4-Hydroxytamoxifen (Afimoxifene)

For research use only. Not for use in humans.

目录号:S7827 别名: Afimoxifene 中文名称:4-羟基三苯氧胺

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1057.45 现货
RMB 958.6 现货
RMB 4070.46 现货
有超大折扣
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客户使用Selleck生产的4-Hydroxytamoxifen (Afimoxifene)发表文献13篇:

客户使用该产品的1个实验数据:

  • CDK4/6 inhibitor resistance promotes diminished ER expression and activity. (a and b) Proliferation of MCF-7 and MR cells in the presence of different concentrations of ICI (a) or 4-hydroxytamoxifen (4-OHT) (b) was measured by the alamarBlue assay and plotted as % inhibition of proliferation against log concentration of inhibitor. Each data point represents the average value±s.d. of six replicates obtained in three independent experiments.

    Oncogene, 2016, 36(16):2255-2264. 4-Hydroxytamoxifen (Afimoxifene) purchased from Selleck.

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

生物活性

产品描述 4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。
体外研究

4-OHT是有效的ER激活剂,相比于tamoxifen,它对雌激素受体有更高的亲和力。4-OHT具有较强的剂量和时间依赖式效应,能改变分离出来的大鼠心肌细胞的收缩功能[1]。4-HT可激活intein-Cas9突变体的靶向修饰效率[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells M4P6c3Bzd2yrZnXyZZRqd25iYYPzZZk> NV73UodYUW6qaXLpeIlwdiCxZjDld5Rzd2enbj3zeIlufWyjdHXkJG1ETi15IHPlcIwheHKxbHnm[ZJifGmxbjygTWM2OD1yLkWgcm0> NWrBU|VQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUW0PFgyPyd-OUW0PFgyPzxxYU6=
MCF7 NHfGW2pHfW6ldHnvckBie3OjeR?= MVrF[oZm[3SrdnWg[I9{\SCob4KgX|NJZS1iZYP0doFlcW:uIHHnZYlve3RicILvcIln\XKjdHnvckBw\iCPQ1[tO{Bk\WyuczygSWM2OCB;IECuNFAxODNizszNMi=> MmXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4OU[4NUc,Ojd4OU[4NVww[T5?
MCF7 NV3NUG9UTnWwY4Tpc44h[XO|YYm= MlLlOEBpenN? NVLSe29sUW6mdXP0bY9vKG:oIFXSZYxxcGFiZHXndoFl[XSrb36gbY4hcHWvYX6gUWNHPyClZXzsd{BqdiCyaHXuc4whemWmIH\y[YUhWlCPSTDt[YRqfW1iY3;ueIFqdmmwZzC1KUBkcGG{Y3;hcEBl\Xi2cnHuMZRz\WG2ZXSgSmJUKGmwY4XiZZRm\CCob4KgOEBpenNiYomgV3AyKGGwZDDhcpRqNUWUIILhZoJqfCCvb37vZ49tdmGuIHHueIljd2S7IHLhd4VlKGmwLXPlcIwhX2W|dHXyckBie3OjeTygRYN1cX[rdImgQUAxNjByMEGg{txONg>? NFLsZ2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC4OlYzPid-M{CwPFY3OjZ:L3G+
MCF7 NWq3epRQTnWwY4Tpc44h[XO|YYm= NEm1eItG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NEA:KDBwMECwNVIh|ryPLh?= MoDrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
MCF7 NF[wTo9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Ml33RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wNFA2KM7:TT6= M2f0NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEC1Nlg3Lz5{MkSwOVI5PjxxYU6=
MCF7 MlPQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2L4NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczygTWM2OCB;IECuNFAxPTN5IN88UU4> MlTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEewNVIoRjJ4NEC3NFEzRC:jPh?=
MCF NXf1doZqTnWwY4Tpc44h[XO|YYm= NEHoeGtCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IIDyc4dme3Sncn;u[UBz\WOncITvdkBqdiCqdX3hckBOS0ZiY3XscJMh[XO|ZYPz[YQh[XNiZYP0doFlcW:uLXnu[JVk\WRicnXj[ZB1d3JicnXzdI9ve2VuIFnDOVAhRSByLkCwNFc6PDNizszNMi=> NF2zb3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|AyOid-Mk[0NFcxOTJ:L3G+
Ishikawa endometrial cells M4jwVWZ2dmO2aX;uJIF{e2G7 MXLB[49vcXO2IHHjeIl3cXS7IHHzJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGmwZIXjeIlwdiCrbjDJd4hqc2G5YTDlcoRwdWW2cnnhcEBk\WyuczDjc41x[XKnZDD0c{BGOixiRVO1NEA:KDBwMECwPEDPxE1w MlvLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV|OECyNFgoRjF3M{iwNlA5RC:jPh?=
MCF7 MnzKSpVv[3Srb36gZZN{[Xl? M2LsW2lvcGmkaYTpc44hd2ZiZYP0do9o\W5vaX7keYNm\CCycn;sbYZmemG2aX;uJIlvKGi3bXHuJG1ETi15IHLy[YF{fCClYX7j[ZIh[2WubIOsJGlEPTBiPTCwMlAxOTF5IN88UU4> MmrxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTF3NEm2N{c,QTF3NEm2N|ww[T5?
MCF7 MX3GeY5kfGmxbjDhd5NigQ>? MoH2NlQhcHK| M1jWdGFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiZYP0do9o\W5vaX7keYNm\CC2cnHud4NzcXC2aX;uJJBz\WmwY4XiZZRm\CCxdnXycolocHRiZn;scI94\WRiYomg[ZN1em:pZX6gZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IHT1ZYwhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxKD1iMD6wNFMh|ryPLh?= M1rnSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mkm2N|k5Lz5{OEK5OlM6QDxxYU6=
Rosetta 2 DE3 NF3iOZJHfW6ldHnvckBie3OjeR?= NET2fZUyKGi{ MWjEbZNxdGGlZX3lcpQhd2ZiW{PIYU1me3S{YXTpc4wh\nKxbTDy[YNwdWKrbnHueEBpfW2jbjDOMZRmem2rbnHsJGhqey22YXfn[YQhTVKjbIDoZUBNSkRiaHHyZo9zcW6pIFOzPFFUN0N2MUfTM2M2OzCVIH31eIFvfCCneIDy[ZN{\WRiaX6gVo9{\XS2YTCyJGRGOyClb33w[ZRmdnRiY3XscJMh[W[2ZYKgNUBpeiCkeTDTVGEh[mmwZHnu[{Bie3OjeTygTWM2OCB;IECuNFA1KM7:TT6= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ7NkO5PEc,Ojh{OU[zPVg9N2F-
insect cells NHPuPIdHfW6ldHnvckBie3OjeR?= MX3Jcohq[mm2aX;uJI9nKG[udX;ycY9v\SCHU{Kg[5Jm\W5iYnnu[Ilv\yC2bzDy[YNwdWKrbnHueEBnfWyuIHzlcod1cCCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OCB;IECuNFA3OjlizszNMi=> M2K4fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{O1NlE1Lz5{OEezOVIyPDxxYU6=
MCF-7-2a MnjUSpVv[3Srb36gZZN{[Xl? Mlu4TY5pcWKrdHnvckBw\iCnc4TyZYRqd2xiaX7keYNm\CCnc4Tyc4dmdiC{ZXPldJRweiC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCrbjDNR2YuPy1{YTDj[YxteyxiSVO1NEA:KDBwMEC3JO69VS5? NGTFfmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[3NlI1QSd-MUK2O|IzPDl:L3G+
MCF7 NFvWO4FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYnXTJo4OjRiaILz NXPGVXE1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTBiPTCwMlAxQDVizszNMi=> NFXvSmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK3NlI2Pid-MUiyO|IzPTZ:L3G+
MCF7 MX;GeY5kfGmxbjDhd5NigQ>? M37JOGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiSVO1NEA:KDBwMEC4OUDPxE1w MkGyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
Ishikawa cells M4\FUWZ2dmO2aX;uJIF{e2G7 MmTEO|IhcHK| MUHBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGW|dILv[4VvKHKnY3XweI9zKGGucHjhM4JmfGFiaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGG|c3H5MEBKSzVyIE2gNE4xOSEQvF2u MnPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5N|EoRjJ6NEK2PVMyRC:jPh?=
insect cells NXr0cYM1TnWwY4Tpc44h[XO|YYm= M1:yZ2Rqe3CuYXPlcYVvfCCxZjDmcJVwemW|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhcW6|ZXP0JINmdGy|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkCyJO69VS5? NVrJN446RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4N|UyPzZpPkG4PFM2OTd4PD;hQi=>
MCF7 MkPqR5l1d3SxeHnjbZR6KGG|c3H5 M3vjR|Uh\GG7cx?= NXPVNFFSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA2KGSjeYOsJGlEPTBiPTCwMlAzQTFizszNMi=> NGSw[XQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i2OFkzQCd-MkO4OlQ6Ojh:L3G+
GT1-7 NWfYNZVlTnWwY4Tpc44h[XO|YYm= NInsdpAzOCC2bzCyOEBpenN? NIDqUpJCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHnuJI1wfXOnIFfUNU04KGOnbHzzJIhiemKxcnnu[{Bj\XSjLXfhcIFkfG:|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iMUfi[ZRiNWW|dILh[IlwdCCrbnT1Z4VlKHKnc4DvcpNmKG2nYYP1doVlKGGodHXyJFIxKHSxIEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUCgQUAxNjB|M{Kg{txONg>? MkLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MECyN|koRjJ6NECwNlM6RC:jPh?=
insect cells NYL6bJNiTnWwY4Tpc44h[XO|YYm= M2rCNmRqe3CuYXPlcYVvfCCxZjDmcJVwemW|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZYxxcGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR|UxKD1iMD6wOEDPxE1w NEjVXWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEizOVE4Pid-MUi4N|UyPzZ:L3G+
HEK293 MX;GeY5kfGmxbjDhd5NigQ>? NUfpNGlVOzBibXnudy=> NWPneFBPUW6qaXLpeIlwdiCxZjDHSnAufGGpZ3XkJIh2dWGwIGDMSFIh\XiycnXzd4VlKGmwIHj1cYFvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCyaH;zdIhifGmmeXzieZRidm:uLWvkPX0heHKxZIXjeIlwdiCjZoTldkA{OCCvaX7zJIJ6KG2jc4Ogd5Bm[3S{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDBwMES0JO69VS5? NWnwfVVSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxN|Y6PzVpPkG5NVM3QTd3PD;hQi=>
HEK293 NX;wbm5{TnWwY4Tpc44h[XO|YYm= MYWxJIhz MkfNRY51[WexbnnzeEBi[3Srdnn0fUBifCC{ZXPvcYJqdmGwdDDoeY1idiCHUnHsdIhiKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{YXTpc4wucW6mdXPl[EB[TlBvZoXz[YQhW1KFMTDjc4FkfGm4YYTvdkBz\WO{dXn0cYVvfCCvZXHzeZJm\CCjZoTldkAyKGi{IHnuJJBz\XOnbnPlJI9nKEOxZXzlcpRmemG8aX7lJGgh[nliQmLFWEBie3OjeTygTWM2OCB;IECuNFch|ryPLh?= NV\he3V6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>
MCF7 NWDUfJRVSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3joOVczKGi{cx?= MnjlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDld5Rzd2enbjDy[YNmeHSxcjDk[ZBmdmSnboSgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xNFch|ryPLh?= Mo[3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6M{WxO|YoRjF6OEO1NVc3RC:jPh?=
MCF7 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2q5TFczKGi{cx?= MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHS{eYDhckBjdHWnIHHzd4F6NCCJSUWwJF0hOC5zMEeg{txONg>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd|NUiyPUc,OjN5M{W4Nlk9N2F-
MCF7 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmnFO|IhcHK| NFrkcIpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGVTNWSncHXu[IVvfCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjFzIN88UU4> MmiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5N|EoRjJ6NEK2PVMyRC:jPh?=
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MDA-MB-231 NUP3OXlESW62aXPhcoNmeiCjc4PhfS=> MW[0PEBpenN? M1\CV2FvfGmlYX7j[ZIh[WejaX7zeEBpfW2jbjDFVk1xd3OrdHn2[UBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC1MlQh|ryPLh?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2NkG0OUc,OjR7NE[xOFU9N2F-
MCF-7 MoH4R5l1d3SxeHnjbZR6KGG|c3H5 M1K2VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2FRj23JINmdGy|IHnuJJRp\SCjYoPlcoNmKG:oIEGgeW0hTTJiKHXzeJJi\GmxbDmsJGN6fG:2b4jpZ4l1gSB;IE[g{txONg>? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86ODh7M{OyK|46ODh7M{OyQE9iRg>?
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MCF-7 M4S5eGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGPITFlEgXSxc4TheIlkcXS7IHHnZYlve3RiTVPGMVch[2WubIOgbY4hfGinIIDy[ZNmdmOnIH;mJFEhfU2xbHHyJGUzKCinc4TyZYRqd2xrLDDJR|UxKD1iODFOwG0v Mk\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTB6OUOzNkc,QTB6OUOzNlww[T5?
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MCF-7 NYnoT4RkS3m2b4TvfIlkcXS7IHHzd4F6 NV\JN5lFS3m2b4TvfIlkcXS7IHHnZYlve3RiTVPGMVch[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMTD1UUBGOiBqZYP0doFlcW:uKTygR5l1d3SxeHnjbZR6KD1iOT60JO69VS5? NH\FXo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MEi5N|MzLz57MEi5N|MzRC:jPh?=
MDA-MB-231 NIrwTVRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NV\EbpMzOjRiaILz MnLuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOC52IN88UU4> Mm[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOEmwOVUoRjJ2MUi5NFU2RC:jPh?=
MDA-MB-453 Mn7mRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnqyO|IhcHK| NYfXfm4zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEWzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD60JO69VS5? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDVyNkW4Nkc,Ojh3ME[1PFI9N2F-
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MCF7 Mk\XRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWjRbZhxPzJiaILz MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvPiEQvF2u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl7M{K2PUc,OjV7OUOyOlk9N2F-
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MCF7 MkPVSpVv[3Srb36gZZN{[Xl? MUe1JJVO NVTLdlBDOjRiaILz MmPPRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiVF\GNUBuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG|ZXSgVnQueVCFUjDhcoFtgXOrcx?= NHW5V289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 M136SWZ2dmO2aX;uJIF{e2G7 NYLaWYhyPSC3TR?= M2fkd|I1KGi{cx?= MX;BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCJUlXCNUBuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG|ZXSgVnQueVCFUjDhcoFtgXOrcx?= NHSwWVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 NV7MPIpTTnWwY4Tpc44h[XO|YYm= MnzVOUB2VQ>? M3LNTlI1KGi{cx?= MVnBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCPWVLMNkBuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG|ZXSgVnQueVCFUjDhcoFtgXOrcx?= M364UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
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MCF7 MYTGeY5kfGmxbjDhd5NigQ>? MliwOUB2VQ>? NVu5T|JlOjRiaILz M3K2U2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIFPER|YhdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= MnzjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 M3TFZWZ2dmO2aX;uJIF{e2G7 NX;hPJFPPSC3TR?= MWWyOEBpenN? MXrBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCHMl[xJI1TVkFiZYjwdoV{e2mxbjDheEA2KHWPIHHmeIVzKDJ2IHjyd{BjgSCTSVH6c4whemWjZ3XueEBj[XOnZDDSWE1yWEOUIHHuZYx6e2m| MoTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 NYTKOZNbTnWwY4Tpc44h[XO|YYm= NIfWdlI2KHWP NYLBdpc1OjRiaILz MV7BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCPS1m2O{BuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG|ZXSgVnQueVCFUjDhcoFtgXOrcx?= NXPib3h3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 ; 

PubMed: 26163823     


LNCaP-Raf:ER cells were treated with increasing doses of 4-hydroxytamoxifen for 2 days. The bottom panel indicates densitometry of MEK1 and MEK2 signals. Data (mean ± standard error) are from two independent experiments. Pearson’s r = 0.823 for MEK1 and −0.673 for MEK2. 

26163823
Growth inhibition assay
Cell viability; 

PubMed: 26014809     


Dose-dependent effect of 4-hydroxytamoxifen on survival of T47D, MCF-7 and BT-474 cell lines after 96 h of treatment. Control samples were treated with appropriate concentrations of DMSO. Viability was assayed by MTT method.

26014809

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

- 合并
  • Cell lines: 成年大鼠和小鼠心肌细胞
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 礛
  • Incubation Time: 15-45 min
  • Method:

    细胞置于含有4OHT的台式液中,孵育温度为36 ± 1°C,以0.2Hz的频率予以刺激,测量其肌节长度。


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: SD大鼠(Sprague-Dawley rats)
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 387.51
化学式

C26H29NO2

CAS号 68392-35-8
储存条件 粉状
溶于溶剂
别名 Afimoxifene

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05133674 Not yet recruiting Drug: Tamoxifen 20 mg Breast Cancer|Breast Carcinoma|Breast Tumors|Cancer of Breast|Malignant Neoplasm of Breast Karolinska University Hospital January 10 2022 Phase 2
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Estrogen/progestogen Receptor Signaling Pathway Map

相关Estrogen/progestogen Receptor产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID