Docetaxel

For research use only. Not for use in humans.

目录号:S1148 别名: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 746.97 现货
RMB 563.39 现货
RMB 2233.96 现货
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客户使用Selleck生产的Docetaxel发表文献56篇:

产品安全说明书

Microtubule Associated抑制剂选择性比较

生物活性

产品描述 Docetaxel多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。
靶点
Microtubules [1]
(Cell-free assay)
体外研究

Docetaxel是一种细胞毒性剂,尤其对于增殖细胞,Docetaxel促进微管蛋白束的形成,还能诱导持续的有丝分裂阻滞,随后分裂阻滞的细胞凋亡或永久抑制分裂。 Docetaxel抑制微管的动态不稳定性及踏车现象,导致染色体不能分开到子细胞中,这样又会反过来触发有丝分裂过早结束,而不是在细胞周期的特定时期进行抑制作用。[2] Docetaxel (150 ng/mL) 处理人类小细胞肺癌 N417细胞系 1小时,抑制50% 细胞生长。 Docetaxel 处理 KB 人类表皮癌细胞, T24 人类膀胱癌细胞, Calc18 人类乳腺癌细胞, 和HCT116人类结肠腺癌96-120小时,IC50值分别为8 ng/mL, 4 ng/mL, 5 ng/mL, 和 7 ng/mL。[3] Docetaxel 处理人类癌细胞Hs746T (胃), AGS (胃), HeLa (子宫颈), CaSki (子宫颈), BxPC3 (胰腺), Capan-1 (胰腺) 24小时,抑制克隆存活,IC50 分别为 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM, 0.3 nM。[4] 通过克隆形成实验测评Docetaxel处理人类 卵巢癌细胞系 OVCA432, A2780, A2780/cp8 12天期间,IC50值分别达到0.06 nM, 0.6 nM, 和3 nM。[5]Docetaxel 作用于9种培养的人类胃癌细胞系 (MKN-7, -28, -45, NUGC-4 和KATO-III, ST-SA-1, NAKAJIMA 和ST-KM, KKLS)时,IC50 分别为 >1.2 μM, 0.6 nM, 0.1 nM, 3.5 nM, 4 nM, 99 nM, 0.3 nM,0.5 nM, 0.9 nM。[6]在体外,Docetaxel在极低浓度时,抑制内皮细胞迁移,这并不影响微管的大体形态或抑制细胞增殖,对微管动力学产生更微妙的影响。Docetaxel 抑制 HUVEC 迁移,IC50 为1 pM。Docetaxel 抑制血管生成因子胸甘磷酸化酶或血管内皮生长因子刺激的HUVEC趋化性,IC 50 为10 pM 。[7] Docetaxel (30 μM) 在添加10%人血清的培养基中温育12小时,诱导人单核细胞。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 M{jpRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMECwNVMzKM7:TR?= NUDmfGRzW0GQR1XS
5637 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnPOZJ3UUN3ME2wMlAxODF2MzFOwG0> MmDpV2FPT0WU
HT-144 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\PVGlEPTB;MD6wNFAyPTdizszN NHewfmhUSU6JRWK=
NCI-H292 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\wc21xUUN3ME2wMlAxODF3OTFOwG0> NX;6OZQzW0GQR1XS
HCE-T NWHwNXRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPVUZBKSzVyPUCuNFAxOTZ{IN88US=> NE\tbYJUSU6JRWK=
ESS-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HsUGlEPTB;MD6wNFAyPzlizszN MkXtV2FPT0WU
D-566MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjoTWM2OD1yLkCwNFE5OiEQvF2= NYTDV|VoW0GQR1XS
CAL-62 NVW5eG1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMECwNVg2KM7:TR?= NWDCOWNOW0GQR1XS
GT3TKB NWXqeHJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[4NpdDUUN3ME2wMlAxODJ|MjFOwG0> M3fSZ3NCVkeHUh?=
HSC-4 M4TKeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;BNGY6UUN3ME2wMlAxODJ|OTFOwG0> MYLTRW5ITVJ?
KOSC-2 M{j6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknCTWM2OD1yLkCwNFI2PSEQvF2= NV3Cb21vW0GQR1XS
NB14 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;3WnhKSzVyPUCuNFAxOjZizszN M3XFc3NCVkeHUh?=
ES8 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITqUGNKSzVyPUCuNFAxOjZizszN NF7nT2pUSU6JRWK=
BFTC-905 NYP6OIpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMECwNlY5KM7:TR?= MmGzV2FPT0WU
A498 M1;N[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL0NlNKSzVyPUCuNFAxOjd6IN88US=> M1X0RXNCVkeHUh?=
HO-1-N-1 MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMECwNlgyKM7:TR?= MXTTRW5ITVJ?
SF539 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHXRllKSzVyPUCuNFAxOzB{IN88US=> NFfDc4JUSU6JRWK=
HuO-3N1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMECwN|AzKM7:TR?= MkTaV2FPT0WU
NCI-H510A MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLwTWM2OD1yLkCwNFM{PiEQvF2= MVHTRW5ITVJ?
CAL-27 MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P4[2lEPTB;MD6wNFA{OzlizszN MlvZV2FPT0WU
TE-8 M2nWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPYVnhYUUN3ME2wMlAxODN4NjFOwG0> NVK5T|VFW0GQR1XS
VA-ES-BJ Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\hZoI4UUN3ME2wMlAxODN5NTFOwG0> NHLaUJhUSU6JRWK=
RH-1 MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMECwN|g3KM7:TR?= NWnPSnd{W0GQR1XS
COLO-800 MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPJe3V3UUN3ME2wMlAxODN6ODFOwG0> NGDlbW5USU6JRWK=
ES7 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjTfmZKSzVyPUCuNFAxOzh7IN88US=> M1yzZXNCVkeHUh?=
GAMG NETF[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrDWFZ3UUN3ME2wMlAxODRzNjFOwG0> M4iyR3NCVkeHUh?=
Ca9-22 M1H3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojiTWM2OD1yLkCwNFQzOyEQvF2= NET5bo1USU6JRWK=
SBC-1 MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fSZWlEPTB;MD6wNFA1OyEQvF2= NHLwZ4JUSU6JRWK=
RPMI-7951 NIP6RWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq2d|J3UUN3ME2wMlAxODR2ODFOwG0> MnfIV2FPT0WU
SW1710 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;HN5JLUUN3ME2wMlAxODR4NjFOwG0> NIjMZ|dUSU6JRWK=
HGC-27 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnUTWM2OD1yLkCwNFQ4OSEQvF2= MVLTRW5ITVJ?
MC-IXC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMECwOFc6KM7:TR?= MnjKV2FPT0WU
FTC-133 NYfWOZJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TwcWlEPTB;MD6wNFA1QDlizszN NITsdoVUSU6JRWK=
HT-1080 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXKTWM2OD1yLkCwNFUxOSEQvF2= Ml;TV2FPT0WU
NMC-G1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fGTWlEPTB;MD6wNFA2OTdizszN NV;HRW14W0GQR1XS
GI-1 M13meGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMECwOVI5KM7:TR?= M3rmfXNCVkeHUh?=
CGTH-W-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMECwOVQzKM7:TR?= NXL4ZWdTW0GQR1XS
A2058 M4L2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTG[JBKSzVyPUCuNFAxPTR2IN88US=> NHXiZoxUSU6JRWK=
ETK-1 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLTTWM2OD1yLkCwNFU2QCEQvF2= M{i4TnNCVkeHUh?=
NEC8 NFzjOI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXm0eGJRUUN3ME2wMlAxODV4MTFOwG0> Mn3sV2FPT0WU
TE-11 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTUZmZuUUN3ME2wMlAxODV4OTFOwG0> NEK1b2RUSU6JRWK=
NCI-H720 M4DmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMECwOVgh|ryP MlK1V2FPT0WU
PSN1 NVLLUphiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf0d3JvUUN3ME2wMlAxODV6MTFOwG0> M1Hw[nNCVkeHUh?=
SW780 NEPi[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7RTWM2OD1yLkCwNFU5PyEQvF2= M{X4W3NCVkeHUh?=
8-MG-BA NIPhZ4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnFcoRRUUN3ME2wMlAxODV6OTFOwG0> MkC5V2FPT0WU
EC-GI-10 M1Tzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvKUXBKSzVyPUCuNFAxPTl{IN88US=> NI[2V4lUSU6JRWK=
SJSA-1 NIHXcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljrTWM2OD1yLkCwNFYyPSEQvF2= NWf0eoliW0GQR1XS
639-V MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMECwOlQ4KM7:TR?= M4rSSHNCVkeHUh?=
PFSK-1 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT2W3lKSzVyPUCuNFAxPjV5IN88US=> NEjZWZlUSU6JRWK=
DMS-273 NFvu[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMECwOlc1KM7:TR?= NH25NGRUSU6JRWK=
TE-9 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjXSJRKSzVyPUCuNFAxPjd4IN88US=> M3ridHNCVkeHUh?=
SCC-25 M2DhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMECwOlgh|ryP MYrTRW5ITVJ?
PA-1 NWXiOll3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rkNmlEPTB;MD6wNFA3QDdizszN MlPGV2FPT0WU
MHH-ES-1 Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfucHdKSzVyPUCuNFAxPyEQvF2= M1TNOXNCVkeHUh?=
Daoy MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\YTWM2OD1yLkCwNFch|ryP MkD1V2FPT0WU
G-402 M{GyeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPVPZRTUUN3ME2wMlAxODdyNjFOwG0> M1e0VHNCVkeHUh?=
YKG-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vWRmlEPTB;MD6wNFA4ODdizszN NFHzbYpUSU6JRWK=
Ca-Ski NF7hN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2GyRWlEPTB;MD6wNFA4OjhizszN M2XzeXNCVkeHUh?=
CHP-212 NYrGXoJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHCN|RKSzVyPUCuNFAxPzNizszN NFX4clZUSU6JRWK=
SCC-4 NX\UZ2p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17qNmlEPTB;MD6wNFA4OzlizszN NXPxZ5ZkW0GQR1XS
EW-3 NFXydGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLGTWM2OD1yLkCwNFc1PSEQvF2= Mm\oV2FPT0WU
P12-ICHIKAWA NHrwO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjwTWM2OD1yLkCwNFc1PSEQvF2= M4XSRnNCVkeHUh?=
HSC-2 NEj0OJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrzUZhKSzVyPUCuNFAxPzV3IN88US=> NES4cmhUSU6JRWK=
HN NUHSd|JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMECwO|U5KM7:TR?= Ml\rV2FPT0WU
LXF-289 NE\IV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMECwO|U5KM7:TR?= NFLhXYtUSU6JRWK=
ES1 NYK0bXhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq2W4I5UUN3ME2wMlAxODd5IN88US=> MY\TRW5ITVJ?
NTERA-S-cl-D1 NH;DSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3BTWM2OD1yLkCwNFc4OyEQvF2= MmnPV2FPT0WU
K5 NYL4O3gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ON2lEPTB;MD6wNFA4PzhizszN NVX1SI9wW0GQR1XS
HOS MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{W1[GlEPTB;MD6wNFA4QDJizszN NVmwOY5IW0GQR1XS
YH-13 MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjPTWM2OD1yLkCwNFc6OSEQvF2= MYLTRW5ITVJ?
SW954 M4\XO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnBTYVKSzVyPUCuNFAxQDJ|IN88US=> MWnTRW5ITVJ?
KYSE-510 Mnr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULLUI5rUUN3ME2wMlAxODh2IN88US=> NV60VlE6W0GQR1XS
8505C M3K4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMECwPFU1KM7:TR?= M3vte3NCVkeHUh?=
A549 M3fQNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\qWnpKSzVyPUCuNFAxQDh{IN88US=> MX3TRW5ITVJ?
Detroit562 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXITWM2OD1yLkCwNFkxOiEQvF2= NVLze2R6W0GQR1XS
ES5 MnLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\QbmlEPTB;MD6wNFA6OSEQvF2= MkHLV2FPT0WU
KYSE-140 M{i3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMECwPVM{KM7:TR?= MnnXV2FPT0WU
GMS-10 NHPacZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XHNmlEPTB;MD6wNFA6PDFizszN NFHIbYxUSU6JRWK=
D-263MG NXnJSnJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXYb4xKSzVyPUCuNFAxQTR5IN88US=> Ml\wV2FPT0WU
BCPAP MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMECwPVQ4KM7:TR?= M4XkbHNCVkeHUh?=
CHL-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37neWlEPTB;MD6wNFA6PThizszN M1rNe3NCVkeHUh?=
RKO M1zMWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr4VHJMUUN3ME2wMlAxODl6OTFOwG0> M2fvfXNCVkeHUh?=
SW48 NUXkOJVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\FTWM2OD1yLkCwNVAyKM7:TR?= MV\TRW5ITVJ?
BPH-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzjTWM2OD1yLkCwNVAzKM7:TR?= NFzZRVBUSU6JRWK=
EFO-27 MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMECxNFIh|ryP Mlv5V2FPT0WU
CAL-33 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK1c3NWUUN3ME2wMlAxOTB2IN88US=> M{[wSXNCVkeHUh?=
NCI-H1792 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP1SIdmUUN3ME2wMlAxOTB2IN88US=> MW\TRW5ITVJ?
BB30-HNC MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjFdpdlUUN3ME2wMlAxOTB3IN88US=> MWLTRW5ITVJ?
VM-CUB-1 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMECxNFUh|ryP M{DVZXNCVkeHUh?=
TE-5 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMECxNFYh|ryP MmXoV2FPT0WU
NB13 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXTTWM2OD1yLkCwNVA4KM7:TR?= NUTGU4tnW0GQR1XS
NBsusSR NX61Z204T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH0UIVKSzVyPUCuNFAyOSEQvF2= NH:zW3JUSU6JRWK=
LNCaP-Clone-FGC M3vTbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMECxNUDPxE1? MnOzV2FPT0WU
EPLC-272H MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMECxNVEh|ryP NIrZVmxUSU6JRWK=
KNS-62 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;o[WpbUUN3ME2wMlAxOTF{IN88US=> NXjmTFF{W0GQR1XS
RERF-LC-MS NWrlOmNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnDPW9RUUN3ME2wMlAxOTF|IN88US=> NHTVdpZUSU6JRWK=
LOXIMVI NILwfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\4RmlEPTB;MD6wNFEyPiEQvF2= M{[5N3NCVkeHUh?=
KINGS-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMECxNVch|ryP Ml[yV2FPT0WU
T98G NYTKVXlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzyeJRJUUN3ME2wMlAxOTF5IN88US=> MV3TRW5ITVJ?
HCC1806 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TnNGlEPTB;MD6wNFEyQCEQvF2= M2fo[3NCVkeHUh?=
MZ1-PC M{fnbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfTWGlKSzVyPUCuNFAyOThizszN M2izcXNCVkeHUh?=
RT-112 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMECxNVkh|ryP MknhV2FPT0WU
LK-2 NYHLWFZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMECxNlEh|ryP MVPTRW5ITVJ?
A375 NHvOdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq5ZXVKSzVyPUCuNFAyOjFizszN MVvTRW5ITVJ?
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U031 MnfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\Ic2hRUUN3ME2wMlAxOzB5IN88US=> NUnpNmd{W0GQR1XS
BB65-RCC M1uwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMECzNFgh|ryP NUC3WoxbW0GQR1XS
NUGC-3 NITMTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnuNFZKSzVyPUCuNFA{ODhizszN NHr5SGpUSU6JRWK=
IST-SL1 NV[2Sll1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3yNZlrUUN3ME2wMlAxOzF{IN88US=> NYXXSIhsW0GQR1XS
LS-411N M2Hx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPSTWM2OD1yLkCwN|E1KM7:TR?= MVTTRW5ITVJ?
22RV1 MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMECzNVUh|ryP NIPxTFhUSU6JRWK=
MKN28 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrZcWhKSzVyPUCuNFA{OTdizszN NX20bmsyW0GQR1XS
ONS-76 M1G5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHaVpIxUUN3ME2wMlAxOzJ{IN88US=> MkTWV2FPT0WU
SH-4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jW[WlEPTB;MD6wNFMzOiEQvF2= NYP3e5VIW0GQR1XS
MIA-PaCa-2 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv4TWM2OD1yLkCwN|I1KM7:TR?= MXvTRW5ITVJ?
CaR-1 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe1SpBKSzVyPUCuNFA{OjdizszN Ml;JV2FPT0WU
AGS NVjqWI9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMECzNlgh|ryP MUPTRW5ITVJ?
SF126 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrwTWM2OD1yLkCwN|I6KM7:TR?= MVLTRW5ITVJ?
UACC-62 NXP5Uo1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7NVHZuUUN3ME2wMlAxOzNizszN NYDPNnA{W0GQR1XS
NCI-H28 NInX[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\3RZUxUUN3ME2wMlAxOzN2IN88US=> MmDlV2FPT0WU
A2780 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMECzN|Uh|ryP NVHRPIFqW0GQR1XS
CTV-1 M4TFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMECzN|ch|ryP MXTTRW5ITVJ?
LC-2-ad M1G2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMECzOEDPxE1? Ml31V2FPT0WU
NCI-H1770 M2PYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i4VGlEPTB;MD6wNFM1OiEQvF2= MVzTRW5ITVJ?
HuO9 NITu[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;ZeVNKSzVyPUCuNFA{PDZizszN MnzMV2FPT0WU
U-266 MmP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M370WWlEPTB;MD6wNFM1QCEQvF2= NEPyeYpUSU6JRWK=
MLMA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXux[o85UUN3ME2wMlAxOzV3IN88US=> M3HtWXNCVkeHUh?=
U-87-MG NXvYeHlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi1TWM2OD1yLkCwN|U2KM7:TR?= M1TiNXNCVkeHUh?=
GI-ME-N NIO2fZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rtRWlEPTB;MD6wNFM2QCEQvF2= MUnTRW5ITVJ?
HL-60 MnnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMECzOVkh|ryP MnT5V2FPT0WU
EGI-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TMbGlEPTB;MD6wNFM3OiEQvF2= NFW4d|JUSU6JRWK=
NCI-H23 NGjld5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;MNodKSzVyPUCuNFA{PjRizszN MX;TRW5ITVJ?
NCI-H226 Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnRZ4l6UUN3ME2wMlAxOzZ6IN88US=> NGPG[nRUSU6JRWK=
NCI-H520 M2GxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrETWM2OD1yLkCwN|czKM7:TR?= MWXTRW5ITVJ?
L-363 Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTG[ZdoUUN3ME2wMlAxOzd4IN88US=> Mlq3V2FPT0WU
CAL-12T NV34dVNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LVZWlEPTB;MD6wNFM4PiEQvF2= Mnf1V2FPT0WU
BT-20 M{TwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP2TWM2OD1yLkCwN|c3KM7:TR?= MmP0V2FPT0WU
SNB75 MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMECzPFEh|ryP M3vTdXNCVkeHUh?=
A4-Fuk MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMECzPUDPxE1? NE\xe5hUSU6JRWK=
BE-13 NXTlZ3hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMECzPVMh|ryP NX7E[2NDW0GQR1XS
NCI-H1395 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP6ZY1KSzVyPUCuNFA{QTZizszN M1PCcHNCVkeHUh?=
SW620 NYiwemdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMECzPVch|ryP M2HuT3NCVkeHUh?=
KNS-81-FD NY\6Zo1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjjTWM2OD1yLkCwN|k6KM7:TR?= NVTKXHN[W0GQR1XS
RD NXvvd|d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEC0JO69VQ>? NYnMbnhKW0GQR1XS
HLE Mmi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEC0NFUh|ryP NYDPcY9uW0GQR1XS
OVCAR-3 NVX4SJZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX6S29YUUN3ME2wMlAxPDB5IN88US=> NYnxNXpoW0GQR1XS
KM12 M4i3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfDTWM2OD1yLkCwOFA5KM7:TR?= NVvnPIpPW0GQR1XS
HCC2998 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDGTWM2OD1yLkCwOFA5KM7:TR?= NILmb|VUSU6JRWK=
D-502MG MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jVR2lEPTB;MD6wNFQyKM7:TR?= NVHqXoU6W0GQR1XS
KNS-42 NE[5N5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\IOGlEPTB;MD6wNFQyOiEQvF2= M3W0fXNCVkeHUh?=
LS-123 NHz0dIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DnXWlEPTB;MD6wNFQzPSEQvF2= M2fHeXNCVkeHUh?=
SiHa M4TM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPLcGh1UUN3ME2wMlAxPDNizszN MUHTRW5ITVJ?
T47D NWLLVG8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofJTWM2OD1yLkCwOFMyKM7:TR?= M4HwfnNCVkeHUh?=
EW-24 M2LaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXJR|hKSzVyPUCuNFA1OzNizszN Mn21V2FPT0WU
CAL-120 NViweWdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M336eWlEPTB;MD6wNFQ{PSEQvF2= NYDPbnFiW0GQR1XS
JAR M1;KNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEC0N|ch|ryP NXTCfXp[W0GQR1XS
QIMR-WIL NEDOS41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;lTmhKSzVyPUCuNFA1OzhizszN MVzTRW5ITVJ?
OCUB-M NES5SGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\G[mFKSzVyPUCuNFA1OzhizszN NH3mdJNUSU6JRWK=
Calu-6 NEjC[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fMcmlEPTB;MD6wNFQ1PyEQvF2= M4XIRXNCVkeHUh?=
MDA-MB-453 NULLOXU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEC0OVEh|ryP NEfqOI9USU6JRWK=
MKN45 M1nUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXFTWdKSzVyPUCuNFA1PTNizszN MWrTRW5ITVJ?
ECC10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TVUmlEPTB;MD6wNFQ3KM7:TR?= MVHTRW5ITVJ?
RVH-421 MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHudo1lUUN3ME2wMlAxPDZzIN88US=> MXfTRW5ITVJ?
TGBC11TKB Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m2PGlEPTB;MD6wNFQ3QSEQvF2= MUjTRW5ITVJ?
MOLT-4 M{LlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TBc2lEPTB;MD6wNFQ4OSEQvF2= NWfDT49XW0GQR1XS
LN-405 MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEC0PFIh|ryP MV3TRW5ITVJ?
S-117 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\TVYJlUUN3ME2wMlAxPDh4IN88US=> MkG5V2FPT0WU
RPMI-8226 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEC0PVch|ryP NYnJVmRJW0GQR1XS
KYSE-150 M1\3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEC0PVkh|ryP NEjjcY9USU6JRWK=
NCI-H1666 NH\w[|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXOTWM2OD1yLkCwOVA2KM7:TR?= NGf2cGJUSU6JRWK=
Mewo NEnmO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEC1NFUh|ryP MkC1V2FPT0WU
AN3-CA NHr6RoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPQZZdKSzVyPUCuNFA2ODdizszN MYPTRW5ITVJ?
COLO-680N M1vneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP3UmhKSzVyPUCuNFA2ODhizszN NVPHfVlpW0GQR1XS
FADU NUPqXWhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDSfHBKSzVyPUCuNFA2OSEQvF2= NYHtWFkyW0GQR1XS
GB-1 M1nsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X1U2lEPTB;MD6wNFUyOSEQvF2= MlLaV2FPT0WU
KASUMI-1 NFWybnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;wbWlEPTB;MD6wNFUyOSEQvF2= Mm\NV2FPT0WU
NOMO-1 NFfLTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHZV4lKSzVyPUCuNFA2OTNizszN MlG5V2FPT0WU
BV-173 NUG5OoxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjsTWM2OD1yLkCwOVMh|ryP NGW5[ZBUSU6JRWK=
RO82-W-1 NVTkTlUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\GT4RYUUN3ME2wMlAxPTNzIN88US=> MX\TRW5ITVJ?
LB2241-RCC Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\sU5dKSzVyPUCuNFA2OzFizszN Mmm5V2FPT0WU
NCI-H2170 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPqXnBvUUN3ME2wMlAxPTN3IN88US=> M4DUc3NCVkeHUh?=
SK-N-AS MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTrTWM2OD1yLkCwOVM2KM7:TR?= NU\hOoJEW0GQR1XS
NCI-H1651 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLGTWM2OD1yLkCwOVQh|ryP NYrQdplNW0GQR1XS
NCI-SNU-5 Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\mTWM2OD1yLkCwOVQ2KM7:TR?= NUjUOll4W0GQR1XS
SN12C M1zjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm3Z|FKSzVyPUCuNFA2PSEQvF2= NXnWSXQ2W0GQR1XS
KY821 NFvabGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXFVGFJUUN3ME2wMlAxPTVzIN88US=> MUDTRW5ITVJ?
SW1573 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC4dY9KSzVyPUCuNFA2PTRizszN MXfTRW5ITVJ?
OE19 NV7MUnB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDUeXZSUUN3ME2wMlAxPTV7IN88US=> Mn73V2FPT0WU
MPP-89 NHHseIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPQVlJRUUN3ME2wMlAxPTZ5IN88US=> M4i5c3NCVkeHUh?=
HuCCT1 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIS0VYtKSzVyPUCuNFA2PjhizszN M{jYSXNCVkeHUh?=
SW1783 NWnJN2pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X5NmlEPTB;MD6wNFU4KM7:TR?= NYO3OolwW0GQR1XS
8305C MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XvcGlEPTB;MD6wNFU4PiEQvF2= NELoPJZUSU6JRWK=
OVCAR-4 NIjs[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTKUnpKSzVyPUCuNFA2QDZizszN Mo\EV2FPT0WU
MMAC-SF MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fjOGlEPTB;MD6wNFU5PiEQvF2= Mn;mV2FPT0WU
COLO-824 NES4S|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXwTI5KSzVyPUCuNFA2QSEQvF2= NVjTZmVRW0GQR1XS
HCC38 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfYRXdKSzVyPUCuNFA3KM7:TR?= NF:wXnRUSU6JRWK=
NCI-H1648 M3XuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnmTWM2OD1yLkCwOlAyKM7:TR?= M3PRfnNCVkeHUh?=
NCI-H1573 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH0eVAzUUN3ME2wMlAxPjB5IN88US=> MkfsV2FPT0WU
MFM-223 NFPvd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;QdmVoUUN3ME2wMlAxPjF4IN88US=> M{W0c3NCVkeHUh?=
NCI-H810 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXkTWM2OD1yLkCwOlIzKM7:TR?= MnTLV2FPT0WU
EM-2 NGPVXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEC2NlMh|ryP M1XuO3NCVkeHUh?=
D-283MED NUDhfXFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3CVnR{UUN3ME2wMlAxPjJ2IN88US=> MnvpV2FPT0WU
NCI-H1755 MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\vUXlNUUN3ME2wMlAxPjJ2IN88US=> NULvPGVJW0GQR1XS
KYSE-70 NVvlWllET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rBRWlEPTB;MD6wNFYzPCEQvF2= MkDvV2FPT0WU
SW626 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\icVluUUN3ME2wMlAxPjJ2IN88US=> MmLZV2FPT0WU
WM-115 NYfHXW9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe0[XVKSzVyPUCuNFA3OjdizszN MULTRW5ITVJ?
NB69 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PKUmlEPTB;MD6wNFYzQSEQvF2= M1TIfnNCVkeHUh?=
DOHH-2 NHjieJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzkNW01UUN3ME2wMlAxPjNizszN NYjkfZNwW0GQR1XS
MEL-JUSO M1uzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojMTWM2OD1yLkCwOlM6KM7:TR?= MXHTRW5ITVJ?
IGR-1 M4qye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLwPYRMUUN3ME2wMlAxPjRzIN88US=> NIKwUI5USU6JRWK=
ACN M{TH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LSdGlEPTB;MD6wNFY1PCEQvF2= MUjTRW5ITVJ?
KARPAS-45 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEC2OVIh|ryP M{X5Z3NCVkeHUh?=
HC-1 NH\sWnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37od2lEPTB;MD6wNFY2PiEQvF2= NFzyOpFUSU6JRWK=
MZ2-MEL MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYewbVJRUUN3ME2wMlAxPjV6IN88US=> NEO3OZVUSU6JRWK=
NCI-H1355 M{jHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XQ[2lEPTB;MD6wNFY4QSEQvF2= NFnhSZpUSU6JRWK=
HuP-T4 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrIZnJRUUN3ME2wMlAxPjd7IN88US=> NFvHZppUSU6JRWK=
AsPC-1 NEL3dZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrLN3FNUUN3ME2wMlAxPjh|IN88US=> NGmy[YhUSU6JRWK=
SCC-15 NFfpUIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL6TWM2OD1yLkCwOlg6KM7:TR?= NULTWGdvW0GQR1XS
CP50-MEL-B M1nteWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LuVGlEPTB;MD6wNFY6OyEQvF2= M2fvTXNCVkeHUh?=
DMS-114 NV20dHp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1e2OGlEPTB;MD6wNFY6PiEQvF2= NXG1WlBoW0GQR1XS
KYSE-520 M4PFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Xv[2lEPTB;MD6wNFch|ryP NXfWfGdOW0GQR1XS
NCI-H2228 NXHZfG17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DwR2lEPTB;MD6wNFczPSEQvF2= NWfKSpRXW0GQR1XS
COLO-829 M1LHO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEC3NlUh|ryP MVXTRW5ITVJ?
NCI-H2052 NVr0Oo82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHztTG5KSzVyPUCuNFA4OjdizszN MWXTRW5ITVJ?
HOP-92 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC3PZlKSzVyPUCuNFA4OyEQvF2= MlWzV2FPT0WU
MDA-MB-231 MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEC3N{DPxE1? MWTTRW5ITVJ?
SK-MEL-30 Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzHdlhKSzVyPUCuNFA4OzJizszN NV3tOFNUW0GQR1XS
NCI-H2087 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETKS4JKSzVyPUCuNFA4PDhizszN M2fkcXNCVkeHUh?=
SW900 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2W0Z2lEPTB;MD6wNFc2PSEQvF2= NICzc4tUSU6JRWK=
NCI-H358 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jQS2lEPTB;MD6wNFc2QCEQvF2= MkS4V2FPT0WU
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NCI-H2342 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf2PI9QUUN3ME2wMlA{PjN|IN88US=> NVHzepo{W0GQR1XS
ACHN M2PjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLUdYxKSzVyPUCuNFM4OSEQvF2= MnjKV2FPT0WU
RH-18 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3MTWM2OD1yLkCzO|Y{KM7:TR?= M3r2VXNCVkeHUh?=
HCC2218 NFv2VYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEO3PUDPxE1? NGWzeY1USU6JRWK=
OS-RC-2 NHrmSWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH2O4U2UUN3ME2wMlA{QDZ7IN88US=> NHvJcnFUSU6JRWK=
KP-N-YN NWPZc|JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEO4O|Yh|ryP MmriV2FPT0WU
COLO-668 NU\iXIExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\lPIxKUUN3ME2wMlA{QDh5IN88US=> M3LoOnNCVkeHUh?=
LU-65 MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW1THhKSzVyPUCuNFM6ODRizszN NGD3OoRUSU6JRWK=
NB6 NX;X[5pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGeye2dKSzVyPUCuNFM6PTJizszN NVfocIdKW0GQR1XS
HT NXTvPFc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMESwNFch|ryP NGPhcG5USU6JRWK=
COLO-684 NVPVepZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMESwPVUh|ryP NUW2eHNKW0GQR1XS
NCI-H1693 M3XoXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2j3cmlEPTB;MD6wOFMxPSEQvF2= M1G2OXNCVkeHUh?=
LAN-6 NHi5eGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\3bY84UUN3ME2wMlA1OzN3IN88US=> MYTTRW5ITVJ?
MDA-MB-175-VII NY\t[ZJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli5TWM2OD1yLkC0OFE4KM7:TR?= NX;STlBOW0GQR1XS
KMOE-2 M3\wVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:0eGlEPTB;MD6wOFQ3QSEQvF2= MkfaV2FPT0WU
DMS-79 NHvkXGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMES1O|kh|ryP MljOV2FPT0WU
MHH-NB-11 NV3pWoF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfqO3F6UUN3ME2wMlA1PjF2IN88US=> NW\WZ3AyW0GQR1XS
NCI-H69 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMES4OFkh|ryP Mn;jV2FPT0WU
KE-37 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\lSmlEPTB;MD6wOVAyKM7:TR?= MlizV2FPT0WU
Ramos-2G6-4C10 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEWwOlch|ryP MmrhV2FPT0WU
NCI-H1793 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnPVGRlUUN3ME2wMlA2ODl|IN88US=> NUjoXpdQW0GQR1XS
HT-1376 NUG1dVJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSzVFFKSzVyPUCuNFUyQDZizszN MVPTRW5ITVJ?
EKVX MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f2cmlEPTB;MD6wOVM5PCEQvF2= NHGx[FZUSU6JRWK=
Capan-2 NF\3NIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;vTWM2OD1yLkC1N|k3KM7:TR?= M4mxV3NCVkeHUh?=
DoTc2-4510 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nnSmlEPTB;MD6wOVQ1PiEQvF2= MmnFV2FPT0WU
UACC-893 NVPTXWR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHQfYFPUUN3ME2wMlA2PDZ{IN88US=> NEnGOGRUSU6JRWK=
SK-MEL-3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLXRZhKSzVyPUCuNFU4QDhizszN MWnTRW5ITVJ?
SK-MEL-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fnU2lEPTB;MD6wOVgh|ryP MWjTRW5ITVJ?
SW948 M4PCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrzTWM2OD1yLkC1PVk3KM7:TR?= MnPjV2FPT0WU
P30-OHK NYjlPI9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LhdGlEPTB;MD6wOlE3PyEQvF2= NGXDV2JUSU6JRWK=
NH-12 MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfDZWZEUUN3ME2wMlA3OjR2IN88US=> NFLkXo1USU6JRWK=
KU-19-19 NUPIZlBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jpe2lEPTB;MD6wOlM3OSEQvF2= MXvTRW5ITVJ?
A431 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnKdFltUUN3ME2wMlA3Ozd2IN88US=> MoHTV2FPT0WU
NCI-H2405 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwME[zPFMh|ryP NVf2eo9XW0GQR1XS
KARPAS-299 M3O4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwME[1PFIh|ryP NIf4Z2FUSU6JRWK=
BALL-1 NYT6e2ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO0TWM2OD1yLkC2Olc1KM7:TR?= NXXCZoFTW0GQR1XS
KURAMOCHI NYLhfW5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEewO|Mh|ryP M4LKSHNCVkeHUh?=
LS-1034 NF2wTHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW5TWM2OD1yLkC3N|Y6KM7:TR?= NYDmWIc2W0GQR1XS
MFE-280 MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnOXXZKSzVyPUCuNFc2OzZizszN Ml\3V2FPT0WU
HOP-62 M4C5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPafpRKSzVyPUCuNFc3PzZizszN MlPQV2FPT0WU
KG-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEe3PFch|ryP Mo\jV2FPT0WU
CW-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnkPHVrUUN3ME2wMlA4QDN{IN88US=> MoPzV2FPT0WU
SW837 NGnldWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjIRZlKSzVyPUCuNFg{PDJizszN Mny2V2FPT0WU
MFH-ino MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHUR|VuUUN3ME2wMlA5PTBzIN88US=> M3:z[XNCVkeHUh?=
HCC1419 NFPp[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;mUXVKSzVyPUCuNFg6QDdizszN MlLBV2FPT0WU
HMV-II NVr0fIZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEniZ2RKSzVyPUCuNFkxOSEQvF2= NIjlVW5USU6JRWK=
BEN NETDSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Tj[WlEPTB;MD6wPVM5PSEQvF2= NHPZSmtUSU6JRWK=
SK-N-FI MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XybmlEPTB;MD6wPVU2PiEQvF2= MnvGV2FPT0WU
JVM-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M171XWlEPTB;MD6wPVcyPiEQvF2= NV3HfWdKW0GQR1XS
CAL-54 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn2O3NKSzVyPUCuNVAxPCEQvF2= MUHTRW5ITVJ?
T84 M3TSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TRVGlEPTB;MD6xNFk2OiEQvF2= NI\INHdUSU6JRWK=
SHP-77 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PIU2lEPTB;MD6xNVY1OSEQvF2= NV\TVZgzW0GQR1XS
G-361 NXnxVJNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMUKzNlQh|ryP NHvnXYVUSU6JRWK=
Calu-3 MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMUO4NVYh|ryP NGfrcZFUSU6JRWK=
HCC1937 NX[4d5RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XqfGlEPTB;MD6xOFk{PyEQvF2= MYXTRW5ITVJ?
KM-H2 MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMUWwNUDPxE1? M3\YbnNCVkeHUh?=
769-P NFTJSZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD6TWM2OD1yLkG1PFQ{KM7:TR?= M3nj[XNCVkeHUh?=
NCI-H1304 NV63PWl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTESXFvUUN3ME2wMlE3ODZzIN88US=> MkDvV2FPT0WU
D-542MG NWrsSGxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ryVmlEPTB;MD6xOlI4QCEQvF2= M4nxcXNCVkeHUh?=
ATN-1 NG\pU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrYdmw2UUN3ME2wMlE4PDRzIN88US=> NHTCNo9USU6JRWK=
NCI-H2029 M{i0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTjTWM2OD1yLkKwNlQ{KM7:TR?= MlfnV2FPT0WU
ZR-75-30 NF7zSZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMkC2OFMh|ryP MmfkV2FPT0WU
SW1116 M1fzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;UeYdKSzVyPUCuNlEyOTdizszN NULTfZZsW0GQR1XS
CCRF-CEM MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT0TWM2OD1yLkK3OlE1KM7:TR?= NIj6SIFUSU6JRWK=
LU-135 MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3OT5NKSzVyPUCuNlc4OzlizszN NUXzOZVNW0GQR1XS
MC116 NIriNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;JWmlEPTB;MD6yPFMxQSEQvF2= MX\TRW5ITVJ?
LS-513 MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMki3O|Mh|ryP NIq2OlJUSU6JRWK=
NCI-H630 NWf0UXVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HXXmlEPTB;MD6yPVM4PiEQvF2= NULXU3BHW0GQR1XS
L-428 M{D1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUntcmdWUUN3ME2wMlI6QDh|IN88US=> NGq1TJJUSU6JRWK=
UM-UC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX3TWM2OD1yLkOxNlkyKM7:TR?= MUjTRW5ITVJ?
NCI-H1838 NHzrbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzoUHpCUUN3ME2wMlMyPzh2IN88US=> MoPnV2FPT0WU
HEL MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwM{KyOEDPxE1? MlrUV2FPT0WU
OCI-AML2 NWPUWoltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fzOmlEPTB;MD6zNlI6QCEQvF2= NHXmblRUSU6JRWK=
A3-KAW M4r6cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLnTlhKSzVyPUCuN|M1PzdizszN M2facXNCVkeHUh?=
IGROV-1 NWDJOZBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwM{O3OVUh|ryP NGLZO45USU6JRWK=
Mo-T MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;mTWM2OD1yLkOzPFU{KM7:TR?= M4nlTHNCVkeHUh?=
HDLM-2 M4n0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwM{O5JO69VQ>? M1P1fHNCVkeHUh?=
HCC1569 NU\sZoFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwM{SzNFkh|ryP Ml3jV2FPT0WU
COLO-678 NH;2[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjJbWlKSzVyPUCuN|cxODJizszN M1fafHNCVkeHUh?=
COR-L105 NWWzfWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPQdJF{UUN3ME2wMlM4QTNizszN NVj1PW5uW0GQR1XS
SK-MEL-24 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTVTWM2OD1yLkO4N|gzKM7:TR?= NHHUU5FUSU6JRWK=
COLO-320-HSR Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS0TWM2OD1yLkSzPVc3KM7:TR?= M1vRbHNCVkeHUh?=
C8166 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwNEmwNlMh|ryP NHLtXIpUSU6JRWK=
COLO-679 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjrUVJKSzVyPUCuOlIyPzJizszN NHn5V49USU6JRWK=
TE-12 M1;OOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHRTWM2OD1yLk[1N|k1KM7:TR?= M3rYNHNCVkeHUh?=
HAL-01 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y4dGlEPTB;MD62OlIzKM7:TR?= NVnwR5NwW0GQR1XS
H-EMC-SS NEezW5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTLTWM2OD1yLkewOVQ3KM7:TR?= NWHE[3VHW0GQR1XS
SNU-449 NISy[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO4fo9QUUN3ME2wMlczPzR6IN88US=> MX3TRW5ITVJ?
C32 M{[wXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXZTWM2OD1yLke0NVEzKM7:TR?= M3P1UnNCVkeHUh?=
K-562 NYHnRlhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG5c3FMUUN3ME2wMlc4ODJ2IN88US=> MmXMV2FPT0WU
DJM-1 M3TEZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwN{i3PFEh|ryP MkLlV2FPT0WU
RCC10RGB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi1VpJKSzVyPUCuO|kyQDNizszN MnPFV2FPT0WU
CAL-85-1 NULWRVlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwOUC3JO69VQ>? NIPRboRUSU6JRWK=
NY M1LNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPk[21KSzVyPUCuPVM{PTJizszN NHHL[Y5USU6JRWK=
NCI-H1993 M2nKWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\SZ|BKSzVyPUGuNVkzQDlizszN MULTRW5ITVJ?
SK-OV-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHzTWM2OD1zLkKyNFg6KM7:TR?= NITFRlhUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
体内研究 Docetaxel (33 mg/kg/dose, 静脉注射,每四天注射3次) 处理M2OL2 结肠移植瘤,结果肿瘤生长延迟19.3。Docetaxel作用于MX-1, SK-MEL-2, LX-1 和 OVCAR-3 移植瘤,也具有很强的抗肿瘤活性。Docetaxel抑制成纤维细胞生长因子2的血管反应,IC50为5.4 mg/kg,Docetaxel按10 mg/kg剂量处理小鼠,在14天期间,每周注射两次,结果血管完全堵塞。Docetaxel对内皮细胞迁移和/或微血管形成具有选择性,因为炎症细胞浸润到基底膜对Docetaxel抑制不太敏感。[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[5]
- 合并
  • Cell lines: 人类胃癌细胞系 MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 天
  • Method: 180 μL培养基中的2000个细胞接种到96孔板中,20 μL 药物溶液同时按一式三份加到每孔中。实验板在37°C下含5% CO2的培养箱中温育3天。在第3天,每孔加入25 μL MTT 试剂。温育4小时后,除去培养基。每孔加入0.2 mL DMSO,使用机械式搅拌机充分混合,溶解形成的MTT-甲臜晶体。在540 nm (OD)处测定吸光值。
    (Only for Reference)
动物实验:[6]
- 合并
  • Animal Models: 携带人类结肠癌移植瘤CX-1的小鼠
  • Formulation: 50 mg/mL储存液溶于乙醇,加入同等体积的聚山梨酯 80,然后使用 溶于水的5% 葡萄糖稀释到最终体积。
  • Dosages: 33 mg/kg
  • Administration: 静脉注射,每四天注射3次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
2mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 807.88
化学式

C43H53NO14

CAS号 114977-28-5
储存条件 粉状
溶于溶剂
别名 RP56976, NSC 628503

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04113005 Not yet recruiting Drug: Desmopressin Castrate Resistance Prostate Cancer Sunnybrook Health Sciences Centre|Sunnybrook Research Institute October 1 2019 Early Phase 1
NCT03700099 Recruiting Drug: Docetaxel|Drug: Enzalutamide Prostate Cancer|Castration-resistant Prostate Cancer Instituto do Cancer do Estado de São Paulo|Astellas Pharma Inc September 3 2019 Phase 2
NCT04067713 Recruiting -- Metastatic Prostate Cancer University College London|Epic Sciences September 20 2019 --
NCT03976375 Recruiting Biological: Pembrolizumab|Drug: Lenvatinib|Drug: Docetaxel Metastatic Non-Small Cell Lung Cancer Merck Sharp & Dohme Corp.|Eisai Inc. June 26 2019 Phase 3

技术支持

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操作手册

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID