4-Hydroxytamoxifen(Afimoxifene)

For research use only. Not for use in humans.

目录号:S7827 别名: Afimoxifene 中文名称:4-羟基三苯氧胺

4-Hydroxytamoxifen(Afimoxifene) Chemical Structure

CAS No. 68392-35-8

4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 794.43 现货
RMB 958.6 现货
RMB 4070.46 现货
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客户使用Selleck生产的4-Hydroxytamoxifen(Afimoxifene)发表文献7篇:

客户使用该产品的1个实验数据:

  • CDK4/6 inhibitor resistance promotes diminished ER expression and activity. (a and b) Proliferation of MCF-7 and MR cells in the presence of different concentrations of ICI (a) or 4-hydroxytamoxifen (4-OHT) (b) was measured by the alamarBlue assay and plotted as % inhibition of proliferation against log concentration of inhibitor. Each data point represents the average value±s.d. of six replicates obtained in three independent experiments.

    Oncogene, 2016, 36(16):2255-2264. 4-Hydroxytamoxifen(Afimoxifene) purchased from Selleck.

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

生物活性

产品描述 4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。
体外研究

4-OHT是有效的ER激活剂,相比于tamoxifen,它对雌激素受体有更高的亲和力。4-OHT具有较强的剂量和时间依赖式效应,能改变分离出来的大鼠心肌细胞的收缩功能[1]。4-HT可激活intein-Cas9突变体的靶向修饰效率[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MYDQdo9tcW[ncnH0bY9vKGG|c3H5 M13JWmlvcGmkaYTpc44hd2ZiZYP0do9o\W5vc4TpcZVt[XSnZDDNR2YuPyClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC53IH7N M3rQ[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl3NEi4NVcoRjl3NEi4NVc9N2F-
MCF7 NGC2TmxHfW6ldHnvckBie3OjeR?= MmriSYZn\WO2aY\lJIRwe2ViZn;yJHs{UF1vIHXzeJJi\GmxbDDh[4FqdnO2IIDyc4xq\mW{YYTpc44hd2ZiTVPGMVch[2WubIOsJGVEPTBiPTCwMlAxODB|IN88UU4> NIO2T4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[5OlgyLz5{N{[5OlgyRC:jPh?=
MCF7 NUfTWoRSTnWwY4Tpc44h[XO|YYm= NGjBe2Y1KGi{cx?= MkjyTY5lfWO2aX;uJI9nKEWUYXzwbIEh\GWpcnHkZZRqd25iaX6gbJVu[W5iTVPGO{Bk\WyuczDpckBxcGWwb3ygdoVlKG[{ZXWgVnBOUSCvZXTpeY0h[2:wdHHpcolv\yB3JTDjbIFz[2:jbDDk[Zh1emGwLYTy[YF1\WRiRlLTJIlv[3WkYYTl[EBnd3JiNDDodpMh[nliU2CxJIFv\CCjboTpMWVTKHKjYnLpeEBud26xY3;scoFtKGGwdHnic4R6KGKjc3XkJIlvNWOnbHygW4V{fGW{bjDhd5NigSxiQXP0bZZqfHliPTCwMlAxODFizszNMi=> M3Pvb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEi2OlI3Lz5|MEC4OlYzPjxxYU6=
MCF7 M4nIXWZ2dmO2aX;uJIF{e2G7 NI\J[pBG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NEA:KDBwMECwNVIh|ryPLh?= NWXKSnB5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4NlU6OzVpPkGyPFI2QTN3PD;hQi=>
MCF7 NVLvUHlySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYi4bYhmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyIE2gNE4xODB3IN88UU4> MlSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2MEWyPFYoRjJ{NEC1Nlg3RC:jPh?=
MCF7 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFSwU5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOsJGlEPTBiPTCwMlAxODV|NzFOwG0v NH\5eoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|AyOid-Mk[0NFcxOTJ:L3G+
MCF MnzISpVv[3Srb36gZZN{[Xl? NWHMcZZYSW62YXfvcol{fCCjY4Tpeol1gSCjdDDwdo9o\XO2ZYLvcoUhemWlZYD0c5IhcW5iaIXtZY4hVUOIIHPlcIx{KGG|c3Xzd4VlKGG|IHXzeJJi\GmxbD3pcoR2[2WmIILlZ4VxfG:{IILld5BwdnOnLDDJR|UxKD1iMD6wNFA4QTR|IN88UU4> NGX5ZW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|AyOid-Mk[0NFcxOTJ:L3G+
Ishikawa endometrial cells MXPGeY5kfGmxbjDhd5NigQ>? MWfB[49vcXO2IHHjeIl3cXS7IHHzJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGmwZIXjeIlwdiCrbjDJd4hqc2G5YTDlcoRwdWW2cnnhcEBk\WyuczDjc41x[XKnZDD0c{BGOixiRVO1NEA:KDBwMECwPEDPxE1w NYTsb3ZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWzPFAzODhpPkG1N|gxOjB6PD;hQi=>
MCF7 NX\ETmUzTnWwY4Tpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQheHKxbHnm[ZJifGmxbjDpckBpfW2jbjDNR2YuPyCkcnXhd5Qh[2GwY3XyJINmdGy|LDDJR|UxKD1iMD6wNFEyPyEQvF2u M3v5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlzNUS5OlMoRjlzNUS5OlM9N2F-
MCF7 M3rvdGZ2dmO2aX;uJIF{e2G7 Mn\2NlQhcHK| MVrBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQhfHKjboPjdolxfGmxbjDwdoVqdmO3YnH0[YQhd3[ncn7p[4h1KG[xbHzve4VlKGK7IHXzeJJw\2WwIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCmdXHsJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NEA:KDBwMECzJO69VS5? MkH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
Rosetta 2 DE3 NVmxSXV7TnWwY4Tpc44h[XO|YYm= NV3lRlBSOSCqch?= NV;M[29qTGm|cHzhZ4Vu\W62IH;mJHs{UF1vZYP0doFlcW:uIH\yc40hemWlb33ibY5idnRiaIXtZY4hVi22ZYLtbY5idCCKaYOteIFo\2WmIFXSZYxxcGFiTFLEJIhiemKxcnnu[{BEOzhzUz;DOFE4Wy:FNUOwV{BufXSjboSg[ZhxemW|c3XkJIlvKFKxc3X0eIEhOiCGRUOgZ49ueGW2ZX70JINmdGy|IHHmeIVzKDFiaIKgZpkhW1CDIHLpcoRqdmdiYYPzZZktKEmFNUCgQUAxNjByNDFOwG0v NVvQN3NPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPVY{QThpPkK4Nlk3Ozl6PD;hQi=>
insect cells NG\NdI1HfW6ldHnvckBie3OjeR?= NYjpSWg2UW6qaXLpeIlwdiCxZjDmcJVwem2xbnWgSXMzKGe{ZXXuJIJqdmSrbnegeI8hemWlb33ibY5idnRiZoXscEBt\W6pdHigbJVu[W5iRWLhcJBp[SCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGK7IH\seY9z\XOlZX7j[UBxd2yjcnn6ZZRqd25iYYPzZZktKEmFNUCgQUAxNjByNkK5JO69VS5? NULnfpdkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3N|UzOTRpPkK4O|M2OjF2PD;hQi=>
MCF-7-2a MVzGeY5kfGmxbjDhd5NigQ>? NH3uNllKdmirYnn0bY9vKG:oIHXzeJJi\GmxbDDpcoR2[2WmIHXzeJJw\2WwIILlZ4VxfG:{IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHnuJG1ETi15LULhJINmdGy|LDDJR|UxKD1iMD6wNFch|ryPLh?= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ5MkK0PUc,OTJ4N{KyOFk9N2F-
MCF7 M{PtTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUCyOEBpenN? MnHIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSByLkCwPFUh|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ5MkK1Okc,OTh{N{KyOVY9N2F-
MCF7 M4rndWZ2dmO2aX;uJIF{e2G7 NYLV[JNVUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgUWNHNTdiYoLlZZN1KHS3bX;yJINmdGy|IIXzbY5oKE2FRj23JIF{e2G7LDDJR|UxKD1iMD6wNFg2KM7:TT6= MmL1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
Ishikawa cells MlPsSpVv[3Srb36gZZN{[Xl? MXm3NkBpenN? NYHyRmJ6SW62YXfvcol{fCCjY4Tpeol1gSCjdDDld5Rzd2enbjDy[YNmeHSxcjDhcJBp[S:kZYThJIlvKGi3bXHuJGl{cGmtYYfhJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCjbHvhcIlv\SCyaH;zdIhifGG|ZTDhd5NigSxiSVO1NEA:KDBwMEGg{txONg>? NYDzZnFqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlY6OzFpPkK4OFI3QTNzPD;hQi=>
insect cells MlL5SpVv[3Srb36gZZN{[Xl? M2DCVGRqe3CuYXPlcYVvfCCxZjDmcJVwemW|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhcW6|ZXP0JINmdGy|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkCyJO69VS5? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh|NUG3Okc,OTh6M{WxO|Y9N2F-
MCF7 M2\CTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NF;rWHc2KGSjeYO= MoX5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC1JIRigXNuIFnDOVAhRSByLkCyPVEh|ryPLh?= M{jz[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OE[0PVI5Lz5{M{i2OFkzQDxxYU6=
GT1-7 NIK3R49HfW6ldHnvckBie3OjeR?= MUmyNEB1dyB{NDDodpM> NEHxN4NCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHnuJI1wfXOnIFfUNU04KGOnbHzzJIhiemKxcnnu[{Bj\XSjLXfhcIFkfG:|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iMUfi[ZRiNWW|dILh[IlwdCCrbnT1Z4VlKHKnc4DvcpNmKG2nYYP1doVlKGGodHXyJFIxKHSxIEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUCgQUAxNjB|M{Kg{txONg>? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRyMEKzPUc,Ojh2MECyN|k9N2F-
insect cells NXvsOnk6TnWwY4Tpc44h[XO|YYm= MlPkSIl{eGyjY3Xt[Y51KG:oIH\seY9z\XOlZXnuJIxi[mWuZXSg[ZN1emGmaX;sJIZzd21iaIXtZY4hemWlb33ibY5idnRiRWLhcJBp[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhcW6|ZXP0JINmdGy|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkC0JO69VS5? NVTueFVLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4N|UyPzZpPkG4PFM2OTd4PD;hQi=>
HEK293 MoOySpVv[3Srb36gZZN{[Xl? NHvPbFI{OCCvaX7z NXe3WWd1UW6qaXLpeIlwdiCxZjDHSnAufGGpZ3XkJIh2dWGwIGDMSFIh\XiycnXzd4VlKGmwIHj1cYFvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCyaH;zdIhifGmmeXzieZRidm:uLWvkPX0heHKxZIXjeIlwdiCjZoTldkA{OCCvaX7zJIJ6KG2jc4Ogd5Bm[3S{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDBwMES0JO69VS5? NEjzcI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGzOlk4PSd-MUmxN|Y6PzV:L3G+
HEK293 M{Pyb2Z2dmO2aX;uJIF{e2G7 M4n2UlEhcHJ? M2HoO2FvfGGpb37pd5Qh[WO2aY\peJkh[XRicnXjc41jcW6jboSgbJVu[W5iRWLhcJBp[SCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\XO2cnHkbY9tNWmwZIXj[YQhYU[SLX\1d4VlKFOUQ{GgZ49i[3SrdnH0c5IhemWlcoXpeI1mdnRibXXhd5Vz\WRiYX\0[ZIhOSCqcjDpckBxemW|ZX7j[UBw\iCFb3Xs[Y51\XKjennu[UBJKGK7IFLSSXQh[XO|YYmsJGlEPTBiPTCwMlA4KM7:TT6= M{PrTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 Mo\NRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWW3NkBpenN? MmLmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDld5Rzd2enbjDy[YNmeHSxcjDk[ZBmdmSnboSgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xNFch|ryPLh?= M1[weVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OEO1NVc3Lz5zOEizOVE4PjxxYU6=
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Ishikawa endometrial cells MoT4SpVv[3Srb36gZZN{[Xl? NHjaVphCdnSjZ3;ubZN1KGGldHn2bZR6KGG|IHnubIljcXSrb36gc4YhOSCwTTCxO{1j\XSjLXXzeJJi\GmxbDDzeIlufWyjdHXkJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGmwZIXjeIlwdiCrbjDJd4hqc2G5YTDlcoRwdWW2cnnhcEBk\WyuczygTWM2OCB;IECuOVEh|ryPLh?= NYPjeGN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWzPFAzODhpPkG1N|gxOjB6PD;hQi=>
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MCF7 NYPPWWtrTnWwY4Tpc44h[XO|YYm= M2LjUlUhfU1? NVfYWFd5OjRiaILz M4fJe2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIFWySlEhdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= Mnn2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 M1LxdWZ2dmO2aX;uJIF{e2G7 M3WzVFUhfU1? NYXTNpRVOjRiaILz Mnm4RY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiTVvJOlchdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= NVLk[YlIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 ; 

PubMed: 26163823     


LNCaP-Raf:ER cells were treated with increasing doses of 4-hydroxytamoxifen for 2 days. The bottom panel indicates densitometry of MEK1 and MEK2 signals. Data (mean ± standard error) are from two independent experiments. Pearson’s r = 0.823 for MEK1 and −0.673 for MEK2. 

26163823
Growth inhibition assay
Cell viability; 

PubMed: 26014809     


Dose-dependent effect of 4-hydroxytamoxifen on survival of T47D, MCF-7 and BT-474 cell lines after 96 h of treatment. Control samples were treated with appropriate concentrations of DMSO. Viability was assayed by MTT method.

26014809

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

- 合并
  • Cell lines: 成年大鼠和小鼠心肌细胞
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 礛
  • Incubation Time: 15-45 min
  • Method:

    细胞置于含有4OHT的台式液中,孵育温度为36 ± 1°C,以0.2Hz的频率予以刺激,测量其肌节长度。


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: SD大鼠(Sprague-Dawley rats)
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 387.51
化学式

C26H29NO2

CAS号 68392-35-8
储存条件 粉状
溶于溶剂
别名 Afimoxifene

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Estrogen/progestogen Receptor Signaling Pathway Map

相关Estrogen/progestogen Receptor产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID