Docetaxel

For research use only. Not for use in humans.

目录号:S1148 别名: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 746.97 现货
RMB 563.39 现货
RMB 2233.96 现货
RMB 4013.1 现货
RMB 6036.03 现货
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全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Docetaxel发表文献75篇:

产品安全说明书

Microtubule Associated抑制剂选择性比较

生物活性

产品描述 Docetaxel多西他赛一种taxol类似物,是一种microtubules解聚抑制剂,通过结合于稳定的微管发挥作用。
靶点
Microtubules [1]
(Cell-free assay)
体外研究

Docetaxel是一种细胞毒性剂,尤其对于增殖细胞,Docetaxel促进微管蛋白束的形成,还能诱导持续的有丝分裂阻滞,随后分裂阻滞的细胞凋亡或永久抑制分裂。 Docetaxel抑制微管的动态不稳定性及踏车现象,导致染色体不能分开到子细胞中,这样又会反过来触发有丝分裂过早结束,而不是在细胞周期的特定时期进行抑制作用。[2] Docetaxel (150 ng/mL) 处理人类小细胞肺癌 N417细胞系 1小时,抑制50% 细胞生长。 Docetaxel 处理 KB 人类表皮癌细胞, T24 人类膀胱癌细胞, Calc18 人类乳腺癌细胞, 和HCT116人类结肠腺癌96-120小时,IC50值分别为8 ng/mL, 4 ng/mL, 5 ng/mL, 和 7 ng/mL。[3] Docetaxel 处理人类癌细胞Hs746T (胃), AGS (胃), HeLa (子宫颈), CaSki (子宫颈), BxPC3 (胰腺), Capan-1 (胰腺) 24小时,抑制克隆存活,IC50 分别为 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM, 0.3 nM。[4] 通过克隆形成实验测评Docetaxel处理人类 卵巢癌细胞系 OVCA432, A2780, A2780/cp8 12天期间,IC50值分别达到0.06 nM, 0.6 nM, 和3 nM。[5]Docetaxel 作用于9种培养的人类胃癌细胞系 (MKN-7, -28, -45, NUGC-4 和KATO-III, ST-SA-1, NAKAJIMA 和ST-KM, KKLS)时,IC50 分别为 >1.2 μM, 0.6 nM, 0.1 nM, 3.5 nM, 4 nM, 99 nM, 0.3 nM,0.5 nM, 0.9 nM。[6]在体外,Docetaxel在极低浓度时,抑制内皮细胞迁移,这并不影响微管的大体形态或抑制细胞增殖,对微管动力学产生更微妙的影响。Docetaxel 抑制 HUVEC 迁移,IC50 为1 pM。Docetaxel 抑制血管生成因子胸甘磷酸化酶或血管内皮生长因子刺激的HUVEC趋化性,IC 50 为10 pM 。[7] Docetaxel (30 μM) 在添加10%人血清的培养基中温育12小时,诱导人单核细胞。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37SVmlEPTB;MD6wNFAyOzJizszN M2XHZXNCVkeHUh?=
5637 M{TjTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vPNGlEPTB;MD6wNFAyPDNizszN M4TXPXNCVkeHUh?=
HT-144 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPwNYtvUUN3ME2wMlAxODF3NzFOwG0> MojCV2FPT0WU
NCI-H292 NGjOfGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[4WnNzUUN3ME2wMlAxODF3OTFOwG0> MUXTRW5ITVJ?
HCE-T MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CxWGlEPTB;MD6wNFAyPjJizszN M3rzcXNCVkeHUh?=
ESS-1 Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnZS|RKSzVyPUCuNFAxOTd7IN88US=> Mnj5V2FPT0WU
D-566MG M{Pu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPFcW1KSzVyPUCuNFAxOTh{IN88US=> NXXXflR[W0GQR1XS
CAL-62 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\xTWM2OD1yLkCwNFE5PSEQvF2= NY\1SIpNW0GQR1XS
GT3TKB MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILYW21KSzVyPUCuNFAxOjN{IN88US=> MUDTRW5ITVJ?
HSC-4 NVHBNlRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMECwNlM6KM7:TR?= MmS1V2FPT0WU
KOSC-2 MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH2TWM2OD1yLkCwNFI2PSEQvF2= M3TuUXNCVkeHUh?=
NB14 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\JTWM2OD1yLkCwNFI3KM7:TR?= MVXTRW5ITVJ?
ES8 M3qxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nPdWlEPTB;MD6wNFAzPiEQvF2= MUPTRW5ITVJ?
BFTC-905 NV35ZodKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMECwNlY5KM7:TR?= NFG2RZpUSU6JRWK=
A498 NG\WeXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;aW2lEPTB;MD6wNFAzPzhizszN MofuV2FPT0WU
HO-1-N-1 MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f2eGlEPTB;MD6wNFAzQDFizszN NHvydmZUSU6JRWK=
SF539 M2PocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPnUoxKSzVyPUCuNFAxOzB{IN88US=> MVnTRW5ITVJ?
HuO-3N1 NWHLXoNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DjWmlEPTB;MD6wNFA{ODJizszN NY[4WHQzW0GQR1XS
NCI-H510A MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMECwN|M3KM7:TR?= MnXNV2FPT0WU
CAL-27 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrnNYxNUUN3ME2wMlAxODN|OTFOwG0> MYHTRW5ITVJ?
TE-8 M3\XcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDhTWM2OD1yLkCwNFM3PiEQvF2= M{TIO3NCVkeHUh?=
VA-ES-BJ MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\XU48zUUN3ME2wMlAxODN5NTFOwG0> MoGyV2FPT0WU
RH-1 M{LlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMECwN|g3KM7:TR?= NEDKUGhUSU6JRWK=
COLO-800 NXjxZ4N{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMECwN|g5KM7:TR?= NFvucZpUSU6JRWK=
ES7 M2LJfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfY[|dKSzVyPUCuNFAxOzh7IN88US=> NY\ud4xHW0GQR1XS
GAMG NIDlV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojKTWM2OD1yLkCwNFQyPiEQvF2= M2rNWHNCVkeHUh?=
Ca9-22 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMECwOFI{KM7:TR?= M{DrOHNCVkeHUh?=
SBC-1 NVX3ZXE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMECwOFMh|ryP MY\TRW5ITVJ?
RPMI-7951 NYnm[ZZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;LeJNmUUN3ME2wMlAxODR2ODFOwG0> NHLj[HFUSU6JRWK=
SW1710 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\G[WlEPTB;MD6wNFA1PjZizszN Mo\nV2FPT0WU
HGC-27 Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HmSmlEPTB;MD6wNFA1PzFizszN MV7TRW5ITVJ?
MC-IXC MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K1ZmlEPTB;MD6wNFA1PzlizszN M3nQZnNCVkeHUh?=
FTC-133 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjSeW1KSzVyPUCuNFAxPDh7IN88US=> M1S3eXNCVkeHUh?=
HT-1080 M2rRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn25TWM2OD1yLkCwNFUxOSEQvF2= NYHNZ5dNW0GQR1XS
NMC-G1 NULERpN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi2UJJUUUN3ME2wMlAxODVzNzFOwG0> MlrpV2FPT0WU
GI-1 M3TXNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGxOZRnUUN3ME2wMlAxODV{ODFOwG0> NHvKSFhUSU6JRWK=
CGTH-W-1 M3\sfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMECwOVQzKM7:TR?= NIOxU3hUSU6JRWK=
A2058 NGn3OpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XreGlEPTB;MD6wNFA2PDRizszN MYXTRW5ITVJ?
ETK-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\wcZBuUUN3ME2wMlAxODV3ODFOwG0> MmXtV2FPT0WU
NEC8 NHfXWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHoPIFkUUN3ME2wMlAxODV4MTFOwG0> M4H6d3NCVkeHUh?=
TE-11 M4n5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPmXXJQUUN3ME2wMlAxODV4OTFOwG0> NI\4O4lUSU6JRWK=
NCI-H720 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMECwOVgh|ryP NIOwT5NUSU6JRWK=
PSN1 M3jhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7GTWM2OD1yLkCwNFU5OSEQvF2= MnXMV2FPT0WU
SW780 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPVTWM2OD1yLkCwNFU5PyEQvF2= MUjTRW5ITVJ?
8-MG-BA MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfzXZVKSzVyPUCuNFAxPTh7IN88US=> MoXEV2FPT0WU
EC-GI-10 NH7EfG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\vTWM2OD1yLkCwNFU6OiEQvF2= MV\TRW5ITVJ?
SJSA-1 NHfTWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrNfVdWUUN3ME2wMlAxODZzNTFOwG0> NWHSdHRjW0GQR1XS
639-V MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4KwT2lEPTB;MD6wNFA3PDdizszN Mk\YV2FPT0WU
PFSK-1 NI\jWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq5Z5VKSzVyPUCuNFAxPjV5IN88US=> Mk\ZV2FPT0WU
DMS-273 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PrNWlEPTB;MD6wNFA3PzRizszN NYTGfnR{W0GQR1XS
TE-9 M1jwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fMU2lEPTB;MD6wNFA3PzZizszN NVfrcYNqW0GQR1XS
SCC-25 NWPsTXpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvZTWM2OD1yLkCwNFY5KM7:TR?= Mkn1V2FPT0WU
PA-1 NGPT[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHKSJI2UUN3ME2wMlAxODZ6NzFOwG0> MVLTRW5ITVJ?
MHH-ES-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfLe5k6UUN3ME2wMlAxODdizszN NIPSPJNUSU6JRWK=
Daoy M{TuSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW2XXBKSzVyPUCuNFAxPyEQvF2= M2XMbHNCVkeHUh?=
G-402 M4rPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvHTWM2OD1yLkCwNFcxPiEQvF2= M3LVbXNCVkeHUh?=
YKG-1 NXvJRXpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPoUI9KSzVyPUCuNFAxPzB5IN88US=> M37HXHNCVkeHUh?=
Ca-Ski M2DTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMECwO|I5KM7:TR?= NGHPPYNUSU6JRWK=
CHP-212 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Hh[GlEPTB;MD6wNFA4OyEQvF2= M1TyO3NCVkeHUh?=
SCC-4 NWHkWFZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3TNndKSzVyPUCuNFAxPzN7IN88US=> NIe2d|hUSU6JRWK=
EW-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGezWHpKSzVyPUCuNFAxPzR3IN88US=> M3HYVnNCVkeHUh?=
P12-ICHIKAWA NU\2ZYNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PrS2lEPTB;MD6wNFA4PDVizszN M37ZPHNCVkeHUh?=
HSC-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDkVYpKSzVyPUCuNFAxPzV3IN88US=> NGHJW49USU6JRWK=
HN NVK0d5h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfyW2tFUUN3ME2wMlAxODd3ODFOwG0> MoHYV2FPT0WU
LXF-289 MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTSTWM2OD1yLkCwNFc2QCEQvF2= NFX2cGhUSU6JRWK=
ES1 M1rrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XTRWlEPTB;MD6wNFA4PyEQvF2= NXnMUnF2W0GQR1XS
NTERA-S-cl-D1 MlG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjFXY9KSzVyPUCuNFAxPzd|IN88US=> NHLOOoFUSU6JRWK=
K5 Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnLTWM2OD1yLkCwNFc4QCEQvF2= MnjCV2FPT0WU
HOS NX31NVc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH3fYN[UUN3ME2wMlAxODd6MjFOwG0> NVfpcVM5W0GQR1XS
YH-13 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMECwO|kyKM7:TR?= NInMUGtUSU6JRWK=
SW954 M1zlemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPDTWM2OD1yLkCwNFgzOyEQvF2= NGHSXHpUSU6JRWK=
KYSE-510 NXjyNIdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jkZmlEPTB;MD6wNFA5PCEQvF2= MnHXV2FPT0WU
8505C MoLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HWOGlEPTB;MD6wNFA5PTRizszN MoXIV2FPT0WU
A549 NHXNeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPuTWM2OD1yLkCwNFg5OiEQvF2= NX;rVHE3W0GQR1XS
Detroit562 NIHkcZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHtZYpKSzVyPUCuNFAxQTB{IN88US=> MkC2V2FPT0WU
ES5 M{D5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2K2VGlEPTB;MD6wNFA6OSEQvF2= NEPlV3dUSU6JRWK=
KYSE-140 NX;2ZnhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMECwPVM{KM7:TR?= NXyyZW8xW0GQR1XS
GMS-10 MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjsRmFHUUN3ME2wMlAxODl2MTFOwG0> MULTRW5ITVJ?
D-263MG M2TKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17yVGlEPTB;MD6wNFA6PDdizszN Mly2V2FPT0WU
BCPAP MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TV[WlEPTB;MD6wNFA6PDdizszN M2DQ[HNCVkeHUh?=
CHL-1 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHSc2xvUUN3ME2wMlAxODl3ODFOwG0> Mn3iV2FPT0WU
RKO MlzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMECwPVg6KM7:TR?= NUe4WohKW0GQR1XS
SW48 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILuSZRKSzVyPUCuNFAyODFizszN Mm\jV2FPT0WU
BPH-1 NGPRUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMECxNFIh|ryP NVjLSYkzW0GQR1XS
EFO-27 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLnTWM2OD1yLkCwNVAzKM7:TR?= M13PfXNCVkeHUh?=
CAL-33 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMECxNFQh|ryP M{nlfXNCVkeHUh?=
NCI-H1792 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMECxNFQh|ryP NYHlXlJRW0GQR1XS
BB30-HNC NUjpcXFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrMTWM2OD1yLkCwNVA2KM7:TR?= NGr6cphUSU6JRWK=
VM-CUB-1 NVjvXFdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMECxNFUh|ryP NEjsRphUSU6JRWK=
TE-5 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjsRo5rUUN3ME2wMlAxOTB4IN88US=> Mn\IV2FPT0WU
NB13 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4GxTWlEPTB;MD6wNFExPyEQvF2= Mlr4V2FPT0WU
NBsusSR Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7H[4VKSzVyPUCuNFAyOSEQvF2= NXO1NVdMW0GQR1XS
LNCaP-Clone-FGC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\nTWM2OD1yLkCwNVEh|ryP MWfTRW5ITVJ?
EPLC-272H M{fETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMECxNVEh|ryP MV3TRW5ITVJ?
KNS-62 M{fjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1niUmlEPTB;MD6wNFEyOiEQvF2= NGXHWHpUSU6JRWK=
RERF-LC-MS NFjnblBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnJelVKSzVyPUCuNFAyOTNizszN MYjTRW5ITVJ?
LOXIMVI MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3Ie2FKSzVyPUCuNFAyOTZizszN M16yOXNCVkeHUh?=
KINGS-1 MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X1WWlEPTB;MD6wNFEyPyEQvF2= Mnv6V2FPT0WU
T98G NYLmRnpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHmTWM2OD1yLkCwNVE4KM7:TR?= M{DLU3NCVkeHUh?=
HCC1806 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTnTWM2OD1yLkCwNVE5KM7:TR?= NX\QUlQxW0GQR1XS
MZ1-PC Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlKzTWM2OD1yLkCwNVE5KM7:TR?= MkXrV2FPT0WU
RT-112 NVLKR|cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMECxNVkh|ryP MnLmV2FPT0WU
LK-2 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrUN3VKSzVyPUCuNFAyOjFizszN MWDTRW5ITVJ?
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BB65-RCC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X4bWlEPTB;MD6wNFMxQCEQvF2= MkezV2FPT0WU
NUGC-3 M1mzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LwTGlEPTB;MD6wNFMxQCEQvF2= MoTqV2FPT0WU
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NCI-H23 NFG1WlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLpUGNGUUN3ME2wMlAxOzZ2IN88US=> MV\TRW5ITVJ?
NCI-H226 NF7SdpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvBVlRDUUN3ME2wMlAxOzZ6IN88US=> MU\TRW5ITVJ?
NCI-H520 NF7WbGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jOWGlEPTB;MD6wNFM4OiEQvF2= NGfOPWFUSU6JRWK=
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CAL-12T Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLjPFlFUUN3ME2wMlAxOzd4IN88US=> M3jPVXNCVkeHUh?=
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OCUB-M Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLnTWM2OD1yLkCwOFM5KM7:TR?= NX\1dHhRW0GQR1XS
Calu-6 M33jOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEC0OFch|ryP MVfTRW5ITVJ?
MDA-MB-453 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjUe4pxUUN3ME2wMlAxPDVzIN88US=> M37nS3NCVkeHUh?=
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RVH-421 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDrRYlKSzVyPUCuNFA1PjFizszN MoXCV2FPT0WU
TGBC11TKB Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH0SZNLUUN3ME2wMlAxPDZ7IN88US=> NIXoPHpUSU6JRWK=
MOLT-4 NGPlTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\nWGlEPTB;MD6wNFQ4OSEQvF2= NVL1[G85W0GQR1XS
LN-405 NHvmR3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEC0PFIh|ryP NUnUZ|dEW0GQR1XS
S-117 NInjT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDWTWM2OD1yLkCwOFg3KM7:TR?= MYHTRW5ITVJ?
RPMI-8226 NXn2VYpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH5dFBZUUN3ME2wMlAxPDl5IN88US=> NF7pSmdUSU6JRWK=
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NCI-H1666 NIq2RWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVftc|Z7UUN3ME2wMlAxPTB3IN88US=> NVnMPZRDW0GQR1XS
Mewo MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3rd|d5UUN3ME2wMlAxPTB3IN88US=> MUHTRW5ITVJ?
AN3-CA NHHDWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\nPWlEPTB;MD6wNFUxPyEQvF2= MVXTRW5ITVJ?
COLO-680N MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHyTWM2OD1yLkCwOVA5KM7:TR?= MWfTRW5ITVJ?
FADU MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17CT2lEPTB;MD6wNFUyKM7:TR?= NE\SUGdUSU6JRWK=
GB-1 NH3LcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjHbVNKSzVyPUCuNFA2OTFizszN MUfTRW5ITVJ?
KASUMI-1 M1S2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHxTWM2OD1yLkCwOVEyKM7:TR?= MoXLV2FPT0WU
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NCI-H2170 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHITWM2OD1yLkCwOVM2KM7:TR?= MULTRW5ITVJ?
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NCI-H1651 M3TNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEC1OEDPxE1? MlvzV2FPT0WU
NCI-SNU-5 M4DB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEC1OFUh|ryP NHLQe|VUSU6JRWK=
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KY821 MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLvcW9uUUN3ME2wMlAxPTVzIN88US=> Ml\ZV2FPT0WU
SW1573 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEC1OVQh|ryP MWrTRW5ITVJ?
OE19 M4fXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHCN2lmUUN3ME2wMlAxPTV7IN88US=> MWrTRW5ITVJ?
MPP-89 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jUZ2lEPTB;MD6wNFU3PyEQvF2= NWm0WHEzW0GQR1XS
HuCCT1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD6[WVrUUN3ME2wMlAxPTZ6IN88US=> M1vDWnNCVkeHUh?=
SW1783 Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ftO2lEPTB;MD6wNFU4KM7:TR?= MWrTRW5ITVJ?
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OVCAR-4 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m3TWlEPTB;MD6wNFU5PiEQvF2= MoDDV2FPT0WU
MMAC-SF MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X2S2lEPTB;MD6wNFU5PiEQvF2= MV3TRW5ITVJ?
COLO-824 NXXj[oRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L4[GlEPTB;MD6wNFU6KM7:TR?= NED4dm5USU6JRWK=
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NCI-H1648 Mn3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEC2NFEh|ryP NEjGOHdUSU6JRWK=
NCI-H1573 M4PLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\BTWM2OD1yLkCwOlA4KM7:TR?= MVrTRW5ITVJ?
MFM-223 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfocFNIUUN3ME2wMlAxPjF4IN88US=> NITsPGZUSU6JRWK=
NCI-H810 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEC2NlIh|ryP M2DCbXNCVkeHUh?=
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NCI-H1755 NXyycIRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPHT5c2UUN3ME2wMlAxPjJ2IN88US=> NWfRbm9oW0GQR1XS
KYSE-70 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjZTWM2OD1yLkCwOlI1KM7:TR?= MorHV2FPT0WU
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HC-1 Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2noVWlEPTB;MD6wNFY2PiEQvF2= NX\WOpFXW0GQR1XS
MZ2-MEL NETOS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS5d3JKSzVyPUCuNFA3PThizszN MWrTRW5ITVJ?
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DMS-114 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEC2PVYh|ryP NV7VZpBTW0GQR1XS
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NCI-H2228 NWP6RXM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEC3NlUh|ryP NFTjcYRUSU6JRWK=
COLO-829 NUXYSWJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEC3NlUh|ryP NWSxdpQ1W0GQR1XS
NCI-H2052 M3vTcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[5TGVWUUN3ME2wMlAxPzJ5IN88US=> NEXNemFUSU6JRWK=
HOP-92 NYewe|hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jwU2lEPTB;MD6wNFc{KM7:TR?= MULTRW5ITVJ?
MDA-MB-231 NH;TXVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTle257UUN3ME2wMlAxPzNizszN NInqOIZUSU6JRWK=
SK-MEL-30 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXHTHpZUUN3ME2wMlAxPzN{IN88US=> NIrnRXlUSU6JRWK=
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NCI-H2342 M2XPfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID2WldKSzVyPUCuNFM3OzNizszN M4PHVnNCVkeHUh?=
ACHN MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;JTWM2OD1yLkCzO|Eh|ryP Mn3BV2FPT0WU
RH-18 NHG1c2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjGXW9KSzVyPUCuNFM4PjNizszN MVLTRW5ITVJ?
HCC2218 M1fSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjiUo5KSzVyPUCuNFM4QSEQvF2= NGnpcZZUSU6JRWK=
OS-RC-2 M4jM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XCNmlEPTB;MD6wN|g3QSEQvF2= NHLpOmZUSU6JRWK=
KP-N-YN NU[yT4Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvIfXFiUUN3ME2wMlA{QDd4IN88US=> NV\ldJZ4W0GQR1XS
COLO-668 NV7IS29YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jCcmlEPTB;MD6wN|g5PyEQvF2= MVfTRW5ITVJ?
LU-65 M2LTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvxbHFKSzVyPUCuNFM6ODRizszN M1TKT3NCVkeHUh?=
NB6 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fKU2lEPTB;MD6wN|k2OiEQvF2= M2rOWXNCVkeHUh?=
HT MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnBTWM2OD1yLkC0NFA4KM7:TR?= NYOwfJhOW0GQR1XS
COLO-684 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL0TWM2OD1yLkC0NFk2KM7:TR?= MVzTRW5ITVJ?
NCI-H1693 NITjcpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnlcWtKSzVyPUCuNFQ{ODVizszN Mln1V2FPT0WU
LAN-6 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDl[JhKSzVyPUCuNFQ{OzVizszN NUP0NHhCW0GQR1XS
MDA-MB-175-VII M2e2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCzTWM2OD1yLkC0OFE4KM7:TR?= NIX1ZnRUSU6JRWK=
KMOE-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzQTWM2OD1yLkC0OFY6KM7:TR?= NIPB[ZFUSU6JRWK=
DMS-79 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjNTWM2OD1yLkC0OVc6KM7:TR?= M1rGW3NCVkeHUh?=
MHH-NB-11 NVnEO4pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLOO5NEUUN3ME2wMlA1PjF2IN88US=> NE\4V|lUSU6JRWK=
NCI-H69 M1roeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;odWlEPTB;MD6wOFg1QSEQvF2= NWC1N|E3W0GQR1XS
KE-37 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;oTWM2OD1yLkC1NFEh|ryP NHnjWmtUSU6JRWK=
Ramos-2G6-4C10 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEWwOlch|ryP M4PWWHNCVkeHUh?=
NCI-H1793 NH\oN|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITOSIVKSzVyPUCuNFUxQTNizszN NWXSXnF4W0GQR1XS
HT-1376 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHEd|VKSzVyPUCuNFUyQDZizszN MXTTRW5ITVJ?
EKVX MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITKd5JKSzVyPUCuNFU{QDRizszN MnvFV2FPT0WU
Capan-2 NGexTZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEWzPVYh|ryP NFzBcnpUSU6JRWK=
DoTc2-4510 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HYTWlEPTB;MD6wOVQ1PiEQvF2= M2q2U3NCVkeHUh?=
UACC-893 NHrjV4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\tVIRKSzVyPUCuNFU1PjJizszN MYDTRW5ITVJ?
SK-MEL-3 NGnTOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEW3PFgh|ryP NHHC[oZUSU6JRWK=
SK-MEL-1 NI\Ib2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX61d3Y5UUN3ME2wMlA2QCEQvF2= NF74PIRUSU6JRWK=
SW948 Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrJWItSUUN3ME2wMlA2QTl4IN88US=> NXHqRmJQW0GQR1XS
P30-OHK NYPLdoJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUOwdoI6UUN3ME2wMlA3OTZ5IN88US=> M3LEZnNCVkeHUh?=
NH-12 M{Kydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ezPGlEPTB;MD6wOlI1PCEQvF2= MlzHV2FPT0WU
KU-19-19 NHjUeJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwME[zOlEh|ryP NEnxTYNUSU6JRWK=
A431 M1zMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\NTWM2OD1yLkC2N|c1KM7:TR?= NX3DcHlyW0GQR1XS
NCI-H2405 NHr4bnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPzTWM2OD1yLkC2N|g{KM7:TR?= M17xTXNCVkeHUh?=
KARPAS-299 NX;6RlFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:1cWlEPTB;MD6wOlU5OiEQvF2= MXfTRW5ITVJ?
BALL-1 NYHUSlhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi5TWVlUUN3ME2wMlA3Pjd2IN88US=> MkDzV2FPT0WU
KURAMOCHI M3i5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOyVlZqUUN3ME2wMlA4ODd|IN88US=> MWLTRW5ITVJ?
LS-1034 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zVUWlEPTB;MD6wO|M3QSEQvF2= MV;TRW5ITVJ?
MFE-280 MonXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\iSlNZUUN3ME2wMlA4PTN4IN88US=> NHL3SI1USU6JRWK=
HOP-62 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEe2O|Yh|ryP MYfTRW5ITVJ?
KG-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT2SWdvUUN3ME2wMlA4Pzh5IN88US=> NH\LRopUSU6JRWK=
CW-2 MnHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnyUYJKSzVyPUCuNFc5OzJizszN M4jq[3NCVkeHUh?=
SW837 M1TPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XyZWlEPTB;MD6wPFM1OiEQvF2= NH7MOJFUSU6JRWK=
MFH-ino NIHoW|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEi1NFEh|ryP MlHIV2FPT0WU
HCC1419 NXTJTlRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqzR3hKSzVyPUCuNFg6QDdizszN MX3TRW5ITVJ?
HMV-II MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XnSmlEPTB;MD6wPVAyKM7:TR?= MmX0V2FPT0WU
BEN MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjQTWM2OD1yLkC5N|g2KM7:TR?= M2\1e3NCVkeHUh?=
SK-N-FI MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS0eo5KSzVyPUCuNFk2PTZizszN M3TJb3NCVkeHUh?=
JVM-2 NILsWXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEm3NVYh|ryP Mn:5V2FPT0WU
CAL-54 MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHVPGQ2UUN3ME2wMlExODRizszN Ml3WV2FPT0WU
T84 M3vPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET3XlJKSzVyPUCuNVA6PTJizszN M3vpN3NCVkeHUh?=
SHP-77 NV\CUVluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMUG2OFEh|ryP Mn7PV2FPT0WU
G-361 NV7mO|BDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMUKzNlQh|ryP NHHUSWhUSU6JRWK=
Calu-3 NXXLV|VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzJ[4lKSzVyPUCuNVM5OTZizszN Mn3lV2FPT0WU
HCC1937 NF\wbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmexTWM2OD1yLkG0PVM4KM7:TR?= NUjqWmM1W0GQR1XS
KM-H2 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3KZ|RKSzVyPUCuNVUxOSEQvF2= Mnr5V2FPT0WU
769-P NGDtNY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMUW4OFMh|ryP MYDTRW5ITVJ?
NCI-H1304 M4\yeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37PbmlEPTB;MD6xOlA3OSEQvF2= MofwV2FPT0WU
D-542MG M{Ljcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfKbmpKSzVyPUCuNVYzPzhizszN MYHTRW5ITVJ?
ATN-1 MnTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPxWpY2UUN3ME2wMlE4PDRzIN88US=> NELvenhUSU6JRWK=
NCI-H2029 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHBTWM2OD1yLkKwNlQ{KM7:TR?= MV7TRW5ITVJ?
ZR-75-30 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTvTWM2OD1yLkKwOlQ{KM7:TR?= M3yy[XNCVkeHUh?=
SW1116 NIfteGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3pcmpKSzVyPUCuNlEyOTdizszN Mni5V2FPT0WU
CCRF-CEM MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz3WW14UUN3ME2wMlI4PjF2IN88US=> MWDTRW5ITVJ?
LU-135 NU\Tc2FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMke3N|kh|ryP MmPXV2FPT0WU
MC116 NEWzUHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrw[HVKSzVyPUCuNlg{ODlizszN M1zXSnNCVkeHUh?=
LS-513 NYnSWYY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\2WFZlUUN3ME2wMlI5Pzd|IN88US=> NV76RoozW0GQR1XS
NCI-H630 NVrqOHA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S5XGlEPTB;MD6yPVM4PiEQvF2= Mn\wV2FPT0WU
L-428 NUXQXpdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMkm4PFMh|ryP MkPkV2FPT0WU
UM-UC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwM{GyPVEh|ryP NEXKXWxUSU6JRWK=
NCI-H1838 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPwZ5hrUUN3ME2wMlMyPzh2IN88US=> Mn;EV2FPT0WU
HEL MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwM{KyOEDPxE1? NGiydYpUSU6JRWK=
OCI-AML2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwM{KyPVgh|ryP Ml\qV2FPT0WU
A3-KAW MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlezTWM2OD1yLkOzOFc4KM7:TR?= M3nJbnNCVkeHUh?=
IGROV-1 M3nldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrXeZlKSzVyPUCuN|M4PTVizszN MYHTRW5ITVJ?
Mo-T NYjSbVF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW3TWM2OD1yLkOzPFU{KM7:TR?= MXnTRW5ITVJ?
HDLM-2 NVLHWHlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf6ZpBQUUN3ME2wMlM{QSEQvF2= NXTjRoRIW0GQR1XS
HCC1569 M1zVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDCW214UUN3ME2wMlM1OzB7IN88US=> NIfaS|dUSU6JRWK=
COLO-678 NXTD[VFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m2OGlEPTB;MD6zO|AxOiEQvF2= M3fZZ3NCVkeHUh?=
COR-L105 M{Ltdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvWTWM2OD1yLkO3PVMh|ryP MYPTRW5ITVJ?
SK-MEL-24 M2DPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nDU2lEPTB;MD6zPFM5OiEQvF2= MlrwV2FPT0WU
COLO-320-HSR Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDpcGhKSzVyPUCuOFM6PzZizszN NXzZUY11W0GQR1XS
C8166 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi0UmRKSzVyPUCuOFkxOjNizszN NUL1eXV2W0GQR1XS
COLO-679 M3HMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GwOmlEPTB;MD62NlE4OiEQvF2= NWPFXnRzW0GQR1XS
TE-12 MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jOXGlEPTB;MD62OVM6PCEQvF2= M2\0[3NCVkeHUh?=
HAL-01 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHtVIw4UUN3ME2wMlY3OjJizszN MYDTRW5ITVJ?
H-EMC-SS MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHCNnhKSzVyPUCuO|A2PDZizszN NYrJW2FnW0GQR1XS
SNU-449 NVTVWJQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwN{K3OFgh|ryP NWe3b2wyW0GQR1XS
C32 M17sW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnIR2VFUUN3ME2wMlc1OTF{IN88US=> MULTRW5ITVJ?
K-562 M3v2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P1dGlEPTB;MD63O|AzPCEQvF2= M2naUnNCVkeHUh?=
DJM-1 NVLCbJVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWwUmlKSzVyPUCuO|g4QDFizszN MoHyV2FPT0WU
RCC10RGB NV;ZUnNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP1fYZWUUN3ME2wMlc6OTh|IN88US=> NVzSOXlrW0GQR1XS
CAL-85-1 M2[2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfoc5pKSzVyPUCuPVA4KM7:TR?= NYPWWmtsW0GQR1XS
NY NYj0fVhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\oe|FKSzVyPUCuPVM{PTJizszN NHnQU4VUSU6JRWK=
NCI-H1993 M3qzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfZ[llkUUN3ME2xMlE6Ojh7IN88US=> MYXTRW5ITVJ?
SK-OV-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PUXWlEPTB;MT6yNlA5QSEQvF2= Mnf6V2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
体内研究 Docetaxel (33 mg/kg/dose, 静脉注射,每四天注射3次) 处理M2OL2 结肠移植瘤,结果肿瘤生长延迟19.3。Docetaxel作用于MX-1, SK-MEL-2, LX-1 和 OVCAR-3 移植瘤,也具有很强的抗肿瘤活性。Docetaxel抑制成纤维细胞生长因子2的血管反应,IC50为5.4 mg/kg,Docetaxel按10 mg/kg剂量处理小鼠,在14天期间,每周注射两次,结果血管完全堵塞。Docetaxel对内皮细胞迁移和/或微血管形成具有选择性,因为炎症细胞浸润到基底膜对Docetaxel抑制不太敏感。[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[5]
- 合并
  • Cell lines: 人类胃癌细胞系 MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 天
  • Method: 180 μL培养基中的2000个细胞接种到96孔板中,20 μL 药物溶液同时按一式三份加到每孔中。实验板在37°C下含5% CO2的培养箱中温育3天。在第3天,每孔加入25 μL MTT 试剂。温育4小时后,除去培养基。每孔加入0.2 mL DMSO,使用机械式搅拌机充分混合,溶解形成的MTT-甲臜晶体。在540 nm (OD)处测定吸光值。
    (Only for Reference)
动物实验:[6]
- 合并
  • Animal Models: 携带人类结肠癌移植瘤CX-1的小鼠
  • Dosages: 33 mg/kg
  • Administration: 静脉注射,每四天注射3次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Water Insoluble
Ethanol '53 mg/mL warmed
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
2mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 807.88
化学式

C43H53NO14

CAS号 114977-28-5
储存条件 粉状
溶于溶剂
别名 RP56976, NSC 628503

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04364620 Not yet recruiting Drug: AB-16B5|Drug: Docetaxel NSCLC Stage IV Alethia Biotherapeutics August 2020 Phase 2
NCT04343885 Recruiting Drug: 177Lu-PSMA-617|Drug: Docetaxel Metastatic Hormone Naive Prostate Cancer Peter MacCallum Cancer Centre Australia|Movember Foundation|Prostate Cancer Research Alliance|United States Department of Defense|Advanced Accelerator Applications|Australian Nuclear Science and Technology Organisation (ANSTO)|Australian and New Zealand Urogenital and Prostate Cancer Trials Group|Australasian Radiopharmaceutical Trials network (ARTnet)|Centre for Biostatistics and Clinical Trials (BaCT) April 21 2020 Phase 2
NCT04256707 Recruiting Drug: Selinexor|Drug: Docetaxel|Drug: Pembrolizumab Non-Small Cell Lung Carcinoma (NSCLC)|Colorectal Cancer (CRC) Karyopharm Therapeutics Inc January 14 2020 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID