Docetaxel

别名: NSC 628503,RP56976 中文名称:多西他赛,多烯紫杉醇

Docetaxel多西他赛是一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。

Docetaxel Chemical Structure

Docetaxel Chemical Structure

CAS: 114977-28-5

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 746.97 现货
10mg RMB 563.39 现货
50mg RMB 2233.96 现货
250mg RMB 6036.03 现货
1g RMB 10401.3 现货
更大包装 有超大折扣

400-668-6834

info@selleck.cn

免费分装
免费预溶

客户使用Selleck的Docetaxel发表文献183

产品质控

批次: 纯度: 99.98%
99.96

Docetaxel相关产品

Microtubule Associated抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
NUGC-3 Growth Inhibition Assay IC50=0.00308 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.00308 μM SANGER
U031 Growth Inhibition Assay IC50=0.00307 μM SANGER
HEC-1 Growth Inhibition Assay IC50=0.00303 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.00302 μM SANGER
DEL Growth Inhibition Assay IC50=0.00301 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.003 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.00298 μM SANGER
GP5d Growth Inhibition Assay IC50=0.00296 μM SANGER
SW1088 Growth Inhibition Assay IC50=0.00295 μM SANGER
DOK Growth Inhibition Assay IC50=0.00294 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=0.00293 μM SANGER
SW962 Growth Inhibition Assay IC50=0.00293 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=0.00286 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=0.00286 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.00285 μM SANGER
HT-3 Growth Inhibition Assay IC50=0.00282 μM SANGER
JEG-3 Growth Inhibition Assay IC50=0.00282 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=0.00281 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.00281 μM SANGER
HT-29 Growth Inhibition Assay IC50=0.0028 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=0.00278 μM SANGER
ES3 Growth Inhibition Assay IC50=0.00277 μM SANGER
HCC70 Growth Inhibition Assay IC50=0.00277 μM SANGER
SW1417 Growth Inhibition Assay IC50=0.00276 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=0.00274 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=0.00272 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.00271 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.00266 μM SANGER
A388 Growth Inhibition Assay IC50=0.00265 μM SANGER
SNU-387 Growth Inhibition Assay IC50=0.00261 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=0.0026 μM SANGER
OC-314 Growth Inhibition Assay IC50=0.00256 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.00254 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.00252 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=0.00251 μM SANGER
U251 Growth Inhibition Assay IC50=0.0025 μM SANGER
KGN Growth Inhibition Assay IC50=0.00247 μM SANGER
HCE-4 Growth Inhibition Assay IC50=0.00247 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=0.00246 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=0.00243 μM SANGER
A673 Growth Inhibition Assay IC50=0.00235 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.00235 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=0.00234 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.00233 μM SANGER
JVM-3 Growth Inhibition Assay IC50=0.00233 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.00232 μM SANGER
GOTO Growth Inhibition Assay IC50=0.00227 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.00226 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=0.00225 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=0.00225 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=0.00225 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.00222 μM SANGER
COR-L23 Growth Inhibition Assay IC50=0.0022 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=0.00217 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=0.00216 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.00216 μM SANGER
SW756 Growth Inhibition Assay IC50=0.00216 μM SANGER
BHY Growth Inhibition Assay IC50=0.00216 μM SANGER
EFM-19 Growth Inhibition Assay IC50=0.00215 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=0.00212 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=0.00212 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.00209 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=0.00203 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.00199 μM SANGER
M059J Growth Inhibition Assay IC50=0.00198 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.00197 μM SANGER
H4 Growth Inhibition Assay IC50=0.00196 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.00194 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.00192 μM SANGER
NCI-H1048 Growth Inhibition Assay IC50=0.00192 μM SANGER
M14 Growth Inhibition Assay IC50=0.00191 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.00189 μM SANGER
NB17 Growth Inhibition Assay IC50=0.00189 μM SANGER
SBC-5 Growth Inhibition Assay IC50=0.00187 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=0.00184 μM SANGER
647-V Growth Inhibition Assay IC50=0.00184 μM SANGER
Becker Growth Inhibition Assay IC50=0.00183 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.00182 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.00181 μM SANGER
AU565 Growth Inhibition Assay IC50=0.00181 μM SANGER
HCT-116 Growth Inhibition Assay IC50=0.00181 μM SANGER
GCT Growth Inhibition Assay IC50=0.0018 μM SANGER
DB Growth Inhibition Assay IC50=0.00178 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.00176 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=0.00176 μM SANGER
U-2-OS Growth Inhibition Assay IC50=0.00175 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.00174 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=0.00173 μM SANGER
D-247MG Growth Inhibition Assay IC50=0.00173 μM SANGER
697 Growth Inhibition Assay IC50=0.00172 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.0017 μM SANGER
ME-180 Growth Inhibition Assay IC50=0.00169 μM SANGER
SW13 Growth Inhibition Assay IC50=0.00169 μM SANGER
D-336MG Growth Inhibition Assay IC50=0.00169 μM SANGER
EW-11 Growth Inhibition Assay IC50=0.00169 μM SANGER
Saos-2 Growth Inhibition Assay IC50=0.00168 μM SANGER
CAL-39 Growth Inhibition Assay IC50=0.00163 μM SANGER
A172 Growth Inhibition Assay IC50=0.00163 μM SANGER
MCF7 Growth Inhibition Assay IC50=0.00161 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=0.00157 μM SANGER
KP-4 Growth Inhibition Assay IC50=0.00156 μM SANGER
ES4 Growth Inhibition Assay IC50=0.00155 μM SANGER
23132-87 Growth Inhibition Assay IC50=0.00155 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=0.00154 μM SANGER
MG-63 Growth Inhibition Assay IC50=0.00151 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.00148 μM SANGER
A427 Growth Inhibition Assay IC50=0.00148 μM SANGER
TI-73 Growth Inhibition Assay IC50=0.00144 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.00144 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=0.00144 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=0.00143 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.00141 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.00135 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=0.00135 μM SANGER
SAS Growth Inhibition Assay IC50=0.00134 μM SANGER
SCC-9 Growth Inhibition Assay IC50=0.00132 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=0.00131 μM SANGER
D-423MG Growth Inhibition Assay IC50=0.0013 μM SANGER
SW982 Growth Inhibition Assay IC50=0.00127 μM SANGER
G-401 Growth Inhibition Assay IC50=0.00127 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=0.00124 μM SANGER
H9 Growth Inhibition Assay IC50=0.00124 μM SANGER
SF268 Growth Inhibition Assay IC50=0.00121 μM SANGER
A375 Growth Inhibition Assay IC50=0.00121 μM SANGER
LK-2 Growth Inhibition Assay IC50=0.00121 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.00119 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=0.00118 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.00118 μM SANGER
T98G Growth Inhibition Assay IC50=0.00117 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.00117 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.00116 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=0.00113 μM SANGER
KNS-62 Growth Inhibition Assay IC50=0.00112 μM SANGER
EPLC-272H Growth Inhibition Assay IC50=0.00111 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=0.0011 μM SANGER
NBsusSR Growth Inhibition Assay IC50=0.0011 μM SANGER
NB13 Growth Inhibition Assay IC50=0.00107 μM SANGER
TE-5 Growth Inhibition Assay IC50=0.00106 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.00105 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=0.00105 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.00104 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.00104 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.00102 μM SANGER
BPH-1 Growth Inhibition Assay IC50=0.00102 μM SANGER
SW48 Growth Inhibition Assay IC50=0.00101 μM SANGER
RKO Growth Inhibition Assay IC50=0.000989 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.000958 μM SANGER
BCPAP Growth Inhibition Assay IC50=0.000947 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.000947 μM SANGER
GMS-10 Growth Inhibition Assay IC50=0.000941 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.000933 μM SANGER
ES5 Growth Inhibition Assay IC50=0.00091 μM SANGER
Detroit562 Growth Inhibition Assay IC50=0.000902 μM SANGER
A549 Growth Inhibition Assay IC50=0.000882 μM SANGER
8505C Growth Inhibition Assay IC50=0.000854 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=0.00084 μM SANGER
SW954 Growth Inhibition Assay IC50=0.000823 μM SANGER
YH-13 Growth Inhibition Assay IC50=0.000791 μM SANGER
HOS Growth Inhibition Assay IC50=0.000782 μM SANGER
K5 Growth Inhibition Assay IC50=0.000778 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.000773 μM SANGER
ES1 Growth Inhibition Assay IC50=0.00077 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.000758 μM SANGER
HN Growth Inhibition Assay IC50=0.000758 μM SANGER
HSC-2 Growth Inhibition Assay IC50=0.000755 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=0.000745 μM SANGER
EW-3 Growth Inhibition Assay IC50=0.000745 μM SANGER
SCC-4 Growth Inhibition Assay IC50=0.000739 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.00073 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=0.000728 μM SANGER
YKG-1 Growth Inhibition Assay IC50=0.000707 μM SANGER
G-402 Growth Inhibition Assay IC50=0.000706 μM SANGER
Daoy Growth Inhibition Assay IC50=0.0007 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=0.0007 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.000687 μM SANGER
SCC-25 Growth Inhibition Assay IC50=0.00068 μM SANGER
TE-9 Growth Inhibition Assay IC50=0.000676 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.000674 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=0.000657 μM SANGER
639-V Growth Inhibition Assay IC50=0.000647 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.000615 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=0.000592 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.000589 μM SANGER
SW780 Growth Inhibition Assay IC50=0.000587 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.000581 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=0.00058 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.000569 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.000561 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.000558 μM SANGER
A2058 Growth Inhibition Assay IC50=0.000544 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.000542 μM SANGER
GI-1 Growth Inhibition Assay IC50=0.000528 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.000517 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.000501 μM SANGER
FTC-133 Growth Inhibition Assay IC50=0.000489 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.000479 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.000471 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.000466 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.000448 μM SANGER
SBC-1 Growth Inhibition Assay IC50=0.00043 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.000423 μM SANGER
GAMG Growth Inhibition Assay IC50=0.000416 μM SANGER
ES7 Growth Inhibition Assay IC50=0.000389 μM SANGER
COLO-800 Growth Inhibition Assay IC50=0.000388 μM SANGER
RH-1 Growth Inhibition Assay IC50=0.000386 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.000375 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.000366 μM SANGER
CAL-27 Growth Inhibition Assay IC50=0.000339 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=0.000336 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=0.000302 μM SANGER
SF539 Growth Inhibition Assay IC50=0.000302 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=0.000281 μM SANGER
A498 Growth Inhibition Assay IC50=0.000278 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.000268 μM SANGER
ES8 Growth Inhibition Assay IC50=0.00026 μM SANGER
NB14 Growth Inhibition Assay IC50=0.00026 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=0.000255 μM SANGER
HSC-4 Growth Inhibition Assay IC50=0.000239 μM SANGER
GT3TKB Growth Inhibition Assay IC50=0.000232 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.000185 μM SANGER
D-566MG Growth Inhibition Assay IC50=0.000182 μM SANGER
ESS-1 Growth Inhibition Assay IC50=0.000179 μM SANGER
HCE-T Growth Inhibition Assay IC50=0.000162 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.000159 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.000157 μM SANGER
5637 Growth Inhibition Assay IC50=0.000143 μM SANGER
HSC-3 Growth Inhibition Assay IC50=0.000132 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.00312 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.00314 μM SANGER
22RV1 Growth Inhibition Assay IC50=0.00315 μM SANGER
MKN28 Growth Inhibition Assay IC50=0.00317 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.00322 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.00322 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.00324 μM SANGER
CaR-1 Growth Inhibition Assay IC50=0.00327 μM SANGER
AGS Growth Inhibition Assay IC50=0.00328 μM SANGER
SF126 Growth Inhibition Assay IC50=0.00329 μM SANGER
UACC-62 Growth Inhibition Assay IC50=0.0033 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.00334 μM SANGER
A2780 Growth Inhibition Assay IC50=0.00335 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.00337 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.0034 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=0.00342 μM SANGER
HuO9 Growth Inhibition Assay IC50=0.00346 μM SANGER
U-266 Growth Inhibition Assay IC50=0.00348 μM SANGER
MLMA Growth Inhibition Assay IC50=0.00355 μM SANGER
U-87-MG Growth Inhibition Assay IC50=0.00355 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.00358 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.00359 μM SANGER
EGI-1 Growth Inhibition Assay IC50=0.00362 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=0.00364 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=0.00368 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=0.00372 μM SANGER
L-363 Growth Inhibition Assay IC50=0.00376 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.00376 μM SANGER
BT-20 Growth Inhibition Assay IC50=0.00376 μM SANGER
SNB75 Growth Inhibition Assay IC50=0.00381 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.0039 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.00393 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=0.00396 μM SANGER
SW620 Growth Inhibition Assay IC50=0.00397 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=0.00399 μM SANGER
RD Growth Inhibition Assay IC50=0.004 μM SANGER
HLE Growth Inhibition Assay IC50=0.00405 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=0.00407 μM SANGER
KM12 Growth Inhibition Assay IC50=0.00408 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.00408 μM SANGER
D-502MG Growth Inhibition Assay IC50=0.0041 μM SANGER
KNS-42 Growth Inhibition Assay IC50=0.00412 μM SANGER
LS-123 Growth Inhibition Assay IC50=0.00425 μM SANGER
SiHa Growth Inhibition Assay IC50=0.0043 μM SANGER
T47D Growth Inhibition Assay IC50=0.00431 μM SANGER
EW-24 Growth Inhibition Assay IC50=0.00433 μM SANGER
CAL-120 Growth Inhibition Assay IC50=0.00435 μM SANGER
JAR Growth Inhibition Assay IC50=0.00437 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.00438 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.00438 μM SANGER
Calu-6 Growth Inhibition Assay IC50=0.00447 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=0.00451 μM SANGER
MKN45 Growth Inhibition Assay IC50=0.00453 μM SANGER
ECC10 Growth Inhibition Assay IC50=0.0046 μM SANGER
RVH-421 Growth Inhibition Assay IC50=0.00461 μM SANGER
TGBC11TKB Growth Inhibition Assay IC50=0.00469 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.00471 μM SANGER
LN-405 Growth Inhibition Assay IC50=0.00482 μM SANGER
S-117 Growth Inhibition Assay IC50=0.00486 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.00497 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=0.00499 μM SANGER
NCI-H1666 Growth Inhibition Assay IC50=0.00505 μM SANGER
Mewo Growth Inhibition Assay IC50=0.00505 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.00507 μM SANGER
COLO-680N Growth Inhibition Assay IC50=0.00508 μM SANGER
FADU Growth Inhibition Assay IC50=0.0051 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.00511 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=0.00511 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=0.00513 μM SANGER
BV-173 Growth Inhibition Assay IC50=0.0053 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=0.00531 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.00531 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=0.00535 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=0.00535 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=0.0054 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=0.00545 μM SANGER
SN12C Growth Inhibition Assay IC50=0.0055 μM SANGER
KY821 Growth Inhibition Assay IC50=0.00551 μM SANGER
SW1573 Growth Inhibition Assay IC50=0.00554 μM SANGER
OE19 Growth Inhibition Assay IC50=0.00559 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.00567 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=0.00568 μM SANGER
SW1783 Growth Inhibition Assay IC50=0.0057 μM SANGER
8305C Growth Inhibition Assay IC50=0.00576 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.00586 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=0.00586 μM SANGER
COLO-824 Growth Inhibition Assay IC50=0.0059 μM SANGER
HCC38 Growth Inhibition Assay IC50=0.006 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.00601 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=0.00607 μM SANGER
MFM-223 Growth Inhibition Assay IC50=0.00616 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=0.00622 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.00623 μM SANGER
D-283MED Growth Inhibition Assay IC50=0.00624 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=0.00624 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=0.00624 μM SANGER
SW626 Growth Inhibition Assay IC50=0.00624 μM SANGER
WM-115 Growth Inhibition Assay IC50=0.00627 μM SANGER
NB69 Growth Inhibition Assay IC50=0.00629 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.0063 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=0.00639 μM SANGER
IGR-1 Growth Inhibition Assay IC50=0.00641 μM SANGER
ACN Growth Inhibition Assay IC50=0.00644 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.00652 μM SANGER
HC-1 Growth Inhibition Assay IC50=0.00656 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.00658 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.00679 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=0.00679 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=0.00683 μM SANGER
SCC-15 Growth Inhibition Assay IC50=0.00689 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=0.00693 μM SANGER
DMS-114 Growth Inhibition Assay IC50=0.00696 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=0.007 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=0.00725 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.00725 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=0.00727 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.0073 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=0.0073 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=0.00732 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=0.00748 μM SANGER
SW900 Growth Inhibition Assay IC50=0.00755 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=0.00758 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=0.00773 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=0.00781 μM SANGER
786-0 Growth Inhibition Assay IC50=0.00786 μM SANGER
no-10 Growth Inhibition Assay IC50=0.00788 μM SANGER
SCH Growth Inhibition Assay IC50=0.00818 μM SANGER
COLO-741 Growth Inhibition Assay IC50=0.0082 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=0.00822 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.00827 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=0.0084 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=0.00856 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=0.00857 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.00857 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.0086 μM SANGER
DK-MG Growth Inhibition Assay IC50=0.0086 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.0088 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.00906 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=0.0091 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=0.00917 μM SANGER
HPAF-II Growth Inhibition Assay IC50=0.00926 μM SANGER
A204 Growth Inhibition Assay IC50=0.00934 μM SANGER
TK10 Growth Inhibition Assay IC50=0.00977 μM SANGER
BHT-101 Growth Inhibition Assay IC50=0.0098 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=0.00983 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=0.00988 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=0.01005 μM SANGER
AM-38 Growth Inhibition Assay IC50=0.01024 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.01029 μM SANGER
TCCSUP Growth Inhibition Assay IC50=0.01036 μM SANGER
SW1990 Growth Inhibition Assay IC50=0.01047 μM SANGER
HCC1395 Growth Inhibition Assay IC50=0.01056 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=0.01056 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=0.01073 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=0.01077 μM SANGER
HT-1197 Growth Inhibition Assay IC50=0.01084 μM SANGER
MOLT-13 Growth Inhibition Assay IC50=0.01086 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=0.01087 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=0.01093 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=0.01094 μM SANGER
EFO-21 Growth Inhibition Assay IC50=0.011 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.01102 μM SANGER
DU-145 Growth Inhibition Assay IC50=0.01107 μM SANGER
SF295 Growth Inhibition Assay IC50=0.01126 μM SANGER
ABC-1 Growth Inhibition Assay IC50=0.01146 μM SANGER
TE-6 Growth Inhibition Assay IC50=0.01148 μM SANGER
GAK Growth Inhibition Assay IC50=0.01158 μM SANGER
LU-139 Growth Inhibition Assay IC50=0.01166 μM SANGER
EW-18 Growth Inhibition Assay IC50=0.01169 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=0.01173 μM SANGER
KU812 Growth Inhibition Assay IC50=0.01198 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=0.01198 μM SANGER
LU-99A Growth Inhibition Assay IC50=0.012 μM SANGER
NB10 Growth Inhibition Assay IC50=0.01209 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=0.01229 μM SANGER
YAPC Growth Inhibition Assay IC50=0.01237 μM SANGER
HT55 Growth Inhibition Assay IC50=0.01242 μM SANGER
NB7 Growth Inhibition Assay IC50=0.01243 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=0.01254 μM SANGER
EW-22 Growth Inhibition Assay IC50=0.01256 μM SANGER
UMC-11 Growth Inhibition Assay IC50=0.01283 μM SANGER
MKN7 Growth Inhibition Assay IC50=0.01283 μM SANGER
OE33 Growth Inhibition Assay IC50=0.013 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.01324 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.01328 μM SANGER
IA-LM Growth Inhibition Assay IC50=0.0133 μM SANGER
HuH-7 Growth Inhibition Assay IC50=0.01354 μM SANGER
J82 Growth Inhibition Assay IC50=0.0139 μM SANGER
CFPAC-1 Growth Inhibition Assay IC50=0.01406 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.01429 μM SANGER
A704 Growth Inhibition Assay IC50=0.01438 μM SANGER
SW684 Growth Inhibition Assay IC50=0.01452 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.0146 μM SANGER
U-118-MG Growth Inhibition Assay IC50=0.0147 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=0.01477 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.01516 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.01523 μM SANGER
MS-1 Growth Inhibition Assay IC50=0.01545 μM SANGER
A101D Growth Inhibition Assay IC50=0.01549 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.016 μM SANGER
CAS-1 Growth Inhibition Assay IC50=0.01609 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=0.01636 μM SANGER
T-24 Growth Inhibition Assay IC50=0.01705 μM SANGER
MEG-01 Growth Inhibition Assay IC50=0.01737 μM SANGER
NCI-H2291 Growth Inhibition Assay IC50=0.01838 μM SANGER
SW872 Growth Inhibition Assay IC50=0.01867 μM SANGER
no-11 Growth Inhibition Assay IC50=0.01887 μM SANGER
NB5 Growth Inhibition Assay IC50=0.01891 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.01934 μM SANGER
BT-474 Growth Inhibition Assay IC50=0.01943 μM SANGER
OAW-28 Growth Inhibition Assay IC50=0.01956 μM SANGER
ES6 Growth Inhibition Assay IC50=0.02008 μM SANGER
PC-3 Growth Inhibition Assay IC50=0.02036 μM SANGER
COR-L88 Growth Inhibition Assay IC50=0.02054 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.02068 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=0.02161 μM SANGER
LoVo Growth Inhibition Assay IC50=0.02172 μM SANGER
HCC1954 Growth Inhibition Assay IC50=0.02192 μM SANGER
COLO-792 Growth Inhibition Assay IC50=0.02196 μM SANGER
KLE Growth Inhibition Assay IC50=0.02323 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=0.02349 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=0.02465 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=0.02474 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=0.02477 μM SANGER
GCIY Growth Inhibition Assay IC50=0.02502 μM SANGER
MKN1 Growth Inhibition Assay IC50=0.02576 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=0.02654 μM SANGER
RMG-I Growth Inhibition Assay IC50=0.027 μM SANGER
NB12 Growth Inhibition Assay IC50=0.0272 μM SANGER
RCM-1 Growth Inhibition Assay IC50=0.02819 μM SANGER
C3A Growth Inhibition Assay IC50=0.02822 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.02837 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.02837 μM SANGER
EW-13 Growth Inhibition Assay IC50=0.02904 μM SANGER
CAL-72 Growth Inhibition Assay IC50=0.02918 μM SANGER
HH Growth Inhibition Assay IC50=0.02998 μM SANGER
UACC-257 Growth Inhibition Assay IC50=0.0303 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.0303 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=0.03052 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.03063 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.03169 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.03185 μM SANGER
SW1463 Growth Inhibition Assay IC50=0.03337 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.03421 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=0.03633 μM SANGER
ACHN Growth Inhibition Assay IC50=0.0371 μM SANGER
RH-18 Growth Inhibition Assay IC50=0.03763 μM SANGER
HCC2218 Growth Inhibition Assay IC50=0.0379 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.03869 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=0.03876 μM SANGER
COLO-668 Growth Inhibition Assay IC50=0.03887 μM SANGER
LU-65 Growth Inhibition Assay IC50=0.03904 μM SANGER
NB6 Growth Inhibition Assay IC50=0.03952 μM SANGER
HT Growth Inhibition Assay IC50=0.04007 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.04095 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=0.04305 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.04335 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=0.04417 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=0.04469 μM SANGER
DMS-79 Growth Inhibition Assay IC50=0.04579 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=0.04614 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=0.04849 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.0501 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.05067 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=0.05093 μM SANGER
HT-1376 Growth Inhibition Assay IC50=0.05186 μM SANGER
EKVX Growth Inhibition Assay IC50=0.05384 μM SANGER
Capan-2 Growth Inhibition Assay IC50=0.05396 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=0.05446 μM SANGER
UACC-893 Growth Inhibition Assay IC50=0.05462 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=0.05788 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=0.058 μM SANGER
SW948 Growth Inhibition Assay IC50=0.05996 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.06167 μM SANGER
NH-12 Growth Inhibition Assay IC50=0.06244 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=0.06361 μM SANGER
A431 Growth Inhibition Assay IC50=0.06374 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=0.06383 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=0.06582 μM SANGER
BALL-1 Growth Inhibition Assay IC50=0.06674 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=0.07073 μM SANGER
LS-1034 Growth Inhibition Assay IC50=0.07369 μM SANGER
MFE-280 Growth Inhibition Assay IC50=0.07536 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.07676 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.07787 μM SANGER
CW-2 Growth Inhibition Assay IC50=0.07832 μM SANGER
SW837 Growth Inhibition Assay IC50=0.08342 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.08501 μM SANGER
HCC1419 Growth Inhibition Assay IC50=0.08987 μM SANGER
HMV-II Growth Inhibition Assay IC50=0.0901 μM SANGER
BEN Growth Inhibition Assay IC50=0.09385 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=0.09556 μM SANGER
JVM-2 Growth Inhibition Assay IC50=0.09716 μM SANGER
CAL-54 Growth Inhibition Assay IC50=0.1004 μM SANGER
T84 Growth Inhibition Assay IC50=0.10952 μM SANGER
SHP-77 Growth Inhibition Assay IC50=0.11641 μM SANGER
G-361 Growth Inhibition Assay IC50=0.12324 μM SANGER
Calu-3 Growth Inhibition Assay IC50=0.13816 μM SANGER
HCC1937 Growth Inhibition Assay IC50=0.14937 μM SANGER
KM-H2 Growth Inhibition Assay IC50=0.1501 μM SANGER
769-P Growth Inhibition Assay IC50=0.15843 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=0.16061 μM SANGER
D-542MG Growth Inhibition Assay IC50=0.16278 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.17441 μM SANGER
NCI-H2029 Growth Inhibition Assay IC50=0.20243 μM SANGER
ZR-75-30 Growth Inhibition Assay IC50=0.20643 μM SANGER
SW1116 Growth Inhibition Assay IC50=0.21117 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.27614 μM SANGER
LU-135 Growth Inhibition Assay IC50=0.27739 μM SANGER
MC116 Growth Inhibition Assay IC50=0.28309 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.28773 μM SANGER
NCI-H630 Growth Inhibition Assay IC50=0.29376 μM SANGER
L-428 Growth Inhibition Assay IC50=0.29883 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=0.31291 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=0.31784 μM SANGER
HEL Growth Inhibition Assay IC50=0.3224 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=0.32298 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.33477 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.33755 μM SANGER
Mo-T Growth Inhibition Assay IC50=0.33853 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=0.339 μM SANGER
HCC1569 Growth Inhibition Assay IC50=0.34309 μM SANGER
COLO-678 Growth Inhibition Assay IC50=0.37002 μM SANGER
COR-L105 Growth Inhibition Assay IC50=0.3793 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=0.38382 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=0.43976 μM SANGER
C8166 Growth Inhibition Assay IC50=0.49023 μM SANGER
COLO-679 Growth Inhibition Assay IC50=0.62172 μM SANGER
TE-12 Growth Inhibition Assay IC50=0.65394 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.6622 μM SANGER
H-EMC-SS Growth Inhibition Assay IC50=0.70546 μM SANGER
SNU-449 Growth Inhibition Assay IC50=0.72748 μM SANGER
C32 Growth Inhibition Assay IC50=0.74112 μM SANGER
K-562 Growth Inhibition Assay IC50=0.77024 μM SANGER
DJM-1 Growth Inhibition Assay IC50=0.78781 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=0.79183 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=0.907 μM SANGER
NY Growth Inhibition Assay IC50=0.93352 μM SANGER
NCI-H1993 Growth Inhibition Assay IC50=1.19289 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=1.22089 μM SANGER
点击查看更多细胞系数据

生物活性

产品描述 Docetaxel多西他赛是一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。
靶点
Microtubules [1]
(Cell-free assay)
体外研究(In Vitro)
体外研究活性 Docetaxel是一种细胞毒性剂,尤其对于增殖细胞,Docetaxel促进微管蛋白束的形成,还能诱导持续的有丝分裂阻滞,随后分裂阻滞的细胞凋亡或永久抑制分裂。 Docetaxel抑制微管的动态不稳定性及踏车现象,导致染色体不能分开到子细胞中,这样又会反过来触发有丝分裂过早结束,而不是在细胞周期的特定时期进行抑制作用。[2] Docetaxel (150 ng/mL) 处理人类小细胞肺癌 N417细胞系 1小时,抑制50% 细胞生长。 Docetaxel 处理 KB 人类表皮癌细胞, T24 人类膀胱癌细胞, Calc18 人类乳腺癌细胞, 和HCT116人类结肠腺癌96-120小时,IC50值分别为8 ng/mL, 4 ng/mL, 5 ng/mL, 和 7 ng/mL。[3] Docetaxel 处理人类癌细胞Hs746T (胃), AGS (胃), HeLa (子宫颈), CaSki (子宫颈), BxPC3 (胰腺), Capan-1 (胰腺) 24小时,抑制克隆存活,IC50 分别为 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM, 0.3 nM。[4] 通过克隆形成实验测评Docetaxel处理人类 卵巢癌细胞系 OVCA432, A2780, A2780/cp8 12天期间,IC50值分别达到0.06 nM, 0.6 nM, 和3 nM。[5]Docetaxel 作用于9种培养的人类胃癌细胞系 (MKN-7, -28, -45, NUGC-4 和KATO-III, ST-SA-1, NAKAJIMA 和ST-KM, KKLS)时,IC50 分别为 >1.2 μM, 0.6 nM, 0.1 nM, 3.5 nM, 4 nM, 99 nM, 0.3 nM,0.5 nM, 0.9 nM。[6]在体外,Docetaxel在极低浓度时,抑制内皮细胞迁移,这并不影响微管的大体形态或抑制细胞增殖,对微管动力学产生更微妙的影响。Docetaxel 抑制 HUVEC 迁移,IC50 为1 pM。Docetaxel 抑制血管生成因子胸甘磷酸化酶或血管内皮生长因子刺激的HUVEC趋化性,IC 50 为10 pM 。[7] Docetaxel (30 μM) 在添加10%人血清的培养基中温育12小时,诱导人单核细胞。[8]
细胞实验 细胞系 人类胃癌细胞系 MKN-28
浓度 6 nM
孵育时间 3 天
方法 180 μL培养基中的2000个细胞接种到96孔板中,20 μL 药物溶液同时按一式三份加到每孔中。实验板在37°C下含5% CO2的培养箱中温育3天。在第3天,每孔加入25 μL MTT 试剂。温育4小时后,除去培养基。每孔加入0.2 mL DMSO,使用机械式搅拌机充分混合,溶解形成的MTT-甲臜晶体。在540 nm (OD)处测定吸光值。
实验图片 检测方法 检测指标 实验图片 PMID
Western blot PIM1 cyclin B pSTAT3 / STAT3 p-p53 / p53 18426800
Immunofluorescence α-tubulin cleaved PARP / cleaved caspase-3 Acetylated tubulin SQSTM1 / LAMP1 27177833
Growth inhibition assay Cell viability 22996738
体内研究(In Vivo)
体内研究活性 Docetaxel (33 mg/kg/dose, 静脉注射,每四天注射3次) 处理M2OL2 结肠移植瘤,结果肿瘤生长延迟19.3。Docetaxel作用于MX-1, SK-MEL-2, LX-1 和 OVCAR-3 移植瘤,也具有很强的抗肿瘤活性。Docetaxel抑制成纤维细胞生长因子2的血管反应,IC50为5.4 mg/kg,Docetaxel按10 mg/kg剂量处理小鼠,在14天期间,每周注射两次,结果血管完全堵塞。Docetaxel对内皮细胞迁移和/或微血管形成具有选择性,因为炎症细胞浸润到基底膜对Docetaxel抑制不太敏感。[7]
动物实验 Animal Models 携带人类结肠癌移植瘤CX-1的小鼠
Dosages 33 mg/kg
Administration 静脉注射,每四天注射3次
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05156372 Not yet recruiting
Prostate Cancer Metastatic|Castrate Resistant Prostate Cancer|Metastatic Prostate Cancer|Metastatic Prostate Adenocarcinoma
The University of Texas Health Science Center at San Antonio
December 2023 Not Applicable
NCT05863325 Recruiting
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
CSPC ZhongQi Pharmaceutical Technology Co. Ltd.
June 27 2023 Phase 2
NCT05858398 Not yet recruiting
Breast Cancer
Centre Henri Becquerel|Erasmus Medical Center|Universitaire Ziekenhuizen KU Leuven
May 30 2023 Not Applicable

化学信息&溶解度

分子量 807.88 分子式

C43H53NO14

CAS号 114977-28-5 SDF Download Docetaxel SDF
Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 100 mg/mL ( 123.78 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Ethanol : 100 mg/mL

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

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