHnm[ZJifGmxbjDpckBpfW2jbjDNR2YuPyCkcnXhd5Qh[2GwY3XyJINmdGy|LDDJR|UxKD1iMD6wNFEyPyEQvF2u MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86OTV2OU[zK|46OTV2OU[zQE9iRg>?
MCF7 NGG4NnlHfW6ldHnvckBie3OjeR?= M3PWN|I1KGi{cx?= NWHVO2ZISW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoFteGijIHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDld5Rzd2enbj3pcoR2[2WmIITyZY5{[3KrcITpc44heHKnaX7jeYJifGWmIH;2[ZJvcWeqdDDmc4xtd3enZDDifUBme3S{b3flckBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomg[JVidCCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlAxOyEQvF2u NEfte5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK5OlM6QCd-MkiyPVY{QTh:L3G+
Rosetta 2 DE3 M1XzS2Z2dmO2aX;uJIF{e2G7 NV22XVJGOSCqch?= MVLEbZNxdGGlZX3lcpQhd2ZiW{PIYU1me3S{YXTpc4wh\nKxbTDy[YNwdWKrbnHueEBpfW2jbjDOMZRmem2rbnHsJGhqey22YXfn[YQhTVKjbIDoZUBNSkRiaHHyZo9zcW6pIFOzPFFUN0N2MUfTM2M2OzCVIH31eIFvfCCneIDy[ZN{\WRiaX6gVo9{\XS2YTCyJGRGOyClb33w[ZRmdnRiY3XscJMh[W[2ZYKgNUBpeiCkeTDTVGEh[mmwZHnu[{Bie3OjeTygTWM2OCB;IECuNFA1KM7:TT6= MnzxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
insect cells NWPTfVE1TnWwY4Tpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKG[udX;ycY9v\SCHU{Kg[5Jm\W5iYnnu[Ilv\yC2bzDy[YNwdWKrbnHueEBnfWyuIHzlcod1cCCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OCB;IECuNFA3OjlizszNMi=> M4i3SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{O1NlE1Lz5{OEezOVIyPDxxYU6=
MCF-7-2a M2PUSWZ2dmO2aX;uJIF{e2G7 M{fXNGlvcGmkaYTpc44hd2ZiZYP0doFlcW:uIHnu[JVk\WRiZYP0do9o\W5icnXj[ZB1d3JidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iaX6gUWNHNTdvMnGgZ4VtdHNuIFnDOVAhRSByLkCwO{DPxE1w M{XLd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkeyNlQ6Lz5zMk[3NlI1QTxxYU6=
MCF7 MoK0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{XwR|I1KGi{cx?= MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDBwMEC4OUDPxE1w Mlj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{N{KyOVYoRjF6MkeyNlU3RC:jPh?=
MCF7 NIPjSHNHfW6ldHnvckBie3OjeR?= MYXJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCPQ1[tO{BjemWjc4SgeJVud3JiY3XscJMhfXOrbnegUWNHNTdiYYPzZZktKEmFNUCgQUAxNjByOEWg{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh{NUmzOUc,OTJ6MkW5N|U9N2F-
Ishikawa cells MVjGeY5kfGmxbjDhd5NigQ>? NYXIe21QPzJiaILz MXrBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGW|dILv[4VvKHKnY3XweI9zKGGucHjhM4JmfGFiaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGG|c3H5MEBKSzVyIE2gNE4xOSEQvF2u NV33NVdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlY6OzFpPkK4OFI3QTNzPD;hQi=>
insect cells NVvESVZVTnWwY4Tpc44h[XO|YYm= NEXn[mRFcXOybHHj[Y1mdnRib3[g[ox2d3Knc3PlbY4hdGGkZXzl[EBme3S{YXTpc4wh\nKxbTDoeY1idiC{ZXPvcYJqdmGwdDDFVoJmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR|UxKD1iMD6wNkDPxE1w Mn6xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6M{WxO|YoRjF6OEO1NVc3RC:jPh?=
MCF7 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NFz6dFQ2KGSjeYO= NHzaOlREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFUh\GG7czygTWM2OCB;IECuNFI6OSEQvF2u M1fqV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OE[0PVI5Lz5{M{i2OFkzQDxxYU6=
GT1-7 NYDDVIYxTnWwY4Tpc44h[XO|YYm= M2LJPVIxKHSxIEK0JIhzew>? NV7lUpZ{SW62YXfvcol{fCCjY4Tpeol1gSCjdDDld5Rzd2enbjDy[YNmeHSxcjDpckBud3W|ZTDHWFEuPyClZXzsd{Bp[XKkb4Lpcoch[mW2YT3nZYxi[3Sxc3nkZZNmKHKncH;yeIVzKGenbnWgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIEG3ZoV1[S2nc4TyZYRqd2xiaX7keYNm\CC{ZYPwc45{\SCvZXHzeZJm\CCjZoTldkAzOCC2bzCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwJF0hOC5yM{OyJO69VS5? M{nse|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NECwNlM6Lz5{OESwNFI{QTxxYU6=
insect cells MVTGeY5kfGmxbjDhd5NigQ>? MWfEbZNxdGGlZX3lcpQhd2ZiZnz1c5Jme2OnaX6gcIFj\WynZDDld5Rz[WSrb3yg[pJwdSCqdX3hckBz\WOxbXLpcoFvfCCHUnHsdIhiKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNiYomg[ox2d3Knc3PlcoNmKHCxbHHybZpifGmxbjDhd5NigSxiSVO1NEA:KDBwMESg{txONg>? NV21VWo1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4N|UyPzZpPkG4PFM2OTd4PD;hQi=>
HEK293 NFe3NIhHfW6ldHnvckBie3OjeR?= M2Pi[|MxKG2rboO= MYfJcohq[mm2aX;uJI9nKEeIUD30ZYdo\WRiaIXtZY4hWEyGMjDlfJBz\XO|ZXSgbY4hcHWvYX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJBpd3OyaHH0bYR6dGK3dHHuc4wuY2R7XTDwdo9lfWO2aX;uJIFnfGW{IEOwJI1qdnNiYomgcYF{eyC|cHXjeJJwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNE4xPDRizszNMi=> MnfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzM{[5O|UoRjF7MUO2PVc2RC:jPh?=
HEK293 M2rXbmZ2dmO2aX;uJIF{e2G7 M3SwelEhcHJ? NXPufJNySW62YXfvcol{fCCjY4Tpeol1gSCjdDDy[YNwdWKrbnHueEBpfW2jbjDFVoFteGijIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCnc4TyZYRqd2xvaX7keYNm\CC\RmCt[pV{\WRiU2LDNUBkd2GldHn2ZZRweiC{ZXPyeYl1dWWwdDDt[YF{fXKnZDDh[pRmeiBzIHjyJIlvKHC{ZYPlcoNmKG:oIFPv[YxmdnSncnH6bY5mKEhiYomgRnJGXCCjc4PhfUwhUUN3MDC9JFAvODdizszNMi=> NWfycXlNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>
MCF7 M4jNTGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWq3NkBpenN? M3H1V2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[ZN1em:pZX6gdoVk\XC2b4Kg[IVx\W6mZX70JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVA4KM7:TT6= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh|NUG3Okc,OTh6M{WxO|Y9N2F-
MCF7 M4rLdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUO3NkBpenN? M{fqdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nlidIL5dIFvKGKudXWgZZN{[XluIFfJOVAhRSByLkGwO{DPxE1w MlXCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5M{W4NlkoRjJ|N{O1PFI6RC:jPh?=
MCF7 NHfMNnlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MoPtO|IhcHK| NEXONpVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGVTNWSncHXu[IVvfCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjFzIN88UU4> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{NkmzNUc,Ojh2Mk[5N|E9N2F-
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Ishikawa endometrial cells NISw[nBHfW6ldHnvckBie3OjeR?= M1nZeWFvfGGpb37pd5Qh[WO2aY\peJkh[XNiaX7obYJqfGmxbjDv[kAyKG6PIEG3MYJmfGFvZYP0doFlcW:uIIP0bY12dGG2ZXSgZYxs[WyrbnWgdIhwe3CqYYThd4UhcW6mdXP0bY9vKGmwIFnzbIls[XejIHXu[I9u\XS{aXHsJINmdGy|LDDJR|UxKD1iMD61NUDPxE1w MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTN6MEKwPEc,OTV|OECyNFg9N2F-
CV1 NUPvNWhkTnWwY4Tpc44h[XO|YYm= MVO0OUBpenN? MXLJcpZmenOnIHHnc45qe3RiYXP0bZZqfHliYYSgS2FNPC2GTlGgZolv\GmwZzDkc41icW5vZoXz[YQhdW:3c3WgSXJT\2GvbXGgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBEXjFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gdoVk\XC2b4KgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHHmeIVzKDR3IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlYh|ryPLh?= NXfLW3ZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixPFk{QTNpPkK4NVg6Ozl|PD;hQi=>
