4-Hydroxytamoxifen (Afimoxifene)

For research use only. Not for use in humans.

目录号:S7827 别名: Afimoxifene 中文名称:4-羟基三苯氧胺

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1057.45 现货
RMB 958.6 现货
RMB 4070.46 现货
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客户使用Selleck生产的4-Hydroxytamoxifen (Afimoxifene)发表文献9篇:

客户使用该产品的1个实验数据:

  • CDK4/6 inhibitor resistance promotes diminished ER expression and activity. (a and b) Proliferation of MCF-7 and MR cells in the presence of different concentrations of ICI (a) or 4-hydroxytamoxifen (4-OHT) (b) was measured by the alamarBlue assay and plotted as % inhibition of proliferation against log concentration of inhibitor. Each data point represents the average value±s.d. of six replicates obtained in three independent experiments.

    Oncogene, 2016, 36(16):2255-2264. 4-Hydroxytamoxifen (Afimoxifene) purchased from Selleck.

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

生物活性

产品描述 4-Hydroxytamoxifen (Afimoxifene) 是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛。4-HT可激活intein-Cas9突变体的靶向修饰效率。
体外研究

4-OHT是有效的ER激活剂,相比于tamoxifen,它对雌激素受体有更高的亲和力。4-OHT具有较强的剂量和时间依赖式效应,能改变分离出来的大鼠心肌细胞的收缩功能[1]。4-HT可激活intein-Cas9突变体的靶向修饰效率[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells M2jnWHBzd2yrZnXyZZRqd25iYYPzZZk> NHS5dHVKdmirYnn0bY9vKG:oIHXzeJJw\2WwLYP0bY12dGG2ZXSgUWNHNTdiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwNTDuUS=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PTR6OEG3K|46PTR6OEG3QE9iRg>?
MCF7 NHXm[ZRHfW6ldHnvckBie3OjeR?= NHXzV5lG\m[nY4TpeoUh\G:|ZTDmc5IhYzOKXT2g[ZN1emGmaX;sJIFo[Wmwc4SgdJJwdGmoZYLheIlwdiCxZjDNR2YuPyClZXzsd{whTUN3MDC9JFAvODByMEOg{txONg>? NEi0bpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[5OlgyLz5{N{[5OlgyRC:jPh?=
MCF7 NFXsTWxHfW6ldHnvckBie3OjeR?= MYm0JIhzew>? MlLiTY5lfWO2aX;uJI9nKEWUYXzwbIEh\GWpcnHkZZRqd25iaX6gbJVu[W5iTVPGO{Bk\WyuczDpckBxcGWwb3ygdoVlKG[{ZXWgVnBOUSCvZXTpeY0h[2:wdHHpcolv\yB3JTDjbIFz[2:jbDDk[Zh1emGwLYTy[YF1\WRiRlLTJIlv[3WkYYTl[EBnd3JiNDDodpMh[nliU2CxJIFv\CCjboTpMWVTKHKjYnLpeEBud26xY3;scoFtKGGwdHnic4R6KGKjc3XkJIlvNWOnbHygW4V{fGW{bjDhd5NigSxiQXP0bZZqfHliPTCwMlAxODFizszNMi=> NFPrc|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC4OlYzPid-M{CwPFY3OjZ:L3G+
MCF7 M2rTc2Z2dmO2aX;uJIF{e2G7 NXvYSmFyTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFXDOVAhRSByLkCwNFEzKM7:TT6= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh{NUmzOUc,OTJ6MkW5N|U9N2F-
MCF7 M37yZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXzvdlF3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyIE2gNE4xODB3IN88UU4> Ml\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2MEWyPFYoRjJ{NEC1Nlg3RC:jPh?=
MCF7 Mo\iRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3ryO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczygTWM2OCB;IECuNFAxPTN5IN88UU4> Mmr4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEewNVIoRjJ4NEC3NFEzRC:jPh?=
MCF NUDTVJg5TnWwY4Tpc44h[XO|YYm= MorHRY51[WexbnnzeEBi[3Srdnn0fUBifCCycn;n[ZN1\XKxbnWgdoVk\XC2b4KgbY4hcHWvYX6gUWNHKGOnbHzzJIF{e2W|c3XkJIF{KGW|dILh[IlwdC2rbnT1Z4VlKHKnY3XweI9zKHKnc4DvcpNmNCCLQ{WwJF0hOC5yMEC3PVQ{KM7:TT6= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{CxNkc,OjZ2MEewNVI9N2F-
Ishikawa endometrial cells MX\GeY5kfGmxbjDhd5NigQ>? MonZRYdwdmm|dDDhZ5Rqfmm2eTDhd{BidGujbHnu[UBxcG:|cHjheIF{\SCrbnT1Z5Rqd25iaX6gTZNpcWujd3Gg[Y5ld22ndILpZYwh[2WubIOgZ49ueGG{ZXSgeI8hTTJuIFXDOVAhRSByLkCwNFgh|ryPLh?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTN6MEKwPEc,OTV|OECyNFg9N2F-
MCF7 M2HDdWZ2dmO2aX;uJIF{e2G7 M1LWS2lvcGmkaYTpc44hd2ZiZYP0do9o\W5vaX7keYNm\CCycn;sbYZmemG2aX;uJIlvKGi3bXHuJG1ETi15IHLy[YF{fCClYX7j[ZIh[2WubIOsJGlEPTBiPTCwMlAxOTF5IN88UU4> NHzJdWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MUW0PVY{Lz57MUW0PVY{RC:jPh?=
MCF7 NWHaemFmTnWwY4Tpc44h[XO|YYm= M3jtTFI1KGi{cx?= MWfBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQhfHKjboPjdolxfGmxbjDwdoVqdmO3YnH0[YQhd3[ncn7p[4h1KG[xbHzve4VlKGK7IHXzeJJw\2WwIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCmdXHsJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NEA:KDBwMECzJO69VS5? NX7mdFJ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPVY{QThpPkK4Nlk3Ozl6PD;hQi=>
Rosetta 2 DE3 MWPGeY5kfGmxbjDhd5NigQ>? MV[xJIhz MUDEbZNxdGGlZX3lcpQhd2ZiW{PIYU1me3S{YXTpc4wh\nKxbTDy[YNwdWKrbnHueEBpfW2jbjDOMZRmem2rbnHsJGhqey22YXfn[YQhTVKjbIDoZUBNSkRiaHHyZo9zcW6pIFOzPFFUN0N2MUfTM2M2OzCVIH31eIFvfCCneIDy[ZN{\WRiaX6gVo9{\XS2YTCyJGRGOyClb33w[ZRmdnRiY3XscJMh[W[2ZYKgNUBpeiCkeTDTVGEh[mmwZHnu[{Bie3OjeTygTWM2OCB;IECuNFA1KM7:TT6= MnzNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
insect cells NWmxN2Y2TnWwY4Tpc44h[XO|YYm= NUS4dHJoUW6qaXLpeIlwdiCxZjDmcJVwem2xbnWgSXMzKGe{ZXXuJIJqdmSrbnegeI8hemWlb33ibY5idnRiZoXscEBt\W6pdHigbJVu[W5iRWLhcJBp[SCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGK7IH\seY9z\XOlZX7j[UBxd2yjcnn6ZZRqd25iYYPzZZktKEmFNUCgQUAxNjByNkK5JO69VS5? M1uyNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{O1NlE1Lz5{OEezOVIyPDxxYU6=
MCF-7-2a NGPqVJlHfW6ldHnvckBie3OjeR?= NEPtTWpKdmirYnn0bY9vKG:oIHXzeJJi\GmxbDDpcoR2[2WmIHXzeJJw\2WwIILlZ4VxfG:{IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHnuJG1ETi15LULhJINmdGy|LDDJR|UxKD1iMD6wNFch|ryPLh?= NWTCeHNERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2O|IzPDlpPkGyOlczOjR7PD;hQi=>
MCF7 M3rWTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWjDTG57OjRiaILz NV7IVm5pSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTBiPTCwMlAxQDVizszNMi=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ5MkK1Okc,OTh{N{KyOVY9N2F-
MCF7 NYHGTW5FTnWwY4Tpc44h[XO|YYm= MUTJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCPQ1[tO{BjemWjc4SgeJVud3JiY3XscJMhfXOrbnegUWNHNTdiYYPzZZktKEmFNUCgQUAxNjByOEWg{txONg>? NEHERpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkiyOVk{PSd-MUK4NlU6OzV:L3G+
Ishikawa cells M1e4VmZ2dmO2aX;uJIF{e2G7 MnriO|IhcHK| MmLqRY51[WexbnnzeEBi[3Srdnn0fUBifCCnc4Tyc4dmdiC{ZXPldJRweiCjbIDoZU9j\XSjIHnuJIh2dWGwIFnzbIls[XejIHPlcIx{KGGodHXyJFczKGi{czDifUBidGujbHnu[UBxcG:|cHjheIF{\SCjc4PhfUwhUUN3MDC9JFAvODFizszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{NkmzNUc,Ojh2Mk[5N|E9N2F-
insect cells MmOySpVv[3Srb36gZZN{[Xl? MX3EbZNxdGGlZX3lcpQhd2ZiZnz1c5Jme2OnaX6gcIFj\WynZDDld5Rz[WSrb3yg[pJwdSCqdX3hckBz\WOxbXLpcoFvfCCHUnLleIEh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyCkeTDmcJVwemW|Y3XuZ4UheG:uYYLpfoF1cW:wIHHzd4F6NCCLQ{WwJF0hOC5yMjFOwG0v MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh|NUG3Okc,OTh6M{WxO|Y9N2F-
MCF7 NGrvdndEgXSxdH;4bYNqfHliYYPzZZk> MVO1JIRigXN? M3\kdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOUBl[Xm|LDDJR|UxKD1iMD6wNlkyKM7:TT6= NV7re3ZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OlQ6OjhpPkKzPFY1QTJ6PD;hQi=>
GT1-7 Mkj6SpVv[3Srb36gZZN{[Xl? M1vnSlIxKHSxIEK0JIhzew>? NH7QSFFCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHnuJI1wfXOnIFfUNU04KGOnbHzzJIhiemKxcnnu[{Bj\XSjLXfhcIFkfG:|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iMUfi[ZRiNWW|dILh[IlwdCCrbnT1Z4VlKHKnc4DvcpNmKG2nYYP1doVlKGGodHXyJFIxKHSxIEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUCgQUAxNjB|M{Kg{txONg>? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRyMEKzPUc,Ojh2MECyN|k9N2F-
insect cells M3K4NmZ2dmO2aX;uJIF{e2G7 MYTEbZNxdGGlZX3lcpQhd2ZiZnz1c5Jme2OnaX6gcIFj\WynZDDld5Rz[WSrb3yg[pJwdSCqdX3hckBz\WOxbXLpcoFvfCCHUnHsdIhiKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNiYomg[ox2d3Knc3PlcoNmKHCxbHHybZpifGmxbjDhd5NigSxiSVO1NEA:KDBwMESg{txONg>? MnTjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6M{WxO|YoRjF6OEO1NVc3RC:jPh?=
HEK293 MUTGeY5kfGmxbjDhd5NigQ>? MX6zNEBucW6| NY\od2p6UW6qaXLpeIlwdiCxZjDHSnAufGGpZ3XkJIh2dWGwIGDMSFIh\XiycnXzd4VlKGmwIHj1cYFvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCyaH;zdIhifGmmeXzieZRidm:uLWvkPX0heHKxZIXjeIlwdiCjZoTldkA{OCCvaX7zJIJ6KG2jc4Ogd5Bm[3S{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDBwMES0JO69VS5? NGm0N4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGzOlk4PSd-MUmxN|Y6PzV:L3G+
HEK293 MXLGeY5kfGmxbjDhd5NigQ>? Mnq5NUBpeg>? MYLBcpRi\2:waYP0JIFkfGm4aYT5JIF1KHKnY3;tZolv[W62IHj1cYFvKEWUYXzwbIEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKjZHnvcE1qdmS3Y3XkJHlHWC2odYPl[EBUWkNzIHPvZYN1cX[jdH;yJJJm[3K3aYTt[Y51KG2nYYP1doVlKGGodHXyJFEhcHJiaX6gdJJme2WwY3Wgc4YhS2:nbHXueIVz[XqrbnWgTEBjgSCEUlXUJIF{e2G7LDDJR|UxKD1iMD6wO{DPxE1w Mnf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 MkKzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn;GO|IhcHK| NFnKNWlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuJJJm[2WydH;yJIRmeGWwZHXueEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlExPyEQvF2u NIS4S|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEizOVE4Pid-MUi4N|UyPzZ:L3G+
MCF7 NGWzXYpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mlu5O|IhcHK| MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHS{eYDhckBjdHWnIHHzd4F6NCCJSUWwJF0hOC5zMEeg{txONg>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd|NUiyPUc,OjN5M{W4Nlk9N2F-
MCF7 Mnq1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWC3NkBpenN? MnPXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDFVk1l\XCnbnTlcpQhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4yOSEQvF2u MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{NkmzNUc,Ojh2Mk[5N|E9N2F-
T47D NIDUTlJEgXSxdH;4bYNqfHliYYPzZZk> NG\BZZA2KGSjeYO= NFTq[YtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFUh\GG7czygTWM2OCB;IECuNlEh|ryPLh?= NWnQNWFPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OlQ6OjhpPkKzPFY1QTJ6PD;hQi=>
Ishikawa endometrial cells M3v6WGZ2dmO2aX;uJIF{e2G7 NX7ycYdlSW62YXfvcol{fCCjY4Tpeol1gSCjczDpcohq[mm2aX;uJI9nKDFibl2gNVcu[mW2YT3ld5Rz[WSrb3ygd5RqdXWuYYTl[EBidGujbHnu[UBxcG:|cHjheIF{\SCrbnT1Z5Rqd25iaX6gTZNpcWujd3Gg[Y5ld22ndILpZYwh[2WubIOsJGlEPTBiPTCwMlUyKM7:TT6= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTN6MEKwPEc,OTV|OECyNFg9N2F-
CV1 MVPGeY5kfGmxbjDhd5NigQ>? MUe0OUBpenN? MVPJcpZmenOnIHHnc45qe3RiYXP0bZZqfHliYYSgS2FNPC2GTlGgZolv\GmwZzDkc41icW5vZoXz[YQhdW:3c3WgSXJT\2GvbXGgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBEXjFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gdoVk\XC2b4KgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHHmeIVzKDR3IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlYh|ryPLh?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF6OUO5N{c,OjhzOEmzPVM9N2F-
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MCF7 NV24OGtXTnWwY4Tpc44h[XO|YYm= NIe3VW82KHWP MoThNlQhcHK| MUXBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iCPWVOgcXJPSSCneIDy[ZN{cW:wIHH0JFUhfU1iYX\0[ZIhOjRiaILzJIJ6KFGLQYrvcEBz\WGpZX70JIJie2WmIGLUMZFRS1JiYX7hcJl{cXN? NHv5R4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 Mnv0SpVv[3Srb36gZZN{[Xl? NUPoe3hiPSC3TR?= NYPGT|VyOjRiaILz NEHOXm5CdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDUSmYyKG2UTlGg[ZhxemW|c3nvckBifCB3IIXNJIFnfGW{IEK0JIhzeyCkeTDRTWF7d2xicnXh[4VvfCCkYYPl[EBTXC2zUFPSJIFv[Wy7c3nz NHTMUlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 MljISpVv[3Srb36gZZN{[Xl? MUO1JJVO MmezNlQhcHK| Ml\CRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiR2LFRlEhdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= NHnzeJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 NV3PSFJiTnWwY4Tpc44h[XO|YYm= NI\ZbYU2KHWP NF7QfWMzPCCqcoO= NIPwPXFCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDNXWJNOiCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> Mlj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 MnewSpVv[3Srb36gZZN{[Xl? MnLWOUB2VQ>? MnnzNlQhcHK| NFjoeZhCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDDR25FOSCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> M4DNbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 MmXLSpVv[3Srb36gZZN{[Xl? MlrUOUB2VQ>? NXzp[otXOjRiaILz NUfjOmp1SW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoFteGijIHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhe3WycILld5Nqd25ib3[gR2REPiCvUl7BJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCyOEBpenNiYomgVWlCgm:uIILlZYdmdnRiYnHz[YQhWlRvcWDDVkBidmGueYPpdy=> NF34SoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 NFX1bXpHfW6ldHnvckBie3OjeR?= NU\sbHJ2PSC3TR?= NVvN[XYyOjRiaILz MomyRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiRULGNUBuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG|ZXSgVnQueVCFUjDhcoFtgXOrcx?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5OE[wPUc,OzByN{i2NFk9N2F-
MCF7 NVfl[WdmTnWwY4Tpc44h[XO|YYm= NFPmSYU2KHWP NILJZWMzPCCqcoO= Mm\jRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiTVvJOlchdVKQQTDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGHJRZpwdCC{ZXHn[Y51KGKjc3XkJHJVNXGSQ2KgZY5idHm|aYO= NUHzdlRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO|g3ODlpPkOwNFc5PjB7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 ; 

PubMed: 26163823     


LNCaP-Raf:ER cells were treated with increasing doses of 4-hydroxytamoxifen for 2 days. The bottom panel indicates densitometry of MEK1 and MEK2 signals. Data (mean ± standard error) are from two independent experiments. Pearson’s r = 0.823 for MEK1 and −0.673 for MEK2. 

26163823
Growth inhibition assay
Cell viability; 

PubMed: 26014809     


Dose-dependent effect of 4-hydroxytamoxifen on survival of T47D, MCF-7 and BT-474 cell lines after 96 h of treatment. Control samples were treated with appropriate concentrations of DMSO. Viability was assayed by MTT method.

26014809

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

- 合并
  • Cell lines: 成年大鼠和小鼠心肌细胞
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 礛
  • Incubation Time: 15-45 min
  • Method:

    细胞置于含有4OHT的台式液中,孵育温度为36 ± 1°C,以0.2Hz的频率予以刺激,测量其肌节长度。


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: SD大鼠(Sprague-Dawley rats)
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 387.51
化学式

C26H29NO2

CAS号 68392-35-8
储存条件 粉状
溶于溶剂
别名 Afimoxifene

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Estrogen/progestogen Receptor Signaling Pathway Map

相关Estrogen/progestogen Receptor产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID