4-Hydroxytamoxifen (Afimoxifene)

目录号:S7827 别名: Afimoxifene 中文名称:4-羟基三苯氧胺

仅限科研使用

4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS: 68392-35-8

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1057.45 现货
RMB 958.6 现货
RMB 4070.46 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的4-Hydroxytamoxifen (Afimoxifene)发表文献13篇:

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

相关Estrogen/progestogen Receptor产品

生物活性

产品描述 4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。
体外研究

4-OHT是有效的ER激活剂,相比于tamoxifen,它对雌激素受体有更高的亲和力。4-OHT具有较强的剂量和时间依赖式效应,能改变分离出来的大鼠心肌细胞的收缩功能[1]。4-HT可激活intein-Cas9突变体的靶向修饰效率[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NYLsSml1WHKxbHnm[ZJifGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGW|dILv[4VvNXO2aX31cIF1\WRiTVPGMVch[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvPSCwTR?= M3\VN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl3NEi4NVcoRjl3NEi4NVc9N2F-
MCF7 NGm2XlRHfW6ldHnvckBie3OjeR?= MUjF[oZm[3SrdnWg[I9{\SCob4KgX|NJZS1iZYP0doFlcW:uIHHnZYlve3RicILvcIln\XKjdHnvckBw\iCPQ1[tO{Bk\WyuczygSWM2OCB;IECuNFAxODNizszNMi=> M4jFdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nkm2PFEoRjJ5Nkm2PFE9N2F-
MCF7 NVnXZ|ZvTnWwY4Tpc44h[XO|YYm= NEnCO4E1KGi{cx?= M{m1U2lv\HWldHnvckBw\iCHUnHsdIhiKGSnZ4Lh[IF1cW:wIHnuJIh2dWGwIF3DSlch[2WubIOgbY4heGinbn;sJJJm\CCocnXlJHJRVUlibXXkbZVuKGOxboThbY5qdmdiNTWgZ4hiemOxYXyg[IV5fHKjbj30doVifGWmIF\CV{BqdmO3YnH0[YQh\m:{IESgbJJ{KGK7IGPQNUBidmRiYX70bU1GWiC{YXLibZQhdW:wb3PvcI5idCCjboTpZo9lgSCkYYPl[EBqdi2lZXzsJHdme3Sncn6gZZN{[XluIFHjeIl3cXS7IE2gNE4xODBzIN88UU4> NF;sZ|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC4OlYzPid-M{CwPFY3OjZ:L3G+
MCF7 NXPnSm5FTnWwY4Tpc44h[XO|YYm= M1HGc2Vn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiTVPGMVch[nKnYYP0JJR2dW:{IHPlcIx{KHW|aX7nJG1ETi15IHHzd4F6NCCHQ{WwJF0hOC5yMECxNkDPxE1w Mmj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
MCF7 NELh[Y9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mmm3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wNFA2KM7:TT6= MmWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2MEWyPFYoRjJ{NEC1Nlg3RC:jPh?=
MCF7 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4PVeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczygTWM2OCB;IECuNFAxPTN5IN88UU4> M1HZelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3NFEzLz5{NkSwO|AyOjxxYU6=
MCF MXPGeY5kfGmxbjDhd5NigQ>? NF3XfGRCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IIDyc4dme3Sncn;u[UBz\WOncITvdkBqdiCqdX3hckBOS0ZiY3XscJMh[XO|ZYPz[YQh[XNiZYP0doFlcW:uLXnu[JVk\WRicnXj[ZB1d3JicnXzdI9ve2VuIFnDOVAhRSByLkCwNFc6PDNizszNMi=> M{K1Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3NFEzLz5{NkSwO|AyOjxxYU6=
Ishikawa endometrial cells M3zHTGZ2dmO2aX;uJIF{e2G7 NVjzbGFxSWexbnnzeEBi[3Srdnn0fUBieyCjbHvhcIlv\SCyaH;zdIhifGG|ZTDpcoR2[3Srb36gbY4hUXOqaXvhe4Eh\W6mb33leJJq[WxiY3XscJMh[2:vcHHy[YQhfG9iRUKsJGVEPTBiPTCwMlAxODhizszNMi=> MlXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV|OECyNFgoRjF3M{iwNlA5RC:jPh?=
MCF7 NWnndHZXTnWwY4Tpc44h[XO|YYm= MoHJTY5pcWKrdHnvckBw\iCnc4Tyc4dmdi2rbnT1Z4VlKHC{b3zp[oVz[XSrb36gbY4hcHWvYX6gUWNHNTdiYoLlZZN1KGOjbnPldkBk\WyuczygTWM2OCB;IECuNFAyOTdizszNMi=> M3uwS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlzNUS5OlMoRjlzNUS5OlM9N2F-
MCF7 NXHEd4d1TnWwY4Tpc44h[XO|YYm= MXmyOEBpenN? MVvBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQhfHKjboPjdolxfGmxbjDwdoVqdmO3YnH0[YQhd3[ncn7p[4h1KG[xbHzve4VlKGK7IHXzeJJw\2WwIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCmdXHsJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NEA:KDBwMECzJO69VS5? MkDtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
Rosetta 2 DE3 M{LWWGZ2dmO2aX;uJIF{e2G7 MnPENUBpeg>? MkT2SIl{eGyjY3Xt[Y51KG:oIGuzTH0u\XO2cnHkbY9tKG[{b32gdoVkd22kaX7hcpQhcHWvYX6gUk11\XKvaX7hcEBJcXNvdHHn[4VlKEWUYXzwbIEhVEKGIHjhdoJwemmwZzDDN|gyWy:FNEG3V{9EPTNyUzDteZRidnRiZYjwdoV{e2WmIHnuJHJwe2W2dHGgNkBFTTNiY3;tdIV1\W62IHPlcIx{KGGodHXyJFEhcHJiYomgV3BCKGKrbnTpcoch[XO|YYmsJGlEPTBiPTCwMlAxPCEQvF2u NXq2N3JERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPVY{QThpPkK4Nlk3Ozl6PD;hQi=>
insect cells MkTTSpVv[3Srb36gZZN{[Xl? Moj6TY5pcWKrdHnvckBw\iCobIXvdo1wdmViRWOyJIdz\WWwIHLpcoRqdmdidH:gdoVkd22kaX7hcpQh\nWubDDs[Y5ofGhiaIXtZY4hTVKjbIDoZUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIJ6KG[udX;y[ZNk\W6lZTDwc4xiemm8YYTpc44h[XO|YYmsJGlEPTBiPTCwMlAxPjJ7IN88UU4> NFHxOm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEezOVIyPCd-Mki3N|UzOTR:L3G+
MCF-7-2a M37CeWZ2dmO2aX;uJIF{e2G7 MnnlTY5pcWKrdHnvckBw\iCnc4TyZYRqd2xiaX7keYNm\CCnc4Tyc4dmdiC{ZXPldJRweiC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCrbjDNR2YuPy1{YTDj[YxteyxiSVO1NEA:KDBwMEC3JO69VS5? NUnUcYl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2O|IzPDlpPkGyOlczOjR7PD;hQi=>
MCF7 NUfxWWdZSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYWyOEBpenN? MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDBwMEC4OUDPxE1w M2TkflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkeyNlU3Lz5zOEK3NlI2PjxxYU6=
MCF7 Mn3PSpVv[3Srb36gZZN{[Xl? NGKzUG9KdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFnDOVAhRSByLkCwPFUh|ryPLh?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh{NUmzOUc,OTJ6MkW5N|U9N2F-
Ishikawa cells NEn2ZWRHfW6ldHnvckBie3OjeR?= MnXJO|IhcHK| NFL1e45CdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHHsdIhiN2KndHGgbY4hcHWvYX6gTZNpcWujd3GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGua3HsbY5mKHCqb4PwbIF1[XOnIHHzd4F6NCCLQ{WwJF0hOC5yMTFOwG0v NVKyblRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlY6OzFpPkK4OFI3QTNzPD;hQi=>
insect cells M{T2WmZ2dmO2aX;uJIF{e2G7 NGPQfpNFcXOybHHj[Y1mdnRib3[g[ox2d3Knc3PlbY4hdGGkZXzl[EBme3S{YXTpc4wh\nKxbTDoeY1idiC{ZXPvcYJqdmGwdDDFVoJmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR|UxKD1iMD6wNkDPxE1w NVfid5VqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4N|UyPzZpPkG4PFM2OTd4PD;hQi=>
MCF7 MYTDfZRwfG:6aXPpeJkh[XO|YYm= M4DiXlUh\GG7cx?= NXfKNlZrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA2KGSjeYOsJGlEPTBiPTCwMlAzQTFizszNMi=> M1PlfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OE[0PVI5Lz5{M{i2OFkzQDxxYU6=
GT1-7 M4HCO2Z2dmO2aX;uJIF{e2G7 MUOyNEB1dyB{NDDodpM> MnjtRY51[WexbnnzeEBi[3Srdnn0fUBifCCnc4Tyc4dmdiC{ZXPldJRweiCrbjDtc5V{\SCJVEGtO{Bk\WyuczDoZZJjd3KrbnegZoV1[S2pYXzhZ5Rwe2mmYYPlJJJmeG:{dHXyJIdmdmViYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKDF5YnX0ZU1me3S{YXTpc4whcW6mdXPl[EBz\XOyb37z[UBu\WG|dYLl[EBi\nSncjCyNEB1dyB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyIE2gNE4xOzN{IN88UU4> M{HWOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NECwNlM6Lz5{OESwNFI{QTxxYU6=
insect cells Ml7JSpVv[3Srb36gZZN{[Xl? M33LTWRqe3CuYXPlcYVvfCCxZjDmcJVwemW|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZYxxcGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR|UxKD1iMD6wOEDPxE1w NHf0UWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEizOVE4Pid-MUi4N|UyPzZ:L3G+
HEK293 NX7lNIRVTnWwY4Tpc44h[XO|YYm= MoDuN|AhdWmwcx?= M4fyXmlvcGmkaYTpc44hd2ZiR1\QMZRi\2enZDDoeY1idiCSTFSyJIV5eHKnc4Pl[EBqdiCqdX3hckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heGixc4DoZZRq\HmuYoX0ZY5wdC2dZEndJJBzd2S3Y4Tpc44h[W[2ZYKgN|AhdWmwczDifUBu[XO|IIPw[YN1em:vZYTybYMh[W6jbInzbZMtKEmFNUCgQUAxNjB2NDFOwG0v MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF|Nkm3OUc,OTlzM{[5O|U9N2F-
HEK293 MmXCSpVv[3Srb36gZZN{[Xl? MWGxJIhz MWPBcpRi\2:waYP0JIFkfGm4aYT5JIF1KHKnY3;tZolv[W62IHj1cYFvKEWUYXzwbIEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKjZHnvcE1qdmS3Y3XkJHlHWC2odYPl[EBUWkNzIHPvZYN1cX[jdH;yJJJm[3K3aYTt[Y51KG2nYYP1doVlKGGodHXyJFEhcHJiaX6gdJJme2WwY3Wgc4YhS2:nbHXueIVz[XqrbnWgTEBjgSCEUlXUJIF{e2G7LDDJR|UxKD1iMD6wO{DPxE1w NIPPUIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 M2faO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVK3NkBpenN? NFvF[pJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuJJJm[2WydH;yJIRmeGWwZHXueEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlExPyEQvF2u MlT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6M{WxO|YoRjF6OEO1NVc3RC:jPh?=
MCF7 NWHIOIJxSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWK0UFNCPzJiaILz NWnSeIIxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTD0dplx[W5iYnz1[UBie3OjeTygS2k2OCB;IECuNVA4KM7:TT6= MlHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5M{W4NlkoRjJ|N{O1PFI6RC:jPh?=
MCF7 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4rGSVczKGi{cx?= NVXCN25DSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBGWi2mZYDlcoRmdnRiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zMTFOwG0v NVvPZllKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlY6OzFpPkK4OFI3QTNzPD;hQi=>
T47D Mn7pR5l1d3SxeHnjbZR6KGG|c3H5 NHi5em42KGSjeYO= NYDTcZNvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXDR5RDDj[YxteyCjZoTldkA2KGSjeYOsJGlEPTBiPTCwMlIyKM7:TT6= NFToeG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i2OFkzQCd-MkO4OlQ6Ojh:L3G+
Ishikawa endometrial cells MlOxSpVv[3Srb36gZZN{[Xl? M3zWeGFvfGGpb37pd5Qh[WO2aY\peJkh[XNiaX7obYJqfGmxbjDv[kAyKG6PIEG3MYJmfGFvZYP0doFlcW:uIIP0bY12dGG2ZXSgZYxs[WyrbnWgdIhwe3CqYYThd4UhcW6mdXP0bY9vKGmwIFnzbIls[XejIHXu[I9u\XS{aXHsJINmdGy|LDDJR|UxKD1iMD61NUDPxE1w M3j5TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3M{iwNlA5Lz5zNUO4NFIxQDxxYU6=
CV1 NHzv[WpHfW6ldHnvckBie3OjeR?= NWTJVHB5PDViaILz NYXXSpdSUW64ZYLz[UBi\2:waYP0JIFkfGm4aYT5JIF1KEeDTEStSG5CKGKrbnTpcoch\G:vYXnuMYZ2e2WmIH3veZNmKEWUUnfhcY1iKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbjDlfJBz\XO|ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliQ2[xJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHKnY3XweI9zKHS{YX7zZ5JqeHSrb37hcEBi[3Srdnn0fUBi\nSncjC0OUBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwJF0hOC54IN88UU4> NFPPUYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG4PVM6Oyd-MkixPFk{QTN:L3G+
CV1 MkLISpVv[3Srb36gZZN{[Xl? MXK0OUBpenN? M4qzOWlvfmW{c3WgZYdwdmm|dDDhZ5Rqfmm2eTDheEBISUx2LVTORUBjcW6maX7nJIRwdWGrbj3meZNm\CCqdX3hckBGWlKkZYThJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCneIDy[ZN{\WRiaX6gRYZzcWOjbjDndoVmdiCvb37r[ZkhS1ZzIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJJm[2WydH;yJJRz[W6|Y4LpdJRqd26jbDDhZ5Rqfmm2eTDh[pRmeiB2NTDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyIE2gNE43PSEQvF2u NFm2T|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG4PVM6Oyd-MkixPFk{QTN:L3G+
HEK293 MWHGeY5kfGmxbjDhd5NigQ>? M{DtS2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6g[ZN1em:pZX6gdoVt[XSnZDDy[YNmeHSxcjDnZY1u[SCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3MDC9JFEvOzVizszNMi=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNyNU[4PEc,OjV|MEW2PFg9N2F-
MCF7 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoXaOFghcHK| NULuOWU6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNE4xODNibl2gc4Yh\XO2cnHkbY9tKGGwZDCwMlAyKG6PIH;mJJRme3Sxc4Tldo9v\SCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTDpckBxemW|ZX7j[UBw\iB3JTDm[ZRidCCkb4\pcoUhe2W{dX2sJGdKPTBiPTCxMlQyOjV2IN88UU4> NVjBTIlJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzPzVpPkKxOVE{Ojd3PD;hQi=>
MCF7 M3HjTGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXj0bFFLPDhiaILz MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiZYjwdoV{e2mwZzDld5Rzd2enbjDy[YNmeHSxcjDpcoN2[mG2ZXSge4l1cCByLkC2JI5OKG:oIHXzeJJi\GmxbDDhcoQhOC5yNzDuUUBw\iC2ZYP0c5N1\XKxbnWgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZkhcW5icILld4Vv[2Vib3[g[oV1[WxiYn;2bY5mKHOncoXtJIFv\CCQdWPldpVuNCCJSUWwJF0hOS57MEW0OkDPxE1w MkTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyO|UoRjJzNUGzNlc2RC:jPh?=
HeLa MVLGeY5kfGmxbjDhd5NigQ>? M2Hm[VQvPSCqcoO= NWXmXm1xUW6qaXLpeIlwdiCxZjDFZo9t[X[rcoXzJIdtgWOxcILveIVqdi:vYYTybZgheHKxdHXpckBXWDRyIHXueJJ6KGmwIHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPC53IHjyd{Bj\XSjLXzhZ5RidWG|ZTDy[ZBwenSncjDhd5NigSxiSVO1NEA:KDFwOU[g{txONg>? NGH4[og9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[yOFM5Pyd-Mkm2NlQ{QDd:L3G+
MDA-MB-231 M4fZOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXm0JIRigXN? MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBGWiCwZXfheIl3\SCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJJRz\WG2ZXSg[ZZmenliMjDkZZl{KG[xcjC0JIRigXNibXXhd5Vz\WRiYX\0[ZIhPyCmYYnzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcoNmKGG|c3H5MEBKSzVyIE2gNk42KM7:TT6= NI\aNHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 NH33XoFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kd3Kyb4LheIlwdiCxZjDbcYV1cHmuLUPIYZRpgW2rZHnu[UBqdnSxIHPlcIx2dGG{IFTORUBqdiC|ZYL1cUBnemWnIH3l[Il2dSCrbjDpckBi[nOnbnPlJI9nKDZwMjD1[{9uVCCUTnHz[UAyNCCLQ{WwJF0hOi55IN88UU4> NWLUNZJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NVE1PzhpPkKyOlEyPDd6PD;hQi=>
MCF7 MoHIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYK3NkBpenN? M{nvZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj63PUDPxE1w M1PaVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEm2O|A3Lz5{Nki5OlcxPjxxYU6=
MCF12A M1rJbmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHz4T401QCCqcoO= M4fBT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[ZN1em:pZX6gdoVk\XC2b4Kt[IVncWOrZX70JIh2dWGwIF3DSlEzSSClZXzsd{BqdmO3YnH0[YQhf2m2aDCxNFAhdk1ib3[g[ZN1emGmaX;sJIFv\CByLkC3JI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSCrbjDwdoV{\W6lZTDv[kBn\XSjbDDic5ZqdmVic3XyeY0h[W6mIF71V4VzfW1uIFfJOVAhRSB|LkKzOVk1KM7:TT6= M{jWRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUGzNlc2Lz5{MUWxN|I4PTxxYU6=
MCF7 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MlHJOEBl[Xm| NH3UNo1EgXSxdH;4bYNqfHliYXfhbY5{fCCHUjDwc5NqfGm4ZTDoeY1idiCPQ1[3JINmdGy|IITy[YF1\WRiZY\ldpkhOiCmYYnzJIZweiB2IHThfZMhdWWjc4Xy[YQh[W[2ZYKgO{Bl[Xm|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDJR|UxKD1iMz6zJO69VS5? NEfjcos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF12A MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1LSdVQ5KGi{cx?= MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHXzeJJw\2WwIILlZ4VxfG:{LXTl[olkcWWwdDDoeY1idiCPQ1[xNmEh[2WubIOgbY5kfWKjdHXkJJdqfGhiMD6wNFMhdk1ib3[g[ZN1emGmaX;sJIFv\CByLkCxJI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSCrbjDwdoV{\W6lZTDv[kA2LSCoZYThcEBjd3[rbnWgd4VzfW1uIFfJOVAhRSB|LkOxNVMyKM7:TT6= MnS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyO|UoRjJzNUGzNlc2RC:jPh?=
MCF7 M2CxO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NUnjNJF[PDhiaILz NWLIfXhMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNVAxKG6PIH;mJIV{fHKjZHnvcEBidmRiMD6wO{BvVSCxZjD0[ZN1d3O2ZYLvcoUh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XliaX6gdJJme2WwY3Wgc4Yh\mW2YXygZo93cW6nIIPldpVuKGGwZDDOeXNmenWvLDDHTVUxKD1iMz60Olc{PyEQvF2u NWq3RpgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzPzVpPkKxOVE{Ojd3PD;hQi=>
MDA-MB-231 M3TuXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NHv0WG81KGSjeYO= Mnq2R5l1d3SxeHnjbZR6KGGpYXnud5QhTVJibnXnZZRqfmViaIXtZY4hVUSDLV3CMVI{OSClZXzsd{B1emWjdHXkJIV3\XK7IEKg[IF6eyCob4KgOEBl[Xm|IH3lZZN2emWmIIDvd5QhdGG|dDDkc5NmKGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOy53IN88UU4> NFL6V4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF12A MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MV20PEBpenN? MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHXzeJJw\2WwIILlZ4VxfG:{LXTl[olkcWWwdDDoeY1idiCPQ1[xNmEh[2WubIOgbY5kfWKjdHXkJJdqfGhiMD6wOkBvVSCxZjDld5Rz[WSrb3ygZY5lKDBwMEegcm0hd2ZidHXzeI9{fGW{b37lJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJIZmfGGuIHLveolv\SC|ZYL1cUBidmRiToXT[ZJ2dSxiR1m1NEA:KDNwOEmwOFUh|ryPLh?= NXHmZoVKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzPzVpPkKxOVE{Ojd3PD;hQi=>
MCF7 NYXlcmhpS3m2b4TvfIlkcXS7IHHzd4F6 MVO0JIRigXN? NGryN2hEgXSxdH;4bYNqfHliYXfhbY5{fCCHUjDwc5NqfGm4ZTDoeY1idiCPQ1[3JINmdGy|IITy[YF1\WRiZY\ldpkhOiCmYYnzJIZweiB2IHThfZMhdWWjc4Xy[YQheG:|dDDsZZN1KGSxc3WgZpkhS2WubGTpeIVzNUeubzDseY1qdmW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCzMlkh|ryPLh?= NF;4e|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 NV\HV3Q3TnWwY4Tpc44h[XO|YYm= MoXuTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JJBzd2yrZnXyZZRqd25ib3[gUWNHNTdiY3XscJMhcW5icILld4Vv[2Vib3[gNVBmNTZiTTDjc45k\W62cnH0bY9vKG:oIGuzTH0uKGW|dILh[IlwdCBqRUKpMEBKSzNyIE2gOEDPxE1w MonhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4OU[4NUc,Ojd4OU[4NVww[T5?
MCF10A M3Wyd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVryV|ZPPCCmYYnz MnfPR5l1d3SxeHnjbZR6KGGpYXnud5QhTVJibnXnZZRqfmViaIXtZY4hVUOIMUDBJINmdGy|IITy[YF1\WRiZY\ldpkhOiCmYYnzJIZweiB2IHThfZMhdWWjc4Xy[YQheG:|dDDsZZN1KGSxc3WgZpkhS2WubGTpeIVzNUeubzDseY1qdmW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTC0JO69VS5? NUS1R4M4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>
MCF10A M2rYXmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIT3bFk1KGSjeYO= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBGWiCwZXfheIl3\SCqdX3hckBOS0ZzMFGgZ4VtdHNidILlZZRm\CCndnXyfUAzKGSjeYOg[o9zKDRiZHH5d{Bu\WG|dYLl[EBi\nSncjC3JIRigXNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwY3WgZZN{[XluIFnDOVAhRSB2IN88UU4> MoHqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
yeast cells MV;BcpRq\XO2cn;n[Y5q[yCjc4PhfS=> NXLZVGFkSW62aXXzeJJw\2WwaXOgZYN1cX[rdImgZZQh\XO2cn;n[Y4hemWlZYD0c5Ih[WyyaHGg[ZhxemW|c3XkJIlvKHmnYYP0JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiMUetZoV1[S2nc4TyZYRqd2xvaX7keYNm\CCkZYThMYdidGGldH;zbYRie2ViYXP0bZZqfHliYomgeJdwKGi7YoLp[EBie3OjeTygTWM2OCB;IESuOEDPxE1w M3;GR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NESxNFg3Lz5zNkS0NVA5PjxxYU6=
NCI-ADR-RES MorBRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NVrDPI5iPDhiaILz Mo\5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDld5Rzd2enbjDy[YNmeHSxcj3k[YZq[2mnboSgbJVu[W5iTlPJMWFFWi2URWOgZ4VtdHNiaX7jeYJifGWmIIfpeIghOC5yMEOgcm0hd2ZiZYP0doFlcW:uIHHu[EAxNjBzIH7NJI9nKHSnc4Tvd5Rmem:wZTDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUBqdiCycnXz[Y5k\SCxZjC1KUBn\XSjbDDic5ZqdmVic3XyeY0tKEeLNUCgQUA1NjR4Nki0JO69VS5? NFn2[Fc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN|I4PSd-MkG1NVMzPzV:L3G+
BT-20 MoPFSpVv[3Srb36gZZN{[Xl? MmTSNVAh|ryP NFPTXFJKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QheHKxbHnm[ZJifGmxbjDv[kBDXC1{MDDj[YxteyCrbjDwdoV{\W6lZTDv[kBVWEViYYSgNVBmNTViTTDjc45k\W62cnH0bY9vNCCLQ{OwJF0hPC56IN88UU4> NEW3N5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[5OlgyLz5{N{[5OlgyRC:jPh?=
Calu-1 NHfrdHZHfW6ldHnvckBie3OjeR?= MkHXN|AhdWmwcx?= M4nhVmlvcGmkaYTpc44hd2ZiUFzENUBqdiCqdX3hckBE[Wy3LUGgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heGixc4DoZZRq\HmuYoX0ZY5wdC2dZEndJJBzd2S3Y4Tpc44h[W[2ZYKgN|AhdWmwczDifUBu[XO|IIPw[YN1em:vZYTybYMh[W6jbInzbZMtKEmFNUCgQUA1NjhizszNMi=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF|Nkm3OUc,OTlzM{[5O|U9N2F-
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MCF7 NWjDPXR[TnWwY4Tpc44h[XO|YYm= NW\vbHY3PSC3TR?= MmjoNlQhcHK| NIDwZlRCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDNXWMhdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= NWjIZnVJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>
MCF7 M{PNbWZ2dmO2aX;uJIF{e2G7 MXy1JJVO MV[yOEBpenN? MV\BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCWRl[xJI1TVkFiZYjwdoV{e2mxbjDheEA2KHWPIHHmeIVzKDJ2IHjyd{BjgSCTSVH6c4whemWjZ3XueEBj[XOnZDDSWE1yWEOUIHHuZYx6e2m| MmHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 NHX3SZlHfW6ldHnvckBie3OjeR?= NInJUZo2KHWP MWOyOEBpenN? NHrLeIFCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDHVmVDOSCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> MnTFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 M1XGZWZ2dmO2aX;uJIF{e2G7 M2TWVVUhfU1? NWmzSYlSOjRiaILz NF\TZWhCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDNXWJNOiCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> NYDuNmJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>
MCF7 MnvuSpVv[3Srb36gZZN{[Xl? M4L2V|UhfU1? MUWyOEBpenN? MnXNRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiQ1POSFEhdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= M1nnU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 Mom1SpVv[3Srb36gZZN{[Xl? NFn3Nmc2KHWP NVrGW2F3OjRiaILz MkP5RY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiQ1TDOkBuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG|ZXSgVnQueVCFUjDhcoFtgXOrcx?= M4rUS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 MWPGeY5kfGmxbjDhd5NigQ>? MkSxOUB2VQ>? MYSyOEBpenN? NFvMR21CdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDFNmYyKG2UTlGg[ZhxemW|c3nvckBifCB3IIXNJIFnfGW{IEK0JIhzeyCkeTDRTWF7d2xicnXh[4VvfCCkYYPl[EBTXC2zUFPSJIFv[Wy7c3nz Mk[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 NVLVdoE{TnWwY4Tpc44h[XO|YYm= Mm\yOUB2VQ>? M{LKU|I1KGi{cx?= MmCxRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiTVvJOlchdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= M3L5W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
Assay
Methods Test Index PMID
Western blot p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 26163823
Growth inhibition assay Cell viability 26014809

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

  • Cell lines: 成年大鼠和小鼠心肌细胞
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 礛
  • Incubation Time: 15-45 min
  • Method:

    细胞置于含有4OHT的台式液中,孵育温度为36 ± 1°C,以0.2Hz的频率予以刺激,测量其肌节长度。

动物实验:

[2]

  • Animal Models: SD大鼠(Sprague-Dawley rats)
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: 口服

溶解度(25°C)

体外

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 387.51
化学式

C26H29NO2

CAS号 68392-35-8
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05133674 Active not recruiting Drug: Tamoxifen 20 mg Breast Cancer|Breast Carcinoma|Breast Tumors|Cancer of Breast|Malignant Neoplasm of Breast Karolinska University Hospital April 4 2022 Phase 2
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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