CV1 NFLORopHfW6ldHnvckBie3OjeR?= NGDrTJM1PSCqcoO= NIPTdJdKdn[ncoPlJIFod26rc4SgZYN1cX[rdImgZZQhT0GOND3EUmEh[mmwZHnu[{Bld22jaX6t[pV{\WRiaIXtZY4hTVKUYnX0ZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KEOYMTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBz\WOncITvdkB1emGwc3PybZB1cW:wYXygZYN1cX[rdImgZYZ1\XJiNEWgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3MDC9JFAvPjVizszNMi=> M3nmZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUi5N|k{Lz5{OEG4PVM6OzxxYU6=
HEK293 MlrYSpVv[3Srb36gZZN{[Xl? M4jtUmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6g[ZN1em:pZX6gdoVt[XSnZDDy[YNmeHSxcjDnZY1u[SCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3MDC9JFEvOzVizszNMi=> NX7acY5FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU3QDhpPkK1N|A2Pjh6PD;hQi=>
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MCF7 MmfFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIDGXmo1QCCqcoO= M{DmOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDlfJBz\XO|aX7nJIV{fHKxZ3XuJJJm[2WydH;yJIlv[3WkYYTl[EB4cXSqIECuNFYhdk1ib3[g[ZN1emGmaX;sJIFv\CByLkC3JI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSCrbjDwdoV{\W6lZTDv[kBn\XSjbDDic5ZqdmVic3XyeY0h[W6mIF71V4VzfW1uIFfJOVAhRSBzLkmwOVQ3KM7:TT6= M{nNUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUGzNlc2Lz5{MUWxN|I4PTxxYU6=
HeLa NUiydoxmTnWwY4Tpc44h[XO|YYm= MnvqOE42KGi{cx?= M{HIemlvcGmkaYTpc44hd2ZiRXLvcIF3cXK3czDncJlkd3C{b4TlbY4wdWG2cnn4JJBzd3SnaX6gWnA1OCCnboTyfUBqdiCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQvPSCqcoOgZoV1[S2uYXP0ZY1ie2VicnXwc5J1\XJiYYPzZZktKEmFNUCgQUAyNjl4IN88UU4> NEC1VGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[yOFM5Pyd-Mkm2NlQ{QDd:L3G+
MDA-MB-231 NG\vc3FEgXSxdH;4bYNqfHliYYPzZZk> NGXFTnQ1KGSjeYO= NV7oTot3S3m2b4TvfIlkcXS7IHHnZYlve3RiRWKgcoVo[XSrdnWgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyC2cnXheIVlKGW4ZYL5JFIh\GG7czDmc5IhPCCmYYnzJI1m[XO3cnXkJIFnfGW{IEeg[IF6eyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDJwNTFOwG0v MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5OE[wPUc,OzByN{i2NFk9N2F-
MCF7 M4nzWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1\nfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHtu\XSqeXytN2hefGi7bXnkbY5mKGmwdH:gZ4VtdHWuYYKgSG5CKGmwIIPldpVuKG[{ZXWgcYVlcXWvIHnuJIlvKGGkc3XuZ4Uhd2ZiNj6yJJVoN22OIGLOZZNmKDFuIFnDOVAhRSB{Lkeg{txONg>? MmLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4MUG0O|goRjJ{NkGxOFc5RC:jPh?=
MCF7 NIruZ4xCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1jHeFczKGi{cx?= NWXpVXFZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlc6KM7:TT6= NIHINVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki5OlcxPid-Mk[4PVY4ODZ:L3G+
MCF12A NVTRbpRvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXv4W2NIPDhiaILz NFvmW4lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuJJJm[2WydH;yMYRm\mmlaXXueEBpfW2jbjDNR2YyOkFiY3XscJMhcW6ldXLheIVlKHerdHigNVAxKG6PIH;mJIV{fHKjZHnvcEBidmRiMD6wO{BvVSCxZjD0[ZN1d3O2ZYLvcoUh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XliaX6gdJJme2WwY3Wgc4Yh\mW2YXygZo93cW6nIIPldpVuKGGwZDDOeXNmenWvLDDHTVUxKD1iMz6yN|U6PCEQvF2u M12yU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUGzNlc2Lz5{MUWxN|I4PTxxYU6=
MCF7 MmLwR5l1d3SxeHnjbZR6KGG|c3H5 MnjtOEBl[Xm| MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBGWiCyb4PpeIl3\SCqdX3hckBOS0Z5IHPlcIx{KHS{ZXH0[YQh\X[ncomgNkBl[Xm|IH\vdkA1KGSjeYOgcYVie3W{ZXSgZYZ1\XJiNzDkZZl{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOy5|IN88UU4> Mn36QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF12A NHL0e3BCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWXWNY9vPDhiaILz NX\nd495SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBme3S{b3flckBz\WOncITvdk1l\W[rY3nlcpQhcHWvYX6gUWNHOTKDIHPlcIx{KGmwY4XiZZRm\CC5aYToJFAvODB|IH7NJI9nKGW|dILh[IlwdCCjbnSgNE4xOSCwTTDv[kB1\XO2b4P0[ZJwdmViYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmgbY4heHKnc3XuZ4Uhd2ZiNTWg[oV1[WxiYn;2bY5mKHOncoXtMEBIUTVyIE2gN{4{OTF|MTFOwG0v MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K3OUc,OjF3MUOyO|U9N2F-
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MDA-MB-231 Ml;oR5l1d3SxeHnjbZR6KGG|c3H5 NELrVWw1KGSjeYO= NXjyUJJ6S3m2b4TvfIlkcXS7IHHnZYlve3RiRWKgcoVo[XSrdnWgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyC2cnXheIVlKGW4ZYL5JFIh\GG7czDmc5IhPCCmYYnzJI1m[XO3cnXkJJBwe3RibHHzeEBld3OnIHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDJR|UxKD1iMz61JO69VS5? MoK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
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MCF7 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MUG0JIRigXN? M13VSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEWUIIDvd4l1cX[nIHj1cYFvKE2FRkegZ4VtdHNidILlZZRm\CCndnXyfUAzKGSjeYOg[o9zKDRiZHH5d{Bu\WG|dYLl[EBxd3O2IHzhd5Qh\G:|ZTDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX7j[UBie3OjeTygTWM2OCB;IEOuPUDPxE1w M4f0UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 NVLqSXJWTnWwY4Tpc44h[XO|YYm= MljrTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JJBzd2yrZnXyZZRqd25ib3[gUWNHNTdiY3XscJMhcW5icILld4Vv[2Vib3[gNVBmNTZiTTDjc45k\W62cnH0bY9vKG:oIGuzTH0uKGW|dILh[IlwdCBqRUKpMEBKSzNyIE2gOEDPxE1w MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ7NkixK|4zPzZ7NkixQE9iRg>?
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NCI-ADR-RES M17JXmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUm0PEBpenN? NHXLe5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuJJJm[2WydH;yMYRm\mmlaXXueEBpfW2jbjDOR2kuSUSULWLFV{Bk\WyuczDpcoN2[mG2ZXSge4l1cCByLkCwN{BvVSCxZjDld5Rz[WSrb3ygZY5lKDBwMEGgcm0hd2ZidHXzeI9{fGW{b37lJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFUmKG[ndHHsJIJwfmmwZTDz[ZJ2dSxiR1m1NEA:KDRwNE[2PFQh|ryPLh?= MlXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyO|UoRjJzNUGzNlc2RC:jPh?=
BT-20 NEXOe|BHfW6ldHnvckBie3OjeR?= MV6xNEDPxE1? M1LYdWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBxem:uaX\ldoF1cW:wIH;mJGJVNTJyIHPlcIx{KGmwIIDy[ZNmdmOnIH;mJHRRTSCjdDCxNIUuPSCPIHPvcoNmdnS{YYTpc44tKEmFM{CgQUA1NjhizszNMi=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ7NkixK|4zPzZ7NkixQE9iRg>?
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MCF7 NYrBXG9DTnWwY4Tpc44h[XO|YYm= M{DD[|UhfU1? MWeyOEBpenN? M1;MU2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIFPDUmQyKG2UTlGg[ZhxemW|c3nvckBifCB3IIXNJIFnfGW{IEK0JIhzeyCkeTDRTWF7d2xicnXh[4VvfCCkYYPl[EBTXC2zUFPSJIFv[Wy7c3nz M2DXd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
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MCF7 MmX4SpVv[3Srb36gZZN{[Xl? M3frNVUhfU1? NWnE[GVjOjRiaILz MY\BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCHMl[xJI1TVkFiZYjwdoV{e2mxbjDheEA2KHWPIHHmeIVzKDJ2IHjyd{BjgSCTSVH6c4whemWjZ3XueEBj[XOnZDDSWE1yWEOUIHHuZYx6e2m| MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5OE[wPUc,OzByN{i2NFk9N2F-
MCF7 NXrVU2EzTnWwY4Tpc44h[XO|YYm= NWDhZYF6PSC3TR?= NWLvO5ExOjRiaILz NEjXdFRCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDNT2k3PyCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> M3[1PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 ; 

PubMed: 26163823     


LNCaP-Raf:ER cells were treated with increasing doses of 4-hydroxytamoxifen for 2 days. The bottom panel indicates densitometry of MEK1 and MEK2 signals. Data (mean ± standard error) are from two independent experiments. Pearson’s r = 0.823 for MEK1 and −0.673 for MEK2. 

26163823
Growth inhibition assay
Cell viability; 

PubMed: 26014809     


Dose-dependent effect of 4-hydroxytamoxifen on survival of T47D, MCF-7 and BT-474 cell lines after 96 h of treatment. Control samples were treated with appropriate concentrations of DMSO. Viability was assayed by MTT method.

26014809

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

- 合并
  • Cell lines: 成年大鼠和小鼠心肌细胞
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 礛
  • Incubation Time: 15-45 min
  • Method:

    细胞置于含有4OHT的台式液中,孵育温度为36 ± 1°C,以0.2Hz的频率予以刺激,测量其肌节长度。


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: SD大鼠(Sprague-Dawley rats)
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 387.51
化学式

C26H29NO2

CAS号 68392-35-8
储存条件 粉状
溶于溶剂
别名 Afimoxifene

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Estrogen/progestogen Receptor Signaling Pathway Map

相关Estrogen/progestogen Receptor产品

Tags: 购买4-Hydroxytamoxifen (Afimoxifene) | 4-Hydroxytamoxifen (Afimoxifene)供应商 | 采购4-Hydroxytamoxifen (Afimoxifene) | 4-Hydroxytamoxifen (Afimoxifene)价格 | 4-Hydroxytamoxifen (Afimoxifene)生产 | 订购4-Hydroxytamoxifen (Afimoxifene) | 4-Hydroxytamoxifen (Afimoxifene)代理商
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID