Docetaxel

目录号:S1148 别名: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。

规格 价格 库存 购买数量  
In DMSO RMB 746.97 现货
RMB 563.39 现货
RMB 2233.96 现货
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客户使用Selleck该产品发表文献56篇:

产品安全说明书

Microtubule Associated抑制剂选择性比较

生物活性

产品描述 Docetaxel多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。
靶点
Microtubules [1]
(Cell-free assay)
体外研究

Docetaxel是一种细胞毒性剂,尤其对于增殖细胞,Docetaxel促进微管蛋白束的形成,还能诱导持续的有丝分裂阻滞,随后分裂阻滞的细胞凋亡或永久抑制分裂。 Docetaxel抑制微管的动态不稳定性及踏车现象,导致染色体不能分开到子细胞中,这样又会反过来触发有丝分裂过早结束,而不是在细胞周期的特定时期进行抑制作用。[2] Docetaxel (150 ng/mL) 处理人类小细胞肺癌 N417细胞系 1小时,抑制50% 细胞生长。 Docetaxel 处理 KB 人类表皮癌细胞, T24 人类膀胱癌细胞, Calc18 人类乳腺癌细胞, 和HCT116人类结肠腺癌96-120小时,IC50值分别为8 ng/mL, 4 ng/mL, 5 ng/mL, 和 7 ng/mL。[3] Docetaxel 处理人类癌细胞Hs746T (胃), AGS (胃), HeLa (子宫颈), CaSki (子宫颈), BxPC3 (胰腺), Capan-1 (胰腺) 24小时,抑制克隆存活,IC50 分别为 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM, 0.3 nM。[4] 通过克隆形成实验测评Docetaxel处理人类 卵巢癌细胞系 OVCA432, A2780, A2780/cp8 12天期间,IC50值分别达到0.06 nM, 0.6 nM, 和3 nM。[5]Docetaxel 作用于9种培养的人类胃癌细胞系 (MKN-7, -28, -45, NUGC-4 和KATO-III, ST-SA-1, NAKAJIMA 和ST-KM, KKLS)时,IC50 分别为 >1.2 μM, 0.6 nM, 0.1 nM, 3.5 nM, 4 nM, 99 nM, 0.3 nM,0.5 nM, 0.9 nM。[6]在体外,Docetaxel在极低浓度时,抑制内皮细胞迁移,这并不影响微管的大体形态或抑制细胞增殖,对微管动力学产生更微妙的影响。Docetaxel 抑制 HUVEC 迁移,IC50 为1 pM。Docetaxel 抑制血管生成因子胸甘磷酸化酶或血管内皮生长因子刺激的HUVEC趋化性,IC 50 为10 pM 。[7] Docetaxel (30 μM) 在添加10%人血清的培养基中温育12小时,诱导人单核细胞。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 M2rQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMECwNVMzKM7:TR?= NEHKR2pUSU6JRWK=
5637 NWTxdVN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\5PGlEPTB;MD6wNFAyPDNizszN MX\TRW5ITVJ?
HT-144 M3;OXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\NTWM2OD1yLkCwNFE2PyEQvF2= M4\qZnNCVkeHUh?=
NCI-H292 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu2N3RKSzVyPUCuNFAxOTV7IN88US=> Mm\EV2FPT0WU
HCE-T NVH3SHROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz0R|B[UUN3ME2wMlAxODF4MjFOwG0> NXnPZZd3W0GQR1XS
ESS-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3pe|dNUUN3ME2wMlAxODF5OTFOwG0> NFrY[WNUSU6JRWK=
D-566MG NXjreJBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMECwNVgzKM7:TR?= NWi3XJVbW0GQR1XS
CAL-62 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMECwNVg2KM7:TR?= NWPqcWZrW0GQR1XS
GT3TKB NWS0bI5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37TZWlEPTB;MD6wNFAzOzJizszN MlnnV2FPT0WU
HSC-4 NXntV2NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMECwNlM6KM7:TR?= Mnj6V2FPT0WU
KOSC-2 MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\CPGlEPTB;MD6wNFAzPTVizszN MmLyV2FPT0WU
NB14 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLGTWM2OD1yLkCwNFI3KM7:TR?= M4DXR3NCVkeHUh?=
ES8 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e1OGlEPTB;MD6wNFAzPiEQvF2= NWHJOYU5W0GQR1XS
BFTC-905 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMECwNlY5KM7:TR?= M3rKWnNCVkeHUh?=
A498 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPkVZJ3UUN3ME2wMlAxODJ5ODFOwG0> NUCwfVZwW0GQR1XS
HO-1-N-1 M2jMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K1cmlEPTB;MD6wNFAzQDFizszN MmHyV2FPT0WU
SF539 NHLZclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PzWmlEPTB;MD6wNFA{ODJizszN Mk\mV2FPT0WU
HuO-3N1 MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m3SGlEPTB;MD6wNFA{ODJizszN M1PEbHNCVkeHUh?=
NCI-H510A M33rSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvkNIxKSzVyPUCuNFAxOzN4IN88US=> NFHyN|hUSU6JRWK=
CAL-27 Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmWxTWM2OD1yLkCwNFM{QSEQvF2= MUHTRW5ITVJ?
TE-8 NXr5WINXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;kUWJKSzVyPUCuNFAxOzZ4IN88US=> M1:2dnNCVkeHUh?=
VA-ES-BJ NWLLOIYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jlTmlEPTB;MD6wNFA{PzVizszN M3WwUnNCVkeHUh?=
RH-1 Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLLWFJKSzVyPUCuNFAxOzh4IN88US=> MnTtV2FPT0WU
COLO-800 M1zVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILsPYNKSzVyPUCuNFAxOzh6IN88US=> M4HI[XNCVkeHUh?=
ES7 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDKTWM2OD1yLkCwNFM5QSEQvF2= M2PjNXNCVkeHUh?=
GAMG NVvUWGo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H2VmlEPTB;MD6wNFA1OTZizszN MkD2V2FPT0WU
Ca9-22 NV3rdmNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHxTWM2OD1yLkCwNFQzOyEQvF2= NFnm[IFUSU6JRWK=
SBC-1 NXrpdI1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jjcWlEPTB;MD6wNFA1OyEQvF2= MXfTRW5ITVJ?
RPMI-7951 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPD[3hKSzVyPUCuNFAxPDR6IN88US=> MmnTV2FPT0WU
SW1710 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\PTWZKSzVyPUCuNFAxPDZ4IN88US=> MXXTRW5ITVJ?
HGC-27 M3jwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMECwOFcyKM7:TR?= M1WyVnNCVkeHUh?=
MC-IXC NEPNepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMECwOFc6KM7:TR?= MYjTRW5ITVJ?
FTC-133 NGLXWmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f6PWlEPTB;MD6wNFA1QDlizszN MYLTRW5ITVJ?
HT-1080 M4\Bdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMECwOVAyKM7:TR?= M2jkSXNCVkeHUh?=
NMC-G1 NVL3c4VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHBT|JiUUN3ME2wMlAxODVzNzFOwG0> NGXh[GtUSU6JRWK=
GI-1 M2\ubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMECwOVI5KM7:TR?= MnzUV2FPT0WU
CGTH-W-1 MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fuZmlEPTB;MD6wNFA2PDJizszN MVXTRW5ITVJ?
A2058 NHvIXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq1WW1UUUN3ME2wMlAxODV2NDFOwG0> NHXXT3hUSU6JRWK=
ETK-1 MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXzemlKSzVyPUCuNFAxPTV6IN88US=> MoHNV2FPT0WU
NEC8 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPnNFNoUUN3ME2wMlAxODV4MTFOwG0> NFX1ZVZUSU6JRWK=
TE-11 M1XrRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFj6WXRKSzVyPUCuNFAxPTZ7IN88US=> Mn2xV2FPT0WU
NCI-H720 M3\ufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnZN4JoUUN3ME2wMlAxODV6IN88US=> NXT5fFkyW0GQR1XS
PSN1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17oRWlEPTB;MD6wNFA2QDFizszN M4LxTXNCVkeHUh?=
SW780 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL0TWM2OD1yLkCwNFU5PyEQvF2= MYrTRW5ITVJ?
8-MG-BA NGjwVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[5Z|k3UUN3ME2wMlAxODV6OTFOwG0> MmjCV2FPT0WU
EC-GI-10 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M175TmlEPTB;MD6wNFA2QTJizszN NX:3SZBJW0GQR1XS
SJSA-1 M4XRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXOTWM2OD1yLkCwNFYyPSEQvF2= NEj2coVUSU6JRWK=
639-V NHj2fIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f4d2lEPTB;MD6wNFA3PDdizszN M3nBUnNCVkeHUh?=
PFSK-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHyZol4UUN3ME2wMlAxODZ3NzFOwG0> NIjPUYNUSU6JRWK=
DMS-273 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMECwOlc1KM7:TR?= NX:yOFB1W0GQR1XS
TE-9 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMECwOlc3KM7:TR?= MV3TRW5ITVJ?
SCC-25 NILSN2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PObWlEPTB;MD6wNFA3QCEQvF2= NIL1[pZUSU6JRWK=
PA-1 M2W5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPJfmtKSzVyPUCuNFAxPjh5IN88US=> MVrTRW5ITVJ?
MHH-ES-1 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\je2lwUUN3ME2wMlAxODdizszN MV7TRW5ITVJ?
Daoy M3ez[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\tTWM2OD1yLkCwNFch|ryP MX3TRW5ITVJ?
G-402 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;0VmlEPTB;MD6wNFA4ODZizszN NFnkXnhUSU6JRWK=
YKG-1 M4j4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXiyTpEzUUN3ME2wMlAxODdyNzFOwG0> M{W5b3NCVkeHUh?=
Ca-Ski NYf3e5JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXOTWM2OD1yLkCwNFczQCEQvF2= M1f1XnNCVkeHUh?=
CHP-212 NV;GUmp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHNTWM2OD1yLkCwNFc{KM7:TR?= NFHZdmFUSU6JRWK=
SCC-4 M1zrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPLTWM2OD1yLkCwNFc{QSEQvF2= NXXSeIcxW0GQR1XS
EW-3 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMECwO|Q2KM7:TR?= MW\TRW5ITVJ?
P12-ICHIKAWA M{[zdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHNXHBKSzVyPUCuNFAxPzR3IN88US=> NUjBc5JPW0GQR1XS
HSC-2 NUCyW3E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPLeG5DUUN3ME2wMlAxODd3NTFOwG0> NH7XU3ZUSU6JRWK=
HN NUDCOotDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37wZ2lEPTB;MD6wNFA4PThizszN MoLMV2FPT0WU
LXF-289 NEnoUpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonvTWM2OD1yLkCwNFc2QCEQvF2= NFjW[4hUSU6JRWK=
ES1 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrQfJhKSzVyPUCuNFAxPzdizszN NUPRfIR6W0GQR1XS
NTERA-S-cl-D1 M{W0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nUSWlEPTB;MD6wNFA4PzNizszN NUnpUGhYW0GQR1XS
K5 M2e4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTBV3hKSzVyPUCuNFAxPzd6IN88US=> Mki0V2FPT0WU
HOS MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTpTWM2OD1yLkCwNFc5OiEQvF2= MkPzV2FPT0WU
YH-13 NIfMRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvNTWM2OD1yLkCwNFc6OSEQvF2= NWe2XG9qW0GQR1XS
SW954 M3rTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjOe|NKSzVyPUCuNFAxQDJ|IN88US=> M2rCdHNCVkeHUh?=
KYSE-510 NGLOUIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLHN2hzUUN3ME2wMlAxODh2IN88US=> MkLvV2FPT0WU
8505C NGjQTWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUexNXVoUUN3ME2wMlAxODh3NDFOwG0> NVW4NJJIW0GQR1XS
A549 NFTUe3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf3TWM2OD1yLkCwNFg5OiEQvF2= MVTTRW5ITVJ?
Detroit562 NFHhbo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7HNYtKSzVyPUCuNFAxQTB{IN88US=> NVvmWJplW0GQR1XS
ES5 NGPwWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknWTWM2OD1yLkCwNFkyKM7:TR?= MWrTRW5ITVJ?
KYSE-140 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMECwPVM{KM7:TR?= MYPTRW5ITVJ?
GMS-10 NX2zOpN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnjcGhGUUN3ME2wMlAxODl2MTFOwG0> MofpV2FPT0WU
D-263MG NU\J[ZVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr6TWM2OD1yLkCwNFk1PyEQvF2= NITKcJBUSU6JRWK=
BCPAP MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMECwPVQ4KM7:TR?= NYjSVm5pW0GQR1XS
CHL-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXpZ|RKSzVyPUCuNFAxQTV6IN88US=> MWfTRW5ITVJ?
RKO NYXiOYxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnq4TWM2OD1yLkCwNFk5QSEQvF2= NFHvZ4pUSU6JRWK=
SW48 M1f6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjTTWM2OD1yLkCwNVAyKM7:TR?= NHSycodUSU6JRWK=
BPH-1 NIf2ZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTHc243UUN3ME2wMlAxOTB{IN88US=> MVvTRW5ITVJ?
EFO-27 NHHIXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMECxNFIh|ryP M1X4bnNCVkeHUh?=
CAL-33 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMECxNFQh|ryP NGG4N4ZUSU6JRWK=
NCI-H1792 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK1[GFKSzVyPUCuNFAyODRizszN NFLxVVdUSU6JRWK=
BB30-HNC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMECxNFUh|ryP NHuzOGZUSU6JRWK=
VM-CUB-1 MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLrTWM2OD1yLkCwNVA2KM7:TR?= MkPMV2FPT0WU
TE-5 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMECxNFYh|ryP MXvTRW5ITVJ?
NB13 M3q3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPuTWM2OD1yLkCwNVA4KM7:TR?= M{\5V3NCVkeHUh?=
NBsusSR MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17XSGlEPTB;MD6wNFEyKM7:TR?= M1vMVXNCVkeHUh?=
LNCaP-Clone-FGC MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMECxNUDPxE1? NH2xeG1USU6JRWK=
EPLC-272H Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrCO3BkUUN3ME2wMlAxOTFzIN88US=> MmnvV2FPT0WU
KNS-62 NH7HU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\2TWM2OD1yLkCwNVEzKM7:TR?= MWjTRW5ITVJ?
RERF-LC-MS MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMECxNVMh|ryP NEDl[nFUSU6JRWK=
LOXIMVI NXLmb2tsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrSR3BKSzVyPUCuNFAyOTZizszN NFi4PVBUSU6JRWK=
KINGS-1 MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLLTWM2OD1yLkCwNVE4KM7:TR?= MmfSV2FPT0WU
T98G NH;PXXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG0OnBQUUN3ME2wMlAxOTF5IN88US=> MULTRW5ITVJ?
HCC1806 M33jdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;yTWM2OD1yLkCwNVE5KM7:TR?= NH\hfJlUSU6JRWK=
MZ1-PC M4fkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\RSmdKSzVyPUCuNFAyOThizszN M2jSR3NCVkeHUh?=
RT-112 NELXcXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMECxNVkh|ryP MUfTRW5ITVJ?
LK-2 M4LSRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMECxNlEh|ryP NF7pUIFUSU6JRWK=
A375 M2rtfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\hN2lEPTB;MD6wNFEzOSEQvF2= M2fXR3NCVkeHUh?=
SF268 M{fxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfhZY0xUUN3ME2wMlAxOTJzIN88US=> MWjTRW5ITVJ?
H9 MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX60RWp1UUN3ME2wMlAxOTJ2IN88US=> NG[1OolUSU6JRWK=
KYSE-410 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XDXGlEPTB;MD6wNFEzPCEQvF2= NVnMXGVWW0GQR1XS
G-401 M1zrW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP1TWxWUUN3ME2wMlAxOTJ5IN88US=> NHPOfI1USU6JRWK=
SW982 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[5R2lEPTB;MD6wNFEzPyEQvF2= NEjCPFRUSU6JRWK=
D-423MG NYPLeWU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfsTWM2OD1yLkCwNVMh|ryP NHrIZ|JUSU6JRWK=
CAMA-1 M1HRV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMECxN|Eh|ryP NWnodWV1W0GQR1XS
SCC-9 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvzTWM2OD1yLkCwNVMzKM7:TR?= NFPwNYpUSU6JRWK=
SAS Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj5TWM2OD1yLkCwNVM1KM7:TR?= NH7lW29USU6JRWK=
KYSE-180 MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMECxN|Uh|ryP MWrTRW5ITVJ?
EW-16 NH7Zc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S2cWlEPTB;MD6wNFE{PSEQvF2= NE[2enNUSU6JRWK=
HD-MY-Z M2q0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfvN254UUN3ME2wMlAxOTRzIN88US=> Mn7oV2FPT0WU
KYSE-450 NVrhSpBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fTNGlEPTB;MD6wNFE1OyEQvF2= Ml\uV2FPT0WU
LCLC-97TM1 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnXbVNHUUN3ME2wMlAxOTR2IN88US=> NHj4SlVUSU6JRWK=
KS-1 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r0dmlEPTB;MD6wNFE1PCEQvF2= M{LHd3NCVkeHUh?=
TI-73 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOzTWM2OD1yLkCwNVQ1KM7:TR?= MUjTRW5ITVJ?
A427 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fDWGlEPTB;MD6wNFE1QCEQvF2= NHrS[JZUSU6JRWK=
LB831-BLC MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnhfHFKSzVyPUCuNFAyPDhizszN NUnENZJsW0GQR1XS
MG-63 NGnhe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXRSlRGUUN3ME2wMlAxOTVzIN88US=> MVnTRW5ITVJ?
PANC-03-27 NEHYc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfCXXNKSzVyPUCuNFAyPTRizszN NYezXJV6W0GQR1XS
23132-87 M{\rZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jT[WlEPTB;MD6wNFE2PSEQvF2= NE\ifWhUSU6JRWK=
ES4 M1jqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfOWXpKSzVyPUCuNFAyPTVizszN NVLuRVc1W0GQR1XS
KP-4 NFm3OXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMECxOVYh|ryP NHr3d3FUSU6JRWK=
NCI-H1703 NHjmWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\oTWM2OD1yLkCwNVU4KM7:TR?= NF2xfXFUSU6JRWK=
MCF7 MkLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMECxOlEh|ryP M{HMWHNCVkeHUh?=
A172 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fBdGlEPTB;MD6wNFE3OyEQvF2= M3;0O3NCVkeHUh?=
CAL-39 NGDCbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;VUWlEPTB;MD6wNFE3OyEQvF2= M3Xt[XNCVkeHUh?=
Saos-2 M1\hUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PJNmlEPTB;MD6wNFE3QCEQvF2= NHv0N5dUSU6JRWK=
EW-11 NFjNVFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS1[I02UUN3ME2wMlAxOTZ7IN88US=> NFH1NW5USU6JRWK=
D-336MG NVvRV29TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fNd2lEPTB;MD6wNFE3QSEQvF2= Ml\TV2FPT0WU
SW13 NIDqO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfBdFdKSzVyPUCuNFAyPjlizszN MnnQV2FPT0WU
ME-180 M2\6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHWTWM2OD1yLkCwNVY6KM7:TR?= NUTxNldjW0GQR1XS
SK-MEL-2 NV\rXIZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLadXRiUUN3ME2wMlAxOTdizszN Ml\jV2FPT0WU
697 NGHPNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD0ZlBKSzVyPUCuNFAyPzJizszN MmWwV2FPT0WU
D-247MG M1fkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMECxO|Mh|ryP MUfTRW5ITVJ?
EoL-1-cell NX7OVJR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPYTWM2OD1yLkCwNVc{KM7:TR?= MUPTRW5ITVJ?
MV-4-11 NYjR[YI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HBe2lEPTB;MD6wNFE4PCEQvF2= NYT4S4k3W0GQR1XS
U-2-OS M1XqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDuTWM2OD1yLkCwNVc2KM7:TR?= MU\TRW5ITVJ?
NCI-H526 M1nsfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKyOYJKSzVyPUCuNFAyPzZizszN Mm\DV2FPT0WU
SK-NEP-1 M4jkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\hTWM2OD1yLkCwNVc3KM7:TR?= NYrsZ4dUW0GQR1XS
DB Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHud2JzUUN3ME2wMlAxOTd6IN88US=> NFHvbY9USU6JRWK=
GCT MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMECxPEDPxE1? NWH6UVR[W0GQR1XS
HCT-116 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrtWmpyUUN3ME2wMlAxOThzIN88US=> MkXYV2FPT0WU
AU565 MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMECxPFEh|ryP NH;sUGJUSU6JRWK=
KALS-1 M4rhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnkOIduUUN3ME2wMlAxOThzIN88US=> NYnxZ5p6W0GQR1XS
C2BBe1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLFTphEUUN3ME2wMlAxOTh{IN88US=> Mny5V2FPT0WU
Becker MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vHZWlEPTB;MD6wNFE5OyEQvF2= MmDKV2FPT0WU
647-V MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPtTWM2OD1yLkCwNVg1KM7:TR?= NYTtWpFiW0GQR1XS
NCI-H2122 NXfJe4tHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37RfmlEPTB;MD6wNFE5PCEQvF2= MnjiV2FPT0WU
SBC-5 NVyy[JJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLKV2tKSzVyPUCuNFAyQDdizszN NVHMU|REW0GQR1XS
NB17 M4Twe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMECxPFkh|ryP NXnCd5RpW0GQR1XS
MHH-PREB-1 MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPzNVNVUUN3ME2wMlAxOTh7IN88US=> NHHJUo1USU6JRWK=
M14 M2TEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMECxPVEh|ryP M1PFeXNCVkeHUh?=
NCI-H1048 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DP[mlEPTB;MD6wNFE6OiEQvF2= NEDRRotUSU6JRWK=
CTB-1 MmXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M125RmlEPTB;MD6wNFE6OiEQvF2= NVO4NpdrW0GQR1XS
SK-PN-DW MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMECxPVQh|ryP NIHtPWdUSU6JRWK=
H4 MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\pOoxjUUN3ME2wMlAxOTl4IN88US=> M3TMS3NCVkeHUh?=
NCI-SNU-1 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUThcFFuUUN3ME2wMlAxOTl5IN88US=> NVfBXnpXW0GQR1XS
M059J NFm5PIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLMTWM2OD1yLkCwNVk5KM7:TR?= NVS1PVExW0GQR1XS
OVCAR-5 NGXBS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMECxPVkh|ryP MYPTRW5ITVJ?
SK-MEL-28 MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nOZWlEPTB;MD6wNFIxOyEQvF2= M4\OVHNCVkeHUh?=
PC-14 NWDkN3FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDrfYpiUUN3ME2wMlAxOjB7IN88US=> NYK1U4I2W0GQR1XS
OVCAR-8 MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jmUGlEPTB;MD6wNFIyOiEQvF2= NIPTfo9USU6JRWK=
BB49-HNC MoizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPIN5JyUUN3ME2wMlAxOjF{IN88US=> M2SxW3NCVkeHUh?=
EFM-19 MmLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjlTWM2OD1yLkCwNlE2KM7:TR?= MXrTRW5ITVJ?
BHY MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\iTWM2OD1yLkCwNlE3KM7:TR?= MXzTRW5ITVJ?
SW756 MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPsbYpKSzVyPUCuNFAzOTZizszN MULTRW5ITVJ?
TE-1 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfMTWM2OD1yLkCwNlE3KM7:TR?= M1;vZ3NCVkeHUh?=
NCI-H2452 MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMECyNVYh|ryP NETDV3hUSU6JRWK=
NCI-H1581 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjm[Iw5UUN3ME2wMlAxOjF5IN88US=> NUHDbYxwW0GQR1XS
COR-L23 NF\PNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnvXFBXUUN3ME2wMlAxOjJizszN MYfTRW5ITVJ?
RXF393 M3;IS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSydGxKSzVyPUCuNFAzOjJizszN M3qyN3NCVkeHUh?=
BFTC-909 NUTQTmlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZWJA2UUN3ME2wMlAxOjJ3IN88US=> M4fqR3NCVkeHUh?=
IST-MEL1 NVTvS4cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzLRlNKSzVyPUCuNFAzOjVizszN NYLBbpJoW0GQR1XS
NCI-H650 NWXkUIp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3xU2xKSzVyPUCuNFAzOjVizszN Mn7EV2FPT0WU
SK-UT-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMECyNlYh|ryP M2Ozd3NCVkeHUh?=
GOTO NY[4R|VuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkGzTWM2OD1yLkCwNlI4KM7:TR?= NGjnXmVUSU6JRWK=
TYK-nu NV;5[FN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrETWM2OD1yLkCwNlMzKM7:TR?= NYLJSVJZW0GQR1XS
JVM-3 NH70bW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:2T4tKSzVyPUCuNFAzOzNizszN Ml7ZV2FPT0WU
SK-MES-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXjXnVvUUN3ME2wMlAxOjN|IN88US=> M{D3NnNCVkeHUh?=
SK-HEP-1 M17v[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfpTWM2OD1yLkCwNlM1KM7:TR?= MUPTRW5ITVJ?
J-RT3-T3-5 NFK4V41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPkTWM2OD1yLkCwNlM2KM7:TR?= MV\TRW5ITVJ?
A673 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\NOoZnUUN3ME2wMlAxOjN3IN88US=> MWPTRW5ITVJ?
NCI-H446 NG[wOndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3izbWlEPTB;MD6wNFI1OyEQvF2= MVXTRW5ITVJ?
RPMI-2650 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC3S3hKSzVyPUCuNFAzPDZizszN NUPpbmpGW0GQR1XS
HCE-4 MlLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn62TWM2OD1yLkCwNlQ4KM7:TR?= MWLTRW5ITVJ?
KGN NIPMbZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:0eYFKSzVyPUCuNFAzPDdizszN MX3TRW5ITVJ?
U251 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH1TWM2OD1yLkCwNlUh|ryP MnX5V2FPT0WU
BxPC-3 NH;yVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;TRXVKSzVyPUCuNFAzPTFizszN M{HjbHNCVkeHUh?=
VMRC-RCZ MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X0TmlEPTB;MD6wNFI2OiEQvF2= NWr4VHVQW0GQR1XS
TE-10 NVXMSZU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMECyOVQh|ryP NY\DVVhwW0GQR1XS
OC-314 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMECyOVYh|ryP MmLQV2FPT0WU
NCI-H1437 M{jle2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMECyOkDPxE1? M{XuSXNCVkeHUh?=
SNU-387 NFHUZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMECyOlEh|ryP MmLxV2FPT0WU
A388 M4jVR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjmRnVKSzVyPUCuNFAzPjVizszN MoHqV2FPT0WU
C-33-A NUfpRW5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\sUGlEPTB;MD6wNFI3PiEQvF2= M1m3b3NCVkeHUh?=
CAL-51 NXPzem14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMECyO|Eh|ryP MUTTRW5ITVJ?
Hs-578-T Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoC3TWM2OD1yLkCwNlczKM7:TR?= NYTBZotwW0GQR1XS
MDA-MB-415 M2HmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvVTWM2OD1yLkCwNlc1KM7:TR?= M4LqeHNCVkeHUh?=
SW1417 MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMECyO|Yh|ryP NFLm[5RUSU6JRWK=
HCC70 M2H2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfHTWM2OD1yLkCwNlc4KM7:TR?= MmXLV2FPT0WU
ES3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL0PHVKSzVyPUCuNFAzPzdizszN MlniV2FPT0WU
KYSE-270 NYPEUoY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\5NmFCUUN3ME2wMlAxOjd6IN88US=> Mn:4V2FPT0WU
HT-29 NG\SPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMECyPEDPxE1? MnPSV2FPT0WU
MDA-MB-361 M4m5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTHeZBKSzVyPUCuNFAzQDFizszN MXnTRW5ITVJ?
RPMI-8866 NH2zTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nFdWlEPTB;MD6wNFI5OSEQvF2= NGDTV49USU6JRWK=
JEG-3 M2XLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMECyPFIh|ryP MnzYV2FPT0WU
HT-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXVbXZKSzVyPUCuNFAzQDJizszN M3vzVnNCVkeHUh?=
HTC-C3 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\nTWM2OD1yLkCwNlg2KM7:TR?= M1jWXHNCVkeHUh?=
NCI-H209 M3j5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfGV|F7UUN3ME2wMlAxOjh4IN88US=> NXva[VBOW0GQR1XS
SKG-IIIa M1n0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XFOWlEPTB;MD6wNFI5PiEQvF2= M4e1[XNCVkeHUh?=
SW962 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMECyPVMh|ryP MUfTRW5ITVJ?
LCLC-103H Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMECyPVMh|ryP NWnQbm1ZW0GQR1XS
DOK MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMECyPVQh|ryP M4HKSnNCVkeHUh?=
SW1088 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP3fY1IUUN3ME2wMlAxOjl3IN88US=> NWXtSYRHW0GQR1XS
GP5d NVvjfFNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\DTWM2OD1yLkCwNlk3KM7:TR?= MnewV2FPT0WU
EW-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMECyPVgh|ryP MYHTRW5ITVJ?
CP66-MEL NF7mNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMECzJO69VQ>? M2XJXXNCVkeHUh?=
DEL NH3IWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzQUotvUUN3ME2wMlAxOzBzIN88US=> MWHTRW5ITVJ?
DU-4475 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f6TmlEPTB;MD6wNFMxOiEQvF2= NELUPHhUSU6JRWK=
HEC-1 M1LLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr1PXRKSzVyPUCuNFA{ODNizszN M1HENXNCVkeHUh?=
U031 NEnxSZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMECzNFch|ryP MWfTRW5ITVJ?
BB65-RCC M{XVcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi4Rog6UUN3ME2wMlAxOzB6IN88US=> MUnTRW5ITVJ?
NUGC-3 M3HWOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTUcXNKSzVyPUCuNFA{ODhizszN M17mcHNCVkeHUh?=
IST-SL1 NX7OZ4hLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMECzNVIh|ryP NEi4SpVUSU6JRWK=
LS-411N NFS0elVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMECzNVQh|ryP Mk[zV2FPT0WU
22RV1 NGn6UIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnPfng4UUN3ME2wMlAxOzF3IN88US=> NHj6[W1USU6JRWK=
MKN28 NXG4WGppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vQ[WlEPTB;MD6wNFMyPyEQvF2= MkKyV2FPT0WU
ONS-76 Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmGyTWM2OD1yLkCwN|IzKM7:TR?= NWPS[ZpMW0GQR1XS
SH-4 NEX5[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG3TWJkUUN3ME2wMlAxOzJ{IN88US=> M1fBenNCVkeHUh?=
MIA-PaCa-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f1PGlEPTB;MD6wNFMzPCEQvF2= M1jh[XNCVkeHUh?=
CaR-1 MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMECzNlch|ryP M2qwTHNCVkeHUh?=
AGS MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H0SGlEPTB;MD6wNFMzQCEQvF2= M{i2cHNCVkeHUh?=
SF126 NXztSGFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofHTWM2OD1yLkCwN|I6KM7:TR?= MULTRW5ITVJ?
UACC-62 NEfHeIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkiwTWM2OD1yLkCwN|Mh|ryP MYHTRW5ITVJ?
NCI-H28 NHLYb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnFTWM2OD1yLkCwN|M1KM7:TR?= Mon4V2FPT0WU
A2780 MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi5d4dKSzVyPUCuNFA{OzVizszN MXPTRW5ITVJ?
CTV-1 NFLscmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMECzN|ch|ryP NVuyWXpzW0GQR1XS
LC-2-ad M3rxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;RT2lEPTB;MD6wNFM1KM7:TR?= M{O2cXNCVkeHUh?=
NCI-H1770 M1HTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jCeGlEPTB;MD6wNFM1OiEQvF2= MYXTRW5ITVJ?
HuO9 NW\rS41bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHuPGVLUUN3ME2wMlAxOzR4IN88US=> MUTTRW5ITVJ?
U-266 M1vrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrac3dqUUN3ME2wMlAxOzR6IN88US=> NVniVoFFW0GQR1XS
MLMA NYXTXYxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMECzOVUh|ryP M{jid3NCVkeHUh?=
U-87-MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rBOWlEPTB;MD6wNFM2PSEQvF2= M3PNb3NCVkeHUh?=
GI-ME-N MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml31TWM2OD1yLkCwN|U5KM7:TR?= NE\FUVhUSU6JRWK=
HL-60 M3X6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3E[YhKSzVyPUCuNFA{PTlizszN MWDTRW5ITVJ?
EGI-1 NE\mXJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMECzOlIh|ryP M4PCR3NCVkeHUh?=
NCI-H23 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLJTWM2OD1yLkCwN|Y1KM7:TR?= NXfTOIVNW0GQR1XS
NCI-H226 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMECzOlgh|ryP M{nxRnNCVkeHUh?=
NCI-H520 NHrzeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{naWmlEPTB;MD6wNFM4OiEQvF2= M2PvW3NCVkeHUh?=
L-363 MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3pTWM2OD1yLkCwN|c3KM7:TR?= MoexV2FPT0WU
CAL-12T Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\ofYpKSzVyPUCuNFA{PzZizszN MlnTV2FPT0WU
BT-20 M4j0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn74TWM2OD1yLkCwN|c3KM7:TR?= NIfWUmZUSU6JRWK=
SNB75 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nkPWlEPTB;MD6wNFM5OSEQvF2= NHLlRmNUSU6JRWK=
A4-Fuk MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMECzPUDPxE1? MULTRW5ITVJ?
BE-13 Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HLPWlEPTB;MD6wNFM6OyEQvF2= M4K3b3NCVkeHUh?=
NCI-H1395 NX;zT|VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMECzPVYh|ryP MlPjV2FPT0WU
SW620 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\ITWM2OD1yLkCwN|k4KM7:TR?= MYHTRW5ITVJ?
KNS-81-FD NEey[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\EW21KSzVyPUCuNFA{QTlizszN MYjTRW5ITVJ?
RD MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG0TWM2OD1yLkCwOEDPxE1? MmD6V2FPT0WU
HLE MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEC0NFUh|ryP NH7vXXJUSU6JRWK=
OVCAR-3 M2HtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\ENnI4UUN3ME2wMlAxPDB5IN88US=> MlvYV2FPT0WU
KM12 MnzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XQTmlEPTB;MD6wNFQxQCEQvF2= M4jrenNCVkeHUh?=
HCC2998 M1jlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PwfWlEPTB;MD6wNFQxQCEQvF2= M2H3N3NCVkeHUh?=
D-502MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHXT4NTUUN3ME2wMlAxPDFizszN MV;TRW5ITVJ?
KNS-42 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEC0NVIh|ryP MVTTRW5ITVJ?
LS-123 NVnBXJpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[yRXpWUUN3ME2wMlAxPDJ3IN88US=> MVzTRW5ITVJ?
SiHa NHHhU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf4Z3JKSzVyPUCuNFA1OyEQvF2= NWXLbJc5W0GQR1XS
T47D MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\OeWlEPTB;MD6wNFQ{OSEQvF2= M4LUb3NCVkeHUh?=
EW-24 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHEcpRyUUN3ME2wMlAxPDN|IN88US=> M{XjXnNCVkeHUh?=
CAL-120 NW\uRlBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP3SHJKSzVyPUCuNFA1OzVizszN NH25d2dUSU6JRWK=
JAR NW\XenJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LmU2lEPTB;MD6wNFQ{PyEQvF2= NXHofWxKW0GQR1XS
QIMR-WIL NET2O2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DwOmlEPTB;MD6wNFQ{QCEQvF2= Mn6yV2FPT0WU
OCUB-M NYLn[JU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTaTWM2OD1yLkCwOFM5KM7:TR?= MYTTRW5ITVJ?
Calu-6 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL3TWM2OD1yLkCwOFQ4KM7:TR?= MYPTRW5ITVJ?
MDA-MB-453 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnYNXBsUUN3ME2wMlAxPDVzIN88US=> NUPjcJFSW0GQR1XS
MKN45 NF3UcJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q3SmlEPTB;MD6wNFQ2OyEQvF2= MVnTRW5ITVJ?
ECC10 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEC0OkDPxE1? MUTTRW5ITVJ?
RVH-421 NHe2R5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXDWYFKSzVyPUCuNFA1PjFizszN NEDVeIdUSU6JRWK=
TGBC11TKB NEG3TYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGro[4pKSzVyPUCuNFA1PjlizszN MoLhV2FPT0WU
MOLT-4 M{O5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ToTmlEPTB;MD6wNFQ4OSEQvF2= NH3JR25USU6JRWK=
LN-405 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zXemlEPTB;MD6wNFQ5OiEQvF2= MYXTRW5ITVJ?
S-117 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrpRnhKSzVyPUCuNFA1QDZizszN NHPPTmFUSU6JRWK=
RPMI-8226 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rPcGlEPTB;MD6wNFQ6PyEQvF2= MVPTRW5ITVJ?
KYSE-150 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfGUVdKSzVyPUCuNFA1QTlizszN NIflXnlUSU6JRWK=
NCI-H1666 M{nkWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEC1NFUh|ryP M{LGenNCVkeHUh?=
Mewo MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDqTG9KSzVyPUCuNFA2ODVizszN MVnTRW5ITVJ?
AN3-CA MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEC1NFch|ryP NFWwUoVUSU6JRWK=
COLO-680N NXPsNpdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmS1TWM2OD1yLkCwOVA5KM7:TR?= M1Hje3NCVkeHUh?=
FADU M{THb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\nTWM2OD1yLkCwOVEh|ryP NYrCWZNmW0GQR1XS
GB-1 MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEC1NVEh|ryP M{HqUnNCVkeHUh?=
KASUMI-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvXTWM2OD1yLkCwOVEyKM7:TR?= NXnL[5VXW0GQR1XS
NOMO-1 NIP2XpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvkNVFKSzVyPUCuNFA2OTNizszN NVrQZ48yW0GQR1XS
BV-173 NWLGXGN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q0UWlEPTB;MD6wNFU{KM7:TR?= NH\EUGxUSU6JRWK=
RO82-W-1 NF[1WJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrBe|U{UUN3ME2wMlAxPTNzIN88US=> NWOxO296W0GQR1XS
LB2241-RCC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHTfolSUUN3ME2wMlAxPTNzIN88US=> NVjTXIxNW0GQR1XS
NCI-H2170 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTZeGtKSzVyPUCuNFA2OzVizszN NH3vOpBUSU6JRWK=
SK-N-AS MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEC1N|Uh|ryP NWqzZXU3W0GQR1XS
NCI-H1651 MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPFcIl1UUN3ME2wMlAxPTRizszN MlLFV2FPT0WU
NCI-SNU-5 M2rYdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\pNmlEPTB;MD6wNFU1PSEQvF2= NHm4codUSU6JRWK=
SN12C NWLT[nR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fCd2lEPTB;MD6wNFU2KM7:TR?= M2PLd3NCVkeHUh?=
KY821 M4P6dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fDXmlEPTB;MD6wNFU2OSEQvF2= M1Tub3NCVkeHUh?=
SW1573 M3q4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm2PJA5UUN3ME2wMlAxPTV2IN88US=> M2fxZXNCVkeHUh?=
OE19 MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEC1OVkh|ryP M175VXNCVkeHUh?=
MPP-89 M{\6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y2WWlEPTB;MD6wNFU3PyEQvF2= MmHCV2FPT0WU
HuCCT1 M{nnWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLlblR{UUN3ME2wMlAxPTZ6IN88US=> NWfxO2lsW0GQR1XS
SW1783 NEjWeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf5SmVVUUN3ME2wMlAxPTdizszN M2raTnNCVkeHUh?=
8305C NFfSPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHyZ4ZKSzVyPUCuNFA2PzZizszN NXjEcGFSW0GQR1XS
OVCAR-4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHeyNZBKSzVyPUCuNFA2QDZizszN MU\TRW5ITVJ?
MMAC-SF MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P0R2lEPTB;MD6wNFU5PiEQvF2= NFvlblVUSU6JRWK=
COLO-824 M2qzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;oVWlKSzVyPUCuNFA2QSEQvF2= NGnmfpFUSU6JRWK=
HCC38 M2XqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DOe2lEPTB;MD6wNFYh|ryP Mn64V2FPT0WU
NCI-H1648 NHLDO2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\2NoVKSzVyPUCuNFA3ODFizszN MVnTRW5ITVJ?
NCI-H1573 M{XxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jQe2lEPTB;MD6wNFYxPyEQvF2= M4XDTHNCVkeHUh?=
MFM-223 NUDnd25oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[4SppKSzVyPUCuNFA3OTZizszN M17aUXNCVkeHUh?=
NCI-H810 NXKxNZNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M331b2lEPTB;MD6wNFYzOiEQvF2= NVS3fFN7W0GQR1XS
EM-2 M1TOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEC2NlMh|ryP MUjTRW5ITVJ?
D-283MED MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7leI5KSzVyPUCuNFA3OjRizszN MoXrV2FPT0WU
NCI-H1755 NVPUNnVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEOw[WRKSzVyPUCuNFA3OjRizszN NXTzc4RlW0GQR1XS
KYSE-70 NGTzdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vxWGlEPTB;MD6wNFYzPCEQvF2= MnHPV2FPT0WU
SW626 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rL[WlEPTB;MD6wNFYzPCEQvF2= MkntV2FPT0WU
WM-115 NUjYSGh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEC2Nlch|ryP NH3IeVJUSU6JRWK=
NB69 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrRVW1KSzVyPUCuNFA3OjlizszN NX3hSHd{W0GQR1XS
DOHH-2 NFK3Um1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPmZVJ4UUN3ME2wMlAxPjNizszN MmrRV2FPT0WU
MEL-JUSO NXHCWIVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEC2N|kh|ryP Mn34V2FPT0WU
IGR-1 NVHMcHZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XlO2lEPTB;MD6wNFY1OSEQvF2= M376OnNCVkeHUh?=
ACN M{LEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjtT49MUUN3ME2wMlAxPjR2IN88US=> MYfTRW5ITVJ?
KARPAS-45 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\WfWlEPTB;MD6wNFY2OiEQvF2= M1LV[nNCVkeHUh?=
HC-1 NW[0c2d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnPeXNjUUN3ME2wMlAxPjV4IN88US=> M{HwVnNCVkeHUh?=
MZ2-MEL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjtSFFKSzVyPUCuNFA3PThizszN M1fXVnNCVkeHUh?=
NCI-H1355 M13LSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf1TWM2OD1yLkCwOlc6KM7:TR?= M{nYfnNCVkeHUh?=
HuP-T4 M2S5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTVTWM2OD1yLkCwOlc6KM7:TR?= NF76SHBUSU6JRWK=
AsPC-1 MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEC2PFMh|ryP NVT2TJJ3W0GQR1XS
SCC-15 M4TrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzZTWM2OD1yLkCwOlg6KM7:TR?= MYnTRW5ITVJ?
CP50-MEL-B M2SwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv2TWM2OD1yLkCwOlk{KM7:TR?= Mmm2V2FPT0WU
DMS-114 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEC2PVYh|ryP MkXmV2FPT0WU
KYSE-520 NIDBPG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGq0S5lKSzVyPUCuNFA4KM7:TR?= M1zaRnNCVkeHUh?=
NCI-H2228 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[zdI1QUUN3ME2wMlAxPzJ3IN88US=> M1vpU3NCVkeHUh?=
COLO-829 NIm5XotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK5TWM2OD1yLkCwO|I2KM7:TR?= MXHTRW5ITVJ?
NCI-H2052 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnhSFczUUN3ME2wMlAxPzJ5IN88US=> M{nyfXNCVkeHUh?=
HOP-92 NEnxbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xz[mlEPTB;MD6wNFc{KM7:TR?= MULTRW5ITVJ?
MDA-MB-231 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\ZW2lEPTB;MD6wNFc{KM7:TR?= M1fme3NCVkeHUh?=
SK-MEL-30 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PzdmlEPTB;MD6wNFc{OiEQvF2= MkW5V2FPT0WU
NCI-H2087 NYj3dJZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn1TWM2OD1yLkCwO|Q5KM7:TR?= NInX[5hUSU6JRWK=
SW900 M2\zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHMcoFKSzVyPUCuNFA4PTVizszN NGPQSlBUSU6JRWK=
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ACHN NF3STIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPvVFBJUUN3ME2wMlA{PzFizszN M1HXcnNCVkeHUh?=
RH-18 NFvFcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Djb2lEPTB;MD6wN|c3OyEQvF2= NH7OOFBUSU6JRWK=
HCC2218 NH:xPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm4U2VVUUN3ME2wMlA{PzlizszN NXjWTGE3W0GQR1XS
OS-RC-2 MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37WemlEPTB;MD6wN|g3QSEQvF2= Mof4V2FPT0WU
KP-N-YN MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLVd|JKSzVyPUCuNFM5PzZizszN MUXTRW5ITVJ?
COLO-668 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjpeFA{UUN3ME2wMlA{QDh5IN88US=> NGDrXINUSU6JRWK=
LU-65 NEDnTVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\QU4pKSzVyPUCuNFM6ODRizszN MYfTRW5ITVJ?
NB6 M1:1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlO0TWM2OD1yLkCzPVUzKM7:TR?= M1TPcnNCVkeHUh?=
HT NUDYb29CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zDSmlEPTB;MD6wOFAxPyEQvF2= NH[1S2lUSU6JRWK=
COLO-684 NX;0fZBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTjNJltUUN3ME2wMlA1ODl3IN88US=> NWnjd5hvW0GQR1XS
NCI-H1693 NGHYeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\ReGlEPTB;MD6wOFMxPSEQvF2= NFXhcHBUSU6JRWK=
LAN-6 NX3kOFZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjGfXlpUUN3ME2wMlA1OzN3IN88US=> MUTTRW5ITVJ?
MDA-MB-175-VII NUnmcoFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD5TWM2OD1yLkC0OFE4KM7:TR?= NFfRVnpUSU6JRWK=
KMOE-2 NHTjbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW0Z2JpUUN3ME2wMlA1PDZ7IN88US=> MonLV2FPT0WU
DMS-79 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjJTWM2OD1yLkC0OVc6KM7:TR?= NVf4RnE4W0GQR1XS
MHH-NB-11 M2DsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorOTWM2OD1yLkC0OlE1KM7:TR?= MVnTRW5ITVJ?
NCI-H69 NVXMc5ZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm1NpdMUUN3ME2wMlA1QDR7IN88US=> NFLKXXdUSU6JRWK=
KE-37 NFHZbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEWwNUDPxE1? NYXJcXA2W0GQR1XS
Ramos-2G6-4C10 NXHLdZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPUZW5KSzVyPUCuNFUxPjdizszN MUPTRW5ITVJ?
NCI-H1793 NWjwNlhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7QTGFtUUN3ME2wMlA2ODl|IN88US=> NIjMeoVUSU6JRWK=
HT-1376 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;jTGlEPTB;MD6wOVE5PiEQvF2= MVHTRW5ITVJ?
EKVX NGixXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPjTWM2OD1yLkC1N|g1KM7:TR?= MmW2V2FPT0WU
Capan-2 NF:2eYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEizbINKSzVyPUCuNFU{QTZizszN MWTTRW5ITVJ?
DoTc2-4510 NIntdlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzpepVSUUN3ME2wMlA2PDR4IN88US=> MnzFV2FPT0WU
UACC-893 NWTKXIkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PaNGlEPTB;MD6wOVQ3OiEQvF2= NHXZXJFUSU6JRWK=
SK-MEL-3 NGHYW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG4b2hKSzVyPUCuNFU4QDhizszN NEXjNHdUSU6JRWK=
SK-MEL-1 NV\FcHNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LKUWlEPTB;MD6wOVgh|ryP M{jqT3NCVkeHUh?=
SW948 NWPhZmUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEW5PVYh|ryP NXzjUm5bW0GQR1XS
P30-OHK MoDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwME[xOlch|ryP NVP0cGlCW0GQR1XS
NH-12 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf0TWM2OD1yLkC2NlQ1KM7:TR?= MoroV2FPT0WU
KU-19-19 NX;YPVJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy4cIJKSzVyPUCuNFY{PjFizszN NFK0cYNUSU6JRWK=
A431 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHYTWM2OD1yLkC2N|c1KM7:TR?= MWXTRW5ITVJ?
NCI-H2405 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPmOnpKSzVyPUCuNFY{QDNizszN Mnr4V2FPT0WU
KARPAS-299 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXlZ4x2UUN3ME2wMlA3PTh{IN88US=> NUG0clYyW0GQR1XS
BALL-1 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XGbGlEPTB;MD6wOlY4PCEQvF2= M4Hr[nNCVkeHUh?=
KURAMOCHI MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHLSFdKSzVyPUCuNFcxPzNizszN NIjkSphUSU6JRWK=
LS-1034 NH3EPG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoWzTWM2OD1yLkC3N|Y6KM7:TR?= NUnESZpoW0GQR1XS
MFE-280 NW\BRm5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\4WlFKSzVyPUCuNFc2OzZizszN MVPTRW5ITVJ?
HOP-62 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\qdXVKSzVyPUCuNFc3PzZizszN NVHEbHo2W0GQR1XS
KG-1 MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEe3PFch|ryP NULMWJR3W0GQR1XS
CW-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXjTWM2OD1yLkC3PFMzKM7:TR?= NVP2S|hwW0GQR1XS
SW837 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnSOlJ3UUN3ME2wMlA5OzR{IN88US=> M4LqOHNCVkeHUh?=
MFH-ino NVf6VXdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS2TWM2OD1yLkC4OVAyKM7:TR?= NIfwNVdUSU6JRWK=
HCC1419 M4faVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TqSWlEPTB;MD6wPFk5PyEQvF2= NVS2eo0{W0GQR1XS
HMV-II NGX5[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEmwNUDPxE1? NXPWfGdbW0GQR1XS
BEN MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mof0TWM2OD1yLkC5N|g2KM7:TR?= MVnTRW5ITVJ?
SK-N-FI NH7Qd|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm1b4ZVUUN3ME2wMlA6PTV4IN88US=> MXLTRW5ITVJ?
JVM-2 NH\UVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7XbZhKSzVyPUCuNFk4OTZizszN M4XYbHNCVkeHUh?=
CAL-54 M2jnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfHTWM2OD1yLkGwNFQh|ryP NEDiXXdUSU6JRWK=
T84 NUDDVmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\5NWlEPTB;MD6xNFk2OiEQvF2= NYrTS|VrW0GQR1XS
SHP-77 NFqxWG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHqXoxjUUN3ME2wMlEyPjRzIN88US=> MkX2V2FPT0WU
G-361 NXXHWG4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDQWFhiUUN3ME2wMlEzOzJ2IN88US=> MkKyV2FPT0WU
Calu-3 NF\RN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nQZ2lEPTB;MD6xN|gyPiEQvF2= NFXGR5lUSU6JRWK=
HCC1937 NGfycJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMUS5N|ch|ryP MXvTRW5ITVJ?
KM-H2 MlPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS1TWM2OD1yLkG1NFEh|ryP NYjL[GZZW0GQR1XS
769-P M{nkTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvlTWM2OD1yLkG1PFQ{KM7:TR?= M3P6WHNCVkeHUh?=
NCI-H1304 NHLad29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMU[wOlEh|ryP NXvTSmtoW0GQR1XS
D-542MG MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3ETWM2OD1yLkG2Nlc5KM7:TR?= M3nmZ3NCVkeHUh?=
ATN-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV6zVHYzUUN3ME2wMlE4PDRzIN88US=> MVPTRW5ITVJ?
NCI-H2029 NI\XWJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HuTmlEPTB;MD6yNFI1OyEQvF2= MmfSV2FPT0WU
ZR-75-30 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3wTVA4UUN3ME2wMlIxPjR|IN88US=> MkTNV2FPT0WU
SW1116 NV\Tb|lST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMkGxNVch|ryP NY\aWZhXW0GQR1XS
CCRF-CEM MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLSTWM2OD1yLkK3OlE1KM7:TR?= MmnrV2FPT0WU
LU-135 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVOzToM6UUN3ME2wMlI4PzN7IN88US=> MmTnV2FPT0WU
MC116 NWHr[Y1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUOzfWYzUUN3ME2wMlI5OzB7IN88US=> NUfsTXpoW0GQR1XS
LS-513 M3Xr[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf3TWM2OD1yLkK4O|c{KM7:TR?= NGXOSmxUSU6JRWK=
NCI-H630 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMkmzO|Yh|ryP MXrTRW5ITVJ?
L-428 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMkm4PFMh|ryP MkPlV2FPT0WU
UM-UC-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT3RpFiUUN3ME2wMlMyOjlzIN88US=> MU\TRW5ITVJ?
NCI-H1838 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXPcVVRUUN3ME2wMlMyPzh2IN88US=> Mom2V2FPT0WU
HEL NXWwW3J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwM{KyOEDPxE1? NXmz[YV2W0GQR1XS
OCI-AML2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTWTWM2OD1yLkOyNlk5KM7:TR?= MVvTRW5ITVJ?
A3-KAW NXrPdmtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jxcWlEPTB;MD6zN|Q4PyEQvF2= NEPBb5lUSU6JRWK=
IGROV-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjoc2l{UUN3ME2wMlM{PzV3IN88US=> NX\uWmFtW0GQR1XS
Mo-T MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPOWGVKSzVyPUCuN|M5PTNizszN Mo\4V2FPT0WU
HDLM-2 MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\YSYpCUUN3ME2wMlM{QSEQvF2= MVLTRW5ITVJ?
HCC1569 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\XNmlEPTB;MD6zOFMxQSEQvF2= M{jzdnNCVkeHUh?=
COLO-678 NUPYOYRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\OTWM2OD1yLkO3NFAzKM7:TR?= MlP2V2FPT0WU
COR-L105 MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\qfXdjUUN3ME2wMlM4QTNizszN NG\sUm1USU6JRWK=
SK-MEL-24 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS2S2Y5UUN3ME2wMlM5Ozh{IN88US=> M33OenNCVkeHUh?=
COLO-320-HSR NYLGe45oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwNEO5O|Yh|ryP NVX0b483W0GQR1XS
C8166 NUPCepp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnKTWM2OD1yLkS5NFI{KM7:TR?= NGf3R2ZUSU6JRWK=
COLO-679 NGq0TW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HY[mlEPTB;MD62NlE4OiEQvF2= NIrWVnFUSU6JRWK=
TE-12 M3\NbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvpSnQ5UUN3ME2wMlY2Ozl2IN88US=> MYfTRW5ITVJ?
HAL-01 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PocGlEPTB;MD62OlIzKM7:TR?= NWfCdY13W0GQR1XS
H-EMC-SS M2S4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3UWGlLUUN3ME2wMlcxPTR4IN88US=> NIjZOZZUSU6JRWK=
SNU-449 NGDtWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jmeWlEPTB;MD63Nlc1QCEQvF2= MkPJV2FPT0WU
C32 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6wWVJIUUN3ME2wMlc1OTF{IN88US=> NYHIT5lFW0GQR1XS
K-562 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\BTWM2OD1yLke3NFI1KM7:TR?= NU\vSnR4W0GQR1XS
DJM-1 NV7vcFVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwN{i3PFEh|ryP MnX3V2FPT0WU
RCC10RGB NV;MU5BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfkdmtKSzVyPUCuO|kyQDNizszN NXe3R2VDW0GQR1XS
CAL-85-1 MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ae2FLUUN3ME2wMlkxPyEQvF2= NYrDVWdFW0GQR1XS
NY NULhTHNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPwTWM2OD1yLkmzN|UzKM7:TR?= MVPTRW5ITVJ?
NCI-H1993 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXzNI9UUUN3ME2xMlE6Ojh7IN88US=> MUTTRW5ITVJ?
SK-OV-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTtTnVtUUN3ME2xMlIzODh7IN88US=> MmK4V2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
体内研究 Docetaxel (33 mg/kg/dose, 静脉注射,每四天注射3次) 处理M2OL2 结肠移植瘤,结果肿瘤生长延迟19.3。Docetaxel作用于MX-1, SK-MEL-2, LX-1 和 OVCAR-3 移植瘤,也具有很强的抗肿瘤活性。Docetaxel抑制成纤维细胞生长因子2的血管反应,IC50为5.4 mg/kg,Docetaxel按10 mg/kg剂量处理小鼠,在14天期间,每周注射两次,结果血管完全堵塞。Docetaxel对内皮细胞迁移和/或微血管形成具有选择性,因为炎症细胞浸润到基底膜对Docetaxel抑制不太敏感。[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[5]
- 合并
  • Cell lines: 人类胃癌细胞系 MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 天
  • Method: 180 μL培养基中的2000个细胞接种到96孔板中,20 μL 药物溶液同时按一式三份加到每孔中。实验板在37°C下含5% CO2的培养箱中温育3天。在第3天,每孔加入25 μL MTT 试剂。温育4小时后,除去培养基。每孔加入0.2 mL DMSO,使用机械式搅拌机充分混合,溶解形成的MTT-甲臜晶体。在540 nm (OD)处测定吸光值。
    (Only for Reference)
动物实验:[6]
- 合并
  • Animal Models: 携带人类结肠癌移植瘤CX-1的小鼠
  • Formulation: 50 mg/mL储存液溶于乙醇,加入同等体积的聚山梨酯 80,然后使用 溶于水的5% 葡萄糖稀释到最终体积。
  • Dosages: 33 mg/kg
  • Administration: 静脉注射,每四天注射3次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
2mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 807.88
化学式

C43H53NO14

CAS号 114977-28-5
储存条件 粉状
溶于溶剂
别名 RP56976, NSC 628503

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04113005 Not yet recruiting Drug: Desmopressin Castrate Resistance Prostate Cancer Sunnybrook Health Sciences Centre|Sunnybrook Research Institute October 1 2019 Early Phase 1
NCT03700099 Recruiting Drug: Docetaxel|Drug: Enzalutamide Prostate Cancer|Castration-resistant Prostate Cancer Instituto do Cancer do Estado de São Paulo|Astellas Pharma Inc September 3 2019 Phase 2
NCT04067713 Recruiting -- Metastatic Prostate Cancer University College London|Epic Sciences September 20 2019 --
NCT03976375 Recruiting Biological: Pembrolizumab|Drug: Lenvatinib|Drug: Docetaxel Metastatic Non-Small Cell Lung Cancer Merck Sharp & Dohme Corp.|Eisai Inc. June 26 2019 Phase 3

技术支持

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操作手册

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID