Docetaxel (RP56976)

For research use only. Not for use in humans.

目录号：S1148 别名： NSC 628503 中文名称：多西他赛，多烯紫杉醇

CAS No. 114977-28-5

Docetaxel (RP56976, NSC 628503)多西他赛一种taxol类似物，是一种microtubules解聚抑制剂，通过结合于稳定的微管发挥作用。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 746.97	现货
10mg	RMB 563.39	现货
50mg	RMB 2233.96	现货
100mg	RMB 4013.1	现货
250mg	RMB 6036.03	现货
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客户使用Selleck生产的Docetaxel (RP56976)发表文献129篇：

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Cell, 2018, 174(5):1200-1215

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Nat Commun, 2021, 12(1):1812

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Biomaterials, 2021, 272:120770

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J Pathol, 2021, 10.1002/path.5652

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Cancers (Basel), 2021, 13(16)4168

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Cancers (Basel), 2021, 13(11)2539

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Mater Sci Eng C Mater Biol Appl, 2021, 124:112039

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Eur J Med Chem, 2021, 211:113003

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J Cell Mol Med, 2021, 10.1111/jcmm.16684

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J Cell Mol Med, 2021, 10.1111/jcmm.16155

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Int J Mol Sci, 2021, 22(8)4098

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Invest New Drugs, 2021, 10.1007/s10637-020-01003-3

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Prostate, 2021, 10.1002/pros.24138

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Chem Biol Interact, 2021, 340:109448

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Molecules, 2021, 26(15)4549

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Clin Res Hepatol Gastroenterol, 2021, 45(5):101586

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Hum Cell, 2021, 10.1007/s13577-021-00579-z

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Mol Med Rep, 2021, 23(1)40

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Adv Biol Regul, 2021, S2212-4926(20)30091-9

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Adv Sci (Weinh), 2020, 7(21):2001018

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Nat Commun, 2020, 10;11(1):2935

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J Immunother Cancer, 2020, 8(2)e000807

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Oncogene, 2020, 10.1038/s41388-020-1168-9

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Cancers (Basel), 2020, 12(12)E3784

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Cancers (Basel), 2020, 12(12)E3869

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Br J Cancer, 2020, 10.1038/s41416-020-01091-1

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Cells, 2020, 9(1)

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Cells, 2020, 9(6):E1474

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Mol Cancer Ther, 2020, 19(1):39-51

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Mol Cancer Ther, 2020, 19(2):364-374

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Am J Cancer Res, 2020, 10(12):4251-4265

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Am J Cancer Res, 2020, 10(8):2649-2676

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Am J Cancer Res, 2020, 10(1):249-262

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Am J Cancer Res, 2020, 10(10):3302-3315

PubMed: 33163271 ( click the link to review the publication )

Oncogenesis, 2020, 7;9(5):45

PubMed: 32382014 ( click the link to review the publication )

Front Oncol, 2020, 1.4125

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Front Oncol, 2020, 10:524922

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Int J Mol Sci, 2020, 21(23)E9034

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Int J Biol Sci, 2020, 16(7):1121-1134

PubMed: 32174789 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

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Exp Cell Res, 2020, 10.1016/j.yexcr.2020.111981

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Toxicol In Vitro, 2020, 104928

PubMed: 32622998 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2020, 10.1007/s00280-020-04187-w

PubMed: 33169187 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )
Pharmaceutics, 2020, 30;12(5) pii: E413

PubMed: 32366029 ( click the link to review the publication )

Sci Rep, 2020, 10(1):13124

PubMed: 32753665 ( click the link to review the publication )

Cell Death Dis, 2020, 11(7):577

PubMed: 32709853 ( click the link to review the publication )

Cancer Lett, 2020, 470:95-105

PubMed: 31644929 ( click the link to review the publication )

Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-0206

PubMed: 31113844 ( click the link to review the publication )

Cell Syst, 2019, 8(2):97-108

PubMed: 30797775 ( click the link to review the publication )

Theranostics, 2019, 9(19):5464-5477

PubMed: 31534497 ( click the link to review the publication )

Cancer Res, 2019, canres.0656.2019

PubMed: 31694904 ( click the link to review the publication )

Cell Rep, 2019, 28(9):2317-2330

PubMed: 31461649 ( click the link to review the publication )

Cell Rep, 2019, 28(13):3367-3380

PubMed: 31553907 ( click the link to review the publication )

Cell Death Differ, 2019, 10.1038/s41418-019-0473-8

PubMed: 31857702 ( click the link to review the publication )

Int J Cancer, 2019, 145(7):1970-1981

PubMed: 30807643 ( click the link to review the publication )

Cancers (Basel), 2019, 11(4)

PubMed: 31018595 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)E1945

PubMed: 31817360 ( click the link to review the publication )

Cell Death Discov, 2019, 0.30486111111

PubMed: 31583122 ( click the link to review the publication )

Cell Death Dis, 2019, 10(9):660

PubMed: 31506430 ( click the link to review the publication )

Arch Toxicol, 2019, 93(4):953-964

PubMed: 30863990 ( click the link to review the publication )

Cells, 2019, 9(1)

PubMed: 31877673 ( click the link to review the publication )

Mol Cancer Res, 2019, 17(10):2115-2125

PubMed: 31266816 ( click the link to review the publication )

J Virol, 2019, 93(4)

PubMed: 30487274 ( click the link to review the publication )

Sci Rep, 2019, 9(1):17380

PubMed: 31758030 ( click the link to review the publication )

Sci Rep, 2019, 9(1):19384

PubMed: 31852908 ( click the link to review the publication )

Sci Rep, 2019, 9(1):16647

PubMed: 31719636 ( click the link to review the publication )

Mol Cell Endocrinol, 2019, 498:110585

PubMed: 31536779 ( click the link to review the publication )
Clin Exp Metastasis, 2019, 36(2):97-108

PubMed: 30810874 ( click the link to review the publication )

Prostate, 2019, 79(11):1304-1315

PubMed: 31212367 ( click the link to review the publication )

Prostate, 2019, 79(9):1018-1031

PubMed: 31018021 ( click the link to review the publication )

J Cancer Res Clin Oncol, 2019, 145(3):551-559

PubMed: 30474758 ( click the link to review the publication )

Cancer Med, 2019, 10.1002/cam4.2764

PubMed: 31823522 ( click the link to review the publication )

Onco Targets Ther, 2019, 12:9899-9913

PubMed: 31819487 ( click the link to review the publication )

J Org Chem, 2019, 10.1021/acs.joc.9b02414

PubMed: 31858795 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(24):6421-6432

PubMed: 30087142 ( click the link to review the publication )

Cell Death Dis, 2018,

PubMed: 29752436 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(9):2024-2033

PubMed: 29959202 ( click the link to review the publication )

Sci Rep, 2018, 8(1):14672

PubMed: 30279484 ( click the link to review the publication )

J Biol Chem, 2018, 293(33):12719-12729

PubMed: 29934310 ( click the link to review the publication )

Cancer Manag Res, 2018, 10:6695-6703

PubMed: 30584364 ( click the link to review the publication )

Biomed Pharmacother, 2018, 99:445-450

PubMed: 29665645 ( click the link to review the publication )

Transl Oncol, 2018, 11(6):1406-1418

PubMed: 30219696 ( click the link to review the publication )

Oncol Rep, 2018, 39(4):1901-1909

PubMed: 29393407 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2018, 81(2):255-267

PubMed: 29189915 ( click the link to review the publication )

Gene, 2018, 658:152-158

PubMed: 29518547 ( click the link to review the publication )

Int Urol Nephrol, 2018, 50(4):675-686

PubMed: 29460131 ( click the link to review the publication )

Ann Surg Treat Res, 2018, 95(5):240-248

PubMed: 30402442 ( click the link to review the publication )

Oncotarget, 2018, 9(42):26884-26899

PubMed: 29928491 ( click the link to review the publication )

Nan Fang Yi Ke Da Xue Xue Bao, 2018, 38(6):723-730

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Oncotarget, 2018, 9(56):30773-30786

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Oncotarget, 2018,

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Proc Natl Acad Sci U S A, 2017, 114(18):E3729-E3738

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Cancer Res, 2017, 77(12):3268-3279

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Oncogene, 2017, 36(14):1991-2001

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Oncogene, 2017, 36(11):1573-1584

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Mol Cancer Ther, 2017, 16(11):2552-2562

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Mol Cancer Ther, 2017, 77(22):6282-6298

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Mol Cancer Res, 2017, 15(6):660-669

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J Pharmacol Exp Ther, 2017, 363(1):20-34

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Breast Cancer Res Treat, 2017, 165(3):531-543

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Oncol Lett, 2017, 14(4):4349-4354

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Oncotarget, 2017, 8(67):111225-111245

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Oncotarget, 2017, 9(9):8206-8222

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Prostate Cancer Prostatic Dis, 2016, 19(4):349-357

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Int J Cancer, 2015, 136(9):2065-77

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Breast Cancer Res, 2015, 17:59

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PLoS ONE, 2015,

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Oncotarget, 2015, 6(29):27923-37

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Oncogenesis, 2014, 3(10):e124

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Oncogenesis, 2014, 3:e100

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产品安全说明书

Microtubule Associated抑制剂选择性比较

生物活性

产品描述

Docetaxel (RP56976, NSC 628503)多西他赛一种taxol类似物，是一种microtubules解聚抑制剂，通过结合于稳定的微管发挥作用。

靶点

Microtubules ^[1]
(Cell-free assay)

体外研究

Docetaxel是一种细胞毒性剂，尤其对于增殖细胞，Docetaxel促进微管蛋白束的形成，还能诱导持续的有丝分裂阻滞，随后分裂阻滞的细胞凋亡或永久抑制分裂。 Docetaxel抑制微管的动态不稳定性及踏车现象，导致染色体不能分开到子细胞中，这样又会反过来触发有丝分裂过早结束，而不是在细胞周期的特定时期进行抑制作用。^[2] Docetaxel (150 ng/mL) 处理人类小细胞肺癌 N417细胞系 1小时，抑制50% 细胞生长。 Docetaxel 处理 KB 人类表皮癌细胞, T24 人类膀胱癌细胞, Calc18 人类乳腺癌细胞, 和HCT116人类结肠腺癌96-120小时，IC50值分别为8 ng/mL, 4 ng/mL, 5 ng/mL, 和 7 ng/mL。^[3] Docetaxel 处理人类癌细胞Hs746T (胃), AGS (胃), HeLa (子宫颈), CaSki (子宫颈), BxPC3 (胰腺), Capan-1 (胰腺) 24小时，抑制克隆存活，IC50 分别为 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM, 0.3 nM。^[4] 通过克隆形成实验测评Docetaxel处理人类卵巢癌细胞系 OVCA432, A2780, A2780/cp8 12天期间，IC50值分别达到0.06 nM, 0.6 nM, 和3 nM。^[5]Docetaxel 作用于9种培养的人类胃癌细胞系 (MKN-7, -28, -45, NUGC-4 和KATO-III, ST-SA-1, NAKAJIMA 和ST-KM, KKLS)时，IC50 分别为 >1.2 μM, 0.6 nM, 0.1 nM, 3.5 nM, 4 nM, 99 nM, 0.3 nM,0.5 nM, 0.9 nM。^[6]在体外，Docetaxel在极低浓度时，抑制内皮细胞迁移，这并不影响微管的大体形态或抑制细胞增殖，对微管动力学产生更微妙的影响。Docetaxel 抑制 HUVEC 迁移，IC50 为1 pM。Docetaxel 抑制血管生成因子胸甘磷酸化酶或血管内皮生长因子刺激的HUVEC趋化性，IC 50 为10 pM 。^[7] Docetaxel (30 μM) 在添加10％人血清的培养基中温育12小时，诱导人单核细胞。^[8]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
HSC-3	MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3fHVGlEPTB;MD6wNFAyOzJizszN	NEW4dmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
5637	M1TIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4\OZ2lEPTB;MD6wNFAyPDNizszN	M1;3TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
HT-144	NUnE[HFxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVzJR\|UxRTBwMECwNVU4KM7:TR?=	MoHsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
NCI-H292	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{XofGlEPTB;MD6wNFAyPTlizszN	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
HCE-T	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWn4cY1SUUN3ME2wMlAxODF4MjFOwG0>	MmXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
ESS-1	NETyN3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{i4T2lEPTB;MD6wNFAyPzlizszN	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
D-566MG	NIPBUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmCxTWM2OD1yLkCwNFE5OiEQvF2=	NGLON4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
CAL-62	Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4rwVmlEPTB;MD6wNFAyQDVizszN	M2T2OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
GT3TKB	M2C3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWfobFdNUUN3ME2wMlAxODJ\|MjFOwG0>	NXXTcYt6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
HSC-4	NUmwcXRMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2rzdmlEPTB;MD6wNFAzOzlizszN	M1W3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
KOSC-2	NGjtWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnr6TWM2OD1yLkCwNFI2PSEQvF2=	NFzTWJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
NB14	NYjPTmp5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYK5V\|BnUUN3ME2wMlAxODJ4IN88US=>	MnnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
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NCI-H1838	NYj0XoRXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIr3dmxKSzVyPUCuN\|E4QDRizszN	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
HEL	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlrLTWM2OD1yLkOyNlQh\|ryP	NULic5lORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
OCI-AML2	M4PVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4jFemlEPTB;MD6zNlI6QCEQvF2=	NH7NT5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
A3-KAW	NF;NbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE\WPWxKSzVyPUCuN\|M1PzdizszN	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
IGROV-1	M4TCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFTYTZNKSzVyPUCuN\|M4PTVizszN	M1v4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
Mo-T	NFzZSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2jPUWlEPTB;MD6zN\|g2OyEQvF2=	M2rpNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
HDLM-2	MnPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHjwPJJKSzVyPUCuN\|M6KM7:TR?=	NVrBR4hDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
HCC1569	MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlGwTWM2OD1yLkO0N\|A6KM7:TR?=	MkPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
COLO-678	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYnBcYVxUUN3ME2wMlM4ODB{IN88US=>	MlvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
COR-L105	MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH7TdIJKSzVyPUCuN\|c6OyEQvF2=	M1fUSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
SK-MEL-24	NVi4V4J7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MljXTWM2OD1yLkO4N\|gzKM7:TR?=	M3vnS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
COLO-320-HSR	MonmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTBwNEO5O\|Yh\|ryP	M3zxR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
C8166	NFTHdlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1K2OGlEPTB;MD60PVAzOyEQvF2=	M4P0TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
COLO-679	NUK2U2V3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWDwcW9sUUN3ME2wMlYzOTd{IN88US=>	Mn\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
TE-12	MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1;R[mlEPTB;MD62OVM6PCEQvF2=	NIDZfGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
HAL-01	M{DSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUj3b2pQUUN3ME2wMlY3OjJizszN	Ml32QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
H-EMC-SS	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1L2ZWlEPTB;MD63NFU1PiEQvF2=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
SNU-449	M3S0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlrOTWM2OD1yLkeyO\|Q5KM7:TR?=	M1u3R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
C32	NVTCdZZwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2CzdWlEPTB;MD63OFEyOiEQvF2=	MmDrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
K-562	NV3PdmFHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnXRTWM2OD1yLke3NFI1KM7:TR?=	M3jWeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
DJM-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\VdWFKSzVyPUCuO\|g4QDFizszN	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
RCC10RGB	Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTPTWM2OD1yLke5NVg{KM7:TR?=	MlPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
CAL-85-1	NXruO3BtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHTSd41KSzVyPUCuPVA4KM7:TR?=	MnXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
NY	NFvnUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn3rTWM2OD1yLkmzN\|UzKM7:TR?=	NX7LfGs2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
NCI-H1993	NX\mdZlsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnHwTWM2OD1zLkG5Nlg6KM7:TR?=	NG[2e5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
SK-OV-3	M1\2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPGcItKSzVyPUGuNlIxQDlizszN	NFHET2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	PIM1; PubMed: 18426800 J Biol Chem Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ cyclin B; PubMed: 18426800 J Biol Chem Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points. pSTAT3 / STAT3 ; PubMed: 18426800 J Biol Chem Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time. p-p53 / p53; PubMed: 22996738 Prostate C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.	18426800 22996738
Immunofluorescence	α-tubulin; PubMed: 27177833 Exp Cell Res Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ𢡄뾤Ղ䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemｾ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒ｾ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wｾ᎒䨼Ą鹿齃殺獸W戀醙 cleaved PARP / cleaved caspase-3; PubMed: 21087597 Biochem Pharmacol Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à Acetylated tubulin ; PubMed: 18426800 J Biol Chem Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm. SQSTM1 / LAMP1; PubMed: 29795139 Cell Death Dis AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ	27177833 21087597 18426800 29795139
Growth inhibition assay	Cell viability ; PubMed: 22996738 Prostate Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr.	22996738

体内研究

Docetaxel (33 mg/kg/dose, 静脉注射，每四天注射3次) 处理M2OL2 结肠移植瘤，结果肿瘤生长延迟19.3。Docetaxel作用于MX-1, SK-MEL-2, LX-1 和 OVCAR-3 移植瘤，也具有很强的抗肿瘤活性。Docetaxel抑制成纤维细胞生长因子2的血管反应，IC50为5.4 mg/kg，Docetaxel按10 mg/kg剂量处理小鼠，在14天期间，每周注射两次，结果血管完全堵塞。Docetaxel对内皮细胞迁移和/或微血管形成具有选择性，因为炎症细胞浸润到基底膜对Docetaxel抑制不太敏感。^[7]

细胞实验：^[5]	- 合并 Cell lines: 人类胃癌细胞系 MKN-28 Concentrations: 6 nM Incubation Time: 3 天 Method: 180 μL培养基中的2000个细胞接种到96孔板中，20 μL 药物溶液同时按一式三份加到每孔中。实验板在37°C下含5% CO₂的培养箱中温育3天。在第3天,每孔加入25 μL MTT 试剂。温育4小时后，除去培养基。每孔加入0.2 mL DMSO，使用机械式搅拌机充分混合，溶解形成的MTT-甲臜晶体。在540 nm (OD)处测定吸光值。 (Only for Reference)
动物实验：^[6]	- 合并 Animal Models: 携带人类结肠癌移植瘤CX-1的小鼠 Dosages: 33 mg/kg Administration: 静脉注射，每四天注射3次 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	100 mg/mL (123.78 mM)
	Water	Insoluble
	Ethanol	'53 mg/mL warmed
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+30% PEG 300+5% Tween 80+ddH2O	2mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Docetaxel (RP56976) SDF

分子量	807.88
化学式	C₄₃H₅₃NO₁₄
CAS号	114977-28-5
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	NSC 628503

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05027204	Not yet recruiting	Drug: Docetaxel\|Drug: Nivolumab	Squamous Cell Carcinoma of Head and Neck	CSPC ZhongQi Pharmaceutical Technology Co. Ltd.	September 2021	Phase 1\|Phase 2
NCT04467801	Recruiting	Drug: Ipatasertib	NSCLC Stage IV\|NSCLC Stage IIIB	Jun Zhang MD PhD\|University of Iowa\|University of Kentucky\|University of Kansas Medical Center	August 18 2021	Phase 2
NCT04811118	Recruiting	Drug: Docetaxel for Injection (Albumin-bound)\|Drug: Taxotere	Advanced Solid Tumors	CSPC ZhongQi Pharmaceutical Technology Co. Ltd.	May 18 2021	Phase 1
NCT04823910	Not yet recruiting	--	Prostate Cancer	Physiomics\|Portsmouth Hospitals NHS Trust\|National Institute for Health Research United Kingdom	May 2021	--
NCT04889599	Recruiting	Drug: BH009 (Docetaxel injection)\|Drug: Docetaxel injection	Docetaxel\|Solid Tumours\|Bioequivalence	Zhuhai Beihai Biotech Co. Ltd	April 29 2021	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

研究领域

产品类型

定制您的化合物库

Docetaxel (RP56976)

客户使用Selleck生产的Docetaxel (RP56976)发表文献129篇：

产品安全说明书

Microtubule Associated抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Docetaxel (RP56976) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

Microtubule Associated Signaling Pathway Map

相关Microtubule Associated产品