Docetaxel (RP56976)

目录号:S1148 别名: NSC 628503 中文名称:多西他赛,多烯紫杉醇

仅限科研使用

Docetaxel (RP56976, NSC 628503)多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。

Docetaxel (RP56976) Chemical Structure

CAS: 114977-28-5

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 746.97 现货
RMB 563.39 现货
RMB 2233.96 现货
RMB 6036.03 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Docetaxel (RP56976)发表文献149篇:

产品安全说明书

Microtubule Associated抑制剂选择性比较

相关Microtubule Associated产品

生物活性

产品描述 Docetaxel (RP56976, NSC 628503)多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。
靶点
Microtubules [1]
(Cell-free assay)
体外研究

Docetaxel是一种细胞毒性剂,尤其对于增殖细胞,Docetaxel促进微管蛋白束的形成,还能诱导持续的有丝分裂阻滞,随后分裂阻滞的细胞凋亡或永久抑制分裂。 Docetaxel抑制微管的动态不稳定性及踏车现象,导致染色体不能分开到子细胞中,这样又会反过来触发有丝分裂过早结束,而不是在细胞周期的特定时期进行抑制作用。[2] Docetaxel (150 ng/mL) 处理人类小细胞肺癌 N417细胞系 1小时,抑制50% 细胞生长。 Docetaxel 处理 KB 人类表皮癌细胞, T24 人类膀胱癌细胞, Calc18 人类乳腺癌细胞, 和HCT116人类结肠腺癌96-120小时,IC50值分别为8 ng/mL, 4 ng/mL, 5 ng/mL, 和 7 ng/mL。[3] Docetaxel 处理人类癌细胞Hs746T (胃), AGS (胃), HeLa (子宫颈), CaSki (子宫颈), BxPC3 (胰腺), Capan-1 (胰腺) 24小时,抑制克隆存活,IC50 分别为 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM, 0.3 nM。[4] 通过克隆形成实验测评Docetaxel处理人类 卵巢癌细胞系 OVCA432, A2780, A2780/cp8 12天期间,IC50值分别达到0.06 nM, 0.6 nM, 和3 nM。[5]Docetaxel 作用于9种培养的人类胃癌细胞系 (MKN-7, -28, -45, NUGC-4 和KATO-III, ST-SA-1, NAKAJIMA 和ST-KM, KKLS)时,IC50 分别为 >1.2 μM, 0.6 nM, 0.1 nM, 3.5 nM, 4 nM, 99 nM, 0.3 nM,0.5 nM, 0.9 nM。[6]在体外,Docetaxel在极低浓度时,抑制内皮细胞迁移,这并不影响微管的大体形态或抑制细胞增殖,对微管动力学产生更微妙的影响。Docetaxel 抑制 HUVEC 迁移,IC50 为1 pM。Docetaxel 抑制血管生成因子胸甘磷酸化酶或血管内皮生长因子刺激的HUVEC趋化性,IC 50 为10 pM 。[7] Docetaxel (30 μM) 在添加10%人血清的培养基中温育12小时,诱导人单核细胞。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 M4DyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn1PYNKSzVyPUCuNFAxOTN{IN88US=> M171dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
5637 M1TDTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L6TGlEPTB;MD6wNFAyPDNizszN NFmxTpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
HT-144 NF:1Uo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm3eXVwUUN3ME2wMlAxODF3NzFOwG0> M{SxS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
NCI-H292 M4HH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj6N3dzUUN3ME2wMlAxODF3OTFOwG0> M2HXT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
HCE-T NUTmWnBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorUTWM2OD1yLkCwNFE3OiEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
ESS-1 M4nuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jx[2lEPTB;MD6wNFAyPzlizszN NXu3O3Y4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
D-566MG NIfsW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPO[3hNUUN3ME2wMlAxODF6MjFOwG0> NVTBdI81RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
CAL-62 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljsTWM2OD1yLkCwNFE5PSEQvF2= Mn;sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
GT3TKB NYrzVYh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLzRYtTUUN3ME2wMlAxODJ|MjFOwG0> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
HSC-4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjZXIw{UUN3ME2wMlAxODJ|OTFOwG0> NHzkcpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
KOSC-2 M3\xS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3Be4pQUUN3ME2wMlAxODJ3NTFOwG0> NGmxVYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
NB14 NWPae3pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LQOGlEPTB;MD6wNFAzPiEQvF2= MnrYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
ES8 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMECwNlYh|ryP M4rYdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
BFTC-905 M17qcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP3dXJKSzVyPUCuNFAxOjZ6IN88US=> M4\0flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
A498 Ml3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HsTmlEPTB;MD6wNFAzPzhizszN NXnRZXA3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
HO-1-N-1 NYHyPGpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP6[INXUUN3ME2wMlAxODJ6MTFOwG0> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
SF539 NULLSJg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\0VY1GUUN3ME2wMlAxODNyMjFOwG0> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
HuO-3N1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPNXoFZUUN3ME2wMlAxODNyMjFOwG0> NEPmT2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
NCI-H510A NFzQU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMECwN|M3KM7:TR?= M13HN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
CAL-27 M3;xW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMECwN|M6KM7:TR?= NVPHc5h5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
TE-8 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLWcm5GUUN3ME2wMlAxODN4NjFOwG0> NYDURnZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
VA-ES-BJ NGHKVJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMECwN|c2KM7:TR?= M{POfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
RH-1 NHLVbYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMECwN|g3KM7:TR?= M2\rbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
COLO-800 Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\0UGhkUUN3ME2wMlAxODN6ODFOwG0> M2XnZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
ES7 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P1WWlEPTB;MD6wNFA{QDlizszN NXnUT204RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
GAMG NVK0ZmpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnvbVVKSzVyPUCuNFAxPDF4IN88US=> NXTpV|FFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
Ca9-22 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HVPWlEPTB;MD6wNFA1OjNizszN M1u1fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
SBC-1 NXzxVVlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMECwOFMh|ryP MmTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
RPMI-7951 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDPTWM2OD1yLkCwNFQ1QCEQvF2= Mme2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
SW1710 M1SwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHxVlcxUUN3ME2wMlAxODR4NjFOwG0> NXnYeHdTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
HGC-27 M1\O[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMECwOFcyKM7:TR?= NGf3dGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6Oi9pPmPBUmdGWjxxYU6=
MC-IXC M3vtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkS1TWM2OD1yLkCwNFQ4QSEQvF2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
FTC-133 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\kd2lEPTB;MD6wNFA1QDlizszN MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5Nk8oRlODTlfFVlww[T5?
HT-1080 NXjIPXF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMECwOVAyKM7:TR?= M3HqblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
NMC-G1 M1O1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMECwOVE4KM7:TR?= MkjhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVIwLz6VQV7HSXI9N2F-
GI-1 MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17Pd2lEPTB;MD6wNFA2OjhizszN M1jjW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFkzNyd-U1HOS2VTRC:jPh?=
CGTH-W-1 NWnBRolCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMECwOVQzKM7:TR?= NULHcGpURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
A2058 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr3[opKSzVyPUCuNFAxPTR2IN88US=> NV3SclZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
ETK-1 NIex[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnrUmZKSzVyPUCuNFAxPTV6IN88US=> NW\hNY5bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTJxJ{7TRW5ITVJ:L3G+
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Assay
Methods Test Index PMID
Western blot PIM1 cyclin B pSTAT3 / STAT3 p-p53 / p53 18426800 22996738
Immunofluorescence α-tubulin cleaved PARP / cleaved caspase-3 Acetylated tubulin SQSTM1 / LAMP1 27177833 21087597 18426800 29795139
Growth inhibition assay Cell viability 22996738
体内研究 Docetaxel (33 mg/kg/dose, 静脉注射,每四天注射3次) 处理M2OL2 结肠移植瘤,结果肿瘤生长延迟19.3。Docetaxel作用于MX-1, SK-MEL-2, LX-1 和 OVCAR-3 移植瘤,也具有很强的抗肿瘤活性。Docetaxel抑制成纤维细胞生长因子2的血管反应,IC50为5.4 mg/kg,Docetaxel按10 mg/kg剂量处理小鼠,在14天期间,每周注射两次,结果血管完全堵塞。Docetaxel对内皮细胞迁移和/或微血管形成具有选择性,因为炎症细胞浸润到基底膜对Docetaxel抑制不太敏感。[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[5]
  • Cell lines: 人类胃癌细胞系 MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 天
  • Method: 180 μL培养基中的2000个细胞接种到96孔板中,20 μL 药物溶液同时按一式三份加到每孔中。实验板在37°C下含5% CO2的培养箱中温育3天。在第3天,每孔加入25 μL MTT 试剂。温育4小时后,除去培养基。每孔加入0.2 mL DMSO,使用机械式搅拌机充分混合,溶解形成的MTT-甲臜晶体。在540 nm (OD)处测定吸光值。
动物实验:[6]
  • Animal Models: 携带人类结肠癌移植瘤CX-1的小鼠
  • Dosages: 33 mg/kg
  • Administration: 静脉注射,每四天注射3次

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O

2mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 807.88
化学式

C43H53NO14

CAS号 114977-28-5
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05410483 Recruiting Drug: Docetaxel Hyperthermic Intraperitoneal Chemotherapy Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University March 1 2022 Phase 1
NCT05127850 Recruiting Behavioral: Consultation audio recording app Prostate Cancer|Metastatic Prostate Cancer|Metastatic Castration-resistant Prostate Cancer University of California San Francisco|Conquer Cancer Foundation March 22 2022 Not Applicable
NCT05094336 Recruiting Drug: AMG 193|Drug: Docetaxel Advanced MTAP-null Solid Tumors Amgen February 1 2022 Phase 1|Phase 2
NCT05027204 Recruiting Drug: Docetaxel|Drug: Nivolumab Squamous Cell Carcinoma of Head and Neck CSPC ZhongQi Pharmaceutical Technology Co. Ltd. February 2022 Phase 1|Phase 2
NCT05114915 Recruiting Drug: Albumin-bound docetaxel Advanced Solid Tumors CSPC ZhongQi Pharmaceutical Technology Co. Ltd. January 7 2022 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技术支持

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