Docetaxel
别名: NSC 628503,RP56976 中文名称：多西他赛，多烯紫杉醇
Docetaxel多西他赛是一种taxol类似物，是一种microtubules解聚抑制剂，通过结合于稳定的微管发挥作用。
Docetaxel Chemical Structure
CAS: 114977-28-5
客户使用Selleck的Docetaxel发表文献192篇
产品质控
批次：
纯度：
99.98%
99.98
Docetaxel相关产品
相关信号通路图
Microtubule Associated抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| NUGC-3 | Growth Inhibition Assay | IC50=0.00308 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.00308 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=0.00307 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=0.00303 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=0.00302 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=0.00301 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=0.003 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=0.00298 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=0.00296 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=0.00295 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=0.00294 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=0.00293 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=0.00293 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.00286 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=0.00286 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=0.00285 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=0.00282 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=0.00282 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.00281 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.00281 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=0.0028 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=0.00278 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=0.00277 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=0.00277 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=0.00276 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=0.00274 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=0.00272 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=0.00271 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=0.00266 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=0.00265 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=0.00261 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.0026 μM | SANGER | ||
| OC-314 | Growth Inhibition Assay | IC50=0.00256 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=0.00254 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.00252 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=0.00251 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=0.0025 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=0.00247 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=0.00247 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=0.00246 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=0.00243 μM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50=0.00235 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.00235 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.00234 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.00233 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=0.00233 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=0.00232 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=0.00227 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.00226 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=0.00225 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.00225 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=0.00225 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=0.00222 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=0.0022 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=0.00217 μM | SANGER | ||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=0.00215 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=0.00212 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.00212 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=0.00209 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=0.00203 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.00199 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=0.00198 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.00197 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=0.00196 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.00194 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=0.00192 μM | SANGER | ||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.00192 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=0.00191 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.00189 μM | SANGER | ||
| NB17 | Growth Inhibition Assay | IC50=0.00189 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=0.00187 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.00184 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=0.00184 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=0.00183 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=0.00182 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=0.00181 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=0.00181 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=0.00181 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=0.0018 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=0.00178 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.00176 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=0.00176 μM | SANGER | ||
| U-2-OS | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=0.00174 μM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.00173 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=0.00173 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=0.00172 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.0017 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | ||
| D-336MG | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=0.00168 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=0.00163 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=0.00163 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=0.00161 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.00157 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=0.00156 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=0.00155 μM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50=0.00155 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.00154 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=0.00151 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=0.00148 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=0.00148 μM | SANGER | ||
| TI-73 | Growth Inhibition Assay | IC50=0.00144 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=0.00144 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.00144 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=0.00143 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.00141 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=0.00135 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=0.00135 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=0.00134 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=0.00132 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=0.00131 μM | SANGER | ||
| D-423MG | Growth Inhibition Assay | IC50=0.0013 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=0.00127 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=0.00127 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=0.00124 μM | SANGER | ||
| H9 | Growth Inhibition Assay | IC50=0.00124 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=0.00121 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=0.00121 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=0.00121 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=0.00119 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=0.00118 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=0.00118 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=0.00117 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=0.00117 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=0.00116 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.00113 μM | SANGER | ||
| KNS-62 | Growth Inhibition Assay | IC50=0.00112 μM | SANGER | ||
| EPLC-272H | Growth Inhibition Assay | IC50=0.00111 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.0011 μM | SANGER | ||
| NBsusSR | Growth Inhibition Assay | IC50=0.0011 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=0.00107 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=0.00106 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.00105 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=0.00105 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.00104 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=0.00104 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=0.00102 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=0.00102 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=0.00101 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=0.000989 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=0.000958 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=0.000947 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=0.000947 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=0.000941 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=0.000933 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=0.00091 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=0.000902 μM | SANGER | ||
| A549 | Growth Inhibition Assay | IC50=0.000882 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=0.000854 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=0.00084 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=0.000823 μM | SANGER | ||
| YH-13 | Growth Inhibition Assay | IC50=0.000791 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=0.000782 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=0.000778 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.000773 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=0.00077 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=0.000758 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=0.000758 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=0.000755 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.000745 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=0.000745 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=0.000739 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=0.00073 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=0.000728 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=0.000707 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=0.000706 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=0.0007 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.0007 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=0.000687 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=0.00068 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=0.000676 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=0.000674 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=0.000657 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=0.000647 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=0.000615 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=0.000592 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.000589 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=0.000587 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=0.000581 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=0.00058 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=0.000569 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=0.000561 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=0.000558 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=0.000544 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.000542 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=0.000528 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=0.000517 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=0.000501 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=0.000489 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=0.000479 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=0.000471 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=0.000466 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.000448 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=0.00043 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=0.000423 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=0.000416 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=0.000389 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=0.000388 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=0.000386 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.000375 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=0.000366 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=0.000339 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=0.000336 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.000302 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=0.000302 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.000281 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=0.000278 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=0.000268 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=0.00026 μM | SANGER | ||
| NB14 | Growth Inhibition Assay | IC50=0.00026 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=0.000255 μM | SANGER | ||
| HSC-4 | Growth Inhibition Assay | IC50=0.000239 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=0.000232 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=0.000185 μM | SANGER | ||
| D-566MG | Growth Inhibition Assay | IC50=0.000182 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=0.000179 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=0.000162 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=0.000159 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=0.000157 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=0.000143 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=0.000132 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=0.00312 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=0.00314 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=0.00315 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=0.00317 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=0.00322 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=0.00322 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.00324 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=0.00327 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=0.00328 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=0.00329 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=0.0033 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=0.00334 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=0.00335 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=0.00337 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=0.0034 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.00342 μM | SANGER | ||
| HuO9 | Growth Inhibition Assay | IC50=0.00346 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=0.00348 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=0.00355 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=0.00355 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=0.00358 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=0.00359 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=0.00362 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=0.00364 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=0.00368 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=0.00372 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=0.00376 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=0.00376 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=0.00376 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=0.00381 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=0.0039 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=0.00393 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.00396 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=0.00397 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.00399 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=0.004 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=0.00405 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.00407 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=0.00408 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=0.00408 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=0.0041 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=0.00412 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=0.00425 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=0.0043 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=0.00431 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=0.00433 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=0.00435 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=0.00437 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.00438 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=0.00438 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=0.00447 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=0.00451 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=0.00453 μM | SANGER | ||
| ECC10 | Growth Inhibition Assay | IC50=0.0046 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=0.00461 μM | SANGER | ||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.00469 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=0.00471 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=0.00482 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=0.00486 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.00497 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=0.00499 μM | SANGER | ||
| NCI-H1666 | Growth Inhibition Assay | IC50=0.00505 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=0.00505 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=0.00507 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=0.00508 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=0.0051 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=0.00511 μM | SANGER | ||
| KASUMI-1 | Growth Inhibition Assay | IC50=0.00511 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=0.00513 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=0.0053 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=0.00531 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.00531 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.00535 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=0.00535 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.0054 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.00545 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=0.0055 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=0.00551 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=0.00554 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=0.00559 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=0.00567 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=0.00568 μM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50=0.0057 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=0.00576 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.00586 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=0.00586 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=0.0059 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=0.006 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.00601 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=0.00607 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=0.00616 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=0.00622 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=0.00623 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=0.00627 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=0.00629 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=0.0063 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.00639 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=0.00641 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=0.00644 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.00652 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=0.00656 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.00658 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.00679 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=0.00679 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=0.00683 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=0.00689 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.00693 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=0.00696 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=0.007 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.00725 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=0.00725 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.00727 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=0.0073 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=0.0073 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.00732 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.00748 μM | SANGER | ||
| SW900 | Growth Inhibition Assay | IC50=0.00755 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=0.00758 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.00773 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=0.00781 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=0.00786 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=0.00788 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=0.00818 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=0.0082 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=0.00822 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=0.00827 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=0.0084 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.00857 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=0.00857 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=0.0086 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=0.0086 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.0088 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=0.00906 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.0091 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=0.00917 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=0.00926 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=0.00934 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=0.00977 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=0.0098 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.00983 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.00988 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=0.01005 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=0.01024 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.01029 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=0.01036 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=0.01047 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=0.01056 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.01056 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=0.01073 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=0.01077 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=0.01084 μM | SANGER | ||
| MOLT-13 | Growth Inhibition Assay | IC50=0.01086 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.01087 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=0.01093 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.01094 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=0.011 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=0.01102 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=0.01107 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=0.01126 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=0.01146 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=0.01148 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=0.01158 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=0.01166 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=0.01169 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=0.01173 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=0.01198 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=0.01198 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=0.012 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=0.01209 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=0.01229 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=0.01237 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=0.01242 μM | SANGER | ||
| NB7 | Growth Inhibition Assay | IC50=0.01243 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.01254 μM | SANGER | ||
| EW-22 | Growth Inhibition Assay | IC50=0.01256 μM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=0.01283 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=0.01283 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=0.013 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.01324 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=0.01328 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=0.0133 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=0.01354 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=0.0139 μM | SANGER | ||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.01406 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=0.01429 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=0.01438 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=0.01452 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=0.0146 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=0.0147 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=0.01477 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=0.01516 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=0.01523 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=0.01545 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=0.01549 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=0.016 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=0.01609 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.01636 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=0.01705 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=0.01737 μM | SANGER | ||
| NCI-H2291 | Growth Inhibition Assay | IC50=0.01838 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=0.01867 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=0.01887 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=0.01891 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=0.01934 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=0.01943 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=0.01956 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=0.02008 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=0.02036 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=0.02054 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=0.02068 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.02161 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=0.02172 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=0.02192 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=0.02196 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=0.02323 μM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.02349 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.02465 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=0.02474 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.02477 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=0.02502 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=0.02576 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=0.02654 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=0.027 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=0.0272 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=0.02819 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=0.02822 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=0.02837 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=0.02837 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=0.02904 μM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=0.02918 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=0.02998 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=0.0303 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=0.0303 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.03052 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=0.03063 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=0.03169 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=0.03185 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=0.03337 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=0.03421 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.03633 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=0.0371 μM | SANGER | ||
| RH-18 | Growth Inhibition Assay | IC50=0.03763 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=0.0379 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.03869 μM | SANGER | ||
| KP-N-YN | Growth Inhibition Assay | IC50=0.03876 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=0.03887 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=0.03904 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=0.03952 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=0.04007 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=0.04095 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=0.04305 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=0.04335 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.04417 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=0.04469 μM | SANGER | ||
| DMS-79 | Growth Inhibition Assay | IC50=0.04579 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.04614 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=0.04849 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=0.0501 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.05067 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=0.05093 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=0.05186 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=0.05384 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=0.05396 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.05446 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=0.05462 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.05788 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=0.058 μM | SANGER | ||
| SW948 | Growth Inhibition Assay | IC50=0.05996 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=0.06167 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=0.06244 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=0.06361 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=0.06374 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.06383 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=0.06582 μM | SANGER | ||
| BALL-1 | Growth Inhibition Assay | IC50=0.06674 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.07073 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=0.07369 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=0.07536 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=0.07676 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=0.07787 μM | SANGER | ||
| CW-2 | Growth Inhibition Assay | IC50=0.07832 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=0.08342 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=0.08501 μM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=0.08987 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=0.0901 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=0.09385 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=0.09556 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=0.09716 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=0.1004 μM | SANGER | ||
| T84 | Growth Inhibition Assay | IC50=0.10952 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=0.11641 μM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50=0.12324 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=0.13816 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=0.14937 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=0.1501 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=0.15843 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=0.16061 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=0.16278 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=0.17441 μM | SANGER | ||
| NCI-H2029 | Growth Inhibition Assay | IC50=0.20243 μM | SANGER | ||
| ZR-75-30 | Growth Inhibition Assay | IC50=0.20643 μM | SANGER | ||
| SW1116 | Growth Inhibition Assay | IC50=0.21117 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.27614 μM | SANGER | ||
| LU-135 | Growth Inhibition Assay | IC50=0.27739 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=0.28309 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=0.28773 μM | SANGER | ||
| NCI-H630 | Growth Inhibition Assay | IC50=0.29376 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=0.29883 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.31291 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=0.31784 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=0.3224 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.32298 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=0.33477 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=0.33755 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=0.33853 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=0.339 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=0.34309 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=0.37002 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=0.3793 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.38382 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=0.43976 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=0.49023 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=0.62172 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=0.65394 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=0.6622 μM | SANGER | ||
| H-EMC-SS | Growth Inhibition Assay | IC50=0.70546 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=0.72748 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=0.74112 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=0.77024 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=0.78781 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=0.79183 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.907 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=0.93352 μM | SANGER | ||
| NCI-H1993 | Growth Inhibition Assay | IC50=1.19289 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=1.22089 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Docetaxel多西他赛是一种taxol类似物，是一种microtubules解聚抑制剂，通过结合于稳定的微管发挥作用。 | |
|---|---|---|
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | Docetaxel是一种细胞毒性剂，尤其对于增殖细胞，Docetaxel促进微管蛋白束的形成，还能诱导持续的有丝分裂阻滞，随后分裂阻滞的细胞凋亡或永久抑制分裂。 Docetaxel抑制微管的动态不稳定性及踏车现象，导致染色体不能分开到子细胞中，这样又会反过来触发有丝分裂过早结束，而不是在细胞周期的特定时期进行抑制作用。[2] Docetaxel (150 ng/mL) 处理人类小细胞肺癌 N417细胞系 1小时，抑制50% 细胞生长。 Docetaxel 处理 KB 人类表皮癌细胞, T24 人类膀胱癌细胞, Calc18 人类乳腺癌细胞, 和HCT116人类结肠腺癌96-120小时，IC50值分别为8 ng/mL, 4 ng/mL, 5 ng/mL, 和 7 ng/mL。[3] Docetaxel 处理人类癌细胞Hs746T (胃), AGS (胃), HeLa (子宫颈), CaSki (子宫颈), BxPC3 (胰腺), Capan-1 (胰腺) 24小时，抑制克隆存活，IC50 分别为 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM, 0.3 nM。[4] 通过克隆形成实验测评Docetaxel处理人类 卵巢癌细胞系 OVCA432, A2780, A2780/cp8 12天期间，IC50值分别达到0.06 nM, 0.6 nM, 和3 nM。[5]Docetaxel 作用于9种培养的人类胃癌细胞系 (MKN-7, -28, -45, NUGC-4 和KATO-III, ST-SA-1, NAKAJIMA 和ST-KM, KKLS)时，IC50 分别为 >1.2 μM, 0.6 nM, 0.1 nM, 3.5 nM, 4 nM, 99 nM, 0.3 nM,0.5 nM, 0.9 nM。[6]在体外，Docetaxel在极低浓度时，抑制内皮细胞迁移，这并不影响微管的大体形态或抑制细胞增殖，对微管动力学产生更微妙的影响。Docetaxel 抑制 HUVEC 迁移，IC50 为1 pM。Docetaxel 抑制血管生成因子胸甘磷酸化酶或血管内皮生长因子刺激的HUVEC趋化性，IC 50 为10 pM 。[7] Docetaxel (30 μM) 在添加10％人血清的培养基中温育12小时，诱导人单核细胞。[8] | |||
|---|---|---|---|---|
| 细胞实验 | 细胞系 | 人类胃癌细胞系 MKN-28 | ||
| 浓度 | 6 nM | |||
| 孵育时间 | 3 天 | |||
| 方法 | 180 μL培养基中的2000个细胞接种到96孔板中，20 μL 药物溶液同时按一式三份加到每孔中。实验板在37°C下含5% CO2的培养箱中温育3天。在第3天,每孔加入25 μL MTT 试剂。温育4小时后，除去培养基。每孔加入0.2 mL DMSO，使用机械式搅拌机充分混合，溶解形成的MTT-甲臜晶体。在540 nm (OD)处测定吸光值。 | |||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | PIM1 cyclin B pSTAT3 / STAT3 p-p53 / p53 |
|
18426800 | |
| Immunofluorescence | α-tubulin cleaved PARP / cleaved caspase-3 Acetylated tubulin SQSTM1 / LAMP1 |
|
27177833 | |
| Growth inhibition assay | Cell viability |
|
22996738 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | Docetaxel (33 mg/kg/dose, 静脉注射，每四天注射3次) 处理M2OL2 结肠移植瘤，结果肿瘤生长延迟19.3。Docetaxel作用于MX-1, SK-MEL-2, LX-1 和 OVCAR-3 移植瘤，也具有很强的抗肿瘤活性。Docetaxel抑制成纤维细胞生长因子2的血管反应，IC50为5.4 mg/kg，Docetaxel按10 mg/kg剂量处理小鼠，在14天期间，每周注射两次，结果血管完全堵塞。Docetaxel对内皮细胞迁移和/或微血管形成具有选择性，因为炎症细胞浸润到基底膜对Docetaxel抑制不太敏感。[7] | |
|---|---|---|
| 动物实验 | Animal Models | 携带人类结肠癌移植瘤CX-1的小鼠 |
| Dosages | 33 mg/kg | |
| Administration | 静脉注射，每四天注射3次 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05156372 | Not yet recruiting | Prostate Cancer Metastatic|Castrate Resistant Prostate Cancer|Metastatic Prostate Cancer|Metastatic Prostate Adenocarcinoma |
The University of Texas Health Science Center at San Antonio |
December 2023 | Not Applicable |
| NCT05863325 | Recruiting | Locally Advanced or Metastatic Non-Small Cell Lung Cancer |
CSPC ZhongQi Pharmaceutical Technology Co. Ltd. |
June 27 2023 | Phase 2 |
| NCT05858398 | Not yet recruiting | Breast Cancer |
Centre Henri Becquerel|Erasmus Medical Center|Universitaire Ziekenhuizen KU Leuven |
May 30 2023 | Not Applicable |
化学信息&溶解度
| 分子量 | 807.88 | 分子式 | C43H53NO14 |
| CAS号 | 114977-28-5 | SDF | Download Docetaxel SDF |
| Smiles | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 100 mg/mL ( (123.78 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 100 mg/mL Water : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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